               SEQUENCE LISTING

<110> Cyprumed GmbH

<120> Improved pharmaceutical formulations of GLP-1 receptor agonists

<130> AD2996 PCT

<150> EP 20 19 4828.8
<151> 2020-09-07

<150> EP 20 20 8628.6
<151> 2020-11-19

<160> 1

<170> BiSSAP 1.3.6

<210> 1
<211> 33
<212> PRT
<213> ARTIFICIAL


<220> 
<221> SITE
<222> 1..1
<223> This residue is L-His, imidazopropionyl, alpha-hydroxy-His,
      D-His, deamino-His, 2-amino-His, beta-hydroxy-His, homo-His,
      N-alpha-acetyl-His, N-alpha-formyl-His, alpha-fluoromethyl-His,
      alpha-methyl-His, 3-pyridyl-Ala, 2-pyridyl-Ala, or 4-pyridyl-Ala

<220> 
<223> Based on human GLP-1

<220> 
<221> SITE
<222> 2..2
<223> This residue is Ala, Gly, Val, Leu, Ile, Thr, Ser, Lys,
      alpha-aminoisobutyric acid, (1-aminocyclopropyl)carboxylic acid,
      (1-aminocyclobutyl)carboxylic acid, (1-aminocyclopentyl)carboxylic
      acid, (1-aminocyclohexyl)carboxylic acidcarboxylic acid, or
      (1-aminocycloheptyl)carboxylic acid

<220> 
<221> SITE
<222> 6..6
<223> This residue is Lys or Phe

<220> 
<221> SITE
<222> 10..10
<223> This residue is Val or Leu

<220> 
<221> SITE
<222> 12..12
<223> This residue is Ser, Arg, Asn, Gln, or Glu

<220> 
<221> SITE
<222> 13..13
<223> This residue is Tyr or Gln

<220> 
<221> SITE
<222> 14..14
<223> This residue is Leu, Lys, or Met

<220> 
<221> SITE
<222> 16..16
<223> This residue is Gly, Glu, Lys, or alpha-aminoisobutyric acid

<220> 
<221> SITE
<222> 17..17
<223> This residue is Gln, Glu, or Arg

<220> 
<221> SITE
<222> 18..18
<223> This residue is Ala or Lys

<220> 
<221> SITE
<222> 19..19
<223> This residue is Ala or Val

<220> 
<221> SITE
<222> 20..20
<223> This residue is Val, His, Lys or Arg

<220> 
<221> SITE
<222> 24..24
<223> This residue is Ala, Glu, or Arg

<220> 
<221> SITE
<222> 25..25
<223> This residue is Trp or His

<220> 
<221> SITE
<222> 28..28
<223> This residue is Glu, Asn, Gly, Gln, or Arg

<220> 
<221> SITE
<222> 29..29
<223> This residue is Gly, alpha-aminoisobutyric acid, or absent

<220> 
<221> SITE
<222> 30..30
<223> This residue is Arg, Gly, Lys, or absent

<220> 
<221> SITE
<222> 31..31
<223> This residue is Gly, Ala, Glu, Pro, Lys, Arg, or absent

<220> 
<221> SITE
<222> 32..32
<223> This residue is Ser, Gly, Ala, Glu, Gln, Pro, Arg, or absent

<220> 
<221> SITE
<222> 33..33
<223> This residue is Gly or absent

<400> 1
Xaa Xaa Glu Gly Thr Xaa Thr Ser Asp Xaa Ser Xaa Xaa Xaa Glu Xaa 
1               5                   10                  15      
Xaa Xaa Xaa Xaa Lys Phe Ile Xaa Xaa Leu Val Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          
Xaa 
    

