                               SEQUENCE LISTING

<110> BROWN UNIVERSITY
      RHODE ISLAND HOSPITAL
 
<120> TARGETING ENHANCER RNAS FOR THE TREATMENT OF PRIMARY BRAIN TUMORS

<130> 405505-653001WO

<140> PCT/US2021/048671
<141> 2021-09-01

<150> 63/073,177
<151> 2020-09-01

<160> 194   

<170> PatentIn version 3.5

<210> 1
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
cgggagtaga agttgg                                                       16


<210> 2
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
gcgtctaggc tggcag                                                       16


<210> 3
<211> 668
<212> DNA
<213> Homo sapiens

<400> 3
atctagtaca tcatattgcc agcagggctc agcctgtgac cagcaaggtc tgggctccgt       60

ctggggccag ggtcaaggct cattccgtgg ccttgagcac agcctggtgt gtggctgggt      120

cgagtccagc agaagtctcg gggttttcca gcctccatcc gagtccggct ttgatgcctt      180

tcctggtcag acaggagccg ggccagtggc caagctgcca ggatggcttc cccggggccg      240

cggccgcctt ccttcccctc ctgcccgggc tggctctggt cgccactagg ggttgaagat      300

gagggctctc ctgggaagct cttggctgag gatccgcctg gtcccggagc cgtgaaaaca      360

acagctgggc ctggtggggg tggggaggct gagcggagag gccagctccc ttggctgctg      420

ggcagggtct tctgtccaca gctgcctcag gcggctgttt ccaaaggtgt ttccagcttc      480

ccaggcccac cctgaggccc cgcaccgcca gggaggtgga aggcacggag cagcgaagcc      540

cggccccggc cccggccgcc cgaccagctc acagaggaac acctgtgggg gggcctgtgg      600

gcggttcaca gagggatgta ggaacgtgcc tgtgggaggc cgtagccccg gagagcagag      660

gcctggcc                                                               668


<210> 4
<211> 291
<212> DNA
<213> Homo sapiens

<400> 4
cggcagcaac actgccacgc gaatccgcgc cggccaatca gcatggccag gggcggggct       60

tccctgaggc gcgccgagag gcggtggccc acttccggca ataatcgcct ggtcgccgtc      120

aggtgccggc ccaggtggca ggcgcgcccg ttgggcactg ggggacgcgg gcgcgtcagg      180

tgaagactgg gggctgcagg cgcgctaggt aggtacgggg tgccgcgggc gcgtcaggtg      240

aagactgggc gccgcaggcg ccttaggtga agattgggga tcgcgggcgc g               291


<210> 5
<211> 1832
<212> DNA
<213> Homo sapiens

<400> 5
agaattgcct gaaccagggg ttggaggttg cagcgggtgg aaattttgcc actgcactcc       60

agcctgggtg acagagtgag accctgtctc aaagaaaaaa aaaaaaagat acatcatctg      120

ggacaataac cttgaaaagc aggggtccca gacgacctta tttgcagaga atgcgactgc      180

agacggcaag caggggggca tgcccttcgc tctctgtcct ctgctctttg ccccggccac      240

tgtcggcctc atctgaaggc cacctgtgcc tcacggtctg aaaacgctgg tttccacagc      300

tgcttctcct tccaaatttc cctggagtct tgctttggtg gcgaacctct ggttctattc      360

cttcctttta actgaagcct ataggaaaaa tttggaagtt gaaatatgcc agtccaagga      420

aggtggacgt ggagttctga gggtgggggt gctgccaggg aagtggcact gtgcagggga      480

ccgcccctgg gaccccctgg ttcctgtcaa gagcaggtag gggctgggcg cggtggctca      540

cgcctataat cccagcactt tgggaggtca aggagagtgg atcacctaag gtcaggagtt      600

caagaccagc tgaccaacat ggtgaaaccc cgtctctact aaaaatacaa aaattagctg      660

ggcgtggtgg caggcgccta taatcccagg tattcaggag gctgaggcag gagaatagct      720

tgaacccagg aggcagaggt tgcagtgagc tgagatcgca ccactgcact ccagcctggg      780

cgacagagcg agactctgtc tacacacaca cacacacaca cacagacaca cacacacaca      840

cagatcaggt aggatgtgag gtgtgtcctc atggccggac atggggtggg tggggccaaa      900

caaccacagg gactcgtcct gtggccactg ctgctcagga agtggatccc aaggagcaga      960

gtcgccagac ccctcagttc ccagctccac atttaaggca ggtctggcca tgagccaggc     1020

ctctgcatgt gacctggggc ctcactgtgg catggctgcc tgtcccacct gtggatgttg     1080

cctgtgctgt gtagaagcca catagcctcc ggggcggctc cccagaatgc cacatttcct     1140

gtctctggct ctgatggcgt ctaggctggc aggggtcccg gccccagcag tactgttgcc     1200

gggcagagct cagggccacg tgcagttggg tctggctgag agcatctcat gggtttatga     1260

gaacccttcc agcacaaagg ggcatttatc aggcagggat ggcatgtctt ggtctgaaca     1320

caggaaacac agaaatagcc tttcacagag tgccagcagg gctgggctcg cctgctgtgg     1380

agggtgtcgg ctttccaact ccttctccaa gctgtgcgac ccgtccatgt tcccctgtga     1440

gttgttctgt cccagacagg gcattccctg agaacgctcc tgctgcaact ggagggagag     1500

aggcagggag gggaaagggg aagacttgca gggagaagga agaagggaga cagatggaga     1560

cagacagaag gagggatgga agaaatgaga gagagagagg gagggagatg gaaacataga     1620

ttgtctccac tgtgacaccc tgcctccatg gttctccatg atgggaatgg aattcatgtc     1680

tcacctggca gcaagggtct ccacaatatg acttcacctt ctttctctta gtaaggcgag     1740

agcagacagg cagacactcc aggaagtaac tgatgtgtcc ctgaaaatgc ctgtctttcc     1800

cagcttgtac aactttgctt gtgttatttc tt                                   1832


<210> 6
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 6
uguacaagcu gggaaagaca                                                   20


<210> 7
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ugucuuuccc agcuuguaca                                                   20


<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 8
tgtctttccc agcttgtaca                                                   20


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 9
tgtctttccc agcttgtaca                                                   20


<210> 10
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 10
cugggaaaga caggcauuuu                                                   20


<210> 11
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
aaaaugccug ucuuucccag                                                   20


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 12
aaaatgcctg tctttcccag                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 13
aaaatgcctg tctttcccag                                                   20


<210> 14
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 14
caggcauuuu cagggacaca                                                   20


<210> 15
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
ugugucccug aaaaugccug                                                   20


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 16
tgtgtccctg aaaatgcctg                                                   20


<210> 17

<400> 17
000


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 18
tgtgtccctg aaaatgcctg                                                   20


<210> 19
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 19
ucagggacac aucaguuacu                                                   20


<210> 20
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
aguaacugau gugucccuga                                                   20


<210> 21
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 21
agtaactgat gtgtccctga                                                   20


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 22
agtaactgat gtgtccctga                                                   20


<210> 23
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 23
agggacacau caguuacuuc                                                   20


<210> 24
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
gaaguaacug augugucccu                                                   20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 25
gaagtaactg atgtgtccct                                                   20


<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 26
gaagtaactg atgtgtccct                                                   20


<210> 27
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 27
aaagaaggug aagucauauu                                                   20


<210> 28
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
aauaugacuu caccuucuuu                                                   20


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 29
aatatgactt caccttcttt                                                   20


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 30
aatatgactt caccttcttt                                                   20


<210> 31
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 31
gaagucauau uguggagacc                                                   20


<210> 32
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ggucuccaca auaugacuuc                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 33
ggtctccaca atatgacttc                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 34
ggtctccaca atatgacttc                                                   20


<210> 35
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 35
gcugccaggu gagacaugaa                                                   20


<210> 36
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
uucaugucuc accuggcagc                                                   20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 37
ttcatgtctc acctggcagc                                                   20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 38
ttcatgtctc acctggcagc                                                   20


<210> 39
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 39
ugagacauga auuccauucc                                                   20


<210> 40
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
ggaauggaau ucaugucuca                                                   20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 41
ggaatggaat tcatgtctca                                                   20


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 42
ggaatggaat tcatgtctca                                                   20


<210> 43
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 43
ugucacagug gagacaaucu                                                   20


<210> 44
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
agauugucuc cacugugaca                                                   20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 45
agattgtctc cactgtgaca                                                   20


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 46
agattgtctc cactgtgaca                                                   20


<210> 47
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 47
ucuuccaucc cuccuucugu                                                   20


<210> 48
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
acagaaggag ggauggaaga                                                   20


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 49
acagaaggag ggatggaaga                                                   20


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 50
acagaaggag ggatggaaga                                                   20


<210> 51
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 51
ucugggacag aacaacucac                                                   20


<210> 52
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
gugaguuguu cugucccaga                                                   20


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 53
gtgagttgtt ctgtcccaga                                                   20


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 54
gtgagttgtt ctgtcccaga                                                   20


<210> 55
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 55
cugugaaagg cuauuucugu                                                   20


<210> 56
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
acagaaauag ccuuucacag                                                   20


<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 57
acagaaatag cctttcacag                                                   20


<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 58
acagaaatag cctttcacag                                                   20


<210> 59
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 59
aaggcuauuu cuguguuucc                                                   20


<210> 60
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
ggaaacacag aaauagccuu                                                   20


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 61
ggaaacacag aaatagcctt                                                   20


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 62
ggaaacacag aaatagcctt                                                   20


<210> 63
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 63
uucuguguuu ccuguguuca                                                   20


<210> 64
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
ugaacacagg aaacacagaa                                                   20


<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 65
tgaacacagg aaacacagaa                                                   20


<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 66
tgaacacagg aaacacagaa                                                   20


<210> 67
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 67
ucuguguuuc cuguguucag                                                   20


<210> 68
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
cugaacacag gaaacacaga                                                   20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 69
ctgaacacag gaaacacaga                                                   20


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 70
ctgaacacag gaaacacaga                                                   20


<210> 71
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 71
cagaccaaga caugccaucc                                                   20


<210> 72
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
ggauggcaug ucuuggucug                                                   20


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 73
ggatggcatg tcttggtctg                                                   20


<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 74
ggatggcatg tcttggtctg                                                   20


<210> 75
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 75
caugccaucc cugccugaua                                                   20


<210> 76
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 76
uaucaggcag ggauggcaug                                                   20


<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 77
tatcaggcag ggatggcatg                                                   20


<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 78
tatcaggcag ggatggcatg                                                   20


<210> 79
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 79
ccugccugau aaaugccccu                                                   20


<210> 80
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
aggggcauuu aucaggcagg                                                   20


<210> 81
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 81
aggggcattt atcaggcagg                                                   20


<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 82
aggggcattt atcaggcagg                                                   20


<210> 83
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 83
uuugugcugg aaggguucuc                                                   20


<210> 84
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
gagaacccuu ccagcacaaa                                                   20


<210> 85
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 85
gagaaccctt ccagcacaaa                                                   20


<210> 86
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 86
gagaaccctt ccagcacaaa                                                   20


<210> 87
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 87
uugugcugga aggguucuca                                                   20


<210> 88
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 88
ugagaacccu uccagcacaa                                                   20


<210> 89
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 89
tgagaaccct tccagcacaa                                                   20


<210> 90
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 90
tgagaaccct tccagcacaa                                                   20


<210> 91
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 91
guucucauaa acccaugaga                                                   20


<210> 92
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 92
ucucaugggu uuaugagaac                                                   20


<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 93
tctcatgggt ttatgagaac                                                   20


<210> 94
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 94
tctcatgggt ttatgagaac                                                   20


<210> 95
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 95
ucucauaaac ccaugagaug                                                   20


<210> 96
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 96
caucucaugg guuuaugaga                                                   20


<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 97
catctcatgg gtttatgaga                                                   20


<210> 98
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 98
catctcatgg gtttatgaga                                                   20


<210> 99
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 99
ccucacaucc uaccugaucu                                                   20


<210> 100
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 100
agaucaggua ggaugugagg                                                   20


<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 101
agatcaggta ggatgtgagg                                                   20


<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 102
agatcaggta ggatgtgagg                                                   20


<210> 103
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 103
uguguagaca gagucucgcu                                                   20


<210> 104
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 104
agcgagacuc ugucuacaca                                                   20


<210> 105
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 105
agcgagactc tgtctacaca                                                   20


<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 106
agcgagactc tgtctacaca                                                   20


<210> 107
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 107
uucaccaugu uggucagcug                                                   20


<210> 108
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 108
cagcugacca acauggugaa                                                   20


<210> 109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 109
cagctgacca acatggtgaa                                                   20


<210> 110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 110
cagctgacca acatggtgaa                                                   20


<210> 111
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 111
uuggucagcu ggucuugaac                                                   20


<210> 112
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 112
guucaagacc agcugaccaa                                                   20


<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 113
gttcaagacc agctgaccaa                                                   20


<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 114
gttcaagacc agctgaccaa                                                   20


<210> 115
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 115
cuuggacugg cauauuucaa                                                   20


<210> 116
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 116
uugaaauaug ccaguccaag                                                   20


<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 117
ttgaaatatg ccagtccaag                                                   20


<210> 118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 118
ttgaaatatg ccagtccaag                                                   20


<210> 119
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 119
cuggcauauu ucaacuucca                                                   20


<210> 120
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 120
uggaaguuga aauaugccag                                                   20


<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 121
tggaagttga aatatgccag                                                   20


<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 122
tggaagttga aatatgccag                                                   20


<210> 123
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 123
uggcauauuu caacuuccaa                                                   20


<210> 124
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 124
uuggaaguug aaauaugcca                                                   20


<210> 125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 125
ttggaagttg aaatatgcca                                                   20


<210> 126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 126
ttggaagttg aaatatgcca                                                   20


<210> 127
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 127
uauuucaacu uccaaauuuu                                                   20


<210> 128
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 128
aaaauuugga aguugaaaua                                                   20


<210> 129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 129
aaaatttgga agttgaaata                                                   20


<210> 130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 130
aaaatttgga agttgaaata                                                   20


<210> 131
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 131
uuuccuauag gcuucaguua                                                   20


<210> 132
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 132
uaacugaagc cuauaggaaa                                                   20


<210> 133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 133
taactgaagc ctataggaaa                                                   20


<210> 134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 134
taactgaagc ctataggaaa                                                   20


<210> 135
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 135
uccuauaggc uucaguuaaa                                                   20


<210> 136
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 136
uuuaacugaa gccuauagga                                                   20


<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 137
tttaactgaa gcctatagga                                                   20


<210> 138
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 138
tttaactgaa gcctatagga                                                   20


<210> 139
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 139
aguuaaaagg aaggaauaga                                                   20


<210> 140
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 140
ucuauuccuu ccuuuuaacu                                                   20


<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 141
tctattcctt ccttttaact                                                   20


<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 142
tctattcctt ccttttaact                                                   20


<210> 143
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 143
uucgccacca aagcaagacu                                                   20


<210> 144
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 144
agucuugcuu ugguggcgaa                                                   20


<210> 145
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 145
agtcttgctt tggtggcgaa                                                   20


<210> 146
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 146
agtcttgctt tggtggcgaa                                                   20


<210> 147
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 147
agcuguggaa accagcguuu                                                   20


<210> 148
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 148
aaacgcuggu uuccacagcu                                                   20


<210> 149
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 149
aaacgctggt ttccacagct                                                   20


<210> 150
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 150
aaacgctggt ttccacagct                                                   20


<210> 151
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 151
cucugcaaau aaggucgucu                                                   20


<210> 152
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 152
agacgaccuu auuugcagag                                                   20


<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 153
agacgacctt atttgcagag                                                   20


<210> 154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 154
agacgacctt atttgcagag                                                   20


<210> 155
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 155
ugggaccccu gcuuuucaag                                                   20


<210> 156
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 156
cuugaaaagc agggguccca                                                   20


<210> 157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 157
cttgaaaagc aggggtccca                                                   20


<210> 158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 158
cttgaaaagc aggggtccca                                                   20


<210> 159
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 159
uuuucaaggu uauuguccca                                                   20


<210> 160
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 160
ugggacaaua accuugaaaa                                                   20


<210> 161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 161
tgggacaata accttgaaaa                                                   20


<210> 162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 162
tgggacaata accttgaaaa                                                   20


<210> 163
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 163
auugucccag augauguauc                                                   20


<210> 164
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 164
gauacaucau cugggacaau                                                   20


<210> 165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 165
gatacatcat ctgggacaat                                                   20


<210> 166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 166
gatacatcat ctgggacaat                                                   20


<210> 167
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 167
uugucccaga ugauguaucu                                                   20


<210> 168
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 168
agauacauca ucugggacaa                                                   20


<210> 169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 169
agatacatca tctgggacaa                                                   20


<210> 170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 170
agatacatca tctgggacaa                                                   20


<210> 171
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 171
ugucccagau gauguaucuu                                                   20


<210> 172
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 172
aagauacauc aucugggaca                                                   20


<210> 173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 173
aagatacatc atctgggaca                                                   20


<210> 174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 174
aagatacatc atctgggaca                                                   20


<210> 175
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 175
gucccagaug auguaucuuu                                                   20


<210> 176
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 176
aaagauacau caucugggac                                                   20


<210> 177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 177
aaagatacat catctgggac                                                   20


<210> 178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 178
aaagatacat catctgggac                                                   20


<210> 179
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 179
ucccagauga uguaucuuuu                                                   20


<210> 180
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 180
aaaagauaca ucaucuggga                                                   20


<210> 181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 181
aaaagataca tcatctggga                                                   20


<210> 182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 182
aaaagataca tcatctggga                                                   20


<210> 183
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 183
agugcagugg caaaauuucc                                                   20


<210> 184
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 184
ggaaauuuug ccacugcacu                                                   20


<210> 185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 185
ggaaattttg ccactgcact                                                   20


<210> 186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 186
ggaaattttg ccactgcact                                                   20


<210> 187
<211> 20
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      target sequence

<400> 187
ggcaaaauuu ccacccgcug                                                   20


<210> 188
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 188
cagcgggugg aaauuuugcc                                                   20


<210> 189
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 189
cagcgggtgg aaattttgcc                                                   20


<210> 190
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 190
cagcgggtgg aaattttgcc                                                   20


<210> 191
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 191
gggtcagctg ccaatgctag                                                   20


<210> 192
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 192
gggtcagctg ccaatgctag                                                   20


<210> 193
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> Locked nucleic acid

<220>
<221> modified_base
<222> (16)..(20)
<223> Locked nucleic acid

<400> 193
taatcgtatt tgtcaatcat                                                   20


<210> 194
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(5)
<223> 2'MOE nucleotide

<220>
<221> modified_base
<222> (16)..(20)
<223> 2'MOE nucleotide

<400> 194
taatcgtatt tgtcaatcat                                                   20


