                         SEQUENCE LISTING

<110>  The Trustees of Columbia University in the City of New York
 
<120>  GENETIC MODIFICATIONS FOR XENOTRANSPLANTATION

<130>  14648-015-228

<140>  
<141>  

<150>  US 63/108,986
<151>  2020-11-03

<150>  US 63/075,285
<151>  2020-09-07

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  323
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human leukocyte surface antigen CD47 isoform 1 precursor 

<300>
<308>  NP_001768.1
<309>  2020-08-30
<313>  (1)..(323)

<400>  1

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  2
<211>  305
<212>  PRT
<213>  Homo sapiens

<220>
<223>  human CD47 protein

<300>
<308>  NP_942088
<309>  2020-08-31
<313>  (1)..(305)

<400>  2

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 


<210>  3
<211>  5292
<212>  DNA
<213>  Homo sapiens 

<220>
<223>  human CD47 transcript variant 1 (mRNA)

<300>
<308>  NM_001777
<309>  2020-08-30
<313>  (1)..(5292)

<400>  3
gcagcctggg cagtgggtcc tgcctgtgac gcgcggcggc ggtcggtcct gcctgtaacg       60

gcggcggcgg ctgctgctcc ggacacctgc ggcggcggcg gcgaccccgc ggcgggcgcg      120

gagatgtggc ccctggtagc ggcgctgttg ctgggctcgg cgtgctgcgg atcagctcag      180

ctactattta ataaaacaaa atctgtagaa ttcacgtttt gtaatgacac tgtcgtcatt      240

ccatgctttg ttactaatat ggaggcacaa aacactactg aagtatacgt aaagtggaaa      300

tttaaaggaa gagatattta cacctttgat ggagctctaa acaagtccac tgtccccact      360

gactttagta gtgcaaaaat tgaagtctca caattactaa aaggagatgc ctctttgaag      420

atggataaga gtgatgctgt ctcacacaca ggaaactaca cttgtgaagt aacagaatta      480

accagagaag gtgaaacgat catcgagcta aaatatcgtg ttgtttcatg gttttctcca      540

aatgaaaata ttcttattgt tattttccca atttttgcta tactcctgtt ctggggacag      600

tttggtatta aaacacttaa atatagatcc ggtggtatgg atgagaaaac aattgcttta      660

cttgttgctg gactagtgat cactgtcatt gtcattgttg gagccattct tttcgtccca      720

ggtgaatatt cattaaagaa tgctactggc cttggtttaa ttgtgacttc tacagggata      780

ttaatattac ttcactacta tgtgtttagt acagcgattg gattaacctc cttcgtcatt      840

gccatattgg ttattcaggt gatagcctat atcctcgctg tggttggact gagtctctgt      900

attgcggcgt gtataccaat gcatggccct cttctgattt caggtttgag tatcttagct      960

ctagcacaat tacttggact agtttatatg aaatttgtgg cttccaatca gaagactata     1020

caacctccta ggaaagctgt agaggaaccc cttaatgcat tcaaagaatc aaaaggaatg     1080

atgaatgatg aataactgaa gtgaagtgat ggactccgat ttggagagta gtaagacgtg     1140

aaaggaatac acttgtgttt aagcaccatg gccttgatga ttcactgttg gggagaagaa     1200

acaagaaaag taactggttg tcacctatga gacccttacg tgattgttag ttaagttttt     1260

attcaaagca gctgtaattt agttaataaa ataattatga tctatgttgt ttgcccaatt     1320

gagatccagt tttttgttgt tatttttaat caattagggg caatagtaga atggacaatt     1380

tccaagaatg atgcctttca ggtcctaggg cctctggcct ctaggtaacc agtttaaatt     1440

ggttcagggt gataactact tagcactgcc ctggtgatta cccagagata tctatgaaaa     1500

ccagtggctt ccatcaaacc tttgccaact caggttcaca gcagctttgg gcagttatgg     1560

cagtatggca ttagctgaga ggtgtctgcc acttctgggt caatggaata ataaattaag     1620

tacaggcagg aatttggttg ggagcatctt gtatgatctc cgtatgatgt gatattgatg     1680

gagatagtgg tcctcattct tgggggttgc cattcccaca ttcccccttc aacaaacagt     1740

gtaacaggtc cttcccagat ttagggtact tttattgatg gatatgtttt ccttttattc     1800

acataacccc ttgaaaccct gtcttgtcct cctgttactt gcttctgctg tacaagatgt     1860

agcacctttt ctcctctttg aacatggtct agtgacacgg tagcaccagt tgcaggaagg     1920

agccagactt gttctcagag cactgtgttc acacttttca gcaaaaatag ctatggttgt     1980

aacatatgta ttcccttcct ctgatttgaa ggcaaaaatc tacagtgttt cttcacttct     2040

tttctgatct ggggcatgaa aaaagcaaga ttgaaatttg aactatgagt ctcctgcatg     2100

gcaacaaaat gtgtgtcacc atcaggccaa caggccagcc cttgaatggg gatttattac     2160

tgttgtatct atgttgcatg ataaacattc atcaccttcc tcctgtagtc ctgcctcgta     2220

ctccccttcc cctatgattg aaaagtaaac aaaacccaca tttcctatcc tggttagaag     2280

aaaattaatg ttctgacagt tgtgatcgcc tggagtactt ttagactttt agcattcgtt     2340

ttttacctgt ttgtggatgt gtgtttgtat gtgcatacgt atgagatagg cacatgcatc     2400

ttctgtatgg acaaaggtgg ggtacctaca ggagagcaaa ggttaatttt gtgcttttag     2460

taaaaacatt taaatacaaa gttctttatt gggtggaatt atatttgatg caaatatttg     2520

atcacttaaa acttttaaaa cttctaggta atttgccacg ctttttgact gctcaccaat     2580

accctgtaaa aatacgtaat tcttcctgtt tgtgtaataa gatattcata tttgtagttg     2640

cattaataat agttatttct tagtccatca gatgttcccg tgtgcctctt ttatgccaaa     2700

ttgattgtca tatttcatgt tgggaccaag tagtttgccc atggcaaacc taaatttatg     2760

acctgctgag gcctctcaga aaactgagca tactagcaag acagctcttc ttgaaaaaaa     2820

aaatatgtat acacaaatat atacgtatat ctatatatac gtatgtatat acacacatgt     2880

atattcttcc ttgattgtgt agctgtccaa aataataaca tatatagagg gagctgtatt     2940

cctttataca aatctgatgg ctcctgcagc actttttcct tctgaaaata tttacatttt     3000

gctaacctag tttgttactt taaaaatcag ttttgatgaa aggagggaaa agcagatgga     3060

cttgaaaaag atccaagctc ctattagaaa aggtatgaaa atctttatag taaaattttt     3120

tataaactaa agttgtacct tttaatatgt agtaaactct catttatttg gggttcgctc     3180

ttggatctca tccatccatt gtgttctctt taatgctgcc tgccttttga ggcattcact     3240

gccctagaca atgccaccag agatagtggg ggaaatgcca gatgaaacca actcttgctc     3300

tcactagttg tcagcttctc tggataagtg accacagaag caggagtcct cctgcttggg     3360

catcattggg ccagttcctt ctctttaaat cagatttgta atggctccca aattccatca     3420

catcacattt aaattgcaga cagtgttttg cacatcatgt atctgttttg tcccataata     3480

tgctttttac tccctgatcc cagtttctgc tgttgactct tccattcagt tttatttatt     3540

gtgtgttctc acagtgacac catttgtcct tttctgcaac aacctttcca gctacttttg     3600

ccaaattcta tttgtcttct ccttcaaaac attctccttt gcagttcctc ttcatctgtg     3660

tagctgctct tttgtctctt aacttaccat tcctatagta ctttatgcat ctctgcttag     3720

ttctattagt tttttggcct tgctcttctc cttgatttta aaattccttc tatagctaga     3780

gcttttcttt ctttcattct ctcttcctgc agtgttttgc atacatcaga agctaggtac     3840

ataagttaaa tgattgagag ttggctgtat ttagatttat cactttttaa tagggtgagc     3900

ttgagagttt tctttctttc tgtttttttt ttttgttttt tttttttttt tttttttttt     3960

tttttttgac taatttcaca tgctctaaaa accttcaaag gtgattattt ttctcctgga     4020

aactccaggt ccattctgtt taaatcccta agaatgtcag aattaaaata acagggctat     4080

cccgtaattg gaaatatttc ttttttcagg atgctatagt caatttagta agtgaccacc     4140

aaattgttat ttgcactaac aaagctcaaa acacgataag tttactcctc catctcagta     4200

ataaaaatta agctgtaatc aaccttctag gtttctcttg tcttaaaatg ggtattcaaa     4260

aatggggatc tgtggtgtat gtatggaaac acatactcct taatttacct gttgttggaa     4320

actggagaaa tgattgtcgg gcaaccgttt attttttatt gtattttatt tggttgaggg     4380

atttttttat aaacagtttt acttgtgtca tattttaaaa ttactaactg ccatcacctg     4440

ctggggtcct ttgttaggtc attttcagtg actaataggg ataatccagg taactttgaa     4500

gagatgagca gtgagtgacc aggcagtttt tctgccttta gctttgacag ttcttaatta     4560

agatcattga agaccagctt tctcataaat ttctcttttt gaaaaaaaga aagcatttgt     4620

actaagctcc tctgtaagac aacatcttaa atcttaaaag tgttgttatc atgactggtg     4680

agagaagaaa acattttgtt tttattaaat ggagcattat ttacaaaaag ccattgttga     4740

gaattagatc ccacatcgta taaatatcta ttaaccattc taaataaaga gaactccagt     4800

gttgctatgt gcaagatcct ctcttggagc ttttttgcat agcaattaaa ggtgtgctat     4860

ttgtcagtag ccattttttt gcagtgattt gaagaccaaa gttgttttac agctgtgtta     4920

ccgttaaagg tttttttttt tatatgtatt aaatcaattt atcactgttt aaagctttga     4980

atatctgcaa tctttgccaa ggtacttttt tatttaaaaa aaaacataac tttgtaaata     5040

ttaccctgta atattatata tacttaataa aacattttaa gctattttgt tgggctattt     5100

ctattgctgc tacagcagac cacaagcaca tttctgaaaa atttaattta ttaatgtatt     5160

tttaagttgc ttatattcta ggtaacaatg taaagaatga tttaaaatat taattatgaa     5220

ttttttgagt ataataccca ataagctttt aattagagca gagttttaat taaaagtttt     5280

aaatcagtcc aa                                                         5292


<210>  4
<211>  5288
<212>  DNA
<213>  Homo sapiens

<220>
<223>  human CD47 transcript variant 2 (mRNA)

<300>
<308>  NM_198793.3 
<309>  2020-08-31
<313>  (1)..(5234)

<400>  4
ggggagcagg cgggggagcg ggcgggaagc agtgggagcg cgcgtgcgcg cggccgtgca       60

gcctgggcag tgggtcctgc ctgtgacgcg cggcggcggt cggtcctgcc tgtaacggcg      120

gcggcggctg ctgctccaga cacctgcggc ggcggcggcg accccgcggc gggcgcggag      180

atgtggcccc tggtagcggc gctgttgctg ggctcggcgt gctgcggatc agctcagcta      240

ctatttaata aaacaaaatc tgtagaattc acgttttgta atgacactgt cgtcattcca      300

tgctttgtta ctaatatgga ggcacaaaac actactgaag tatacgtaaa gtggaaattt      360

aaaggaagag atatttacac ctttgatgga gctctaaaca agtccactgt ccccactgac      420

tttagtagtg caaaaattga agtctcacaa ttactaaaag gagatgcctc tttgaagatg      480

gataagagtg atgctgtctc acacacagga aactacactt gtgaagtaac agaattaacc      540

agagaaggtg aaacgatcat cgagctaaaa tatcgtgttg tttcatggtt ttctccaaat      600

gaaaatattc ttattgttat tttcccaatt tttgctatac tcctgttctg gggacagttt      660

ggtattaaaa cacttaaata tagatccggt ggtatggatg agaaaacaat tgctttactt      720

gttgctggac tagtgatcac tgtcattgtc attgttggag ccattctttt cgtcccaggt      780

gaatattcat taaagaatgc tactggcctt ggtttaattg tgacttctac agggatatta      840

atattacttc actactatgt gtttagtaca gcgattggat taacctcctt cgtcattgcc      900

atattggtta ttcaggtgat agcctatatc ctcgctgtgg ttggactgag tctctgtatt      960

gcggcgtgta taccaatgca tggccctctt ctgatttcag gtttgagtat cttagctcta     1020

gcacaattac ttggactagt ttatatgaaa tttgtggctt ccaatcagaa gactatacaa     1080

cctcctagga ataactgaag tgaagtgatg gactccgatt tggagagtag taagacgtga     1140

aaggaataca cttgtgttta agcaccatgg ccttgatgat tcactgttgg ggagaagaaa     1200

caagaaaagt aactggttgt cacctatgag acccttacgt gattgttagt taagttttta     1260

ttcaaagcag ctgtaattta gttaataaaa taattatgat ctatgttgtt tgcccaattg     1320

agatccagtt ttttgttgtt atttttaatc aattaggggc aatagtagaa tggacaattt     1380

ccaagaatga tgcctttcag gtcctagggc ctctggcctc taggtaacca gtttaaattg     1440

gttcagggtg ataactactt agcactgccc tggtgattac ccagagatat ctatgaaaac     1500

cagtggcttc catcaaacct ttgccaactc aggttcacag cagctttggg cagttatggc     1560

agtatggcat tagctgagag gtgtctgcca cttctgggtc aatggaataa taaattaagt     1620

acaggcagga atttggttgg gagcatcttg tatgatctcc gtatgatgtg atattgatgg     1680

agatagtggt cctcattctt gggggttgcc attcccacat tcccccttca acaaacagtg     1740

taacaggtcc ttcccagatt tagggtactt ttattgatgg atatgttttc cttttattca     1800

cataacccct tgaaaccctg tcttgtcctc ctgttacttg cttctgctgt acaagatgta     1860

gcaccttttc tcctctttga acatggtcta gtgacacggt agcaccagtt gcaggaagga     1920

gccagacttg ttctcagagc actgtgttca cacttttcag caaaaatagc tatggttgta     1980

acatatgtat tcccttcctc tgatttgaag gcaaaaatct acagtgtttc ttcacttctt     2040

ttctgatctg gggcatgaaa aaagcaagat tgaaatttga actatgagtc tcctgcatgg     2100

caacaaaatg tgtgtcacca tcaggccaac aggccagccc ttgaatgggg atttattact     2160

gttgtatcta tgttgcatga taaacattca tcaccttcct cctgtagtcc tgcctcgtac     2220

tccccttccc ctatgattga aaagtaaaca aaacccacat ttcctatcct ggttagaaga     2280

aaattaatgt tctgacagtt gtgatcgcct ggagtacttt tagactttta gcattcgttt     2340

tttacctgtt tgtggatgtg tgtttgtatg tgcatacgta tgagataggc acatgcatct     2400

tctgtatgga caaaggtggg gtacctacag gagagcaaag gttaattttg tgcttttagt     2460

aaaaacattt aaatacaaag ttctttattg ggtggaatta tatttgatgc aaatatttga     2520

tcacttaaaa cttttaaaac ttctaggtaa tttgccacgc tttttgactg ctcaccaata     2580

ccctgtaaaa atacgtaatt cttcctgttt gtgtaataag atattcatat ttgtagttgc     2640

attaataata gttatttctt agtccatcag atgttcccgt gtgcctcttt tatgccaaat     2700

tgattgtcat atttcatgtt gggaccaagt agtttgccca tggcaaacct aaatttatga     2760

cctgctgagg cctctcagaa aactgagcat actagcaaga cagctcttct tgaaaaaaaa     2820

aatatgtata cacaaatata tacgtatatc tatatatacg tatgtatata cacacatgta     2880

tattcttcct tgattgtgta gctgtccaaa ataataacat atatagaggg agctgtattc     2940

ctttatacaa atctgatggc tcctgcagca ctttttcctt ctgaaaatat ttacattttg     3000

ctaacctagt ttgttacttt aaaaatcagt tttgatgaaa ggagggaaaa gcagatggac     3060

ttgaaaaaga tccaagctcc tattagaaaa ggtatgaaaa tctttatagt aaaatttttt     3120

ataaactaaa gttgtacctt ttaatatgta gtaaactctc atttatttgg ggttcgctct     3180

tggatctcat ccatccattg tgttctcttt aatgctgcct gccttttgag gcattcactg     3240

ccctagacaa tgccaccaga gatagtgggg gaaatgccag atgaaaccaa ctcttgctct     3300

cactagttgt cagcttctct ggataagtga ccacagaagc aggagtcctc ctgcttgggc     3360

atcattgggc cagttccttc tctttaaatc agatttgtaa tggctcccaa attccatcac     3420

atcacattta aattgcagac agtgttttgc acatcatgta tctgttttgt cccataatat     3480

gctttttact ccctgatccc agtttctgct gttgactctt ccattcagtt ttatttattg     3540

tgtgttctca cagtgacacc atttgtcctt ttctgcaaca acctttccag ctacttttgc     3600

caaattctat ttgtcttctc cttcaaaaca ttctcctttg cagttcctct tcatctgtgt     3660

agctgctctt ttgtctctta acttaccatt cctatagtac tttatgcatc tctgcttagt     3720

tctattagtt ttttggcctt gctcttctcc ttgattttaa aattccttct atagctagag     3780

cttttctttc tttcattctc tcttcctgca gtgttttgca tacatcagaa gctaggtaca     3840

taagttaaat gattgagagt tggctgtatt tagatttatc actttttaat agggtgagct     3900

tgagagtttt ctttctttct gttttttttt tttgtttttt tttttttttt tttttttttt     3960

ttttttgact aatttcacat gctctaaaaa ccttcaaagg tgattatttt tctcctggaa     4020

actccaggtc cattctgttt aaatccctaa gaatgtcaga attaaaataa cagggctatc     4080

ccgtaattgg aaatatttct tttttcagga tgctatagtc aatttagtaa gtgaccacca     4140

aattgttatt tgcactaaca aagctcaaaa cacgataagt ttactcctcc atctcagtaa     4200

taaaaattaa gctgtaatca accttctagg tttctcttgt cttaaaatgg gtattcaaaa     4260

atggggatct gtggtgtatg tatggaaaca catactcctt aatttacctg ttgttggaaa     4320

ctggagaaat gattgtcggg caaccgttta ttttttattg tattttattt ggttgaggga     4380

tttttttata aacagtttta cttgtgtcat attttaaaat tactaactgc catcacctgc     4440

tggggtcctt tgttaggtca ttttcagtga ctaataggga taatccaggt aactttgaag     4500

agatgagcag tgagtgacca ggcagttttt ctgcctttag ctttgacagt tcttaattaa     4560

gatcattgaa gaccagcttt ctcataaatt tctctttttg aaaaaaagaa agcatttgta     4620

ctaagctcct ctgtaagaca acatcttaaa tcttaaaagt gttgttatca tgactggtga     4680

gagaagaaaa cattttgttt ttattaaatg gagcattatt tacaaaaagc cattgttgag     4740

aattagatcc cacatcgtat aaatatctat taaccattct aaataaagag aactccagtg     4800

ttgctatgtg caagatcctc tcttggagct tttttgcata gcaattaaag gtgtgctatt     4860

tgtcagtagc catttttttg cagtgatttg aagaccaaag ttgttttaca gctgtgttac     4920

cgttaaaggt tttttttttt atatgtatta aatcaattta tcactgttta aagctttgaa     4980

tatctgcaat ctttgccaag gtactttttt atttaaaaaa aaacataact ttgtaaatat     5040

taccctgtaa tattatatat acttaataaa acattttaag ctattttgtt gggctatttc     5100

tattgctgct acagcagacc acaagcacat ttctgaaaaa tttaatttat taatgtattt     5160

ttaagttgct tatattctag gtaacaatgt aaagaatgat ttaaaatatt aattatgaat     5220

tttttgagta taatacccaa taagctttta attagagcag agttttaatt aaaagtttta     5280

aatcagtc                                                              5288


<210>  5
<211>  324
<212>  PRT
<213>  Mus musculus

<220>
<223>  leukocyte surface antigen CD47 isoform 4 precursor

<300>
<308>  NP_034711.1
<309>  2020-08-27
<313>  (1)..(324)

<400>  5

Met Trp Pro Leu Ala Ala Ala Leu Leu Leu Gly Ser Cys Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Ser Asn Val Asn Ser Ile Glu Phe Thr Ser 
            20                  25                  30          


Cys Asn Glu Thr Val Val Ile Pro Cys Ile Val Arg Asn Val Glu Ala 
        35                  40                  45              


Gln Ser Thr Glu Glu Met Phe Val Lys Trp Lys Leu Asn Lys Ser Tyr 
    50                  55                  60                  


Ile Phe Ile Tyr Asp Gly Asn Lys Asn Ser Thr Thr Thr Asp Gln Asn 
65                  70                  75                  80  


Phe Thr Ser Ala Lys Ile Ser Val Ser Asp Leu Ile Asn Gly Ile Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Arg Asp Ala Met Val Gly Asn Tyr Thr Cys 
            100                 105                 110         


Glu Val Thr Glu Leu Ser Arg Glu Gly Lys Thr Val Ile Glu Leu Lys 
        115                 120                 125             


Asn Arg Thr Ala Phe Asn Thr Asp Gln Gly Ser Ala Cys Ser Tyr Glu 
    130                 135                 140                 


Glu Glu Lys Gly Gly Cys Lys Leu Val Ser Trp Phe Ser Pro Asn Glu 
145                 150                 155                 160 


Lys Ile Leu Ile Val Ile Phe Pro Ile Leu Ala Ile Leu Leu Phe Trp 
                165                 170                 175     


Gly Lys Phe Gly Ile Leu Thr Leu Lys Tyr Lys Ser Ser His Thr Asn 
            180                 185                 190         


Lys Arg Ile Ile Leu Leu Leu Val Ala Gly Leu Val Leu Thr Val Ile 
        195                 200                 205             


Val Val Val Gly Ala Ile Leu Leu Ile Pro Gly Glu Lys Pro Val Lys 
    210                 215                 220                 


Asn Ala Ser Gly Leu Gly Leu Ile Val Ile Ser Thr Gly Ile Leu Ile 
225                 230                 235                 240 


Leu Leu Gln Tyr Asn Val Phe Met Thr Ala Phe Gly Met Thr Ser Phe 
                245                 250                 255     


Thr Ile Ala Ile Leu Ile Thr Gln Val Leu Gly Tyr Val Leu Ala Leu 
            260                 265                 270         


Val Gly Leu Cys Leu Cys Ile Met Ala Cys Glu Pro Val His Gly Pro 
        275                 280                 285             


Leu Leu Ile Ser Gly Leu Gly Ile Ile Ala Leu Ala Glu Leu Leu Gly 
    290                 295                 300                 


Leu Val Tyr Met Lys Phe Val Ala Ser Asn Gln Arg Thr Ile Gln Pro 
305                 310                 315                 320 


Pro Arg Asn Arg 
                

<210>  6
<211>  312
<212>  PRT
<213>  Homo sapiens

<220>
<223>  leukocyte surface antigen CD47 isoform 3 

<300>
<308>  NP_001369235.1
<309>  2020-10-04
<313>  (1)..(312)

<400>  6

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Glu 
305                 310         


<210>  7
<211>  293
<212>  PRT
<213>  Homo sapiens

<220>
<223>  leukocyte surface antigen CD47 isoform X2

<300>
<308>  XP_005247966.1
<309>  2020-08-17
<313>  (1)..(293)

<400>  7

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Glu 
    290             


<210>  8
<211>  5008
<212>  DNA
<213>  Homo sapiens

<220>
<223>  PREDICTED: Homo sapiens CD47 molecule (CD47), transcript 
variant X11, mRNA

<300>
<308>  XM_005247909.2
<309>  2020-08-17
<313>  (1)..(5008)

<400>  8
gtgcgcgcgg ccgtgcagcc tgggcagtgg gtcctgcctg tgacgcgcgg cggcggtcgg       60

tcctgcctgt aacggcggcg gcggctgctg ctccggacac ctgcggcggc ggcggcgacc      120

ccgcggcggg cgcggagatg tggcccctgg tagcggcgct gttgctgggc tcggcgtgct      180

gcggatcagc tcagctacta tttaataaaa caaaatctgt agaattcacg ttttgtaatg      240

acactgtcgt cattccatgc tttgttacta atatggaggc acaaaacact actgaagtat      300

acgtaaagtg gaaatttaaa ggaagagata tttacacctt tgatggagct ctaaacaagt      360

ccactgtccc cactgacttt agtagtgcaa aaattgaagt ctcacaatta ctaaaaggag      420

atgcctcttt gaagatggat aagagtgatg ctgtctcaca cacaggaaac tacacttgtg      480

aagtaacaga attaaccaga gaaggtgaaa cgatcatcga gctaaaatat cgtgttgttt      540

catggttttc tccaaatgaa aatattctta ttgttatttt cccaattttt gctatactcc      600

tgttctgggg acagtttggt attaaaacac ttaaatatag atccggtggt atggatgaga      660

aaacaattgc tttacttgtt gctggactag tgatcactgt cattgtcatt gttggagcca      720

ttcttttcgt cccaggtgaa tattcattaa agaatgctac tggccttggt ttaattgtga      780

cttctacagg gatattaata ttacttcact actatgtgtt tagtacagcg attggattaa      840

cctccttcgt cattgccata ttggttattc aggtgatagc ctatatcctc gctgtggttg      900

gactgagtct ctgtattgcg gcgtgtatac caatgcatgg ccctcttctg atttcaggtt      960

tgagtatctt agctctagca caattacttg gactagttta tatgaaattt gtggaataac     1020

tgaagtgaag tgatggactc cgatttggag agtagtaaga cgtgaaagga atacacttgt     1080

gtttaagcac catggccttg atgattcact gttggggaga agaaacaaga aaagtaactg     1140

gttgtcacct atgagaccct tacgtgattg ttagttaagt ttttattcaa agcagctgta     1200

atttagttaa taaaataatt atgatctatg ttgtttgccc aattgagatc cagttttttg     1260

ttgttatttt taatcaatta ggggcaatag tagaatggac aatttccaag aatgatgcct     1320

ttcaggtcct agggcctctg gcctctaggt aaccagttta aattggttca gggtgataac     1380

tacttagcac tgccctggtg attacccaga gatatctatg aaaaccagtg gcttccatca     1440

aacctttgcc aactcaggtt cacagcagct ttgggcagtt atggcagtat ggcattagct     1500

gagaggtgtc tgccacttct gggtcaatgg aataataaat taagtacagg caggaatttg     1560

gttgggagca tcttgtatga tctccgtatg atgtgatatt gatggagata gtggtcctca     1620

ttcttggggg ttgccattcc cacattcccc cttcaacaaa cagtgtaaca ggtccttccc     1680

agatttaggg tacttttatt gatggatatg ttttcctttt attcacataa ccccttgaaa     1740

ccctgtcttg tcctcctgtt acttgcttct gctgtacaag atgtagcacc ttttctcctc     1800

tttgaacatg gtctagtgac acggtagcac cagttgcagg aaggagccag acttgttctc     1860

agagcactgt gttcacactt ttcagcaaaa atagctatgg ttgtaacata tgtattccct     1920

tcctctgatt tgaaggcaaa aatctacagt gtttcttcac ttcttttctg atctggggca     1980

tgaaaaaagc aagattgaaa tttgaactat gagtctcctg catggcaaca aaatgtgtgt     2040

caccatcagg ccaacaggcc agcccttgaa tggggattta ttactgttgt atctatgttg     2100

catgataaac attcatcacc ttcctcctgt agtcctgcct cgtactcccc ttcccctatg     2160

attgaaaagt aaacaaaacc cacatttcct atcctggtta gaagaaaatt aatgttctga     2220

cagttgtgat cgcctggagt acttttagac ttttagcatt cgttttttac ctgtttgtgg     2280

atgtgtgttt gtatgtgcat acgtatgaga taggcacatg catcttctgt atggacaaag     2340

gtggggtacc tacaggagag caaaggttaa ttttgtgctt ttagtaaaaa catttaaata     2400

caaagttctt tattgggtgg aattatattt gatgcaaata tttgatcact taaaactttt     2460

aaaacttcta ggtaatttgc cacgcttttt gactgctcac caataccctg taaaaatacg     2520

taattcttcc tgtttgtgta ataagatatt catatttgta gttgcattaa taatagttat     2580

ttcttagtcc atcagatgtt cccgtgtgcc tcttttatgc caaattgatt gtcatatttc     2640

atgttgggac caagtagttt gcccatggca aacctaaatt tatgacctgc tgaggcctct     2700

cagaaaactg agcatactag caagacagct cttcttgaaa aaaaaaatat gtatacacaa     2760

atatatacgt atatctatat atacgtatgt atatacacac atgtatattc ttccttgatt     2820

gtgtagctgt ccaaaataat aacatatata gagggagctg tattccttta tacaaatctg     2880

atggctcctg cagcactttt tccttctgaa aatatttaca ttttgctaac ctagtttgtt     2940

actttaaaaa tcagttttga tgaaaggagg gaaaagcaga tggacttgaa aaagatccaa     3000

gctcctatta gaaaaggtat gaaaatcttt atagtaaaat tttttataaa ctaaagttgt     3060

accttttaat atgtagtaaa ctctcattta tttggggttc gctcttggat ctcatccatc     3120

cattgtgttc tctttaatgc tgcctgcctt ttgaggcatt cactgcccta gacaatgcca     3180

ccagagatag tgggggaaat gccagatgaa accaactctt gctctcacta gttgtcagct     3240

tctctggata agtgaccaca gaagcaggag tcctcctgct tgggcatcat tgggccagtt     3300

ccttctcttt aaatcagatt tgtaatggct cccaaattcc atcacatcac atttaaattg     3360

cagacagtgt tttgcacatc atgtatctgt tttgtcccat aatatgcttt ttactccctg     3420

atcccagttt ctgctgttga ctcttccatt cagttttatt tattgtgtgt tctcacagtg     3480

acaccatttg tccttttctg caacaacctt tccagctact tttgccaaat tctatttgtc     3540

ttctccttca aaacattctc ctttgcagtt cctcttcatc tgtgtagctg ctcttttgtc     3600

tcttaactta ccattcctat agtactttat gcatctctgc ttagttctat tagttttttg     3660

gccttgctct tctccttgat tttaaaattc cttctatagc tagagctttt ctttctttca     3720

ttctctcttc ctgcagtgtt ttgcatacat cagaagctag gtacataagt taaatgattg     3780

agagttggct gtatttagat ttatcacttt ttaatagggt gagcttgaga gttttctttc     3840

tttctgtttt ttttttttgt tttttttttt tttttttttt tttttttttt tgactaattt     3900

cacatgctct aaaaaccttc aaaggtgatt atttttctcc tggaaactcc aggtccattc     3960

tgtttaaatc cctaagaatg tcagaattaa aataacaggg ctatcccgta attggaaata     4020

tttctttttt caggatgcta tagtcaattt agtaagtgac caccaaattg ttatttgcac     4080

taacaaagct caaaacacga taagtttact cctccatctc agtaataaaa attaagctgt     4140

aatcaacctt ctaggtttct cttgtcttaa aatgggtatt caaaaatggg gatctgtggt     4200

gtatgtatgg aaacacatac tccttaattt acctgttgtt ggaaactgga gaaatgattg     4260

tcgggcaacc gtttattttt tattgtattt tatttggttg agggattttt ttataaacag     4320

ttttacttgt gtcatatttt aaaattacta actgccatca cctgctgggg tcctttgtta     4380

ggtcattttc agtgactaat agggataatc caggtaactt tgaagagatg agcagtgagt     4440

gaccaggcag tttttctgcc tttagctttg acagttctta attaagatca ttgaagacca     4500

gctttctcat aaatttctct ttttgaaaaa aagaaagcat ttgtactaag ctcctctgta     4560

agacaacatc ttaaatctta aaagtgttgt tatcatgact ggtgagagaa gaaaacattt     4620

tgtttttatt aaatggagca ttatttacaa aaagccattg ttgagaatta gatcccacat     4680

cgtataaata tctattaacc attctaaata aagagaactc cagtgttgct atgtgcaaga     4740

tcctctcttg gagctttttt gcatagcaat taaaggtgtg ctatttgtca gtagccattt     4800

ttttgcagtg atttgaagac caaagttgtt ttacagctgt gttaccgtta aaggtttttt     4860

tttttatatg tattaaatca atttatcact gtttaaagct ttgaatatct gcaatctttg     4920

ccaaggtact tttttattta aaaaaaaaca taactttgta aatattaccc tgtaatatta     4980

tatatactta ataaaacatt ttaagcta                                        5008


<210>  9
<211>  5259
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens CD47 molecule (CD47), transcript variant 3, mRNA

<300>
<308>  NM_001382306.1
<309>  2020-10-04
<313>  (1)..(5259)

<400>  9
gcagcctggg cagtgggtcc tgcctgtgac gcgcggcggc ggtcggtcct gcctgtaacg       60

gcggcggcgg ctgctgctcc ggacacctgc ggcggcggcg gcgaccccgc ggcgggcgcg      120

gagatgtggc ccctggtagc ggcgctgttg ctgggctcgg cgtgctgcgg atcagctcag      180

ctactattta ataaaacaaa atctgtagaa ttcacgtttt gtaatgacac tgtcgtcatt      240

ccatgctttg ttactaatat ggaggcacaa aacactactg aagtatacgt aaagtggaaa      300

tttaaaggaa gagatattta cacctttgat ggagctctaa acaagtccac tgtccccact      360

gactttagta gtgcaaaaat tgaagtctca caattactaa aaggagatgc ctctttgaag      420

atggataaga gtgatgctgt ctcacacaca ggaaactaca cttgtgaagt aacagaatta      480

accagagaag gtgaaacgat catcgagcta aaatatcgtg ttgtttcatg gttttctcca      540

aatgaaaata ttcttattgt tattttccca atttttgcta tactcctgtt ctggggacag      600

tttggtatta aaacacttaa atatagatcc ggtggtatgg atgagaaaac aattgcttta      660

cttgttgctg gactagtgat cactgtcatt gtcattgttg gagccattct tttcgtccca      720

ggtgaatatt cattaaagaa tgctactggc cttggtttaa ttgtgacttc tacagggata      780

ttaatattac ttcactacta tgtgtttagt acagcgattg gattaacctc cttcgtcatt      840

gccatattgg ttattcaggt gatagcctat atcctcgctg tggttggact gagtctctgt      900

attgcggcgt gtataccaat gcatggccct cttctgattt caggtttgag tatcttagct      960

ctagcacaat tacttggact agtttatatg aaatttgtgg cttccaatca gaagactata     1020

caacctccta ggaaagctgt agaggaaccc cttaatgaat aactgaagtg aagtgatgga     1080

ctccgatttg gagagtagta agacgtgaaa ggaatacact tgtgtttaag caccatggcc     1140

ttgatgattc actgttgggg agaagaaaca agaaaagtaa ctggttgtca cctatgagac     1200

ccttacgtga ttgttagtta agtttttatt caaagcagct gtaatttagt taataaaata     1260

attatgatct atgttgtttg cccaattgag atccagtttt ttgttgttat ttttaatcaa     1320

ttaggggcaa tagtagaatg gacaatttcc aagaatgatg cctttcaggt cctagggcct     1380

ctggcctcta ggtaaccagt ttaaattggt tcagggtgat aactacttag cactgccctg     1440

gtgattaccc agagatatct atgaaaacca gtggcttcca tcaaaccttt gccaactcag     1500

gttcacagca gctttgggca gttatggcag tatggcatta gctgagaggt gtctgccact     1560

tctgggtcaa tggaataata aattaagtac aggcaggaat ttggttggga gcatcttgta     1620

tgatctccgt atgatgtgat attgatggag atagtggtcc tcattcttgg gggttgccat     1680

tcccacattc ccccttcaac aaacagtgta acaggtcctt cccagattta gggtactttt     1740

attgatggat atgttttcct tttattcaca taaccccttg aaaccctgtc ttgtcctcct     1800

gttacttgct tctgctgtac aagatgtagc accttttctc ctctttgaac atggtctagt     1860

gacacggtag caccagttgc aggaaggagc cagacttgtt ctcagagcac tgtgttcaca     1920

cttttcagca aaaatagcta tggttgtaac atatgtattc ccttcctctg atttgaaggc     1980

aaaaatctac agtgtttctt cacttctttt ctgatctggg gcatgaaaaa agcaagattg     2040

aaatttgaac tatgagtctc ctgcatggca acaaaatgtg tgtcaccatc aggccaacag     2100

gccagccctt gaatggggat ttattactgt tgtatctatg ttgcatgata aacattcatc     2160

accttcctcc tgtagtcctg cctcgtactc cccttcccct atgattgaaa agtaaacaaa     2220

acccacattt cctatcctgg ttagaagaaa attaatgttc tgacagttgt gatcgcctgg     2280

agtactttta gacttttagc attcgttttt tacctgtttg tggatgtgtg tttgtatgtg     2340

catacgtatg agataggcac atgcatcttc tgtatggaca aaggtggggt acctacagga     2400

gagcaaaggt taattttgtg cttttagtaa aaacatttaa atacaaagtt ctttattggg     2460

tggaattata tttgatgcaa atatttgatc acttaaaact tttaaaactt ctaggtaatt     2520

tgccacgctt tttgactgct caccaatacc ctgtaaaaat acgtaattct tcctgtttgt     2580

gtaataagat attcatattt gtagttgcat taataatagt tatttcttag tccatcagat     2640

gttcccgtgt gcctctttta tgccaaattg attgtcatat ttcatgttgg gaccaagtag     2700

tttgcccatg gcaaacctaa atttatgacc tgctgaggcc tctcagaaaa ctgagcatac     2760

tagcaagaca gctcttcttg aaaaaaaaaa tatgtataca caaatatata cgtatatcta     2820

tatatacgta tgtatataca cacatgtata ttcttccttg attgtgtagc tgtccaaaat     2880

aataacatat atagagggag ctgtattcct ttatacaaat ctgatggctc ctgcagcact     2940

ttttccttct gaaaatattt acattttgct aacctagttt gttactttaa aaatcagttt     3000

tgatgaaagg agggaaaagc agatggactt gaaaaagatc caagctccta ttagaaaagg     3060

tatgaaaatc tttatagtaa aattttttat aaactaaagt tgtacctttt aatatgtagt     3120

aaactctcat ttatttgggg ttcgctcttg gatctcatcc atccattgtg ttctctttaa     3180

tgctgcctgc cttttgaggc attcactgcc ctagacaatg ccaccagaga tagtggggga     3240

aatgccagat gaaaccaact cttgctctca ctagttgtca gcttctctgg ataagtgacc     3300

acagaagcag gagtcctcct gcttgggcat cattgggcca gttccttctc tttaaatcag     3360

atttgtaatg gctcccaaat tccatcacat cacatttaaa ttgcagacag tgttttgcac     3420

atcatgtatc tgttttgtcc cataatatgc tttttactcc ctgatcccag tttctgctgt     3480

tgactcttcc attcagtttt atttattgtg tgttctcaca gtgacaccat ttgtcctttt     3540

ctgcaacaac ctttccagct acttttgcca aattctattt gtcttctcct tcaaaacatt     3600

ctcctttgca gttcctcttc atctgtgtag ctgctctttt gtctcttaac ttaccattcc     3660

tatagtactt tatgcatctc tgcttagttc tattagtttt ttggccttgc tcttctcctt     3720

gattttaaaa ttccttctat agctagagct tttctttctt tcattctctc ttcctgcagt     3780

gttttgcata catcagaagc taggtacata agttaaatga ttgagagttg gctgtattta     3840

gatttatcac tttttaatag ggtgagcttg agagttttct ttctttctgt tttttttttt     3900

tgtttttttt tttttttttt tttttttttt ttttgactaa tttcacatgc tctaaaaacc     3960

ttcaaaggtg attatttttc tcctggaaac tccaggtcca ttctgtttaa atccctaaga     4020

atgtcagaat taaaataaca gggctatccc gtaattggaa atatttcttt tttcaggatg     4080

ctatagtcaa tttagtaagt gaccaccaaa ttgttatttg cactaacaaa gctcaaaaca     4140

cgataagttt actcctccat ctcagtaata aaaattaagc tgtaatcaac cttctaggtt     4200

tctcttgtct taaaatgggt attcaaaaat ggggatctgt ggtgtatgta tggaaacaca     4260

tactccttaa tttacctgtt gttggaaact ggagaaatga ttgtcgggca accgtttatt     4320

ttttattgta ttttatttgg ttgagggatt tttttataaa cagttttact tgtgtcatat     4380

tttaaaatta ctaactgcca tcacctgctg gggtcctttg ttaggtcatt ttcagtgact     4440

aatagggata atccaggtaa ctttgaagag atgagcagtg agtgaccagg cagtttttct     4500

gcctttagct ttgacagttc ttaattaaga tcattgaaga ccagctttct cataaatttc     4560

tctttttgaa aaaaagaaag catttgtact aagctcctct gtaagacaac atcttaaatc     4620

ttaaaagtgt tgttatcatg actggtgaga gaagaaaaca ttttgttttt attaaatgga     4680

gcattattta caaaaagcca ttgttgagaa ttagatccca catcgtataa atatctatta     4740

accattctaa ataaagagaa ctccagtgtt gctatgtgca agatcctctc ttggagcttt     4800

tttgcatagc aattaaaggt gtgctatttg tcagtagcca tttttttgca gtgatttgaa     4860

gaccaaagtt gttttacagc tgtgttaccg ttaaaggttt ttttttttat atgtattaaa     4920

tcaatttatc actgtttaaa gctttgaata tctgcaatct ttgccaaggt acttttttat     4980

ttaaaaaaaa acataacttt gtaaatatta ccctgtaata ttatatatac ttaataaaac     5040

attttaagct attttgttgg gctatttcta ttgctgctac agcagaccac aagcacattt     5100

ctgaaaaatt taatttatta atgtattttt aagttgctta tattctaggt aacaatgtaa     5160

agaatgattt aaaatattaa ttatgaattt tttgagtata atacccaata agcttttaat     5220

tagagcagag ttttaattaa aagttttaaa tcagtccaa                            5259


