                         б
<110>  Ŵҩݣ޹˾
<120>  Թ״ͻ׵ĵ¡弰;
<130>  
<160>  70    
<170>  PatentIn汾3.3
<210>  1
<211>  360
<212>  DNA
<213>  ˹
<220>  
<223>  P5-22VH
<400>  1
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc     60
tcctgtgcag cctctggatt caccttcagg gactacgaca tcatctggat ccgccaggct    120
ccagggaagg ggctggagtg ggtttcatac attagtcgta gtggtagtac catatactac    180
tcagactctg tgaggggccg attcaccatc tccagggaca acgccaagaa ttcagtgtat    240
ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagatttc    300
gggtttgagg gaccccgtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca    360
<210>  2
<211>  120
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22VH
<400>  2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          
Asp Ile Ile Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Arg Ser Gly Ser Thr Ile Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Phe Gly Phe Glu Gly Pro Arg Met Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 
<210>  3
<211>  321
<212>  DNA
<213>  ˹
<220>  
<223>  P5-22VL
<400>  3
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60
atcacttgcc aggcgagtca ggacattaag aactatttaa attggtatca gcagaaacca    120
gggaaagccc ctaagctcct gatctacgat gcatccaatt tggaaacagg ggtcccatca    180
aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct    240
gaagatattg caacatatta ctgtcaacag tttgataatc tcccgatcac cttcggccaa    300
gggacacgac tggagattaa a                                              321
<210>  4
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22VL
<400>  4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Lys Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Phe Asp Asn Leu Pro Ile 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         
<210>  5
<211>  384
<212>  DNA
<213>  ˹
<220>  
<223>  P14-44VH
<400>  5
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt     60
tcctgcaagg catctggata cattttcacc agctattcta tgcactgggt gcgacaggcc    120
cctggacaag ggcttgagtg gatgggaaca atcaagccta gtgatgatag cacaaactac    180
gcacagaagt tccagggcag agtctccatg accagggaca cgtccacgag cacagtctac    240
atggagctga gcagcctgag atatgaggac acggccgtgt attactgtgc gagagaggcc    300
cggggatatt atgatagaag tggttattac cacccgggtt actttgacta ctggggccag    360
ggaaccctgg tcaccgtctc ctca                                           384
<210>  6
<211>  128
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44VH
<400>  6
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Ser Tyr 
            20                  25                  30          
Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Thr Ile Lys Pro Ser Asp Asp Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Ser Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Glu Ala Arg Gly Tyr Tyr Asp Arg Ser Gly Tyr Tyr His Pro 
            100                 105                 110         
Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             
<210>  7
<211>  330
<212>  DNA
<213>  ˹
<220>  
<223>  P14-44VL 
<400>  7
cagtctgtgc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc     60
tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacag    120
cacccaggca aagcccccaa actcatgatt tatgaggtca gtgatcggcc ctcaggggtt    180
tctagtcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc    240
caggctgagg acgaggctga ttattactgc ttctcatata caaccagcac cacttgggtg    300
ttcggcggag ggaccaagct gaccgtccta                                     330
<210>  8
<211>  110
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44VL
<400>  8
Gln Ser Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          
Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Met Ile Tyr Glu Val Ser Asp Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Phe Ser Tyr Thr Thr Ser 
                85                  90                  95      
Thr Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 
<210>  9
<211>  384
<212>  DNA
<213>  ˹
<220>  
<223>  P15-16VH
<400>  9
caggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgacactc     60
tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagct    120
ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtac catagactat    180
gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat    240
ctgcaaatga acagtctgag agctgaggac acggccttgt attactgtgc aaccctccca    300
cgtgaacgtg catatagtgg ctacgatcga atcttctaca ctatagacgt ctggggccaa    360
gggaccacgg tcaccgtctc ctca                                           384
<210>  10
<211>  128
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16VH 
<400>  10
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Thr Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      
Ala Thr Leu Pro Arg Glu Arg Ala Tyr Ser Gly Tyr Asp Arg Ile Phe 
            100                 105                 110         
Tyr Thr Ile Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125             
<210>  11
<211>  321
<212>  DNA
<213>  ˹
<220>  
<223>  P15-16VL
<400>  11
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60
atcacttgcc gggcaagtca gagcattagc acctatttaa attggtatca gcagaaacca    120
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180
aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct    240
gaagattttg caacctacta ctgtcaacag agttacagta cccctctcac tttcggcgga    300
gggaccaagg tggaaatcaa a                                              321
<210>  12
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16VL
<400>  12
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         
<210>  13
<211>  369
<212>  DNA
<213>  ˹
<220>  
<223>  P10-20VH
<400>  13
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc     60
tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct    120
ccagggaagg ggctggagtg ggtttcatac attagtatta gtagtactta cacaaactac    180
gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat    240
ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgt gatagcagca    300
gctggtaagg gtcactacta ctacggtatg gacgtctggg gccaagggac cacggtcacc    360
gtctcctca                                                            369
<210>  14
<211>  123
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20VH 
<400>  14
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Tyr Ile Ser Ile Ser Ser Thr Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Val Ile Ala Ala Ala Gly Lys Gly His Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             
<210>  15
<211>  321
<212>  DNA
<213>  ˹
<220>  
<223>  P10-20VL 
<400>  15
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60
atcacttgcc aggcgagtca ggacattagc aactatttaa attggtatca gcagaaacca    120
gggaaagccc ctaagctcct gatctacgat gcatccagtt tggaaacagg ggtcccatca    180
aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct    240
gaagatattg caacatatta ctgtcaacag tatgataatc tcccgctcac tttcggcgga    300
gggaccaagg tggagatcaa a                                              321
<210>  16
<211>  107
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20VL
<400>  16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         
<210>  17
<211>  390
<212>  DNA
<213>  ˹
<220>  
<223>  P14-37VH
<400>  17
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc     60
tcctgtgccg cctctggatt cactttcagt aacgcctgga tgagctgggt ccgccaggct    120
ccagggaagg gcctggagtg ggttggccgt attaaaagga atagcgatgg tgggacaaca    180
gaccacgctg cacccgtgac aggcagattc atcatctcaa gagatgattc aaaaaacacg    240
ctgtatctgc aaatgaacag cctgagaacc gaggacacag ccgtctatta ctgtaccaca    300
gatctggata ctgtagttcg gcgagttgtt ataaccgatc atgatgcttt tgatatctgg    360
ggccaaggga caatggtcac cgtctcttca                                     390
<210>  18
<211>  130
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37VH 
<400>  18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Gly Arg Ile Lys Arg Asn Ser Asp Gly Gly Thr Thr Asp His Ala Ala 
    50                  55                  60                  
Pro Val Thr Gly Arg Phe Ile Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Thr Thr Asp Leu Asp Thr Val Val Arg Arg Val Val Ile Thr 
            100                 105                 110         
Asp His Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val 
        115                 120                 125             
Ser Ser 
    130 
<210>  19
<211>  324
<212>  DNA
<213>  ˹
<220>  
<223>  P14-37VL
<400>  19
gacatccaga tgacccagtc tccatcctcc ctatctgcat ctgtaggaga cagagtcacc     60
atcacttgcc gggcaagtca gagcattagc agctttttaa attggtatca gcagaaagca    120
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca    180
aggttcagtg gcagtggatc tgggacagat ttcagtctca ccatcagcaa tctgcaacct    240
gaagattttg caacttacta ctgtcaacag agttacagta ccccttcgat caccttcggc    300
caagggacac gactggagat taaa                                           324
<210>  20
<211>  108
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37VL 
<400>  20
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Phe 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ser 
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             
<210>  21
<211>  351
<212>  DNA
<213>  ˹
<220>  
<223>  P23-29VH
<400>  21
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc     60
acctgcactg tctctggtga ctccatcagc agtagtactt actactgggg ctggatccgc    120
cagcccccag ggaaggggct ggagtggatt gggagtatgt attatggtcg gagtacctac    180
tacaacccgt ccctcaagag tcgagtcacc gtatccgtag acacgtccaa gaaccagttg    240
tccctgaagg tgagctctgt gaccgccgca gacacggctg tctattactg tgcgagacat    300
ctgggtggcg ttgactactg gggccaggga accctggtca ccgtctcttc a             351
<210>  22
<211>  117
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29VH
<400>  22
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser Ser Ser 
            20                  25                  30          
Thr Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Ile Gly Ser Met Tyr Tyr Gly Arg Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Val Ser Val Asp Thr Ser Lys Asn Gln Leu 
65                  70                  75                  80  
Ser Leu Lys Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg His Leu Gly Gly Val Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         
<210>  23
<211>  324
<212>  DNA
<213>  ˹
<220>  
<223>  P23-29VL
<400>  23
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc     60
atcacttgcc gggcgagtca gggcattagc aattctttag cctggtatca gcaggaacca    120
gggaaagccc ctaagctcct gctctatgct gcatccacat tggaaagtgg ggtcccatcc    180
aggttcagtg gcagtgggtc tggggcggat tccactctca ccatcagcag cctgcagcct    240
gaagattttg caacttatta ctgtcaacag tattatagtg cctccgcgct cactttcggc    300
ggagggacca aggtggagat taaa                                           324
<210>  24
<211>  108
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29VL
<400>  24
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Glu Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Ala Asp Ser Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Ala Ser Ala 
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             
<210>  25
<211>  354
<212>  DNA
<213>  ˹
<220>  
<223>  P3-11VH 
<400>  25
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60
tcctgtgcag cctctggaat caccgtcagt agcaactata tgagctgggt ccgccaggct    120
ccagggaagg ggctggaatg ggtctcagtt atttatagcg gtggtagcac attctacgca    180
gaccccgtga agggcagact caccatctcc agagacaatt ccaagaacac gctgtatctt    240
caaatgaaca gtgtgagagt cgaggacacg gctgtgtatt actgtgcgag aggagaagga    300
tgggagctgc catttgacta ctggggccag ggagccctgg tcaccgtctc ctca          354
<210>  26
<211>  118
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11VH
<400>  26
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Pro Val Lys 
    50                  55                  60                  
Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Val Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Glu Gly Trp Glu Leu Pro Phe Asp Tyr Trp Gly Gln Gly Ala 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             
<210>  27
<211>  330
<212>  DNA
<213>  ˹
<220>  
<223>  P3-11VL
<400>  27
cagtctgagc tgactcagcc tccctccgcg tccgggtctc ctggacagtc agtcaccatc     60
tcctgcactg gaaccagcag tgacgttggt ggtaataaat atgtctcctg gtaccaacag    120
cacccaggca aagcccccaa actcataatt tatgaggtca gtaagcggcc ctcaggggtc    180
cctgatcgct tctctggctc caagtctggc aacacggcct ccctgaccgt ctctgggctc    240
caggctgagg atgaggctga ttatcactgc agctcatatg caggcagcaa caatttggtg    300
ttcggcggag ggaccaagct gaccgtccta                                     330
<210>  28
<211>  110
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11VL
<400>  28
Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      
Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Asn 
            20                  25                  30          
Lys Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              
Ile Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  
Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 
65                  70                  75                  80  
Gln Ala Glu Asp Glu Ala Asp Tyr His Cys Ser Ser Tyr Ala Gly Ser 
                85                  90                  95      
Asn Asn Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 
<210>  29
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22HCDR1AbMţ 
<400>  29
Gly Phe Thr Phe Arg Asp Tyr Asp Ile Ile 
1               5                   10  
<210>  30
<211>  17
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22HCDR2Kabatţ
<400>  30
Tyr Ile Ser Arg Ser Gly Ser Thr Ile Tyr Tyr Ser Asp Ser Val Arg 
1               5                   10                  15      
Gly 
    
<210>  31
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22HCDR3Kabatţ
<400>  31
Asp Phe Gly Phe Glu Gly Pro Arg Met Asp Val 
1               5                   10      
<210>  32
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22LCDR1Kabatţ
<400>  32
Gln Ala Ser Gln Asp Ile Lys Asn Tyr Leu Asn 
1               5                   10      
<210>  33
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22LCDR2Kabatţ
<400>  33
Asp Ala Ser Asn Leu Glu Thr 
1               5           
<210>  34
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  P5-22LCDR3Kabatţ 
<400>  34
Gln Gln Phe Asp Asn Leu Pro Ile Thr 
1               5                   
<210>  35
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44HCDR1AbMţ 
<400>  35
Gly Tyr Ile Phe Thr Ser Tyr Ser Met His 
1               5                   10  
<210>  36
<211>  17
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44HCDR2Kabatţ
<400>  36
Thr Ile Lys Pro Ser Asp Asp Ser Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    
<210>  37
<211>  19
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44HCDR3Kabatţ
<400>  37
Glu Ala Arg Gly Tyr Tyr Asp Arg Ser Gly Tyr Tyr His Pro Gly Tyr 
1               5                   10                  15      
Phe Asp Tyr 
            
<210>  38
<211>  14
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44LCDR1Kabatţ
<400>  38
Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser 
1               5                   10                  
<210>  39
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44LCDR2Kabatţ
<400>  39
Glu Val Ser Asp Arg Pro Ser 
1               5           
<210>  40
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P14-44LCDR3Kabatţ
<400>  40
Phe Ser Tyr Thr Thr Ser Thr Thr Trp Val 
1               5                   10  
<210>  41
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16HCDR1AbMţ
<400>  41
Gly Phe Thr Phe Asp Asp Tyr Ala Met His 
1               5                   10  
<210>  42
<211>  17
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16HCDR2Kabatţ
<400>  42
Gly Ile Ser Trp Asn Ser Gly Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    
<210>  43
<211>  19
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16HCDR3Kabatţ
<400>  43
Leu Pro Arg Glu Arg Ala Tyr Ser Gly Tyr Asp Arg Ile Phe Tyr Thr 
1               5                   10                  15      
Ile Asp Val 
            
<210>  44
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16LCDR1Kabatţ
<400>  44
Arg Ala Ser Gln Ser Ile Ser Thr Tyr Leu Asn 
1               5                   10      
<210>  45
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16LCDR2Kabatţ
<400>  45
Ala Ala Ser Ser Leu Gln Ser 
1               5           
<210>  46
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  P15-16LCDR3Kabatţ
<400>  46
Gln Gln Ser Tyr Ser Thr Pro Leu Thr 
1               5                   
<210>  47
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20HCDR1AbMţ
<400>  47
Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
1               5                   10  
<210>  48
<211>  17
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20HCDR2Kabatţ
<400>  48
Tyr Ile Ser Ile Ser Ser Thr Tyr Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    
<210>  49
<211>  14
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20HCDR3Kabatţ
<400>  49
Ala Ala Ala Gly Lys Gly His Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  
<210>  50
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20LCDR1Kabatţ
<400>  50
Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      
<210>  51
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20LCDR2Kabatţ
<400>  51
Asp Ala Ser Ser Leu Glu Thr 
1               5           
<210>  52
<211>  9
<212>  PRT
<213>  ˹
<220>  
<223>  P10-20LCDR3Kabatţ
<400>  52
Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   
<210>  53
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37HCDR1AbMţ
<400>  53
Gly Phe Thr Phe Ser Asn Ala Trp Met Ser 
1               5                   10  
<210>  54
<211>  19
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37HCDR2Kabatţ
<400>  54
Arg Ile Lys Arg Asn Ser Asp Gly Gly Thr Thr Asp His Ala Ala Pro 
1               5                   10                  15      
Val Thr Gly 
            
<210>  55
<211>  19
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37HCDR3Kabatţ
<400>  55
Asp Leu Asp Thr Val Val Arg Arg Val Val Ile Thr Asp His Asp Ala 
1               5                   10                  15      
Phe Asp Ile 
            
<210>  56
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37LCDR1Kabatţ
<400>  56
Arg Ala Ser Gln Ser Ile Ser Ser Phe Leu Asn 
1               5                   10      
<210>  57
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37LCDR2Kabatţ
<400>  57
Ala Ala Ser Ser Leu Gln Ser 
1               5           
<210>  58
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P14-37LCDR3Kabatţ
<400>  58
Gln Gln Ser Tyr Ser Thr Pro Ser Ile Thr 
1               5                   10  
<210>  59
<211>  12
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29HCDR1AbMţ
<400>  59
Gly Asp Ser Ile Ser Ser Ser Thr Tyr Tyr Trp Gly 
1               5                   10          
<210>  60
<211>  16
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29HCDR2Kabatţ
<400>  60
Ser Met Tyr Tyr Gly Arg Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      
<210>  61
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29HCDR3Kabatţ
<400>  61
His Leu Gly Gly Val Asp Tyr 
1               5           
<210>  62
<211>  11
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29LCDR1Kabatţ
<400>  62
Arg Ala Ser Gln Gly Ile Ser Asn Ser Leu Ala 
1               5                   10      
<210>  63
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29LCDR2Kabatţ
<400>  63
Ala Ala Ser Thr Leu Glu Ser 
1               5           
<210>  64
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P23-29LCDR3Kabatţ
<400>  64
Gln Gln Tyr Tyr Ser Ala Ser Ala Leu Thr 
1               5                   10  
<210>  65
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11HCDR1AbMţ
<400>  65
Gly Ile Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   10  
<210>  66
<211>  16
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11HCDR2Kabatţ
<400>  66
Val Ile Tyr Ser Gly Gly Ser Thr Phe Tyr Ala Asp Pro Val Lys Gly 
1               5                   10                  15      
<210>  67
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11HCDR3Kabatţ
<400>  67
Gly Glu Gly Trp Glu Leu Pro Phe Asp Tyr 
1               5                   10  
<210>  68
<211>  14
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11LCDR1Kabatţ
<400>  68
Thr Gly Thr Ser Ser Asp Val Gly Gly Asn Lys Tyr Val Ser 
1               5                   10                  
<210>  69
<211>  7
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11LCDR2Kabatţ
<400>  69
Glu Val Ser Lys Arg Pro Ser 
1               5           
<210>  70
<211>  10
<212>  PRT
<213>  ˹
<220>  
<223>  P3-11LCDR3Kabatţ
<400>  70
Ser Ser Tyr Ala Gly Ser Asn Asn Leu Val 
1               5                   10  


