               SEQUENCE LISTING

<110> Ichnos Sciences SA

<120> Antibodies that bind to IL1RAP and uses thereof

<130> ISB 880 01 EP00

<160> 349

<170> BiSSAP 1.3.6

<210> 1
<211> 373
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 1 - human (hs)IL-1RAP-ECD(S21-E359)-Avi-His

<400> 1
Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met Arg Gln Ile Gln 
1               5                   10                  15      
Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro Leu Phe Glu His 
            20                  25                  30          
Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala Gly Leu Thr Leu 
        35                  40                  45              
Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu Glu Pro Ile Asn 
    50                  55                  60                  
Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys Asp Val Leu Trp 
65                  70                  75                  80  
Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu 
                85                  90                  95      
Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro Leu Glu Val Val 
            100                 105                 110         
Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu Pro Val His Lys 
        115                 120                 125             
Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys Pro Asn Val Asp 
    130                 135                 140                 
Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr Trp Tyr Met Gly 
145                 150                 155                 160 
Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro Glu Gly Met Asn 
                165                 170                 175     
Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly Asn Tyr Thr Cys 
            180                 185                 190         
Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His Leu Thr Arg Thr 
        195                 200                 205             
Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala Val Pro Pro Val 
    210                 215                 220                 
Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys Glu Pro Gly Glu 
225                 230                 235                 240 
Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe Leu Met Asp Ser 
                245                 250                 255     
Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys Pro Asp Asp Ile 
            260                 265                 270         
Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His Ser Arg Thr Glu 
        275                 280                 285             
Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys Val Thr Ser Glu 
    290                 295                 300                 
Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser Ala Lys Gly Glu 
305                 310                 315                 320 
Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro Ala Pro Arg Tyr 
                325                 330                 335     
Thr Val Glu Gly Gly Gly Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu 
            340                 345                 350         
Ala Gln Lys Ile Glu Trp His Glu Gly Gly Gly His His His His His 
        355                 360                 365             
His His His His His 
    370             

<210> 2
<211> 373
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 2 - cynomolgus monkey
      (cyno)IL-1RAP-ECD(S21-E359)-Avi-His

<400> 2
Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met Arg Gln Ile Gln 
1               5                   10                  15      
Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro Leu Phe Glu His 
            20                  25                  30          
Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala Gly Leu Thr Leu 
        35                  40                  45              
Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu Glu Pro Ile Asn 
    50                  55                  60                  
Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys Asp Val Leu Trp 
65                  70                  75                  80  
Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu 
                85                  90                  95      
Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro Leu Glu Val Val 
            100                 105                 110         
Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu Pro Val His Lys 
        115                 120                 125             
Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys Pro Asn Val Asp 
    130                 135                 140                 
Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr Trp Tyr Met Gly 
145                 150                 155                 160 
Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro Glu Gly Met Asn 
                165                 170                 175     
Leu Ser Phe Leu Ile Ala Phe Ile Ser Asn Asn Gly Asn Tyr Thr Cys 
            180                 185                 190         
Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His Leu Thr Arg Thr 
        195                 200                 205             
Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala Val Pro Pro Val 
    210                 215                 220                 
Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys Glu Pro Gly Glu 
225                 230                 235                 240 
Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe Leu Met Asp Ser 
                245                 250                 255     
Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys Pro Asp Asp Ile 
            260                 265                 270         
Pro Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His Ser Arg Thr Glu 
        275                 280                 285             
Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys Val Thr Ser Glu 
    290                 295                 300                 
Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser Ala Lys Gly Glu 
305                 310                 315                 320 
Val Ala Lys Ala Ala Thr Val Lys Gln Lys Val Pro Ala Pro Arg Tyr 
                325                 330                 335     
Thr Val Glu Gly Gly Gly Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu 
            340                 345                 350         
Ala Gln Lys Ile Glu Trp His Glu Gly Gly Gly His His His His His 
        355                 360                 365             
His His His His His 
    370             

<210> 3
<211> 373
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 3 - chicken (gg)IL-1RAP-ECD(S139-E478)-Avi-His

<400> 3
Ser Glu Arg Cys Asp Asp Trp Gly Val Asp Thr Met Lys Gln Ile Gln 
1               5                   10                  15      
Ile Tyr Asp Gly Glu Pro Ala Lys Ile Lys Cys Pro Leu Phe Glu Thr 
            20                  25                  30          
Phe Leu Lys Tyr Asn Tyr Ser Thr Ala His Ser Ala Gly Leu Thr Leu 
        35                  40                  45              
Ile Trp Tyr Arg Ile Gly Gln Asp Arg Asp Leu Glu Glu Pro Ile Asn 
    50                  55                  60                  
Phe Arg Leu Pro Asp Asn Arg Ile Ser Lys Glu Lys Asp Thr Leu Trp 
65                  70                  75                  80  
Phe Trp Pro Ala Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu 
                85                  90                  95      
Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro Leu Glu Val Val 
            100                 105                 110         
Pro Lys Asp Gln Gly Ser Cys Val Ser His Ser Ile Lys Pro Val Glu 
        115                 120                 125             
Gln Met Phe Tyr Leu Glu Tyr Ala Asn Glu Lys Ile Thr Cys Pro Asp 
    130                 135                 140                 
Ile Asp Gly Phe Tyr Pro Ala Ser Val Thr Pro Thr Val Lys Trp Tyr 
145                 150                 155                 160 
Gln Ser Cys Arg Leu Val Asp Gly Phe Asn Glu Arg His Pro Gln Gly 
                165                 170                 175     
Ser Lys Leu Val Ile Gly Val Val Arg Ser Ala Tyr Glu Gly Asn Tyr 
            180                 185                 190         
Thr Cys Ile Val Thr Phe Lys Asp His Gly Arg Thr Tyr Asn Leu Thr 
        195                 200                 205             
Arg Thr Val Lys Met Lys Val Val Gly Ser Pro Asn Lys Ala Leu Pro 
    210                 215                 220                 
Pro Gln Phe Thr Ser Pro Asn Glu Lys Val Val Tyr Glu Leu Glu Ala 
225                 230                 235                 240 
Gly Asp Asp Leu Val Leu Pro Cys Glu Val Phe Phe Thr Phe Leu Lys 
                245                 250                 255     
Asp Ser Arg Thr Glu Val Trp Trp Thr Ile Asp Gly Lys Asn Thr Asp 
            260                 265                 270         
Asp Ile Val Asp Ala Lys Val Thr Gln Ser Glu Ile Pro Arg Arg Phe 
        275                 280                 285             
Glu Asp Lys Thr Ile Ile Arg Thr Leu Thr Val Ala Lys Ala Thr Pro 
    290                 295                 300                 
Glu Asp Leu Lys Arg Asn Tyr Thr Cys Tyr Ala Arg Asn Ala Lys Gly 
305                 310                 315                 320 
Glu Gly His Ser Gln Ala Ile Val His Met Lys Val Ala Ala Pro Lys 
                325                 330                 335     
Tyr Thr Val Glu Gly Gly Gly Gly Thr Gly Gly Leu Asn Asp Ile Phe 
            340                 345                 350         
Glu Ala Gln Lys Ile Glu Trp His Glu Gly Gly Gly His His His His 
        355                 360                 365             
His His His His His 
    370             

<210> 4
<211> 373
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 4 - IL-1RAP-ECD(ggD1(S139-P246)-hsD2(V132-V233)-hsD3(
      V234-E359))-Avi-His

<400> 4
Ser Glu Arg Cys Asp Asp Trp Gly Val Asp Thr Met Lys Gln Ile Gln 
1               5                   10                  15      
Ile Tyr Asp Gly Glu Pro Ala Lys Ile Lys Cys Pro Leu Phe Glu Thr 
            20                  25                  30          
Phe Leu Lys Tyr Asn Tyr Ser Thr Ala His Ser Ala Gly Leu Thr Leu 
        35                  40                  45              
Ile Trp Tyr Arg Ile Gly Gln Asp Arg Asp Leu Glu Glu Pro Ile Asn 
    50                  55                  60                  
Phe Arg Leu Pro Asp Asn Arg Ile Ser Lys Glu Lys Asp Thr Leu Trp 
65                  70                  75                  80  
Phe Trp Pro Ala Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu 
                85                  90                  95      
Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro Leu Glu Val Val 
            100                 105                 110         
Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu Pro Val His Lys 
        115                 120                 125             
Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys Pro Asn Val Asp 
    130                 135                 140                 
Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr Trp Tyr Met Gly 
145                 150                 155                 160 
Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro Glu Gly Met Asn 
                165                 170                 175     
Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly Asn Tyr Thr Cys 
            180                 185                 190         
Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His Leu Thr Arg Thr 
        195                 200                 205             
Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala Val Pro Pro Val 
    210                 215                 220                 
Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys Glu Pro Gly Glu 
225                 230                 235                 240 
Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe Leu Met Asp Ser 
                245                 250                 255     
Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys Pro Asp Asp Ile 
            260                 265                 270         
Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His Ser Arg Thr Glu 
        275                 280                 285             
Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys Val Thr Ser Glu 
    290                 295                 300                 
Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser Ala Lys Gly Glu 
305                 310                 315                 320 
Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro Ala Pro Arg Tyr 
                325                 330                 335     
Thr Val Glu Gly Gly Gly Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu 
            340                 345                 350         
Ala Gln Lys Ile Glu Trp His Glu Gly Gly Gly His His His His His 
        355                 360                 365             
His His His His His 
    370             

<210> 5
<211> 373
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 5 - IL-1RAP-ECD(ggD1(S139-H260)-ggD2(S261-V349)-hsD3(
      V243-E359))-Avi-His

<400> 5
Ser Glu Arg Cys Asp Asp Trp Gly Val Asp Thr Met Lys Gln Ile Gln 
1               5                   10                  15      
Ile Tyr Asp Gly Glu Pro Ala Lys Ile Lys Cys Pro Leu Phe Glu Thr 
            20                  25                  30          
Phe Leu Lys Tyr Asn Tyr Ser Thr Ala His Ser Ala Gly Leu Thr Leu 
        35                  40                  45              
Ile Trp Tyr Arg Ile Gly Gln Asp Arg Asp Leu Glu Glu Pro Ile Asn 
    50                  55                  60                  
Phe Arg Leu Pro Asp Asn Arg Ile Ser Lys Glu Lys Asp Thr Leu Trp 
65                  70                  75                  80  
Phe Trp Pro Ala Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu 
                85                  90                  95      
Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro Leu Glu Val Val 
            100                 105                 110         
Pro Lys Asp Gln Gly Ser Cys Val Ser His Ser Ile Lys Pro Val Glu 
        115                 120                 125             
Gln Met Phe Tyr Leu Glu Tyr Ala Asn Glu Lys Ile Thr Cys Pro Asp 
    130                 135                 140                 
Ile Asp Gly Phe Tyr Pro Ala Ser Val Thr Pro Thr Val Lys Trp Tyr 
145                 150                 155                 160 
Gln Ser Cys Arg Leu Val Asp Gly Phe Asn Glu Arg His Pro Gln Gly 
                165                 170                 175     
Ser Lys Leu Val Ile Gly Val Val Arg Ser Ala Tyr Glu Gly Asn Tyr 
            180                 185                 190         
Thr Cys Ile Val Thr Phe Lys Asp His Gly Arg Thr Tyr Asn Leu Thr 
        195                 200                 205             
Arg Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala Val Pro Pro Val 
    210                 215                 220                 
Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys Glu Pro Gly Glu 
225                 230                 235                 240 
Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe Leu Met Asp Ser 
                245                 250                 255     
Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys Pro Asp Asp Ile 
            260                 265                 270         
Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His Ser Arg Thr Glu 
        275                 280                 285             
Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys Val Thr Ser Glu 
    290                 295                 300                 
Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser Ala Lys Gly Glu 
305                 310                 315                 320 
Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro Ala Pro Arg Tyr 
                325                 330                 335     
Thr Val Glu Gly Gly Gly Gly Thr Gly Gly Leu Asn Asp Ile Phe Glu 
            340                 345                 350         
Ala Gln Lys Ile Glu Trp His Glu Gly Gly Gly His His His His His 
        355                 360                 365             
His His His His His 
    370             

<210> 6
<211> 550
<212> PRT
<213> Homo sapiens


<220> 
<223> >SEQ ID NO: 6 - human IL-1RAP, full length

<400> 6
Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met Arg Gln Ile Gln 
1               5                   10                  15      
Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro Leu Phe Glu His 
            20                  25                  30          
Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala Gly Leu Thr Leu 
        35                  40                  45              
Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu Glu Pro Ile Asn 
    50                  55                  60                  
Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys Asp Val Leu Trp 
65                  70                  75                  80  
Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu 
                85                  90                  95      
Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro Leu Glu Val Val 
            100                 105                 110         
Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu Pro Val His Lys 
        115                 120                 125             
Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys Pro Asn Val Asp 
    130                 135                 140                 
Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr Trp Tyr Met Gly 
145                 150                 155                 160 
Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro Glu Gly Met Asn 
                165                 170                 175     
Leu Ser Phe Leu Ile Ala Leu Ile Ser Asn Asn Gly Asn Tyr Thr Cys 
            180                 185                 190         
Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His Leu Thr Arg Thr 
        195                 200                 205             
Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala Val Pro Pro Val 
    210                 215                 220                 
Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys Glu Pro Gly Glu 
225                 230                 235                 240 
Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe Leu Met Asp Ser 
                245                 250                 255     
Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys Pro Asp Asp Ile 
            260                 265                 270         
Thr Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His Ser Arg Thr Glu 
        275                 280                 285             
Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys Val Thr Ser Glu 
    290                 295                 300                 
Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser Ala Lys Gly Glu 
305                 310                 315                 320 
Val Ala Lys Ala Ala Lys Val Lys Gln Lys Val Pro Ala Pro Arg Tyr 
                325                 330                 335     
Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val Leu Leu Val Val 
            340                 345                 350         
Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu Met Val Leu Phe 
        355                 360                 365             
Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu Asp Gly Lys Glu 
    370                 375                 380                 
Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu Glu Glu Glu Phe 
385                 390                 395                 400 
Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu Phe Gly Tyr Lys 
                405                 410                 415     
Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly Ile Val Thr Asp 
            420                 425                 430         
Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu Leu Val Val Leu 
        435                 440                 445             
Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu Leu Glu Leu Lys 
    450                 455                 460                 
Ala Gly Leu Glu Asn Met Ala Ser Arg Gly Asn Ile Asn Val Ile Leu 
465                 470                 475                 480 
Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys Glu Leu Lys Arg 
                485                 490                 495     
Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly Glu Lys Ser Lys 
            500                 505                 510         
Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val Ala Met Pro Val 
        515                 520                 525             
Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln Gly Leu Ser Tyr 
    530                 535                 540                 
Ser Ser Leu Lys Asn Val 
545                 550 

<210> 7
<211> 550
<212> PRT
<213> Macaca fascicularis


<220> 
<223> >SEQ ID NO: 7 - cynomolgus monkey IL-1RAP, full length

<400> 7
Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met Arg Gln Ile Gln 
1               5                   10                  15      
Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro Leu Phe Glu His 
            20                  25                  30          
Phe Leu Lys Phe Asn Tyr Ser Thr Ala His Ser Ala Gly Leu Thr Leu 
        35                  40                  45              
Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu Glu Pro Ile Asn 
    50                  55                  60                  
Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys Asp Val Leu Trp 
65                  70                  75                  80  
Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr Thr Cys Met Leu 
                85                  90                  95      
Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro Leu Glu Val Val 
            100                 105                 110         
Gln Lys Asp Ser Cys Phe Asn Ser Pro Met Lys Leu Pro Val His Lys 
        115                 120                 125             
Leu Tyr Ile Glu Tyr Gly Ile Gln Arg Ile Thr Cys Pro Asn Val Asp 
    130                 135                 140                 
Gly Tyr Phe Pro Ser Ser Val Lys Pro Thr Ile Thr Trp Tyr Met Gly 
145                 150                 155                 160 
Cys Tyr Lys Ile Gln Asn Phe Asn Asn Val Ile Pro Glu Gly Met Asn 
                165                 170                 175     
Leu Ser Phe Leu Ile Ala Phe Ile Ser Asn Asn Gly Asn Tyr Thr Cys 
            180                 185                 190         
Val Val Thr Tyr Pro Glu Asn Gly Arg Thr Phe His Leu Thr Arg Thr 
        195                 200                 205             
Leu Thr Val Lys Val Val Gly Ser Pro Lys Asn Ala Val Pro Pro Val 
    210                 215                 220                 
Ile His Ser Pro Asn Asp His Val Val Tyr Glu Lys Glu Pro Gly Glu 
225                 230                 235                 240 
Glu Leu Leu Ile Pro Cys Thr Val Tyr Phe Ser Phe Leu Met Asp Ser 
                245                 250                 255     
Arg Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys Pro Asp Asp Ile 
            260                 265                 270         
Pro Ile Asp Val Thr Ile Asn Glu Ser Ile Ser His Ser Arg Thr Glu 
        275                 280                 285             
Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys Val Thr Ser Glu 
    290                 295                 300                 
Asp Leu Lys Arg Ser Tyr Val Cys His Ala Arg Ser Ala Lys Gly Glu 
305                 310                 315                 320 
Val Ala Lys Ala Ala Thr Val Lys Gln Lys Val Pro Ala Pro Arg Tyr 
                325                 330                 335     
Thr Val Glu Leu Ala Cys Gly Phe Gly Ala Thr Val Leu Leu Val Val 
            340                 345                 350         
Ile Leu Ile Val Val Tyr His Val Tyr Trp Leu Glu Met Val Leu Phe 
        355                 360                 365             
Tyr Arg Ala His Phe Gly Thr Asp Glu Thr Ile Leu Asp Gly Lys Glu 
    370                 375                 380                 
Tyr Asp Ile Tyr Val Ser Tyr Ala Arg Asn Ala Glu Glu Glu Glu Phe 
385                 390                 395                 400 
Val Leu Leu Thr Leu Arg Gly Val Leu Glu Asn Glu Phe Gly Tyr Lys 
                405                 410                 415     
Leu Cys Ile Phe Asp Arg Asp Ser Leu Pro Gly Gly Ile Val Thr Asp 
            420                 425                 430         
Glu Thr Leu Ser Phe Ile Gln Lys Ser Arg Arg Leu Leu Val Val Leu 
        435                 440                 445             
Ser Pro Asn Tyr Val Leu Gln Gly Thr Gln Ala Leu Leu Glu Leu Lys 
    450                 455                 460                 
Ala Gly Leu Glu Asn Met Ala Ser Gln Gly Asn Ile Asn Val Ile Leu 
465                 470                 475                 480 
Val Gln Tyr Lys Ala Val Lys Glu Thr Lys Val Lys Glu Leu Lys Arg 
                485                 490                 495     
Ala Lys Thr Val Leu Thr Val Ile Lys Trp Lys Gly Glu Lys Ser Lys 
            500                 505                 510         
Tyr Pro Gln Gly Arg Phe Trp Lys Gln Leu Gln Val Ala Met Pro Val 
        515                 520                 525             
Lys Lys Ser Pro Arg Arg Ser Ser Ser Asp Glu Gln Gly Leu Ser Tyr 
    530                 535                 540                 
Ser Ser Leu Lys Asn Val 
545                 550 

<210> 8
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 8 - anti-IL-1Rap-UCP02-A4 FAB heavy chain

<400> 8
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Val Phe Ser Tyr Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Ile Pro Asp Phe Gly His Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Ser Pro Tyr Lys Gly Trp Trp Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 9
<211> 224
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 9 - anti-IL-1Rap-UCP02-A6 FAB heavy chain

<400> 9
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ala Phe Arg Ile Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Leu Ala Ser Gly Gly Gly Ala Val Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Lys Asp Ile Tyr Gly Tyr Gly Tyr Gly Asp Ile Trp Gly 
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 



<210> 10
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 10 - anti-IL-1Rap-UCP02-B11 FAB heavy chain

<400> 10
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly His Phe Ser Gln Phe 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ala Pro Gly Leu Gly Ser Thr Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Ser Ile Tyr Ser Ala Trp Leu Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 11
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 11 - anti-IL-1Rap-UCP02-B5 FAB heavy chain

<400> 11
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Tyr Phe Ser Ala Tyr 
            20                  25                  30          
Ile Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Val Pro Gln Tyr Gly Tyr Ala Thr Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Arg Ser Thr Thr Tyr Tyr Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 12
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 12 - anti-IL-1Rap-UCP02-C3 FAB heavy chain

<400> 12
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 13
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 13 - anti-IL-1Rap-UCP02-C5 FAB heavy chain

<400> 13
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly His Phe Asn Ile Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Ala Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Ser Ile Tyr His Gly Trp Met Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 14
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 14 - anti-IL-1Rap-UCP02-C8 FAB heavy chain

<400> 14
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Gln Phe Ser Glu Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 15
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 15 - anti-IL-1Rap-UCP02-C9 FAB heavy chain

<400> 15
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Val Phe Ser Tyr Tyr 
            20                  25                  30          
Ala Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Gly Tyr Gly Ala Thr Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Val Ser Tyr Ser Ser Gly Trp Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 16
<211> 226
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 16 - anti-IL-1Rap-UCP02-D2 FAB heavy chain

<400> 16
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Arg Phe Ser Asp Ser 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Leu Pro Gln Phe Gly Ala Pro Leu Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ser Tyr Tyr Gly Val Val Gly Tyr Val Pro Asp Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 
Ser Cys 
225     

<210> 17
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 17 - anti-IL-1Rap-UCP02-G11 FAB heavy chain

<400> 17
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Gln Phe Asn Asp Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ala Tyr Gly Gln Ala Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Pro Tyr Ser Thr Ala Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 18
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 18 - anti-IL-1Rap-UCP02-G3 FAB heavy chain

<400> 18
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Tyr Leu Asn Glu Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Val Ile Pro Arg Tyr Gly Gln Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Pro Leu Gly Tyr Ser Tyr Gly Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 19
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 19 - anti-IL-1Rap-UCP02-G8 FAB heavy chain

<400> 19
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Phe Phe Ser Ile Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ala Pro Ala Ala Gly Ile Ala Glu Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Ser Pro Gly Arg Val Arg Glu Glu Tyr Trp Tyr Asp 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             
Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 
Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 
Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     
Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         
Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             
Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 
Lys Ser Cys 
225         

<210> 20
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 20 - anti-IL-1Rap-UCP02-H8 FAB heavy chain

<400> 20
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Val Phe Ser Gly Tyr 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Glu Phe Gly Ala Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Ser Ser Ala Tyr Ser Pro Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 21
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 21 - anti-IL-1Rap-UCP02-H9 FAB heavy chain

<400> 21
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Ser Ser Tyr 
            20                  25                  30          
Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro His His Gly Ala Thr Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Pro Asp Val Tyr Thr Pro Trp Phe Asp Val Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 22
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 22 - anti-IL-1Rap-UCP03-A2 FAB heavy chain

<400> 22
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Lys Phe Asn Phe Asp 
            20                  25                  30          
Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Asp Phe Ala Ser Thr His Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Pro Asp Tyr Tyr Thr Gly Trp Met Ala Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 23
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 23 - anti-IL-1Rap-UCP03-A3 FAB heavy chain

<400> 23
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Leu Phe Asn Glu Asn 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Asp Val Gly Ala Ala Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ser Ile Tyr Thr Ala Trp Phe Ala Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 24
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 24 - anti-IL-1Rap-UCP03-B4 FAB heavy chain

<400> 24
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Ser Gln His 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Phe Glu Gly Val Ala Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Ser Ser Tyr Tyr Ser Trp Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 25
<211> 223
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 25 - anti-IL-1Rap-UCP03-B6 FAB heavy chain

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Pro Phe Ser Val Tyr 
            20                  25                  30          
Ile Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Ala Gln Gln Gly Ser Ala Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Pro Asp Pro Tyr Ser Gly His Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             
Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 
Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 
Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     
Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         
Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             
Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             

<210> 26
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 26 - anti-IL-1Rap-UCP03-C1 FAB heavy chain

<400> 26
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Arg Phe Ser Ser Asn 
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro His Phe Gly Ala Val Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Ser Val Tyr Thr Gly Trp Phe Asp Asn Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 27
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 27 - anti-IL-1Rap-UCP03-C2 FAB heavy chain

<400> 27
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Pro Phe Lys Arg Tyr 
            20                  25                  30          
Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Thr Thr Gly Glu Ala Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Gly Thr Thr Tyr Ala Ala Phe Asp His Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 28
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 28 - anti-IL-1Rap-UCP03-F4 FAB heavy chain

<400> 28
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Gly Phe Ser Glu Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Leu Pro Glu Gln Gly Ala Ala Tyr Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Val Gly Leu Tyr Val Pro Tyr Met Asp Ile Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 29
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 29 - anti-IL-1Rap-UCP03-G3 FAB heavy chain

<400> 29
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Leu Ser Gly Tyr 
            20                  25                  30          
Ala Phe His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Asn Phe Ala Gln Thr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Ser Ile Tyr Ser Gly Trp Ser Asp Val Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 30
<211> 222
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 30 - anti-IL-1Rap-UCP03-G4 FAB heavy chain

<400> 30
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Arg Phe Ser His Tyr 
            20                  25                  30          
Val Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Gly Ile Ile Pro Tyr Glu Gly Lys Pro Phe Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Asp Tyr Phe Tyr Tyr Tyr Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         

<210> 31
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 31 - anti-IL-1Rap-UCP04-C1 FAB heavy chain

<400> 31
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 
            20                  25                  30          
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Glu Gly Asp Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Leu Tyr Trp Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 32
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 32 - anti-IL-1Rap-C8-H1A-C4 FAB heavy chain

<400> 32
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Lys Leu Asn Ala Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 33
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 33 - anti-IL-1Rap-C8-H1A-C8 FAB heavy chain

<400> 33
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Leu Phe Ser Asp Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 34
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 34 - anti-IL-1Rap-C8-H1A-D8 FAB heavy chain

<400> 34
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly His Phe Asn Asn Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 35
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 35 - anti-IL-1Rap-C8-H1A-F1 FAB heavy chain

<400> 35
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ile Phe Ser Asn Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 36
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 36 - anti-IL-1Rap-C8-H1A-G11 FAB heavy chain

<400> 36
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Arg Phe His Gln Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 37
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 37 - anti-IL-1Rap-C8-H1A-G1 FAB heavy chain

<400> 37
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ala Ser Arg Ala Tyr 
            20                  25                  30          
Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 38
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 38 - anti-IL-1Rap-C8-H1A-G3 FAB heavy chain

<400> 38
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Ser Asp Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 39
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 39 - anti-IL-1Rap-C8-H1B-A8 FAB heavy chain

<400> 39
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Glu Gly Ser Tyr Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 40
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 40 - anti-IL-1Rap-C8-H1B-B10 FAB heavy chain

<400> 40
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Val Thr His Thr Ser Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 41
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 41 - anti-IL-1Rap-C8-H1B-B8 FAB heavy chain

<400> 41
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 42
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 42 - anti-IL-1Rap-C8-H1B-D8 FAB heavy chain

<400> 42
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Pro Ser Asn Pro Val Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 43
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 43 - anti-IL-1Rap-C8-H1B-E7 FAB heavy chain

<400> 43
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Lys His Gly Asn Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 44
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 44 - anti-IL-1Rap-C8-H1B-F3 FAB heavy chain

<400> 44
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro His Thr Ala His 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 45
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 45 - anti-IL-1Rap-C8-H1B-G10 FAB heavy chain

<400> 45
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Arg Arg Ala Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 46
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 46 - anti-IL-1Rap-C8-H1B-H10 FAB heavy chain

<400> 46
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Thr Trp Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 47
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 47 - anti-IL-1Rap-C8-H2B-B5 FAB heavy chain

<400> 47
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Gln Phe Ser Glu Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Thr Val Gly Gly Phe Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 48
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 48 - anti-IL-1Rap-C8-H2B-C10 FAB heavy chain

<400> 48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Gln Phe Ser Glu Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 49
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 49 - anti-IL-1Rap-C8-recA FAB heavy chain

<400> 49
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Thr Trp Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 50
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 50 - anti-IL-1Rap-C8-recB FAB heavy chain

<400> 50
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Arg Arg Ala Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 51
<211> 225
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 51 - anti-IL-1Rap-C8-recC FAB heavy chain

<400> 51
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys 
225 

<210> 52
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 52 - anti-IL-1Rap-UCP02-C8 IgG1 LALA heavy chain

<400> 52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Gln Phe Ser Glu Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 53
<211> 448
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 53 - anti-IL-1Rap-UCP02-C3 IgG1 LALA heavy chain

<400> 53
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             



<210> 54
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 54 - anti-IL-1Rap-C8-RecC IgG1 LALA heavy chain

<400> 54
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 55
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 55 - anti-IL-1Rap-C8-RecC-AA IgG1 LALA heavy chain

<400> 55
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Ala Ala Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 56
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 56 - anti-IL-1Rap-C8-RecC-DA IgG1 LALA heavy chain

<400> 56
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Asp Ala Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 57
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 57 - anti-IL-1Rap-C8-RecC-AS IgG1 LALA heavy chain

<400> 57
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Ala Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 58
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 58 - anti-IL-1Rap-C8-RecC-ES IgG1 LALA heavy chain

<400> 58
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Glu Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 59
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 59 - anti-IL-1Rap-C8-RecC-ET IgG1 LALA heavy chain

<400> 59
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Glu Thr Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly Lys 
    450         

<210> 60
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 60 - anti-IL-1Rap-C3-MP01-A2 FAB heavy chain

<400> 60
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Tyr 
            20                  25                  30          
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 61
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 61 - anti-IL-1Rap-C3-MP01-A3 FAB heavy chain

<400> 61
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser His Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 62
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 62 - anti-IL-1Rap-C3-MP01-B5 FAB heavy chain

<400> 62
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Thr Tyr 
            20                  25                  30          
Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 63
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 63 - anti-IL-1Rap-C3-MP01-B7 FAB heavy chain

<400> 63
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Gly Phe 
            20                  25                  30          
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 64
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 64 - anti-IL-1Rap-C3-MP01-D2 FAB heavy chain

<400> 64
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Phe 
            20                  25                  30          
Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 65
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 65 - anti-IL-1Rap-C3-MP01-F5 FAB heavy chain

<400> 65
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Leu Ser Asn Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 66
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 66 - anti-IL-1Rap-C3-MP01-G10 FAB heavy chain

<400> 66
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 67
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 67 - anti-IL-1Rap-C3-MP02-B8 FAB heavy chain

<400> 67
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu His Ser 
            20                  25                  30          
Ser Ala Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 68
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 68 - anti-IL-1Rap-C3-MP02-F6 FAB heavy chain

<400> 68
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Asp Tyr 
            20                  25                  30          
Pro Leu Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 69
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 69 - anti-IL-1Rap-C3-MP02-G2 FAB heavy chain

<400> 69
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Asp Val Ala 
            20                  25                  30          
Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 70
<211> 221
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 70 - anti-IL-1Rap-C3-UCP01-H4 FAB heavy chain

<400> 70
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 
            20                  25                  30          
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe His Tyr Arg Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220     

<210> 71
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 71 - Vk3-15/Jk1-Ck light chain

<400> 71
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 72
<211> 451
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 72 - Anti-IL-1RAP C8-RecC-ES IgG1 LALA heavy chain

<400> 72
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Ser Pro Ala Glu Pro Tyr 
            20                  25                  30          
Ala Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Gly Gln Thr Leu Tyr Glu Ser Gly Arg Gln Phe Asp Ile Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             
Ser Pro Gly 
    450     

<210> 73
<211> 447
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 73 - Anti-IL-1RAP C3-A3 mmIgG2a LALA heavy chain

<400> 73
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser His Tyr 
            20                  25                  30          
Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro 
        115                 120                 125             
Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn 
145                 150                 155                 160 
Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr 
            180                 185                 190         
Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro 
    210                 215                 220                 
Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 
Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu 
                245                 250                 255     
Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro 
            260                 265                 270         
Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala 
        275                 280                 285             
Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val 
    290                 295                 300                 
Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe 
305                 310                 315                 320 
Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr 
                325                 330                 335     
Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu 
            340                 345                 350         
Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys 
        355                 360                 365             
Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn 
    370                 375                 380                 
Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp 
385                 390                 395                 400 
Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys 
                405                 410                 415     
Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly 
            420                 425                 430         
Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
        435                 440                 445         

<210> 74
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 74 - Anti-IL-1RAP C3-A3 mmIgG2a LALA light chain

<400> 74
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             
Phe Asn Arg Asn Glu Cys 
    210                 

<210> 75
<211> 439
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 75 - ABC mmIgG1 heavy chain

<400> 75
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             
Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 
Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     
Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
            180                 185                 190         
Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    210                 215                 220                 
Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 
Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                245                 250                 255     
Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            260                 265                 270         
Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
        275                 280                 285             
Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    290                 295                 300                 
Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
305                 310                 315                 320 
Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                325                 330                 335     
Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            340                 345                 350         
Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
        355                 360                 365             
Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    370                 375                 380                 
Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 
385                 390                 395                 400 
Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                405                 410                 415     
Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
            420                 425                 430         
Ser Leu Ser His Ser Pro Gly 
        435                 

<210> 76
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 76 - ABC mmIgG light chain

<400> 76
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Asn 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         
Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             
Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 
Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 
Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         
Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             
Phe Asn Arg Asn Glu Cys 
    210                 

<210> 77
<211> 445
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 77 - ABC mmIgG2a LALA heavy chain

<400> 77
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             
Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly 
145                 150                 155                 160 
Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     
Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro 
            180                 185                 190         
Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             
Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro 
    210                 215                 220                 
Pro Cys Lys Cys Pro Ala Pro Asn Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro 
                245                 250                 255     
Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 
            260                 265                 270         
Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr 
        275                 280                 285             
Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala 
    290                 295                 300                 
Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 
305                 310                 315                 320 
Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser 
                325                 330                 335     
Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro 
            340                 345                 350         
Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val 
        355                 360                 365             
Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly 
    370                 375                 380                 
Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 
                405                 410                 415     
Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 
            420                 425                 430         
Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
        435                 440                 445 

<210> 78
<211> 446
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 78 - Human ABC IgG1 LALA heavy chain

<400> 78
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Lys Ser Tyr Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     

<210> 79
<211> 214
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 79 - Human ABC IgG light chain

<400> 79
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Asn 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210> 80
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 80 - Anakinra

<400> 80
Met Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg 
1               5                   10                  15      
Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu 
            20                  25                  30          
Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile 
        35                  40                  45              
Asp Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly 
    50                  55                  60                  
Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu 
65                  70                  75                  80  
Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln 
                85                  90                  95      
Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser 
            100                 105                 110         
Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu 
        115                 120                 125             
Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met 
    130                 135                 140                 
Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 

<210> 81
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 81 - anti-IL-1Rap-UCP02-A4 CDRH1

<400> 81
Gly Gly Val Phe Ser Tyr Tyr Ala Ile Ser 
1               5                   10  

<210> 82
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 82 - anti-IL-1Rap-UCP02-A6 CDRH1

<400> 82
Gly Gly Ala Phe Arg Ile Tyr Ala Ile His 
1               5                   10  

<210> 83
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 83 - anti-IL-1Rap-UCP02-B11 CDRH1

<400> 83
Gly Gly His Phe Ser Gln Phe Ala Ile Ser 
1               5                   10  

<210> 84
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 84 - anti-IL-1Rap-UCP02-B5 CDRH1

<400> 84
Gly Gly Tyr Phe Ser Ala Tyr Ile Ile Ser 
1               5                   10  

<210> 85
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 85 - anti-IL-1Rap-UCP02-C3 CDRH1

<400> 85
Gly Phe Thr Phe Arg Asp Tyr Ala Met Gly 
1               5                   10  

<210> 86
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 86 - anti-IL-1Rap-UCP02-C5 CDRH1

<400> 86
Gly Gly His Phe Asn Ile Tyr Ala Ile Ser 
1               5                   10  

<210> 87
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 87 - anti-IL-1Rap-UCP02-C8 CDRH1

<400> 87
Gly Gly Gln Phe Ser Glu Tyr Ala Ile Gln 
1               5                   10  

<210> 88
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 88 - anti-IL-1Rap-UCP02-C9 CDRH1

<400> 88
Gly Gly Val Phe Ser Tyr Tyr Ala Phe His 
1               5                   10  

<210> 89
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 89 - anti-IL-1Rap-UCP02-D2 CDRH1

<400> 89
Gly Gly Arg Phe Ser Asp Ser Ala Ile His 
1               5                   10  

<210> 90
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 90 - anti-IL-1Rap-UCP02-G11 CDRH1

<400> 90
Gly Gly Gln Phe Asn Asp Tyr Ala Ile His 
1               5                   10  

<210> 91
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 91 - anti-IL-1Rap-UCP02-G3 CDRH1

<400> 91
Gly Gly Tyr Leu Asn Glu Tyr Ala Ile His 
1               5                   10  

<210> 92
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 92 - anti-IL-1Rap-UCP02-G8 CDRH1

<400> 92
Gly Gly Phe Phe Ser Ile Tyr Ala Ile Ser 
1               5                   10  

<210> 93
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 93 - anti-IL-1Rap-UCP02-H8 CDRH1

<400> 93
Gly Gly Val Phe Ser Gly Tyr Ala Ile Ser 
1               5                   10  

<210> 94
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 94 - anti-IL-1Rap-UCP02-H9 CDRH1

<400> 94
Gly Gly Pro Phe Ser Ser Tyr Ala Leu Ser 
1               5                   10  

<210> 95
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 95 - anti-IL-1Rap-UCP03-A2 CDRH1

<400> 95
Gly Gly Lys Phe Asn Phe Asp Val Ile His 
1               5                   10  

<210> 96
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 96 - anti-IL-1Rap-UCP03-A3 CDRH1

<400> 96
Gly Gly Leu Phe Asn Glu Asn Ala Ile His 
1               5                   10  

<210> 97
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 97 - anti-IL-1Rap-UCP03-B4 CDRH1

<400> 97
Gly Gly Pro Phe Ser Gln His Ala Ile Ser 
1               5                   10  

<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 98 - anti-IL-1Rap-UCP03-B6 CDRH1

<400> 98
Gly Asp Pro Phe Ser Val Tyr Ile Ile His 
1               5                   10  

<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 99 - anti-IL-1Rap-UCP03-C1 CDRH1

<400> 99
Gly Gly Arg Phe Ser Ser Asn Ala Ile Ser 
1               5                   10  

<210> 100
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 100 - anti-IL-1Rap-UCP03-C2 CDRH1

<400> 100
Gly Asp Pro Phe Lys Arg Tyr Ala Ile Gly 
1               5                   10  

<210> 101
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 101 - anti-IL-1Rap-UCP03-F4 CDRH1

<400> 101
Gly Gly Gly Phe Ser Glu Tyr Ala Ile His 
1               5                   10  

<210> 102
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 102 - anti-IL-1Rap-UCP03-G3 CDRH1

<400> 102
Gly Gly Pro Leu Ser Gly Tyr Ala Phe His 
1               5                   10  

<210> 103
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 103 - anti-IL-1Rap-UCP03-G4 CDRH1

<400> 103
Gly Gly Arg Phe Ser His Tyr Val Phe Ser 
1               5                   10  

<210> 104
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 104 - anti-IL-1Rap-UCP04-C1 CDRH1

<400> 104
Gly Phe Thr Phe Ser Ala Tyr Thr Met Ser 
1               5                   10  

<210> 105
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 105 - anti-IL-1Rap-C8-H1A-C4 CDRH1

<400> 105
Gly Gly Lys Leu Asn Ala Tyr Ala Ile Gln 
1               5                   10  

<210> 106
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 106 - anti-IL-1Rap-C8-H1A-C8 CDRH1

<400> 106
Gly Gly Leu Phe Ser Asp Tyr Ala Ile Gln 
1               5                   10  

<210> 107
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 107 - anti-IL-1Rap-C8-H1A-D8 CDRH1

<400> 107
Gly Gly His Phe Asn Asn Tyr Ala Ile Gln 
1               5                   10  

<210> 108
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 108 - anti-IL-1Rap-C8-H1A-F1 CDRH1

<400> 108
Gly Gly Ile Phe Ser Asn Tyr Ala Ile Gln 
1               5                   10  

<210> 109
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 109 - anti-IL-1Rap-C8-H1A-G11 CDRH1

<400> 109
Gly Gly Arg Phe His Gln Tyr Ala Ile Gln 
1               5                   10  

<210> 110
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 110 - anti-IL-1Rap-C8-H1A-G1 CDRH1

<400> 110
Gly Gly Ala Ser Arg Ala Tyr Ala Ile His 
1               5                   10  

<210> 111
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 111 - anti-IL-1Rap-C8-H1A-G3 CDRH1

<400> 111
Gly Gly Pro Phe Ser Asp Tyr Ala Ile Gln 
1               5                   10  

<210> 112
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 112 - anti-IL-1Rap-C8-H1B-A8 CDRH1

<400> 112
Gly Glu Gly Ser Tyr Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 113
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 113 - anti-IL-1Rap-C8-H1B-B10 CDRH1

<400> 113
Gly Val Thr His Thr Ser Tyr Ala Ile Gln 
1               5                   10  

<210> 114
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 114 - anti-IL-1Rap-C8-H1B-B8 CDRH1

<400> 114
Gly Ser Pro Ala Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 115
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 115 - anti-IL-1Rap-C8-H1B-D8 CDRH1

<400> 115
Gly Pro Ser Asn Pro Val Tyr Ala Ile Gln 
1               5                   10  

<210> 116
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 116 - anti-IL-1Rap-C8-H1B-E7 CDRH1

<400> 116
Gly Ser Lys His Gly Asn Tyr Ala Ile Gln 
1               5                   10  

<210> 117
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 117 - anti-IL-1Rap-C8-H1B-F3 CDRH1

<400> 117
Gly Gly Pro His Thr Ala His Ala Ile Gln 
1               5                   10  

<210> 118
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 118 - anti-IL-1Rap-C8-H1B-G10 CDRH1

<400> 118
Gly Gly Pro Arg Arg Ala Tyr Ala Ile Gln 
1               5                   10  

<210> 119
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 119 - anti-IL-1Rap-C8-H1B-H10 CDRH1

<400> 119
Gly Ser Thr Trp Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 120
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 120 - anti-IL-1Rap-C8-H2B-B5 CDRH1

<400> 120
Gly Gly Gln Phe Ser Glu Tyr Ala Ile Gln 
1               5                   10  

<210> 121
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 121 - anti-IL-1Rap-C8-H2B-C10 CDRH1

<400> 121
Gly Gly Gln Phe Ser Glu Tyr Ala Ile Gln 
1               5                   10  

<210> 122
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 122 - anti-IL-1Rap-C8-recA CDRH1

<400> 122
Gly Ser Thr Trp Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 123
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 123 - anti-IL-1Rap-C8-recB CDRH1

<400> 123
Gly Gly Pro Arg Arg Ala Tyr Ala Ile Gln 
1               5                   10  

<210> 124
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 124 - anti-IL-1Rap-C8-recC CDRH1

<400> 124
Gly Ser Pro Ala Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 125
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 125 - anti-IL-1Rap-C8-RecC-AA CDRH1

<400> 125
Gly Ser Pro Ala Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 126
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 126 - anti-IL-1Rap-C8-RecC-DA CDRH1

<400> 126
Gly Ser Pro Ala Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 127
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 127 - anti-IL-1Rap-C8-RecC-AS CDRH1

<400> 127
Gly Ser Pro Ala Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 128
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 128 - anti-IL-1Rap-C8-RecC-ES CDRH1

<400> 128
Gly Ser Pro Ala Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 129
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 129 - anti-IL-1Rap-C8-RecC-ET CDRH1

<400> 129
Gly Ser Pro Ala Glu Pro Tyr Ala Ile Gln 
1               5                   10  

<210> 130
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 130 - anti-IL-1Rap-C3-MP01-A2 CDRH1

<400> 130
Gly Phe Thr Phe Ala Glu Tyr Ala Met Asn 
1               5                   10  

<210> 131
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 131 - anti-IL-1Rap-C3-MP01-A3 CDRH1

<400> 131
Gly Phe Ile Phe Ser His Tyr Gly Met Ser 
1               5                   10  

<210> 132
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 132 - anti-IL-1Rap-C3-MP01-B5 CDRH1

<400> 132
Gly Phe Ile Phe Ser Thr Tyr Gly Met Gly 
1               5                   10  

<210> 133
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 133 - anti-IL-1Rap-C3-MP01-B7 CDRH1

<400> 133
Gly Phe Thr Leu Ser Gly Phe Ser Met Ser 
1               5                   10  

<210> 134
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 134 - anti-IL-1Rap-C3-MP01-D2 CDRH1

<400> 134
Gly Phe Thr Phe Ser Gln Phe Gly Met Thr 
1               5                   10  

<210> 135
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 135 - anti-IL-1Rap-C3-MP01-F5 CDRH1

<400> 135
Gly Phe Pro Leu Ser Asn Tyr Gly Met Ser 
1               5                   10  

<210> 136
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 136 - anti-IL-1Rap-C3-MP01-G10 CDRH1

<400> 136
Gly Phe Thr Phe Ser His Tyr Gly Met Ser 
1               5                   10  

<210> 137
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 137 - anti-IL-1Rap-C3-MP02-B8 CDRH1

<400> 137
Gly Phe Thr Phe Glu His Ser Ser Ala Gly 
1               5                   10  

<210> 138
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 138 - anti-IL-1Rap-C3-MP02-F6 CDRH1

<400> 138
Gly Phe Thr Phe Pro Asp Tyr Pro Leu Gly 
1               5                   10  

<210> 139
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 139 - anti-IL-1Rap-C3-MP02-G2 CDRH1

<400> 139
Gly Phe Thr Tyr Asp Val Ala Pro Met Gly 
1               5                   10  

<210> 140
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 140 - anti-IL-1Rap-C3-UCP01-H4 CDRH1

<400> 140
Gly Phe Thr Phe Arg Asp Tyr Ala Met Gly 
1               5                   10  

<210> 141
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 141 - anti-IL-1Rap-UCP02-A4 CDRH2

<400> 141
Ala Ile Ile Pro Asp Phe Gly His Thr Ile 
1               5                   10  

<210> 142
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 142 - anti-IL-1Rap-UCP02-A6 CDRH2

<400> 142
Gly Ile Leu Ala Ser Gly Gly Gly Ala Val 
1               5                   10  

<210> 143
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 143 - anti-IL-1Rap-UCP02-B11 CDRH2

<400> 143
Gly Ile Ala Pro Gly Leu Gly Ser Thr Arg 
1               5                   10  

<210> 144
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 144 - anti-IL-1Rap-UCP02-B5 CDRH2

<400> 144
Gly Ile Val Pro Gln Tyr Gly Tyr Ala Thr 
1               5                   10  

<210> 145
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 145 - anti-IL-1Rap-UCP02-C3 CDRH2

<400> 145
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 146
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 146 - anti-IL-1Rap-UCP02-C5 CDRH2

<400> 146
Tyr Ile Ile Pro Ser Leu Gly Ala Val Asp 
1               5                   10  

<210> 147
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 147 - anti-IL-1Rap-UCP02-C8 CDRH2

<400> 147
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 148
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 148 - anti-IL-1Rap-UCP02-C9 CDRH2

<400> 148
Gly Ile Ile Pro Gly Tyr Gly Ala Thr Phe 
1               5                   10  

<210> 149
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 149 - anti-IL-1Rap-UCP02-D2 CDRH2

<400> 149
Tyr Ile Leu Pro Gln Phe Gly Ala Pro Leu 
1               5                   10  

<210> 150
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 150 - anti-IL-1Rap-UCP02-G11 CDRH2

<400> 150
Tyr Ile Ile Pro Ala Tyr Gly Gln Ala Glu 
1               5                   10  

<210> 151
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 151 - anti-IL-1Rap-UCP02-G3 CDRH2

<400> 151
Ala Val Ile Pro Arg Tyr Gly Gln Thr Tyr 
1               5                   10  

<210> 152
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 152 - anti-IL-1Rap-UCP02-G8 CDRH2

<400> 152
Gly Ile Ala Pro Ala Ala Gly Ile Ala Glu 
1               5                   10  

<210> 153
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 153 - anti-IL-1Rap-UCP02-H8 CDRH2

<400> 153
Gly Ile Ile Pro Glu Phe Gly Ala Thr Asn 
1               5                   10  

<210> 154
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 154 - anti-IL-1Rap-UCP02-H9 CDRH2

<400> 154
Gly Ile Ile Pro His His Gly Ala Thr Tyr 
1               5                   10  

<210> 155
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 155 - anti-IL-1Rap-UCP03-A2 CDRH2

<400> 155
Gly Ile Ile Pro Asp Phe Ala Ser Thr His 
1               5                   10  

<210> 156
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 156 - anti-IL-1Rap-UCP03-A3 CDRH2

<400> 156
Gly Ile Ile Pro Asp Val Gly Ala Ala Phe 
1               5                   10  

<210> 157
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 157 - anti-IL-1Rap-UCP03-B4 CDRH2

<400> 157
Gly Ile Ile Pro Phe Glu Gly Val Ala Phe 
1               5                   10  

<210> 158
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 158 - anti-IL-1Rap-UCP03-B6 CDRH2

<400> 158
Tyr Ile Ile Ala Gln Gln Gly Ser Ala Ser 
1               5                   10  

<210> 159
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 159 - anti-IL-1Rap-UCP03-C1 CDRH2

<400> 159
Gly Ile Ile Pro His Phe Gly Ala Val Tyr 
1               5                   10  

<210> 160
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 160 - anti-IL-1Rap-UCP03-C2 CDRH2

<400> 160
Gly Ile Ile Pro Thr Thr Gly Glu Ala Ile 
1               5                   10  

<210> 161
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 161 - anti-IL-1Rap-UCP03-F4 CDRH2

<400> 161
Ala Ile Leu Pro Glu Gln Gly Ala Ala Tyr 
1               5                   10  

<210> 162
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 162 - anti-IL-1Rap-UCP03-G3 CDRH2

<400> 162
Gly Ile Ile Pro Asn Phe Ala Gln Thr Asp 
1               5                   10  

<210> 163
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 163 - anti-IL-1Rap-UCP03-G4 CDRH2

<400> 163
Gly Ile Ile Pro Tyr Glu Gly Lys Pro Phe 
1               5                   10  

<210> 164
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 164 - anti-IL-1Rap-UCP04-C1 CDRH2

<400> 164
Ala Ile Ser Tyr Glu Gly Asp Gly Thr Leu 
1               5                   10  

<210> 165
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 165 - anti-IL-1Rap-C8-H1A-C4 CDRH2

<400> 165
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 166
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 166 - anti-IL-1Rap-C8-H1A-C8 CDRH2

<400> 166
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 167
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 167 - anti-IL-1Rap-C8-H1A-D8 CDRH2

<400> 167
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 168
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 168 - anti-IL-1Rap-C8-H1A-F1 CDRH2

<400> 168
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 169
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 169 - anti-IL-1Rap-C8-H1A-G11 CDRH2

<400> 169
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 170
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 170 - anti-IL-1Rap-C8-H1A-G1 CDRH2

<400> 170
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 171
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 171 - anti-IL-1Rap-C8-H1A-G3 CDRH2

<400> 171
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 172
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 172 - anti-IL-1Rap-C8-H1B-A8 CDRH2

<400> 172
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 173
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 173 - anti-IL-1Rap-C8-H1B-B10 CDRH2

<400> 173
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 174
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 174 - anti-IL-1Rap-C8-H1B-B8 CDRH2

<400> 174
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 175
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 175 - anti-IL-1Rap-C8-H1B-D8 CDRH2

<400> 175
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 176
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 176 - anti-IL-1Rap-C8-H1B-E7 CDRH2

<400> 176
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 177
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 177 - anti-IL-1Rap-C8-H1B-F3 CDRH2

<400> 177
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 178
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 178 - anti-IL-1Rap-C8-H1B-G10 CDRH2

<400> 178
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 179
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 179 - anti-IL-1Rap-C8-H1B-H10 CDRH2

<400> 179
Tyr Ile Ile Pro Leu His Gly Gln Val Asp 
1               5                   10  

<210> 180
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 180 - anti-IL-1Rap-C8-H2B-B5 CDRH2

<400> 180
Tyr Ile Ile Pro Thr Val Gly Gly Phe Asp 
1               5                   10  

<210> 181
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 181 - anti-IL-1Rap-C8-H2B-C10 CDRH2

<400> 181
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 182
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 182 - anti-IL-1Rap-C8-recA CDRH2

<400> 182
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 183
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 183 - anti-IL-1Rap-C8-recB CDRH2

<400> 183
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 184
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 184 - anti-IL-1Rap-C8-recC CDRH2

<400> 184
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 185
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 185 - anti-IL-1Rap-C8-RecC-AA CDRH2

<400> 185
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 186
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 186 - anti-IL-1Rap-C8-RecC-DA CDRH2

<400> 186
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 187
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 187 - anti-IL-1Rap-C8-RecC-AS CDRH2

<400> 187
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 188
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 188 - anti-IL-1Rap-C8-RecC-ES CDRH2

<400> 188
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 189
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 189 - anti-IL-1Rap-C8-RecC-ET CDRH2

<400> 189
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp 
1               5                   10  

<210> 190
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 190 - anti-IL-1Rap-C3-MP01-A2 CDRH2

<400> 190
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 191
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 191 - anti-IL-1Rap-C3-MP01-A3 CDRH2

<400> 191
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 192
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 192 - anti-IL-1Rap-C3-MP01-B5 CDRH2

<400> 192
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 193
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 193 - anti-IL-1Rap-C3-MP01-B7 CDRH2

<400> 193
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 194
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 194 - anti-IL-1Rap-C3-MP01-D2 CDRH2

<400> 194
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 195
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 195 - anti-IL-1Rap-C3-MP01-F5 CDRH2

<400> 195
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 196
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 196 - anti-IL-1Rap-C3-MP01-G10 CDRH2

<400> 196
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 197
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 197 - anti-IL-1Rap-C3-MP02-B8 CDRH2

<400> 197
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 198
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 198 - anti-IL-1Rap-C3-MP02-F6 CDRH2

<400> 198
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 199
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 199 - anti-IL-1Rap-C3-MP02-G2 CDRH2

<400> 199
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 200
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 200 - anti-IL-1Rap-C3-UCP01-H4 CDRH2

<400> 200
Ala Ile Ser Tyr Asp Gly Glu Gly Thr Leu 
1               5                   10  

<210> 201
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 201 - anti-IL-1Rap-UCP02-A4 CDRH3

<400> 201
Ala Arg Ala Ser Pro Tyr Lys Gly Trp Trp Asp Tyr 
1               5                   10          

<210> 202
<211> 14
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 202 - anti-IL-1Rap-UCP02-A6 CDRH3

<400> 202
Ala Arg Ala Lys Asp Ile Tyr Gly Tyr Gly Tyr Gly Asp Ile 
1               5                   10                  

<210> 203
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 203 - anti-IL-1Rap-UCP02-B11 CDRH3

<400> 203
Ala Arg Asp Ser Ile Tyr Ser Ala Trp Leu Ala Tyr 
1               5                   10          

<210> 204
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 204 - anti-IL-1Rap-UCP02-B5 CDRH3

<400> 204
Ala Arg Gly Arg Ser Thr Thr Tyr Tyr Gly Phe Ala Tyr 
1               5                   10              

<210> 205
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 205 - anti-IL-1Rap-UCP02-C3 CDRH3

<400> 205
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 206
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 206 - anti-IL-1Rap-UCP02-C5 CDRH3

<400> 206
Ala Arg Ala Ser Ile Tyr His Gly Trp Met Ala Tyr 
1               5                   10          

<210> 207
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 207 - anti-IL-1Rap-UCP02-C8 CDRH3

<400> 207
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 208
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 208 - anti-IL-1Rap-UCP02-C9 CDRH3

<400> 208
Ala Arg Pro Val Ser Tyr Ser Ser Gly Trp Tyr Asp Tyr 
1               5                   10              

<210> 209
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 209 - anti-IL-1Rap-UCP02-D2 CDRH3

<400> 209
Ala Arg Gly Ser Tyr Tyr Gly Val Val Gly Tyr Val Pro Asp Asp Tyr 
1               5                   10                  15      



<210> 210
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 210 - anti-IL-1Rap-UCP02-G11 CDRH3

<400> 210
Ala Arg Val Pro Tyr Ser Thr Ala Tyr Phe Asp Tyr 
1               5                   10          

<210> 211
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 211 - anti-IL-1Rap-UCP02-G3 CDRH3

<400> 211
Ala Arg Pro Leu Gly Tyr Ser Tyr Gly Trp Phe Asp Tyr 
1               5                   10              

<210> 212
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 212 - anti-IL-1Rap-UCP02-G8 CDRH3

<400> 212
Ala Arg Gly Gln Ser Pro Gly Arg Val Arg Glu Glu Tyr Trp Tyr Asp 
1               5                   10                  15      
Tyr 
    

<210> 213
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 213 - anti-IL-1Rap-UCP02-H8 CDRH3

<400> 213
Ala Arg His Ser Ser Ala Tyr Ser Pro Trp Phe Asp Tyr 
1               5                   10              

<210> 214
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 214 - anti-IL-1Rap-UCP02-H9 CDRH3

<400> 214
Ala Arg His Pro Asp Val Tyr Thr Pro Trp Phe Asp Val 
1               5                   10              

<210> 215
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 215 - anti-IL-1Rap-UCP03-A2 CDRH3

<400> 215
Ala Arg Val Pro Asp Tyr Tyr Thr Gly Trp Met Ala Tyr 
1               5                   10              

<210> 216
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 216 - anti-IL-1Rap-UCP03-A3 CDRH3

<400> 216
Ala Arg Gly Ser Ile Tyr Thr Ala Trp Phe Ala Val 
1               5                   10          

<210> 217
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 217 - anti-IL-1Rap-UCP03-B4 CDRH3

<400> 217
Ala Arg Ser Ser Ser Tyr Tyr Ser Trp Leu Asp Tyr 
1               5                   10          

<210> 218
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 218 - anti-IL-1Rap-UCP03-B6 CDRH3

<400> 218
Ala Arg Val Pro Asp Pro Tyr Ser Gly His Phe Asp Tyr 
1               5                   10              

<210> 219
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 219 - anti-IL-1Rap-UCP03-C1 CDRH3

<400> 219
Ala Arg Gly Ser Val Tyr Thr Gly Trp Phe Asp Asn 
1               5                   10          

<210> 220
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 220 - anti-IL-1Rap-UCP03-C2 CDRH3

<400> 220
Ala Arg His Gly Thr Thr Tyr Ala Ala Phe Asp His 
1               5                   10          

<210> 221
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 221 - anti-IL-1Rap-UCP03-F4 CDRH3

<400> 221
Ala Arg Val Gly Leu Tyr Val Pro Tyr Met Asp Ile 
1               5                   10          

<210> 222
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 222 - anti-IL-1Rap-UCP03-G3 CDRH3

<400> 222
Ala Arg Phe Ser Ile Tyr Ser Gly Trp Ser Asp Val 
1               5                   10          

<210> 223
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 223 - anti-IL-1Rap-UCP03-G4 CDRH3

<400> 223
Ala Arg Ser Asp Tyr Phe Tyr Tyr Tyr Phe Asp Pro 
1               5                   10          

<210> 224
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 224 - anti-IL-1Rap-UCP04-C1 CDRH3

<400> 224
Ala Arg Ser Leu Tyr Trp Ser Gly Phe Asp Tyr 
1               5                   10      

<210> 225
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 225 - anti-IL-1Rap-C8-H1A-C4 CDRH3

<400> 225
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 226
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 226 - anti-IL-1Rap-C8-H1A-C8 CDRH3

<400> 226
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 227
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 227 - anti-IL-1Rap-C8-H1A-D8 CDRH3

<400> 227
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 228
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 228 - anti-IL-1Rap-C8-H1A-F1 CDRH3

<400> 228
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 229
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 229 - anti-IL-1Rap-C8-H1A-G11 CDRH3

<400> 229
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 230
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 230 - anti-IL-1Rap-C8-H1A-G1 CDRH3

<400> 230
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 231
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 231 - anti-IL-1Rap-C8-H1A-G3 CDRH3

<400> 231
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 232
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 232 - anti-IL-1Rap-C8-H1B-A8 CDRH3

<400> 232
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 233
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 233 - anti-IL-1Rap-C8-H1B-B10 CDRH3

<400> 233
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 234
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 234 - anti-IL-1Rap-C8-H1B-B8 CDRH3

<400> 234
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 235
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 235 - anti-IL-1Rap-C8-H1B-D8 CDRH3

<400> 235
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 236
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 236 - anti-IL-1Rap-C8-H1B-E7 CDRH3

<400> 236
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 237
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 237 - anti-IL-1Rap-C8-H1B-F3 CDRH3

<400> 237
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 238
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 238 - anti-IL-1Rap-C8-H1B-G10 CDRH3

<400> 238
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 239
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 239 - anti-IL-1Rap-C8-H1B-H10 CDRH3

<400> 239
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 240
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 240 - anti-IL-1Rap-C8-H2B-B5 CDRH3

<400> 240
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 241
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 241 - anti-IL-1Rap-C8-H2B-C10 CDRH3

<400> 241
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 242
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 242 - anti-IL-1Rap-C8-recA CDRH3

<400> 242
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 243
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 243 - anti-IL-1Rap-C8-recB CDRH3

<400> 243
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 244
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 244 - anti-IL-1Rap-C8-recC CDRH3

<400> 244
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 245
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 245 - anti-IL-1Rap-C8-RecC-AA CDRH3

<400> 245
Ala Arg Gly Gln Thr Leu Tyr Ala Ala Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 246
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 246 - anti-IL-1Rap-C8-RecC-DA CDRH3

<400> 246
Ala Arg Gly Gln Thr Leu Tyr Asp Ala Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 247
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 247 - anti-IL-1Rap-C8-RecC-AS CDRH3

<400> 247
Ala Arg Gly Gln Thr Leu Tyr Ala Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 248
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 248 - anti-IL-1Rap-C8-RecC-ES CDRH3

<400> 248
Ala Arg Gly Gln Thr Leu Tyr Glu Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 249
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 249 - anti-IL-1Rap-C8-RecC-ET CDRH3

<400> 249
Ala Arg Gly Gln Thr Leu Tyr Glu Thr Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 250
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 250 - anti-IL-1Rap-C3-MP01-A2 CDRH3

<400> 250
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 251
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 251 - anti-IL-1Rap-C3-MP01-A3 CDRH3

<400> 251
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 252
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 252 - anti-IL-1Rap-C3-MP01-B5 CDRH3

<400> 252
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 253
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 253 - anti-IL-1Rap-C3-MP01-B7 CDRH3

<400> 253
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 254
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 254 - anti-IL-1Rap-C3-MP01-D2 CDRH3

<400> 254
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 255
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 255 - anti-IL-1Rap-C3-MP01-F5 CDRH3

<400> 255
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 256
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 256 - anti-IL-1Rap-C3-MP01-G10 CDRH3

<400> 256
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 257
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 257 - anti-IL-1Rap-C3-MP02-B8 CDRH3

<400> 257
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 258
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 258 - anti-IL-1Rap-C3-MP02-F6 CDRH3

<400> 258
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 259
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 259 - anti-IL-1Rap-C3-MP02-G2 CDRH3

<400> 259
Ala Arg Phe Arg Tyr Tyr Thr Ala Phe Asp Tyr 
1               5                   10      

<210> 260
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> >SEQ ID NO: 260 - anti-IL-1Rap-C3-UCP01-H4 CDRH3

<400> 260
Ala Arg Phe His Tyr Arg Ser Ala Phe Asp Tyr 
1               5                   10      

<210> 261
<211> 360
<212> PRT
<213> Mus musculus


<220> 
<223> >SEQ ID NO: 261 - mus musculus IL-1RAP

<400> 261
Met Gly Leu Leu Trp Tyr Leu Met Ser Leu Ser Phe Tyr Gly Ile Leu 
1               5                   10                  15      
Gln Ser His Ala Ser Glu Arg Cys Asp Asp Trp Gly Leu Asp Thr Met 
            20                  25                  30          
Arg Gln Ile Gln Val Phe Glu Asp Glu Pro Ala Arg Ile Lys Cys Pro 
        35                  40                  45              
Leu Phe Glu His Phe Leu Lys Tyr Asn Tyr Ser Thr Ala His Ser Ser 
    50                  55                  60                  
Gly Leu Thr Leu Ile Trp Tyr Trp Thr Arg Gln Asp Arg Asp Leu Glu 
65                  70                  75                  80  
Glu Pro Ile Asn Phe Arg Leu Pro Glu Asn Arg Ile Ser Lys Glu Lys 
                85                  90                  95      
Asp Val Leu Trp Phe Arg Pro Thr Leu Leu Asn Asp Thr Gly Asn Tyr 
            100                 105                 110         
Thr Cys Met Leu Arg Asn Thr Thr Tyr Cys Ser Lys Val Ala Phe Pro 
        115                 120                 125             
Leu Glu Val Val Gln Lys Asp Ser Cys Phe Asn Ser Ala Met Arg Phe 
    130                 135                 140                 
Pro Val His Lys Met Tyr Ile Glu His Gly Ile His Lys Ile Thr Cys 
145                 150                 155                 160 
Pro Asn Val Asp Gly Tyr Phe Pro Ser Ser Val Lys Pro Ser Val Thr 
                165                 170                 175     
Trp Tyr Lys Gly Cys Thr Glu Ile Val Asp Phe His Asn Val Leu Pro 
            180                 185                 190         
Glu Gly Met Asn Leu Ser Phe Phe Ile Pro Leu Val Ser Asn Asn Gly 
        195                 200                 205             
Asn Tyr Thr Cys Val Val Thr Tyr Pro Glu Asn Gly Arg Leu Phe His 
    210                 215                 220                 
Leu Thr Arg Thr Val Thr Val Lys Val Val Gly Ser Pro Lys Asp Ala 
225                 230                 235                 240 
Leu Pro Pro Gln Ile Tyr Ser Pro Asn Asp Arg Val Val Tyr Glu Lys 
                245                 250                 255     
Glu Pro Gly Glu Glu Leu Val Ile Pro Cys Lys Val Tyr Phe Ser Phe 
            260                 265                 270         
Ile Met Asp Ser His Asn Glu Val Trp Trp Thr Ile Asp Gly Lys Lys 
        275                 280                 285             
Pro Asp Asp Val Thr Val Asp Ile Thr Ile Asn Glu Ser Val Ser Tyr 
    290                 295                 300                 
Ser Ser Thr Glu Asp Glu Thr Arg Thr Gln Ile Leu Ser Ile Lys Lys 
305                 310                 315                 320 
Val Thr Pro Glu Asp Leu Arg Arg Asn Tyr Val Cys His Ala Arg Asn 
                325                 330                 335     
Thr Lys Gly Glu Ala Glu Gln Ala Ala Lys Val Lys Gln Lys Gly Asn 
            340                 345                 350         
Gly Cys Thr Glu Pro Met Thr Leu 
        355                 360 

<210> 262
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> > SEQ ID NO: 262 - aanti-human IL-1RAP_candidate_1 CDRH1

<220> 
<221> VARIANT
<222> 2,3,4,5,6,7,10
<223> X at position 2 can be anyone of amino acids V, G, S, P, E. X at 
      position 3 can be anyone of I, L, A, G, T, S, P, H, K, R. X at po
      sition 4 can be anyone of L, F, A, S, W, H, N, R. X at position 5
       can be anyone of G, T, S, Y, P, H, E, N, R. X at position 6 can

<220> 
<221> VARIANT
<222> 6,7,10
<223> X at position 6 be anyone of amino acids V, A, S, P, Q, N, D. X
      at position 7 be anyone of amino acids Y, H. X at position 10 be
      anyone of amino acids H, Q.

<400> 262
Gly Xaa Xaa Xaa Xaa Xaa Xaa Ala Ile Xaa 
1               5                   10  

<210> 263
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> > SEQ ID NO: 263 - aanti-human IL-1RAP_candidate_1 CDRH2

<220> 
<221> VARIANT
<222> 5,6,8,9
<223> X at position 5 can be anyone of amino acids T, S. X at position
      6 can be anyone of amino acids V, L. X at position 9 can be
      anyone of amino acids F, Y.
      X at position 8 can be anyone of residues Q, G.

<400> 263
Tyr Ile Ile Pro Xaa Xaa Gly Xaa Xaa Asp 
1               5                   10  

<210> 264
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> > SEQ ID NO: 264 - aanti-human IL-1RAP_candidate_1 CDRH3

<220> 
<221> VARIANT
<222> 8,9

<220> 
<221> VARIANT
<222> 8,9
<223> X at position 8 can be anyone of amino acids A,E,D. X at position
      9 can be anyone of amino acids A, T, S.

<400> 264
Ala Arg Gly Gln Thr Leu Tyr Xaa Xaa Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 265
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> > SEQ ID NO: 265 - anti-mouse IL-1RAP_candidate_1 CDRH1

<220> 
<221> VARIANT
<222> 3,4,5,6,7,8,9,10
<223> X at position 3 can be anyone of amino acids I, T, P. X at positi
      on 4 can be anyone of amino acids L,F,Y. X at position 5 can be a
      nyone of amino acids A,S,P,E,D.X at position 6 can be anyone of a
      mino acids V,G,T,H,Q,E,N,D.X at position 7 can be anyone of amino

<220> 
<221> VARIANT
<222> 7,8,9,10
<223> X at position 7 can be anyone of amino acids F, A, S, Y. X at
      position 8 can be anyone of amino acids A,G, S, P. X at position
      9 can be anyone of amino acids L, M, A. X at position 10 can be
      anyone of amino acids G, T, S, N.

<400> 265
Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10  

<210> 266
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> > SEQ ID NO: 266 - anti-mouse IL-1RAP_candidate_1 CDRH1

<400> 266
Ile Val Leu Phe Cys Met Ala Gly Thr Ser Trp Tyr Pro His Gln Glu 
1               5                   10                  15      
Asn Asp Lys Arg 
            20  

<210> 267
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> > SEQ ID NO: 267 - anti-mouse IL-1RAP_candidate_1 CDRH3

<220> 
<221> VARIANT
<222> 4,6,7
<223> at position 4 can be anyone of amino acids R,H. X at position 6
      can be anyone of amino acids Y, R. X at position 7 can be anyone
      of amino acids T, S.

<400> 267
Ala Arg Phe Xaa Tyr Xaa Xaa Ala Phe Asp Tyr 
1               5                   10      

<210> 268
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> > SEQ ID NO: 268 - anti-IL-1RAP_Light chain variable sequence

<400> 268
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro Trp 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         

<210> 269
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH1_Kabat (31-35)

<400> 269
Glu Tyr Ala Ile Gln 
1               5   

<210> 270
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH1_Chothia (26-31)

<400> 270
Gly Gly Gln Phe Ser Glu 
1               5       

<210> 271
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH1_IMGT (27-38)

<400> 271
Gly Gly Gln Phe Ser Glu Tyr Ala 
1               5               

<210> 272
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH2_Kabat (50-65)

<400> 272
Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 273
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH2_Chothia (52-56)

<400> 273
Ile Pro Leu His Gly Gln 
1               5       

<210> 274
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH2_IMGT (56-65)

<400> 274
Ile Ile Pro Leu His Gly Gln Val 
1               5               

<210> 275
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH3_Kabat (95-102)

<400> 275
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 276
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH3_Chothia (95-102)

<400> 276
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 277
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8_CDRH3_IMGT (105-117)

<400> 277
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 278
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH1_Kabat (31-35)

<400> 278
Glu Pro Tyr Ala Ile Gln 
1               5       

<210> 279
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH1_Chothia (26-31)

<400> 279
Gly Ser Pro Ala Glu Pro 
1               5       

<210> 280
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH1_IMGT (27-38)

<400> 280
Gly Ser Pro Ala Glu Pro Tyr Ala 
1               5               

<210> 281
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH2_Kabat (50-65)

<400> 281
Tyr Ile Ile Pro Leu His Gly Gln Val Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 282
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH2_Chothia (52-56)

<400> 282
Ile Pro Leu His Gly Gln 
1               5       

<210> 283
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH2_IMGT (56-65)

<400> 283
Ile Ile Pro Leu His Gly Gln Val 
1               5               

<210> 284
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH3_Kabat (95-102)

<400> 284
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 285
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH3_Chothia (95-102)

<400> 285
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 286
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H1B-B8 _CDRH3_IMGT (105-117)

<400> 286
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 287
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH1_Kabat (31-35)

<400> 287
Glu Tyr Ala Ile Gln 
1               5   

<210> 288
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH1_Chothia (26-31)

<400> 288
Gly Gly Gln Phe Ser Glu 
1               5       

<210> 289
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH1_IMGT (27-38)

<400> 289
Gly Gly Gln Phe Ser Glu Tyr Ala 
1               5               

<210> 290
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH2_Kabat (50-65)

<400> 290
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 291
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH2_Chothia (52-56)

<400> 291
Ile Pro Ser Leu Gly Gly 
1               5       

<210> 292
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH2_IMGT (56-65)

<400> 292
Ile Ile Pro Ser Leu Gly Gly Tyr 
1               5               

<210> 293
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH3_Kabat (95-102)

<400> 293
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 294
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH3_Chothia (95-102)

<400> 294
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 295
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-H2B-C10 _CDRH3_IMGT (105-117)

<400> 295
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 296
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC _CDRH1_Kabat (31-35)

<400> 296
Glu Pro Tyr Ala Ile Gln 
1               5       

<210> 297
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC _CDRH1_Chothia (26-31)

<400> 297
Gly Ser Pro Ala Glu Pro 
1               5       

<210> 298
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC _CDRH1_IMGT (27-38)

<400> 298
Gly Ser Pro Ala Glu Pro Tyr Ala 
1               5               

<210> 299
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC _CDRH2_Kabat (50-65)

<400> 299
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 300
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC _CDRH2_Chothia (52-56)

<400> 300
Ile Pro Ser Leu Gly Gly 
1               5       

<210> 301
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC _CDRH2_IMGT (56-65)

<400> 301
Ile Ile Pro Ser Leu Gly Gly Tyr 
1               5               

<210> 302
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC_CDRH3_Kabat (95-102)

<400> 302
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 303
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC_CDRH3_Chothia (95-102)

<400> 303
Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 304
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC_CDRH3_IMGT (105-117)

<400> 304
Ala Arg Gly Gln Thr Leu Tyr Asp Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 305
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA _CDRH1_Kabat (31-35)

<400> 305
Glu Pro Tyr Ala Ile Gln 
1               5       

<210> 306
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA _CDRH1_Chothia (26-31)

<400> 306
Gly Ser Pro Ala Glu Pro 
1               5       

<210> 307
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA _CDRH1_IMGT (27-38)

<400> 307
Gly Ser Pro Ala Glu Pro Tyr Ala 
1               5               

<210> 308
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA _CDRH2_Kabat (50-65)

<400> 308
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 309
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA _CDRH2_Chothia (52-56)

<400> 309
Ile Pro Ser Leu Gly Gly 
1               5       

<210> 310
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA _CDRH2_IMGT (56-65)

<400> 310
Ile Ile Pro Ser Leu Gly Gly Tyr 
1               5               

<210> 311
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA_CDRH3_Kabat (95-102)

<400> 311
Gly Gln Thr Leu Tyr Ala Ala Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 312
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA_CDRH3_Chothia (95-102)

<400> 312
Gly Gln Thr Leu Tyr Ala Ala Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 313
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AA_CDRH3_IMGT (105-117)

<400> 313
Ala Arg Gly Gln Thr Leu Tyr Ala Ala Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 314
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA _CDRH1_Kabat (31-35)

<400> 314
Glu Pro Tyr Ala Ile Gln 
1               5       

<210> 315
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA _CDRH1_Chothia (26-31)

<400> 315
Gly Ser Pro Ala Glu Pro 
1               5       

<210> 316
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA _CDRH1_IMGT (27-38)

<400> 316
Gly Ser Pro Ala Glu Pro Tyr Ala 
1               5               

<210> 317
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA _CDRH2_Kabat (50-65)

<400> 317
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 318
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA _CDRH2_Chothia (52-56)

<400> 318
Ile Pro Ser Leu Gly Gly 
1               5       

<210> 319
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA _CDRH2_IMGT (56-65)

<400> 319
Ile Ile Pro Ser Leu Gly Gly Tyr 
1               5               

<210> 320
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA_CDRH3_Kabat (95-102)

<400> 320
Gly Gln Thr Leu Tyr Asp Ala Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 321
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA_CDRH3_Chothia (95-102)

<400> 321
Gly Gln Thr Leu Tyr Asp Ala Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 322
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-DA_CDRH3_IMGT (105-117)

<400> 322
Ala Arg Gly Gln Thr Leu Tyr Asp Ala Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 323
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS _CDRH1_Kabat (31-35)

<400> 323
Glu Pro Tyr Ala Ile Gln 
1               5       

<210> 324
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS _CDRH1_Chothia (26-31)

<400> 324
Gly Ser Pro Ala Glu Pro 
1               5       

<210> 325
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS _CDRH1_IMGT (27-38)

<400> 325
Gly Ser Pro Ala Glu Pro Tyr Ala 
1               5               

<210> 326
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS _CDRH2_Kabat (50-65)

<400> 326
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 327
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS _CDRH2_Chothia (52-56)

<400> 327
Ile Pro Ser Leu Gly Gly 
1               5       

<210> 328
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS _CDRH2_IMGT (56-65)

<400> 328
Ile Ile Pro Ser Leu Gly Gly Tyr 
1               5               

<210> 329
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS_CDRH3_Kabat (95-102)

<400> 329
Gly Gln Thr Leu Tyr Ala Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 330
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS_CDRH3_Chothia (95-102)

<400> 330
Gly Gln Thr Leu Tyr Ala Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 331
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-AS_CDRH3_IMGT (105-117)

<400> 331
Ala Arg Gly Gln Thr Leu Tyr Ala Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 332
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES _CDRH1_Kabat (31-35)

<400> 332
Glu Pro Tyr Ala Ile Gln 
1               5       

<210> 333
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES _CDRH1_Chothia (26-31)

<400> 333
Gly Ser Pro Ala Glu Pro 
1               5       

<210> 334
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES _CDRH1_IMGT (27-38)

<400> 334
Gly Ser Pro Ala Glu Pro Tyr Ala 
1               5               

<210> 335
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES _CDRH2_Kabat (50-65)

<400> 335
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 336
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES _CDRH2_Chothia (52-56)

<400> 336
Ile Pro Ser Leu Gly Gly 
1               5       

<210> 337
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES _CDRH2_IMGT (56-65)

<400> 337
Ile Ile Pro Ser Leu Gly Gly Tyr 
1               5               

<210> 338
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES_CDRH3_Kabat (95-102)

<400> 338
Gly Gln Thr Leu Tyr Glu Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 339
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES_CDRH3_Chothia (95-102)

<400> 339
Gly Gln Thr Leu Tyr Glu Ser Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 340
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ES_CDRH3_IMGT (105-117)

<400> 340
Ala Arg Gly Gln Thr Leu Tyr Glu Ser Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

<210> 341
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET _CDRH1_Kabat (31-35)

<400> 341
Glu Pro Tyr Ala Ile Gln 
1               5       

<210> 342
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET _CDRH1_Chothia (26-31)

<400> 342
Gly Ser Pro Ala Glu Pro 
1               5       

<210> 343
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET _CDRH1_IMGT (27-38)

<400> 343
Gly Ser Pro Ala Glu Pro Tyr Ala 
1               5               

<210> 344
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET _CDRH2_Kabat (50-65)

<400> 344
Tyr Ile Ile Pro Ser Leu Gly Gly Tyr Asp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      
Gly 
    

<210> 345
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET _CDRH2_Chothia (52-56)

<400> 345
Ile Pro Ser Leu Gly Gly 
1               5       

<210> 346
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET _CDRH2_IMGT (56-65)

<400> 346
Ile Ile Pro Ser Leu Gly Gly Tyr 
1               5               

<210> 347
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET_CDRH3_Kabat (95-102)

<400> 347
Gly Gln Thr Leu Tyr Glu Thr Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 348
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET_CDRH3_Chothia (95-102)

<400> 348
Gly Gln Thr Leu Tyr Glu Thr Gly Arg Gln Phe Asp Ile 
1               5                   10              

<210> 349
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> ISB 880-C8-recC-ET_CDRH3_IMGT (105-117)

<400> 349
Ala Arg Gly Gln Thr Leu Tyr Glu Thr Gly Arg Gln Phe Asp Ile 
1               5                   10                  15  

