                         SEQUENCE LISTING

<110>  THE ROSALIND FRANKLIN INSTITUTE
       OXFORD UNIVERSITY INNOVATION LIMITED
       THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF 
       OXFORD
 
<120>  SINGLE DOMAIN ANTIBODIES

<130>  1419-10002WO

<150>  GB2014451.5
<151>  2020-09-14

<150>  GB2108319.1
<151>  2021-06-10

<150>  GB2014453.1
<151>  2020-09-14

<160>  248   

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B12 CDR1

<400>  1

Gly Gly Thr Phe Ser Thr Tyr 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B12 CDR2

<400>  2

Ile Arg Arg Ser Gly Ser Thr 
1               5           


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B12 CDR3

<400>  3

Ala Ala Arg Arg Ala Gly Arg Glu Tyr Glu Tyr 
1               5                   10      


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2 CDR1

<400>  4

Gly Arg Thr Phe His Ser Tyr Val 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2 CDR2

<400>  5

Ile Ser Trp Ser Ser Thr Pro Thr 
1               5               


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2 CDR3

<400>  6

Ala Ala Asp Arg Gly Glu Ser Tyr Tyr Tyr Thr Arg Pro Thr Glu Tyr 
1               5                   10                  15      


Glu Phe 
        


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 CDR1

<400>  7

Gly Phe Thr Asn Asp Phe Tyr Ser 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 CDR2

<400>  8

Leu Ser Val Ser Asp Asn Thr Pro 
1               5               


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 CDR3

<400>  9

Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5 CDR1

<400>  10

Gly Val Thr Leu Gly Arg His Ala 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5 CDR2

<400>  11

Ile Arg Thr Phe Asp Gly Ile Thr 
1               5               


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5 CDR3

<400>  12

Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe 
1               5                   10                  


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 CDR1

<400>  13

Gly Arg Thr Phe Ser Thr Tyr Ser 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 CDR2

<400>  14

Met Arg Trp Thr Gly Ser Ser Thr 
1               5               


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3 CDR3

<400>  15

Ala Ile Thr Thr Ile Val Arg Ala Tyr Tyr Thr Glu Tyr Thr Glu Ala 
1               5                   10                  15      


Asp Phe Gly Ser 
            20  


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B12

<400>  16

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Phe Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ile Val 
        35                  40                  45              


Ala Ala Ile Arg Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Leu Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Arg Arg Ala Gly Arg Glu Tyr Glu Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  17
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ile Ala Ser Gly Arg Thr Phe His Ser Tyr 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Ser Thr Pro Thr Tyr Tyr Gly Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Glu Ser Tyr Tyr Tyr Thr Arg Pro Thr Glu Tyr 
            100                 105                 110         


Glu Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  18
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp Phe Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Asn Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  19
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5

<400>  19

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  20
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H3

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Met Arg Trp Thr Gly Ser Ser Thr Phe Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asn Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Thr Thr Ile Val Arg Ala Tyr Tyr Thr Glu Tyr Thr Glu Ala 
            100                 105                 110         


Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  21
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B12

<400>  21
caggtgcagc tggtggagtc tggaggaggc ttcgtgcagc ctgggggctc tctgagactc       60

tcctgcgccg tttctggagg caccttcagt acctatggca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagat tgtagcagcg attagacgga gtggtagcac atactatgca      180

gactccgtga ggggccgatt caccatctcc agagacaacg ccaagaactc ggtgctcctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtttatt actgtgcagc caggagagcg      300

ggtagggagt atgagtactg gggccagggg acccaggtca ccgtctcctc a               351


<210>  22
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F2

<400>  22
caggtgcagc tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctaagactc       60

gcttgtatag cctctggacg caccttccat agctatgtca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attagttgga gtagtacacc gacatactat      180

ggagaatccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga accgcctgaa acctgaggac acggccgttt atttctgtgc agcagaccgg      300

ggtgaaagtt actactacac tcgacccacc gagtatgaat tctggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  23
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1

<400>  23
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc       60

tcctgtgcag cctctggatt cactaatgat ttttatagca tcgcgtggtt ccgccaggcc      120

ccaggaaagg agcgtgaggg ggtctcatgg cttagtgtca gtgataatac cccaacctac      180

gtagactccg tgaaggaccg gttcaccatc tccagacaca acgccaacaa caccgtgtac      240

ctgcaaatga acatgctgaa acctgaggac acggccattt actattgtgc agcaggacgc      300

ttcgcgggaa gggatacttg gccctcgtcc tatgattact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  24
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5

<400>  24
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggggggtc tctgacactc       60

tcctgtgtcg cctctggagt cactttggga cgtcatgcca taggctggtt ccgccaggcc      120

cccgggaagg agcgtgagag agtctcgtgt attagaacat ttgatggcat cacaagttat      180

gtagagtcca cgaagggccg attcaccatc tccagtaaca atgccatgaa cacggtgtat      240

ctgcaaatga atagcctcaa acctgaagac acggccgttt atttctgtgc actgggagtg      300

actgcagcct gttcagataa tccctacttc tggggccagg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  25
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H3

<400>  25
caggtgcagc tggtggagtc tgggggagga ttggtgaaga ctgggggctc tctgagactc       60

tcctgtgcag cctctggccg caccttcagt acctacagca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcaggt atgcgctgga cgggtagtag tacattctac      180

tcagactccg tgaagggccg attcaccgtc tccagaaaca acgccaagga cacggtgtat      240

ctgcacatga acagcctgaa acctgaggac acggccgttt attactgtgc aatcacgact      300

atcgtaagag cttactatac tgagtatacc gaagctgact ttggttcctg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  26
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 H-chain (RCSB.org structures)

<400>  26

Thr Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly 
1               5                   10                  15      


Glu Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Ile Thr 
            20                  25                  30          


Tyr Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Met Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser 
    50                  55                  60                  


Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys His 
    210                 215                 220                 


His His His His His 
225                 


<210>  27
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 H-chain (RCSB.org structures) #2

<400>  27

Gln Met Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Gly Phe Ile Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Ser Glu Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Gly Ser Gly Ile Ser Thr Pro Met Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  28
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 L-chain (RCSB.org structures) #1

<400>  28

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  29
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CR3022 L-chain (RCSB.org structures) #2

<400>  29

Asp Ile Gln Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Ile Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Ser 
    210                 215                 220     


<210>  30
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EY6A H-chain (RCSB.org structures)

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ala Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Lys Leu Trp Val Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys 
225     


<210>  31
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EY6A L-chain (RCSB.org structures)

<400>  31

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Leu Ala 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  32
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH-72 nanobody (RCSB.org structures 
       https://www.rcsb.org/structure/6waq)

<400>  32

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
        115                 120                 125         


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11 CDR1

<400>  33

Gly Arg Thr Phe Ser Thr Ala Ala 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11 CDR2

<400>  34

Ile Arg Trp Ser Gly Gly Ser Ala 
1               5               


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11 CDR3

<400>  35

Ala Gln Thr Arg Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A7 CDR1

<400>  36

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A7 CDR2

<400>  37

Ile Ser Trp Asn Gly Gly Gly Thr 
1               5               


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A7 CDR3

<400>  38

Ala Lys Asp Phe His Arg Tyr Gly Ser Ser Thr Leu Glu Tyr Asp Tyr 
1               5                   10                  15      


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F9 CDR1

<400>  39

Gly Phe Thr Phe Ser Ser Tyr Phe 
1               5               


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F9 CDR2

<400>  40

Ile Gly Asp Arg Gly Asn Thr 
1               5           


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F9 CDR3

<400>  41

Tyr Ser Arg Asn Arg Ile Leu Gln His Tyr 
1               5                   10  


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10 CDR1

<400>  42

Gly Phe Ala Phe Ser Ser Tyr Asp 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10 CDR2

<400>  43

Ile Asp Ser Gly Gly Gly Val Thr 
1               5               


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10 CDR3

<400>  44

Asn Ala Val Asp Gly Leu Gly Tyr Leu Glu Tyr Asp Tyr 
1               5                   10              


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B1 CDR1

<400>  45

Gly Phe Thr Phe Asp Asp Tyr Ala 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 CDR2

<400>  46

Ile Tyr Ser Tyr Ile Ser Thr Thr 
1               5               


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 CDR3

<400>  47

Ala Ala Arg Arg Leu Asp Thr Thr Asp Tyr Lys Tyr 
1               5                   10          


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E11 CDR1

<400>  48

Gly Phe Thr Phe Ser Asn Tyr Ala 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E11 CDR2

<400>  49

Ile Gly Ser Asp Gly Arg His Pro 
1               5               


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E11 CDR3

<400>  50

Leu Pro Gly Trp Ser Thr Val Gly Thr Phe Leu Asp Ala 
1               5                   10              


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1 CDR1

<400>  51

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1 CDR2

<400>  52

Ile Asn Ser Gly Gly Gly Ser Thr 
1               5               


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1 CDR3

<400>  53

Ala Lys Asp Ala Ser Glu Asp Ala Gly Arg Leu Tyr Trp Thr Asp Tyr 
1               5                   10                  15      


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G7 CDR1

<400>  54

Gly Phe Thr Phe Asp Thr Tyr Asp 
1               5               


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G7 CDR2

<400>  55

Glu Asp Ser Thr Gly Asn Lys 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G7 CDR3

<400>  56

Ala Lys Gly Leu Arg Ser Trp Gly Ala 
1               5                   


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 CDR1

<400>  57

Gly Thr Ile Phe Arg Ile Asn Ala 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 CDR2

<400>  58

Ile Ser Asn Gly Asp Ser Gly Asp 
1               5               


<210>  59
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 CDR3

<400>  59

Tyr Cys Asn Val Glu Ala Ser Trp Pro His Lys Tyr 
1               5                   10          


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G11 CDR1

<400>  60

Gly Phe Thr Phe Asp Asp Tyr Gly 
1               5               


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G11 CDR2

<400>  61

Val Asn Ser Gly Gly Gly Thr 
1               5           


<210>  62
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G11 CDR3

<400>  62

Ala Lys Arg Asp Gly Ser Trp Trp Gly Tyr Thr Thr Asp Tyr 
1               5                   10                  


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4 CDR1

<400>  63

Gly Phe Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4 CDR2

<400>  64

Ile Asn Thr Gly Gly Asp Thr Thr 
1               5               


<210>  65
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4 CDR3

<400>  65

Ala Arg Thr Gly Val Val Arg Gly Pro Gly Asp Leu Asp Ala 
1               5                   10                  


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G9 CDR1

<400>  66

Gly Phe Thr Phe Tyr Asp Tyr His 
1               5               


<210>  67
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G9 CDR2

<400>  67

Ile Asp Thr Gly Gly Gly Arg Thr 
1               5               


<210>  68
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G9 CDR3

<400>  68

Val Arg Asp Gly Asp Ala Arg Gly Pro Asp Tyr Asp Tyr 
1               5                   10              


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7 CDR1

<400>  69

Gly Phe Thr Phe Ser Ser Tyr Asp 
1               5               


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7 CDR2

<400>  70

Ile Ser Gly Ser Asp Ser Thr Thr 
1               5               


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7 CDR3

<400>  71

Ala Arg Pro Leu Gly Gln Tyr Thr Ser 
1               5                   


<210>  72
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-D4 CDR3

<400>  72

Ala Arg Thr Glu Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  73
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-H4 CDR3

<400>  73

Ala Gln Thr His Tyr Val Ser Tyr Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  74
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-H6 CDR3

<400>  74

Ala Gly Ser Lys Ile Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  75
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-A10 CDR3

<400>  75

Ala Gly Phe Ser Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  76
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_B5 CDR3

<400>  76

Ala Ser Tyr Gln Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-A7 CDR3

<400>  77

Ala Gln Thr Asp Asn Val Arg Ala Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-F7 CDR3

<400>  78

Ala Ile Phe Ser Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  79
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-F6 CDR3

<400>  79

Ala Arg Thr Ser Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  80
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-G8 CDR3

<400>  80

Ala Gly Ser Gly Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  81
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-D1 CDR3

<400>  81

Ala Gly Trp Arg Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  82
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-A9 CDR3

<400>  82

Ala Pro Tyr Glu Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  83
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-C6 CDR3

<400>  83

Ala Gln Thr Gly Tyr Thr Ser Trp Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  84
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-E3 CDR3

<400>  84

Ala Val Tyr His Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-F4 CDR3

<400>  85

Ala Glu Ser Thr Ile Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  86
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-C5 CDR3

<400>  86

Ala Gln Thr Ser Tyr Val Ser Phe Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  87
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-C2 CDR3

<400>  87

Ala Gly Ser Arg Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  88
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-B11 CDR3

<400>  88

Ala Glu Thr Leu Asn Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  89
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-A3 CDR3

<400>  89

Ala Arg Ser Asp Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  90
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-D12 CDR3

<400>  90

Ala Asp Trp Gly Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  91
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-D6 CDR3

<400>  91

Ala Ser Ser Ser Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  92
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11-F8 CDR3

<400>  92

Ala Asp Ala Ser Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
1               5                   10                  15      


Pro Tyr Asp Tyr 
            20  


<210>  93
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11 amino acid

<400>  93

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Thr Arg Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  94
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A7 amino acid

<400>  94

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Trp Asn Gly Gly Gly Thr Tyr Tyr Ala Glu Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Phe His Arg Tyr Gly Ser Ser Thr Leu Glu Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  95
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F9 amino acid

<400>  95

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Thr Ile Gly Asp Arg Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Tyr 
                85                  90                  95      


Ser Arg Asn Arg Ile Leu Gln His Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  96
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C10 amino acid

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Ser Gly Gly Gly Val Thr Tyr Tyr Ala Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Val Asp Gly Leu Gly Tyr Leu Glu Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  97
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B11 amino acid

<400>  97

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Tyr Ser Tyr Ile Ser Thr Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Arg Leu Asp Thr Thr Asp Tyr Lys Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  98
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E11 amino acid

<400>  98

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Asp Ile Gly Ser Asp Gly Arg His Pro Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Tyr Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Leu Pro Gly Trp Ser Thr Val Gly Thr Phe Leu Asp Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  99
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D1 amino acid

<400>  99

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Ser Gly Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ala Ser Glu Asp Ala Gly Arg Leu Tyr Trp Thr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  100
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G7 amino acid

<400>  100

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Asp Thr Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Asn Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Glu Asp Ser Thr Gly Asn Lys Phe Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Leu Arg Ser Trp Gly Ala Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  101
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F5 amino acid

<400>  101

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Arg Ile Asn 
            20                  25                  30          


Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ile Ile Ser Asn Gly Asp Ser Gly Asp Ser Thr Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Asn Val Glu Ala Ser Trp Pro His Lys Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  102
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G11 amino acid

<400>  102

Gln Val His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Val Asn Ser Gly Gly Gly Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Arg Asp Gly Ser Trp Trp Gly Tyr Thr Thr Asp Tyr Trp Gly Lys 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  103
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B4 amino acid

<400>  103

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asn Thr Gly Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Glu Asn Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Val Val Arg Gly Pro Gly Asp Leu Asp Ala Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  104
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G9 amino acid

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Asp Tyr 
            20                  25                  30          


His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Thr Gly Gly Gly Arg Thr Tyr Ala Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Gly Asp Ala Arg Gly Pro Asp Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  105
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7

<400>  105

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Asp Ser Thr Thr Val Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Lys Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Pro Leu Gly Gln Tyr Thr Ser Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  106
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11

<400>  106
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acaaacgcgg      300

gtcacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  107
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A7

<400>  107
caggtgcagc tggtagagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacttttgat gattatgcca tgagctgggt ccgacaggct      120

ccagggaagg ggctggagtg ggtctcagct attagctgga atggtggtgg cacatactat      180

gcagaatcca tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagatttt      300

catcgatacg gtagtagcac tttggagtat gactactggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  108
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F9

<400>  108
caggtgcagc tggtagagtc tgggggaggc ttggtgcagc ctggggggtc tctgagagtc       60

tcctgtgcag cctctggatt caccttcagt agctacttca tgagctgggt ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcgact attggtgatc gtggtaacac aaactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac agtgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtctatt actgttattc aagaaaccgt      300

atcttgcaac actactgggg ccaggggaca caggtcaccg tctcctca                   348


<210>  109
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C10

<400>  109
caggtgcagc tggtagagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cgccttcagt agctatgaca tgagctgggt ccgccaggct      120

ccagggaagg gactcgaatg ggtctcagcg attgatagtg gtggtggtgt cacatactat      180

gcagactcca tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgtgt attactgtaa tgcagtagac      300

ggcttggggt acttagagta tgactactgg ggccagggga cccaggtcac cgtctcctca      360


<210>  110
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B11

<400>  110
caggtgcagc tggtagagtc tgggggaggc ttggtacagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacttttgat gattatgcca tgagctgggt ccgacaggct      120

ccagggaagg ggctggagtg ggtgtccaat atttatagtt acattagtac cacacactat      180

gcagactccg tgaagggccg attcaccatc tccacagaca acgccaagaa cacactgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agcccgaaga      300

cttgacacga ccgactataa atactggggc caggggacac aggtcaccgt ctcctca         357


<210>  111
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E11

<400>  111
caggtgcagc tggtagagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactatgcca tgacctgggt ccgccaggct      120

ccaggaaagg ggctcgagtg gatctcagat attggtagtg atggtaggca cccagcctat      180

gcagactccg tgaagggccg atacaccatc tccagagaca acgccaagaa cacgctatat      240

ctgcaaatga acagcctgaa acctgaggac acggccatgt attactgtct cccgggttgg      300

agtaccgtcg ggactttttt ggacgcatgg ggccagggga cccaggtcac cgtctcctca      360


<210>  112
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  D1

<400>  112
caggtgcagc tggtagagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatggca tgagctgggt ccgccaggct      120

ccaggaaagg ggctcgagtg ggtctcaggt attaatagtg gtggtggtag cacaagctat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      240

ctgcaaatga acagtctgaa atctgaggac acggccgtgt attactgtgc aaaagacgct      300

agtgaagatg cggggcgact atactggacc gactactggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  113
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G7

<400>  113
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggttc tctgagactc       60

tcctgtgcaa cctctggatt caccttcgat acgtatgaca tgagctgggt ccgccaggct      120

ccaggaaacg ggcccgagtg ggtctcagcg gaggatagta ctgggaacaa attctatgca      180

gactctgtga agggccgatt cgccatctcc agagacaacg ccaggaacac actatatctg      240

caaatgaaca gtctgacatc tgaagacacg gccgtgtatt actgtgcaaa aggtctacga      300

tcctggggtg cctggggcca ggggacccag gtcaccgtct cctca                      345


<210>  114
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F5

<400>  114
caggtgcagc tggtagagtc tgggggaggc ttggtgcagg ctggggggtc tctgagactc       60

tcctgtgcag cctctggaac catcttcaga atcaatgcca tggcctggta ccgccaggct      120

ccagggaagc agcgcgagtt ggtcgcaatt atttctaatg gtgatagtgg tgatagtaca      180

aactatgcag actccgtgaa gggccgattc accatctcca gagacagcgc caagaacacg      240

gtgtatctgc aaatgaacag cctgaaacct gaggacacag ccgtctatta ctgtaatgta      300

gaagcgtcct ggccccataa gtactggggc caggggaccc aggtcaccgt ctcctca         357


<210>  115
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G11

<400>  115
caggtgcacc tggtagagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacttttgat gattatggca tgacctgggt ccgccaggct      120

ccaggaaagg ggctcgagtg ggtctcagcg gttaatagtg gtggtggtac aagctatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac gctgtatctg      240

caaatgaaca gcctgaaacc tgaggacacg gccgtgtatt actgtgcaaa aagagatggt      300

agttggtggg gttataccac ggactactgg ggcaaaggga cccaggtcac cgtctcctca      360


<210>  116
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B4

<400>  116
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctactgga tgtattgggt ccgtcaggct      120

ccagggaagg ggctcgagtg ggtctcagta attaatactg gtggtgatac tacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgacgagaa cacgctgtct      240

ctgcaaatga acagcctgaa acctgaggac acggccctgt attactgtgc gagaacaggg      300

gtagtacgtg gtccgggcga tttggacgca tggggccagg ggacccaggt caccgtctcc      360

tca                                                                    363


<210>  117
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  G9

<400>  117
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cactttttat gattatcaca tgagctgggt ccgccaggct      120

ccagggaagg ggctcgagtg ggtctcaggt atcgatactg gtggtgggcg cacatacgct      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacactgtat      240

ctgcaaatga acagcctgaa atctgaggac acggccctgt attattgtgt gagagatgga      300

gatgcacggg ggcccgacta tgactactgg ggccagggga ccatggtcac cgtctcctca      360


<210>  118
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C7

<400>  118
caggtgcagc tggtagagtc tgggggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcagt agctatgaca tgagctgggt ccgccaggct      120

ccaggaaagg ggctcgagtg ggtctcaggt attagcggaa gtgatagtac tacagtctat      180

tcagactccg tgaaggaccg attcaccatc tccagagaca acgccaagaa tacgttgtat      240

ctgcaaatga acaaactgaa acctgaggac acggccctgt attactgtgc aagaccattg      300

ggacaataca cgagttgggg ccaggggacc caggtcaccg tctcctca                   348


<210>  119
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_D4 amino acid

<400>  119

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Glu Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  120
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_H4 amino acid

<400>  120

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Thr His Tyr Val Ser Tyr Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  121
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_H6 amino acid

<400>  121

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Lys Ile Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  122
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_A10 maino acid

<400>  122

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Phe Ser Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  123
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_B5 amino acid

<400>  123

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Tyr Gln Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  124
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_A7 amino acid

<400>  124

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Thr Asp Asn Val Arg Ala Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  125
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_F7

<400>  125

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Phe Ser Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  126
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_F6 amino acid

<400>  126

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ser Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  127
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_G8 amino acid

<400>  127

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Gly Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  128
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_D1 amino acid

<400>  128

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Trp Arg Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  129
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_A9 amino acid

<400>  129

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Pro Tyr Glu Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  130
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_C6 amino acid

<400>  130

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Thr Gly Tyr Thr Ser Trp Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  131
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_E3 amino acid

<400>  131

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Tyr His Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  132
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_F4 amino acid

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Ser Thr Ile Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  133
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_C5 amino acid

<400>  133

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Thr Ser Tyr Val Ser Phe Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  134
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_C2 amino acid

<400>  134

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Ser Arg Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  135
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_B11 amino acid

<400>  135

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Glu Thr Leu Asn Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  136
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_A3 amino acid

<400>  136

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Asp Asn Val Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  137
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_D12 amino acid

<400>  137

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Trp Gly Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  138
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_D6 amino acid

<400>  138

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Ser Val Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  139
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H11_F8 amino acid

<400>  139

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Met Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asp Ala Ser Ala Thr Arg Ser Leu Leu Ser Asp Tyr Ala Thr Trp 
            100                 105                 110         


Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  140
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_D4

<400>  140
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acggacggag      300

aatgttcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  141
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_H4

<400>  141
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acaaacgcat      300

tatgtttctt atctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  142
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_H6

<400>  142
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc aggttctaag      300

attacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  143
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_A10

<400>  143
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc aggttttagt      300

gcgactcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  144
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_B5

<400>  144
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc aagttatcag      300

gcgactcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  145
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_A7

<400>  145
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acaaacggat      300

aatgtgcggg cgctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  146
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_F7

<400>  146
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc aattttttct      300

aatgtgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  147
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_F6

<400>  147
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acggacgtcg      300

aatgtgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  148
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_G8

<400>  148
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc agggtctggt      300

gtgacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  149
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_D1

<400>  149
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc agggtggcgt      300

gcgacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  150
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_A9

<400>  150
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc accgtatgag      300

gctacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  151
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_C6

<400>  151
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acaaacgggt      300

tatacgtctt ggctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  152
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_E3

<400>  152
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc agtgtatcat      300

gctactcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  153
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_F4

<400>  153
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc agagagtacg      300

attactcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  154
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_C5

<400>  154
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acaaacgtcg      300

tatgtgagtt ttctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  155
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_C2

<400>  155
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc aggtagtcgg      300

gcgacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  156
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_B11

<400>  156
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc agagacgttg      300

aatactcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  157
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_A3

<400>  157
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc acgttctgat      300

aatgtgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  158
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_D12

<400>  158
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc agattggggt      300

gtgactcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  159
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_D6

<400>  159
caggtgcagc tggtggagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc aagttcttct      300

gtgacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  160
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H11_F8

<400>  160
caggtgcagc tggtcgagtc tgggggagga ttgatgcagg ctgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attaggtgga gtggtggtag cgcatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca aggccaagaa cacggtatat      240

ctgcaaatga acagcctgaa atatgaggac acggccgttt attactgtgc agatgcttcg      300

gcgacgcggt ccctccttag cgactatgcc acttggcctt atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  161
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-Fc

<400>  161
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggggggtc tctgacactc       60

tcctgtgtcg cctctggagt cactttggga cgtcatgcca taggctggtt ccgccaggcc      120

cccgggaagg agcgtgagag agtctcgtgt attagaacat ttgatggcat cacaagttat      180

gtagagtcca cgaagggccg attcaccatc tccagtaaca atgccatgaa cacggtgtat      240

ctgcaaatga atagcctcaa acctgaagac acggccgttt atttctgtgc actgggagtg      300

actgcagcct gttcagataa tccctacttc tggggccagg ggacccaggt caccgtctcc      360

tcagcgtcga ccgagcccaa atcttgtgac aaaactcaca catgcccacc gtgcccagca      420

cctgaactcc tggggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc      480

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct      540

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg      600

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag      660

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cccagccccc      720

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg      780

cccccatccc gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc      840

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac      900

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctatag caagctcacc      960

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1020

ctgcacaacc actacacgca gaagagcctc tccctgtccc cgggtaaa                  1068


<210>  162
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-AAA-C5 (OmpA)

<400>  162
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctcaggtgc agctggtcga gtctggggga ggctcggtgc aggctggggg gtctctgaca      120

ctctcctgtg tcgcctctgg agtcactttg ggacgtcatg ccataggctg gttccgccag      180

gcccccggga aggagcgtga gagagtctcg tgtattagaa catttgatgg catcacaagt      240

tatgtagagt ccacgaaggg ccgattcacc atctccagta acaatgccat gaacacggtg      300

tatctgcaaa tgaatagcct caaacctgaa gacacggccg tttatttctg tgcactggga      360

gtgactgcag cctgttcaga taatccctac ttctggggcc aggggaccca ggtcaccgtc      420

tcctcagcag cagcacaggt gcagctggtc gagtctgggg gaggctcggt gcaggctggg      480

gggtctctga cactctcctg tgtcgcctct ggagtcactt tgggacgtca tgccataggc      540

tggttccgcc aggcccccgg gaaggagcgt gagagagtct cgtgtattag aacatttgat      600

ggcatcacaa gttatgtaga gtccacgaag ggccgattca ccatctccag taacaatgcc      660

atgaacacgg tgtatctgca aatgaatagc ctcaaacctg aagacacggc cgtttatttc      720

tgtgcactgg gagtgactgc agcctgttca gataatccct acttctgggg ccaggggacc      780

caggtcaccg tctcctcaaa acatcaccat caccatcact aa                         822


<210>  163
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-9GS-C5

<400>  163
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctcaggtgc agctggtcga gtctggggga ggctcggtgc aggctggggg gtctctgaca      120

ctctcctgtg tcgcctctgg agtcactttg ggacgtcatg ccataggctg gttccgccag      180

gcccccggga aggagcgtga gagagtctcg tgtattagaa catttgatgg catcacaagt      240

tatgtagagt ccacgaaggg ccgattcacc atctccagta acaatgccat gaacacggtg      300

tatctgcaaa tgaatagcct caaacctgaa gacacggccg tttatttctg tgcactggga      360

gtgactgcag cctgttcaga taatccctac ttctggggcc aggggaccca ggtcaccgtc      420

tcctcaggcg gcgggggatc aggtggtggc agtcaggtgc agctggtgga gtctggggga      480

ggctcggtgc aggctggggg gtctctgaca ctctcctgtg tcgcctctgg agtcactttg      540

ggacgtcatg ccataggctg gttccgccag gcccccggga aggagcgtga gagagtctcg      600

tgtattagaa catttgatgg catcacaagt tatgtagagt ccacgaaggg ccgattcacc      660

atctccagta acaatgccat gaacacggtg tatctgcaaa tgaatagcct caaacctgaa      720

gacacggccg tttatttctg tgcactggga gtgactgcag cctgttcaga taatccctac      780

ttctggggcc aggggaccca ggtcaccgtc tcctcaaaac atcaccatca ccatcactaa      840


<210>  164
<211>  1131
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-SUMO-C5

<400>  164
atgaaaaaga cagctatcgc aattgcagtg gccttggctg gtttcgctac cgtagcgcaa       60

gctcaggtgc agctggtcga gtctggggga ggctcggtgc aggctggggg gtctctgaca      120

ctctcctgtg tcgcctctgg agtcactttg ggacgtcatg ccataggctg gttccgccag      180

gcccccggga aggagcgtga gagagtctcg tgtattagaa catttgatgg catcacaagt      240

tatgtagagt ccacgaaggg ccgattcacc atctccagta acaatgccat gaacacggtg      300

tatctgcaaa tgaatagcct caaacctgaa gacacggccg tttatttctg tgcactggga      360

gtgactgcag cctgttcaga taatccctac ttctggggcc aggggaccca ggtcaccgtc      420

tcctcaggga gcggttctgg ctccgatagc gaagtgaacc aggaagcgaa accggaagtt      480

aaaccggaag tgaaaccgga aacccatatt aatctgaaag ttagcgacgg cagcagcgaa      540

atctttttta aaattaaaaa aaccaccccg ctgcgtcgcc tgatggaagc ctttgcgaaa      600

cgtcagggta aagaaatgga tagcctgcgc tttctgtatg acggcatccg tattcaggcc      660

gatcagaccc cggaagacct ggatatggaa gacaacgata ttattgaagc gcatcgcgaa      720

cagatcggct caggtagcgg gtcgcaggtg cagctggtgg agtctggggg aggctcggtg      780

caggctgggg ggtctctgac actctcctgt gtcgcctctg gagtcacttt gggacgtcat      840

gccataggct ggttccgcca ggcccccggg aaggagcgtg agagagtctc gtgtattaga      900

acatttgatg gcatcacaag ttatgtagag tccacgaagg gccgattcac catctccagt      960

aacaatgcca tgaacacggt gtatctgcaa atgaatagcc tcaaacctga agacacggcc     1020

gtttatttct gtgcactggg agtgactgca gcctgttcag ataatcccta cttctggggc     1080

caggggaccc aggtcaccgt ctcctcaaaa catcaccatc accatcacta a              1131


<210>  165
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-GSGSGS-SUMO-GSGSGS-C5

<400>  165
caggtgcagc tggtggagtc tgggggaggc tcggtgcagg ctggggggtc tctgacactc       60

tcctgtgtcg cctctggagt cactttggga cgtcatgcca taggctggtt ccgccaggcc      120

cccgggaagg agcgtgagag agtctcgtgt attagaacat ttgatggcat cacaagttat      180

gtagagtcca cgaagggccg attcaccatc tccagtaaca atgccatgaa cacggtgtat      240

ctgcaaatga atagcctcaa acctgaagac acggccgttt atttctgtgc actgggagtg      300

actgcagcct gttcagataa tccctacttc tggggccagg ggacccaggt caccgtctcc      360

tcagggagcg gttctggctc cgatagcgaa gtgaaccagg aagcgaaacc ggaagttaaa      420

ccggaagtga aaccggaaac ccatattaat ctgaaagtta gcgacggcag cagcgaaatc      480

ttttttaaaa ttaaaaaaac caccccgctg cgtcgcctga tggaagcctt tgcgaaacgt      540

cagggtaaag aaatggatag cctgcgcttt ctgtatgacg gcatccgtat tcaggccgat      600

cagaccccgg aagacctgga tatggaagac aacgatatta ttgaagcgca tcgcgaacag      660

atcggctcag gtagcgggtc gcaggtgcag ctggtggagt ctgggggagg attggtgcag      720

gctgggggct ctctaagact cgcttgtata gcctctggac gcaccttcca tagctatgtc      780

atggcctggt tccgccaggc tccagggaag gagcgtgagt ttgtagcagc tattagttgg      840

agtagtacac cgacatacta tggagaatcc gtgaagggcc gattcaccat ctccagagac      900

aacgccaaga acacggtgta tctgcaaatg aaccgcctga aacctgagga cacggccgtt      960

tatttctgtg cagcagaccg gggtgaaagt tactactaca ctcgacccac cgagtatgaa     1020

ttctggggcc aggggaccca ggtcaccgtc tcctca                               1056


<210>  166
<211>  1056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F2-SUMO-C5

<400>  166
caggtgcagc tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctaagactc       60

gcttgtatag cctctggacg caccttccat agctatgtca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attagttgga gtagtacacc gacatactat      180

ggagaatccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga accgcctgaa acctgaggac acggccgttt atttctgtgc agcagaccgg      300

ggtgaaagtt actactacac tcgacccacc gagtatgaat tctggggcca ggggacccag      360

gtcaccgtct cctcagggag cggttctggc tccgatagcg aagtgaacca ggaagcgaaa      420

ccggaagtta aaccggaagt gaaaccggaa acccatatta atctgaaagt tagcgacggc      480

agcagcgaaa tcttttttaa aattaaaaaa accaccccgc tgcgtcgcct gatggaagcc      540

tttgcgaaac gtcagggtaa agaaatggat agcctgcgct ttctgtatga cggcatccgt      600

attcaggccg atcagacccc ggaagacctg gatatggaag acaacgatat tattgaagcg      660

catcgcgaac agatcggctc aggtagcggg tcgcaggtgc agctggtgga gtctggggga      720

ggctcggtgc aggctggggg gtctctgaca ctctcctgtg tcgcctctgg agtcactttg      780

ggacgtcatg ccataggctg gttccgccag gcccccggga aggagcgtga gagagtctcg      840

tgtattagaa catttgatgg catcacaagt tatgtagagt ccacgaaggg ccgattcacc      900

atctccagta acaatgccat gaacacggtg tatctgcaaa tgaatagcct caaacctgaa      960

gacacggccg tttatttctg tgcactggga gtgactgcag cctgttcaga taatccctac     1020

ttctggggcc aggggaccca ggtcaccgtc tcctca                               1056


<210>  167
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1-SUMO-C5

<400>  167
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc       60

tcctgtgcag cctctggatt cactaatgat ttttatagca tcgcgtggtt ccgccaggcc      120

ccaggaaagg agcgtgaggg ggtctcatgg cttagtgtca gtgataatac cccaacctac      180

gtagactccg tgaaggaccg gttcaccatc tccagacaca acgccaacaa caccgtgtac      240

ctgcaaatga acatgctgaa acctgaggac acggccattt actattgtgc agcaggacgc      300

ttcgcgggaa gggatacttg gccctcgtcc tatgattact ggggccaggg gacccaggtc      360

accgtctcct cagggagcgg ttctggctcc gatagcgaag tgaaccagga agcgaaaccg      420

gaagttaaac cggaagtgaa accggaaacc catattaatc tgaaagttag cgacggcagc      480

agcgaaatct tttttaaaat taaaaaaacc accccgctgc gtcgcctgat ggaagccttt      540

gcgaaacgtc agggtaaaga aatggatagc ctgcgctttc tgtatgacgg catccgtatt      600

caggccgatc agaccccgga agacctggat atggaagaca acgatattat tgaagcgcat      660

cgcgaacaga tcggctcagg tagcgggtcg caggtgcagc tggtggagtc tgggggaggc      720

tcggtgcagg ctggggggtc tctgacactc tcctgtgtcg cctctggagt cactttggga      780

cgtcatgcca taggctggtt ccgccaggcc cccgggaagg agcgtgagag agtctcgtgt      840

attagaacat ttgatggcat cacaagttat gtagagtcca cgaagggccg attcaccatc      900

tccagtaaca atgccatgaa cacggtgtat ctgcaaatga atagcctcaa acctgaagac      960

acggccgttt atttctgtgc actgggagtg actgcagcct gttcagataa tccctacttc     1020

tggggccagg ggacccaggt caccgtctcc tca                                  1053


<210>  168
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1-SUMO-H3

<400>  168
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc       60

tcctgtgcag cctctggatt cactaatgat ttttatagca tcgcgtggtt ccgccaggcc      120

ccaggaaagg agcgtgaggg ggtctcatgg cttagtgtca gtgataatac cccaacctac      180

gtagactccg tgaaggaccg gttcaccatc tccagacaca acgccaacaa caccgtgtac      240

ctgcaaatga acatgctgaa acctgaggac acggccattt actattgtgc agcaggacgc      300

ttcgcgggaa gggatacttg gccctcgtcc tatgattact ggggccaggg gacccaggtc      360

accgtctcct cagggagcgg ttctggctcc gatagcgaag tgaaccagga agcgaaaccg      420

gaagttaaac cggaagtgaa accggaaacc catattaatc tgaaagttag cgacggcagc      480

agcgaaatct tttttaaaat taaaaaaacc accccgctgc gtcgcctgat ggaagccttt      540

gcgaaacgtc agggtaaaga aatggatagc ctgcgctttc tgtatgacgg catccgtatt      600

caggccgatc agaccccgga agacctggat atggaagaca acgatattat tgaagcgcat      660

cgcgaacaga tcggctcagg tagcgggtcg caggtgcagc tggtggagtc tgggggagga      720

ttggtgaaga ctgggggctc tctgagactc tcctgtgcag cctctggccg caccttcagt      780

acctacagca tgggctggtt ccgccaggct ccagggaagg agcgtgagtt tgtagcaggt      840

atgcgctgga cgggtagtag tacattctac tcagactccg tgaagggccg attcaccgtc      900

tccagaaaca acgccaagga cacggtgtat ctgcacatga acagcctgaa acctgaggac      960

acggccgttt attactgtgc aatcacgact atcgtaagag cttactatac tgagtatacc     1020

gaagctgact ttggttcctg gggccagggg acccaggtca ccgtctcctc a              1071


<210>  169
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hIgG1-Fc

<400>  169
gcgtcgaccg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct       60

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      120

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      180

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      240

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      300

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      360

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      420

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      480

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      540

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg      600

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg      660

cacaaccact acacgcagaa gagcctctcc ctgtccccgg gtaaa                      705


<210>  170
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5 fused to the Fc region of hIgG1

<400>  170

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ser Thr Glu Pro Lys Ser 
        115                 120                 125             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    130                 135                 140                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        195                 200                 205             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Lys 
        355     


<210>  171
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-AAA-C5

<400>  171

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser 
65                  70                  75                  80  


Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala 
                85                  90                  95      


Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn 
        115                 120                 125             


Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
    130                 135                 140                 


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly 
145                 150                 155                 160 


Gly Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg 
                165                 170                 175     


His Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg 
            180                 185                 190         


Val Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser 
        195                 200                 205             


Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe 
225                 230                 235                 240 


Cys Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp 
                245                 250                 255     


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Lys His His His His His 
            260                 265                 270         


His 
    


<210>  172
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-9GS-C5

<400>  172

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser 
65                  70                  75                  80  


Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala 
                85                  90                  95      


Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn 
        115                 120                 125             


Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
145                 150                 155                 160 


Gly Ser Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser 
                165                 170                 175     


Gly Val Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro 
            180                 185                 190         


Gly Lys Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile 
        195                 200                 205             


Thr Ser Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn 
    210                 215                 220                 


Asn Ala Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser 
                245                 250                 255     


Asp Asn Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Lys His His His His His His 
        275                 


<210>  173
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-GSGSGS-SUMO-GSGSGS-C5

<400>  173

Met Lys Lys Thr Ala Ile Ala Ile Ala Val Ala Leu Ala Gly Phe Ala 
1               5                   10                  15      


Thr Val Ala Gln Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser 
            20                  25                  30          


Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val 
        35                  40                  45              


Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser 
65                  70                  75                  80  


Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala 
                85                  90                  95      


Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn 
        115                 120                 125             


Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
    130                 135                 140                 


Gly Ser Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val 
145                 150                 155                 160 


Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp 
                165                 170                 175     


Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg 
            180                 185                 190         


Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser 
        195                 200                 205             


Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro 
    210                 215                 220                 


Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu 
225                 230                 235                 240 


Gln Ile Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
                245                 250                 255     


Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala 
            260                 265                 270         


Ser Gly Val Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly 
    290                 295                 300                 


Ile Thr Ser Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser 
305                 310                 315                 320 


Asn Asn Ala Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys 
            340                 345                 350         


Ser Asp Asn Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        355                 360                 365             


Ser Lys His His His His His His 
    370                 375     


<210>  174
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-GSGSGS-SUMO-GSGSGS-F2

<400>  174

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Asp 
        115                 120                 125             


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
    130                 135                 140                 


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
145                 150                 155                 160 


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
                165                 170                 175     


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr 
            180                 185                 190         


Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
        195                 200                 205             


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
225                 230                 235                 240 


Ala Gly Gly Ser Leu Arg Leu Ala Cys Ile Ala Ser Gly Arg Thr Phe 
                245                 250                 255     


His Ser Tyr Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            260                 265                 270         


Glu Phe Val Ala Ala Ile Ser Trp Ser Ser Thr Pro Thr Tyr Tyr Gly 
        275                 280                 285             


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
    290                 295                 300                 


Thr Val Tyr Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val 
305                 310                 315                 320 


Tyr Phe Cys Ala Ala Asp Arg Gly Glu Ser Tyr Tyr Tyr Thr Arg Pro 
                325                 330                 335     


Thr Glu Tyr Glu Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            340                 345                 350         


<210>  175
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2-GSGSGS-SUMO-GSGSGS-C5

<400>  175

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ile Ala Ser Gly Arg Thr Phe His Ser Tyr 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Ser Thr Pro Thr Tyr Tyr Gly Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Glu Ser Tyr Tyr Tyr Thr Arg Pro Thr Glu Tyr 
            100                 105                 110         


Glu Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys 
    130                 135                 140                 


Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly 
145                 150                 155                 160 


Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg 
                165                 170                 175     


Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu 
            180                 185                 190         


Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu 
        195                 200                 205             


Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln 
    210                 215                 220                 


Ile Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
225                 230                 235                 240 


Gly Ser Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser 
                245                 250                 255     


Gly Val Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile 
        275                 280                 285             


Thr Ser Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn 
    290                 295                 300                 


Asn Ala Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
305                 310                 315                 320 


Asp Thr Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser 
                325                 330                 335     


Asp Asn Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            340                 345                 350         


<210>  176
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1-GSGSGS-SUMO-GSGSGS-C5

<400>  176

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp Phe Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Asn Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
    130                 135                 140                 


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
145                 150                 155                 160 


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
                165                 170                 175     


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
            180                 185                 190         


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
        195                 200                 205             


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
    210                 215                 220                 


Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
225                 230                 235                 240 


Ser Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser Gly 
                245                 250                 255     


Val Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly 
            260                 265                 270         


Lys Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr 
        275                 280                 285             


Ser Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn 
    290                 295                 300                 


Ala Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
305                 310                 315                 320 


Thr Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser Asp 
                325                 330                 335     


Asn Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            340                 345                 350     


<210>  177
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1-GSGSGS-SUMO-GSGSGS-H3

<400>  177

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp Phe Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Asn Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
    130                 135                 140                 


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
145                 150                 155                 160 


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
                165                 170                 175     


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
            180                 185                 190         


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
        195                 200                 205             


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
    210                 215                 220                 


Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
225                 230                 235                 240 


Leu Val Lys Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                245                 250                 255     


Arg Thr Phe Ser Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly 
            260                 265                 270         


Lys Glu Arg Glu Phe Val Ala Gly Met Arg Trp Thr Gly Ser Ser Thr 
        275                 280                 285             


Phe Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asn Asn 
    290                 295                 300                 


Ala Lys Asp Thr Val Tyr Leu His Met Asn Ser Leu Lys Pro Glu Asp 
305                 310                 315                 320 


Thr Ala Val Tyr Tyr Cys Ala Ile Thr Thr Ile Val Arg Ala Tyr Tyr 
                325                 330                 335     


Thr Glu Tyr Thr Glu Ala Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln 
            340                 345                 350         


Val Thr Val Ser 
        355     


<210>  178
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C1-SUMO-H11-H4

<400>  178
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc       60

tcctgtgcag cctctggatt cactaatgat ttttatagca tcgcgtggtt ccgccaggcc      120

ccaggaaagg agcgtgaggg ggtctcatgg cttagtgtca gtgataatac cccaacctac      180

gtagactccg tgaaggaccg gttcaccatc tccagacaca acgccaacaa caccgtgtac      240

ctgcaaatga acatgctgaa acctgaggac acggccattt actattgtgc agcaggacgc      300

ttcgcgggaa gggatacttg gccctcgtcc tatgattact ggggccaggg gacccaggtc      360

accgtctcct cagggagcgg ttctggctcc gatagcgaag tgaaccagga agcgaaaccg      420

gaagttaaac cggaagtgaa accggaaacc catattaatc tgaaagttag cgacggcagc      480

agcgaaatct tttttaaaat taaaaaaacc accccgctgc gtcgcctgat ggaagccttt      540

gcgaaacgtc agggtaaaga aatggatagc ctgcgctttc tgtatgacgg catccgtatt      600

caggccgatc agaccccgga agacctggat atggaagaca acgatattat tgaagcgcat      660

cgcgaacaga tcggctcagg tagcgggtcg caggtgcagc tggtcgagtc tgggggagga      720

ttgatgcagg ctgggggctc tctgagactc tcctgtgcag tctctggacg caccttcagt      780

accgctgcca tgggctggtt ccgccaggct ccagggaagg agcgtgagtt tgtagcagct      840

attaggtgga gtggtggtag cgcatactat gcagactccg tgaagggccg attcaccatc      900

tccagagaca aggccaagaa cacggtatat ctgcaaatga acagcctgaa atatgaggac      960

acggccgttt attactgtgc aggttctaag attacgcggt ccctccttag cgactatgcc     1020

acttggcctt atgactactg gggccagggg acccaggtca ccgtctcctc a              1071


<210>  179
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1-GSGSGS-SUMO-GSGSGS-H11-H4

<400>  179

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp Phe Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Asn Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
    130                 135                 140                 


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
145                 150                 155                 160 


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
                165                 170                 175     


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
            180                 185                 190         


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
        195                 200                 205             


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
    210                 215                 220                 


Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
225                 230                 235                 240 


Leu Met Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly 
                245                 250                 255     


Arg Thr Phe Ser Thr Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
            260                 265                 270         


Lys Glu Arg Glu Phe Val Ala Ala Ile Arg Trp Ser Gly Gly Ser Ala 
        275                 280                 285             


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Lys 
    290                 295                 300                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Tyr Glu Asp 
305                 310                 315                 320 


Thr Ala Val Tyr Tyr Cys Ala Gln Thr His Tyr Val Ser Tyr Leu Leu 
                325                 330                 335     


Ser Asp Tyr Ala Thr Trp Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            340                 345                 350         


Val Thr Val Ser Ser 
        355         


<210>  180
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hIgG1-Fc

<400>  180

Ala Ser Thr Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  181
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-AAA-C5

<400>  181
caggtgcagc tggtcgagtc tgggggaggc tcggtgcagg ctggggggtc tctgacactc       60

tcctgtgtcg cctctggagt cactttggga cgtcatgcca taggctggtt ccgccaggcc      120

cccgggaagg agcgtgagag agtctcgtgt attagaacat ttgatggcat cacaagttat      180

gtagagtcca cgaagggccg attcaccatc tccagtaaca atgccatgaa cacggtgtat      240

ctgcaaatga atagcctcaa acctgaagac acggccgttt atttctgtgc actgggagtg      300

actgcagcct gttcagataa tccctacttc tggggccagg ggacccaggt caccgtctcc      360

tcagcagcag cacaggtgca gctggtcgag tctgggggag gctcggtgca ggctgggggg      420

tctctgacac tctcctgtgt cgcctctgga gtcactttgg gacgtcatgc cataggctgg      480

ttccgccagg cccccgggaa ggagcgtgag agagtctcgt gtattagaac atttgatggc      540

atcacaagtt atgtagagtc cacgaagggc cgattcacca tctccagtaa caatgccatg      600

aacacggtgt atctgcaaat gaatagcctc aaacctgaag acacggccgt ttatttctgt      660

gcactgggag tgactgcagc ctgttcagat aatccctact tctggggcca ggggacccag      720

gtcaccgtct cctca                                                       735


<210>  182
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-AAA-C5

<400>  182

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Thr Leu 
    130                 135                 140                 


Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His Ala Ile Gly Trp 
145                 150                 155                 160 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ser Cys Ile Arg 
                165                 170                 175     


Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala Leu Gly Val 
    210                 215                 220                 


Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly Gln Gly Thr Gln 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  183
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-9GS-C5

<400>  183
caggtgcagc tggtcgagtc tgggggaggc tcggtgcagg ctggggggtc tctgacactc       60

tcctgtgtcg cctctggagt cactttggga cgtcatgcca taggctggtt ccgccaggcc      120

cccgggaagg agcgtgagag agtctcgtgt attagaacat ttgatggcat cacaagttat      180

gtagagtcca cgaagggccg attcaccatc tccagtaaca atgccatgaa cacggtgtat      240

ctgcaaatga atagcctcaa acctgaagac acggccgttt atttctgtgc actgggagtg      300

actgcagcct gttcagataa tccctacttc tggggccagg ggacccaggt caccgtctcc      360

tcaggcggcg ggggatcagg tggtggcagt caggtgcagc tggtggagtc tgggggaggc      420

tcggtgcagg ctggggggtc tctgacactc tcctgtgtcg cctctggagt cactttggga      480

cgtcatgcca taggctggtt ccgccaggcc cccgggaagg agcgtgagag agtctcgtgt      540

attagaacat ttgatggcat cacaagttat gtagagtcca cgaagggccg attcaccatc      600

tccagtaaca atgccatgaa cacggtgtat ctgcaaatga atagcctcaa acctgaagac      660

acggccgttt atttctgtgc actgggagtg actgcagcct gttcagataa tccctacttc      720

tggggccagg ggacccaggt caccgtctcc tca                                   753


<210>  184
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-9GS-C5

<400>  184

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala 
    130                 135                 140                 


Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly 
145                 150                 155                 160 


Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     


Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu 
            180                 185                 190         


Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
    210                 215                 220                 


Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250     


<210>  185
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-SUMO-C5

<400>  185
caggtgcagc tggtcgagtc tgggggaggc tcggtgcagg ctggggggtc tctgacactc       60

tcctgtgtcg cctctggagt cactttggga cgtcatgcca taggctggtt ccgccaggcc      120

cccgggaagg agcgtgagag agtctcgtgt attagaacat ttgatggcat cacaagttat      180

gtagagtcca cgaagggccg attcaccatc tccagtaaca atgccatgaa cacggtgtat      240

ctgcaaatga atagcctcaa acctgaagac acggccgttt atttctgtgc actgggagtg      300

actgcagcct gttcagataa tccctacttc tggggccagg ggacccaggt caccgtctcc      360

tcagggagcg gttctggctc cgatagcgaa gtgaaccagg aagcgaaacc ggaagttaaa      420

ccggaagtga aaccggaaac ccatattaat ctgaaagtta gcgacggcag cagcgaaatc      480

ttttttaaaa ttaaaaaaac caccccgctg cgtcgcctga tggaagcctt tgcgaaacgt      540

cagggtaaag aaatggatag cctgcgcttt ctgtatgacg gcatccgtat tcaggccgat      600

cagaccccgg aagacctgga tatggaagac aacgatatta ttgaagcgca tcgcgaacag      660

atcggctcag gtagcgggtc gcaggtgcag ctggtggagt ctgggggagg ctcggtgcag      720

gctggggggt ctctgacact ctcctgtgtc gcctctggag tcactttggg acgtcatgcc      780

ataggctggt tccgccaggc ccccgggaag gagcgtgaga gagtctcgtg tattagaaca      840

tttgatggca tcacaagtta tgtagagtcc acgaagggcc gattcaccat ctccagtaac      900

aatgccatga acacggtgta tctgcaaatg aatagcctca aacctgaaga cacggccgtt      960

tatttctgtg cactgggagt gactgcagcc tgttcagata atccctactt ctggggccag     1020

gggacccagg tcaccgtctc ctca                                            1044


<210>  186
<211>  348
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-GSGSGS-SUMO-GSGSGS-C5

<400>  186

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Asp 
        115                 120                 125             


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
    130                 135                 140                 


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
145                 150                 155                 160 


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
                165                 170                 175     


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr 
            180                 185                 190         


Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
        195                 200                 205             


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln 
225                 230                 235                 240 


Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu 
                245                 250                 255     


Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
            260                 265                 270         


Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val 
        275                 280                 285             


Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn 
    290                 295                 300                 


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
305                 310                 315                 320 


Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr 
                325                 330                 335     


Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            340                 345             


<210>  187
<211>  1146
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C5-6GS-C5-6GS-C5

<400>  187
caggtgcagc tggtcgagtc tgggggaggc tcggtgcagg ctggggggtc tctgacactc       60

tcctgtgtcg cctctggagt cactttggga cgtcatgcca taggctggtt ccgccaggcc      120

cccgggaagg agcgtgagag agtctcgtgt attagaacat ttgatggcat cacaagttat      180

gtagagtcca cgaagggccg attcaccatc tccagtaaca atgccatgaa cacggtgtat      240

ctgcaaatga atagcctcaa acctgaagac acggccgttt atttctgtgc actgggagtg      300

actgcagcct gttcagataa tccctacttc tggggccagg ggacccaggt caccgtctcc      360

tcagggagcg gttctggctc ccaggtgcag ctggtggagt ctgggggagg ctcggtgcag      420

gctggggggt ctctgacact ctcctgtgtc gcctctggag tcactttggg acgtcatgcc      480

ataggctggt tccgccaggc ccccgggaag gagcgtgaga gagtctcgtg tattagaaca      540

tttgatggca tcacaagtta tgtagagtcc acgaagggcc gattcaccat ctccagtaac      600

aatgccatga acacggtgta tctgcaaatg aatagcctca aacctgaaga cacggccgtt      660

tatttctgtg cactgggagt gactgcagcc tgttcagata atccctactt ctggggccag      720

gggacccagg tcaccgtctc ctcaggctca ggtagcgggt cgcaggtgca gctggtcgag      780

tctgggggag gctcggtgca ggctgggggg tctctgacac tctcctgtgt cgcctctgga      840

gtcactttgg gacgtcatgc cataggctgg ttccgccagg cccccgggaa ggagcgtgag      900

agagtctcgt gtattagaac atttgatggc atcacaagtt atgtagagtc cacgaagggc      960

cgattcacca tctccagtaa caatgccatg aacacggtgt atctgcaaat gaatagcctc     1020

aaacctgaag acacggccgt ttatttctgt gcactgggag tgactgcagc ctgttcagat     1080

aatccctact tctggggcca ggggacccag gtcaccgtct cctcaaaaca tcaccatcac     1140

catcac                                                                1146


<210>  188
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-6GS-C5-6GS-C5

<400>  188

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
    130                 135                 140                 


Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His Ala 
145                 150                 155                 160 


Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ser 
                165                 170                 175     


Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gln Val 
                245                 250                 255     


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
            260                 265                 270         


Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His Ala Ile 
        275                 280                 285             


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ser Cys 
    290                 295                 300                 


Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala Leu 
            340                 345                 350         


Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Lys His His His His His His 
    370                 375                 380         


<210>  189
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5-6GS-C5-6GS-C5

<400>  189

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val 
        35                  40                  45              


Ser Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser 
    130                 135                 140                 


Leu Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His Ala 
145                 150                 155                 160 


Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ser 
                165                 170                 175     


Cys Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Leu Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gln Val 
                245                 250                 255     


Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu 
            260                 265                 270         


Thr Leu Ser Cys Val Ala Ser Gly Val Thr Leu Gly Arg His Ala Ile 
        275                 280                 285             


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Arg Val Ser Cys 
    290                 295                 300                 


Ile Arg Thr Phe Asp Gly Ile Thr Ser Tyr Val Glu Ser Thr Lys Gly 
305                 310                 315                 320 


Arg Phe Thr Ile Ser Ser Asn Asn Ala Met Asn Thr Val Tyr Leu Gln 
                325                 330                 335     


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala Leu 
            340                 345                 350         


Gly Val Thr Ala Ala Cys Ser Asp Asn Pro Tyr Phe Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser 
    370                 375 


<210>  190
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_A10 CDR1

<400>  190

Gly Arg Thr Phe Ser Thr Thr Arg 
1               5               


<210>  191
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_A10 CDR2

<400>  191

Ile Phe Leu Asn Thr Gly Thr Thr 
1               5               


<210>  192
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_A10 CDR3

<400>  192

Ala Ala Gly Arg Phe Ser Ala Ala Pro Leu Thr Gln Ser Thr Ala Phe 
1               5                   10                  15      


Glu Ser 
        


<210>  193
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_D10 CDR1

<400>  193

Gly Arg Thr Ser Ser Asp Tyr Ser 
1               5               


<210>  194
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_D10 CDR2

<400>  194

Leu Ala Trp Thr Val Gly Ala Thr 
1               5               


<210>  195
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_D10 CDR3

<400>  195

Ala Gly Arg Tyr Gly Ala Gly Leu Gly Phe Thr Glu Arg Ile Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  196
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8 CDR1

<400>  196

Gly Gly Thr Phe Ser Thr Ala Ala 
1               5               


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8 CDR2

<400>  197

Ile Gly Trp Arg Gly Val Arg Thr 
1               5               


<210>  198
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8 CDR3

<400>  198

Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro Trp Ala His Phe Glu Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3_C5 CDR1

<400>  199

Gly Arg Thr Leu Ser Met Arg 
1               5           


<210>  200
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3_C5 CDR2

<400>  200

Ile Asn Trp Ser Ser Gly Ser Ile 
1               5               


<210>  201
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3_C5 CDR3

<400>  201

Ala Val Gln Val Asp Ile Gly Gly Tyr Leu Asp Gly Tyr Asp Tyr 
1               5                   10                  15  


<210>  202
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8_G11 CDR1

<400>  202

Gly Arg Thr Ile Thr Glu Tyr Thr 
1               5               


<210>  203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8_G11 CDR2

<400>  203

Ile Ser Lys Ser Thr Asp Ser Thr 
1               5               


<210>  204
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8_G11 CDR3

<400>  204

Ala Ala Gly Ser Phe Tyr Gly Arg Asp Ser Asp Ala Gly Gly Tyr Asp 
1               5                   10                  15      


Tyr 
    


<210>  205
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12_F11 CDR1

<400>  205

Gly Gly Ala Phe Ser Thr Ser Ala 
1               5               


<210>  206
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12_F11 CDR2

<400>  206

Ile Gly Trp Arg Gly Val Arg Thr 
1               5               


<210>  207
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12_F11 CDR3

<400>  207

Ala Ala Ser Asp Gly Asn Tyr Gly Leu Pro Trp Ala His Phe Glu Tyr 
1               5                   10                  15      


Asp Phe 
        


<210>  208
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbSA_A10

<400>  208
caggtgcagc tggtcgagtc tgggggaggc ttggtgcagg ctggggactc tctgagactc       60

tcctgtgcag cctctggacg taccttcagt accactcgca tggcctggtt ccgccagcct      120

ccagggaagg agcgcgagtt tgtagcggcg atttttctga atactggcac gacatactat      180

gcagatcccg tgaaggaccg attcgccatc tccagagaca atgccaaaaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgcgc agcgggtcgg      300

ttcagcgctg ctccgcttac acagtcaact gcctttgagt cctggggcca ggggacccag      360

gtcaccgtct cc                                                          372


<210>  209
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_A10

<400>  209

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Thr 
            20                  25                  30          


Arg Met Ala Trp Phe Arg Gln Pro Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Phe Leu Asn Thr Gly Thr Thr Tyr Tyr Ala Asp Pro Val 
    50                  55                  60                  


Lys Asp Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ser Ala Ala Pro Leu Thr Gln Ser Thr Ala Phe 
            100                 105                 110         


Glu Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ala 
        115                 120                 125 


<210>  210
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NbSA_D10

<400>  210
caggtgcagc tggtcgagtc tgggggagga ttggtacagg ttgggggctc tctgagactc       60

tcctgtgcag tctctggacg caccagcagt gactattccg tgggctggtt ccgccgggct      120

caagggaagg agcgtgagtt tgtggctgct ctggcgtgga ctgttggcgc cacacactat      180

ggagactccg tgaagggccg attcaccgtc tccagagaca acgccaagaa catggtgtat      240

ctgcaaatag acagcctgaa acctgaagac acgggcgttt attactgtgc aggtcgatat      300

ggagcgggat tggggttcac cgaaagaatc tatgactact ggggccaggg gacccaggtc      360

accgtttcct ca                                                          372


<210>  211
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NbSA_D10

<400>  211

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Arg Thr Ser Ser Asp Tyr 
            20                  25                  30          


Ser Val Gly Trp Phe Arg Arg Ala Gln Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Leu Ala Trp Thr Val Gly Ala Thr His Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gly Arg Tyr Gly Ala Gly Leu Gly Phe Thr Glu Arg Ile Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  212
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A8

<400>  212
caggtgcagc tggtcgagtc tgggggagga ttggtgcagg ctggaggctc tctgagactc       60

tcctgtgcag cctctggagg caccttcagt accgctgcca tgggctggtt ccgccaggct      120

ccaggcgagg agcgtgagtg tgtagcatct ataggctgga gaggtgttag aacatggtat      180

gcagactccg tgaagggccg atttaccatc tccagagata atccccagaa tacggtgtat      240

ttgcagatga acaacctgaa atctggcgac acggccgttt attactgcgc agcctcagtc      300

ggcaactacg ggttgccgtg ggcccacttc gaatatgact tctggggcca ggggatccag      360

gtcaccgtgt cgtca                                                       375


<210>  213
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A8

<400>  213

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ser Ile Gly Trp Arg Gly Val Arg Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro Trp Ala His Phe Glu Tyr 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  214
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3_C5

<400>  214
cagccggcca tggcccaggt gcagctggtc gagtctgggg gaggattggt gcaggctggg       60

ggctccctga gactctcctg tgcagcctct ggacgcacct tgagtatgcg tcgcatgagc      120

tggttccgcc aggctccagg gaaggagcgt gagtttgtag ccactattaa ctggagtagt      180

ggtagtatat acgttacaga ctccgtgaag gaccgattca ccatctccag agacaacgcc      240

gagaacacgg tgcatctgca aatgaacatg ctgaaacctg aggacacggc cgtttattcg      300

tgtgcagtcc aagtcgatat tggggggtac ctcgacggct atgactactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


<210>  215
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3_C5

<400>  215

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Leu Ser Met Arg 
            20                  25                  30          


Arg Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Asn Trp Ser Ser Gly Ser Ile Tyr Val Thr Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Val His 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Val Gln Val Asp Ile Gly Gly Tyr Leu Asp Gly Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  216
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8_G11

<400>  216
caggtgcagc tggtcgagtc tgggggagga ttggtgcagg ctgggggctc tctgagactc       60

tcctgtgcag cctctggacg caccatcact gaatatacca tagggtggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtaacactt attagcaaga gtactgatag tacatgggat      180

gcagactccg tgaagggccg attcaccatc gccagagatt acgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac acggccgttt attactgtgc agctggctcc      300

ttttacgggc gcgattcgga tgctgggggc tatgactact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  217
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8_G11

<400>  217

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ile Thr Glu Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Thr Leu Ile Ser Lys Ser Thr Asp Ser Thr Trp Asp Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Tyr Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Phe Tyr Gly Arg Asp Ser Asp Ala Gly Gly Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  218
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12_F11

<400>  218
caggtgcagc tggtcgagtc tggaggagga ttggtgcagg ctggaggctc tctgagactc       60

tcctgtgcag cctctggagg cgccttcagt acctctgcca tgggctggtt ccgccaggct      120

ccagggaagg aacgtgagtt tgtcgcagtt ataggctgga gaggtgttag aacatactat      180

gcagactccg tgaagggccg tttcaccatc gccagagata atccccagaa cagggtgtat      240

ctggagatga gcagcctgaa atctgacgac acgggcgttt atttctgtgc agcctcagac      300

ggcaactacg gattgccgtg ggcccatttc gagtatgact tctggggcca ggggatccag      360

gtcaccgtct cctca                                                       375


<210>  219
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12_F11

<400>  219

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ala Phe Ser Thr Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Val Ile Gly Trp Arg Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Pro Gln Asn Arg Val Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Lys Ser Asp Asp Thr Gly Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Ser Asp Gly Asn Tyr Gly Leu Pro Trp Ala His Phe Glu Tyr 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Ile Gln Val Thr Ser Ser 
        115                 120                 


<210>  220
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C1 alternative sequence (N76Q),

<400>  220

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp Phe Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  221
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent A8

<400>  221

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ser Ile Gly Trp Arg Gly Val Arg Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro Trp Ala His Phe Glu Tyr 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe 
145                 150                 155                 160 


Ser Thr Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg 
                165                 170                 175     


Glu Cys Val Ala Ser Ile Gly Trp Arg Gly Val Arg Thr Trp Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Gln Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Ser Gly Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro Trp Ala His 
225                 230                 235                 240 


Phe Glu Tyr Asp Phe Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            260                 265                 270         


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        275                 280                 285             


Gly Thr Phe Ser Thr Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
    290                 295                 300                 


Glu Glu Arg Glu Cys Val Ala Ser Ile Gly Trp Arg Gly Val Arg Thr 
305                 310                 315                 320 


Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Pro Gln Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Ser Gly Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro 
        355                 360                 365             


Trp Ala His Phe Glu Tyr Asp Phe Trp Gly Gln Gly Thr Gln Val Thr 
    370                 375                 380                 


Val Ser Ser Lys His His His His His His 
385                 390                 


<210>  222
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent A8

<400>  222

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Ser Thr Ala 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg Glu Cys Val 
        35                  40                  45              


Ala Ser Ile Gly Trp Arg Gly Val Arg Thr Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Lys Ser Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro Trp Ala His Phe Glu Tyr 
            100                 105                 110         


Asp Phe Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe 
145                 150                 155                 160 


Ser Thr Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Glu Glu Arg 
                165                 170                 175     


Glu Cys Val Ala Ser Ile Gly Trp Arg Gly Val Arg Thr Trp Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Gln Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Ser Gly Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro Trp Ala His 
225                 230                 235                 240 


Phe Glu Tyr Asp Phe Trp Gly Gln Gly Ile Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            260                 265                 270         


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        275                 280                 285             


Gly Thr Phe Ser Thr Ala Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
    290                 295                 300                 


Glu Glu Arg Glu Cys Val Ala Ser Ile Gly Trp Arg Gly Val Arg Thr 
305                 310                 315                 320 


Trp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Pro Gln Asn Thr Val Tyr Leu Gln Met Asn Asn Leu Lys Ser Gly Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Ala Ser Val Gly Asn Tyr Gly Leu Pro 
        355                 360                 365             


Trp Ala His Phe Glu Tyr Asp Phe Trp Gly Gln Gly Ile Gln Val Thr 
    370                 375                 380                 


Val Ser Ser 
385         


<210>  223
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Trivalent C1

<400>  223
caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc       60

tcctgtgcag cctctggatt cactaatgat ttttatagca tcgcgtggtt ccgccaggcc      120

ccaggaaagg agcgtgaggg ggtctcatgg cttagtgtca gtgataatac cccaacctac      180

gtagactccg tgaaggaccg gttcaccatc tccagacaca acgccaacaa caccgtgtac      240

ctgcaaatga acatgctgaa acctgaggac acggccattt actattgtgc agcaggacgc      300

ttcgcgggaa gggatacttg gccctcgtcc tatgattact ggggccaggg gacccaggtc      360

accgtctcct cagggagcgg ttctggctcc caggtgcagc tggtggagtc tgggggaggc      420

ttggtgcagc ctgggggctc tctgagactc tcctgtgcag cctctggatt cactaatgat      480

ttttatagca tcgcgtggtt ccgccaggcc ccaggaaagg agcgtgaggg ggtctcatgg      540

cttagtgtca gtgataatac cccaacctac gtagactccg tgaaggaccg gttcaccatc      600

tccagacaca acgccaacaa caccgtgtac ctgcaaatga acatgctgaa acctgaggac      660

acggccattt actattgtgc agcaggacgc ttcgcgggaa gggatacttg gccctcgtcc      720

tatgattact ggggccaggg gacccaggtc accgtctcct cagggagcgg ttctggctcc      780

caggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctgggggctc tctgagactc      840

tcctgtgcag cctctggatt cactaatgat ttttatagca tcgcgtggtt ccgccaggcc      900

ccaggaaagg agcgtgaggg ggtctcatgg cttagtgtca gtgataatac cccaacctac      960

gtagactccg tgaaggaccg gttcaccatc tccagacaca acgccaacaa caccgtgtac     1020

ctgcaaatga acatgctgaa acctgaggac acggccattt actattgtgc agcaggacgc     1080

ttcgcgggaa gggatacttg gccctcgtcc tatgattact ggggccaggg gacccaggtc     1140

accgtctcct ca                                                         1152


<210>  224
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent C1

<400>  224

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp Phe Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Gln Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp 
145                 150                 155                 160 


Phe Tyr Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     


Gly Val Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp 
            180                 185                 190         


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Gln Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser 
225                 230                 235                 240 


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
                245                 250                 255     


Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        275                 280                 285             


Asn Asp Phe Tyr Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Gly Val Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr 
305                 310                 315                 320 


Val Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Gln 
                325                 330                 335     


Asn Thr Val Tyr Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala 
            340                 345                 350         


Ile Tyr Tyr Cys Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro 
        355                 360                 365             


Ser Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    370                 375                 380                 


<210>  225
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent C1

<400>  225

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp Phe Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Asn Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly Ser 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Asn Asp 
145                 150                 155                 160 


Phe Tyr Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     


Gly Val Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr Val Asp 
            180                 185                 190         


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Asn Asn Thr 
        195                 200                 205             


Val Tyr Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala Ile Tyr 
    210                 215                 220                 


Tyr Cys Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro Ser Ser 
225                 230                 235                 240 


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
                245                 250                 255     


Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        275                 280                 285             


Asn Asp Phe Tyr Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Gly Val Ser Trp Leu Ser Val Ser Asp Asn Thr Pro Thr Tyr 
305                 310                 315                 320 


Val Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg His Asn Ala Asn 
                325                 330                 335     


Asn Thr Val Tyr Leu Gln Met Asn Met Leu Lys Pro Glu Asp Thr Ala 
            340                 345                 350         


Ile Tyr Tyr Cys Ala Ala Gly Arg Phe Ala Gly Arg Asp Thr Trp Pro 
        355                 360                 365             


Ser Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    370                 375                 380                 


<210>  226
<211>  1197
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Trivalent F2

<400>  226
caggtgcagc tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctaagactc       60

gcttgtatag cctctggacg caccttccat agctatgtca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attagttgga gtagtacacc gacatactat      180

ggagaatccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga accgcctgaa acctgaggac acggccgttt atttctgtgc agcagaccgg      300

ggtgaaagtt actactacac tcgacccacc gagtatgaat tctggggcca ggggacccag      360

gtcaccgtct cctcagggag cggttctggc tccgggagcg gttctggctc ccaggtgcag      420

ctggtggagt ctgggggagg attggtgcag gctgggggct ctctaagact cgcttgtata      480

gcctctggac gcaccttcca tagctatgtc atggcctggt tccgccaggc tccagggaag      540

gagcgtgagt ttgtagcagc tattagttgg agtagtacac cgacatacta tggagaatcc      600

gtgaagggcc gattcaccat ctccagagac aacgccaaga acacggtgta tctgcaaatg      660

aaccgcctga aacctgagga cacggccgtt tatttctgtg cagcagaccg gggtgaaagt      720

tactactaca ctcgacccac cgagtatgaa ttctggggcc aggggaccca ggtcaccgtc      780

tcctcaggga gcggttctgg ctccgggagc ggttctggct cccaggtgca gctggtggag      840

tctgggggag gattggtgca ggctgggggc tctctaagac tcgcttgtat agcctctgga      900

cgcaccttcc atagctatgt catggcctgg ttccgccagg ctccagggaa ggagcgtgag      960

tttgtagcag ctattagttg gagtagtaca ccgacatact atggagaatc cgtgaagggc     1020

cgattcacca tctccagaga caacgccaag aacacggtgt atctgcaaat gaaccgcctg     1080

aaacctgagg acacggccgt ttatttctgt gcagcagacc ggggtgaaag ttactactac     1140

actcgaccca ccgagtatga attctggggc caggggaccc aggtcaccgt ctcctca        1197


<210>  227
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent F2

<400>  227

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ile Ala Ser Gly Arg Thr Phe His Ser Tyr 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Ser Thr Pro Thr Tyr Tyr Gly Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Glu Ser Tyr Tyr Tyr Thr Arg Pro Thr Glu Tyr 
            100                 105                 110         


Glu Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Ser Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ala Cys Ile 
145                 150                 155                 160 


Ala Ser Gly Arg Thr Phe His Ser Tyr Val Met Ala Trp Phe Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp Ser Ser 
            180                 185                 190         


Thr Pro Thr Tyr Tyr Gly Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Arg Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Phe Cys Ala Ala Asp Arg Gly Glu Ser 
225                 230                 235                 240 


Tyr Tyr Tyr Thr Arg Pro Thr Glu Tyr Glu Phe Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
            260                 265                 270         


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala 
        275                 280                 285             


Gly Gly Ser Leu Arg Leu Ala Cys Ile Ala Ser Gly Arg Thr Phe His 
    290                 295                 300                 


Ser Tyr Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
305                 310                 315                 320 


Phe Val Ala Ala Ile Ser Trp Ser Ser Thr Pro Thr Tyr Tyr Gly Glu 
                325                 330                 335     


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
            340                 345                 350         


Val Tyr Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr 
        355                 360                 365             


Phe Cys Ala Ala Asp Arg Gly Glu Ser Tyr Tyr Tyr Thr Arg Pro Thr 
    370                 375                 380                 


Glu Tyr Glu Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 


<210>  228
<211>  1179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Trivalent H3

<400>  228
caggtgcagc tggtggagtc tgggggagga ttggtgaaga ctgggggctc tctgagactc       60

tcctgtgcag cctctggccg caccttcagt acctacagca tgggctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcaggt atgcgctgga cgggtagtag tacattctac      180

tcagactccg tgaagggccg attcaccgtc tccagaaaca acgccaagga cacggtgtat      240

ctgcacatga acagcctgaa acctgaggac acggccgttt attactgtgc aatcacgact      300

atcgtaagag cttactatac tgagtatacc gaagctgact ttggttcctg gggccagggg      360

acccaggtca ccgtctcctc gggagcggtt ctggctccac aggtgcagct ggtggagtct      420

gggggaggat tggtgaagac tgggggctct ctgagactct cctgtgcagc ctctggccgc      480

accttcagta cctacagcat gggctggttc cgccaggctc cagggaagga gcgtgagttt      540

gtagcaggta tgcgctggac gggtagtagt acattctact cagactccgt gaagggccga      600

ttcaccgtct ccagaaacaa cgccaaggac acggtgtatc tgcacatgaa cagcctgaaa      660

cctgaggaca cggccgttta ttactgtgca atcacgacta tcgtaagagc ttactatact      720

gagtataccg aagctgactt tggttcctgg ggccagggga cccaggtcac cgtctcctca      780

gggagcggtt ctggctccca ggtgcagctg gtggagtctg ggggaggatt ggtgaagact      840

gggggctctc tgagactctc ctgtgcagcc tctggccgca ccttcagtac ctacagcatg      900

ggctggttcc gccaggctcc agggaaggag cgtgagtttg tagcaggtat gcgctggacg      960

ggtagtagta cattctactc agactccgtg aagggccgat tcaccgtctc cagaaacaac     1020

gccaaggaca cggtgtatct gcacatgaac agcctgaaac ctgaggacac ggccgtttat     1080

tactgtgcaa tcacgactat cgtaagagct tactatactg agtataccga agctgacttt     1140

ggttcctggg gccaggggac ccaggtcacc gtctcctca                            1179


<210>  229
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent H3

<400>  229

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Met Arg Trp Thr Gly Ser Ser Thr Phe Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asn Asn Ala Lys Asp Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Thr Thr Ile Val Arg Ala Tyr Tyr Thr Glu Tyr Thr Glu Ala 
            100                 105                 110         


Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        115                 120                 125             


Ala Val Leu Ala Pro Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Lys Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Phe Ser Thr Tyr Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ala Gly Met Arg Trp Thr Gly Ser Ser Thr Phe 
            180                 185                 190         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asn Asn Ala 
        195                 200                 205             


Lys Asp Thr Val Tyr Leu His Met Asn Ser Leu Lys Pro Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ile Thr Thr Ile Val Arg Ala Tyr Tyr Thr 
225                 230                 235                 240 


Glu Tyr Thr Glu Ala Asp Phe Gly Ser Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu 
            260                 265                 270         


Ser Gly Gly Gly Leu Val Lys Thr Gly Gly Ser Leu Arg Leu Ser Cys 
        275                 280                 285             


Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr Ser Met Gly Trp Phe Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Gly Met Arg Trp Thr 
305                 310                 315                 320 


Gly Ser Ser Thr Phe Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Val 
                325                 330                 335     


Ser Arg Asn Asn Ala Lys Asp Thr Val Tyr Leu His Met Asn Ser Leu 
            340                 345                 350         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ile Thr Thr Ile Val 
        355                 360                 365             


Arg Ala Tyr Tyr Thr Glu Tyr Thr Glu Ala Asp Phe Gly Ser Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390             


<210>  230
<211>  1086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Trivalent A8

<400>  230
ggaggcacct tcagtaccgc tgccatgggc tggttccgcc aggctccagg cgaggagcgt       60

gagtgtgtag catctatagg ctggagaggt gttagaacat ggtatgcaga ctccgtgaag      120

ggccgattta ccatctccag agataatccc cagaatacgg tgtatttgca gatgaacaac      180

ctgaaatctg gcgacacggc cgtttattac tgcgcagcct cagtcggcaa ctacgggttg      240

ccgtgggccc acttcgaata tgacttctgg ggccagggga tccaggtcac cgtgtcgtca      300

gggagcggtt ctggctccca ggtgcagctg gtcgagtctg ggggaggatt ggtgcaggct      360

ggaggctctc tgagactctc ctgtgcagcc tctggaggca ccttcagtac cgctgccatg      420

ggctggttcc gccaggctcc aggcgaggag cgtgagtgtg tagcatctat aggctggaga      480

ggtgttagaa catggtatgc agactccgtg aagggccgat ttaccatctc cagagataat      540

ccccagaata cggtgtattt gcagatgaac aacctgaaat ctggcgacac ggccgtttat      600

tactgcgcag cctcagtcgg caactacggg ttgccgtggg cccacttcga atatgacttc      660

tggggccagg ggatccaggt caccgtgtcg tcagggagcg gttctggctc ccaggtgcag      720

ctggtcgagt ctgggggagg attggtgcag gctggaggct ctctgagact ctcctgtgca      780

gcctctggag gcaccttcag taccgctgcc atgggctggt tccgccaggc tccaggcgag      840

gagcgtgagt gtgtagcatc tataggctgg agaggtgtta gaacatggta tgcagactcc      900

gtgaagggcc gatttaccat ctccagagat aatccccaga atacggtgta tttgcagatg      960

aacaacctga aatctggcga cacggccgtt tattactgcg cagcctcagt cggcaactac     1020

gggttgccgt gggcccactt cgaatatgac ttctggggcc aggggatcca ggtcaccgtg     1080

tcgtca                                                                1086


<210>  231
<211>  1273
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus

<400>  231

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  232
<211>  160
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus

<400>  232

Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys 
1               5                   10                  15      


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe 
            20                  25                  30          


Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr 
        35                  40                  45              


Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln 
    50                  55                  60                  


Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
65                  70                  75                  80  


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
                85                  90                  95      


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
            100                 105                 110         


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
        115                 120                 125             


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
    130                 135                 140                 


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr 
145                 150                 155                 160 


<210>  233
<211>  152
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus

<400>  233

Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
1               5                   10                  15      


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
            20                  25                  30          


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
        35                  40                  45              


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
    50                  55                  60                  


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
65                  70                  75                  80  


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
                85                  90                  95      


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
            100                 105                 110         


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
        115                 120                 125             


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
    130                 135                 140                 


Val Leu Ser Phe Glu Leu Leu His 
145                 150         


<210>  234
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH_72-SUMO-C5

<400>  234

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Ser Gly Gly Ser Thr Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Gly Leu Gly Thr Val Val Ser Glu Trp Asp Tyr Asp Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys 
    130                 135                 140                 


Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly 
145                 150                 155                 160 


Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg 
                165                 170                 175     


Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu 
            180                 185                 190         


Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu 
        195                 200                 205             


Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln 
    210                 215                 220                 


Ile Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
225                 230                 235                 240 


Gly Ser Val Gln Ala Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser 
                245                 250                 255     


Gly Val Thr Leu Gly Arg His Ala Ile Gly Trp Phe Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Glu Arg Glu Arg Val Ser Cys Ile Arg Thr Phe Asp Gly Ile 
        275                 280                 285             


Thr Ser Tyr Val Glu Ser Thr Lys Gly Arg Phe Thr Ile Ser Ser Asn 
    290                 295                 300                 


Asn Ala Met Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
305                 310                 315                 320 


Asp Thr Ala Val Tyr Phe Cys Ala Leu Gly Val Thr Ala Ala Cys Ser 
                325                 330                 335     


Asp Asn Pro Tyr Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            340                 345                 350         


<210>  235
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH_H6 CDR1

<400>  235

Glu Ser Ser Leu Ala Pro Tyr Arg 
1               5               


<210>  236
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH_H6 CDR2

<400>  236

Ile Ser Arg Asp Ala His Pro Thr Ser Thr 
1               5                   10  


<210>  237
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH_H6 CDR3

<400>  237

Ala Thr Asp Leu Gly Gly Tyr Cys Ser Asp Ser Asn Tyr Pro Arg Ala 
1               5                   10                  15      


Trp 
    


<210>  238
<211>  378
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VHH_H6

<400>  238
caggtgcagc tggtcgagtc tgggggaggc ttggtgcagc ctggggggtc tctgacactc       60

tcctgtgtag cgtcggaatc atctttggcg ccttatcgcg tagcctggtt ccgtcaggcc      120

ccagggaagg agcgcgaggg ggtctcatgt attagtcgtg atgcacatcc tactagtaca      180

tactatacag cctccgtgaa gggccgattc accatgtcca gagacaatgc caagaacacg      240

gtgtatctgc aaatgaacag cctgaaacca tcggacacgg ccgtttatta ctgtgcgaca      300

gatttgggag gatactgttc ggattctaat tatccccgcg cctggtgggg ccaggggacc      360

caggtcaccg tctcctca                                                    378


<210>  239
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH_H6

<400>  239

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Val Ala Ser Glu Ser Ser Leu Ala Pro Tyr 
            20                  25                  30          


Arg Val Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Arg Asp Ala His Pro Thr Ser Thr Tyr Tyr Thr Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Met Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Ser Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Asp Leu Gly Gly Tyr Cys Ser Asp Ser Asn Tyr Pro 
            100                 105                 110         


Arg Ala Trp Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  240
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  240

Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 
1               5                   10                  15      


Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 
            20                  25                  30          


Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys 
        35                  40                  45              


Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe 
    50                  55                  60                  


Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 
65                  70                  75                  80  


Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 
                85                  90                  95      


Gly His Ser Thr Val 
            100     


<210>  241
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  241

Met Ser Asp Gln Asp Ser Ser Glu Ile His Phe Lys Val Lys Met Thr 
1               5                   10                  15      


Thr His Leu Lys Lys Leu Lys Glu Ser Tyr Cys Gln Arg Gln Gly Val 
            20                  25                  30          


Pro Met Asn Ser Leu Arg Phe Leu Phe Glu Gly Gln Arg Ile Ala Asp 
        35                  40                  45              


Asn His Thr Pro Lys Glu Leu Gly Met Glu Glu Glu Asp Val Ile Glu 
    50                  55                  60                  


Val Tyr Gln Glu Gln Thr Gly Gly His Ser Thr Val 
65                  70                  75      


<210>  242
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  242

Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly 
    50                  55                  60                  


Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Tyr 
                85                  90                  95  


<210>  243
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  243

Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Leu Glu Met Glu Asp Glu Asp Thr Ile Asp Val Phe Gln 
    50                  55                  60                  


Gln Gln Thr Gly Gly Val Tyr 
65                  70      


<210>  244
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  244

Met Ser Glu Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asp His 
1               5                   10                  15      


Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe Lys 
            20                  25                  30          


Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys Glu 
        35                  40                  45              


Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly Gln 
    50                  55                  60                  


Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp Glu 
65                  70                  75                  80  


Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Pro Glu Ser 
                85                  90                  95      


Ser Leu Ala Gly His Ser Phe 
            100             


<210>  245
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  245

Gln Val Arg His Leu Ala Pro Pro Gln Ser Leu Pro Val Cys Ala Leu 
1               5                   10                  15      


Val Leu Cys Val Pro Gly Ile Pro Arg Ala Arg Ala Ser Arg Gly Trp 
            20                  25                  30          


Thr Gln Met Gln Leu Pro Glu 
        35                  


<210>  246
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  246

Met Ala Asn Glu Lys Pro Thr Glu Glu Val Lys Thr Glu Asn Asn Asn 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg Gln Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Pro Arg Gly Leu Ser Met Lys Gln Ile Arg Phe Arg Phe Gly Gly 
    50                  55                  60                  


Gln Pro Ile Ser Gly Thr Asp Lys Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Pro Thr Gly Gly Val Tyr 
                85                  90                  95  


<210>  247
<211>  1776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F2-GSGSGS-SUMO-GSGSGS-VHH_H6

<400>  247
caggtgcagc tggtggagtc tgggggagga ttggtgcagg ctgggggctc tctaagactc       60

gcttgtatag cctctggacg caccttccat agctatgtca tggcctggtt ccgccaggct      120

ccagggaagg agcgtgagtt tgtagcagct attagttgga gtagtacacc gacatactat      180

ggagaatccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtat      240

ctgcaaatga accgcctgaa acctgaggac acggccgttt atttctgtgc agcagaccgg      300

ggtgaaagtt actactacac tcgacccacc gagtatgaat tctggggcca ggggacccag      360

gtcaccgtct cctcagggag cggttctggc tccgatagcg aagtgaacca ggaagcgaaa      420

ccggaagtta aaccggaagt gaaaccggaa acccatatta atctgaaagt tagcgacggc      480

agcagcgaaa tcttttttaa aattaaaaaa accaccccgc tgcgtcgcct gatggaagcc      540

tttgcgaaac gtcagggtaa agaaatggat agcctgcgct ttctgtatga cggcatccgt      600

attcaggccg atcagacccc ggaagacctg gatatggaag acaacgatat tattgaagcg      660

catcgcgaac agatcggctc aggtagcggg tcgcaggtgc agctggtcga gtctggggga      720

ggcttggtgc agcctggggg gtctctgaca ctctcctgtg tagcgtcgga atcatctttg      780

gcgccttatc gcgtagcctg gttccgtcag gccccaggga aggagcgcga gggggtctca      840

tgtattagtc gtgatgcaca tcctactagt acatactata cagcctccgt gaagggccga      900

ttcaccatgt ccagagacaa tgccaagaac acggtgtatc tgcaaatgaa cagcctgaaa      960

ccatcggaca cggccgttta ttactgtgcg acagatttgg gaggatactg ttcggattct     1020

aattatcccc gcgcctggtg gggccagggg acccaggtca ccgtctcctc agcgtcgacc     1080

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg     1140

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1200

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1260

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1320

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1380

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1440

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1500

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1560

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1620

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc     1680

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1740

tacacgcaga agagcctctc cctgtccccg ggtaaa                               1776


<210>  248
<211>  592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2-GSGSGS-SUMO-GSGSGS-VHH_H6

<400>  248

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ile Ala Ser Gly Arg Thr Phe His Ser Tyr 
            20                  25                  30          


Val Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Ser Thr Pro Thr Tyr Tyr Gly Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ala Asp Arg Gly Glu Ser Tyr Tyr Tyr Thr Arg Pro Thr Glu Tyr 
            100                 105                 110         


Glu Phe Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Gly 
        115                 120                 125             


Ser Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys 
    130                 135                 140                 


Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly 
145                 150                 155                 160 


Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg 
                165                 170                 175     


Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu 
            180                 185                 190         


Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu 
        195                 200                 205             


Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln 
    210                 215                 220                 


Ile Gly Ser Gly Ser Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
225                 230                 235                 240 


Gly Leu Val Gln Pro Gly Gly Ser Leu Thr Leu Ser Cys Val Ala Ser 
                245                 250                 255     


Glu Ser Ser Leu Ala Pro Tyr Arg Val Ala Trp Phe Arg Gln Ala Pro 
            260                 265                 270         


Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Ser Arg Asp Ala His Pro 
        275                 280                 285             


Thr Ser Thr Tyr Tyr Thr Ala Ser Val Lys Gly Arg Phe Thr Met Ser 
    290                 295                 300                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
305                 310                 315                 320 


Pro Ser Asp Thr Ala Val Tyr Tyr Cys Ala Thr Asp Leu Gly Gly Tyr 
                325                 330                 335     


Cys Ser Asp Ser Asn Tyr Pro Arg Ala Trp Trp Gly Gln Gly Thr Gln 
            340                 345                 350         


Val Thr Val Ser Ser Ala Ser Thr Glu Pro Lys Ser Cys Asp Lys Thr 
        355                 360                 365             


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
    370                 375                 380                 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
385                 390                 395                 400 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
                405                 410                 415     


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
            420                 425                 430         


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
        435                 440                 445             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    450                 455                 460                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
465                 470                 475                 480 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                485                 490                 495     


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            500                 505                 510         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        515                 520                 525             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    530                 535                 540                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
545                 550                 555                 560 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                565                 570                 575     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            580                 585                 590         


