﻿                         序列表

<110>  广东菲鹏生物有限公司

<120>  HCV重组抗原及其突变体

<150>  CN202010976432.1
<151>  2020-09-16

<160>  19

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  583
<212>  PRT
<213>  HCV

<400>  1
Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr Leu 
1               5                   10                  15      
Ala Gly Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp Gln 
            20                  25                  30          
Asp Leu Val Gly Trp His Arg Pro Pro Gly Ala Arg Ser Leu Thr Pro 
        35                  40                  45              
Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
    50                  55                  60                  
Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
65                  70                  75                  80  
Pro Arg Pro Val Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
                85                  90                  95      
Cys Pro Phe Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr 
            100                 105                 110         
Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Thr Met Glu 
        115                 120                 125             
Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala 
    130                 135                 140                 
Val Pro Gln Thr Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser 
145                 150                 155                 160 
Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys 
                165                 170                 175     
Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala 
            180                 185                 190         
Tyr Met Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg Thr Gly Val 
        195                 200                 205             
Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr Tyr Gly Lys 
    210                 215                 220                 
Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile 
225                 230                 235                 240 
Cys Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile Leu Gly Ile Gly 
                245                 250                 255     
Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu 
            260                 265                 270         
Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile 
        275                 280                 285             
Glu Glu Val Ala Leu Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys 
    290                 295                 300                 
Ala Ile Pro Ile Glu Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys 
305                 310                 315                 320 
His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Ser Leu 
                325                 330                 335     
Gly Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile 
            340                 345                 350         
Pro Ser Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr 
        355                 360                 365             
Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val 
    370                 375                 380                 
Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr 
385                 390                 395                 400 
Thr Thr Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg 
                405                 410                 415     
Thr Gly Arg Gly Arg Glu Gly Ile Tyr Arg Phe Val Thr Pro Gly Glu 
            420                 425                 430         
Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp 
        435                 440                 445             
Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg 
    450                 455                 460                 
Leu Arg Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His 
465                 470                 475                 480 
Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala 
                485                 490                 495     
His Phe Leu Ser Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr Leu 
            500                 505                 510         
Val Ala Tyr Gln Ala Thr Val Cys Ala Lys Ala Gln Ala Pro Pro Pro 
        515                 520                 525             
Ser Trp Asp Gln Met Trp Lys Cys Leu Thr Arg Leu Lys Pro Thr Leu 
    530                 535                 540                 
Gln Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu 
545                 550                 555                 560 
Val Thr Leu Thr His Pro Ile Thr Lys Tyr Ile Met Thr Cys Met Ser 
                565                 570                 575     
Ala Asp Leu Glu Val Val Thr 
            580             

<210>  2
<211>  417
<212>  PRT
<213>  HCV

<400>  2
Ala Val Asp Phe Ile Pro Val Glu Thr Met Glu Thr Thr Met Arg Ser 
1               5                   10                  15      
Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Pro Gln Thr Phe 
            20                  25                  30          
Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys 
        35                  40                  45              
Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn 
    50                  55                  60                  
Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala 
65                  70                  75                  80  
His Gly Val Asp Pro Asn Ile Arg Thr Gly Val Arg Thr Ile Thr Thr 
                85                  90                  95      
Gly Ala Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly 
            100                 105                 110         
Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His 
        115                 120                 125             
Ser Thr Asp Ser Thr Thr Ile Leu Gly Ile Gly Thr Val Leu Asp Gln 
    130                 135                 140                 
Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala Thr Ala Thr Pro 
145                 150                 155                 160 
Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu Glu Val Ala Leu 
                165                 170                 175     
Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile Pro Ile Glu 
            180                 185                 190         
Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys 
        195                 200                 205             
Cys Asp Glu Leu Ala Ala Lys Leu Ser Ser Leu Gly Leu Asn Ala Val 
    210                 215                 220                 
Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Ser Ser Gly Asp 
225                 230                 235                 240 
Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp 
                245                 250                 255     
Phe Asp Ser Val Ile Asp Cys Asn Thr Ala Val Thr Gln Thr Val Asp 
            260                 265                 270         
Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr Val Pro Gln 
        275                 280                 285             
Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg Thr Gly Arg Gly Arg 
    290                 295                 300                 
Glu Gly Ile Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly Met 
305                 310                 315                 320 
Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly Cys Ala Trp 
                325                 330                 335     
Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg Leu Arg Ala Tyr Leu 
            340                 345                 350         
Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His Leu Glu Phe Trp Glu 
        355                 360                 365             
Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala His Phe Leu Ser Gln 
    370                 375                 380                 
Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr Leu Val Ala Tyr Gln Ala 
385                 390                 395                 400 
Thr Val Cys Ala Lys Ala Gln Ala Pro Pro Pro Ser Trp Asp Gln Met 
                405                 410                 415     
Trp 
    

<210>  3
<211>  326
<212>  PRT
<213>  HCV

<400>  3
Ala Val Asp Phe Ile Pro Val Glu Thr Met Glu Thr Thr Met Arg Ser 
1               5                   10                  15      
Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Pro Gln Thr Phe 
            20                  25                  30          
Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys 
        35                  40                  45              
Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn 
    50                  55                  60                  
Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala 
65                  70                  75                  80  
His Gly Val Asp Pro Asn Ile Arg Thr Gly Val Arg Thr Ile Thr Thr 
                85                  90                  95      
Gly Ala Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly 
            100                 105                 110         
Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His 
        115                 120                 125             
Ser Thr Asp Ser Thr Thr Ile Leu Gly Ile Gly Thr Val Leu Asp Gln 
    130                 135                 140                 
Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala Thr Ala Thr Pro 
145                 150                 155                 160 
Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu Glu Val Ala Leu 
                165                 170                 175     
Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile Pro Ile Glu 
            180                 185                 190         
Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys 
        195                 200                 205             
Cys Asp Glu Leu Ala Ala Lys Leu Ser Ser Leu Gly Leu Asn Ala Val 
    210                 215                 220                 
Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Ser Ser Gly Asp 
225                 230                 235                 240 
Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp 
                245                 250                 255     
Phe Asp Ser Val Ile Asp Cys Asn Thr Ala Val Thr Gln Thr Val Asp 
            260                 265                 270         
Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr Val Pro Gln 
        275                 280                 285             
Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg Thr Gly Arg Gly Arg 
    290                 295                 300                 
Glu Gly Ile Tyr Arg Phe Val Thr Pro Gly Glu Arg Pro Ser Gly Met 
305                 310                 315                 320 
Phe Asp Ser Ser Val Leu 
                325     

<210>  4
<211>  287
<212>  PRT
<213>  HCV

<400>  4
Ala Val Asp Phe Ile Pro Val Glu Thr Met Glu Thr Thr Met Arg Ser 
1               5                   10                  15      
Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val Pro Gln Thr Phe 
            20                  25                  30          
Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys 
        35                  40                  45              
Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val Leu Val Leu Asn 
    50                  55                  60                  
Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala 
65                  70                  75                  80  
His Gly Val Asp Pro Asn Ile Arg Thr Gly Val Arg Thr Ile Thr Thr 
                85                  90                  95      
Gly Ala Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly 
            100                 105                 110         
Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys Asp Glu Cys His 
        115                 120                 125             
Ser Thr Asp Ser Thr Thr Ile Leu Gly Ile Gly Thr Val Leu Asp Gln 
    130                 135                 140                 
Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala Thr Ala Thr Pro 
145                 150                 155                 160 
Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu Glu Val Ala Leu 
                165                 170                 175     
Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile Pro Ile Glu 
            180                 185                 190         
Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys His Ser Lys Lys Lys 
        195                 200                 205             
Cys Asp Glu Leu Ala Ala Lys Leu Ser Ser Leu Gly Leu Asn Ala Val 
    210                 215                 220                 
Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Ser Ser Gly Asp 
225                 230                 235                 240 
Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly Phe Thr Gly Asp 
                245                 250                 255     
Phe Asp Ser Val Ile Asp Cys Asn Thr Ala Val Thr Gln Thr Val Asp 
            260                 265                 270         
Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr Thr Thr Val Pro 
        275                 280                 285         

<210>  5
<211>  236
<212>  PRT
<213>  HCV

<400>  5
Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala 
1               5                   10                  15      
Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr 
            20                  25                  30          
Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala His Gly Val Asp Pro Asn 
        35                  40                  45              
Ile Arg Thr Gly Val Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr 
    50                  55                  60                  
Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala 
65                  70                  75                  80  
Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ser Thr Thr 
                85                  90                  95      
Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala 
            100                 105                 110         
Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val 
        115                 120                 125             
Pro His Pro Asn Ile Glu Glu Val Ala Leu Ser Asn Thr Gly Glu Ile 
    130                 135                 140                 
Pro Phe Tyr Gly Lys Ala Ile Pro Ile Glu Ala Ile Arg Gly Gly Arg 
145                 150                 155                 160 
His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala 
                165                 170                 175     
Lys Leu Ser Ser Leu Gly Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu 
            180                 185                 190         
Asp Val Ser Val Ile Pro Ser Ser Gly Asp Val Val Val Val Ala Thr 
        195                 200                 205             
Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp 
    210                 215                 220                 
Cys Asn Thr Ala Val Thr Gln Thr Val Asp Phe Ser 
225                 230                 235     

<210>  6
<211>  631
<212>  PRT
<213>  HCV

<400>  6
Ala Pro Ile Thr Ala Tyr Ser Gln Gln Thr Arg Gly Leu Leu Gly Cys 
1               5                   10                  15      
Ile Ile Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu Gly Glu 
            20                  25                  30          
Val Gln Val Val Ser Thr Ala Thr Gln Ser Phe Leu Ala Thr Cys Ile 
        35                  40                  45              
Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Ser Lys Thr Leu 
    50                  55                  60                  
Ala Gly Pro Lys Gly Pro Ile Thr Gln Met Tyr Thr Asn Val Asp Gln 
65                  70                  75                  80  
Asp Leu Val Gly Trp His Arg Pro Pro Gly Ala Arg Ser Leu Thr Pro 
                85                  90                  95      
Cys Thr Cys Gly Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp 
            100                 105                 110         
Val Ile Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser 
        115                 120                 125             
Pro Arg Pro Val Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu 
    130                 135                 140                 
Cys Pro Phe Gly His Val Ala Gly Ile Phe Arg Ala Ala Val Cys Thr 
145                 150                 155                 160 
Arg Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Thr Met Glu 
                165                 170                 175     
Thr Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala 
            180                 185                 190         
Val Pro Gln Thr Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser 
        195                 200                 205             
Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys 
    210                 215                 220                 
Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala 
225                 230                 235                 240 
Tyr Met Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg Thr Gly Val 
                245                 250                 255     
Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr Tyr Gly Lys 
            260                 265                 270         
Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile 
        275                 280                 285             
Cys Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile Leu Gly Ile Gly 
    290                 295                 300                 
Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu 
305                 310                 315                 320 
Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile 
                325                 330                 335     
Glu Glu Val Ala Leu Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys 
            340                 345                 350         
Ala Ile Pro Ile Glu Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys 
        355                 360                 365             
His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Ser Leu 
    370                 375                 380                 
Gly Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile 
385                 390                 395                 400 
Pro Ser Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr 
                405                 410                 415     
Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val 
            420                 425                 430         
Thr Gln Thr Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile Glu Thr 
        435                 440                 445             
Thr Thr Val Pro Gln Asp Ala Val Ser Arg Ser Gln Arg Arg Gly Arg 
    450                 455                 460                 
Thr Gly Arg Gly Arg Glu Gly Ile Tyr Arg Phe Val Thr Pro Gly Glu 
465                 470                 475                 480 
Arg Pro Ser Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp 
                485                 490                 495     
Ala Gly Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg 
            500                 505                 510         
Leu Arg Ala Tyr Leu Asn Thr Pro Gly Leu Pro Val Cys Gln Asp His 
        515                 520                 525             
Leu Glu Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile Asp Ala 
    530                 535                 540                 
His Phe Leu Ser Gln Thr Lys Gln Ala Gly Asp Asn Phe Pro Tyr Leu 
545                 550                 555                 560 
Val Ala Tyr Gln Ala Thr Val Cys Ala Lys Ala Gln Ala Pro Pro Pro 
                565                 570                 575     
Ser Trp Asp Gln Met Trp Lys Cys Leu Thr Arg Leu Lys Pro Thr Leu 
            580                 585                 590         
Gln Gly Pro Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu 
        595                 600                 605             
Val Thr Leu Thr His Pro Ile Thr Lys Tyr Ile Met Thr Cys Met Ser 
    610                 615                 620                 
Ala Asp Leu Glu Val Val Thr 
625                 630     

<210>  7
<211>  41
<212>  PRT
<213>  HCV

<400>  7
Ile Pro Ile Glu Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys His 
1               5                   10                  15      
Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Ser Leu Gly 
            20                  25                  30          
Leu Asn Ala Val Ala Tyr Tyr Arg Gly 
        35                  40      

<210>  8
<211>  236
<212>  PRT
<213>  HCV

<400>  8
Ala Pro Thr Gly Ser Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala 
1               5                   10                  15      
Ala Gln Gly Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr 
            20                  25                  30          
Leu Gly Phe Gly Ala Tyr Met Ser Lys Ala His Gly Val Asp Pro Asn 
        35                  40                  45              
Ile Arg Thr Gly Val Arg Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr 
    50                  55                  60                  
Ser Thr Tyr Gly Lys Phe Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala 
65                  70                  75                  80  
Tyr Asp Ile Ile Ile Cys Asp Glu Cys His Ser Thr Asp Ser Thr Thr 
                85                  90                  95      
Ile Leu Gly Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala 
            100                 105                 110         
Arg Leu Val Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr Val 
        115                 120                 125             
Pro His Pro Asn Ile Glu Glu Val Ala Leu Ser Asn Thr Gly Glu Ile 
    130                 135                 140                 
Pro Phe Tyr Gly Lys Ala Ile Pro Ile Glu Ala Ile Arg Gly Gly Arg 
145                 150                 155                 160 
His Leu Ile Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala 
                165                 170                 175     
Lys Leu Ser Ser Leu Gly Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu 
            180                 185                 190         
Asp Val Ser Val Ile Pro Ser Ser Gly Asp Val Val Val Val Ala Thr 
        195                 200                 205             
Asp Ala Leu Met Thr Gly Phe Thr Gly Asp Phe Asp Ser Val Ile Asp 
    210                 215                 220                 
Cys Asn Thr Cys Val Thr Gln Thr Val Asp Phe Ser 
225                 230                 235     

<210>  9
<211>  67
<212>  PRT
<213>  HCV

<400>  9
Gly Lys Ala Ile Pro Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile 
1               5                   10                  15      
Phe Cys His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val 
            20                  25                  30          
Ala Leu Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser 
        35                  40                  45              
Val Ile Pro Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu 
    50                  55                  60                  
Met Thr Gly 
65          

<210>  10
<211>  109
<212>  PRT
<213>  Artificial

<400>  10
Met Ser Asp Lys Ile Ile His Leu Thr Asp Asp Ser Phe Asp Thr Asp 
1               5                   10                  15      
Val Leu Lys Ala Asp Gly Ala Ile Leu Val Asp Phe Trp Ala Glu Trp 
            20                  25                  30          
Cys Gly Pro Cys Lys Met Ile Ala Pro Ile Leu Asp Glu Ile Ala Asp 
        35                  40                  45              
Glu Tyr Gln Gly Lys Leu Thr Val Ala Lys Leu Asn Ile Asp Gln Asn 
    50                  55                  60                  
Pro Gly Thr Ala Pro Lys Tyr Gly Ile Arg Gly Ile Pro Thr Leu Leu 
65                  70                  75                  80  
Leu Phe Lys Asn Gly Glu Val Ala Ala Thr Lys Val Gly Ala Leu Ser 
                85                  90                  95      
Lys Gly Gln Leu Lys Glu Phe Leu Asp Ala Asn Leu Ala 
            100                 105                 

<210>  11
<211>  59
<212>  PRT
<213>  HCV

<400>  11
Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr Arg Glu Phe Asp 
1               5                   10                  15      
Glu Met Glu Glu Cys Ser Gln His Leu Pro Tyr Ile Glu Gln Gly Met 
            20                  25                  30          
Met Leu Ala Glu Gln Phe Lys Gln Lys Ala Leu Gly Leu Leu Gln Thr 
        35                  40                  45              
Ala Thr Lys Gln Ala Glu Ala Ala Ala Pro Val 
    50                  55                  

<210>  12
<211>  47
<212>  PRT
<213>  HCV

<400>  12
Gly Gly Lys Pro Ala Leu Val Pro Asp Lys Glu Val Leu Tyr Gln Gln 
1               5                   10                  15      
Tyr Asp Glu Met Glu Glu Cys Ser Gln Ala Ala Pro Tyr Ile Glu Gln 
            20                  25                  30          
Ala Gln Val Ile Ala His Gln Phe Lys Glu Lys Val Leu Gly Leu 
        35                  40                  45          

<210>  13
<211>  48
<212>  PRT
<213>  HCV

<400>  13
Asn Asp Gln Val Val Val Thr Pro Asp Lys Glu Ile Leu Tyr Glu Ala 
1               5                   10                  15      
Phe Asp Glu Met Glu Glu Cys Ala Ser Lys Ala Ala Leu Ile Glu Glu 
            20                  25                  30          
Gly Gln Arg Met Ala Glu Met Leu Lys Ser Lys Ile Gln Gly Leu Leu 
        35                  40                  45              

<210>  14
<211>  234
<212>  PRT
<213>  HCV

<400>  14
Arg Glu Val Leu Tyr Arg Glu Phe Asp Glu Met Glu Glu Cys Ser Gln 
1               5                   10                  15      
His Leu Pro Tyr Ile Glu Gln Gly Met Met Leu Ala Glu Gln Phe Lys 
            20                  25                  30          
Gln Lys Ala Leu Gly Leu Leu Gln Thr Ala Ser Arg Gln Ala Glu Ala 
        35                  40                  45              
Thr Ala Pro Val Val Gln Ser Lys Trp Gln Ser Leu Glu Thr Phe Trp 
    50                  55                  60                  
Ala Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu Ala Gly 
65                  70                  75                  80  
Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met Ala Phe 
                85                  90                  95      
Thr Ala Ala Val Thr Ser Pro Phe Ser Thr Gln Gln Thr Leu Leu Phe 
            100                 105                 110         
Asn Ile Leu Gly Gly Trp Val Ala Ala Gln Leu Ala Ala Pro Ser Ala 
        115                 120                 125             
Ala Thr Ser Phe Val Gly Ala Gly Ile Ala Gly Ala Ala Ile Gly Ser 
    130                 135                 140                 
Val Gly Leu Gly Lys Val Leu Val Asp Ile Leu Ala Gly Tyr Gly Ala 
145                 150                 155                 160 
Gly Val Ala Gly Ala Leu Val Ala Phe Lys Val Met Ser Gly Glu Val 
                165                 170                 175     
Pro Thr Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile Leu Ser Pro 
            180                 185                 190         
Gly Ala Leu Val Val Gly Val Val Cys Ala Ala Ile Leu Arg Arg His 
        195                 200                 205             
Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu Ile Ala 
    210                 215                 220                 
Phe Ala Ser Arg Gly Asn His Val Ser Pro 
225                 230                 

<210>  15
<211>  109
<212>  PRT
<213>  HCV

<400>  15
Lys Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr Arg Glu Phe Asp 
1               5                   10                  15      
Glu Met Glu Glu Cys Ser Gln His Leu Pro Tyr Ile Glu Gln Gly Met 
            20                  25                  30          
Met Leu Ala Glu Gln Phe Lys Gln Lys Ala Leu Gly Leu Leu Gln Thr 
        35                  40                  45              
Ala Ser Arg Gln Ala Glu Ala Thr Ala Pro Val Val Gln Ser Lys Trp 
    50                  55                  60                  
Gln Ser Leu Glu Thr Phe Trp Ala Lys His Met Trp Asn Phe Ile Ser 
65                  70                  75                  80  
Gly Ile Gln Tyr Leu Ala Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala 
                85                  90                  95      
Ile Ala Ser Leu Met Ala Phe Thr Ala Ala Val Thr Ser 
            100                 105                 

<210>  16
<211>  80
<212>  PRT
<213>  HCV

<400>  16
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asp 
1               5                   10                  15      
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  
Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  

<210>  17
<211>  53
<212>  PRT
<213>  HCV

<400>  17
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asp 
1               5                   10                  15      
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              
Thr Arg Lys Thr Ser 
    50              

<210>  18
<211>  48
<212>  PRT
<213>  HCV

<400>  18
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asp 
1               5                   10                  15      
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              

<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<400>  19
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

