                         SEQUENCE LISTING

<110>  ݿҽҩƼ޹˾
             Ƿ
 
<120>  ܹڱԴٲ塢Ƽ;

<130>  UP-213420-5952

<150>  CN2020109739442

<151>  2020-09-16

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  367
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  1
gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct       60

cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt      120

gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg      180

gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta      240

acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac      300

ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc      360

ttggtta                                                                367


<210>  2
<211>  1014
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  2
atgagacata ttatctgcca cggaggtgtt attaccgaag aaatggccgc cagtcttttg       60

gaccagctga tcgaagaggt actggctgat aatcttccac ctcctagcca ttttgaacca      120

cctacccttc acgaactgta tgatttagac gtgacggccc ccgaagatcc caacgaggag      180

gcggtttcgc agatttttcc cgactctgta atgttggcgg tgcaggaagg gattgactta      240

ctcacttttc cgccggcgcc cggttctccg gagccgcctc acctttcccg gcagcccgag      300

cagccggagc agagagcctt gggtccggtt tctatgccaa accttgtacc ggaggtgatc      360

gatccaccca gtgacgacga ggatgaagag ggtgaggagt ttgtgttaga ttatgtggag      420

caccccgggc acggttgcag gtcttgtcat tatcaccgga ggaatacggg ggacccagat      480

attatgtgtt cgctttgcta tatgaggacc tgtggcatgt ttgtctacag tcctgtgtct      540

gaacctgagc ctgagcccga gccagaaccg gagcctgcaa gacctacccg ccgtcctaaa      600

atggcgcctg ctatcctgag acgcccgaca tcacctgtgt ctagagaatg caatagtagt      660

acggatagct gtgactccgg tccttctaac acacctcctg agatacaccc ggtggtcccg      720

ctgtgcccca ttaaaccagt tgccgtgaga gttggtgggc gtcgccaggc tgtggaatgt      780

atcgaggact tgcttaacga gcctgggcaa cctttggact tgagctgtaa acgccccagg      840

ccataaggtg taaacctgtg attgcgtgtg tggttaacgc ctttgtttgc tgaatgagtt      900

gatgtaagtt taataaaggg tgagataatg tttaacttgc atggcgtgtt aaatggggcg      960

gggcttaaag ggtatataat gcgccgtggg ctaatcttgg ttacatctga cctc           1014


<210>  3
<211>  1796
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  3
atggaggctt gggagtgttt ggaagatttt tctgctgtgc gtaacttgct ggaacagagc       60

tctaacagta cctcttggtt ttggaggttt ctgtggggct catcccaggc aaagttagtc      120

tgcagaatta aggaggatta caagtgggaa tttgaagagc ttttgaaatc ctgtggtgag      180

ctgtttgatt ctttgaatct gggtcaccag gcgcttttcc aagagaaggt catcaagact      240

ttggattttt ccacaccggg gcgcgctgcg gctgctgttg cttttttgag ttttataaag      300

gataaatgga gcgaagaaac ccatctgagc ggggggtacc tgctggattt tctggccatg      360

catctgtgga gagcggttgt gagacacaag aatcgcctgc tactgttgtc ttccgtccgc      420

ccggcgataa taccgacgga ggagcagcag cagcagcagg aggaagccag gcggcggcgg      480

caggagcaga gcccatggaa cccgagagcc ggcctggacc ctcgggaatg aatgttgtac      540

aggtggctga actgtatcca gaactgagac gcattttgac aattacagag gatgggcagg      600

ggctaaaggg ggtaaagagg gagcgggggg cttgtgaggc tacagaggag gctaggaatc      660

tagcttttag cttaatgacc agacaccgtc ctgagtgtat tacttttcaa cagatcaagg      720

ataattgcgc taatgagctt gatctgctgg cgcagaagta ttccatagag cagctgacca      780

cttactggct gcagccaggg gatgattttg aggaggctat tagggtatat gcaaaggtgg      840

cacttaggcc agattgcaag tacaagatca gcaaacttgt aaatatcagg aattgttgct      900

acatttctgg gaacggggcc gaggtggaga tagatacgga ggatagggtg gcctttagat      960

gtagcatgat aaatatgtgg ccgggggtgc ttggcatgga cggggtggtt attatgaatg     1020

taaggtttac tggccccaat tttagcggta cggttttcct ggccaatacc aaccttatcc     1080

tacacggtgt aagcttctat gggtttaaca atacctgtgt ggaagcctgg accgatgtaa     1140

gggttcgggg ctgtgccttt tactgctgct ggaagggggt ggtgtgtcgc cccaaaagca     1200

gggcttcaat taagaaatgc ctctttgaaa ggtgtacctt gggtatcctg tctgagggta     1260

actccagggt gcgccacaat gtggcctccg actgtggttg cttcatgcta gtgaaaagcg     1320

tggctgtgat taagcataac atggtatgtg gcaactgcga ggacagggcc tctcagatgc     1380

tgacctgctc ggacggcaac tgtcacctgc tgaagaccat tcacgtagcc agccactctc     1440

gcaaggcctg gccagtgttt gagcataaca tactgacccg ctgttccttg catttgggta     1500

acaggagggg ggtgttccta ccttaccaat gcaatttgag tcacactaag atattgcttg     1560

agcccgagag catgtccaag gtgaacctga acggggtgtt tgacatgacc atgaagatct     1620

ggaaggtgct gaggtacgat gagacccgca ccaggtgcag accctgcgag tgtggcggta     1680

aacatattag gaaccagcct gtgatgctgg atgtgaccga ggagctgagg cccgatcact     1740

tggtgctggc ctgcacccgc gctgagtttg gctctagcga tgaagataca gattga         1796


<210>  4
<211>  10
<212>  DNA
<213>  ˹Уartificial sequence


<220>
<221>  misc_feature
<222>  (4)
<223>  r Ϊ a  g

<400>  4
gccrccatgg                                                              10


<210>  5
<211>  870
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  5
atgagacata ttatctgcca cggaggtgtt attaccgaag aaatggccgc cagtcttttg       60

gaccagctga tcgaagaggt actggctgat aatcttccac ctcctagcca ttttgaacca      120

cctacccttc acgaactgta tgatttagac gtgacggccc ccgaagatcc caacgaggag      180

gcggtttcgc agatttttcc cgactctgta atgttggcgg tgcaggaagg gattgactta      240

ctcacttttc cgccggcgcc cggttctccg gagccgcctc acctttcccg gcagcccgag      300

cagccggagc agagagcctt gggtccggtt tctatgccaa accttgtacc ggaggtgatc      360

gatcttacct gccacgaggc tggctttcca cccagtgacg acgaggatga agagggtgag      420

gagtttgtgt tagattatgt ggagcacccc gggcacggtt gcaggtcttg tcattatcac      480

cggaggaata cgggggaccc agatattatg tgttcgcttt gctatatgag gacctgtggc      540

atgtttgtct acagtcctgt gtctgaacct gagcctgagc ccgagccaga accggagcct      600

gcaagaccta cccgccgtcc taaaatggcg cctgctatcc tgagacgccc gacatcacct      660

gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct      720

cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt      780

gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg      840

gacttgagct gtaaacgccc caggccataa                                       870


<210>  6
<211>  289
<212>  PRT
<213>  ˹Уartificial sequence

<400>  6

Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 
1               5                   10                  15      


Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 
            20                  25                  30          


Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 
        35                  40                  45              


Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 
    50                  55                  60                  


Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 
65                  70                  75                  80  


Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 
                85                  90                  95      


Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 
            100                 105                 110         


Pro Asn Leu Val Pro Glu Val Ile Asp Val Thr Ser His Asp Ala Gly 
        115                 120                 125             


Phe Pro Pro Ser Asp Asp Glu Asp Glu Glu Gly Glu Glu Phe Val Leu 
    130                 135                 140                 


Asp Tyr Val Glu His Pro Gly His Gly Cys Arg Ser Cys His Tyr His 
145                 150                 155                 160 


Arg Arg Asn Thr Gly Asp Pro Asp Ile Met Cys Ser Leu Cys Tyr Met 
                165                 170                 175     


Arg Thr Cys Gly Met Phe Val Tyr Ser Pro Val Ser Glu Pro Glu Pro 
            180                 185                 190         


Glu Pro Glu Pro Glu Pro Glu Pro Ala Arg Pro Thr Arg Arg Pro Lys 
        195                 200                 205             


Met Ala Pro Ala Ile Leu Arg Arg Pro Thr Ser Pro Val Ser Arg Glu 
    210                 215                 220                 


Cys Asn Ser Ser Thr Asp Ser Cys Asp Ser Gly Pro Ser Asn Thr Pro 
225                 230                 235                 240 


Pro Glu Ile His Pro Val Val Pro Leu Cys Pro Ile Lys Pro Val Ala 
                245                 250                 255     


Val Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu 
            260                 265                 270         


Leu Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg 
        275                 280                 285             


Pro 
    


<210>  7
<211>  24
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  7
cttacctgcc acgaggctgg cttt                                              24


<210>  8
<211>  499
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  8
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt      120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg      180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag      240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga      300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg      360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc      420

cgggtcaaag ttggcgtttt attattatag tcagctgacg tgtagtgtat ttatacccgg      480

tgagttcctc aagaggcca                                                   499


<210>  9
<211>  184
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  9
cgtggagact cgcccaggtg tttttctcag gtgttttccg cgttccgggt caaagttggc       60

gttttattat tatagtcagc tgacgtgtag tgtatttata cccggtgagt tcctcaagag      120

gccactcttg agtgccagcg agtagagttt tctcctccga gccgctccga caccgggact      180

gaaa                                                                   184


<210>  10
<211>  9
<212>  PRT
<213>  ˹Уartificial sequence

<400>  10

Ser Leu Leu Met Trp Ile Thr Gln Cys 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  ˹Уartificial sequence

<400>  11

Gly Ala Asp Gly Val Gly Lys Ser Ala 
1               5                   


<210>  12
<211>  365
<212>  PRT
<213>  ˣHomo sapiens

<400>  12

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  13
<211>  366
<212>  PRT
<213>  ˹Уartificial sequence

<400>  13

Met Ala Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Gln Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asn Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Lys Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Lys Thr Leu Gln Arg Ala Glu His 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Gly Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Met Ala Val Val Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Ser Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Ala 
        355                 360                 365     


<210>  14
<211>  22
<212>  PRT
<213>  ˣHomo sapiens

<400>  14

Met Lys Gly Ser Ile Phe Thr Leu Phe Leu Phe Ser Val Leu Phe Ala 
1               5                   10                  15      


Ile Ser Glu Val Arg Ser 
            20          


<210>  15
<211>  462
<212>  PRT
<213>  ˹Уartificial sequence

<400>  15

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val Arg Ala Lys 
        355                 360                 365             


Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu 
    370                 375                 380                 


Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Lys Gly 
385                 390                 395                 400 


Ser Ile Phe Thr Leu Phe Leu Phe Ser Val Leu Phe Ala Ile Ser Glu 
                405                 410                 415     


Val Arg Ser Ser Leu Leu Met Trp Ile Thr Gln Cys Arg Arg Lys Arg 
            420                 425                 430         


Ser Leu Leu Met Trp Ile Thr Gln Cys Arg Arg Lys Arg Ser Leu Leu 
        435                 440                 445             


Met Trp Ile Thr Gln Cys Arg Arg Arg Arg Lys Asp Glu Leu 
    450                 455                 460         


<210>  16
<211>  467
<212>  PRT
<213>  ˹Уartificial sequence

<400>  16

Met Ala Val Met Ala Pro Arg Thr Leu Ile Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Gln Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Lys Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asn Gln Phe Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Lys Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Lys Thr Leu Gln Arg Ala Glu His 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Glu Pro Leu Thr Leu Arg Trp Gly Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Met Ala Val Val Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Ser Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Ala Arg Ala 
        355                 360                 365             


Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp 
    370                 375                 380                 


Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Lys 
385                 390                 395                 400 


Gly Ser Ile Phe Thr Leu Phe Leu Phe Ser Val Leu Phe Ala Ile Ser 
                405                 410                 415     


Glu Val Arg Ser Gly Ala Asp Gly Val Gly Lys Ser Ala Arg Arg Lys 
            420                 425                 430         


Arg Arg Arg Lys Arg Gly Ala Asp Gly Val Gly Lys Ser Ala Arg Arg 
        435                 440                 445             


Lys Arg Gly Ala Asp Gly Val Gly Lys Ser Ala Arg Arg Lys Arg Lys 
    450                 455                 460                 


Asp Glu Leu 
465         


<210>  17
<211>  119
<212>  PRT
<213>  ˣHomo sapiens

<400>  17

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  18
<211>  1824
<212>  DNA
<213>  ˹Уartificial sequence

<400>  18
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg atctgagaaa tgtgactcca      420

cccaaggtct ccttgtttga gccatcaaaa gcagagattg caaacaaaca aaaggctacc      480

ctcgtgtgct tggccagggg cttcttccct gaccacgtgg agctgagctg gtgggtgaat      540

ggcaaggagg tccacagtgg ggtcagcacg gaccctcagg cctacaagga gagcaattat      600

agctactgcc tgagcagccg cctgagggtc tctgctacct tctggcacaa tcctcgcaac      660

cacttccgct gccaagtgca gttccatggg ctttcagagg aggacaagtg gccagagggc      720

tcacccaaac ctgtcacaca gaacatcagt gcagaggcct ggggccgagc agactgtggg      780

attacctcag catcctatca acaaggggtc ttgtctgcca ccatcctcta tgagatcctg      840

ctagggaaag ccaccctgta tgctgtgctt gtcagtacac tggtggtgat ggctatggtc      900

aaaagaaaga attcacgtgc caagcgatcc ggaagcggag cccctgtaaa gcagactttg      960

aattttgacc ttctcaagtt ggcgggagac gtcgagtcca accctgggcc catggagacc     1020

ctcttgggcc tgcttatcct ttggctgcag ctgcaatggg tgagcagcaa acaggaggtg     1080

acacagattc ctgcagctct gagtgtccca gaaggagaaa acttggttct caactgcagt     1140

ttcactgata gcgctattta caacctccag tggtttaggc aggaccctgg gaaaggtctc     1200

acatctctgt tgcttattca gtcaagtcag agagagcaaa caagtggaag acttaatgcc     1260

tcgctggata aatcatcagg acgtagtact ttatacattg cagcttctca gcctggtgac     1320

tcagccacct acctctgtgc tgtgaggccc ctgtacggag gaagctacat acctacattt     1380

ggaagaggaa ccagccttat tgttcatccg tatatccaga acccagaacc tgctgtgtac     1440

cagttaaaag atcctcggtc tcaggacagc accctctgcc tgttcaccga ctttgactcc     1500

caaatcaatg tgccgaaaac catggaatct ggaacgttca tcactgacaa aactgtgctg     1560

gacatgaaag ctatggattc caagagcaat ggggccattg cctggagcaa ccagacaagc     1620

ttcacctgcc aagatatctt caaagagacc aacgccacct accccagttc agacgttccc     1680

tgtgatgcca cgttgaccga gaaaagcttt gaaacagata tgaacctaaa ctttcaaaac     1740

ctgtcagtta tgggactccg aatcctcctg ctgaaagtag cgggatttaa cctgctcatg     1800

acgctgaggc tgtggtccag ttga                                            1824


<210>  19
<211>  1824
<212>  DNA
<213>  ˹Уartificial sequence

<400>  19
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttgct gaaggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg atctgagaaa tgtgactcca      420

cccaaggtct ccttgtttga gccatcaaaa gcagagattg caaacaaaca aaaggctacc      480

ctcgtgtgct tggccagggg cttcttccct gaccacgtgg agctgagctg gtgggtgaat      540

ggcaaggagg tccacagtgg ggtcagcacg gaccctcagg cctacaagga gagcaattat      600

agctactgcc tgagcagccg cctgagggtc tctgctacct tctggcacaa tcctcgcaac      660

cacttccgct gccaagtgca gttccatggg ctttcagagg aggacaagtg gccagagggc      720

tcacccaaac ctgtcacaca gaacatcagt gcagaggcct ggggccgagc agactgtggg      780

attacctcag catcctatca acaaggggtc ttgtctgcca ccatcctcta tgagatcctg      840

ctagggaaag ccaccctgta tgctgtgctt gtcagtacac tggtggtgat ggctatggtc      900

aaaagaaaga attcacgtgc caagcgatcc ggaagcggag cccctgtaaa gcagactttg      960

aattttgacc ttctcaagtt ggcgggagac gtcgagtcca accctgggcc catggagacc     1020

ctcttgggcc tgcttatcct ttggctgcag ctgcaatggg tgagcagcaa acaggaggtg     1080

acacagattc ctgcagctct gagtgtccca gaaggagaaa acttggttct caactgcagt     1140

ttcactgata gcgctattta caacctccag tggtttaggc aggaccctgg gaaaggtctc     1200

acatctctgt tgcttattca gtcaagtcag agagagcaaa caagtggaag acttaatgcc     1260

tcgctggata aatcatcagg acgtagtact ttatacattg cagcttctca gcctggtgac     1320

tcagccacct acctctgtgc tgtgaggccc acatcaggag gaagctacat acctacattt     1380

ggaagaggaa ccagccttat tgttcatccg tatatccaga acccagaacc tgctgtgtac     1440

cagttaaaag atcctcggtc tcaggacagc accctctgcc tgttcaccga ctttgactcc     1500

caaatcaatg tgccgaaaac catggaatct ggaacgttca tcactgacaa aactgtgctg     1560

gacatgaaag ctatggattc caagagcaat ggggccattg cctggagcaa ccagacaagc     1620

ttcacctgcc aagatatctt caaagagacc aacgccacct accccagttc agacgttccc     1680

tgtgatgcca cgttgaccga gaaaagcttt gaaacagata tgaacctaaa ctttcaaaac     1740

ctgtcagtta tgggactccg aatcctcctg ctgaaagtag cgggatttaa cctgctcatg     1800

acgctgaggc tgtggtccag ttga                                            1824


<210>  20
<211>  1809
<212>  DNA
<213>  ˹Уartificial sequence

<400>  20
atgggctcct ggaccctctg ctgtgtgtcc ctttgcatcc tggtagcaaa gcacacagat       60

gctggagtta tccagtcacc ccggcacgag gtgacagaga tgggacaaga agtgactctg      120

agatgtaaac caatttcagg acacgactac cttttctggt acagacagac catgatgcgg      180

ggactggagt tgctcattta ctttaacaac aacgttccga tagatgattc agggatgccc      240

gaggatcgat tctcagctaa gatgcctaat gcatcattct ccactctgaa gatccagccc      300

tcagaaccca gggactcagc tgtgtacttc tgtgccagca gtttaggctc caacgagcag      360

tacttcgggc cgggcaccag gctcacggtc acagaggatc tgagaaatgt gactccaccc      420

aaggtctcct tgtttgagcc atcaaaagca gagattgcaa acaaacaaaa ggctaccctc      480

gtgtgcttgg ccaggggctt cttccctgac cacgtggagc tgagctggtg ggtgaatggc      540

aaggaggtcc acagtggggt cagcacggac cctcaggcct acaaggagag caattatagc      600

tactgcctga gcagccgcct gagggtctct gctaccttct ggcacaatcc tcgcaaccac      660

ttccgctgcc aagtgcagtt ccatgggctt tcagaggagg acaagtggcc agagggctca      720

cccaaacctg tcacacagaa catcagtgca gaggcctggg gccgagcaga ctgtgggatt      780

acctcagcat cctatcaaca aggggtcttg tctgccacca tcctctatga gatcctgcta      840

gggaaagcca ccctgtatgc tgtgcttgtc agtacactgg tggtgatggc tatggtcaaa      900

agaaagaatt cacgtgccaa gcgatccgga agcggagccc ctgtaaagca gactttgaat      960

tttgaccttc tcaagttggc gggagacgtc gagtccaacc ctgggcccat ggaaactctc     1020

ctgggagtgt ctttggtgat tctatggctt caactggcta gggtgaacag tcaacaggga     1080

gaagaggatc ctcaggcctt gagcatccag gagggtgaaa atgccaccat gaactgcagt     1140

tacaaaacta gtataaacaa tttacagtgg tatagacaaa attcaggtag aggccttgtc     1200

cacctaattt taatacgttc aaatgaaaga gagaaacaca gtggaagatt aagagtcacg     1260

cttgacactt ccaagaaaag cagttccttg ttgatcacgg cttcccgggc agcagacact     1320

gcttcttact tctgtatgta cgaccagaac ggcaagatca tctttggaaa agggacacga     1380

cttcatattc tccccaatat ccagaaccca gaacctgctg tgtaccagtt aaaagatcct     1440

cggtctcagg acagcaccct ctgcctgttc accgactttg actcccaaat caatgtgccg     1500

aaaaccatgg aatctggaac gttcatcact gacaaaactg tgctggacat gaaagctatg     1560

gattccaaga gcaatggggc cattgcctgg agcaaccaga caagcttcac ctgccaagat     1620

atcttcaaag agaccaacgc cacctacccc agttcagacg ttccctgtga tgccacgttg     1680

accgagaaaa gctttgaaac agatatgaac ctaaactttc aaaacctgtc agttatggga     1740

ctccgaatcc tcctgctgaa agtagcggga tttaacctgc tcatgacgct gaggctgtgg     1800

tccagttga                                                             1809


<210>  21
<211>  1812
<212>  DNA
<213>  ˹Уartificial sequence

<400>  21
atgggccccg ggctcctctg ctgggcactg ctttgtctcc tgggagcagg cttagtggac       60

gctggagtca cccaaagtcc cacacacctg atcaaaacga gaggacagca agtgactctg      120

agatgctctc ctaagtctgg gcatgacact gtgtcctggt accaacaggc cctgggtcag      180

gggccccagt ttatctttca gtattatgag gaggaagaga gacagagagg caacttccct      240

gatcgattct caggtcacca gttccctaac tatagctctg agctgaatgt gaacgccttg      300

ttgctggggg actcggccct ctatctctgt gccagcagct tgggtgaggg aagagtggac      360

ggctacacct tcggttcggg gaccaggtta accgttgtag aggatctgag aaatgtgact      420

ccacccaagg tctccttgtt tgagccatca aaagcagaga ttgcaaacaa acaaaaggct      480

accctcgtgt gcttggccag gggcttcttc cctgaccacg tggagctgag ctggtgggtg      540

aatggcaagg aggtccacag tggggtcagc acggaccctc aggcctacaa ggagagcaat      600

tatagctact gcctgagcag ccgcctgagg gtctctgcta ccttctggca caatcctcgc      660

aaccacttcc gctgccaagt gcagttccat gggctttcag aggaggacaa gtggccagag      720

ggctcaccca aacctgtcac acagaacatc agtgcagagg cctggggccg agcagactgt      780

gggattacct cagcatccta tcaacaaggg gtcttgtctg ccaccatcct ctatgagatc      840

ctgctaggga aagccaccct gtatgctgtg cttgtcagta cactggtggt gatggctatg      900

gtcaaaagaa agaattcacg tgccaagcga tccggaagcg gagcccctgt aaagcagact      960

ttgaattttg accttctcaa gttggcggga gacgtcgagt ccaaccctgg gcccatgagg     1020

caagtggcga gagtgatcgt gttcctgacc ctgagtactt tgagccttgc taagaccacc     1080

cagcccatct ccatggactc atatgaagga caagaagtga acataacctg tagccacaac     1140

aacattgcta caaatgatta tatcacgtgg taccaacagt ttcccagcca aggaccacga     1200

tttattattc aaggatacaa gacaaaagtt acaaacgaag tggcctccct gtttatccct     1260

gccgacagaa agtccagcac tctgagcctg ccccgggttt ccctgagcga cactgctgtg     1320

tactactgcc tcgtgggtga catggatcag gcaggaactg ctctgatctt tgggaaggga     1380

accaccttat cagtgagttc catccagaac ccagaacctg ctgtgtacca gttaaaagat     1440

cctcggtctc aggacagcac cctctgcctg ttcaccgact ttgactccca aatcaatgtg     1500

ccgaaaacca tggaatctgg aacgttcatc actgacaaaa ctgtgctgga catgaaagct     1560

atggattcca agagcaatgg ggccattgcc tggagcaacc agacaagctt cacctgccaa     1620

gatatcttca aagagaccaa cgccacctac cccagttcag acgttccctg tgatgccacg     1680

ttgaccgaga aaagctttga aacagatatg aacctaaact ttcaaaacct gtcagttatg     1740

ggactccgaa tcctcctgct gaaagtagcg ggatttaacc tgctcatgac gctgaggctg     1800

tggtccagtt ga                                                         1812


<210>  22
<211>  45
<212>  DNA
<213>  ˹Уartificial sequence

<400>  22
tatataagag cagagctgcc accatgcagg ccgaaggccg gggca                       45


<210>  23
<211>  42
<212>  DNA
<213>  ˹Уartificial sequence

<400>  23
tgattgtcga cgcccttagc gcctctgccc tgagggaggc tg                          42


<210>  24
<211>  57
<212>  DNA
<213>  ˹Уartificial sequence

<400>  24
atgactgaat ataaacttgt ggtagttgga gctgacggcg taggcaagag tgccttg          57


<210>  25
<211>  46
<212>  DNA
<213>  ˹Уartificial sequence

<400>  25
tgattgtcga cgcccttaca taattacaca ctttgtcttt gacttc                      46


<210>  26
<211>  40
<212>  DNA
<213>  ˹Уartificial sequence

<400>  26
ctcatagcgc gtaatggctc cggtgcccgt cagtgggcag                             40


<210>  27
<211>  39
<212>  DNA
<213>  ˹Уartificial sequence

<400>  27
gaattcgcta gctctagatc acgacacctg aaatggaag                              39


<210>  28
<211>  1098
<212>  DNA
<213>  ˣHomo sapiens

<400>  28
atggccgtca tggcgccccg aaccctcgtc ctgctactct cgggggctct ggccctgacc       60

cagacctggg cgggctctca ctccatgagg tatttcttca catccgtgtc ccggcccggc      120

cgcggggagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt cgtgcggttc      180

gacagcgacg ccgcgagcca gaggatggag ccgcgggcgc cgtggataga gcaggagggt      240

ccggagtatt gggacgggga gacacggaaa gtgaaggccc actcacagac tcaccgagtg      300

gacctgggga ccctgcgcgg ctactacaac cagagcgagg ccggttctca caccgtccag      360

aggatgtatg gctgcgacgt ggggtcggac tggcgcttcc tccgcgggta ccaccagtac      420

gcctacgacg gcaaggatta catcgccctg aaagaggacc tgcgctcttg gaccgcggcg      480

gacatggcag ctcagaccac caagcacaag tgggaggcgg cccatgtggc ggagcagttg      540

agagcctacc tggagggcac gtgcgtggag tggctccgca gatacctgga gaacgggaag      600

gagacgctgc agcgcacgga cgcccccaaa acgcatatga ctcaccacgc tgtctctgac      660

catgaagcca ccctgaggtg ctgggccctg agcttctacc ctgcggagat cacactgacc      720

tggcagcggg atggggagga ccagacccag gacacggagc tcgtggagac caggcctgca      780

ggggatggaa ccttccagaa gtgggcggct gtggtggtgc cttctggaca ggagcagaga      840

tacacctgcc atgtgcagca tgagggtttg cccaagcccc tcaccctgag atgggagccg      900

tcttcccagc ccaccatccc catcgtgggc atcattgctg gcctggttct ctttggagct      960

gtgatcactg gagctgtggt cgctgctgtg atgtggagga ggaagagctc agatagaaaa     1020

ggagggagct actctcaggc tgcaagcagt gacagtgccc agggctctga tgtgtctctc     1080

acagcttgta aagtgtga                                                   1098


<210>  29
<211>  198
<212>  DNA
<213>  ˹Уartificial sequence

<400>  29
atgaaaggtt ccatcttcac attgtttttg ttctccgtat tgttcgcaat cagcgaagtc       60

cgatcatccc tgttgatgtg gatcacgcag tgccgcagaa agaggtcact cttaatgtgg      120

ataacccaat gtaggcgaaa gagatcgcta ttgatgtgga ttacacagtg taggcgaagg      180

cggaaagacg agctttaa                                                    198


<210>  30
<211>  96
<212>  DNA
<213>  ˹Уartificial sequence

<400>  30
cgtgccaagc gatccggaag cggagcccct gtaaagcaga ctttgaattt tgaccttctc       60

aagttggcgg gagacgtcga gtccaaccct gggccc                                 96


<210>  31
<211>  1365
<212>  DNA
<213>  ˹Уartificial sequence

<400>  31
atgaaaggtt ccatcttcac attgtttttg ttctccgtat tgttcgcaat cagcgaagtc       60

cgatcatccc tgttgatgtg gatcacgcag tgccgcagaa agaggtcact cttaatgtgg      120

ataacccaat gtaggcgaaa gagatcgcta ttgatgtgga ttacacagtg tcgtcgtaag      180

cgatccggaa gcggagcccc tgtaaagcag actttgaatt ttgaccttct caagttggcg      240

ggagacgtcg agtccaaccc tgggcccatg gccgtcatgg cgccccgaac cctcgtcctg      300

ctactctcgg gggctctggc cctgacccag acctgggcgg gctctcactc catgaggtat      360

ttcttcacat ccgtgtcccg gcccggccgc ggggagcccc gcttcatcgc agtgggctac      420

gtggacgaca cgcagttcgt gcggttcgac agcgacgccg cgagccagag gatggagccg      480

cgggcgccgt ggatagagca ggagggtccg gagtattggg acggggagac acggaaagtg      540

aaggcccact cacagactca ccgagtggac ctggggaccc tgcgcggcta ctacaaccag      600

agcgaggccg gttctcacac cgtccagagg atgtatggct gcgacgtggg gtcggactgg      660

cgcttcctcc gcgggtacca ccagtacgcc tacgacggca aggattacat cgccctgaaa      720

gaggacctgc gctcttggac cgcggcggac atggcagctc agaccaccaa gcacaagtgg      780

gaggcggccc atgtggcgga gcagttgaga gcctacctgg agggcacgtg cgtggagtgg      840

ctccgcagat acctggagaa cgggaaggag acgctgcagc gcacggacgc ccccaaaacg      900

catatgactc accacgctgt ctctgaccat gaagccaccc tgaggtgctg ggccctgagc      960

ttctaccctg cggagatcac actgacctgg cagcgggatg gggaggacca gacccaggac     1020

acggagctcg tggagaccag gcctgcaggg gatggaacct tccagaagtg ggcggctgtg     1080

gtggtgcctt ctggacagga gcagagatac acctgccatg tgcagcatga gggtttgccc     1140

aagcccctca ccctgagatg ggagccgtct tcccagccca ccatccccat cgtgggcatc     1200

attgctggcc tggttctctt tggagctgtg atcactggag ctgtggtcgc tgctgtgatg     1260

tggaggagga agagctcaga tagaaaagga gggagctact ctcaggctgc aagcagtgac     1320

agtgcccagg gctctgatgt gtctctcaca gcttgtaaag tgtga                     1365


<210>  32
<211>  38
<212>  DNA
<213>  ˹Уartificial sequence

<400>  32
agagctagcg aattcaacat gaaaggttcc atcttcac                               38


<210>  33
<211>  35
<212>  DNA
<213>  ˹Уartificial sequence

<400>  33
acactgtgta atccacatca atagcgatct ctttc                                  35


<210>  34
<211>  39
<212>  DNA
<213>  ˹Уartificial sequence

<400>  34
tggattacac agtgtcgtcg taagcgatcc ggaagcgcg                              39


<210>  35
<211>  39
<212>  DNA
<213>  ˹Уartificial sequence

<400>  35
cgccatgacg gccatgggcc cagggttgga ctcgacgtc                              39


<210>  36
<211>  21
<212>  DNA
<213>  ˹Уartificial sequence

<400>  36
atggccgtca tggcgccccg a                                                 21


<210>  37
<211>  27
<212>  DNA
<213>  ˹Уartificial sequence

<400>  37
tcacacttta caagctgtga gagacac                                           27


<210>  38
<211>  33
<212>  DNA
<213>  ˹Уartificial sequence

<400>  38
atgaaaggtt ccatcttcac attgtttttg ttc                                    33


<210>  39
<211>  39
<212>  DNA
<213>  ˹Уartificial sequence

<400>  39
cgccatgacg gccatgggcc cagggttgga ctcgacgtc                              39


<210>  40
<211>  28
<212>  DNA
<213>  ˹Уartificial sequence

<400>  40
atgagacata ttatctgcca cggaggtg                                          28


<210>  41
<211>  25
<212>  DNA
<213>  ˹Уartificial sequence

<400>  41
ttatggcctg gggcgtttac agctc                                             25


<210>  42
<211>  984
<212>  DNA
<213>  5ٲType 5 Adenovirus

<400>  42
atgagacata ttatctgcca cggaggtgtt attaccgaag aaatggccgc cagtcttttg       60

gaccagctga tcgaagaggt actggctgat aatcttccac ctcctagcca ttttgaacca      120

cctacccttc acgaactgta tgatttagac gtgacggccc ccgaagatcc caacgaggag      180

gcggtttcgc agatttttcc cgagtctgta atgttggcgg tgcaggaagg gattgactta      240

ttcacttttc cgccggcgcc cggttctccg gagccgcctc acctttcccg gcagcccgag      300

cagccggagc agagagcctt gggtccggtt tctatgccaa accttgtgcc ggaggtgatc      360

gatcttacct gccacgaggc tggctttcca cccagtgacg acgaggatga agagggtgag      420

gagtttgtgt tagattatgt ggagcacccc gggcacggtt gcaggtcttg tcattatcac      480

cggaggaata cgggggaccc agatattatg tgttcgcttt gctatatgag gacctgtggc      540

atgtttgtct acagtaagtg aaaattatgg gcagtcggtg atagagtggt gggtttggtg      600

tggtaatttt tttttaattt ttacagtttt gtggtttaaa gaattttgta ttgtgatttt      660

ttaaaaggtc ctgtgtctga acctgagcct gagcccgagc cagaaccgga gcctgcaaga      720

cctacccggc gtcctaaatt ggtgcctgct atcctgagac gcccgacatc acctgtgtct      780

agagaatgca atagtagtac ggatagctgt gactccggtc cttctaacac acctcctgag      840

atacacccgg tggtcccgct gtgccccatt aaaccagttg ccgtgagagt tggtgggcgt      900

cgccaggctg tggaatgtat cgaggacttg cttaacgagt ctgggcaacc tttggacttg      960

agctgtaaac gccccaggcc ataa                                             984


<210>  43
<211>  281
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  43

Met Arg His Ile Ile Cys His Gly Gly Val Ile Thr Glu Glu Met Ala 
1               5                   10                  15      


Ala Ser Leu Leu Asp Gln Leu Ile Glu Glu Val Leu Ala Asp Asn Leu 
            20                  25                  30          


Pro Pro Pro Ser His Phe Glu Pro Pro Thr Leu His Glu Leu Tyr Asp 
        35                  40                  45              


Leu Asp Val Thr Ala Pro Glu Asp Pro Asn Glu Glu Ala Val Ser Gln 
    50                  55                  60                  


Ile Phe Pro Asp Ser Val Met Leu Ala Val Gln Glu Gly Ile Asp Leu 
65                  70                  75                  80  


Leu Thr Phe Pro Pro Ala Pro Gly Ser Pro Glu Pro Pro His Leu Ser 
                85                  90                  95      


Arg Gln Pro Glu Gln Pro Glu Gln Arg Ala Leu Gly Pro Val Ser Met 
            100                 105                 110         


Pro Asn Leu Val Pro Glu Val Ile Asp Pro Pro Ser Asp Asp Glu Asp 
        115                 120                 125             


Glu Glu Gly Glu Glu Phe Val Leu Asp Tyr Val Glu His Pro Gly His 
    130                 135                 140                 


Gly Cys Arg Ser Cys His Tyr His Arg Arg Asn Thr Gly Asp Pro Asp 
145                 150                 155                 160 


Ile Met Cys Ser Leu Cys Tyr Met Arg Thr Cys Gly Met Phe Val Tyr 
                165                 170                 175     


Ser Pro Val Ser Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro Glu Pro 
            180                 185                 190         


Ala Arg Pro Thr Arg Arg Pro Lys Met Ala Pro Ala Ile Leu Arg Arg 
        195                 200                 205             


Pro Thr Ser Pro Val Ser Arg Glu Cys Asn Ser Ser Thr Asp Ser Cys 
    210                 215                 220                 


Asp Ser Gly Pro Ser Asn Thr Pro Pro Glu Ile His Pro Val Val Pro 
225                 230                 235                 240 


Leu Cys Pro Ile Lys Pro Val Ala Val Arg Val Gly Gly Arg Arg Gln 
                245                 250                 255     


Ala Val Glu Cys Ile Glu Asp Leu Leu Asn Glu Pro Gly Gln Pro Leu 
            260                 265                 270         


Asp Leu Ser Cys Lys Arg Pro Arg Pro 
        275                 280     


<210>  44
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  44
cgcgtcgact actgtaatag taatcaatta cgg                                    33


<210>  45
<211>  33
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  45
gacgtcgact aagatacatt gatgagtttg gac                                    33


<210>  46
<211>  25
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  46
atgagacata ttatctgcca cggag                                             25


<210>  47
<211>  24
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  47
catggtggcg aggtcagatg taac                                              24


<210>  48
<211>  388
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  48
gtgtctagag aatgcaatag tagtacggat agctgtgact ccggtccttc taacacacct       60

cctgagatac acccggtggt cccgctgtgc cccattaaac cagttgccgt gagagttggt      120

gggcgtcgcc aggctgtgga atgtatcgag gacttgctta acgagcctgg gcaacctttg      180

gacttgagct gtaaacgccc caggccataa ggtgtaaacc tgtgattgcg tgtgtggtta      240

acgcctttgt ttgctgaatg agttgatgta agtttaataa agggtgagat aatgtttaac      300

ttgcatggcg tgttaaatgg ggcggggctt aaagggtata taatgcgccg tgggctaatc      360

ttggttacat ctgacctcgc caccatgg                                         388


<210>  49
<211>  1101
<212>  DNA
<213>  ˣHomo sapiens

<400>  49
atggcggtca tggcgccccg aaccctcatc ctgctgctct cgggagccct ggccctgacc       60

gagacctggg cctgctccca ctccatgagg tatttctaca ccgccgtgtc ccggcccggc      120

cgcggagagc cccgcttcat cgcagtgggc tacgtggacg acacgcagtt cgtgcagttc      180

gacagcgacg ccgcgagtcc aagaggggag ccgcgggcgc cgtgggtgga gcaggagggg      240

ccggagtatt gggaccggga gacacagaag tacaagcgcc aggcacagac tgaccgagtg      300

agcctgcgga acctgcgcgg ctactacaac cagagcgagg ccgggtctca caccctccag      360

aggatgtatg gctgcgacct ggggcccgac gggcgcctcc tccgcgggta taaccagttc      420

gcctacgacg gcaaggatta catcgccctg aatgaggacc tgcgctcctg gaccgccgcg      480

gacaaggcgg ctcagatcac ccagcgcaag tgggaggcgg cccgtgaggc ggagcagcgg      540

agagcctacc tggagggcac gtgcgtggag tggctccgca gatacctgga gaacgggaag      600

aagacgctgc agcgcgcgga acacccaaag acacacgtga cccaccatcc cgtctctgac      660

catgaggcca ccctgaggtg ctgggccctg ggcttctacc ctgcggagat cacactgacc      720

tggcagcggg atggcgagga ccaaactcag gacaccgagc ttgtggagac caggccagca      780

ggagatggaa ccttccagaa gtgggcagct gtggtggtgc cttctggaga agagcagaga      840

tacacgtgcc atgtgcagca cgaggggctg ccagagcccc tcaccctgag atgggggcca      900

tcttcccagc ccaccatccc catcgtgggc atcgttgctg gcctggctgt cctggctgtc      960

ctagctgtcc taggagctgt gatggctgtt gtgatgtgta ggaggaagag ctcaggtgga     1020

aaaggaggga gctgctctca ggctgcgtcc agcaacagtg cccagggctc tgatgtgtct     1080

ctcacagctt gtaaagccta a                                               1101


<210>  50
<211>  210
<212>  DNA
<213>  ˹УArtificial Sequence

<400>  50
atgaaaggtt ccatcttcac attgtttttg ttctccgtat tgttcgcaat cagcgaagtc       60

cgatcaggag ctgatggcgt aggcaagagt gcccgcagaa agaggcgcag aaagaggggg      120

gccgatggtg ttggaaagag cgctaggcgg aagaggggcg ccgatggtgt cggaaaaagc      180

gcgcggcgga aacgaaaaga cgagctttaa                                       210


<210>  51
<211>  65
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  51

Met Lys Gly Ser Ile Phe Thr Leu Phe Leu Phe Ser Val Leu Phe Ala 
1               5                   10                  15      


Ile Ser Glu Val Arg Ser Ser Leu Leu Met Trp Ile Thr Gln Cys Arg 
            20                  25                  30          


Arg Lys Arg Ser Leu Leu Met Trp Ile Thr Gln Cys Arg Arg Lys Arg 
        35                  40                  45              


Ser Leu Leu Met Trp Ile Thr Gln Cys Arg Arg Arg Arg Lys Asp Glu 
    50                  55                  60                  


Leu 
65  


<210>  52
<211>  607
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  52

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
305                 310                 315                 320 


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
                325                 330                 335     


Pro Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln 
            340                 345                 350         


Trp Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser 
        355                 360                 365             


Val Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser 
    370                 375                 380                 


Ala Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu 
385                 390                 395                 400 


Thr Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly 
                405                 410                 415     


Arg Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr 
            420                 425                 430         


Ile Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val 
        435                 440                 445             


Arg Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr 
    450                 455                 460                 


Ser Leu Ile Val His Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr 
465                 470                 475                 480 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
                485                 490                 495     


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
            500                 505                 510         


Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys 
        515                 520                 525             


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
    530                 535                 540                 


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
545                 550                 555                 560 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
                565                 570                 575     


Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys 
            580                 585                 590         


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605         


<210>  53
<211>  607
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  53

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Ala Glu Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser 
    130                 135                 140                 


Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro 
            180                 185                 190         


Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu 
        195                 200                 205             


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
    210                 215                 220                 


Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly 
225                 230                 235                 240 


Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg 
                245                 250                 255     


Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
            260                 265                 270         


Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
        275                 280                 285             


Val Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn 
    290                 295                 300                 


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu 
305                 310                 315                 320 


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
                325                 330                 335     


Pro Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln 
            340                 345                 350         


Trp Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser 
        355                 360                 365             


Val Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser 
    370                 375                 380                 


Ala Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu 
385                 390                 395                 400 


Thr Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly 
                405                 410                 415     


Arg Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr 
            420                 425                 430         


Ile Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val 
        435                 440                 445             


Arg Pro Thr Ser Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr 
    450                 455                 460                 


Ser Leu Ile Val His Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr 
465                 470                 475                 480 


Gln Leu Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr 
                485                 490                 495     


Asp Phe Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr 
            500                 505                 510         


Phe Ile Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys 
        515                 520                 525             


Ser Asn Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln 
    530                 535                 540                 


Asp Ile Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro 
545                 550                 555                 560 


Cys Asp Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu 
                565                 570                 575     


Asn Phe Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys 
            580                 585                 590         


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600                 605         


<210>  54
<211>  602
<212>  PRT
<213>  ˹УArtificial Sequence

<400>  54

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr 
            20                  25                  30          


Glu Met Gly Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His 
        35                  40                  45              


Asp Tyr Leu Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu 
    50                  55                  60                  


Leu Ile Tyr Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro 
65                  70                  75                  80  


Glu Asp Arg Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Leu Gly Ser Asn Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Thr Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
    290                 295                 300                 


Arg Ala Lys Arg Ser Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn 
305                 310                 315                 320 


Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
                325                 330                 335     


Met Glu Thr Leu Leu Gly Val Ser Leu Val Ile Leu Trp Leu Gln Leu 
            340                 345                 350         


Ala Arg Val Asn Ser Gln Gln Gly Glu Glu Asp Pro Gln Ala Leu Ser 
        355                 360                 365             


Ile Gln Glu Gly Glu Asn Ala Thr Met Asn Cys Ser Tyr Lys Thr Ser 
    370                 375                 380                 


Ile Asn Asn Leu Gln Trp Tyr Arg Gln Asn Ser Gly Arg Gly Leu Val 
385                 390                 395                 400 


His Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys His Ser Gly Arg 
                405                 410                 415     


Leu Arg Val Thr Leu Asp Thr Ser Lys Lys Ser Ser Ser Leu Leu Ile 
            420                 425                 430         


Thr Ala Ser Arg Ala Ala Asp Thr Ala Ser Tyr Phe Cys Met Tyr Asp 
        435                 440                 445             


Gln Asn Gly Lys Ile Ile Phe Gly Lys Gly Thr Arg Leu His Ile Leu 
    450                 455                 460                 


Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
465                 470                 475                 480 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
                485                 490                 495     


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
            500                 505                 510         


Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
        515                 520                 525             


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
    530                 535                 540                 


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
545                 550                 555                 560 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
                565                 570                 575     


Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
            580                 585                 590         


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
        595                 600         


