                         SEQUENCE LISTING

<110>  BioNTech SE
 
<120>  AGENTS AND METHODS FOR TARGETED DELIVERY TO CELLS

<130>  674-310 PCT2

<150>  PCT/EP2020/075744
<151>  2020-09-15

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  5'-UTR

<400>  1
aacuaguauu cuucuggucc ccacagacuc agagagaacc cgccacc                     47


<210>  2
<211>  311
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3'-UTR

<400>  2
cucgagagcu cgcuuucuug cuguccaauu ucuauuaaag guuccuuugu ucccuaaguc       60

caacuacuaa acugggggau auuaugaagg gccuugagca ucuggauucu gccuaauaaa      120

aaacauuuau uuucauugcu gcgucgagag cucgcuuucu ugcuguccaa uuucuauuaa      180

agguuccuuu guucccuaag uccaacuacu aaacuggggg auauuaugaa gggccuugag      240

caucuggauu cugccuaaua aaaaacauuu auuuucauug cugcgucgag accuggucca      300

gagucgcuag c                                                           311


<210>  3
<211>  278
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  3'-UTR

<400>  3
cugguacugc augcacgcaa ugcuagcugc cccuuucccg uccuggguac cccgagucuc       60

ccccgaccuc gggucccagg uaugcuccca ccuccaccug ccccacucac caccucugcu      120

aguuccagac accucccaag cacgcagcaa ugcagcucaa aacgcuuagc cuagccacac      180

ccccacggga aacagcagug auuaaccuuu agcaauaaac gaaaguuuaa cuaagcuaua      240

cuaaccccag gguuggucaa uuucgugcca gccacacc                              278


<210>  4
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  A30L70

<400>  4
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcauaugacu aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 110


<210>  5
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  5

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Gly Phe Val Leu Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly 
                245                 250                 255     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
            260                 265                 270         


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
        275                 280                 285             


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
    290                 295                 300                 


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
305                 310                 315                 320 


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
                325                 330                 335     


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
            340                 345                 350         


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        355                 360                 365             


Ser Ser Gly Gly Ser His His His His His His 
    370                 375                 


<210>  6
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  6

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Ile 
        35                  40                  45              


Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Glu Arg Arg Val Met Val Ala Ala Val Ser Glu Arg Gly Asn Ala Met 
65                  70                  75                  80  


Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val Thr Arg Asp Phe Thr 
                85                  90                  95      


Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg Val Asp Ser Phe His 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
            180                 185                 190         


Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr 
        195                 200                 205             


Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Phe Val Leu Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
            260                 265                 270         


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
        275                 280                 285             


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
    290                 295                 300                 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
305                 310                 315                 320 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
                325                 330                 335     


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
            340                 345                 350         


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
        355                 360                 365             


Ser Cys Gly Gly Ser His His His His His His 
    370                 375                 


<210>  7
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  7

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Ile Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Gly Phe Val Leu Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
    130                 135                 140                 


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
                165                 170                 175     


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
        195                 200                 205             


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
    210                 215                 220                 


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
225                 230                 235                 240 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln 
465                 470                 475                 480 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                485                 490                 495     


Cys Thr Ala Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met 
            500                 505                 510         


Gly Trp Tyr Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala 
        515                 520                 525             


Val Ser Glu Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg 
    530                 535                 540                 


Phe Thr Val Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met 
545                 550                 555                 560 


Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu 
                565                 570                 575     


Glu Asp Arg Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln 
            580                 585                 590         


Val Thr Val Ser Ser Gly Gly Ser His His His His His His 
        595                 600                 605     


<210>  8
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  8

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Ile 
        35                  40                  45              


Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Glu Arg Arg Val Met Val Ala Ala Val Ser Glu Arg Gly Asn Ala Met 
65                  70                  75                  80  


Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val Thr Arg Asp Phe Thr 
                85                  90                  95      


Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg Val Asp Ser Phe His 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly 
            180                 185                 190         


Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr 
        195                 200                 205             


Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
    210                 215                 220                 


Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr Ser Glu Asp 
225                 230                 235                 240 


Ser Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Gly Phe Val Leu Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly 
            260                 265                 270         


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
        275                 280                 285             


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
    290                 295                 300                 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
305                 310                 315                 320 


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
                325                 330                 335     


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
            340                 345                 350         


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
        355                 360                 365             


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
    370                 375                 380                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
385                 390                 395                 400 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                405                 410                 415     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            420                 425                 430         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        435                 440                 445             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    450                 455                 460                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
465                 470                 475                 480 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                485                 490                 495     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            500                 505                 510         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        515                 520                 525             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    530                 535                 540                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
545                 550                 555                 560 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                565                 570                 575     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            580                 585                 590         


Leu Ser Pro Gly Lys Gly Gly Ser His His His His His His 
        595                 600                 605     


<210>  9
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  9

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Leu His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Trp Val Tyr Ser Thr Ser Asn Leu Pro Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Gly Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
            100                 105                 110         


Ser Ile Tyr Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  10
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  10

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Ile 
        35                  40                  45              


Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Glu Arg Arg Val Met Val Ala Ala Val Ser Glu Arg Gly Asn Ala Met 
65                  70                  75                  80  


Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val Thr Arg Asp Phe Thr 
                85                  90                  95      


Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg Val Asp Ser Phe His 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Pro Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                165                 170                 175     


Arg Thr Tyr Arg Gly Tyr Ser Met Ala Trp Phe Arg Gln Ser Pro Gly 
            180                 185                 190         


Lys Glu Arg Glu Phe Val Ala Ala Ile Val Trp Ser Asp Gly Asn Thr 
        195                 200                 205             


Tyr Tyr Glu Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser 
    210                 215                 220                 


Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr Asn Leu Lys Pro Glu Asp 
225                 230                 235                 240 


Thr Ala Leu Tyr Tyr Cys Ala Ala Lys Ile Arg Pro Tyr Ile Phe Lys 
                245                 250                 255     


Ile Ala Gly Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Ser His His His His His His 
        275                 280             


<210>  11
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  11

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Pro Val Gln 
            20                  25                  30          


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Tyr 
        35                  40                  45              


Arg Gly Tyr Ser Met Ala Trp Phe Arg Gln Ser Pro Gly Lys Glu Arg 
    50                  55                  60                  


Glu Phe Val Ala Ala Ile Val Trp Ser Asp Gly Asn Thr Tyr Tyr Glu 
65                  70                  75                  80  


Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Thr Asn Leu Lys Pro Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Ala Lys Ile Arg Pro Tyr Ile Phe Lys Ile Ala Gly 
        115                 120                 125             


Gln Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
                165                 170                 175     


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
            180                 185                 190         


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
        195                 200                 205             


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
    210                 215                 220                 


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
225                 230                 235                 240 


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
                245                 250                 255     


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Ser His His His His His His 
        275                 280             


<210>  12
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  12

Met Asp Trp Thr Trp Arg Val Phe Cys Leu Leu Ala Val Ala Pro Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Ile 
        35                  40                  45              


Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly 
    50                  55                  60                  


Glu Arg Arg Val Met Val Ala Ala Val Ser Glu Arg Gly Asn Ala Met 
65                  70                  75                  80  


Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val Thr Arg Asp Phe Thr 
                85                  90                  95      


Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg Val Asp Ser Phe His 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
145                 150                 155                 160 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            180                 185                 190         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
        195                 200                 205             


Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
    210                 215                 220                 


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
225                 230                 235                 240 


Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
        275                 280                 285             


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
    290                 295                 300                 


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
305                 310                 315                 320 


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
                325                 330                 335     


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
            340                 345                 350         


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        355                 360                 365             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
    370                 375                 380                 


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Ser His His His His His His 
                405                 


<210>  13
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Docketing compound

<400>  13

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
    50                  55                  60                  


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
65                  70                  75                  80  


Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
145                 150                 155                 160 


Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser Val Lys Met Ser Cys Lys 
                165                 170                 175     


Thr Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val Lys Gln 
            180                 185                 190         


Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro Ser Arg 
        195                 200                 205             


Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr 
    210                 215                 220                 


Thr Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
225                 230                 235                 240 


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp Asp His 
                245                 250                 255     


Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser 
        275                 280                 285             


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr 
    290                 295                 300                 


Ala Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp 
305                 310                 315                 320 


Tyr Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser 
                325                 330                 335     


Glu Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr 
            340                 345                 350         


Val Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn 
        355                 360                 365             


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp 
    370                 375                 380                 


Arg Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
385                 390                 395                 400 


Val Ser Ser Gly Gly Ser His His His His His His 
                405                 410         


<210>  14
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag

<400>  14

Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu 
1               5                   10              


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1

<400>  15

Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly 
1               5                   10              


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2

<400>  16

Ala Val Ser Glu Arg Gly Asn Ala Met 
1               5                   


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3

<400>  17

Leu Glu Asp Arg Val Asp Ser Phe His Asp Tyr 
1               5                   10      


<210>  18
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VHH

<400>  18

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Val Thr Ile Ser Ala Leu 
            20                  25                  30          


Asn Ala Met Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Glu Arg Arg 
        35                  40                  45              


Val Met Val Ala Ala Val Ser Glu Arg Gly Asn Ala Met Tyr Arg Glu 
    50                  55                  60                  


Ser Val Gln Gly Arg Phe Thr Val Thr Arg Asp Phe Thr Asn Lys Met 
65                  70                  75                  80  


Val Ser Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys His Val Leu Glu Asp Arg Val Asp Ser Phe His Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


