               SEQUENCE LISTING

<110> ENZA ZADEN BEHEER B.V.

<120> LETTUCE PLANT RESISTANT TO DOWNY MILDEW AND RESISTANCE GENE

<130> P180893PC01

<150> PCT/EP2020/087264
<151> 2020-12-18

<160> 14

<170> BiSSAP 1.3.6

<210> 1
<211> 384
<212> DNA
<213> Lactuca sativa


<220> 
<223> wt

<400> 1
atagccttat gggggatggg cggagtgggg aagaccacga tgatgaagaa gctgaaggag      60

gtcgtggaac aaaagaaaat gttcaatatt attgttcaag tggtcatagg agagaagaca     120

aaccctattg ctattcagca agctgtagca gattacctct ctattgagct gaaagaaaac     180

actaaagaag caagagctga taagcttcgt aaatggttcg aggacgatgg aggaaagaat     240

aagttccttg taatacttga tgatgtatgg cagtttgttg atcttgaaga tattggttta     300

agtcctctgc caaataaagg tgtcaacttc aaggtcttgt tgacgtcaag agattcacat     360

gtttgcactc tgatgggagc cgaa                                            384


<210> 2
<211> 128
<212> PRT
<213> Lactuca sativa


<220> 
<223> wt

<400> 2
Ile Ala Leu Trp Gly Met Gly Gly Val Gly Lys Thr Thr Met Met Lys 
1               5                   10                  15      
Lys Leu Lys Glu Val Val Glu Gln Lys Lys Met Phe Asn Ile Ile Val 
            20                  25                  30          
Gln Val Val Ile Gly Glu Lys Thr Asn Pro Ile Ala Ile Gln Gln Ala 
        35                  40                  45              
Val Ala Asp Tyr Leu Ser Ile Glu Leu Lys Glu Asn Thr Lys Glu Ala 
    50                  55                  60                  
Arg Ala Asp Lys Leu Arg Lys Trp Phe Glu Asp Asp Gly Gly Lys Asn 
65                  70                  75                  80  
Lys Phe Leu Val Ile Leu Asp Asp Val Trp Gln Phe Val Asp Leu Glu 
                85                  90                  95      
Asp Ile Gly Leu Ser Pro Leu Pro Asn Lys Gly Val Asn Phe Lys Val 
            100                 105                 110         
Leu Leu Thr Ser Arg Asp Ser His Val Cys Thr Leu Met Gly Ala Glu 
        115                 120                 125             



<210> 3
<211> 384
<212> DNA
<213> Lactuca sativa


<220> 
<223> mut

<400> 3
atagccttat gggggatggg cggagtgggg aagaccacga tgatgaagaa gctgaaagag      60

gtcgtggaac gaaagaaaat gttcagtatt attgttcaag tggtcatagg agagaagaca     120

aaccctattg ctattcagca agctgtagca gattacctct ctatagagct gaaagaaaac     180

actaaagaag ctagagctga taagcttcgt aaatggtttg aggctgatgg aggaaagaat     240

aagttccttg taatacttga cgatgtatgg cagtttgtcg atcttgaaga tattggttta     300

agtcctctgc caaataaagg tgtcaacttc aaggtcttgt tgacgtcaag agattcacat     360

gtttgcactc tgatgggagc tgaa                                            384


<210> 4
<211> 128
<212> PRT
<213> Lactuca sativa


<220> 
<223> mut

<400> 4
Ile Ala Leu Trp Gly Met Gly Gly Val Gly Lys Thr Thr Met Met Lys 
1               5                   10                  15      
Lys Leu Lys Glu Val Val Glu Arg Lys Lys Met Phe Ser Ile Ile Val 
            20                  25                  30          
Gln Val Val Ile Gly Glu Lys Thr Asn Pro Ile Ala Ile Gln Gln Ala 
        35                  40                  45              
Val Ala Asp Tyr Leu Ser Ile Glu Leu Lys Glu Asn Thr Lys Glu Ala 
    50                  55                  60                  
Arg Ala Asp Lys Leu Arg Lys Trp Phe Glu Ala Asp Gly Gly Lys Asn 
65                  70                  75                  80  
Lys Phe Leu Val Ile Leu Asp Asp Val Trp Gln Phe Val Asp Leu Glu 
                85                  90                  95      
Asp Ile Gly Leu Ser Pro Leu Pro Asn Lys Gly Val Asn Phe Lys Val 
            100                 105                 110         
Leu Leu Thr Ser Arg Asp Ser His Val Cys Thr Leu Met Gly Ala Glu 
        115                 120                 125             



<210> 5
<211> 441
<212> DNA
<213> Lactuca sativa


<220> 
<223> wt

<400> 5
agtttgttcc gccagtttgc taaaaatgcg ggtgatgatg acctggatcc tgctttcaat      60

aggatagcag atagtattgc aagtagatgt caaggtttgc ccattgccat caaaaccatt     120

gccttaagtc ttaaaggtag aagcaagtct gcatgggacg ttgcactttc tcgtctggag     180

aatcataaga ttggtagtga agaagttgtg cgtgaagttt ttaaaattag ctatgacaat     240

ctccaagatg aggttactaa atctattttt ttactttgtg ctttatttcc tgaagatttt     300

gatattccta ctgaggagtt gatgaggtat ggatggggct tgaaattatt tatagaagca     360

aaaactataa gtgaagcaag aaacaggctc aacacctgca ctgagcggct tagggagaca     420

aatttgttat ttggaagtga t                                               441


<210> 6
<211> 147
<212> PRT
<213> Lactuca sativa


<220> 
<223> wt

<400> 6
Ser Leu Phe Arg Gln Phe Ala Lys Asn Ala Gly Asp Asp Asp Leu Asp 
1               5                   10                  15      
Pro Ala Phe Asn Arg Ile Ala Asp Ser Ile Ala Ser Arg Cys Gln Gly 
            20                  25                  30          
Leu Pro Ile Ala Ile Lys Thr Ile Ala Leu Ser Leu Lys Gly Arg Ser 
        35                  40                  45              
Lys Ser Ala Trp Asp Val Ala Leu Ser Arg Leu Glu Asn His Lys Ile 
    50                  55                  60                  
Gly Ser Glu Glu Val Val Arg Glu Val Phe Lys Ile Ser Tyr Asp Asn 
65                  70                  75                  80  
Leu Gln Asp Glu Val Thr Lys Ser Ile Phe Leu Leu Cys Ala Leu Phe 
                85                  90                  95      
Pro Glu Asp Phe Asp Ile Pro Thr Glu Glu Leu Met Arg Tyr Gly Trp 
            100                 105                 110         
Gly Leu Lys Leu Phe Ile Glu Ala Lys Thr Ile Ser Glu Ala Arg Asn 
        115                 120                 125             
Arg Leu Asn Thr Cys Thr Glu Arg Leu Arg Glu Thr Asn Leu Leu Phe 
    130                 135                 140                 
Gly Ser Asp 
145         

<210> 7
<211> 441
<212> DNA
<213> Lactuca sativa


<220> 
<223> mut

<400> 7
agtttgttcc gccagtttgc taaaaatgcg ggtgatgatg acctggatcc tgctttcatt      60

gggatagcag atagtattgc aagtagatgt caaggtttgc ccattgccat caaaaccatt     120

gccttaagtc ttaaaggtag aagcaagtct gcatgggacg tcgcactttc tcgtctggag     180

aatcataaga ttggtagtga agaagttgtg cgtgaagttt ttaaaattag ctatgacaat     240

ctccaagatg aggttactaa atctattttt ttactttgtg ctttatttcc tgaagatttt     300

gatattccta ttgaggagtt ggtgaggtat gggtggggct tgaaattatt tatagaagca     360

aaaactataa gagaagcaag aaacaggctc aacaactgca ctgagcggct tagggagaca     420

aatttgttat ttggaagtga t                                               441


<210> 8
<211> 147
<212> PRT
<213> Lactuca sativa


<220> 
<223> mut

<400> 8
Ser Leu Phe Arg Gln Phe Ala Lys Asn Ala Gly Asp Asp Asp Leu Asp 
1               5                   10                  15      
Pro Ala Phe Ile Gly Ile Ala Asp Ser Ile Ala Ser Arg Cys Gln Gly 
            20                  25                  30          
Leu Pro Ile Ala Ile Lys Thr Ile Ala Leu Ser Leu Lys Gly Arg Ser 
        35                  40                  45              
Lys Ser Ala Trp Asp Val Ala Leu Ser Arg Leu Glu Asn His Lys Ile 
    50                  55                  60                  
Gly Ser Glu Glu Val Val Arg Glu Val Phe Lys Ile Ser Tyr Asp Asn 
65                  70                  75                  80  
Leu Gln Asp Glu Val Thr Lys Ser Ile Phe Leu Leu Cys Ala Leu Phe 
                85                  90                  95      
Pro Glu Asp Phe Asp Ile Pro Ile Glu Glu Leu Val Arg Tyr Gly Trp 
            100                 105                 110         
Gly Leu Lys Leu Phe Ile Glu Ala Lys Thr Ile Arg Glu Ala Arg Asn 
        115                 120                 125             
Arg Leu Asn Asn Cys Thr Glu Arg Leu Arg Glu Thr Asn Leu Leu Phe 
    130                 135                 140                 
Gly Ser Asp 
145         

<210> 9
<211> 121
<212> DNA
<213> Artificial Sequence


<220> 
<223> marker 1

<400> 9
taatggctta catgtgccca atccattcgt aatcggctcg ggtcctccag ggaccaacta     60

taaagtcatg aaaaaagctt tcgttgaagg ctggggtgca gtcatagcta aaatagtaag    120

t                                                                    121


<210> 10
<211> 80
<212> DNA
<213> Artificial Sequence


<220> 
<223> marker 2

<400> 10
tgaagatgta tacgaggagc cagttttgga cattgacaat gctgataagg gtaatcccct     60

ggctgtggtt gagtacattg                                                 80


<210> 11
<211> 225
<212> DNA
<213> Artificial Sequence


<220> 
<223> VIGS

<400> 11
tgttcattaa ggatgtttga ttgctcttca attggtaatc ttctcaacat ggaagtgctc     60

agctttgcta attctaacat tgaatggtta ccatctacaa ttggaaattt gaagaagcta    120

aggctactag atttgacaaa ttgtaaaggt cttcgtatag ataatggtgt cttaaaaaat    180

ttggtcaaac ttgaagagct ttatatgggt gttaatcgtc cgtat                    225


<210> 12
<211> 250
<212> DNA
<213> Artificial Sequence


<220> 
<223> VIGS

<400> 12
agaatcttga acgattcaag atctcagtgg gatgctcttt tgatgaaaat atcaatatga     60

gtagccactc atacgaaaac atgttgcaat tggtgaccaa caaaggtgat gtattagact    120

ctaaacttaa tgggttattt ttgaaaacag aggtgctttt tttaagtgtg catggcatga    180

atgatcttga agatgttgag gtgaagtcga cacatcctac tcagtcctct tcattctgca    240

atttaaaagt                                                           250


<210> 13
<211> 3027
<212> DNA
<213> Lactuca sativa


<220> 
<223> cDNA

<400> 13
atgtcggacc caacggggat tgctggtgcc attattaacc caattgctca gacggccttg      60

gttcccgtta cggaccatgt aggctacatg atttcctgca gaaaatatgt gagggttatg     120

cagacgaaaa tgagagagtt gaatacctca agaatcagtg tagaggaaca cattagccgg     180

aacacaagaa atcatcttca gattccatct caaattaagg attggttgga ccaagtagaa     240

gggatcagag cgaatgttgc aaactttcca attgatgtca tcagttgttg tagtctcagg     300

atcaggcaca agcttggaca gaaagccttc aagataactg agcagatcga aagtctaacg     360

agacaaaact cgctgattat ctggactgat gaacctgttc ccctgggaag agttggttcc     420

aagattgcat ccacctctgc agcatcaagt gatcaccacg atgtcttccc ttcaagagag     480

caaattttta ggaaagcact agaagcactt gaacccgtcc aaaaatccca catgatagcc     540

ttatggggga tgggcggagt ggggaagacc acgatgatga agaagctgaa ggaggttgtg     600

gaacgaaaga aaatgttcag tattattgtt caagtggtca taggagagaa gacaaaccct     660

attgctattc agcaagctgt agcagattac ctctctatag agctgaaaga aaacactaaa     720

gaagctagag ctgataagct tcgtaaatgg tttgaggctg atggaggaaa gaataagttc     780

cttgtaatac ttgacgatgt atggcagttt gtcgatcttg aagatattgg tttaagtcct     840

ctgccaaata aaggtgtcaa cttcaaggtc ttgttgacgt caagagattc acatgtttgc     900

actctgatgg gagctgaagc caattcaatt ctcaatataa aagttttaaa agatgtagaa     960

ggaaaaagtt tgttccgcca gtttgctaaa aatgcgggtg atgatgacct ggatcctgct    1020

ttcattggga tagcagatag tattgcaagt agatgtcaag gtttgcccat tgccatcaaa    1080

accattgcct taagtcttaa aggtagaagc aagtctgcat gggacgtcgc actttctcgt    1140

ctggagaatc ataagattgg tagtgaagaa gttgtgcgtg aagtttttaa aattagctat    1200

gacaatctcc aagatgaggt tactaaatct atttttttac tttgtgcttt atttcctgaa    1260

gattttgata ttcctattga ggagttggtg aggtatgggt ggggcttgaa attatttata    1320

gaagcaaaaa ctataagaga agcaagaaac aggctcaaca actgcactga gcggcttagg    1380

gagacaaatt tgttatttgg aagtgatgac tttgggtgcg tcaagatgca cgatgtggtg    1440

cgtgattttg ttttgcatat gttttcagaa gtcgagcatg cttcaattgt caaccatggt    1500

aacatgtcag agtggccaga gaaaaatgat accagcaact cttgtaaaag aatttcatta    1560

acatgcaagg gtatgtctaa gtttcctaaa gacatcaact atccaaacct ttcgattttg    1620

aaacttatgc atggagataa gtcgctgtgc tttcctgaaa acttttatgg aatgatggaa    1680

aaggttcagg taatatcata tgataaattg atgtatccat tgcttccctc atcacttgaa    1740

tgctccacca accttcgagt gcttcatctc catgaatgtt cattatggat gtttaattgc    1800

tcttcaattg gtaatcttct caacatggaa gtgctcagct ttgctaattc tcgcattgaa    1860

tggttaccat ctacaattgg aaatttgaag aagctaaggc tactagattt gacaaattgt    1920

ggaggtcttc gtatagataa tggtgtctta aaaaatttgg tcaaacttga agagctttat    1980

atgggtgtta atcatccgga tggacaggcc gttagcttga cagatgaaaa ctgcaatgaa    2040

atggcagagc gttcaaaaaa ccttcttgca ctaggatctg agttgtttga atacaatgct    2100

caagtgaaga atatatcctt cgagaatctt gaacgattca agatctcagt gggatgttct    2160

ttagatggat atttcagtaa aagcaggcac tcatacgaaa acacgttgaa gttggacatt    2220

gacaaaggcg aactattgga atcccgaatg aacgggttgt ttgagaaaac ggaggttctt    2280

tgtttaagtg tgggggatat gtatcatctt tcagatgtta aggtgaagtc ctcttcgttc    2340

tacaatttaa gagtccttgt cgtttcagag tgtgcagagt tgaaacacct cttcacactt    2400

ggtgttgcaa acactttgtc aaagcttgag catcttgaag tttacaaatg cgataatatg    2460

gaagaactca tacatatcgg gggtagtgaa ggagatacaa ttacattccc caagctgaag    2520

cttttatatt tgtgtgggct gccaaaccta ttgggtttgt gtcttaatgt caacacaatt    2580

gagctaccag aacttgtgca aatgacgctt tacagcattc cgggtttcac aagcatttat    2640

ccgcggagca agttggaagc atctagtttg ttgaaagaag aggttgtgat tcctaagttg    2700

gatatacttg aaattcatga catggagaat ttaaaggaaa tatggcctag tgagcttagt    2760

agaggtgaga aagttaagtt gagagagatt aaagtgagaa attgtgataa acttgtgaat    2820

ctatttccac acaatcccat gtctctgctg catcatcttg aagagcttat agtcgagaaa    2880

tgtggttcca ttgaagagtt gttcaacatc gacttggatt gtgccagtgt aattggagaa    2940

gaagacaaca atagcagctt aagaaacatc aaagtggaga attcgatgaa actaagagag    3000

gtgttggagg ataaaaggtg cagataa                                        3027


<210> 14
<211> 1008
<212> PRT
<213> Lactuca sativa


<400> 14
Met Ser Asp Pro Thr Gly Ile Ala Gly Ala Ile Ile Asn Pro Ile Ala 
1               5                   10                  15      
Gln Thr Ala Leu Val Pro Val Thr Asp His Val Gly Tyr Met Ile Ser 
            20                  25                  30          
Cys Arg Lys Tyr Val Arg Val Met Gln Thr Lys Met Arg Glu Leu Asn 
        35                  40                  45              
Thr Ser Arg Ile Ser Val Glu Glu His Ile Ser Arg Asn Thr Arg Asn 
    50                  55                  60                  
His Leu Gln Ile Pro Ser Gln Ile Lys Asp Trp Leu Asp Gln Val Glu 
65                  70                  75                  80  
Gly Ile Arg Ala Asn Val Ala Asn Phe Pro Ile Asp Val Ile Ser Cys 
                85                  90                  95      
Cys Ser Leu Arg Ile Arg His Lys Leu Gly Gln Lys Ala Phe Lys Ile 
            100                 105                 110         
Thr Glu Gln Ile Glu Ser Leu Thr Arg Gln Asn Ser Leu Ile Ile Trp 
        115                 120                 125             
Thr Asp Glu Pro Val Pro Leu Gly Arg Val Gly Ser Lys Ile Ala Ser 
    130                 135                 140                 
Thr Ser Ala Ala Ser Ser Asp His His Asp Val Phe Pro Ser Arg Glu 
145                 150                 155                 160 
Gln Ile Phe Arg Lys Ala Leu Glu Ala Leu Glu Pro Val Gln Lys Ser 
                165                 170                 175     
His Met Ile Ala Leu Trp Gly Met Gly Gly Val Gly Lys Thr Thr Met 
            180                 185                 190         
Met Lys Lys Leu Lys Glu Val Val Glu Arg Lys Lys Met Phe Ser Ile 
        195                 200                 205             
Ile Val Gln Val Val Ile Gly Glu Lys Thr Asn Pro Ile Ala Ile Gln 
    210                 215                 220                 
Gln Ala Val Ala Asp Tyr Leu Ser Ile Glu Leu Lys Glu Asn Thr Lys 
225                 230                 235                 240 
Glu Ala Arg Ala Asp Lys Leu Arg Lys Trp Phe Glu Ala Asp Gly Gly 
                245                 250                 255     
Lys Asn Lys Phe Leu Val Ile Leu Asp Asp Val Trp Gln Phe Val Asp 
            260                 265                 270         
Leu Glu Asp Ile Gly Leu Ser Pro Leu Pro Asn Lys Gly Val Asn Phe 
        275                 280                 285             
Lys Val Leu Leu Thr Ser Arg Asp Ser His Val Cys Thr Leu Met Gly 
    290                 295                 300                 
Ala Glu Ala Asn Ser Ile Leu Asn Ile Lys Val Leu Lys Asp Val Glu 
305                 310                 315                 320 
Gly Lys Ser Leu Phe Arg Gln Phe Ala Lys Asn Ala Gly Asp Asp Asp 
                325                 330                 335     
Leu Asp Pro Ala Phe Ile Gly Ile Ala Asp Ser Ile Ala Ser Arg Cys 
            340                 345                 350         
Gln Gly Leu Pro Ile Ala Ile Lys Thr Ile Ala Leu Ser Leu Lys Gly 
        355                 360                 365             
Arg Ser Lys Ser Ala Trp Asp Val Ala Leu Ser Arg Leu Glu Asn His 
    370                 375                 380                 
Lys Ile Gly Ser Glu Glu Val Val Arg Glu Val Phe Lys Ile Ser Tyr 
385                 390                 395                 400 
Asp Asn Leu Gln Asp Glu Val Thr Lys Ser Ile Phe Leu Leu Cys Ala 
                405                 410                 415     
Leu Phe Pro Glu Asp Phe Asp Ile Pro Ile Glu Glu Leu Val Arg Tyr 
            420                 425                 430         
Gly Trp Gly Leu Lys Leu Phe Ile Glu Ala Lys Thr Ile Arg Glu Ala 
        435                 440                 445             
Arg Asn Arg Leu Asn Asn Cys Thr Glu Arg Leu Arg Glu Thr Asn Leu 
    450                 455                 460                 
Leu Phe Gly Ser Asp Asp Phe Gly Cys Val Lys Met His Asp Val Val 
465                 470                 475                 480 
Arg Asp Phe Val Leu His Met Phe Ser Glu Val Glu His Ala Ser Ile 
                485                 490                 495     
Val Asn His Gly Asn Met Ser Glu Trp Pro Glu Lys Asn Asp Thr Ser 
            500                 505                 510         
Asn Ser Cys Lys Arg Ile Ser Leu Thr Cys Lys Gly Met Ser Lys Phe 
        515                 520                 525             
Pro Lys Asp Ile Asn Tyr Pro Asn Leu Ser Ile Leu Lys Leu Met His 
    530                 535                 540                 
Gly Asp Lys Ser Leu Cys Phe Pro Glu Asn Phe Tyr Gly Met Met Glu 
545                 550                 555                 560 
Lys Val Gln Val Ile Ser Tyr Asp Lys Leu Met Tyr Pro Leu Leu Pro 
                565                 570                 575     
Ser Ser Leu Glu Cys Ser Thr Asn Leu Arg Val Leu His Leu His Glu 
            580                 585                 590         
Cys Ser Leu Trp Met Phe Asn Cys Ser Ser Ile Gly Asn Leu Leu Asn 
        595                 600                 605             
Met Glu Val Leu Ser Phe Ala Asn Ser Arg Ile Glu Trp Leu Pro Ser 
    610                 615                 620                 
Thr Ile Gly Asn Leu Lys Lys Leu Arg Leu Leu Asp Leu Thr Asn Cys 
625                 630                 635                 640 
Gly Gly Leu Arg Ile Asp Asn Gly Val Leu Lys Asn Leu Val Lys Leu 
                645                 650                 655     
Glu Glu Leu Tyr Met Gly Val Asn His Pro Asp Gly Gln Ala Val Ser 
            660                 665                 670         
Leu Thr Asp Glu Asn Cys Asn Glu Met Ala Glu Arg Ser Lys Asn Leu 
        675                 680                 685             
Leu Ala Leu Gly Ser Glu Leu Phe Glu Tyr Asn Ala Gln Val Lys Asn 
    690                 695                 700                 
Ile Ser Phe Glu Asn Leu Glu Arg Phe Lys Ile Ser Val Gly Cys Ser 
705                 710                 715                 720 
Leu Asp Gly Tyr Phe Ser Lys Ser Arg His Ser Tyr Glu Asn Thr Leu 
                725                 730                 735     
Lys Leu Asp Ile Asp Lys Gly Glu Leu Leu Glu Ser Arg Met Asn Gly 
            740                 745                 750         
Leu Phe Glu Lys Thr Glu Val Leu Cys Leu Ser Val Gly Asp Met Tyr 
        755                 760                 765             
His Leu Ser Asp Val Lys Val Lys Ser Ser Ser Phe Tyr Asn Leu Arg 
    770                 775                 780                 
Val Leu Val Val Ser Glu Cys Ala Glu Leu Lys His Leu Phe Thr Leu 
785                 790                 795                 800 
Gly Val Ala Asn Thr Leu Ser Lys Leu Glu His Leu Glu Val Tyr Lys 
                805                 810                 815     
Cys Asp Asn Met Glu Glu Leu Ile His Ile Gly Gly Ser Glu Gly Asp 
            820                 825                 830         
Thr Ile Thr Phe Pro Lys Leu Lys Leu Leu Tyr Leu Cys Gly Leu Pro 
        835                 840                 845             
Asn Leu Leu Gly Leu Cys Leu Asn Val Asn Thr Ile Glu Leu Pro Glu 
    850                 855                 860                 
Leu Val Gln Met Thr Leu Tyr Ser Ile Pro Gly Phe Thr Ser Ile Tyr 
865                 870                 875                 880 
Pro Arg Ser Lys Leu Glu Ala Ser Ser Leu Leu Lys Glu Glu Val Val 
                885                 890                 895     
Ile Pro Lys Leu Asp Ile Leu Glu Ile His Asp Met Glu Asn Leu Lys 
            900                 905                 910         
Glu Ile Trp Pro Ser Glu Leu Ser Arg Gly Glu Lys Val Lys Leu Arg 
        915                 920                 925             
Glu Ile Lys Val Arg Asn Cys Asp Lys Leu Val Asn Leu Phe Pro His 
    930                 935                 940                 
Asn Pro Met Ser Leu Leu His His Leu Glu Glu Leu Ile Val Glu Lys 
945                 950                 955                 960 
Cys Gly Ser Ile Glu Glu Leu Phe Asn Ile Asp Leu Asp Cys Ala Ser 
                965                 970                 975     
Val Ile Gly Glu Glu Asp Asn Asn Ser Ser Leu Arg Asn Ile Lys Val 
            980                 985                 990         
Glu Asn Ser Met Lys Leu Arg Glu Val Leu Glu Asp Lys Arg Cys Arg 
        995                 1000                1005            



