<110>    RTCURE Co., Ltd

<120>    Gene therapy vector with minimizing recombination, recombinant
         retrovirus comprising the vector and pharmaceutical composition
         for preventing or treating cancer comprising the recombinant
         retrovirus

<130>    2021FPO-09-001/PCT

<150>    KR 10-2020-0120797
<151>    2020-09-18

<160>    66

<170>    KoPatentIn 3.0

<210>    1
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    GaLV 1624F


<400>    1
gactcagtca gcaagttaga g                                                   21


<210>    2
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MFGSacIR


<400>    2
caatcggagg actggcgccc cgagtga                                             27


<210>    3
<211>    646
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV promoter


<400>    3
aacaggaaag ttccattgga gccaagtaca ttgagtcaat agggactttc caatgggttt         60

tgcccagtac ataaggtcaa tgggaggtaa gccaatgggt ttttcccatt actggcacgt        120

atactgagtc attagggact ttccaatggg ttttgcccag tacataaggt caataggggt        180

gaatcaacag gaaagtccca ttggagccaa gtacactgag tcaataggga ctttccattg        240

ggttttgccc agtacaaaag gtcaataggg ggtgagtcaa tgggtttttc ccattattgg        300

cacgtacata aggtcaatag gggtgagtca ttgggttttt ccagccaatt taattaaaac        360

gccatgtact ttcccaccat tgacgtcaat gggctattga aactaatgca acgtgacctt        420

taaacggtac tttcccatag ctgattaatg ggaaagtacc gttctcgagc caatacacgt        480

caatgggaag tgaaagggca gccaaaacgt aacaccgccc cggttttccc tggaaattcc        540

atattggcac gcattctatt ggctgagctg cgttcacgtg ggtataagag gcgcgaccag        600

cgtcggtacc gtcgcagtct tcggtctgac caccgtagaa cgcaga                       646


<210>    4
<211>    470
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F1 promoter


<400>    4
gggtgaatca acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc         60

attgggtttt gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta        120

ttggcacgta cataaggtca ataggggtga gtcattgggt ttttccagcc aatttaatta        180

aaacgccatg tactttccca ccattgacgt caatgggcta ttgaaactaa tgcaacgtga        240

cctttaaacg gtactttccc atagctgatt aatgggaaag taccgttctc gagccaatac        300

acgtcaatgg gaagtgaaag ggcagccaaa acgtaacacc gccccggttt tccctggaaa        360

ttccatattg gcacgcattc tattggctga gctgcgttca cgtgggtata agaggcgcga        420

ccagcgtcgg taccgtcgca gtcttcggtc tgaccaccgt agaacgcaga                   470


<210>    5
<211>    337
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F2 promoter


<400>    5
aaggtcaata ggggtgagtc attgggtttt tccagccaat ttaattaaaa cgccatgtac         60

tttcccacca ttgacgtcaa tgggctattg aaactaatgc aacgtgacct ttaaacggta        120

ctttcccata gctgattaat gggaaagtac cgttctcgag ccaatacacg tcaatgggaa        180

gtgaaagggc agccaaaacg taacaccgcc ccggttttcc ctggaaattc catattggca        240

cgcattctat tggctgagct gcgttcacgt gggtataaga ggcgcgacca gcgtcggtac        300

cgtcgcagtc ttcggtctga ccaccgtaga acgcaga                                 337


<210>    6
<211>    237
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F3 promoter


<400>    6
aacgtgacct ttaaacggta ctttcccata gctgattaat gggaaagtac cgttctcgag         60

ccaatacacg tcaatgggaa gtgaaagggc agccaaaacg taacaccgcc ccggttttcc        120

ctggaaattc catattggca cgcattctat tggctgagct gcgttcacgt gggtataaga        180

ggcgcgacca gcgtcggtac cgtcgcagtc ttcggtctga ccaccgtaga acgcaga           237


<210>    7
<211>    161
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F4 promoter


<400>    7
ggaagtgaaa gggcagccaa aacgtaacac cgccccggtt ttccctggaa attccatatt         60

ggcacgcatt ctattggctg agctgcgttc acgtgggtat aagaggcgcg accagcgtcg        120

gtaccgtcgc agtcttcggt ctgaccaccg tagaacgcag a                            161


<210>    8
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F1-PmeI


<400>    8
cggtttaaac gggtgaatca acaggaaagt ccc                                      33


<210>    9
<211>    32
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F2-PmeI


<400>    9
cggtttaaac aaggtcaata ggggtgagtc at                                       32


<210>    10
<211>    32
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F3-PmeI


<400>    10
cggtttaaac aacgtgacct ttaaacggta ct                                       32


<210>    11
<211>    31
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV F4-PmeI


<400>    11
cggtttaaac ggaagtgaaa gggcagccaa a                                        31


<210>    12
<211>    34
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV-R-NotI


<400>    12
cggcggccgc tctgcgttct acggtggtca gacc                                     34


<210>    13
<211>    32
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV R-BamHI


<400>    13
cgggatcctc tgcgttctac ggtggtcaga cc                                       32


<210>    14
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    GaLV 1932F


<400>    14
gttgctcatc ctcgggccat g                                                   21


<210>    15
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Am1801F


<400>    15
atcattgacc ctggcccttc                                                     20


<210>    16
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    pol7130F


<400>    16
cggcccggca ctcattggga g                                                   21


<210>    17
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MuLV4194F


<400>    17
agcaagctat tggccactg                                                      19


<210>    18
<211>    212
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sEF1alpha promoter


<400>    18
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgat         60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc        120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc        180

tttttcgcaa cgggtttgcc gccagaacac ag                                      212


<210>    19
<211>    2058
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    GaLV env


<400>    19
atggtattgc tgcctgggtc catgcttctc acctcaaacc tgcaccacct tcggcaccag         60

atgagtcctg ggagctggaa aagactgatc atcctcttaa gctgcgtatt cggcggcggc        120

gggacgagtc tgcaaaataa gaacccccac cagcccatga ccctcacttg gcaggtactg        180

tcccaaactg gagacgttgt ctgggataca aaggcagtcc agcccccttg gacttggtgg        240

cccacactta aacctgatgt atgtgccttg gcggctagtc ttgagtcctg ggatatcccg        300

ggaaccgatg tctcgtcctc taaacgagtc agacctccgg actcagacta tactgccgct        360

tataagcaaa tcacctgggg agccataggg tgcagctacc ctcgggctag gactagaatg        420

gcaagctcta ccttctacgt atgtccccgg gatggccgga ccctttcaga agctagaagg        480

tgcggggggc tagaatccct atactgtaaa gaatgggatt gtgagaccac ggggaccggt        540

tattggctat ctaaatcctc aaaagacctc ataactgtaa aatgggacca aaatagcgaa        600

tggactcaaa aatttcaaca gtgtcaccag accggctggt gtaaccccct taaaatagat        660

ttcacagaca aaggaaaatt atccaaggac tggataacgg gaaaaacctg gggattaaga        720

ttctatgtgt ctggacatcc aggcgtacag ttcaccattc gcttaaaaat caccaacatg        780

ccagctgtgg cagtaggtcc tgacctcgtc cttgtggaac aaggacctcc tagaacgtcc        840

ctcgctctcc cacctcctct tcccccaagg gaagcgccac cgccatctct ccccgactct        900

aactccacag ccctggcgac tagtgcacaa actcccacgg tgagaaaaac aattgttacc        960

ctaaacactc cgcctcccac cacaggcgac agactttttg atcttgtgca gggggccttc       1020

ctaaccttaa atgctaccaa cccaggggcc actgagtctt gctggctttg tttggccatg       1080

ggcccccctt attatgaagc aatagcctca tcaggagagg tcgcctactc caccgacctt       1140

gaccggtgcc gctgggggac ccaaggaaag ctcaccctca ctgaggtctc aggacacggg       1200

ttgtgcatag gaaaggtgcc ctttacccat cagcatctct gcaatcagac cctatccatc       1260

aattcctccg gagaccatca gtatctgctc ccctccaacc atagctggtg ggcttgcagc       1320

actggcctca ccccttgcct ctccacctca gtttttaatc agactagaga tttctgtatc       1380

caggtccagc tgattcctcg catctattac tatcctgaag aagttttgtt acaggcctat       1440

gacaattctc accccaggac taaaagagag gctgtctcac ttaccctagc tgttttactg       1500

gggttgggaa tcacggcggg aataggtact ggttcaactg ccttaattaa aggacctata       1560

gacctccagc aaggcctgac aagcctccag atcgccatag atgctgacct ccgggccctc       1620

caagactcag tcagcaagtt agaggactca ctgacttccc tgtccgaggt agtgctccaa       1680

aataggagag gccttgactt gctgtttcta aaagaaggtg gcctctgtgc ggccctaaag       1740

gaagagtgct gtttttacat agaccactca ggtgcagtac gggactccat gaaaaaactc       1800

aaagaaaaac tggataaaag acagttagag cgccagaaaa gccaaaactg gtatgaagga       1860

tggttcaata actccccttg gttcactacc ctgctatcaa ccatcgctgg gcccctatta       1920

ctcctccttc tgttgctcat cctcgggcca tgcatcatca ataagttagt tcaattcatc       1980

aatgatagga taagtgcagt taaaattctg gtccttagac aaaaatatca ggccctagag       2040

aacgaaggta acctttaa                                                     2058


<210>    20
<211>    1965
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MuLV env


<400>    20
atggcgcgtt caacgctctc aaaaccccct caagataaga ttaacccgtg gaagccctta         60

atagtcatgg gagtcctgtt aggagtaggg atggcagaga gcccccatca ggtctttaat        120

gtaacctgga gagtcaccaa cctgatgact gggcgtaccg ccaatgccac ctccctcctg        180

ggaactgtac aagatgcctt cccaaaatta tattttgatc tatgtgatct ggtcggagag        240

gagtgggacc cttcagacca ggaaccgtat gtcgggtatg gctgcaagta ccccgcaggg        300

agacagcgga cccggacttt tgacttttac gtgtgccctg ggcataccgt aaagtcgggg        360

tgtgggggac caggagaggg ctactgtggt aaatgggggt gtgaaaccac cggacaggct        420

tactggaagc ccacatcatc gtgggaccta atctccctta agcgcggtaa caccccctgg        480

gacacgggat gctctaaagt tgcctgtggc ccctgctacg acctctccaa agtatccaat        540

tccttccaag gggctactcg agggggcaga tgcaaccctc tagtcctaga attcactgat        600

gcaggaaaaa aggctaactg ggacgggccc aaatcgtggg gactgagact gtaccggaca        660

ggaacagatc ctattaccat gttctccctg acccggcagg tccttaatgt gggaccccga        720

gtccccatag ggcccaaccc agtattaccc gaccaaagac tcccttcctc accaatagag        780

attgtaccgg ctccacagcc acctagcccc ctcaatacca gttacccccc ttccactacc        840

agtacaccct caacctcccc tacaagtcca agtgtcccac agccaccccc aggaactgga        900

gatagactac tagctctagt caaaggagcc tatcaggcgc ttaacctcac caatcccgac        960

aagacccaag aatgttggct gtgcttagtg tcgggacctc cttattacga aggagtagcg       1020

gtcgtgggca cttataccaa tcattccacc gctccggcca actgtacggc cacttcccaa       1080

cataagctta ccctatctga agtgacagga cagggcctat gcatgggggc agtacctaaa       1140

actcaccagg ccttatgtaa caccacccaa agcgccggct caggatccta ctaccttgca       1200

gcacccgccg gaacaatgtg ggcttgcagc actggattga ctccctgctt gtccaccacg       1260

gtgctcaatc taaccacaga ttattgtgta ttagttgaac tctggcccag agtaatttac       1320

cactcccccg attatatgta tggtcagctt gaacagcgta ccaaatataa aagagagcca       1380

gtatcattga ccctggccct tctactagga ggattaacca tgggagggat tgcagctgga       1440

atagggacgg ggaccactgc cttaattaaa acccagcagt ttgagcagct tcatgccgct       1500

atccagacag acctcaacga agtcgaaaag tcaattacca acctagaaaa gtcactgacc       1560

tcgttgtctg aagtagtcct acagaaccgc agaggcctag atttgctatt cctaaaggag       1620

ggaggtctct gcgcagccct aaaagaagaa tgttgttttt atgcagacca cacggggcta       1680

gtgagagaca gcatggccaa attaagagaa aggcttaatc agagacaaaa actatttgag       1740

acaggccaag gatggttcga agggctgttt aatagatccc cctggtttac caccttaatc       1800

tccaccatca tgggacctct aatagtactc ttactgatct tactctttgg accttgcatt       1860

ctcaatcgat tagtccaatt tgttaaagac aggatatcag tggtccaggc tctagttttg       1920

actcaacaat atcaccagct gaagcctata gagtacgagc catag                       1965


<210>    21
<211>    1131
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Thymidine kinase encoding sequence


<400>    21
atggcttcgt acccctgcca tcaacacgcg tctgcgttcg accaggctgc gcgttctcgc         60

ggccatagca accgacgtac ggcgttgcgc cctcgccggc agcaagaagc cacggaagtc        120

cgcctggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc tcacgggatg        180

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac        240

gtacccgagc cgatgactta ctggcaggtg ctgggggctt ccgagacaat cgcgaacatc        300

tacaccacac aacaccgcct cgaccagggt gagatatcgg ccggggacgc ggcggtggta        360

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct        420

cctcatatcg ggggggaggc tgggagctca catgccccgc ccccggccct caccctcatc        480

ttcgaccgcc atcccatcgc cgccctcctg tgctacccgg ccgcgcgata ccttatgggc        540

agcatgacct cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc        600

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc        660

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttacggg        720

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggcggga ggattgggga        780

cagctttcgg ggacggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca        840

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc        900

aacggcgacc tgtacaacgt gtttgcctgg gccttggacg tcttggccaa acgcctccgt        960

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctgccg ggacgccctg       1020

ctgcaactta cctccgggat ggtccagacc cacgtcacca cccccggctc cataccgacg       1080

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaactg a                1131


<210>    22
<211>    477
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Human-codon optimized yeast cytosine deaminase encoding sequence


<400>    22
atggttactg ggggaatggc atctaagtgg gatcagaaag gtatggacat cgcttatgaa         60

gaggctgctc tcggctacaa agagggtgga gtgcctatcg gagggtgcct gatcaacaac        120

aaggacggca gtgtgctggg gaggggccac aatatgaggt tccaaaaagg ctccgccact        180

ctccacgggg aaattagtac cctcgagaat tgcggacgat tggaagggaa ggtgtacaag        240

gatacaacac tgtacaccac cctgtcaccc tgtgatatgt gcacaggcgc cattatcatg        300

tacggaatcc ctagatgtgt cgtgggggag aatgtaaact tcaaaagtaa gggggagaaa        360

tatctccaga cccgggggca cgaagtcgtc gttgtggacg atgaacggtg taagaagatc        420

atgaagcagt ttatcgatga gaggccccag gactggttcg aagacatcgg ggaataa           477


<210>    23
<211>    1617
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MuLV gag


<400>    23
atgggccaga ctgttaccac tcccttaagt ttgaccttag gtcactggaa agatgtcgag         60

cggatcgctc acaaccagtc ggtagatgtc aagaagagac gttgggttac cttctgctct        120

gcagaatggc caacctttaa cgtcggatgg ccgcgagacg gcacctttaa ccgagacctc        180

atcacccagg ttaagatcaa ggtcttttca cctggcccgc atggacaccc agaccaggtc        240

ccctacatcg tgacctggga agccttggct tttgaccccc ctccctgggt caagcccttt        300

gtacacccta agcctccgcc tcctcttcct ccatccgccc cgtctctccc ccttgaacct        360

cctcgttcga ccccgcctcg atcctccctt tatccagccc tcactccttc tctaggcgcc        420

aaacctaaac ctcaagttct ttctgacagt ggggggccgc tcatcgacct acttacagaa        480

gaccccccgc cttataggga cccaagacca cccccttccg acagggacgg aaatggtgga        540

gaagcgaccc ctgcgggaga ggcaccggac ccctccccaa tggcatctcg cctacgtggg        600

agacgggagc cccctgtggc cgactccact acctcgcagg cattccccct ccgcgcagga        660

ggaaacggac agcttcaata ctggccgttc tcctcttctg acctttacaa ctggaaaaat        720

aataaccctt ctttttctga agatccaggt aaactgacag ctctgatcga gtctgttctc        780

atcacccatc agcccacctg ggacgactgt cagcagctgt tggggactct gctgaccgga        840

gaagaaaaac aacgggtgct cttagaggct agaaaggcgg tgcggggcga tgatgggcgc        900

cccactcaac tgcccaatga agtcgatgcc gcttttcccc tcgagcgccc agactgggat        960

tacaccaccc aggcaggtag gaaccaccta gtccactatc gccagttgct cctagcgggt       1020

ctccaaaacg cgggcagaag ccccaccaat ttggccaagg taaaaggaat aacacaaggg       1080

cccaatgagt ctccctcggc cttcctagag agacttaagg aagcctatcg caggtacact       1140

ccttatgacc ctgaggaccc agggcaagaa actaatgtgt ctatgtcttt catttggcag       1200

tctgccccag acattgggag aaagttagag aggttagaag atttaaaaaa caagacgctt       1260

ggagatttgg ttagagaggc agaaaagatc tttaataaac gagaaacccc ggaagaaaga       1320

gaggaacgta tcaggagaga aacagaggaa aaagaagaac gccgtaggac agaggatgag       1380

cagaaagaga aagaaagaga tcgtaggaga catagagaga tgagcaagct attggccact       1440

gtcgttagtg gacagaaaca ggatagacag ggaggagaac gaaggaggtc ccaactcgat       1500

cgcgaccagt gtgcctactg caaagaaaag gggcactggg ctaaagattg tcccaagaaa       1560

ccacgaggac ctcggggacc aagaccccag acctccctcc tgaccctaga tgactag          1617


<210>    24
<211>    3635
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MuLV pol


<400>    24
ggaggtcagg gtcaggagcc cccccctgaa cccaggataa ccctcaaagt cggggggcaa         60

cccgtcacct tcctggtaga tactggggcc caacactccg tgctgaccca aaatcctgga        120

cccctaagtg ataagtctgc ctgggtccaa ggggctactg gaggaaagcg gtatcgctgg        180

accacggatc gcaaagtaca tctagctacc ggtaaggtca cccactcttt cctccatgta        240

ccagactgtc cctatcctct gttaggaaga gatttgctga ctaaactaaa agcccaaatc        300

cactttgagg gatcaggagc tcaggttatg ggaccaatgg ggcagcccct gcaagtgttg        360

accctaaata tagaagatga gcatcggcta catgagacct caaaagagcc agatgtttct        420

ctagggtcca catggctgtc tgattttcct caggcctggg cggaaaccgg gggcatggga        480

ctggcagttc gccaagctcc tctgatcata cctctgaaag caacctctac ccccgtgtcc        540

ataaaacaat accccatgtc acaagaagcc agactgggga tcaagcccca catacagaga        600

ctgttggacc agggaatact ggtaccctgc cagtccccct ggaacacgcc cctgctaccc        660

gttaagaaac cagggactaa tgattatagg cctgtccagg atctgagaga agtcaacaag        720

cgggtggaag acatccaccc caccgtgccc aacccttaca acctcttgag cgggctccca        780

ccgtcccacc agtggtacac tgtgcttgat ttaaaggatg cctttttctg cctgagactc        840

caccccacca gtcagcctct cttcgccttt gagtggagag atccagagat gggaatctca        900

ggacaattga cctggaccag actcccacag ggtttcaaaa acagtcccac cctgtttgat        960

gaggcactgc acagagacct agcagacttc cggatccagc acccagactt gatcctgcta       1020

cagtacgtgg atgacttact gctggccgcc acttctgagc tagactgcca acaaggtact       1080

cgggccctgt tacaaaccct agggaacctc gggtatcggg cctcggccaa gaaagcccaa       1140

atttgccaga aacaggtcaa gtatctgggg tatcttctaa aagagggtca gagatggctg       1200

actgaggcca gaaaagagac tgtgatgggg cagcctactc cgaagacccc tcgacaacta       1260

agggagttcc tagggacggc aggcttctgt cgcctctgga tccctgggtt tgcagaaatg       1320

gcagccccct tgtaccctct caccaaaacg gggactctgt ttaattgggg cccagaccaa       1380

caaaaggcct atcaagaaat caagcaagct cttctaactg ccccagccct ggggttgcca       1440

gatttgacta agccctttga actctttgtc gacgagaagc agggctacgc caaaggtgtc       1500

ctaacgcaaa aactgggacc ttggcgtcgg ccggtggcct acctgtccaa aaagctagac       1560

ccagtagcag ctgggtggcc cccttgccta cggatggtag cagccattgc cgtactgaca       1620

aaggatgcag gcaagctaac catgggacag ccactagtca ttctggcccc ccatgcagta       1680

gaggcactag tcaaacaacc ccccgaccgc tggctttcca acgcccggat gactcactat       1740

caggccttgc ttttggacac ggaccgggtc cagttcggac cggtggtagc cctgaacccg       1800

gctacgctgc tcccactgcc tgaggaaggg ctgcaacaca actgccttga tatcctggcc       1860

gaagcccacg gaacccgacc cgacctaacg gaccagccgc tcccagacgc cgaccacacc       1920

tggtacacgg atggaagcag tctcttacaa gagggacagc gtaaggcggg agctgcggtg       1980

accaccgaga ccgaggtaat ctgggctaaa gccctgccag ccgggacatc cgctcagcgg       2040

gctgaactga tagcactcac ccaggcccta aagatggcag aaggtaagaa gctaaatgtt       2100

tatactgata gccgttatgc ttttgctact gcccatatcc atggagaaat atacagaagg       2160

cgtgggttgc tcacatcaga aggcaaagag atcaaaaata aagacgagat cttggcccta       2220

ctaaaagccc tctttctgcc caaaagactt agcataatcc attgtccagg acatcaaaag       2280

ggacacagcg ccgaggctag aggcaaccgg atggctgacc aagcggcccg aaaggcagcc       2340

atcacagaga ctccagacac ctctaccctc ctcatagaaa attcatcacc ctacacctca       2400

gaacattttc attacacagt gactgatata aaggacctaa ccaagttggg ggccatttat       2460

gataaaacaa agaagtattg ggtctaccaa ggaaaacctg tgatgcctga ccagtttact       2520

tttgaattat tagactttct tcatcagctg actcacctca gcttctcaaa aatgaaggct       2580

ctcctagaga gaagccacag tccctactac atgctgaacc gggatcgaac actcaaaaat       2640

atcactgaga cctgcaaagc ttgtgcacaa gtcaacgcca gcaagtctgc cgttaaacag       2700

ggaactaggg tccgcgggca tcggcccggc actcattggg agatcgattt caccgagata       2760

aagcccggat tgtatggcta taaatatctt ctagttttta tagatacctt ttctggctgg       2820

atagaagcct tcccaaccaa gaaagaaacc gccaaggtcg taaccaagaa gctactagag       2880

gagatcttcc ccaggttcgg catgcctcag gtattgggaa ctgacaatgg gcctgccttc       2940

gtctccaagg tgagtcagac agtggccgat ctgttgggga ttgattggaa attacattgt       3000

gcatacagac cccaaagctc aggccaggta gaaagaatga atagaaccat caaggagact       3060

ttaactaaat taacgcttgc aactggctct agagactggg tgctcctact ccccttagcc       3120

ctgtaccgag cccgcaacac gccgggcccc catggcctca ccccatatga gatcttatat       3180

ggggcacccc cgccccttgt aaacttccct gaccctgaca tgacaagagt tactaacagc       3240

ccctctctcc aagctcactt acaggctctc tacttagtcc agcacgaagt ctggagacct       3300

ctggcggcag cctaccaaga acaactggac cgaccggtgg tacctcaccc ttaccgagtc       3360

ggcgacacag tgtgggtccg ccgacaccag actaagaacc tagaacctcg ctggaaagga       3420

ccttacacag tcctgctgac cacccccacc gccctcaaag tagacggcat cgcagcttgg       3480

atacacgccg cccacgtgaa ggctgccgac cccgggggtg gaccatcctc tagactgaca       3540

tggcgcgttc aacgctctca aaacccctta aaaataaggt taacccgcga ggccccctaa       3600

tccccttaat tcttctgatg ctcagagggg tcagt                                  3635


<210>    25
<211>    9694
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-yCD env vector


<400>    25
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taattttgct ctaagattag agctattcac aagagaaatg gggaatcact agtgaattaa       3960

accgataagc gtttttttca ataacaggaa agtcccattg gagccaagta cattgagtca       4020

atagggactt tccaatgggt tttgcccagt acataaggtc aatgggaggt aagccaatgg       4080

gtttttccca ttactggcac gtatactgag tcattaggga ctttccaatg ggttttgccc       4140

agtacataag gtcaataggg gtgaatcaac aggaaagtcc cattggagcc aagtacactg       4200

agtcaatagg gactttccat tgggttttgc ccagtacaaa aggtcaatag ggggtgagtc       4260

aatgggtttt tcccattatt ggcacgtaca taaggtcaat aggggtgagt cattgggttt       4320

ttccagccaa tttaattaaa acgccatgta ctttcccacc attgacgtca atgggctatt       4380

gaaactaatg caacgtgacc tttaaacggt actttcccat agctgattaa tgggaaagta       4440

ccgttctcga gccaatacac gtcaatggga agtgaaaggg cagccaaaac gtaacaccgc       4500

cccggttttc cctggaaatt ccatattggc acgcattcta ttggctgagc tgcgttctac       4560

gtgggtataa gaggcgcgac cagcgtcggt accgtcgcag tcttcggtct gaccaccgta       4620

gaacgcagaa ctctagaact agtcgggatc cgcgttaaca tttgcggccg ctttagttta       4680

gcttatggtg acagggggaa tggcaagcaa gtgggatcag aagggtatgg acattgccta       4740

tgaggaggcg gccttaggtt acaaagaggg tggtgttcct attggcggat gtcttatcaa       4800

taacaaagac ggaagtgttc tcggtcgtgg tcacaacatg agatttcaaa agggatccgc       4860

cacactacat ggtgagatct ccactttgga aaactgtggg agattagagg gcaaagtgta       4920

caaagatacc actttgtata cgacgctgtc tccatgcgac atgtgtacag gtgccatcat       4980

catgtatggt attccacgct gtgttgtcgg tgagaacgtt aatttcaaaa gtaagggcga       5040

gaaatattta caaactagag gtcacgaggt tgttgttgtt gacgatgaga ggtgtaaaaa       5100

gatcatgaaa caatttatcg atgaaagacc tcaggattgg tttgaagata ttggtgagta       5160

gctcgaaaac gcgtcgaccc atcgatggta ccagatccgg attagtccaa tttgttaaag       5220

acaggatatc agtggtccag gctctagttt tgactcaaca atatcaccag ctgaagccta       5280

tagagtacga gccatagata aaataaaaga ttttatttag tctccagaaa aaggggggaa       5340

tgaaagaccc cacctgtagg tttggcaagc tagcttaagt aacgccattt tgcaaggcat       5400

ggaaaaatac ataactgaga atagagaagt tcagatcaag gtcaggaaca gatggaacag       5460

ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc tcagggccaa       5520

gaacagatgg aacagctgaa tatgggccaa acaggatatc tgtggtaagc agttcctgcc       5580

ccggctcagg gccaagaaca gatggtcccc agatgcggtc cagccctcag cagtttctag       5640

agaaccatca gatgtttcca gggtgcccca aggacctgaa atgaccctgt gccttatttg       5700

aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc ttctgctccc cgagctcaat       5760

aaaagagccc acaacccctc actcggggcg ccagtcctcc gattgactga gtcgcccggg       5820

tacccgtgta tccaataaac cctcttgcag ttgcatccga cttgtggtct cgctgttcct       5880

tgggagggtc tcctctgagt gattgactac ccgtcagcgg gggtctttca cacatgcagc       5940

atgtatcaaa attaatttgg ttttttttct taagtattta cattaaatgg ccatagtact       6000

taaagttaca ttggcttcct tgaaataaac atggagtatt cagaatgtgt cataaatatt       6060

tctaatttta agatagtatc tccattggct ttctactttt tcttttattt ttttttgtcc       6120

tctgtcttcc atttgttgtt gttgttgttt gtttgtttgt ttgttggttg gttggttaat       6180

ttttttttaa agatcctaca ctatagttca agctagacta ttagctactc tgtaacccag       6240

ggtgaccttg aagtcatggg tagcctgctg ttttagcctt cccacatcta agattacagg       6300

tatgagctat catttttggt atatgattga ttgattgatt gatgtgtgtg tgtgtgattg       6360

tgtttgtgtg tgtgactgtg aaaatgtgtg tatgggtgtg tgtgaatgtg tgtatgtatg       6420

tgtgtgtgtg agtgtgtgtg tgtgtgtgtg catgtgtgtg tgtgtgactg tgtctatgtg       6480

tatgactgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttgtgaaa       6540

aaatattcta tggtagtgag agccaacgct ccggctcagg tgtcaggttg gtttttgaga       6600

cagagtcttt cacttagctt ggaattcact ggccgtcgtt ttacaacgtc gtgactggga       6660

aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg       6720

taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga       6780

atggcgcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg       6840

gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc       6900

aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc       6960

tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc       7020

gagacgaaag ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt       7080

ttcttagacg tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt       7140

tttctaaata cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca       7200

ataatattga aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt       7260

ttttgcggca ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga       7320

tgctgaagat cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa       7380

gatccttgag agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct       7440

gctatgtggc gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat       7500

acactattct cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga       7560

tggcatgaca gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc       7620

caacttactt ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat       7680

gggggatcat gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa       7740

cgacgagcgt gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac       7800

tggcgaacta cttactctag cttcccggca acaattaata gactggatgg aggcggataa       7860

agttgcagga ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc       7920

tggagccggt gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc       7980

ctcccgtatc gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag       8040

acagatcgct gagataggtg cctcactgat taagcattgg taactgtcag accaagttta       8100

ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa       8160

gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc       8220

gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat       8280

ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga       8340

gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt       8400

tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata       8460

cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac       8520

cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg       8580

ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg       8640

tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag       8700

cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct       8760

ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc       8820

aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt       8880

ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg       8940

tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga       9000

gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg       9060

gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg       9120

caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct       9180

tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta       9240

tgaccatgat tacgccaagc tttgctccta ggagtttcct aatacttccc aaactcaaat       9300

atataaagca tttgacttgt tctatgccct agggggcggg gggaagctaa gccagctttt       9360

tttaacattt aaaatgttaa ttccatttta aatgcacaga tgtttttatt tcataagggt       9420

ttcaatgtgc atgaatgctg caatattcct gttaccaaag ctagtataaa taaaaataga       9480

taaacgtgga aattacttag agtttctgtc attaacgttt ccttcctcag ttgacaacat       9540

aaatgcgctg ctgagcaagc cagtttgcat ctgtcaggat caatttccca ttatgccagt       9600

catattaatt actagtcaat tagttgattt ttatttttga catatacatg tgaatgaaag       9660

accccacctg taggtttggc aagctagctt aagt                                   9694


<210>    26
<211>    11162
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-TK:gag-pol vector


<400>    26
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcaacagga       8040

aagttccatt ggagccaagt acattgagtc aatagggact ttccaatggg ttttgcccag       8100

tacataaggt caatgggagg taagccaatg ggtttttccc attactggca cgtatactga       8160

gtcattaggg actttccaat gggttttgcc cagtacataa ggtcaatagg ggtgaatcaa       8220

caggaaagtc ccattggagc caagtacact gagtcaatag ggactttcca ttgggttttg       8280

cccagtacaa aaggtcaata gggggtgagt caatgggttt ttcccattat tggcacgtac       8340

ataaggtcaa taggggtgag tcattgggtt tttccagcca atttaattaa aacgccatgt       8400

actttcccac cattgacgtc aatgggctat tgaaactaat gcaacgtgac ctttaaacgg       8460

tactttccca tagctgatta atgggaaagt accgttctcg agccaataca cgtcaatggg       8520

aagtgaaagg gcagccaaaa cgtaacaccg ccccggtttt ccctggaaat tccatattgg       8580

cacgcattct attggctgag ctgcgttcta cgtgggtata agaggcgcga ccagcgtcgg       8640

taccgtcgca gtcttcggtc tgaccaccgt agaacgcaga gtttgatccg cgttaacatt       8700

tgcggccgct ttagtttcat ggcttcgtac ccctgccatc aacacgcgtc tgcgttcgac       8760

caggctgcgc gttctcgcgg ccatagcaac cgacgtacgg cgttgcgccc tcgccggcag       8820

caagaagcca cggaagtccg cctggagcag aaaatgccca cgctactgcg ggtttatata       8880

gacggtcctc acgggatggg gaaaaccacc accacgcaac tgctggtggc cctgggttcg       8940

cgcgacgata tcgtctacgt acccgagccg atgacttact ggcaggtgct gggggcttcc       9000

gagacaatcg cgaacatcta caccacacaa caccgcctcg accagggtga gatatcggcc       9060

ggggacgcgg cggtggtaat gacaagcgcc cagataacaa tgggcatgcc ttatgccgtg       9120

accgacgccg ttctggctcc tcatatcggg ggggaggctg ggagctcaca tgccccgccc       9180

ccggccctca ccctcatctt cgaccgccat cccatcgccg ccctcctgtg ctacccggcc       9240

gcgcgatacc ttatgggcag catgaccccc caggccgtgc tggcgttcgt ggccctcatc       9300

ccgccgacct tgcccggcac aaacatcgtg ttgggggccc ttccggagga cagacacatc       9360

gaccgcctgg ccaaacgcca gcgccccggc gagcggcttg acctggctat gctggccgcg       9420

attcgccgcg tttacgggct gcttgccaat acggtgcggt atctgcaggg cggcgggtcg       9480

tggcgggagg attggggaca gctttcgggg acggccgtgc cgccccaggg tgccgagccc       9540

cagagcaacg cgggcccacg accccatatc ggggacacgt tatttaccct gtttcgggcc       9600

cccgagttgc tggcccccaa cggcgacctg tacaacgtgt ttgcctgggc cttggacgtc       9660

ttggccaaac gcctccgtcc catgcacgtc tttatcctgg attacgacca atcgcccgcc       9720

ggctgccggg acgccctgct gcaacttacc tccgggatgg tccagaccca cgtcaccacc       9780

cccggctcca taccgacgat ctgcgacctg gcgcgcacgt ttgcccggga gatgggggag       9840

gctaactgaa acacggaagg ggtaccgaat tcctcgaaaa cgcgtcgaaa acgaattcat       9900

aaaataaaag attttatttt gtctccagaa aaagggggga atgaaagacc ccacctgtag       9960

gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaaata cataactgag      10020

aatagagaag ttcagatcaa ggtcaggaac agatggaaca gctgaatatg ggccaaacag      10080

gatagctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg gaacagctga      10140

atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac      10200

agatggtccc cagatgcggt ccagccctca gcagtttcta gagaaccatc agatgtttcc      10260

agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca atcagttcgc      10320

ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc cacaacccct      10380

cactcggggc gccagtcctc cgattgactg agtcgcccgg gtacccgtgt atccaataaa      10440

ccctcttgca gttgcatccg acttgtggtc tcgctgttcc ttgggagggt ctcctctgag      10500

tgattgacta cccgtcagcg ggggtctttc attgttactt aaagttacat tggcttcctt      10560

gaaataaaca tggagtattc agaatgtgtc ataaatattt ctaattttaa gatagtatct      10620

ccattggctt tctacttttt cttttatttt tttttgtcct ctgtcttcca tttgttgttg      10680

ttgttgtttg tttgtttgtt tgttggttgg ttggttaatt tttttttaaa gatcctacac      10740

tatagttcaa gctagactat tagctactct gtaacccagg gtgaccttga agtcatgggt      10800

agcctgctgt tttagccttc ccacatctaa gattacaggt atgagctatc atttttggta      10860

tattgattga ttgattgatt gatgtgtgtg tgtgtgattg tgtttgtgtg tgtgactgtg      10920

aaaatgtgtg tatgggtgtg tgtgaatgtg tgtatgtatg tgtgtgtgtg agtgtgtgtg      10980

tgtgtgtgtg catgtgtgtg tgtgtgactg tgtctatgtg tatgactgtg tgtgtgtgtg      11040

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgttgtgaaa aaatattcta tggtagtgag      11100

agccaacgct ccggctcagg tgtcaggttg gtttttgaga cagagtcttt cacttagctt      11160

gg                                                                     11162


<210>    27
<211>    10383
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-TK vector


<400>    27
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taattttgct ctaagattag agctattcac aagagaaatg gggaatcact agtgaattaa       3960

accgataagc gtttttttca ataacaggaa agtcccattg gagccaagta cattgagtca       4020

atagggactt tccaatgggt tttgcccagt acataaggtc aatgggaggt aagccaatgg       4080

gtttttccca ttactggcac gtatactgag tcattaggga ctttccaatg ggttttgccc       4140

agtacataag gtcaataggg gtgaatcaac aggaaagtcc cattggagcc aagtacactg       4200

agtcaatagg gactttccat tgggttttgc ccagtacaaa aggtcaatag ggggtgagtc       4260

aatgggtttt tcccattatt ggcacgtaca taaggtcaat aggggtgagt cattgggttt       4320

ttccagccaa tttaattaaa acgccatgta ctttcccacc attgacgtca atgggctatt       4380

gaaactaatg caacgtgacc tttaaacggt actttcccat agctgattaa tgggaaagta       4440

ccgttctcga gccaatacac gtcaatgggg aagtgaaagg gcagccaaac gtaacacgcc       4500

ccggtttccc ctggaaattc atattggcac gcattctatt ggctgagctg cgttctacgt       4560

gggtataaga ggcgcgacca gcgtcggtac cgtcgcagtc ttcggtctga ccaccgtaga       4620

acgcagaact ctagaactag tggatccgcg ttaacatttg cggccgcttt agtttcatgg       4680

cttcgtaccc ctgccatcaa cacgcgtctg cgttcgacca ggctgcgcgt tctcgcggcc       4740

atagcaaccg acgtacggcg ttgcgccctc gccggcagca agaagccacg gaagtccgcc       4800

tggagcagaa aatgcccacg ctactgcggg tttatataga cggtcctcac gggatgggga       4860

aaaccaccac cacgcaactg ctggtggccc tgggttcgcg cgacgatatc gtctacgtac       4920

ccgagccgat gacttactgg caggtgctgg gggcttccga gacaatcgcg aacatctaca       4980

ccacacaaca ccgcctcgac cagggtgaga tatcggccgg ggacgcggcg gtggtaatga       5040

caagcgccca gataacaatg ggcatgcctt atgccgtgac cgacgccgtt ctggctcctc       5100

atatcggggg ggaggctggg agctcacatg ccccgccccc ggccctcacc ctcatcttcg       5160

accgccatcc catcgccgcc ctcctgtgct acccggccgc gcgatacctt atgggcagca       5220

tgacccccca ggccgtgctg gcgttcgtgg ccctcatccc gccgaccttg cccggcacaa       5280

acatcgtgtt gggggccctt ccggaggaca gacacatcga ccgcctggcc aaacgccagc       5340

gccccggcga gcggcttgac ctggctatgc tggccgcgat tcgccgcgtt tacgggctgc       5400

ttgccattta cgggctgctt gccaatacgg tgcggtatct gcagggcggc gggtcgtggc       5460

gggaggattg gggacagctt tcggggacgg ccgtgccgcc ccagggtgcc gagccccaga       5520

gcaacgcggg cccacgaccc catatcgggg acacgttatt taccctgttt cgggcccccg       5580

agttgctggc ccccaacggc gacctgtaca acgtgtttgc ctgggccttg gacgtcttgg       5640

ccaaacgcct ccgtcccatg cacgtcttta tcctggatta cgaccaatcg cccgccggct       5700

gccgggacgc cctgctgcaa cttacctccg ggatggtcca gacccacgtc accacccccg       5760

gctccatacc gacgatctgc gacctggcgc gcacgtttgc ccgggagatg ggggaggcta       5820

actgaaacac ggaaggggta ccgaattcct cgaaaacgcg tcgacccatc gatggtacca       5880

gatccggatt agtccaattt gttaaagaca ggatatcagt ggtccaggct ctagttttga       5940

ctcaacaata tcaccagctg aagcctatag agtacgagcc atagataaaa taaaagattt       6000

tatttagtct ccagaaaaag gggggaatga aagaccccac ctgtaggttt ggcaagctag       6060

cttaagtaac gccattttgc aaggcatgga aaaatacata actgagaata ganaagttca       6120

gatcaaggtc aggaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa       6180

gcagttcctg ccccggctca gggccaagaa cagatggaac agctgaatat gggccaaaca       6240

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggtccccaga       6300

tgcggtccag ccctcagcag tttctagaga accatcagat gtttccaggg tgccccaagg       6360

acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt       6420

cgcgcgcttc tgctccccga gctcaataaa agagcccaca acccctcact cggggcgcca       6480

gtcctccgat tgactgagtc gcccgggtac ccgtgtatcc aataaaccct cttgcagttg       6540

catccgactt gtggtctcgc tgttccttgg gagggtctcc tctgagtgat tgactacccg       6600

tcagcggggg tctttcacac atgcagcatg tatcaaaatt aatttggttt tttttcttaa       6660

gtatttacat taaatggcca tagtacttaa agttacattg gcttccttga aataaacatg       6720

gagtattcag aatgtgtcat aaatatttct aattttaaga tagtatctcc attggctttc       6780

tactttttct tttatttttt tttgtcctct gtcttccatt tgttgttgtt gttgtttgtt       6840

tgtttgtttg ttggttggtt ggttaatttt tttttaaaga tcctacacta tagttcaagc       6900

tagactatta gctactctgt aacccagggt gaccttgaag tcatgggtag cctgctgttt       6960

tagccttccc acatctaaga ttacaggtat gagctatcat ttttggtata tgattgattg       7020

attgattgat gtgtgtgtgt gtgattgtgt ttgtgtgtgt gactgtgaaa atgtgtgtat       7080

gggtgtgtgt gaatgtgtgt atgtatgtgt gtgtgtgagt gtgtgtgtgt gtgtgtgcat       7140

gtgtgtgtgt gtgactgtgt ctatgtgtat gactgtgtgt gtgtgtgtgt gtgtgtgtgt       7200

gtgtgtgtgt gtgtgtgtgt tgtgaaaaaa tattctatgg tagtgagagc caacgctccg       7260

gctcaggtgt caggttggtt tttgagacag agtctttcac ttagcttgga attccractg       7320

gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt       7380

gcagcacatc cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct       7440

tcccaacagt tgcgcagcct gaatggcgaa tggcgcctga tgcggtattt tctccttacg       7500

catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg ctctgatgcc       7560

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt       7620

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag       7680

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt       7740

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga       7800

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc       7860

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt       7920

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct       7980

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt       8040

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt       8100

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac       8160

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac       8220

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct       8280

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg       8340

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg       8400

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca       8460

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa       8520

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt       8580

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc       8640

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg       8700

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt       8760

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt       8820

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc       8880

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct       8940

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta       9000

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc       9060

ttcagcagag cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac       9120

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct       9180

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat       9240

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg       9300

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa       9360

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg       9420

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga       9480

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc       9540

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct       9600

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct       9660

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca       9720

atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg       9780

tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat       9840

taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc       9900

ggataacaat ttcacacagg aaacagctat gaccatgatt acgccaagct ttgctcctag       9960

gagtttccta atacttccca aactcaaata tataaagcat ttgacttgtt ctatgcccta      10020

gggggcgggg ggaagctaag ccagcttttt ttaacattta aaatgttaat tccattttaa      10080

atgcacagat gtttttattt cataagggtt tcaatgtgca tgaatgctgc aatattcctg      10140

ttaccaaagc tagtataaat aaaaatagat aaacgtggaa attacttaga gtttctgtca      10200

ttaacgtttc cttcctcagt tgacaacata aatgcgctgc tgagcaagcc agtttgcatc      10260

tgtcaggatc aatttcccat tatgccagtc atattaatta ctagtcaatt agttgatttt      10320

tatttttgac atatacatgt gaatgaaaga ccccacctgt aggtttggca agctagctta      10380

agt                                                                    10383


<210>    28
<211>    9993
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-F1-TK vector


<400>    28
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taacacgtga aggctgccga ccccgggggt ggaccatcct ctagactgtg ctcgacgttt       3960

aaacgggtga atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact       4020

ttccattggg ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc       4080

attattggca cgtacataag gtcaataggg gtgagtcatt gggtttttcc agccaattta       4140

attaaaacgc catgtacttt cccaccattg acgtcaatgg gctattgaaa ctaatgcaac       4200

gtgaccttta aacggtactt tcccatagct gattaatggg aaagtaccgt tctcgagcca       4260

atacacgtca atgggaagtg aaagggcagc caaaacgtaa caccgccccg gttttccctg       4320

gaaattccat attggcacgc attctattgg ctgagctgcg ttcacgtggg tataagaggc       4380

gcgaccagcg tcggtaccgt cgcagtcttc ggtctgacca ccgtagaacg cagaacgcgt       4440

atggcttcgt acccctgcca tcaacacgcg tctgcgttcg accaggctgc gcgttctcgc       4500

ggccatagca accgacgtac ggcgttgcgc cctcgccggc agcaagaagc cacggaagtc       4560

cgcctggagc agaaaatgcc cacgctactg cgggtttata tagacggtcc tcacgggatg       4620

gggaaaacca ccaccacgca actgctggtg gccctgggtt cgcgcgacga tatcgtctac       4680

gtacccgagc cgatgactta ctggcaggtg ctgggggctt ccgagacaat cgcgaacatc       4740

tacaccacac aacaccgcct cgaccagggt gagatatcgg ccggggacgc ggcggtggta       4800

atgacaagcg cccagataac aatgggcatg ccttatgccg tgaccgacgc cgttctggct       4860

cctcatatcg ggggggaggc tgggagctca catgccccgc ccccggccct caccctcatc       4920

ttcgaccgcc atcccatcgc cgccctcctg tgctacccgg ccgcgcgata ccttatgggc       4980

agcatgaccc cccaggccgt gctggcgttc gtggccctca tcccgccgac cttgcccggc       5040

acaaacatcg tgttgggggc ccttccggag gacagacaca tcgaccgcct ggccaaacgc       5100

cagcgccccg gcgagcggct tgacctggct atgctggccg cgattcgccg cgtttacggg       5160

ctgcttgcca atacggtgcg gtatctgcag ggcggcgggt cgtggcggga ggattgggga       5220

cagctttcgg ggacggccgt gccgccccag ggtgccgagc cccagagcaa cgcgggccca       5280

cgaccccata tcggggacac gttatttacc ctgtttcggg cccccgagtt gctggccccc       5340

aacggcgacc tgtacaacgt gtttgcctgg gccttggacg tcttggccaa acgcctccgt       5400

cccatgcacg tctttatcct ggattacgac caatcgcccg ccggctgccg ggacgccctg       5460

ctgcaactta cctccgggat ggtccagacc cacgtcacca cccccggctc cataccgacg       5520

atctgcgacc tggcgcgcac gtttgcccgg gagatggggg aggctaactg agtcgacatc       5580

gatggtacca gatccgataa aataaaaggt tttatttagt ctcctgaaaa aggggggaat       5640

gaaagacccc acctgtaggt ttggcaagct agcttaagta acgccatttt gcaaggcatg       5700

gaaaaataca taactgagaa tagagaagtt cagatcaagg tcaggaacag atggaacagc       5760

tgaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag       5820

aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca gttcctgccc       5880

cggctcaggg ccaagaacag atggtcccca gatgcggtcc agccctcagc agtttctaga       5940

gaaccatcag atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga       6000

actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctcaata       6060

aaagagccca caacccctca ctcggggcgc cagtcctccg attgactgag tcgcccgggt       6120

acccgtgtat ccaataaacc ctcttgcagt tgcatccgac ttgtggtctc gctgttcctt       6180

gggagggtct cctctgagtg attgactacc cgtcagcggg ggtctttcac acatgcagca       6240

tgtatcaaaa ttaatttggt tttttttctt aagtatttac attaaatggc catagtactt       6300

aaagttacat tggcttcctt gaaataaaca tggagtattc agaatgtgtc ataaatattt       6360

ctaattttaa gatagtatct ccattggctt tctacttttt cttttatttt tttttgtcct       6420

ctgtcttcca tttgttgttg ttgttgtttg tttgtttgtt tgttggttgg ttggttaatt       6480

tttttttaaa gatcctacac tatagttcaa gctagactat tagctactct gtaacccagg       6540

gtgaccttga agtcatgggt agcctgctgt tttagccttc ccacatctaa gattacaggt       6600

atgagctatc atttttggta tatgattgat tgattgattg atgtgtgtgt gtgtgattgt       6660

gtttgtgtgt gtgactgtga aaatgtgtgt atgggtgtgt gtgaatgtgt gtatgtatgt       6720

gtgtgtgtga gtgtgtgtgt gtgtgtgtgc atgtgtgtgt gtgtgactgt gtctatgtgt       6780

atgactgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gttgtgaaaa       6840

aatattctat ggtagtgaga gccaacgctc cggctcaggt gtcaggttgg tttttgagac       6900

agagtctttc acttagcttg gaattcactg gccgtcgttt tacaacgtcg tgactgggaa       6960

aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt       7020

aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa       7080

tggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg       7140

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca       7200

acacccgctg acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct       7260

gtgaccgtct ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg       7320

agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt       7380

tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt       7440

ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa       7500

taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt       7560

tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat       7620

gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag       7680

atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg       7740

ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata       7800

cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat       7860

ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc       7920

aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg       7980

ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac       8040

gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact       8100

ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa       8160

gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct       8220

ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc       8280

tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga       8340

cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac       8400

tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag       8460

atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg       8520

tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc       8580

tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag       8640

ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt       8700

cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac       8760

ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc       8820

gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt       8880

tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt       8940

gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc       9000

ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt       9060

tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca       9120

ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt       9180

tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt       9240

attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag       9300

tcagtgagcg aggaagcgga agagcgccca atacgcaaac cgcctctccc cgcgcgttgg       9360

ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg cagtgagcgc       9420

aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca ctttatgctt       9480

ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat       9540

gaccatgatt acgccaagct ttgctcctag gagtttccta atacttccca aactcaaata       9600

tataaagcat ttgacttgtt ctatgcccta gggggcgggg ggaagctaag ccagcttttt       9660

ttaacattta aaatgttaat tccattttaa atgcacagat gtttttattt cataagggtt       9720

tcaatgtgca tgaatgctgc aatattcctg ttaccaaagc tagtataaat aaaaatagat       9780

aaacgtggaa attacttaga gtttctgtca ttaacgtttc cttcctcagt tgacaacata       9840

aatgcgctgc tgagcaagcc agtttgcatc tgtcaggatc aatttcccat tatgccagtc       9900

atattaatta ctagtcaatt agttgatttt tatttttgac atatacatgt gaatgaaaga       9960

ccccacctgt aggtttggca agctagctta agt                                    9993


<210>    29
<211>    9860
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-F2-TK vector


<400>    29
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taacacgtga aggctgccga ccccgggggt ggaccatcct ctagactgtg ctcgacgttt       3960

aaacaaggtc aataggggtg agtcattggg tttttccagc caatttaatt aaaacgccat       4020

gtactttccc accattgacg tcaatgggct attgaaacta atgcaacgtg acctttaaac       4080

ggtactttcc catagctgat taatgggaaa gtaccgttct cgagccaata cacgtcaatg       4140

ggaagtgaaa gggcagccaa aacgtaacac cgccccggtt ttccctggaa attccatatt       4200

ggcacgcatt ctattggctg agctgcgttc acgtgggtat aagaggcgcg accagcgtcg       4260

gtaccgtcgc agtcttcggt ctgaccaccg tagaacgcag aacgcgtatg gcttcgtacc       4320

cctgccatca acacgcgtct gcgttcgacc aggctgcgcg ttctcgcggc catagcaacc       4380

gacgtacggc gttgcgccct cgccggcagc aagaagccac ggaagtccgc ctggagcaga       4440

aaatgcccac gctactgcgg gtttatatag acggtcctca cgggatgggg aaaaccacca       4500

ccacgcaact gctggtggcc ctgggttcgc gcgacgatat cgtctacgta cccgagccga       4560

tgacttactg gcaggtgctg ggggcttccg agacaatcgc gaacatctac accacacaac       4620

accgcctcga ccagggtgag atatcggccg gggacgcggc ggtggtaatg acaagcgccc       4680

agataacaat gggcatgcct tatgccgtga ccgacgccgt tctggctcct catatcgggg       4740

gggaggctgg gagctcacat gccccgcccc cggccctcac cctcatcttc gaccgccatc       4800

ccatcgccgc cctcctgtgc tacccggccg cgcgatacct tatgggcagc atgacccccc       4860

aggccgtgct ggcgttcgtg gccctcatcc cgccgacctt gcccggcaca aacatcgtgt       4920

tgggggccct tccggaggac agacacatcg accgcctggc caaacgccag cgccccggcg       4980

agcggcttga cctggctatg ctggccgcga ttcgccgcgt ttacgggctg cttgccaata       5040

cggtgcggta tctgcagggc ggcgggtcgt ggcgggagga ttggggacag ctttcgggga       5100

cggccgtgcc gccccagggt gccgagcccc agagcaacgc gggcccacga ccccatatcg       5160

gggacacgtt atttaccctg tttcgggccc ccgagttgct ggcccccaac ggcgacctgt       5220

acaacgtgtt tgcctgggcc ttggacgtct tggccaaacg cctccgtccc atgcacgtct       5280

ttatcctgga ttacgaccaa tcgcccgccg gctgccggga cgccctgctg caacttacct       5340

ccgggatggt ccagacccac gtcaccaccc ccggctccat accgacgatc tgcgacctgg       5400

cgcgcacgtt tgcccgggag atgggggagg ctaactgagt cgacatcgat ggtaccagat       5460

ccgataaaat aaaaggtttt atttagtctc ctgaaaaagg ggggaatgaa agaccccacc       5520

tgtaggtttg gcaagctagc ttaagtaacg ccattttgca aggcatggaa aaatacataa       5580

ctgagaatag agaagttcag atcaaggtca ggaacagatg gaacagctga atatgggcca       5640

aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggaaca       5700

gctgaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca       5760

agaacagatg gtccccagat gcggtccagc cctcagcagt ttctagagaa ccatcagatg       5820

tttccagggt gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag       5880

ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa       5940

cccctcactc ggggcgccag tcctccgatt gactgagtcg cccgggtacc cgtgtatcca       6000

ataaaccctc ttgcagttgc atccgacttg tggtctcgct gttccttggg agggtctcct       6060

ctgagtgatt gactacccgt cagcgggggt ctttcacaca tgcagcatgt atcaaaatta       6120

atttggtttt ttttcttaag tatttacatt aaatggccat agtacttaaa gttacattgg       6180

cttccttgaa ataaacatgg agtattcaga atgtgtcata aatatttcta attttaagat       6240

agtatctcca ttggctttct actttttctt ttattttttt ttgtcctctg tcttccattt       6300

gttgttgttg ttgtttgttt gtttgtttgt tggttggttg gttaattttt ttttaaagat       6360

cctacactat agttcaagct agactattag ctactctgta acccagggtg accttgaagt       6420

catgggtagc ctgctgtttt agccttccca catctaagat tacaggtatg agctatcatt       6480

tttggtatat gattgattga ttgattgatg tgtgtgtgtg tgattgtgtt tgtgtgtgtg       6540

actgtgaaaa tgtgtgtatg ggtgtgtgtg aatgtgtgta tgtatgtgtg tgtgtgagtg       6600

tgtgtgtgtg tgtgtgcatg tgtgtgtgtg tgactgtgtc tatgtgtatg actgtgtgtg       6660

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt gtgaaaaaat attctatggt       6720

agtgagagcc aacgctccgg ctcaggtgtc aggttggttt ttgagacaga gtctttcact       6780

tagcttggaa ttcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta       6840

cccaacttaa tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg       6900

cccgcaccga tcgcccttcc caacagttgc gcagcctgaa tggcgaatgg cgcctgatgc       6960

ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatggtgc actctcagta       7020

caatctgctc tgatgccgca tagttaagcc agccccgaca cccgccaaca cccgctgacg       7080

cgccctgacg ggcttgtctg ctcccggcat ccgcttacag acaagctgtg accgtctccg       7140

ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa acgcgcgaga cgaaagggcc       7200

tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct tagacgtcag       7260

gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt       7320

caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa tattgaaaaa       7380

ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt gcggcatttt       7440

gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt       7500

tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc cttgagagtt       7560

ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta tgtggcgcgg       7620

tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac tattctcaga       7680

atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc atgacagtaa       7740

gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac ttacttctga       7800

caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg gatcatgtaa       7860

ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac gagcgtgaca       7920

ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc gaactactta       7980

ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt gcaggaccac       8040

ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga gccggtgagc       8100

gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc cgtatcgtag       8160

ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag atcgctgaga       8220

taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca tatatacttt       8280

agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc ctttttgata       8340

atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca gaccccgtag       8400

aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa       8460

caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta ccaactcttt       8520

ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgttctt ctagtgtagc       8580

cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc gctctgctaa       8640

tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg ttggactcaa       8700

gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg tgcacacagc       8760

ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag ctatgagaaa       8820

gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa       8880

caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat agtcctgtcg       8940

ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc       9000

tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc tggccttttg       9060

ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt accgcctttg       9120

agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg       9180

aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat       9240

gcagctggca cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg       9300

tgagttagct cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt       9360

tgtgtggaat tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg       9420

ccaagctttg ctcctaggag tttcctaata cttcccaaac tcaaatatat aaagcatttg       9480

acttgttcta tgccctaggg ggcgggggga agctaagcca gcttttttta acatttaaaa       9540

tgttaattcc attttaaatg cacagatgtt tttatttcat aagggtttca atgtgcatga       9600

atgctgcaat attcctgtta ccaaagctag tataaataaa aatagataaa cgtggaaatt       9660

acttagagtt tctgtcatta acgtttcctt cctcagttga caacataaat gcgctgctga       9720

gcaagccagt ttgcatctgt caggatcaat ttcccattat gccagtcata ttaattacta       9780

gtcaattagt tgatttttat ttttgacata tacatgtgaa tgaaagaccc cacctgtagg       9840

tttggcaagc tagcttaagt                                                   9860


<210>    30
<211>    9760
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-F3-TK vector


<400>    30
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taacacgtga aggctgccga ccccgggggt ggaccatcct ctagactgtg ctcgacgttt       3960

aaacaacgtg acctttaaac ggtactttcc catagctgat taatgggaaa gtaccgttct       4020

cgagccaata cacgtcaatg ggaagtgaaa gggcagccaa aacgtaacac cgccccggtt       4080

ttccctggaa attccatatt ggcacgcatt ctattggctg agctgcgttc acgtgggtat       4140

aagaggcgcg accagcgtcg gtaccgtcgc agtcttcggt ctgaccaccg tagaacgcag       4200

aacgcgtatg gcttcgtacc cctgccatca acacgcgtct gcgttcgacc aggctgcgcg       4260

ttctcgcggc catagcaacc gacgtacggc gttgcgccct cgccggcagc aagaagccac       4320

ggaagtccgc ctggagcaga aaatgcccac gctactgcgg gtttatatag acggtcctca       4380

cgggatgggg aaaaccacca ccacgcaact gctggtggcc ctgggttcgc gcgacgatat       4440

cgtctacgta cccgagccga tgacttactg gcaggtgctg ggggcttccg agacaatcgc       4500

gaacatctac accacacaac accgcctcga ccagggtgag atatcggccg gggacgcggc       4560

ggtggtaatg acaagcgccc agataacaat gggcatgcct tatgccgtga ccgacgccgt       4620

tctggctcct catatcgggg gggaggctgg gagctcacat gccccgcccc cggccctcac       4680

cctcatcttc gaccgccatc ccatcgccgc cctcctgtgc tacccggccg cgcgatacct       4740

tatgggcagc atgacccccc aggccgtgct ggcgttcgtg gccctcatcc cgccgacctt       4800

gcccggcaca aacatcgtgt tgggggccct tccggaggac agacacatcg accgcctggc       4860

caaacgccag cgccccggcg agcggcttga cctggctatg ctggccgcga ttcgccgcgt       4920

ttacgggctg cttgccaata cggtgcggta tctgcagggc ggcgggtcgt ggcgggagga       4980

ttggggacag ctttcgggga cggccgtgcc gccccagggt gccgagcccc agagcaacgc       5040

gggcccacga ccccatatcg gggacacgtt atttaccctg tttcgggccc ccgagttgct       5100

ggcccccaac ggcgacctgt acaacgtgtt tgcctgggcc ttggacgtct tggccaaacg       5160

cctccgtccc atgcacgtct ttatcctgga ttacgaccaa tcgcccgccg gctgccggga       5220

cgccctgctg caacttacct ccgggatggt ccagacccac gtcaccaccc ccggctccat       5280

accgacgatc tgcgacctgg cgcgcacgtt tgcccgggag atgggggagg ctaactgagt       5340

cgacatcgat ggtaccagat ccgataaaat aaaaggtttt atttagtctc ctgaaaaagg       5400

ggggaatgaa agaccccacc tgtaggtttg gcaagctagc ttaagtaacg ccattttgca       5460

aggcatggaa aaatacataa ctgagaatag agaagttcag atcaaggtca ggaacagatg       5520

gaacagctga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag       5580

ggccaagaac agatggaaca gctgaatatg ggccaaacag gatatctgtg gtaagcagtt       5640

cctgccccgg ctcagggcca agaacagatg gtccccagat gcggtccagc cctcagcagt       5700

ttctagagaa ccatcagatg tttccagggt gccccaagga cctgaaatga ccctgtgcct       5760

tatttgaact aaccaatcag ttcgcttctc gcttctgttc gcgcgcttct gctccccgag       5820

ctcaataaaa gagcccacaa cccctcactc ggggcgccag tcctccgatt gactgagtcg       5880

cccgggtacc cgtgtatcca ataaaccctc ttgcagttgc atccgacttg tggtctcgct       5940

gttccttggg agggtctcct ctgagtgatt gactacccgt cagcgggggt ctttcacaca       6000

tgcagcatgt atcaaaatta atttggtttt ttttcttaag tatttacatt aaatggccat       6060

agtacttaaa gttacattgg cttccttgaa ataaacatgg agtattcaga atgtgtcata       6120

aatatttcta attttaagat agtatctcca ttggctttct actttttctt ttattttttt       6180

ttgtcctctg tcttccattt gttgttgttg ttgtttgttt gtttgtttgt tggttggttg       6240

gttaattttt ttttaaagat cctacactat agttcaagct agactattag ctactctgta       6300

acccagggtg accttgaagt catgggtagc ctgctgtttt agccttccca catctaagat       6360

tacaggtatg agctatcatt tttggtatat gattgattga ttgattgatg tgtgtgtgtg       6420

tgattgtgtt tgtgtgtgtg actgtgaaaa tgtgtgtatg ggtgtgtgtg aatgtgtgta       6480

tgtatgtgtg tgtgtgagtg tgtgtgtgtg tgtgtgcatg tgtgtgtgtg tgactgtgtc       6540

tatgtgtatg actgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt       6600

gtgaaaaaat attctatggt agtgagagcc aacgctccgg ctcaggtgtc aggttggttt       6660

ttgagacaga gtctttcact tagcttggaa ttcactggcc gtcgttttac aacgtcgtga       6720

ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc ctttcgccag       6780

ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa       6840

tggcgaatgg cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg       6900

catatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agccccgaca       6960

cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat ccgcttacag       7020

acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt catcaccgaa       7080

acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat       7140

aatggtttct tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg       7200

tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat       7260

gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat       7320

tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt       7380

aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag       7440

cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa       7500

agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg       7560

ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct       7620

tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac       7680

tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca       7740

caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat       7800

accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact       7860

attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc       7920

ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga       7980

taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg       8040

taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg       8100

aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca       8160

agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta       8220

ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca       8280

ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg       8340

cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga       8400

tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa       8460

tactgttctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc       8520

tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg       8580

tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac       8640

ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct       8700

acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc       8760

ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg       8820

gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg       8880

ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct       8940

ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga       9000

taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg       9060

cagcgagtca gtgagcgagg aagcggaaga gcgcccaata cgcaaaccgc ctctccccgc       9120

gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag       9180

tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt       9240

tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa       9300

cagctatgac catgattacg ccaagctttg ctcctaggag tttcctaata cttcccaaac       9360

tcaaatatat aaagcatttg acttgttcta tgccctaggg ggcgggggga agctaagcca       9420

gcttttttta acatttaaaa tgttaattcc attttaaatg cacagatgtt tttatttcat       9480

aagggtttca atgtgcatga atgctgcaat attcctgtta ccaaagctag tataaataaa       9540

aatagataaa cgtggaaatt acttagagtt tctgtcatta acgtttcctt cctcagttga       9600

caacataaat gcgctgctga gcaagccagt ttgcatctgt caggatcaat ttcccattat       9660

gccagtcata ttaattacta gtcaattagt tgatttttat ttttgacata tacatgtgaa       9720

tgaaagaccc cacctgtagg tttggcaagc tagcttaagt                             9760


<210>    31
<211>    9685
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-F4-TK vector


<400>    31
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taacacgtga aggctgccga ccccgggggt ggaccatcct ctagactgtg ctcgacgttt       3960

aaacggaagt gaaagggcag ccaaaacgta acaccgcccc ggttttccct ggaaattcca       4020

tattggcacg cattctattg gctgagctgc gttcacgtgg gtataagagg cgcgaccagc       4080

gtcggtaccg tcgcagtctt cggtctgacc accgtagaac gcagaggatc ctatggcttc       4140

gtacccctgc catcaacacg cgtctgcgtt cgaccaggct gcgcgttctc gcggccatag       4200

caaccgacgt acggcgttgc gccctcgccg gcagcaagaa gccacggaag tccgcctgga       4260

gcagaaaatg cccacgctac tgcgggttta tatagacggt cctcacggga tggggaaaac       4320

caccaccacg caactgctgg tggccctggg ttcgcgcgac gatatcgtct acgtacccga       4380

gccgatgact tactggcagg tgctgggggc ttccgagaca atcgcgaaca tctacaccac       4440

acaacaccgc ctcgaccagg gtgagatatc ggccggggac gcggcggtgg taatgacaag       4500

cgcccagata acaatgggca tgccttatgc cgtgaccgac gccgttctgg ctcctcatat       4560

cgggggggag gctgggagct cacatgcccc gcccccggcc ctcaccctca tcttcgaccg       4620

ccatcccatc gccgccctcc tgtgctaccc ggccgcgcga taccttatgg gcagcatgac       4680

cccccaggcc gtgctggcgt tcgtggccct catcccgccg accttgcccg gcacaaacat       4740

cgtgttgggg gcccttccgg aggacagaca catcgaccgc ctggccaaac gccagcgccc       4800

cggcgagcgg cttgacctgg ctatgctggc cgcgattcgc cgcgtttacg ggctgcttgc       4860

caatacggtg cggtatctgc agggcggcgg gtcgtggcgg gaggattggg gacagctttc       4920

ggggacggcc gtgccgcccc agggtgccga gccccagagc aacgcgggcc cacgacccca       4980

tatcggggac acgttattta ccctgtttcg ggcccccgag ttgctggccc ccaacggcga       5040

cctgtacaac gtgtttgcct gggccttgga cgtcttggcc aaacgcctcc gtcccatgca       5100

cgtctttatc ctggattacg accaatcgcc cgccggctgc cgggacgccc tgctgcaact       5160

tacctccggg atggtccaga cccacgtcac cacccccggc tccataccga cgatctgcga       5220

cctggcgcgc acgtttgccc gggagatggg ggaggctaac tgagtcgaca tcgatggtac       5280

cagatccgat aaaataaaag gttttattta gtctcctgaa aaagggggga atgaaagacc       5340

ccacctgtag gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaaata       5400

cataactgag aatagagaag ttcagatcaa ggtcaggaac agatggaaca gctgaatatg       5460

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg       5520

gaacagctga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag       5580

ggccaagaac agatggtccc cagatgcggt ccagccctca gcagtttcta gagaaccatc       5640

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca       5700

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc       5760

cacaacccct cactcggggc gccagtcctc cgattgactg agtcgcccgg gtacccgtgt       5820

atccaataaa ccctcttgca gttgcatccg acttgtggtc tcgctgttcc ttgggagggt       5880

ctcctctgag tgattgacta cccgtcagcg ggggtctttc acacatgcag catgtatcaa       5940

aattaatttg gttttttttc ttaagtattt acattaaatg gccatagtac ttaaagttac       6000

attggcttcc ttgaaataaa catggagtat tcagaatgtg tcataaatat ttctaatttt       6060

aagatagtat ctccattggc tttctacttt ttcttttatt tttttttgtc ctctgtcttc       6120

catttgttgt tgttgttgtt tgtttgtttg tttgttggtt ggttggttaa ttttttttta       6180

aagatcctac actatagttc aagctagact attagctact ctgtaaccca gggtgacctt       6240

gaagtcatgg gtagcctgct gttttagcct tcccacatct aagattacag gtatgagcta       6300

tcatttttgg tatatgattg attgattgat tgatgtgtgt gtgtgtgatt gtgtttgtgt       6360

gtgtgactgt gaaaatgtgt gtatgggtgt gtgtgaatgt gtgtatgtat gtgtgtgtgt       6420

gagtgtgtgt gtgtgtgtgt gcatgtgtgt gtgtgtgact gtgtctatgt gtatgactgt       6480

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgtgaa aaaatattct       6540

atggtagtga gagccaacgc tccggctcag gtgtcaggtt ggtttttgag acagagtctt       6600

tcacttagct tggaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg       6660

cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga       6720

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggcgcct       6780

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct       6840

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc       6900

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt       6960

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa       7020

gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac       7080

gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat       7140

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg       7200

aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc       7260

attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga       7320

tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga       7380

gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg       7440

cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc       7500

tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac       7560

agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact       7620

tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca       7680

tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg       7740

tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact       7800

acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg       7860

accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg       7920

tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat       7980

cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc       8040

tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat       8100

actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt       8160

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc       8220

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt       8280

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac       8340

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt       8400

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct       8460

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga       8520

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac       8580

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg       8640

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt       8700

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc       8760

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg       8820

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc       8880

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc       8940

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag       9000

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca       9060

ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat       9120

taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg       9180

tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga       9240

ttacgccaag ctttgctcct aggagtttcc taatacttcc caaactcaaa tatataaagc       9300

atttgacttg ttctatgccc tagggggcgg ggggaagcta agccagcttt ttttaacatt       9360

taaaatgtta attccatttt aaatgcacag atgtttttat ttcataaggg tttcaatgtg       9420

catgaatgct gcaatattcc tgttaccaaa gctagtataa ataaaaatag ataaacgtgg       9480

aaattactta gagtttctgt cattaacgtt tccttcctca gttgacaaca taaatgcgct       9540

gctgagcaag ccagtttgca tctgtcagga tcaatttccc attatgccag tcatattaat       9600

tactagtcaa ttagttgatt tttatttttg acatatacat gtgaatgaaa gaccccacct       9660

gtaggtttgg caagctagct taagt                                             9685


<210>    32
<211>    10008
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-sEF1a-hopt-yCD


<400>    32
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcgggcaga       8040

gcgcacatcg cccgcagtcc ccgagaagtt ggggggaggg gtcggcaatt gatccggtgc       8100

ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt       8160

tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg       8220

caacgggttt gccgccagaa cacaggcggc cgcatggtta ctgggggaat ggcatctaag       8280

tgggatcaga aaggtatgga catcgcttat gaagaggctg ctctcggcta caaagagggt       8340

ggagtgccta tcggagggtg cctgatcaac aacaaggacg gcagtgtgct ggggaggggc       8400

cacaatatga ggttccaaaa aggctccgcc actctccacg gggaaattag taccctcgag       8460

aattgcggac gattggaagg gaaggtgtac aaggatacaa cactgtacac caccctgtca       8520

ccctgtgata tgtgcacagg cgccattatc atgtacggaa tccctagatg tgtcgtgggg       8580

gagaatgtaa acttcaaaag taagggggag aaatatctcc agacccgggg gcacgaagtc       8640

gtcgttgtgg acgatgaacg gtgtaagaag atcatgaagc agtttatcga tgagaggccc       8700

caggactggt tcgaagacat cggggaataa gtttaaacga attcataaaa taaaagattt       8760

tatttagtct ccagaaaaag gggggaatga aagaccccac ctgtaggttt ggcaagctag       8820

cttaagtaac gccattttgc aaggcatgga aaaatacata actgagaata gagaagttca       8880

gatcaaggtc aggaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa       8940

gcagttcctg ccccggctca gggccaagaa cagatggaac agctgaatat gggccaaaca       9000

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggtccccaga       9060

tgcggtccag ccctcagcag tttctagaga accatcagat gtttccaggg tgccccaagg       9120

acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt       9180

cgcgcgcttc tgctccccga gctcaataaa agagcccaca acccctcact cggggcgcca       9240

gtcctccgat tgactgagtc gcccgggtac ccgtgtatcc aataaaccct cttgcagttg       9300

catccgactt gtggtctcgc tgttccttgg gagggtctcc tctgagtgat tgactacccg       9360

tcagcggggg tctttcattg ttacttaaag ttacattggc ttccttgaaa taaacatgga       9420

gtattcagaa tgtgtcataa atatttctaa ttttaagata gtatctccat tggctttcta       9480

ctttttcttt tatttttttt tgtcctctgt cttccatttg ttgttgttgt tgtttgtttg       9540

tttgtttgtt ggttggttgg ttaatttttt tttaaagatc ctacactata gttcaagcta       9600

gactattagc tactctgtaa cccagggtga ccttgaagtc atgggtagcc tgctgtttta       9660

gccttcccac atctaagatt acaggtatga gctatcattt ttggtatatt gattgattga       9720

ttgattgatg tgtgtgtgtg tgattgtgtt tgtgtgtgtg actgtgaaaa tgtgtgtatg       9780

ggtgtgtgtg aatgtgtgta tgtatgtgtg tgtgtgagtg tgtgtgtgtg tgtgtgcatg       9840

tgtgtgtgtg tgactgtgtc tatgtgtatg actgtgtgtg tgtgtgtgtg tgtgtgtgtg       9900

tgtgtgtgtg tgtgtgtgtt gtgaaaaaat attctatggt agtgagagcc aacgctccgg       9960

ctcaggtgtc aggttggttt ttgagacaga gtctttcact tagcttgg                   10008


<210>    33
<211>    10108
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVe-TK vector


<400>    33
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacgtgat       1800

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat       1860

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt       1920

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg       1980

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga       2040

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag       2100

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg       2160

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta       2220

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga       2280

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc       2340

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc       2400

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg       2460

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt       2520

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat       2580

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag       2640

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga       2700

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa       2760

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt       2820

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca       2880

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac       2940

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc       3000

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt       3060

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca       3120

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt       3180

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat       3240

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat       3300

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc       3360

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg       3420

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt       3480

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac       3540

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc       3600

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct       3660

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac       3720

tcaacaatat caccagctga agcctataga gtacgagcca tagcacgtga aggctgccga       3780

ccccgggggt ggacatcctc tagactgcca tggcgcggat ctcgacgttt aaacaacagg       3840

aaagttccat tggagccaag tacattgagt caatagggac tttccaatgg gttttgccca       3900

gtacataagg tcaatgggag gtaagccaat gggtttttcc cattactggc acgtatactg       3960

agtcattagg gactttccaa tgggttttgc ccagtacata aggtcaatag gggtgaatca       4020

acaggaaagt cccattggag ccaagtacac tgagtcaata gggactttcc attgggtttt       4080

gcccagtaca aaaggtcaat agggggtgag tcaatgggtt tttcccatta ttggcacgta       4140

cataaggtca ataggggtga gtcattgggt ttttccagcc aatttaatta aaacgccatg       4200

tactttccca ccattgacgt caatgggcta ttgaaactaa tgcaacgtga cctttaaacg       4260

gtactttccc atagctgatt aatgggaaag taccgttctc gagccaatac acgtcaatgg       4320

gaagtgaaag ggcagccaaa acgtaacacc gccccggttt tccctggaaa ttccatattg       4380

gcacgcattc tattggctga gctgcgttct acgtgggtat aagaggcgcg accagcgtcg       4440

gtaccgtcgc agtcttcggt ctgaccaccg tagaacgcag aactctagaa ctagtggatc       4500

cgttaacatt tgcggccgct ttagtttatg gtgacatggc ttcgtacccc tgccatcaac       4560

acgcgtctgc gttcgaccag gctgcgcgtt ctcgcggcca tagcaaccga cgtacggcgt       4620

tgcgccctcg ccggcagcaa gaagccacgg aagtccgcct ggagcagaaa atgcccacgc       4680

tactgcgggt ttatatagac ggtcctcacg ggatggggaa aaccaccacc acgcaactgc       4740

tggtggccct gggttcgcgc gacgatatcg tctacgtacc cgagccgatg acttactggc       4800

aggtgctggg ggcttccgag acaatcgcga acatctacac cacacaacac cgcctcgacc       4860

agggtgagat atcggccggg gacgcggcgg tggtaatgac aagcgcccag ataacaatgg       4920

gcatgcctta tgccgtgacc gacgccgttc tggctcctca tatcgggggg gaggctggga       4980

gctcacatgc cccgcccccg gccctcaccc tcatcttcga ccgccatccc atcgccgccc       5040

tcctgtgcta cccggccgcg cgatacctta tgggcagcat gaccccccag gccgtgctgg       5100

cgttcgtggc cctcatcccg ccgaccttgc ccggcacaaa catcgtgttg ggggcccttc       5160

cggaggacag acacatcgac cgcctggcca aacgccagcg ccccggcgag cggcttgacc       5220

tggctatgct ggccgcgatt cgccgcgttt acgggctgct tgccaatacg gtgcggtatc       5280

tgcagggcgg cgggtcgtgg cgggaggatt ggggacagct ttcggggacg gccgtgccgc       5340

cccagggtgc cgagccccag agcaacgcgg gcccacgacc ccatatcggg gacacgttat       5400

ttaccctgtt tcgggccccc gagttgctgg cccccaacgg cgacctgtac aacgtgtttg       5460

cctgggcctt ggacgtcttg gccaaacgcc tccgtcccat gcacgtcttt atcctggatt       5520

acgaccaatc gcccgccggc tgccgggacg ccctgctgca acttacctcc gggatggtcc       5580

agacccacgt caccaccccc ggctccatac cgacgatctg cgacctggcg cgcacgtttg       5640

cccgggagat gggggaggct aactgatcga gaaacgcgtc gacccatcga acatcgatgg       5700

taccagatcc gataaaataa aagattttat ttagtctcca gaaaaagggg ggaatgaaag       5760

accccacctg taggtttggc aagctagctt aagtaacgcc attttgcaag gcatggaaaa       5820

atacataact gagaatagag aagttcagat caaggtcagg aacagatgga acagctgaat       5880

atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg ccaagaacag       5940

atggaacagc tgaatatggg ccaaacagga tatctgtggt aagcagttcc tgccccggct       6000

cagggccaag aacagatggt ccccagatgc ggtccagccc tcagcagttt ctagagaacc       6060

atcagatgtt tccagggtgc cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa       6120

ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc tccccgagct caataaaaga       6180

gcccacaacc cctcactcgg ggcgccagtc ctccgattga ctgagtcgcc cgggtacccg       6240

tgtatccaat aaaccctctt gcagttgcat ccgacttgtg gtctcgctgt tccttgggag       6300

ggtctcctct gagtgattga ctacccgtca gcgggggtct ttcacacatg cagcatgtat       6360

caaaattaat ttggtttttt ttcttaagta tttacattaa atggccatag tacttaaagt       6420

tacattggct tccttgaaat aaacatggag tattcagaat gtgtcataaa tatttctaat       6480

tttaagatag tatctccatt ggctttctac tttttctttt attttttttt gtcctctgtc       6540

ttccatttgt tgttgttgtt gtttgtttgt ttgtttgttg gttggttggt taattttttt       6600

ttaaagatcc tacactatag ttcaagctag actattagct actctgtaac ccagggtgac       6660

cttgaagtca tgggtagcct gctgttttag ccttcccaca tctaagatta caggtatgag       6720

ctatcatttt tggtatatga ttgattgatt gattgatgtg tgtgtgtgtg attgtgtttg       6780

tgtgtgtgac tgtgaaaatg tgtgtatggg tgtgtgtgaa tgtgtgtatg tatgtgtgtg       6840

tgtgagtgtg tgtgtgtgtg tgtgcatgtg tgtgtgtgtg actgtgtcta tgtgtatgac       6900

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgt gaaaaaatat       6960

tctatggtag tgagagccaa cgctccggct caggtgtcag gttggttttt gagacagagt       7020

ctttcactta gcttggaatt cactggccgt cgttttacaa cgtcgtgact gggaaaaccc       7080

tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct ggcgtaatag       7140

cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatggcg       7200

cctgatgcgg tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatggtgcac       7260

tctcagtaca atctgctctg atgccgcata gttaagccag ccccgacacc cgccaacacc       7320

cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac aagctgtgac       7380

cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg       7440

aaagggcctc gtgatacgcc tatttttata ggttaatgtc atgataataa tggtttctta       7500

gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc cctatttgtt tatttttcta       7560

aatacattca aatatgtatc cgctcatgag acaataaccc tgataaatgc ttcaataata       7620

ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc gcccttattc ccttttttgc       7680

ggcattttgc cttcctgttt ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga       7740

agatcagttg ggtgcacgag tgggttacat cgaactggat ctcaacagcg gtaagatcct       7800

tgagagtttt cgccccgaag aacgttttcc aatgatgagc acttttaaag ttctgctatg       7860

tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta       7920

ttctcagaat gacttggttg agtactcacc agtcacagaa aagcatctta cggatggcat       7980

gacagtaaga gaattatgca gtgctgccat aaccatgagt gataacactg cggccaactt       8040

acttctgaca acgatcggag gaccgaagga gctaaccgct tttttgcaca acatggggga       8100

tcatgtaact cgccttgatc gttgggaacc ggagctgaat gaagccatac caaacgacga       8160

gcgtgacacc acgatgcctg tagcaatggc aacaacgttg cgcaaactat taactggcga       8220

actacttact ctagcttccc ggcaacaatt aatagactgg atggaggcgg ataaagttgc       8280

aggaccactt ctgcgctcgg cccttccggc tggctggttt attgctgata aatctggagc       8340

cggtgagcgt gggtctcgcg gtatcattgc agcactgggg ccagatggta agccctcccg       8400

tatcgtagtt atctacacga cggggagtca ggcaactatg gatgaacgaa atagacagat       8460

cgctgagata ggtgcctcac tgattaagca ttggtaactg tcagaccaag tttactcata       8520

tatactttag attgatttaa aacttcattt ttaatttaaa aggatctagg tgaagatcct       8580

ttttgataat ctcatgacca aaatccctta acgtgagttt tcgttccact gagcgtcaga       8640

ccccgtagaa aagatcaaag gatcttcttg agatcctttt tttctgcgcg taatctgctg       8700

cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt ttgccggatc aagagctacc       8760

aactcttttt ccgaaggtaa ctggcttcag cagagcgcag ataccaaata ctgttcttct       8820

agtgtagccg tagttaggcc accacttcaa gaactctgta gcaccgccta catacctcgc       8880

tctgctaatc ctgttaccag tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt       8940

ggactcaaga cgatagttac cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg       9000

cacacagccc agcttggagc gaacgaccta caccgaactg agatacctac agcgtgagct       9060

atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg taagcggcag       9120

ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt atctttatag       9180

tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg       9240

gcggagccta tggaaaaacg ccagcaacgc ggccttttta cggttcctgg ccttttgctg       9300

gccttttgct cacatgttct ttcctgcgtt atcccctgat tctgtggata accgtattac       9360

cgcctttgag tgagctgata ccgctcgccg cagccgaacg accgagcgca gcgagtcagt       9420

gagcgaggaa gcggaagagc gcccaatacg caaaccgcct ctccccgcgc gttggccgat       9480

tcattaatgc agctggcacg acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc       9540

aattaatgtg agttagctca ctcattaggc accccaggct ttacacttta tgcttccggc       9600

tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca gctatgacca       9660

tgattacgcc aagctttgct cctaggagtt tcctaatact tcccaaactc aaatatataa       9720

agcatttgac ttgttctatg ccctaggggg cggggggaag ctaagccagc tttttttaac       9780

atttaaaatg ttaattccat tttaaatgca cagatgtttt tatttcataa gggtttcaat       9840

gtgcatgaat gctgcaatat tcctgttacc aaagctagta taaataaaaa tagataaacg       9900

tggaaattac ttagagtttc tgtcattaac gtttccttcc tcagttgaca acataaatgc       9960

gctgctgagc aagccagttt gcatctgtca ggatcaattt cccattatgc cagtcatatt      10020

aattactagt caattagttg atttttattt ttgacatata catgtgaatg aaagacccca      10080

cctgtaggtt tggcaagcta gcttaagt                                         10108


<210>    34
<211>    9901
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVe-F1-TK vector


<400>    34
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacgtgat       1800

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat       1860

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt       1920

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg       1980

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga       2040

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag       2100

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg       2160

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta       2220

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga       2280

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc       2340

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc       2400

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg       2460

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt       2520

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat       2580

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag       2640

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga       2700

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa       2760

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt       2820

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca       2880

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac       2940

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc       3000

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt       3060

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca       3120

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt       3180

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat       3240

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat       3300

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc       3360

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg       3420

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt       3480

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac       3540

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc       3600

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct       3660

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac       3720

tcaacaatat caccagctga agcctataga gtacgagcca tagcacgtga aggctgccga       3780

ccccgggggt ggacatcctc tagactgcca tggcgcggat ctcgacgttt aaacgggtga       3840

atcaacagga aagtcccatt ggagccaagt acactgagtc aatagggact ttccattggg       3900

ttttgcccag tacaaaaggt caataggggg tgagtcaatg ggtttttccc attattggca       3960

cgtacataag gtcaataggg gtgagtcatt gggtttttcc agccaattta attaaaacgc       4020

catgtacttt cccaccattg acgtcaatgg gctattgaaa ctaatgcaac gtgaccttta       4080

aacggtactt tcccatagct gattaatggg aaagtaccgt tctcgagcca atacacgtca       4140

atgggaagtg aaagggcagc caaaacgtaa caccgccccg gttttccctg gaaattccat       4200

attggcacgc attctattgg ctgagctgcg ttcacgtggg tataagaggc gcgaccagcg       4260

tcggtaccgt cgcagtcttc ggtctgacca ccgtagaacg cagagcggcc gctttagttt       4320

atggtgacat ggcttcgtac ccctgccatc aacacgcgtc tgcgttcgac caggctgcgc       4380

gttctcgcgg ccatagcaac cgacgtacgg cgttgcgccc tcgccggcag caagaagcca       4440

cggaagtccg cctggagcag aaaatgccca cgctactgcg ggtttatata gacggtcctc       4500

acgggatggg gaaaaccacc accacgcaac tgctggtggc cctgggttcg cgcgacgata       4560

tcgtctacgt acccgagccg atgacttact ggcaggtgct gggggcttcc gagacaatcg       4620

cgaacatcta caccacacaa caccgcctcg accagggtga gatatcggcc ggggacgcgg       4680

cggtggtaat gacaagcgcc cagataacaa tgggcatgcc ttatgccgtg accgacgccg       4740

ttctggctcc tcatatcggg ggggaggctg ggagctcaca tgccccgccc ccggccctca       4800

ccctcatctt cgaccgccat cccatcgccg ccctcctgtg ctacccggcc gcgcgatacc       4860

ttatgggcag catgaccccc caggccgtgc tggcgttcgt ggccctcatc ccgccgacct       4920

tgcccggcac aaacatcgtg ttgggggccc ttccggagga cagacacatc gaccgcctgg       4980

ccaaacgcca gcgccccggc gagcggcttg acctggctat gctggccgcg attcgccgcg       5040

tttacgggct gcttgccaat acggtgcggt atctgcaggg cggcgggtcg tggcgggagg       5100

attggggaca gctttcgggg acggccgtgc cgccccaggg tgccgagccc cagagcaacg       5160

cgggcccacg accccatatc ggggacacgt tatttaccct gtttcgggcc cccgagttgc       5220

tggcccccaa cggcgacctg tacaacgtgt ttgcctgggc cttggacgtc ttggccaaac       5280

gcctccgtcc catgcacgtc tttatcctgg attacgacca atcgcccgcc ggctgccggg       5340

acgccctgct gcaacttacc tccgggatgg tccagaccca cgtcaccacc cccggctcca       5400

taccgacgat ctgcgacctg gcgcgcacgt ttgcccggga gatgggggag gctaactgat       5460

cgagaaacgc gtcgacccat cgaacatcga tggtaccaga tccgataaaa taaaagattt       5520

tatttagtct ccagaaaaag gggggaatga aagaccccac ctgtaggttt ggcaagctag       5580

cttaagtaac gccattttgc aaggcatgga aaaatacata actgagaata gagaagttca       5640

gatcaaggtc aggaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa       5700

gcagttcctg ccccggctca gggccaagaa cagatggaac agctgaatat gggccaaaca       5760

ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat ggtccccaga       5820

tgcggtccag ccctcagcag tttctagaga accatcagat gtttccaggg tgccccaagg       5880

acctgaaatg accctgtgcc ttatttgaac taaccaatca gttcgcttct cgcttctgtt       5940

cgcgcgcttc tgctccccga gctcaataaa agagcccaca acccctcact cggggcgcca       6000

gtcctccgat tgactgagtc gcccgggtac ccgtgtatcc aataaaccct cttgcagttg       6060

catccgactt gtggtctcgc tgttccttgg gagggtctcc tctgagtgat tgactacccg       6120

tcagcggggg tctttcacac atgcagcatg tatcaaaatt aatttggttt tttttcttaa       6180

gtatttacat taaatggcca tagtacttaa agttacattg gcttccttga aataaacatg       6240

gagtattcag aatgtgtcat aaatatttct aattttaaga tagtatctcc attggctttc       6300

tactttttct tttatttttt tttgtcctct gtcttccatt tgttgttgtt gttgtttgtt       6360

tgtttgtttg ttggttggtt ggttaatttt tttttaaaga tcctacacta tagttcaagc       6420

tagactatta gctactctgt aacccagggt gaccttgaag tcatgggtag cctgctgttt       6480

tagccttccc acatctaaga ttacaggtat gagctatcat ttttggtata tgattgattg       6540

attgattgat gtgtgtgtgt gtgattgtgt ttgtgtgtgt gactgtgaaa atgtgtgtat       6600

gggtgtgtgt gaatgtgtgt atgtatgtgt gtgtgtgagt gtgtgtgtgt gtgtgtgcat       6660

gtgtgtgtgt gtgactgtgt ctatgtgtat gactgtgtgt gtgtgtgtgt gtgtgtgtgt       6720

gtgtgtgtgt gtgtgtgtgt tgtgaaaaaa tattctatgg tagtgagagc caacgctccg       6780

gctcaggtgt caggttggtt tttgagacag agtctttcac ttagcttgga attcactggc       6840

cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc       6900

agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc       6960

ccaacagttg cgcagcctga atggcgaatg gcgcctgatg cggtattttc tccttacgca       7020

tctgtgcggt atttcacacc gcatatggtg cactctcagt acaatctgct ctgatgccgc       7080

atagttaagc cagccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct       7140

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag       7200

gttttcaccg tcatcaccga aacgcgcgag acgaaagggc ctcgtgatac gcctattttt       7260

ataggttaat gtcatgataa taatggtttc ttagacgtca ggtggcactt ttcggggaaa       7320

tgtgcgcgga acccctattt gtttattttt ctaaatacat tcaaatatgt atccgctcat       7380

gagacaataa ccctgataaa tgcttcaata atattgaaaa aggaagagta tgagtattca       7440

acatttccgt gtcgccctta ttcccttttt tgcggcattt tgccttcctg tttttgctca       7500

cccagaaacg ctggtgaaag taaaagatgc tgaagatcag ttgggtgcac gagtgggtta       7560

catcgaactg gatctcaaca gcggtaagat ccttgagagt tttcgccccg aagaacgttt       7620

tccaatgatg agcactttta aagttctgct atgtggcgcg gtattatccc gtattgacgc       7680

cgggcaagag caactcggtc gccgcataca ctattctcag aatgacttgg ttgagtactc       7740

accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat gcagtgctgc       7800

cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg gaggaccgaa       7860

ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg atcgttggga       7920

accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc ctgtagcaat       7980

ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt cccggcaaca       8040

attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct cggcccttcc       8100

ggctggctgg tttattgctg ataaatctgg agccggtgag cgtgggtctc gcggtatcat       8160

tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca cgacggggag       8220

tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct cactgattaa       8280

gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt taaaacttca       8340

tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga ccaaaatccc       8400

ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca aaggatcttc       8460

ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       8520

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt       8580

cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt       8640

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc       8700

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa       8760

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac       8820

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg       8880

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga       8940

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact       9000

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa       9060

cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc       9120

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg       9180

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat       9240

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt       9300

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta       9360

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg       9420

ataacaattt cacacaggaa acagctatga ccatgattac gccaagcttt gctcctagga       9480

gtttcctaat acttcccaaa ctcaaatata taaagcattt gacttgttct atgccctagg       9540

gggcgggggg aagctaagcc agcttttttt aacatttaaa atgttaattc cattttaaat       9600

gcacagatgt ttttatttca taagggtttc aatgtgcatg aatgctgcaa tattcctgtt       9660

accaaagcta gtataaataa aaatagataa acgtggaaat tacttagagt ttctgtcatt       9720

aacgtttcct tcctcagttg acaacataaa tgcgctgctg agcaagccag tttgcatctg       9780

tcaggatcaa tttcccatta tgccagtcat attaattact agtcaattag ttgattttta       9840

tttttgacat atacatgtga atgaaagacc ccacctgtag gtttggcaag ctagcttaag       9900

t                                                                       9901


<210>    35
<211>    9768
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVe-F2-TK vector


<400>    35
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacgtgat       1800

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat       1860

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt       1920

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg       1980

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga       2040

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag       2100

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg       2160

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta       2220

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga       2280

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc       2340

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc       2400

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg       2460

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt       2520

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat       2580

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag       2640

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga       2700

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa       2760

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt       2820

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca       2880

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac       2940

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc       3000

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt       3060

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca       3120

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt       3180

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat       3240

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat       3300

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc       3360

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg       3420

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt       3480

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac       3540

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc       3600

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct       3660

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac       3720

tcaacaatat caccagctga agcctataga gtacgagcca tagcacgtga aggctgccga       3780

ccccgggggt ggacatcctc tagactgcca tggcgcggat ctcgacgttt aaacaaggtc       3840

aataggggtg agtcattggg tttttccagc caatttaatt aaaacgccat gtactttccc       3900

accattgacg tcaatgggct attgaaacta atgcaacgtg acctttaaac ggtactttcc       3960

catagctgat taatgggaaa gtaccgttct cgagccaata cacgtcaatg ggaagtgaaa       4020

gggcagccaa aacgtaacac cgccccggtt ttccctggaa attccatatt ggcacgcatt       4080

ctattggctg agctgcgttc acgtgggtat aagaggcgcg accagcgtcg gtaccgtcgc       4140

agtcttcggt ctgaccaccg tagaacgcag agcggccgct ttagtttatg gtgacatggc       4200

ttcgtacccc tgccatcaac acgcgtctgc gttcgaccag gctgcgcgtt ctcgcggcca       4260

tagcaaccga cgtacggcgt tgcgccctcg ccggcagcaa gaagccacgg aagtccgcct       4320

ggagcagaaa atgcccacgc tactgcgggt ttatatagac ggtcctcacg ggatggggaa       4380

aaccaccacc acgcaactgc tggtggccct gggttcgcgc gacgatatcg tctacgtacc       4440

cgagccgatg acttactggc aggtgctggg ggcttccgag acaatcgcga acatctacac       4500

cacacaacac cgcctcgacc agggtgagat atcggccggg gacgcggcgg tggtaatgac       4560

aagcgcccag ataacaatgg gcatgcctta tgccgtgacc gacgccgttc tggctcctca       4620

tatcgggggg gaggctggga gctcacatgc cccgcccccg gccctcaccc tcatcttcga       4680

ccgccatccc atcgccgccc tcctgtgcta cccggccgcg cgatacctta tgggcagcat       4740

gaccccccag gccgtgctgg cgttcgtggc cctcatcccg ccgaccttgc ccggcacaaa       4800

catcgtgttg ggggcccttc cggaggacag acacatcgac cgcctggcca aacgccagcg       4860

ccccggcgag cggcttgacc tggctatgct ggccgcgatt cgccgcgttt acgggctgct       4920

tgccaatacg gtgcggtatc tgcagggcgg cgggtcgtgg cgggaggatt ggggacagct       4980

ttcggggacg gccgtgccgc cccagggtgc cgagccccag agcaacgcgg gcccacgacc       5040

ccatatcggg gacacgttat ttaccctgtt tcgggccccc gagttgctgg cccccaacgg       5100

cgacctgtac aacgtgtttg cctgggcctt ggacgtcttg gccaaacgcc tccgtcccat       5160

gcacgtcttt atcctggatt acgaccaatc gcccgccggc tgccgggacg ccctgctgca       5220

acttacctcc gggatggtcc agacccacgt caccaccccc ggctccatac cgacgatctg       5280

cgacctggcg cgcacgtttg cccgggagat gggggaggct aactgatcga gaaacgcgtc       5340

gacccatcga acatcgatgg taccagatcc gataaaataa aagattttat ttagtctcca       5400

gaaaaagggg ggaatgaaag accccacctg taggtttggc aagctagctt aagtaacgcc       5460

attttgcaag gcatggaaaa atacataact gagaatagag aagttcagat caaggtcagg       5520

aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca gttcctgccc       5580

cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga tatctgtggt       5640

aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc ggtccagccc       5700

tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc tgaaatgacc       5760

ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc gcgcttctgc       5820

tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc ctccgattga       5880

ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat ccgacttgtg       5940

gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca gcgggggtct       6000

ttcacacatg cagcatgtat caaaattaat ttggtttttt ttcttaagta tttacattaa       6060

atggccatag tacttaaagt tacattggct tccttgaaat aaacatggag tattcagaat       6120

gtgtcataaa tatttctaat tttaagatag tatctccatt ggctttctac tttttctttt       6180

attttttttt gtcctctgtc ttccatttgt tgttgttgtt gtttgtttgt ttgtttgttg       6240

gttggttggt taattttttt ttaaagatcc tacactatag ttcaagctag actattagct       6300

actctgtaac ccagggtgac cttgaagtca tgggtagcct gctgttttag ccttcccaca       6360

tctaagatta caggtatgag ctatcatttt tggtatatga ttgattgatt gattgatgtg       6420

tgtgtgtgtg attgtgtttg tgtgtgtgac tgtgaaaatg tgtgtatggg tgtgtgtgaa       6480

tgtgtgtatg tatgtgtgtg tgtgagtgtg tgtgtgtgtg tgtgcatgtg tgtgtgtgtg       6540

actgtgtcta tgtgtatgac tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg       6600

tgtgtgttgt gaaaaaatat tctatggtag tgagagccaa cgctccggct caggtgtcag       6660

gttggttttt gagacagagt ctttcactta gcttggaatt cactggccgt cgttttacaa       6720

cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct       6780

ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc       6840

agcctgaatg gcgaatggcg cctgatgcgg tattttctcc ttacgcatct gtgcggtatt       6900

tcacaccgca tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag       6960

ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc       7020

gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca       7080

tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc       7140

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc       7200

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc       7260

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc       7320

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg       7380

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat       7440

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc       7500

acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa       7560

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa       7620

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt       7680

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct       7740

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat       7800

gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg       7860

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg       7920

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt       7980

attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg       8040

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg       8100

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg       8160

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa       8220

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt       8280

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt       8340

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt       8400

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag       8460

ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa gaactctgta       8520

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat       8580

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg       8640

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg       8700

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac       8760

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga       8820

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt       8880

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta       8940

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat       9000

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg       9060

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcccaatacg caaaccgcct       9120

ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc cgactggaaa       9180

gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc accccaggct       9240

ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac       9300

acaggaaaca gctatgacca tgattacgcc aagctttgct cctaggagtt tcctaatact       9360

tcccaaactc aaatatataa agcatttgac ttgttctatg ccctaggggg cggggggaag       9420

ctaagccagc tttttttaac atttaaaatg ttaattccat tttaaatgca cagatgtttt       9480

tatttcataa gggtttcaat gtgcatgaat gctgcaatat tcctgttacc aaagctagta       9540

taaataaaaa tagataaacg tggaaattac ttagagtttc tgtcattaac gtttccttcc       9600

tcagttgaca acataaatgc gctgctgagc aagccagttt gcatctgtca ggatcaattt       9660

cccattatgc cagtcatatt aattactagt caattagttg atttttattt ttgacatata       9720

catgtgaatg aaagacccca cctgtaggtt tggcaagcta gcttaagt                    9768


<210>    36
<211>    9668
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVe-F3-TK vector


<400>    36
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacgtgat       1800

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat       1860

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt       1920

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg       1980

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga       2040

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag       2100

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg       2160

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta       2220

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga       2280

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc       2340

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc       2400

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg       2460

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt       2520

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat       2580

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag       2640

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga       2700

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa       2760

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt       2820

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca       2880

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac       2940

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc       3000

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt       3060

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca       3120

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt       3180

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat       3240

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat       3300

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc       3360

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg       3420

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt       3480

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac       3540

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc       3600

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct       3660

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac       3720

tcaacaatat caccagctga agcctataga gtacgagcca tagcacgtga aggctgccga       3780

ccccgggggt ggacatcctc tagactgcca tggcgcggat ctcgacgttt aaacaacgtg       3840

acctttaaac ggtactttcc catagctgat taatgggaaa gtaccgttct cgagccaata       3900

cacgtcaatg ggaagtgaaa gggcagccaa aacgtaacac cgccccggtt ttccctggaa       3960

attccatatt ggcacgcatt ctattggctg agctgcgttc acgtgggtat aagaggcgcg       4020

accagcgtcg gtaccgtcgc agtcttcggt ctgaccaccg tagaacgcag agcggccgct       4080

ttagtttatg gtgacatggc ttcgtacccc tgccatcaac acgcgtctgc gttcgaccag       4140

gctgcgcgtt ctcgcggcca tagcaaccga cgtacggcgt tgcgccctcg ccggcagcaa       4200

gaagccacgg aagtccgcct ggagcagaaa atgcccacgc tactgcgggt ttatatagac       4260

ggtcctcacg ggatggggaa aaccaccacc acgcaactgc tggtggccct gggttcgcgc       4320

gacgatatcg tctacgtacc cgagccgatg acttactggc aggtgctggg ggcttccgag       4380

acaatcgcga acatctacac cacacaacac cgcctcgacc agggtgagat atcggccggg       4440

gacgcggcgg tggtaatgac aagcgcccag ataacaatgg gcatgcctta tgccgtgacc       4500

gacgccgttc tggctcctca tatcgggggg gaggctggga gctcacatgc cccgcccccg       4560

gccctcaccc tcatcttcga ccgccatccc atcgccgccc tcctgtgcta cccggccgcg       4620

cgatacctta tgggcagcat gaccccccag gccgtgctgg cgttcgtggc cctcatcccg       4680

ccgaccttgc ccggcacaaa catcgtgttg ggggcccttc cggaggacag acacatcgac       4740

cgcctggcca aacgccagcg ccccggcgag cggcttgacc tggctatgct ggccgcgatt       4800

cgccgcgttt acgggctgct tgccaatacg gtgcggtatc tgcagggcgg cgggtcgtgg       4860

cgggaggatt ggggacagct ttcggggacg gccgtgccgc cccagggtgc cgagccccag       4920

agcaacgcgg gcccacgacc ccatatcggg gacacgttat ttaccctgtt tcgggccccc       4980

gagttgctgg cccccaacgg cgacctgtac aacgtgtttg cctgggcctt ggacgtcttg       5040

gccaaacgcc tccgtcccat gcacgtcttt atcctggatt acgaccaatc gcccgccggc       5100

tgccgggacg ccctgctgca acttacctcc gggatggtcc agacccacgt caccaccccc       5160

ggctccatac cgacgatctg cgacctggcg cgcacgtttg cccgggagat gggggaggct       5220

aactgatcga gaaacgcgtc gacccatcga acatcgatgg taccagatcc gataaaataa       5280

aagattttat ttagtctcca gaaaaagggg ggaatgaaag accccacctg taggtttggc       5340

aagctagctt aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagag       5400

aagttcagat caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct       5460

gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg       5520

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt       5580

ccccagatgc ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc       5640

cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc       5700

ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc cctcactcgg       5760

ggcgccagtc ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt       5820

gcagttgcat ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga       5880

ctacccgtca gcgggggtct ttcacacatg cagcatgtat caaaattaat ttggtttttt       5940

ttcttaagta tttacattaa atggccatag tacttaaagt tacattggct tccttgaaat       6000

aaacatggag tattcagaat gtgtcataaa tatttctaat tttaagatag tatctccatt       6060

ggctttctac tttttctttt attttttttt gtcctctgtc ttccatttgt tgttgttgtt       6120

gtttgtttgt ttgtttgttg gttggttggt taattttttt ttaaagatcc tacactatag       6180

ttcaagctag actattagct actctgtaac ccagggtgac cttgaagtca tgggtagcct       6240

gctgttttag ccttcccaca tctaagatta caggtatgag ctatcatttt tggtatatga       6300

ttgattgatt gattgatgtg tgtgtgtgtg attgtgtttg tgtgtgtgac tgtgaaaatg       6360

tgtgtatggg tgtgtgtgaa tgtgtgtatg tatgtgtgtg tgtgagtgtg tgtgtgtgtg       6420

tgtgcatgtg tgtgtgtgtg actgtgtcta tgtgtatgac tgtgtgtgtg tgtgtgtgtg       6480

tgtgtgtgtg tgtgtgtgtg tgtgtgttgt gaaaaaatat tctatggtag tgagagccaa       6540

cgctccggct caggtgtcag gttggttttt gagacagagt ctttcactta gcttggaatt       6600

cactggccgt cgttttacaa cgtcgtgact gggaaaaccc tggcgttacc caacttaatc       6660

gccttgcagc acatccccct ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc       6720

gcccttccca acagttgcgc agcctgaatg gcgaatggcg cctgatgcgg tattttctcc       6780

ttacgcatct gtgcggtatt tcacaccgca tatggtgcac tctcagtaca atctgctctg       6840

atgccgcata gttaagccag ccccgacacc cgccaacacc cgctgacgcg ccctgacggg       6900

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt       6960

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgagacg aaagggcctc gtgatacgcc       7020

tatttttata ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc       7080

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc       7140

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga       7200

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt       7260

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag       7320

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag       7380

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta       7440

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg       7500

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca       7560

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag       7620

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc       7680

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg       7740

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc       7800

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg       7860

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg       7920

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga       7980

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac       8040

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa       8100

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca       8160

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag       8220

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac       8280

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa       8340

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc       8400

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag       8460

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac       8520

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc       8580

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc       8640

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca       8700

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc       8760

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg       8820

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct       8880

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata       8940

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc       9000

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg       9060

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca       9120

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg       9180

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc aagctttgct       9240

cctaggagtt tcctaatact tcccaaactc aaatatataa agcatttgac ttgttctatg       9300

ccctaggggg cggggggaag ctaagccagc tttttttaac atttaaaatg ttaattccat       9360

tttaaatgca cagatgtttt tatttcataa gggtttcaat gtgcatgaat gctgcaatat       9420

tcctgttacc aaagctagta taaataaaaa tagataaacg tggaaattac ttagagtttc       9480

tgtcattaac gtttccttcc tcagttgaca acataaatgc gctgctgagc aagccagttt       9540

gcatctgtca ggatcaattt cccattatgc cagtcatatt aattactagt caattagttg       9600

atttttattt ttgacatata catgtgaatg aaagacccca cctgtaggtt tggcaagcta       9660

gcttaagt                                                                9668


<210>    37
<211>    9592
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVe-F4-TK vector


<400>    37
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacgtgat       1800

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat       1860

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt       1920

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg       1980

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga       2040

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag       2100

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg       2160

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta       2220

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga       2280

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc       2340

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc       2400

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg       2460

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt       2520

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat       2580

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag       2640

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga       2700

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa       2760

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt       2820

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca       2880

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac       2940

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc       3000

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt       3060

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca       3120

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt       3180

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat       3240

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat       3300

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc       3360

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg       3420

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt       3480

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac       3540

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc       3600

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct       3660

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac       3720

tcaacaatat caccagctga agcctataga gtacgagcca tagcacgtga aggctgccga       3780

ccccgggggt ggacatcctc tagactgcca tggcgcggat ctcgacgttt aaacggaagt       3840

gaaagggcag ccaaaacgta acaccgcccc ggttttccct ggaaattcca tattggcacg       3900

cattctattg gctgagctgc gttcacgtgg gtataagagg cgcgaccagc gtcggtaccg       3960

tcgcagtctt cggtctgacc accgtagaac gcagagcggc cgctttagtt tatggtgaca       4020

tggcttcgta cccctgccat caacacgcgt ctgcgttcga ccaggctgcg cgttctcgcg       4080

gccatagcaa ccgacgtacg gcgttgcgcc ctcgccggca gcaagaagcc acggaagtcc       4140

gcctggagca gaaaatgccc acgctactgc gggtttatat agacggtcct cacgggatgg       4200

ggaaaaccac caccacgcaa ctgctggtgg ccctgggttc gcgcgacgat atcgtctacg       4260

tacccgagcc gatgacttac tggcaggtgc tgggggcttc cgagacaatc gcgaacatct       4320

acaccacaca acaccgcctc gaccagggtg agatatcggc cggggacgcg gcggtggtaa       4380

tgacaagcgc ccagataaca atgggcatgc cttatgccgt gaccgacgcc gttctggctc       4440

ctcatatcgg gggggaggct gggagctcac atgccccgcc cccggccctc accctcatct       4500

tcgaccgcca tcccatcgcc gccctcctgt gctacccggc cgcgcgatac cttatgggca       4560

gcatgacccc ccaggccgtg ctggcgttcg tggccctcat cccgccgacc ttgcccggca       4620

caaacatcgt gttgggggcc cttccggagg acagacacat cgaccgcctg gccaaacgcc       4680

agcgccccgg cgagcggctt gacctggcta tgctggccgc gattcgccgc gtttacgggc       4740

tgcttgccaa tacggtgcgg tatctgcagg gcggcgggtc gtggcgggag gattggggac       4800

agctttcggg gacggccgtg ccgccccagg gtgccgagcc ccagagcaac gcgggcccac       4860

gaccccatat cggggacacg ttatttaccc tgtttcgggc ccccgagttg ctggccccca       4920

acggcgacct gtacaacgtg tttgcctggg ccttggacgt cttggccaaa cgcctccgtc       4980

ccatgcacgt ctttatcctg gattacgacc aatcgcccgc cggctgccgg gacgccctgc       5040

tgcaacttac ctccgggatg gtccagaccc acgtcaccac ccccggctcc ataccgacga       5100

tctgcgacct ggcgcgcacg tttgcccggg agatggggga ggctaactga tcgagaaacg       5160

cgtcgaccca tcgaacatcg atggtaccag atccgataaa ataaaagatt ttatttagtc       5220

tccagaaaaa ggggggaatg aaagacccca cctgtaggtt tggcaagcta gcttaagtaa       5280

cgccattttg caaggcatgg aaaaatacat aactgagaat agagaagttc agatcaaggt       5340

caggaacaga tggaacagct gaatatgggc caaacaggat atctgtggta agcagttcct       5400

gccccggctc agggccaaga acagatggaa cagctgaata tgggccaaac aggatatctg       5460

tggtaagcag ttcctgcccc ggctcagggc caagaacaga tggtccccag atgcggtcca       5520

gccctcagca gtttctagag aaccatcaga tgtttccagg gtgccccaag gacctgaaat       5580

gaccctgtgc cttatttgaa ctaaccaatc agttcgcttc tcgcttctgt tcgcgcgctt       5640

ctgctccccg agctcaataa aagagcccac aacccctcac tcggggcgcc agtcctccga       5700

ttgactgagt cgcccgggta cccgtgtatc caataaaccc tcttgcagtt gcatccgact       5760

tgtggtctcg ctgttccttg ggagggtctc ctctgagtga ttgactaccc gtcagcgggg       5820

gtctttcaca catgcagcat gtatcaaaat taatttggtt ttttttctta agtatttaca       5880

ttaaatggcc atagtactta aagttacatt ggcttccttg aaataaacat ggagtattca       5940

gaatgtgtca taaatatttc taattttaag atagtatctc cattggcttt ctactttttc       6000

ttttattttt ttttgtcctc tgtcttccat ttgttgttgt tgttgtttgt ttgtttgttt       6060

gttggttggt tggttaattt ttttttaaag atcctacact atagttcaag ctagactatt       6120

agctactctg taacccaggg tgaccttgaa gtcatgggta gcctgctgtt ttagccttcc       6180

cacatctaag attacaggta tgagctatca tttttggtat atgattgatt gattgattga       6240

tgtgtgtgtg tgtgattgtg tttgtgtgtg tgactgtgaa aatgtgtgta tgggtgtgtg       6300

tgaatgtgtg tatgtatgtg tgtgtgtgag tgtgtgtgtg tgtgtgtgca tgtgtgtgtg       6360

tgtgactgtg tctatgtgta tgactgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg       6420

tgtgtgtgtg ttgtgaaaaa atattctatg gtagtgagag ccaacgctcc ggctcaggtg       6480

tcaggttggt ttttgagaca gagtctttca cttagcttgg aattcactgg ccgtcgtttt       6540

acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc       6600

ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt       6660

gcgcagcctg aatggcgaat ggcgcctgat gcggtatttt ctccttacgc atctgtgcgg       6720

tatttcacac cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag       6780

ccagccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc tgctcccggc       6840

atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc       6900

gtcatcaccg aaacgcgcga gacgaaaggg cctcgtgata cgcctatttt tataggttaa       6960

tgtcatgata ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg       7020

aacccctatt tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata       7080

accctgataa atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg       7140

tgtcgccctt attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac       7200

gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact       7260

ggatctcaac agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat       7320

gagcactttt aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga       7380

gcaactcggt cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac       7440

agaaaagcat cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat       7500

gagtgataac actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac       7560

cgcttttttg cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct       7620

gaatgaagcc ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac       7680

gttgcgcaaa ctattaactg gcgaactact tactctagct tcccggcaac aattaataga       7740

ctggatggag gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg       7800

gtttattgct gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact       7860

ggggccagat ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac       7920

tatggatgaa cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta       7980

actgtcagac caagtttact catatatact ttagattgat ttaaaacttc atttttaatt       8040

taaaaggatc taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga       8100

gttttcgttc cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc       8160

tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt       8220

ttgtttgccg gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc       8280

gcagatacca aatactgttc ttctagtgta gccgtagtta ggccaccact tcaagaactc       8340

tgtagcaccg cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg       8400

cgataagtcg tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg       8460

gtcgggctga acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga       8520

actgagatac ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc       8580

ggacaggtat ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg       8640

gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg       8700

atttttgtga tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt       8760

tttacggttc ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc       8820

tgattctgtg gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg       8880

aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa gagcgcccaa tacgcaaacc       8940

gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg       9000

gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca       9060

ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt       9120

tcacacagga aacagctatg accatgatta cgccaagctt tgctcctagg agtttcctaa       9180

tacttcccaa actcaaatat ataaagcatt tgacttgttc tatgccctag ggggcggggg       9240

gaagctaagc cagctttttt taacatttaa aatgttaatt ccattttaaa tgcacagatg       9300

tttttatttc ataagggttt caatgtgcat gaatgctgca atattcctgt taccaaagct       9360

agtataaata aaaatagata aacgtggaaa ttacttagag tttctgtcat taacgtttcc       9420

ttcctcagtt gacaacataa atgcgctgct gagcaagcca gtttgcatct gtcaggatca       9480

atttcccatt atgccagtca tattaattac tagtcaatta gttgattttt atttttgaca       9540

tatacatgtg aatgaaagac cccacctgta ggtttggcaa gctagcttaa gt               9592


<210>    38
<211>    29
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV(F4)-EcoRI-F


<400>    38
cggaattcgg aagtgaaagg gcagccaaa                                           29


<210>    39
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV-NotI-MluI-EcoRI-R


<400>    39
cggaattcac gcgtgcgcgg ccgctctgcg ttctacggtg gtcagacc                      48


<210>    40
<211>    30
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hopt-yCD-NotI-F


<400>    40
cggcggccgc atggttactg ggggaatggc                                          30


<210>    41
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hopt-yCD-MluI-R


<400>    41
acgcgtttat tccccgatgt cttcgaa                                             27


<210>    42
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    AmEnv961F


<400>    42
acaagaccca agaatgttgg ct                                                  22


<210>    43
<211>    1671
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hCD19 variant 2


<400>    43
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc         60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag        120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc        180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc        240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg        300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag        360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc        420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc        480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg        540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt        600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag        660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg        720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat        780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta        840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg        900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg        960

aggaaaagaa agcgaatgac tgaccccacc aggagattct tcaaagtgac gcctccccca       1020

ggaagcgggc cccagaacca gtacgggaac gtgctgtctc tccccacacc cacctcaggc       1080

ctcggacgcg cccagcgttg ggccgcaggc ctggggggca ctgccccgtc ttatggaaac       1140

ccgagcagcg acgtccaggc ggatggagcc ttggggtccc ggagcccgcc gggagtgggc       1200

ccagaagaag aggaagggga gggctatgag gaacctgaca gtgaggagga ctccgagttc       1260

tatgagaacg actccaacct tgggcaggac cagctctccc aggatggcag cggctacgag       1320

aaccctgagg atgagcccct gggtcctgag gatgaagact ccttctccaa cgctgagtct       1380

tatgagaacg aggatgaaga gctgacccag ccggtcgcca ggacaatgga cttcctgagc       1440

cctcatgggt cagcctggga ccccagccgg gaagcaacct ccctggggtc ccagtcctat       1500

gaggatatga gaggaatcct gtatgcagcc ccccagctcc gctccattcg gggccagcct       1560

ggacccaatc atgaggaaga tgcagactct tatgagaaca tggataatcc cgatgggcca       1620

gacccagcct ggggaggagg gggccgcatg ggcacctgga gcaccaggtg a                1671


<210>    44
<211>    11157
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-F4-hCD19 vector


<400>    44
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcggaagtg       8040

aaagggcagc caaaacgtaa caccgccccg gttttccctg gaaattccat attggcacgc       8100

attctattgg ctgagctgcg ttcacgtggg tataagaggc gcgaccagcg tcggtaccgt       8160

cgcagtcttc ggtctgacca ccgtagaacg cagagcggcc gcatgccacc tcctcgcctc       8220

ctcttcttcc tcctcttcct cacccccatg gaagtcaggc ccgaggaacc tctagtggtg       8280

aaggtggaag agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc       8340

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg       8400

gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac       8460

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc       8520

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt       8580

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc       8640

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc       8700

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccag       8760

gacctcacca tggcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct       8820

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg       8880

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatgga gacgggtctg       8940

ttgttgcccc gggccacagc tcaagacgct ggaaagtatt attgtcaccg tggcaacctg       9000

accatgtcat tccacctgga gatcactgct cggccagtac tatggcactg gctgctgagg       9060

actggtggct ggaaggtctc agctgtgact ttggcttatc tgatcttctg cctgtgttcc       9120

cttgtgggca ttcttcatct tcaaagagcc ctggtcctga ggaggaaaag aaagcgaatg       9180

actgacccca ccaggagatt cttcaaagtg acgcctcccc caggaagcgg gccccagaac       9240

cagtacggga acgtgctgtc tctccccaca cccacctcag gcctcggacg cgcccagcgt       9300

tgggccgcag gcctgggggg cactgccccg tcttatggaa acccgagcag cgacgtccag       9360

gcggatggag ccttggggtc ccggagcccg ccgggagtgg gcccagaaga agaggaaggg       9420

gagggctatg aggaacctga cagtgaggag gactccgagt tctatgagaa cgactccaac       9480

cttgggcagg accagctctc ccaggatggc agcggctacg agaaccctga ggatgagccc       9540

ctgggtcctg aggatgaaga ctccttctcc aacgctgagt cttatgagaa cgaggatgaa       9600

gagctgaccc agccggtcgc caggacaatg gacttcctga gccctcatgg gtcagcctgg       9660

gaccccagcc gggaagcaac ctccctgggg tcccagtcct atgaggatat gagaggaatc       9720

ctgtatgcag ccccccagct ccgctccatt cggggccagc ctggacccaa tcatgaggaa       9780

gatgcagact cttatgagaa catggataat cccgatgggc cagacccagc ctggggagga       9840

gggggccgca tgggcacctg gagcaccagg tgagtttaaa cacgcgtgaa ttcataaaat       9900

aaaagatttt atttagtctc cagaaaaagg ggggaatgaa agaccccacc tgtaggtttg       9960

gcaagctagc ttaagtaacg ccattttgca aggcatggaa aaatacataa ctgagaatag      10020

agaagttcag atcaaggtca ggaacagatg gaacagctga atatgggcca aacaggatat      10080

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggaaca gctgaatatg      10140

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg      10200

gtccccagat gcggtccagc cctcagcagt ttctagagaa ccatcagatg tttccagggt      10260

gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag ttcgcttctc      10320

gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa cccctcactc      10380

ggggcgccag tcctccgatt gactgagtcg cccgggtacc cgtgtatcca ataaaccctc      10440

ttgcagttgc atccgacttg tggtctcgct gttccttggg agggtctcct ctgagtgatt      10500

gactacccgt cagcgggggt ctttcattgt tacttaaagt tacattggct tccttgaaat      10560

aaacatggag tattcagaat gtgtcataaa tatttctaat tttaagatag tatctccatt      10620

ggctttctac tttttctttt attttttttt gtcctctgtc ttccatttgt tgttgttgtt      10680

gtttgtttgt ttgtttgttg gttggttggt taattttttt ttaaagatcc tacactatag      10740

ttcaagctag actattagct actctgtaac ccagggtgac cttgaagtca tgggtagcct      10800

gctgttttag ccttcccaca tctaagatta caggtatgag ctatcatttt tggtatattg      10860

attgattgat tgattgatgt gtgtgtgtgt gattgtgttt gtgtgtgtga ctgtgaaaat      10920

gtgtgtatgg gtgtgtgtga atgtgtgtat gtatgtgtgt gtgtgagtgt gtgtgtgtgt      10980

gtgtgcatgt gtgtgtgtgt gactgtgtct atgtgtatga ctgtgtgtgt gtgtgtgtgt      11040

gtgtgtgtgt gtgtgtgtgt gtgtgtgttg tgaaaaaata ttctatggta gtgagagcca      11100

acgctccggc tcaggtgtca ggttggtttt tgagacagag tctttcactt agcttgg         11157


<210>    45
<211>    10105
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVe-F4-hCD19 vector


<400>    45
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacgtgat       1800

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat       1860

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt       1920

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg       1980

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga       2040

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag       2100

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg       2160

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta       2220

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga       2280

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc       2340

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc       2400

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg       2460

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt       2520

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat       2580

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag       2640

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga       2700

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa       2760

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt       2820

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca       2880

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac       2940

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc       3000

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt       3060

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca       3120

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt       3180

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat       3240

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat       3300

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc       3360

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg       3420

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt       3480

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac       3540

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc       3600

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct       3660

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac       3720

tcaacaatat caccagctga agcctataga gtacgagcca tagcacgtga aggctgccga       3780

ccccgggggt ggacatcctc tagactgcca tggcgcggat ctcgacgttt aaacggaagt       3840

gaaagggcag ccaaaacgta acaccgcccc ggttttccct ggaaattcca tattggcacg       3900

cattctattg gctgagctgc gttcacgtgg gtataagagg cgcgaccagc gtcggtaccg       3960

tcgcagtctt cggtctgacc accgtagaac gcagagcggc cgcatgccac ctcctcgcct       4020

cctcttcttc ctcctcttcc tcacccccat ggaagtcagg cccgaggaac ctctagtggt       4080

gaaggtggaa gagggagata acgctgtgct gcagtgcctc aaggggacct cagatggccc       4140

cactcagcag ctgacctggt ctcgggagtc cccgcttaaa cccttcttaa aactcagcct       4200

ggggctgcca ggcctgggaa tccacatgag gcccctggcc atctggcttt tcatcttcaa       4260

cgtctctcaa cagatggggg gcttctacct gtgccagccg gggcccccct ctgagaaggc       4320

ctggcagcct ggctggacag tcaatgtgga gggcagcggg gagctgttcc ggtggaatgt       4380

ttcggaccta ggtggcctgg gctgtggcct gaagaacagg tcctcagagg gccccagctc       4440

cccttccggg aagctcatga gccccaagct gtatgtgtgg gccaaagacc gccctgagat       4500

ctgggaggga gagcctccgt gtctcccacc gagggacagc ctgaaccaga gcctcagcca       4560

ggacctcacc atggcccctg gctccacact ctggctgtcc tgtggggtac cccctgactc       4620

tgtgtccagg ggccccctct cctggaccca tgtgcacccc aaggggccta agtcattgct       4680

gagcctagag ctgaaggacg atcgcccggc cagagatatg tgggtaatgg agacgggtct       4740

gttgttgccc cgggccacag ctcaagacgc tggaaagtat tattgtcacc gtggcaacct       4800

gaccatgtca ttccacctgg agatcactgc tcggccagta ctatggcact ggctgctgag       4860

gactggtggc tggaaggtct cagctgtgac tttggcttat ctgatcttct gcctgtgttc       4920

ccttgtgggc attcttcatc ttcaaagagc cctggtcctg aggaggaaaa gaaagcgaat       4980

gactgacccc accaggagat tcttcaaagt gacgcctccc ccaggaagcg ggccccagaa       5040

ccagtacggg aacgtgctgt ctctccccac acccacctca ggcctcggac gcgcccagcg       5100

ttgggccgca ggcctggggg gcactgcccc gtcttatgga aacccgagca gcgacgtcca       5160

ggcggatgga gccttggggt cccggagccc gccgggagtg ggcccagaag aagaggaagg       5220

ggagggctat gaggaacctg acagtgagga ggactccgag ttctatgaga acgactccaa       5280

ccttgggcag gaccagctct cccaggatgg cagcggctac gagaaccctg aggatgagcc       5340

cctgggtcct gaggatgaag actccttctc caacgctgag tcttatgaga acgaggatga       5400

agagctgacc cagccggtcg ccaggacaat ggacttcctg agccctcatg ggtcagcctg       5460

ggaccccagc cgggaagcaa cctccctggg gtcccagtcc tatgaggata tgagaggaat       5520

cctgtatgca gccccccagc tccgctccat tcggggccag cctggaccca atcatgagga       5580

agatgcagac tcttatgaga acatggataa tcccgatggg ccagacccag cctggggagg       5640

agggggccgc atgggcacct ggagcaccag gtgagtcgac ccatcgaaca tcgatggtac       5700

cagatccgat aaaataaaag attttattta gtctccagaa aaagggggga atgaaagacc       5760

ccacctgtag gtttggcaag ctagcttaag taacgccatt ttgcaaggca tggaaaaata       5820

cataactgag aatagagaag ttcagatcaa ggtcaggaac agatggaaca gctgaatatg       5880

ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca agaacagatg       5940

gaacagctga atatgggcca aacaggatat ctgtggtaag cagttcctgc cccggctcag       6000

ggccaagaac agatggtccc cagatgcggt ccagccctca gcagtttcta gagaaccatc       6060

agatgtttcc agggtgcccc aaggacctga aatgaccctg tgccttattt gaactaacca       6120

atcagttcgc ttctcgcttc tgttcgcgcg cttctgctcc ccgagctcaa taaaagagcc       6180

cacaacccct cactcggggc gccagtcctc cgattgactg agtcgcccgg gtacccgtgt       6240

atccaataaa ccctcttgca gttgcatccg acttgtggtc tcgctgttcc ttgggagggt       6300

ctcctctgag tgattgacta cccgtcagcg ggggtctttc acacatgcag catgtatcaa       6360

aattaatttg gttttttttc ttaagtattt acattaaatg gccatagtac ttaaagttac       6420

attggcttcc ttgaaataaa catggagtat tcagaatgtg tcataaatat ttctaatttt       6480

aagatagtat ctccattggc tttctacttt ttcttttatt tttttttgtc ctctgtcttc       6540

catttgttgt tgttgttgtt tgtttgtttg tttgttggtt ggttggttaa ttttttttta       6600

aagatcctac actatagttc aagctagact attagctact ctgtaaccca gggtgacctt       6660

gaagtcatgg gtagcctgct gttttagcct tcccacatct aagattacag gtatgagcta       6720

tcatttttgg tatatgattg attgattgat tgatgtgtgt gtgtgtgatt gtgtttgtgt       6780

gtgtgactgt gaaaatgtgt gtatgggtgt gtgtgaatgt gtgtatgtat gtgtgtgtgt       6840

gagtgtgtgt gtgtgtgtgt gcatgtgtgt gtgtgtgact gtgtctatgt gtatgactgt       6900

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgtgaa aaaatattct       6960

atggtagtga gagccaacgc tccggctcag gtgtcaggtt ggtttttgag acagagtctt       7020

tcacttagct tggaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg       7080

cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga       7140

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatggcgcct       7200

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct       7260

cagtacaatc tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc       7320

tgacgcgccc tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt       7380

ctccgggagc tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa       7440

gggcctcgtg atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac       7500

gtcaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat       7560

acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg       7620

aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc       7680

attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga       7740

tcagttgggt gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga       7800

gagttttcgc cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg       7860

cgcggtatta tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc       7920

tcagaatgac ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac       7980

agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact       8040

tctgacaacg atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca       8100

tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg       8160

tgacaccacg atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact       8220

acttactcta gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg       8280

accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg       8340

tgagcgtggg tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat       8400

cgtagttatc tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc       8460

tgagataggt gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat       8520

actttagatt gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt       8580

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc       8640

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt       8700

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac       8760

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt       8820

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct       8880

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga       8940

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac       9000

acagcccagc ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg       9060

agaaagcgcc acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt       9120

cggaacagga gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc       9180

tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg       9240

gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc       9300

ttttgctcac atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc       9360

ctttgagtga gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag       9420

cgaggaagcg gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca       9480

ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat       9540

taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg       9600

tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga       9660

ttacgccaag ctttgctcct aggagtttcc taatacttcc caaactcaaa tatataaagc       9720

atttgacttg ttctatgccc tagggggcgg ggggaagcta agccagcttt ttttaacatt       9780

taaaatgtta attccatttt aaatgcacag atgtttttat ttcataaggg tttcaatgtg       9840

catgaatgct gcaatattcc tgttaccaaa gctagtataa ataaaaatag ataaacgtgg       9900

aaattactta gagtttctgt cattaacgtt tccttcctca gttgacaaca taaatgcgct       9960

gctgagcaag ccagtttgca tctgtcagga tcaatttccc attatgccag tcatattaat      10020

tactagtcaa ttagttgatt tttatttttg acatatacat gtgaatgaaa gaccccacct      10080

gtaggtttgg caagctagct taagt                                            10105


<210>    46
<211>    9955
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-F4-hopt-yCD


<400>    46
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcggaagtg       8040

aaagggcagc caaaacgtaa caccgccccg gttttccctg gaaattccat attggcacgc       8100

attctattgg ctgagctgcg ttcacgtggg tataagaggc gcgaccagcg tcggtaccgt       8160

cgcagtcttc ggtctgacca ccgtagaacg cagagcggcc gcatggttac tgggggaatg       8220

gcatctaagt gggatcagaa aggtatggac atcgcttatg aagaggctgc tctcggctac       8280

aaagagggtg gagtgcctat cggagggtgc ctgatcaaca acaaggacgg cagtgtgctg       8340

gggaggggcc acaatatgag gttccaaaaa ggctccgcca ctctccacgg ggaaattagt       8400

accctcgaga attgcggacg attggaaggg aaggtgtaca aggatacaac actgtacacc       8460

accctgtcac cctgtgatat gtgcacaggc gccattatca tgtacggaat ccctagatgt       8520

gtcgtggggg agaatgtaaa cttcaaaagt aagggggaga aatatctcca gacccggggg       8580

cacgaagtcg tcgttgtgga cgatgaacgg tgtaagaaga tcatgaagca gtttatcgat       8640

gagaggcccc aggactggtt cgaagacatc ggggaataaa cgcgtgaatt cataaaataa       8700

aagattttat ttagtctcca gaaaaagggg ggaatgaaag accccacctg taggtttggc       8760

aagctagctt aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagag       8820

aagttcagat caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct       8880

gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg       8940

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt       9000

ccccagatgc ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc       9060

cccaaggacc tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc       9120

ttctgttcgc gcgcttctgc tccccgagct caataaaaga gcccacaacc cctcactcgg       9180

ggcgccagtc ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt       9240

gcagttgcat ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga       9300

ctacccgtca gcgggggtct ttcattgtta cttaaagtta cattggcttc cttgaaataa       9360

acatggagta ttcagaatgt gtcataaata tttctaattt taagatagta tctccattgg       9420

ctttctactt tttcttttat ttttttttgt cctctgtctt ccatttgttg ttgttgttgt       9480

ttgtttgttt gtttgttggt tggttggtta attttttttt aaagatccta cactatagtt       9540

caagctagac tattagctac tctgtaaccc agggtgacct tgaagtcatg ggtagcctgc       9600

tgttttagcc ttcccacatc taagattaca ggtatgagct atcatttttg gtatattgat       9660

tgattgattg attgatgtgt gtgtgtgtga ttgtgtttgt gtgtgtgact gtgaaaatgt       9720

gtgtatgggt gtgtgtgaat gtgtgtatgt atgtgtgtgt gtgagtgtgt gtgtgtgtgt       9780

gtgcatgtgt gtgtgtgtga ctgtgtctat gtgtatgact gtgtgtgtgt gtgtgtgtgt       9840

gtgtgtgtgt gtgtgtgtgt gtgtgttgtg aaaaaatatt ctatggtagt gagagccaac       9900

gctccggctc aggtgtcagg ttggtttttg agacagagtc tttcacttag cttgg            9955


<210>    47
<211>    28
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV-F-EcoRI


<400>    47
cggaattcaa caggaaagtc ccattgga                                            28


<210>    48
<211>    37
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    MCMV-R-PmeI-EcoRI


<400>    48
cggaattcgt ttaaacctgc gttctacggt ggtcaga                                  37


<210>    49
<211>    32
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TK-F-PmeI


<400>    49
cggtttaaac atggcttcgt acccctgcca tc                                       32


<210>    50
<211>    32
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    TK-R-PmeI


<400>    50
cggtttaaac tcagttagcc tcccccatct cc                                       32


<210>    51
<211>    34
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hCD19t-NotI-F


<400>    51
cggcggccgc atgccacctc ctcgcctcct cttc                                     34


<210>    52
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hCD19t-MluI-R


<400>    52
caacgcgttc atcttttcct cctcaggacc agg                                      33


<210>    53
<211>    972
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hCD19t polynucleotide sequence


<400>    53
atgccacctc ctcgcctcct cttcttcctc ctcttcctca cccccatgga agtcaggccc         60

gaggaacctc tagtggtgaa ggtggaagag ggagataacg ctgtgctgca gtgcctcaag        120

gggacctcag atggccccac tcagcagctg acctggtctc gggagtcccc gcttaaaccc        180

ttcttaaaac tcagcctggg gctgccaggc ctgggaatcc acatgaggcc cctggccatc        240

tggcttttca tcttcaacgt ctctcaacag atggggggct tctacctgtg ccagccgggg        300

cccccctctg agaaggcctg gcagcctggc tggacagtca atgtggaggg cagcggggag        360

ctgttccggt ggaatgtttc ggacctaggt ggcctgggct gtggcctgaa gaacaggtcc        420

tcagagggcc ccagctcccc ttccgggaag ctcatgagcc ccaagctgta tgtgtgggcc        480

aaagaccgcc ctgagatctg ggagggagag cctccgtgtc tcccaccgag ggacagcctg        540

aaccagagcc tcagccagga cctcaccatg gcccctggct ccacactctg gctgtcctgt        600

ggggtacccc ctgactctgt gtccaggggc cccctctcct ggacccatgt gcaccccaag        660

gggcctaagt cattgctgag cctagagctg aaggacgatc gcccggccag agatatgtgg        720

gtaatggaga cgggtctgtt gttgccccgg gccacagctc aagacgctgg aaagtattat        780

tgtcaccgtg gcaacctgac catgtcattc cacctggaga tcactgctcg gccagtacta        840

tggcactggc tgctgaggac tggtggctgg aaggtctcag ctgtgacttt ggcttatctg        900

atcttctgcc tgtgttccct tgtgggcatt cttcatcttc aaagagccct ggtcctgagg        960

aggaaaagat ga                                                            972


<210>    54
<211>    10450
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-F4-hCD19t vector


<400>    54
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcggaagtg       8040

aaagggcagc caaaacgtaa caccgccccg gttttccctg gaaattccat attggcacgc       8100

attctattgg ctgagctgcg ttcacgtggg tataagaggc gcgaccagcg tcggtaccgt       8160

cgcagtcttc ggtctgacca ccgtagaacg cagagcggcc gcatgccacc tcctcgcctc       8220

ctcttcttcc tcctcttcct cacccccatg gaagtcaggc ccgaggaacc tctagtggtg       8280

aaggtggaag agggagataa cgctgtgctg cagtgcctca aggggacctc agatggcccc       8340

actcagcagc tgacctggtc tcgggagtcc ccgcttaaac ccttcttaaa actcagcctg       8400

gggctgccag gcctgggaat ccacatgagg cccctggcca tctggctttt catcttcaac       8460

gtctctcaac agatgggggg cttctacctg tgccagccgg ggcccccctc tgagaaggcc       8520

tggcagcctg gctggacagt caatgtggag ggcagcgggg agctgttccg gtggaatgtt       8580

tcggacctag gtggcctggg ctgtggcctg aagaacaggt cctcagaggg ccccagctcc       8640

ccttccggga agctcatgag ccccaagctg tatgtgtggg ccaaagaccg ccctgagatc       8700

tgggagggag agcctccgtg tctcccaccg agggacagcc tgaaccagag cctcagccag       8760

gacctcacca tggcccctgg ctccacactc tggctgtcct gtggggtacc ccctgactct       8820

gtgtccaggg gccccctctc ctggacccat gtgcacccca aggggcctaa gtcattgctg       8880

agcctagagc tgaaggacga tcgcccggcc agagatatgt gggtaatgga gacgggtctg       8940

ttgttgcccc gggccacagc tcaagacgct ggaaagtatt attgtcaccg tggcaacctg       9000

accatgtcat tccacctgga gatcactgct cggccagtac tatggcactg gctgctgagg       9060

actggtggct ggaaggtctc agctgtgact ttggcttatc tgatcttctg cctgtgttcc       9120

cttgtgggca ttcttcatct tcaaagagcc ctggtcctga ggaggaaaag atgaacgcgt       9180

gaattcataa aataaaagat tttatttagt ctccagaaaa aggggggaat gaaagacccc       9240

acctgtaggt ttggcaagct agcttaagta acgccatttt gcaaggcatg gaaaaataca       9300

taactgagaa tagagaagtt cagatcaagg tcaggaacag atggaacagc tgaatatggg       9360

ccaaacagga tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatgga       9420

acagctgaat atgggccaaa caggatatct gtggtaagca gttcctgccc cggctcaggg       9480

ccaagaacag atggtcccca gatgcggtcc agccctcagc agtttctaga gaaccatcag       9540

atgtttccag ggtgccccaa ggacctgaaa tgaccctgtg ccttatttga actaaccaat       9600

cagttcgctt ctcgcttctg ttcgcgcgct tctgctcccc gagctcaata aaagagccca       9660

caacccctca ctcggggcgc cagtcctccg attgactgag tcgcccgggt acccgtgtat       9720

ccaataaacc ctcttgcagt tgcatccgac ttgtggtctc gctgttcctt gggagggtct       9780

cctctgagtg attgactacc cgtcagcggg ggtctttcat tgttacttaa agttacattg       9840

gcttccttga aataaacatg gagtattcag aatgtgtcat aaatatttct aattttaaga       9900

tagtatctcc attggctttc tactttttct tttatttttt tttgtcctct gtcttccatt       9960

tgttgttgtt gttgtttgtt tgtttgtttg ttggttggtt ggttaatttt tttttaaaga      10020

tcctacacta tagttcaagc tagactatta gctactctgt aacccagggt gaccttgaag      10080

tcatgggtag cctgctgttt tagccttccc acatctaaga ttacaggtat gagctatcat      10140

ttttggtata ttgattgatt gattgattga tgtgtgtgtg tgtgattgtg tttgtgtgtg      10200

tgactgtgaa aatgtgtgta tgggtgtgtg tgaatgtgtg tatgtatgtg tgtgtgtgag      10260

tgtgtgtgtg tgtgtgtgca tgtgtgtgtg tgtgactgtg tctatgtgta tgactgtgtg      10320

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg ttgtgaaaaa atattctatg      10380

gtagtgagag ccaacgctcc ggctcaggtg tcaggttggt ttttgagaca gagtctttca      10440

cttagcttgg                                                             10450


<210>    55
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hCD19t-SalI-R


<400>    55
tggtcgactc atcttttcct cctcaggacc agg                                      33


<210>    56
<211>    9406
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVe-F4-hCD19t vector


<400>    56
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacgtgat       1800

ggcgcgttca acgctctcaa aaccccctca agataagatt aacccgtgga agcccttaat       1860

agtcatggga gtcctgttag gagtagggat ggcagagagc ccccatcagg tctttaatgt       1920

aacctggaga gtcaccaacc tgatgactgg gcgtaccgcc aatgccacct ccctcctggg       1980

aactgtacaa gatgccttcc caaaattata ttttgatcta tgtgatctgg tcggagagga       2040

gtgggaccct tcagaccagg aaccgtatgt cgggtatggc tgcaagtacc ccgcagggag       2100

acagcggacc cggacttttg acttttacgt gtgccctggg cataccgtaa agtcggggtg       2160

tgggggacca ggagagggct actgtggtaa atgggggtgt gaaaccaccg gacaggctta       2220

ctggaagccc acatcatcgt gggacctaat ctcccttaag cgcggtaaca ccccctggga       2280

cacgggatgc tctaaagttg cctgtggccc ctgctacgac ctctccaaag tatccaattc       2340

cttccaaggg gctactcgag ggggcagatg caaccctcta gtcctagaat tcactgatgc       2400

aggaaaaaag gctaactggg acgggcccaa atcgtgggga ctgagactgt accggacagg       2460

aacagatcct attaccatgt tctccctgac ccggcaggtc cttaatgtgg gaccccgagt       2520

ccccataggg cccaacccag tattacccga ccaaagactc ccttcctcac caatagagat       2580

tgtaccggct ccacagccac ctagccccct caataccagt tacccccctt ccactaccag       2640

tacaccctca acctccccta caagtccaag tgtcccacag ccacccccag gaactggaga       2700

tagactacta gctctagtca aaggagccta tcaggcgctt aacctcacca atcccgacaa       2760

gacccaagaa tgttggctgt gcttagtgtc gggacctcct tattacgaag gagtagcggt       2820

cgtgggcact tataccaatc attccaccgc tccggccaac tgtacggcca cttcccaaca       2880

taagcttacc ctatctgaag tgacaggaca gggcctatgc atgggggcag tacctaaaac       2940

tcaccaggcc ttatgtaaca ccacccaaag cgccggctca ggatcctact accttgcagc       3000

acccgccgga acaatgtggg cttgcagcac tggattgact ccctgcttgt ccaccacggt       3060

gctcaatcta accacagatt attgtgtatt agttgaactc tggcccagag taatttacca       3120

ctcccccgat tatatgtatg gtcagcttga acagcgtacc aaatataaaa gagagccagt       3180

atcattgacc ctggcccttc tactaggagg attaaccatg ggagggattg cagctggaat       3240

agggacgggg accactgcct taattaaaac ccagcagttt gagcagcttc atgccgctat       3300

ccagacagac ctcaacgaag tcgaaaagtc aattaccaac ctagaaaagt cactgacctc       3360

gttgtctgaa gtagtcctac agaaccgcag aggcctagat ttgctattcc taaaggaggg       3420

aggtctctgc gcagccctaa aagaagaatg ttgtttttat gcagaccaca cggggctagt       3480

gagagacagc atggccaaat taagagaaag gcttaatcag agacaaaaac tatttgagac       3540

aggccaagga tggttcgaag ggctgtttaa tagatccccc tggtttacca ccttaatctc       3600

caccatcatg ggacctctaa tagtactctt actgatctta ctctttggac cttgcattct       3660

caatcgatta gtccaatttg ttaaagacag gatatcagtg gtccaggctc tagttttgac       3720

tcaacaatat caccagctga agcctataga gtacgagcca tagcacgtga aggctgccga       3780

ccccgggggt ggacatcctc tagactgcca tggcgcggat ctcgacgttt aaacggaagt       3840

gaaagggcag ccaaaacgta acaccgcccc ggttttccct ggaaattcca tattggcacg       3900

cattctattg gctgagctgc gttcacgtgg gtataagagg cgcgaccagc gtcggtaccg       3960

tcgcagtctt cggtctgacc accgtagaac gcagagcggc cgcatgccac ctcctcgcct       4020

cctcttcttc ctcctcttcc tcacccccat ggaagtcagg cccgaggaac ctctagtggt       4080

gaaggtggaa gagggagata acgctgtgct gcagtgcctc aaggggacct cagatggccc       4140

cactcagcag ctgacctggt ctcgggagtc cccgcttaaa cccttcttaa aactcagcct       4200

ggggctgcca ggcctgggaa tccacatgag gcccctggcc atctggcttt tcatcttcaa       4260

cgtctctcaa cagatggggg gcttctacct gtgccagccg gggcccccct ctgagaaggc       4320

ctggcagcct ggctggacag tcaatgtgga gggcagcggg gagctgttcc ggtggaatgt       4380

ttcggaccta ggtggcctgg gctgtggcct gaagaacagg tcctcagagg gccccagctc       4440

cccttccggg aagctcatga gccccaagct gtatgtgtgg gccaaagacc gccctgagat       4500

ctgggaggga gagcctccgt gtctcccacc gagggacagc ctgaaccaga gcctcagcca       4560

ggacctcacc atggcccctg gctccacact ctggctgtcc tgtggggtac cccctgactc       4620

tgtgtccagg ggccccctct cctggaccca tgtgcacccc aaggggccta agtcattgct       4680

gagcctagag ctgaaggacg atcgcccggc cagagatatg tgggtaatgg agacgggtct       4740

gttgttgccc cgggccacag ctcaagacgc tggaaagtat tattgtcacc gtggcaacct       4800

gaccatgtca ttccacctgg agatcactgc tcggccagta ctatggcact ggctgctgag       4860

gactggtggc tggaaggtct cagctgtgac tttggcttat ctgatcttct gcctgtgttc       4920

ccttgtgggc attcttcatc ttcaaagagc cctggtcctg aggaggaaaa gatgagtcga       4980

cccatcgaac atcgatggta ccagatccga taaaataaaa gattttattt agtctccaga       5040

aaaagggggg aatgaaagac cccacctgta ggtttggcaa gctagcttaa gtaacgccat       5100

tttgcaaggc atggaaaaat acataactga gaatagagaa gttcagatca aggtcaggaa       5160

cagatggaac agctgaatat gggccaaaca ggatatctgt ggtaagcagt tcctgccccg       5220

gctcagggcc aagaacagat ggaacagctg aatatgggcc aaacaggata tctgtggtaa       5280

gcagttcctg ccccggctca gggccaagaa cagatggtcc ccagatgcgg tccagccctc       5340

agcagtttct agagaaccat cagatgtttc cagggtgccc caaggacctg aaatgaccct       5400

gtgccttatt tgaactaacc aatcagttcg cttctcgctt ctgttcgcgc gcttctgctc       5460

cccgagctca ataaaagagc ccacaacccc tcactcgggg cgccagtcct ccgattgact       5520

gagtcgcccg ggtacccgtg tatccaataa accctcttgc agttgcatcc gacttgtggt       5580

ctcgctgttc cttgggaggg tctcctctga gtgattgact acccgtcagc gggggtcttt       5640

cacacatgca gcatgtatca aaattaattt ggtttttttt cttaagtatt tacattaaat       5700

ggccatagta cttaaagtta cattggcttc cttgaaataa acatggagta ttcagaatgt       5760

gtcataaata tttctaattt taagatagta tctccattgg ctttctactt tttcttttat       5820

ttttttttgt cctctgtctt ccatttgttg ttgttgttgt ttgtttgttt gtttgttggt       5880

tggttggtta attttttttt aaagatccta cactatagtt caagctagac tattagctac       5940

tctgtaaccc agggtgacct tgaagtcatg ggtagcctgc tgttttagcc ttcccacatc       6000

taagattaca ggtatgagct atcatttttg gtatatgatt gattgattga ttgatgtgtg       6060

tgtgtgtgat tgtgtttgtg tgtgtgactg tgaaaatgtg tgtatgggtg tgtgtgaatg       6120

tgtgtatgta tgtgtgtgtg tgagtgtgtg tgtgtgtgtg tgcatgtgtg tgtgtgtgac       6180

tgtgtctatg tgtatgactg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg       6240

tgtgttgtga aaaaatattc tatggtagtg agagccaacg ctccggctca ggtgtcaggt       6300

tggtttttga gacagagtct ttcacttagc ttggaattca ctggccgtcg ttttacaacg       6360

tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt       6420

cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag       6480

cctgaatggc gaatggcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc       6540

acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagcc       6600

ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc cggcatccgc       6660

ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt caccgtcatc       6720

accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat       6780

gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc       6840

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg       6900

ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc       6960

ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt       7020

gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct       7080

caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac       7140

ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact       7200

cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa       7260

gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga       7320

taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt       7380

tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga       7440

agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg       7500

caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat       7560

ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat       7620

tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc       7680

agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga       7740

tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc       7800

agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag       7860

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc       7920

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt       7980

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt       8040

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat       8100

accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga actctgtagc       8160

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa       8220

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg       8280

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag       8340

atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag       8400

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa       8460

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt       8520

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg       8580

gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc       8640

tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac       8700

cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ccaatacgca aaccgcctct       8760

ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc       8820

gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt       8880

acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac       8940

aggaaacagc tatgaccatg attacgccaa gctttgctcc taggagtttc ctaatacttc       9000

ccaaactcaa atatataaag catttgactt gttctatgcc ctagggggcg gggggaagct       9060

aagccagctt tttttaacat ttaaaatgtt aattccattt taaatgcaca gatgttttta       9120

tttcataagg gtttcaatgt gcatgaatgc tgcaatattc ctgttaccaa agctagtata       9180

aataaaaata gataaacgtg gaaattactt agagtttctg tcattaacgt ttccttcctc       9240

agttgacaac ataaatgcgc tgctgagcaa gccagtttgc atctgtcagg atcaatttcc       9300

cattatgcca gtcatattaa ttactagtca attagttgat ttttattttt gacatataca       9360

tgtgaatgaa agaccccacc tgtaggtttg gcaagctagc ttaagt                      9406


<210>    57
<211>    9535
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-mGM-CSF


<400>    57
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taacacgtga aggctgccga ccccgggggt ggaccatcct ctagactgtg ctcgacgttt       3960

aaaccgataa gcgttttttt caataacagg aaagtcccat tggagccaag tacattgagt       4020

caatagggac tttccaatgg gttttgccca gtacataagg tcaatgggag gtaagccaat       4080

gggtttttcc cattactggc acgtatactg agtcattagg gactttccaa tgggttttgc       4140

ccagtacata aggtcaatag gggtgaatca acaggaaagt cccattggag ccaagtacac       4200

tgagtcaata gggactttcc attgggtttt gcccagtaca aaaggtcaat agggggtgag       4260

tcaatgggtt tttcccatta ttggcacgta cataaggtca ataggggtga gtcattgggt       4320

ttttccagcc aatttaatta aaacgccatg tactttccca ccattgacgt caatgggcta       4380

ttgaaactaa tgcaacgtga cctttaaacg gtactttccc atagctgatt aatgggaaag       4440

taccgttctc gagccaatac acgtcaatgg gaagtgaaag ggcagccaaa acgtaacacc       4500

gccccggttt tcccctggaa attccatatt ggcacgcatt ctattggctg agctgcgttc       4560

tacgtgggta taagaggcgc gaccagcgtc ggtaccgtcg cagtcttcgg tctgaccacc       4620

gtagaacgca gaactctaga actagtggat cccccgggct gcaggaattc aggatgtggc       4680

tgcagaattt acttttcctg ggcattgtgg tctacagcct ctcagcaccc acccgctcac       4740

ccatcactgt cacccggcct tggaagcatg tagaggccat caaagaagcc ctgaacctcc       4800

tggatgacat gcctgtcacg ttgaatgaag aggtagaagt cgtctctaac gagttctcct       4860

tcaagaagct aacatgtgtg cagacccgcc tgaagatatt cgagcagggt ctacggggca       4920

atttcaccaa actcaagggc gccttgaaca tgacagccag ctactaccag acatactgcc       4980

ccccaactcc ggaaacggac tgtgaaacac aagttaccac ctatgcggat ttcatagaca       5040

gccttaaaac ctttctgact gatatcccct ttgaatgcaa aaaaccagtc caaaaatgag       5100

aattcgatat caagcttatc gatggggtac cagatccgat aaaataaaag attttattta       5160

gtctccagaa aaagggggga atgaaagacc ccacctgtag gtttggcaag ctagcttaag       5220

taacgccatt ttgcaaggca tggaaaaata cataactgag aatagagaag ttcagatcaa       5280

ggtcaggaac agatggaaca gctgaatatg ggccaaacag gatatctgtg gtaagcagtt       5340

cctgccccgg ctcagggcca agaacagatg gaacagctga atatgggcca aacaggatat       5400

ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggtccc cagatgcggt       5460

ccagccctca gcagtttcta gagaaccatc agatgtttcc agggtgcccc aaggacctga       5520

aatgaccctg tgccttattt gaactaacca atcagttcgc ttctcgcttc tgttcgcgcg       5580

cttctgctcc ccgagctcaa taaaagagcc cacaacccct cactcggggc gccagtcctc       5640

cgattgactg agtcgcccgg gtacccgtgt atccaataaa ccctcttgca gttgcatccg       5700

acttgtggtc tcgctgttcc ttgggagggt ctcctctgag tgattgacta cccgtcagcg       5760

ggggtctttc acacatgcag catgtatcaa aattaatttg gttttttttc ttaagtattt       5820

acattaaatg gccatagtac ttaaagttac attggcttcc ttgaaataaa catggagtat       5880

tcagaatgtg tcataaatat ttctaatttt aagatagtat ctccattggc tttctacttt       5940

ttcttttatt tttttttgtc ctctgtcttc catttgttgt tgttgttgtt tgtttgtttg       6000

tttgttggtt ggttggttaa ttttttttta aagatcctac actatagttc aagctagact       6060

attagctact ctgtaaccca gggtgacctt gaagtcatgg gtagcctgct gttttagcct       6120

tcccacatct aagattacag gtatgagcta tcatttttgg tatatgattg attgattgat       6180

tgatgtgtgt gtgtgtgatt gtgtttgtgt gtgtgactgt gaaaatgtgt gtatgggtgt       6240

gtgtgaatgt gtgtatgtat gtgtgtgtgt gagtgtgtgt gtgtgtgtgt gcatgtgtgt       6300

gtgtgtgact gtgtctatgt gtatgactgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt       6360

gtgtgtgtgt gtgttgtgaa aaaatattct atggtagtga gagccaacgc tccggctcag       6420

gtgtcaggtt ggtttttgag acagagtctt tcacttagct tggaattcac tggccgtcgt       6480

tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca       6540

tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca       6600

gttgcgcagc ctgaatggcg aatggcgcct gatgcggtat tttctcctta cgcatctgtg       6660

cggtatttca caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt       6720

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc       6780

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc       6840

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt       6900

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg       6960

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca       7020

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt       7080

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga       7140

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga       7200

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat       7260

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca       7320

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt       7380

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac       7440

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct       7500

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga       7560

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac       7620

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat       7680

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg       7740

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc       7800

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc       7860

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg       7920

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta       7980

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg       8040

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga       8100

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt       8160

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag       8220

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa       8280

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag       8340

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca       8400

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac       8460

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa       8520

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc       8580

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg       8640

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc       8700

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc       8760

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag       8820

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcaa       8880

accgcctctc cccgcgcgtt ggccgattca ttaatgcagc tggcacgaca ggtttcccga       8940

ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt tagctcactc attaggcacc       9000

ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga gcggataaca       9060

atttcacaca ggaaacagct atgaccatga ttacgccaag ctttgctcct aggagtttcc       9120

taatacttcc caaactcaaa tatataaagc atttgacttg ttctatgccc tagggggcgg       9180

ggggaagcta agccagcttt ttttaacatt taaaatgtta attccatttt aaatgcacag       9240

atgtttttat ttcataaggg tttcaatgtg catgaatgct gcaatattcc tgttaccaaa       9300

gctagtataa ataaaaatag ataaacgtgg aaattactta gagtttctgt cattaacgtt       9360

tccttcctca gttgacaaca taaatgcgct gctgagcaag ccagtttgca tctgtcagga       9420

tcaatttccc attatgccag tcatattaat tactagtcaa ttagttgatt tttatttttg       9480

acatatacat gtgaatgaaa gaccccacct gtaggtttgg caagctagct taagt            9535


<210>    58
<211>    30
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mGM-CSF-F-NotI


<400>    58
cggcggccgc aggatgtggc tgcagaattt                                          30


<210>    59
<211>    28
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    mGM-CSF-R-MluI


<400>    59
tggtcgactc atttttggac tggttttt                                            28


<210>    60
<211>    9907
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-F4-mGM-CSF vector


<400>    60
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcggaagtg       8040

aaagggcagc caaaacgtaa caccgccccg gttttccctg gaaattccat attggcacgc       8100

attctattgg ctgagctgcg ttcacgtggg tataagaggc gcgaccagcg tcggtaccgt       8160

cgcagtcttc ggtctgacca ccgtagaacg cagagcggcc gcaggatgtg gctgcagaat       8220

ttacttttcc tgggcattgt ggtctacagc ctctcagcac ccacccgctc acccatcact       8280

gtcacccggc cttggaagca tgtagaggcc atcaaagaag ccctgaacct cctggatgac       8340

atgcctgtca cgttgaatga agaggtagaa gtcgtctcta acgagttctc cttcaagaag       8400

ctaacatgtg tgcagacccg cctgaagata ttcgagcagg gtctacgggg caatttcacc       8460

aaactcaagg gcgccttgaa catgacagcc agctactacc agacatactg ccccccaact       8520

ccggaaacgg actgtgaaac acaagttacc acctatgcgg atttcataga cagccttaaa       8580

acctttctga ctgatatccc ctttgaatgc aaaaaaccag tccaaaaatg aacgcgtgaa       8640

ttcataaaat aaaagatttt atttagtctc cagaaaaagg ggggaatgaa agaccccacc       8700

tgtaggtttg gcaagctagc ttaagtaacg ccattttgca aggcatggaa aaatacataa       8760

ctgagaatag agaagttcag atcaaggtca ggaacagatg gaacagctga atatgggcca       8820

aacaggatat ctgtggtaag cagttcctgc cccggctcag ggccaagaac agatggaaca       8880

gctgaatatg ggccaaacag gatatctgtg gtaagcagtt cctgccccgg ctcagggcca       8940

agaacagatg gtccccagat gcggtccagc cctcagcagt ttctagagaa ccatcagatg       9000

tttccagggt gccccaagga cctgaaatga ccctgtgcct tatttgaact aaccaatcag       9060

ttcgcttctc gcttctgttc gcgcgcttct gctccccgag ctcaataaaa gagcccacaa       9120

cccctcactc ggggcgccag tcctccgatt gactgagtcg cccgggtacc cgtgtatcca       9180

ataaaccctc ttgcagttgc atccgacttg tggtctcgct gttccttggg agggtctcct       9240

ctgagtgatt gactacccgt cagcgggggt ctttcattgt tacttaaagt tacattggct       9300

tccttgaaat aaacatggag tattcagaat gtgtcataaa tatttctaat tttaagatag       9360

tatctccatt ggctttctac tttttctttt attttttttt gtcctctgtc ttccatttgt       9420

tgttgttgtt gtttgtttgt ttgtttgttg gttggttggt taattttttt ttaaagatcc       9480

tacactatag ttcaagctag actattagct actctgtaac ccagggtgac cttgaagtca       9540

tgggtagcct gctgttttag ccttcccaca tctaagatta caggtatgag ctatcatttt       9600

tggtatattg attgattgat tgattgatgt gtgtgtgtgt gattgtgttt gtgtgtgtga       9660

ctgtgaaaat gtgtgtatgg gtgtgtgtga atgtgtgtat gtatgtgtgt gtgtgagtgt       9720

gtgtgtgtgt gtgtgcatgt gtgtgtgtgt gactgtgtct atgtgtatga ctgtgtgtgt       9780

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg tgaaaaaata ttctatggta       9840

gtgagagcca acgctccggc tcaggtgtca ggttggtttt tgagacagag tctttcactt       9900

agcttgg                                                                 9907


<210>    61
<211>    9593
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    spRRVe-hGM-CSF


<400>    61
aacgccattt tgcaaggcat ggaaaaatac ataactgaga atagaaaagt tcagatcaag         60

gtcaggaaca gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc        120

ctgccccggc tcagggccaa gaacagatgg aacagctgaa tatgggccaa acaggatatc        180

tgtggtaagc agttcctgcc ccggctcagg gccaagaaca gatggtcccc agatgcggtc        240

cagccctcag cagtttctag agaaccatca gatgtttcca gggtgcccca aggacctgaa        300

atgaccctgt gccttatttg aactaaccaa tcagttcgct tctcgcttct gttcgcgcgc        360

ttatgctccc cgagctcaat aaaagagccc acaacccctc actcggggcg ccagtcctcc        420

gattgactga gtcgcccggg tacccgtgta tccaataaac cctcttgcag ttgcatccga        480

cttgtggtct cgctgttcct tgggagggtc tcctctgagt gattgactac ccgtcagcgg        540

gggtctttca tttgggggct cgtccgggat cgggagaccc ctgcccaggg accaccgacc        600

caccaccggg aggtaagctg gccagcaact tatctgtgtc tgtccgattg tctagtgtct        660

atgactgatt ttatgcgcct gcgtcggtac tagttagcta actagctctg tatctggcgg        720

acccgtggtg gaactgacga gttcggaaca cccggccgca accctgggag acgtcccagg        780

gacttcgggg gccgtttttg tggcccgacc tgagtcctaa aatcccgatc gtttaggact        840

ctttggtgca ccccccttag aggagggata tgtggttctg gtaggagacg agaacctaaa        900

acagttcccg cctccgtctg aatttttgct ttcggtttgg gaccgaagcc gcgccgcgcg        960

tcttgtctgc tgcagcatcg ttctgtgttg tctctgtctg actgtgtttc tgtatttgtc       1020

tgaaaatatg ggcccgggct agcctgttac cactccctta agtttgacct taggtcactg       1080

gaaagatgtc gagcggatcg ctcacaacca gtcggtagat gtcaagaaga gacgttgggt       1140

taccttctgc tctgcagaat ggccaacctt taacgtcgga tggccgcgag acggcacctt       1200

taaccgagac ctcactaccc aggttaagat caaggtcttt tcacctggcc cgcatggaca       1260

cccagaccag gtggggtaca tcgtgacctg ggaagccttg gcttttgacc cccctccctg       1320

ggtcaagccc tttgtacacc ctaagcctcc gcctcctctt cctccatccg ccccgtctct       1380

cccccttgaa cctcctcgtt cgaccccgcc tcgatcctcc ctttatccag ccctcactcc       1440

ttctctaggc gcccccatat ggccatatga gatcttatat ggggcacccc cgccccttgt       1500

aaacttccct gaccctgaca tgacaagagt tactaacagc ccctctctcc aagctcactt       1560

acaggctctc tacttagtcc agcacgaagt ctggagacct ctggcggcag cctaccaaga       1620

acaactggac cgaccggtgg tacctcaccc ttaccgagtc ggcgacacag tgtgggtccg       1680

ccgacaccag actaagaacc tagaacctcg ctggaaagga ccttacacag tcctgctgac       1740

cacccccacc gccctcaaag tagacggcat cgcagcttgg atacacgccg cccacaattc       1800

gatcatacct ggtgttgctg actaccccga ccgcggtaaa agtcgatggt attgctgcct       1860

gggtccatgc ttctcacctc aaacctgcac caccttcggc accagatgag tcctgggagc       1920

tggaaaagac tgatcatcct cttaagctgc gtattcggcg gcggcgggac gagtctgcaa       1980

aataagaacc cccaccagcc catgaccctc acttggcagg tactgtccca aactggagac       2040

gttgtctggg atacaaaggc agtccagccc ccttggactt ggtggcccac acttaaacct       2100

gatgtatgtg ccttggcggc tagtcttgag tcctgggata tcccgggaac cgatgtctcg       2160

tcctctaaac gagtcagacc tccggactca gactatactg ccgcttataa gcaaatcacc       2220

tggggagcca tagggtgcag ctaccctcgg gctaggacta gaatggcaag ctctaccttc       2280

tacgtatgtc cccgggatgg ccggaccctt tcagaagcta gaaggtgcgg ggggctagaa       2340

tccctatact gtaaagaatg ggattgtgag accacgggga ccggttattg gctatctaaa       2400

tcctcaaaag acctcataac tgtaaaatgg gaccaaaata gcgaatggac tcaaaaattt       2460

caacagtgtc accagaccgg ctggtgtaac ccccttaaaa tagatttcac agacaaagga       2520

aaattatcca aggactggat aacgggaaaa acctggggat taagattcta tgtgtctgga       2580

catccaggcg tacagttcac cattcgctta aaaatcacca acatgccagc tgtggcagta       2640

ggtcctgacc tcgtccttgt ggaacaagga cctcctagaa cgtccctcgc tctcccacct       2700

cctcttcccc caagggaagc gccaccgcca tctctccccg actctaactc cacagccctg       2760

gcgactagtg cacaaactcc cacggtgaga aaaacaattg ttaccctaaa cactccgcct       2820

cccaccacag gcgacagact ttttgatctt gtgcaggggg ccttcctaac cttaaatgct       2880

accaacccag gggccactga gtcttgctgg ctttgtttgg ccatgggccc cccttattat       2940

gaagcaatag cctcatcagg agaggtcgcc tactccaccg accttgaccg gtgccgctgg       3000

gggacccaag gaaagctcac cctcactgag gtctcaggac acgggttgtg cataggaaag       3060

gtgcccttta cccatcagca tctctgcaat cagaccctat ccatcaattc ctccggagac       3120

catcagtatc tgctcccctc caaccatagc tggtgggctt gcagcactgg cctcacccct       3180

tgcctctcca cctcagtttt taatcagact agagatttct gtatccaggt ccagctgatt       3240

cctcgcatct attactatcc tgaagaagtt ttgttacagg cctatgacaa ttctcacccc       3300

aggactaaaa gagaggctgt ctcacttacc ctagctgttt tactggggtt gggaatcacg       3360

gcgggaatag gtactggttc aactgcctta attaaaggac ctatagacct ccagcaaggc       3420

ctgacaagcc tccagatcgc catagatgct gacctccggg ccctccaaga ctcagtcagc       3480

aagttagagg actcactgac ttccctgtcc gaggtagtgc tccaaaatag gagaggcctt       3540

gacttgctgt ttctaaaaga aggtggcctc tgtgcggccc taaaggaaga gtgctgtttt       3600

tacatagacc actcaggtgc agtacgggac tccatgaaaa aactcaaaga aaaactggat       3660

aaaagacagt tagagcgcca gaaaagccaa aactggtatg aaggatggtt caataactcc       3720

ccttggttca ctaccctgct atcaaccatc gctgggcccc tattactcct ccttctgttg       3780

ctcatcctcg ggccatgcat catcaataag ttagttcaat tcatcaatga taggataagt       3840

gcagttaaaa ttctggtcct tagacaaaaa tatcaggccc tagagaacga aggtaacctt       3900

taattttgct ctaagattag agctattcac aagagaaatg gggatcacta gtgaattaaa       3960

caacaggaaa gttccattgg agccaagtac attgagtcaa tagggacttt ccaatgggtt       4020

ttgcccagta cataaggtca atgggaggta agccaatggg tttttcccat tactggcacg       4080

tatactgagt cattagggac tttccaatgg gttttgccca gtacataagg tcaatagggg       4140

tgaatcaaca ggaaagtccc attggagcca agtacactga gtcaataggg actttccatt       4200

gggttttgcc cagtacaaaa ggtcaatagg gggtgagtca atgggttttt cccattattg       4260

gcacgtacat aaggtcaata ggggtgagtc attgggtttt tccagccaat ttaattaaaa       4320

cgccatgtac tttcccacca ttgacgtcaa tgggctattg aaactaatgc aacgtgacct       4380

ttaaacggta ctttcccata gctgattaat gggaaagtac cgttctcgag ccaatacacg       4440

tcaatgggaa gtgaaagggc agccaaaacg taacaccgcc ccggttttcc ctggaaattc       4500

catattggca cgcattctat tggctgagct gcgttctacg tgggtataag aggcgcgacc       4560

agcgtcggta ccgtcgcagt cttcggtctg accaccgtag aacgcagaac tctagaacta       4620

gtcgggatcc gttaacatgt ggctgcagag cctgctgctc ttgggcactg tggcctgcag       4680

catctctgca cccgcccgct cgcccagccc cagcacgcag ccctgggagc atgtgaatgc       4740

catccaggag gcccggcgtc tcctgaacct gagtagagac actgctgctg agatgaatga       4800

aacagtagaa gtcatctcag aaatgtttga cctccaggag ccgacctgcc tacagacccg       4860

cctggagctg tacaagcagg gcctgcgggg cagcctcacc aagctcaagg gccccttgac       4920

catgatggcc agccactaca agcagcactg ccctccaacc ccggaaactt cctgtgcaac       4980

ccagattatc acctttgaaa gtttcaaaga gaacctgaag gactttctgc ttgtcatccc       5040

ctttgactgc tgggagccag tccaggagtg agttaacatc gatggggtac cagatccgga       5100

ttagtccaat ttgttaaaga caggatatca gtggtccagg ctctagtttt gactcaacaa       5160

tatcaccagc tgaagcctat agagtacgag ccatagataa aataaaagat tttatttagt       5220

ctccagaaaa aggggggaat gaaagacccc acctgtaggt ttggcaagct agcttaagta       5280

acgccatttt gcaaggcatg gaaaaataca taactgagaa tagagaagtt cagatcaagg       5340

tcaggaacag atggaacagc tgaatatggg ccaaacagga tatctgtggt aagcagttcc       5400

tgccccggct cagggccaag aacagatgga acagctgaat atgggccaaa caggatatct       5460

gtggtaagca gttcctgccc cggctcaggg ccaagaacag atggtcccca gatgcggtcc       5520

agccctcagc agtttctaga gaaccatcag atgtttccag ggtgccccaa ggacctgaaa       5580

tgaccctgtg ccttatttga actaaccaat cagttcgctt ctcgcttctg ttcgcgcgct       5640

tctgctcccc gagctcaata aaagagccca caacccctca ctcggggcgc cagtcctccg       5700

attgactgag tcgcccgggt acccgtgtat ccaataaacc ctcttgcagt tgcatccgac       5760

ttgtggtctc gctgttcctt gggagggtct cctctgagtg attgactacc cgtcagcggg       5820

ggtctttcac acatgcagca tgtatcaaaa ttaatttggt tttttttctt aagtatttac       5880

attaaatggc catagtactt aaagttacat tggcttcctt gaaataaaca tggagtattc       5940

agaatgtgtc ataaatattt ctaattttaa gatagtatct ccattggctt tctacttttt       6000

cttttatttt tttttgtcct ctgtcttcca tttgttgttg ttgttgtttg tttgtttgtt       6060

tgttggttgg ttggttaatt tttttttaaa gatcctacac tatagttcaa gctagactat       6120

tagctactct gtaacccagg gtgaccttga agtcatgggt agcctgctgt tttagccttc       6180

ccacatctaa gattacaggt atgagctatc atttttggta tatgattgat tgattgattg       6240

atgtgtgtgt gtgtgattgt gtttgtgtgt gtgactgtga aaatgtgtgt atgggtgtgt       6300

gtgaatgtgt gtatgtatgt gtgtgtgtga gtgtgtgtgt gtgtgtgtgc atgtgtgtgt       6360

gtgtgactgt gtctatgtgt atgactgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt       6420

gtgtgtgtgt gttgtgaaaa aatattctat ggtagtgaga gccaacgctc cggctcaggt       6480

gtcaggttgg tttttgagac agagtctttc acttagcttg gaattcactg gccgtcgttt       6540

tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc       6600

cccctttcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt       6660

tgcgcagcct gaatggcgaa tggcgcctga tgcggtattt tctccttacg catctgtgcg       6720

gtatttcaca ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa       6780

gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt ctgctcccgg       6840

catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag aggttttcac       6900

cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt ttataggtta       6960

atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg       7020

gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat       7080

aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc       7140

gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa       7200

cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac       7260

tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga       7320

tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag       7380

agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca       7440

cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca       7500

tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa       7560

ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc       7620

tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa       7680

cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag       7740

actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct       7800

ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac       7860

tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa       7920

ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt       7980

aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat       8040

ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg       8100

agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc       8160

ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg       8220

tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag       8280

cgcagatacc aaatactgtt cttctagtgt agccgtagtt aggccaccac ttcaagaact       8340

ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg       8400

gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc       8460

ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg       8520

aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg       8580

cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag       8640

ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc       8700

gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct       8760

ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc       8820

ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc       8880

gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgccca atacgcaaac       8940

cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact       9000

ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc       9060

aggctttaca ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat       9120

ttcacacagg aaacagctat gaccatgatt acgccaagct ttgctcctag gagtttccta       9180

atacttccca aactcaaata tataaagcat ttgacttgtt ctatgcccta gggggcgggg       9240

ggaagctaag ccagcttttt ttaacattta aaatgttaat tccattttaa atgcacagat       9300

gtttttattt cataagggtt tcaatgtgca tgaatgctgc aatattcctg ttaccaaagc       9360

tagtataaat aaaaatagat aaacgtggaa attacttaga gtttctgtca ttaacgtttc       9420

cttcctcagt tgacaacata aatgcgctgc tgagcaagcc agtttgcatc tgtcaggatc       9480

aatttcccat tatgccagtc atattaatta ctagtcaatt agttgatttt tatttttgac       9540

atatacatgt gaatgaaaga ccccacctgt aggtttggca agctagctta agt              9593


<210>    62
<211>    28
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hGM-CSF-F-NotI


<400>    62
cggcggccgc aggatgtggc tgcagagc                                            28


<210>    63
<211>    28
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hGM-CSF-R-MluI


<400>    63
tggtcgactc actcctggac tggctccc                                            28


<210>    64
<211>    9916
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-F4-hGM-CSF vector


<400>    64
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcggaagtg       8040

aaagggcagc caaaacgtaa caccgccccg gttttccctg gaaattccat attggcacgc       8100

attctattgg ctgagctgcg ttcacgtggg tataagaggc gcgaccagcg tcggtaccgt       8160

cgcagtcttc ggtctgacca ccgtagaacg cagagcggcc gcaggatgtg gctgcagagc       8220

ctgctgctct tgggcactgt ggcctgcagc atctctgcac ccgcccgctc gcccagcccc       8280

agcacgcagc cctgggagca tgtgaatgcc atccaggagg cccggcgtct cctgaacctg       8340

agtagagaca ctgctgctga gatgaatgaa acagtagaag tcatctcaga aatgtttgac       8400

ctccaggagc cgacctgcct acagacccgc ctggagctgt acaagcaggg cctgcggggc       8460

agcctcacca agctcaaggg ccccttgacc atgatggcca gccactacaa gcagcactgc       8520

cctccaaccc cggaaacttc ctgtgcaacc cagattatca cctttgaaag tttcaaagag       8580

aacctgaagg actttctgct tgtcatcccc tttgactgct gggagccagt ccaggagtga       8640

acgcgtgaat tcataaaata aaagatttta tttagtctcc agaaaaaggg gggaatgaaa       8700

gaccccacct gtaggtttgg caagctagct taagtaacgc cattttgcaa ggcatggaaa       8760

aatacataac tgagaataga gaagttcaga tcaaggtcag gaacagatgg aacagctgaa       8820

tatgggccaa acaggatatc tgtggtaagc agttcctgcc ccggctcagg gccaagaaca       8880

gatggaacag ctgaatatgg gccaaacagg atatctgtgg taagcagttc ctgccccggc       8940

tcagggccaa gaacagatgg tccccagatg cggtccagcc ctcagcagtt tctagagaac       9000

catcagatgt ttccagggtg ccccaaggac ctgaaatgac cctgtgcctt atttgaacta       9060

accaatcagt tcgcttctcg cttctgttcg cgcgcttctg ctccccgagc tcaataaaag       9120

agcccacaac ccctcactcg gggcgccagt cctccgattg actgagtcgc ccgggtaccc       9180

gtgtatccaa taaaccctct tgcagttgca tccgacttgt ggtctcgctg ttccttggga       9240

gggtctcctc tgagtgattg actacccgtc agcgggggtc tttcattgtt acttaaagtt       9300

acattggctt ccttgaaata aacatggagt attcagaatg tgtcataaat atttctaatt       9360

ttaagatagt atctccattg gctttctact ttttctttta tttttttttg tcctctgtct       9420

tccatttgtt gttgttgttg tttgtttgtt tgtttgttgg ttggttggtt aatttttttt       9480

taaagatcct acactatagt tcaagctaga ctattagcta ctctgtaacc cagggtgacc       9540

ttgaagtcat gggtagcctg ctgttttagc cttcccacat ctaagattac aggtatgagc       9600

tatcattttt ggtatattga ttgattgatt gattgatgtg tgtgtgtgtg attgtgtttg       9660

tgtgtgtgac tgtgaaaatg tgtgtatggg tgtgtgtgaa tgtgtgtatg tatgtgtgtg       9720

tgtgagtgtg tgtgtgtgtg tgtgcatgtg tgtgtgtgtg actgtgtcta tgtgtatgac       9780

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgttgt gaaaaaatat       9840

tctatggtag tgagagccaa cgctccggct caggtgtcag gttggttttt gagacagagt       9900

ctttcactta gcttgg                                                       9916


<210>    65
<211>    435
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    human codon optimized hGM-CSF polynucleotide sequence


<400>    65
atgtggcttc aaagtttgtt gctccttgga accgtcgctt gctctattag cgcacccgca         60

cgcagcccaa gtccttccac gcagccttgg gaacatgtta atgcgatcca agaagcacgg        120

cgcctcttga atctttcccg agacacggcg gcagaaatga atgagacagt tgaagtcatt        180

tcagagatgt ttgatctcca agaacctact tgtttgcaga ctcgactcga actttacaag        240

cagggtctcc ggggaagttt gaccaagctc aagggtcccc ttacgatgat ggcgtcccac        300

tacaagcaac actgcccccc gacaccagaa acgtcatgtg ctacccaaat cattaccttt        360

gaatcattca aggagaacct caaggatttt ctgttggtca taccattcga ctgttgggag        420

cccgtgcagg aatga                                                         435


<210>    66
<211>    9913
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    sRRVgp-F4-hopt-GM-CSF vector


<400>    66
catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt         60

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg        120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg        180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag        240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc        300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa        360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg        420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc        480

taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga agccagttac        540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg        600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt        660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt        720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa        780

atcaatctaa agtatatatg agtaacctga tcaggactct tccttttcat gaacaataaa        840

actgtctgct tacataaaca gtaatacaag gggtgttatg agccatattc aacgggaaac        900

gtcttgctct aggccgcgat taaattccaa catggatgct gatttatatg ggtataaatg        960

ggctcgcgat aatgtcgggc aatcaggtgc gacaatctat cgattgtatg ggaagcccga       1020

tgcgccagag ttgtttctga aacatggcaa aggtagcgtt gccaatgatg ttacagatga       1080

gatggtcaga ctaaactggc tgacggaatt tatgcctctt ccgaccatca agcattttat       1140

ccgtactcct gatgatgcat ggttactcac cactgcgatc cccgggaaaa cagcattcca       1200

ggtattagaa gaatatcctg attcaggtga aaatattgtt gatgcgctgg cagtgttcct       1260

gcgccggttg cattcgattc ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg       1320

tctcgctcag gcgcaatcac gaatgaataa cggtttggtt gatgcgagtg attttgatga       1380

cgagcgtaat ggctggcctg ttgaacaagt ctggaaagaa atgcataaac ttttgccatt       1440

ctcaccggat tcagtcgtca ctcatggtga tttctcactt gataacctta tttttgacga       1500

ggggaaatta ataggttgta ttgatgttgg acgagtcgga atcgcagacc gataccagga       1560

tcttgccatc ctatggaact gcctcggtga gttttctcct tcattacaga aacggctttt       1620

tcaaaaatat ggtattgata atcctgatat gaataaattg cagtttcatt tgatgctcga       1680

tgagtttttc taagaatttg tgaatgaaag accccacctg taggtttggc aagctagctt       1740

aagtaacgcc attttgcaag gcatggaaaa atacataact gagaatagaa aagttcagat       1800

caaggtcagg aacagatgga acagctgaat atgggccaaa caggatatct gtggtaagca       1860

gttcctgccc cggctcaggg ccaagaacag atggaacagc tgaatatggg ccaaacagga       1920

tatctgtggt aagcagttcc tgccccggct cagggccaag aacagatggt ccccagatgc       1980

ggtccagccc tcagcagttt ctagagaacc atcagatgtt tccagggtgc cccaaggacc       2040

tgaaatgacc ctgtgcctta tttgaactaa ccaatcagtt cgcttctcgc ttctgttcgc       2100

gcgcttatgc tccccgagct caataaaaga gcccacaacc cctcactcgg ggcgccagtc       2160

ctccgattga ctgagtcgcc cgggtacccg tgtatccaat aaaccctctt gcagttgcat       2220

ccgacttgtg gtctcgctgt tccttgggag ggtctcctct gagtgattga ctacccgtca       2280

gcgggggtct ttcatttggg ggctcgtccg ggatcgggag acccctgccc agggaccacc       2340

gacccaccac cgggaggtaa gctggccagc aacttatctg tgtctgtccg attgtctagt       2400

gtctatgact gattttatgc gcctgcgtcg gtactagtta gctaactagc tctgtatctg       2460

gcggacccgt ggtggaactg acgagttcgg aacacccggc cgcaaccctg ggagacgtcc       2520

cagggacttc gggggccgtt tttgtggccc gacctgagtc caaaaatccc gatcgttttg       2580

gactctttgg tgcacccccc ttagaggagg gatatgtggt tctggtagga gacgagaacc       2640

taaaacagtt cccgcctccg tctgaatttt tgctttcggt ttgggaccga agccgcgccg       2700

cgcgtcttgt ctgctgcagc atcgttctgt gttgtctctg tctgactgtg tttctgtatt       2760

tgtctgagaa tatgggccag actgttacca ctcccttaag tttgacctta ggtcactgga       2820

aagatgtcga gcggatcgct cacaaccagt cggtagatgt caagaagaga cgttgggtta       2880

ccttctgctc tgcagaatgg ccaaccttta acgtcggatg gccgcgagac ggcaccttta       2940

accgagacct catcacccag gttaagatca aggtcttttc acctggcccg catggacacc       3000

cagaccaggt cccctacatc gtgacctggg aagccttggc ttttgacccc cctccctggg       3060

tcaagccctt tgtacaccct aagcctccgc ctcctcttcc tccatccgcc ccgtctctcc       3120

cccttgaacc tcctcgttcg accccgcctc gatcctccct ttatccagcc ctcactcctt       3180

ctctaggcgc caaacctaaa cctcaagttc tttctgacag tggggggccg ctcatcgacc       3240

tacttacaga agaccccccg ccttataggg acccaagacc acccccttcc gacagggacg       3300

gaaatggtgg agaagcgacc cctgcgggag aggcaccgga cccctcccca atggcatctc       3360

gcctacgtgg gagacgggag ccccctgtgg ccgactccac tacctcgcag gcattccccc       3420

tccgcgcagg aggaaacgga cagcttcaat actggccgtt ctcctcttct gacctttaca       3480

actggaaaaa taataaccct tctttttctg aagatccagg taaactgaca gctctgatcg       3540

agtctgttct catcacccat cagcccacct gggacgactg tcagcagctg ttggggactc       3600

tgctgaccgg agaagaaaaa caacgggtgc tcttagaggc tagaaaggcg gtgcggggcg       3660

atgatgggcg ccccactcaa ctgcccaatg aagtcgatgc cgcttttccc ctcgagcgcc       3720

cagactggga ttacaccacc caggcaggta ggaaccacct agtccactat cgccagttgc       3780

tcctagcggg tctccaaaac gcgggcagaa gccccaccaa tttggccaag gtaaaaggaa       3840

taacacaagg gcccaatgag tctccctcgg ccttcctaga gagacttaag gaagcctatc       3900

gcaggtacac tccttatgac cctgaggacc cagggcaaga aactaatgtg tctatgtctt       3960

tcatttggca gtctgcccca gacattggga gaaagttaga gaggttagaa gatttaaaaa       4020

acaagacgct tggagatttg gttagagagg cagaaaagat ctttaataaa cgagaaaccc       4080

cggaagaaag agaggaacgt atcaggagag aaacagagga aaaagaagaa cgccgtagga       4140

cagaggatga gcagaaagag aaagaaagag atcgtaggag acatagagag atgagcaagc       4200

tattggccac tgtcgttagt ggacagaaac aggatagaca gggaggagaa cgaaggaggt       4260

cccaactcga tcgcgaccag tgtgcctact gcaaagaaaa ggggcactgg gctaaagatt       4320

gtcccaagaa accacgagga cctcggggac caagacccca gacctccctc ctgaccctag       4380

atgactaggg aggtcagggt caggagcccc cccctgaacc caggataacc ctcaaagtcg       4440

gggggcaacc cgtcaccttc ctggtagata ctggggccca acactccgtg ctgacccaaa       4500

atcctggacc cctaagtgat aagtctgcct gggtccaagg ggctactgga ggaaagcggt       4560

atcgctggac cacggatcgc aaagtacatc tagctaccgg taaggtcacc cactctttcc       4620

tccatgtacc agactgtccc tatcctctgt taggaagaga tttgctgact aaactaaaag       4680

cccaaatcca ctttgaggga tcaggagctc aggttatggg accaatgggg cagcccctgc       4740

aagtgttgac cctaaatata gaagatgagc atcggctaca tgagacctca aaagagccag       4800

atgtttctct agggtccaca tggctgtctg attttcctca ggcctgggcg gaaaccgggg       4860

gcatgggact ggcagttcgc caagctcctc tgatcatacc tctgaaagca acctctaccc       4920

ccgtgtccat aaaacaatac cccatgtcac aagaagccag actggggatc aagccccaca       4980

tacagagact gttggaccag ggaatactgg taccctgcca gtccccctgg aacacgcccc       5040

tgctacccgt taagaaacca gggactaatg attataggcc tgtccaggat ctgagagaag       5100

tcaacaagcg ggtggaagac atccacccca ccgtgcccaa cccttacaac ctcttgagcg       5160

ggctcccacc gtcccaccag tggtacactg tgcttgattt aaaggatgcc tttttctgcc       5220

tgagactcca ccccaccagt cagcctctct tcgcctttga gtggagagat ccagagatgg       5280

gaatctcagg acaattgacc tggaccagac tcccacaggg tttcaaaaac agtcccaccc       5340

tgtttgatga ggcactgcac agagacctag cagacttccg gatccagcac ccagacttga       5400

tcctgctaca gtacgtggat gacttactgc tggccgccac ttctgagcta gactgccaac       5460

aaggtactcg ggccctgtta caaaccctag ggaacctcgg gtatcgggcc tcggccaaga       5520

aagcccaaat ttgccagaaa caggtcaagt atctggggta tcttctaaaa gagggtcaga       5580

gatggctgac tgaggccaga aaagagactg tgatggggca gcctactccg aagacccctc       5640

gacaactaag ggagttccta gggacggcag gcttctgtcg cctctggatc cctgggtttg       5700

cagaaatggc agcccccttg taccctctca ccaaaacggg gactctgttt aattggggcc       5760

cagaccaaca aaaggcctat caagaaatca agcaagctct tctaactgcc ccagccctgg       5820

ggttgccaga tttgactaag ccctttgaac tctttgtcga cgagaagcag ggctacgcca       5880

aaggtgtcct aacgcaaaaa ctgggacctt ggcgtcggcc ggtggcctac ctgtccaaaa       5940

agctagaccc agtagcagct gggtggcccc cttgcctacg gatggtagca gccattgccg       6000

tactgacaaa ggatgcaggc aagctaacca tgggacagcc actagtcatt ctggcccccc       6060

atgcagtaga ggcactagtc aaacaacccc ccgaccgctg gctttccaac gcccggatga       6120

ctcactatca ggccttgctt ttggacacgg accgggtcca gttcggaccg gtggtagccc       6180

tgaacccggc tacgctgctc ccactgcctg aggaagggct gcaacacaac tgccttgata       6240

tcctggccga agcccacgga acccgacccg acctaacgga ccagccgctc ccagacgccg       6300

accacacctg gtacacggat ggaagcagtc tcttacaaga gggacagcgt aaggcgggag       6360

ctgcggtgac caccgagacc gaggtaatct gggctaaagc cctgccagcc gggacatccg       6420

ctcagcgggc tgaactgata gcactcaccc aggccctaaa gatggcagaa ggtaagaagc       6480

taaatgttta tactgatagc cgttatgctt ttgctactgc ccatatccat ggagaaatat       6540

acagaaggcg tgggttgctc acatcagaag gcaaagagat caaaaataaa gacgagatct       6600

tggccctact aaaagccctc tttctgccca aaagacttag cataatccat tgtccaggac       6660

atcaaaaggg acacagcgcc gaggctagag gcaaccggat ggctgaccaa gcggcccgaa       6720

aggcagccat cacagagact ccagacacct ctaccctcct catagaaaat tcatcaccct       6780

acacctcaga acattttcat tacacagtga ctgatataaa ggacctaacc aagttggggg       6840

ccatttatga taaaacaaag aagtattggg tctaccaagg aaaacctgtg atgcctgacc       6900

agtttacttt tgaattatta gactttcttc atcagctgac tcacctcagc ttctcaaaaa       6960

tgaaggctct cctagagaga agccacagtc cctactacat gctgaaccgg gatcgaacac       7020

tcaaaaatat cactgagacc tgcaaagctt gtgcacaagt caacgccagc aagtctgccg       7080

ttaaacaggg aactagggtc cgcgggcatc ggcccggcac tcattgggag atcgatttca       7140

ccgagataaa gcccggattg tatggctata aatatcttct agtttttata gatacctttt       7200

ctggctggat agaagccttc ccaaccaaga aagaaaccgc caaggtcgta accaagaagc       7260

tactagagga gatcttcccc aggttcggca tgcctcaggt attgggaact gacaatgggc       7320

ctgccttcgt ctccaaggtg agtcagacag tggccgatct gttggggatt gattggaaat       7380

tacattgtgc atacagaccc caaagctcag gccaggtaga aagaatgaat agaaccatca       7440

aggagacttt aactaaatta acgcttgcaa ctggctctag agactgggtg ctcctactcc       7500

ccttagccct gtaccgagcc cgcaacacgc cgggccccca tggcctcacc ccatatgaga       7560

tcttatatgg ggcacccccg ccccttgtaa acttccctga ccctgacatg acaagagtta       7620

ctaacagccc ctctctccaa gctcacttac aggctctcta cttagtccag cacgaagtct       7680

ggagacctct ggcggcagcc taccaagaac aactggaccg accggtggta cctcaccctt       7740

accgagtcgg cgacacagtg tgggtccgcc gacaccagac taagaaccta gaacctcgct       7800

ggaaaggacc ttacacagtc ctgctgacca cccccaccgc cctcaaagta gacggcatcg       7860

cagcttggat acacgccgcc cacgtgaagg ctgccgaccc cgggggtgga ccatcctcta       7920

gactgacatg gcgcgttcaa cgctctcaaa accccttaaa aataaggtta acccgcgagg       7980

ccccctaatc cccttaattc ttctgatgct cagaggggtc agtaaacgaa ttcggaagtg       8040

aaagggcagc caaaacgtaa caccgccccg gttttccctg gaaattccat attggcacgc       8100

attctattgg ctgagctgcg ttcacgtggg tataagaggc gcgaccagcg tcggtaccgt       8160

cgcagtcttc ggtctgacca ccgtagaacg cagagcggcc gcatgtggct tcaaagtttg       8220

ttgctccttg gaaccgtcgc ttgctctatt agcgcacccg cacgcagccc aagtccttcc       8280

acgcagcctt gggaacatgt taatgcgatc caagaagcac ggcgcctctt gaatctttcc       8340

cgagacacgg cggcagaaat gaatgagaca gttgaagtca tttcagagat gtttgatctc       8400

caagaaccta cttgtttgca gactcgactc gaactttaca agcagggtct ccggggaagt       8460

ttgaccaagc tcaagggtcc ccttacgatg atggcgtccc actacaagca acactgcccc       8520

ccgacaccag aaacgtcatg tgctacccaa atcattacct ttgaatcatt caaggagaac       8580

ctcaaggatt ttctgttggt cataccattc gactgttggg agcccgtgca ggaatgaacg       8640

cgtgaattca taaaataaaa gattttattt agtctccaga aaaagggggg aatgaaagac       8700

cccacctgta ggtttggcaa gctagcttaa gtaacgccat tttgcaaggc atggaaaaat       8760

acataactga gaatagagaa gttcagatca aggtcaggaa cagatggaac agctgaatat       8820

gggccaaaca ggatatctgt ggtaagcagt tcctgccccg gctcagggcc aagaacagat       8880

ggaacagctg aatatgggcc aaacaggata tctgtggtaa gcagttcctg ccccggctca       8940

gggccaagaa cagatggtcc ccagatgcgg tccagccctc agcagtttct agagaaccat       9000

cagatgtttc cagggtgccc caaggacctg aaatgaccct gtgccttatt tgaactaacc       9060

aatcagttcg cttctcgctt ctgttcgcgc gcttctgctc cccgagctca ataaaagagc       9120

ccacaacccc tcactcgggg cgccagtcct ccgattgact gagtcgcccg ggtacccgtg       9180

tatccaataa accctcttgc agttgcatcc gacttgtggt ctcgctgttc cttgggaggg       9240

tctcctctga gtgattgact acccgtcagc gggggtcttt cattgttact taaagttaca       9300

ttggcttcct tgaaataaac atggagtatt cagaatgtgt cataaatatt tctaatttta       9360

agatagtatc tccattggct ttctactttt tcttttattt ttttttgtcc tctgtcttcc       9420

atttgttgtt gttgttgttt gtttgtttgt ttgttggttg gttggttaat ttttttttaa       9480

agatcctaca ctatagttca agctagacta ttagctactc tgtaacccag ggtgaccttg       9540

aagtcatggg tagcctgctg ttttagcctt cccacatcta agattacagg tatgagctat       9600

catttttggt atattgattg attgattgat tgatgtgtgt gtgtgtgatt gtgtttgtgt       9660

gtgtgactgt gaaaatgtgt gtatgggtgt gtgtgaatgt gtgtatgtat gtgtgtgtgt       9720

gagtgtgtgt gtgtgtgtgt gcatgtgtgt gtgtgtgact gtgtctatgt gtatgactgt       9780

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgttgtgaa aaaatattct       9840

atggtagtga gagccaacgc tccggctcag gtgtcaggtt ggtttttgag acagagtctt       9900

tcacttagct tgg                                                          9913
