                               SEQUENCE LISTING

<110> METAGENOMI IP TECHNOLOGIES, LLC
 
<120> SYSTEMS AND METHODS FOR TRANSPOSING CARGO NUCLEOTIDE SEQUENCES

<130> 55921-714.602

<140>
<141>

<150> 63/232,578
<151> 2021-08-12

<150> 63/187,290
<151> 2021-05-11

<150> 63/082,983
<151> 2020-09-24

<160> 108   

<170> PatentIn version 3.5

<210> 1
<211> 612
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 active effector sequence

<220>
<223> MG64-1 active effector

<400> 1
Met Ser Gln Ile Thr Ile Gln Cys Arg Leu Val Ala Lys Glu Pro Ile 
1               5                   10                  15      


Arg His Thr Leu Trp Gln Leu Met Ala Asp Leu Asn Thr Pro Phe Ile 
            20                  25                  30          


Asn Glu Leu Leu Gln Lys Val Ala Gln His Pro Asp Phe Glu Lys Trp 
        35                  40                  45              


Lys Gln Arg Gly Arg Leu Lys Val Lys Val Ile Glu Gln Leu Gly Asn 
    50                  55                  60                  


Glu Leu Lys Lys Asp Pro Arg Phe Leu Gly Gln Pro Ala Arg Phe Tyr 
65                  70                  75                  80  


Thr Ser Gly Ile Asn Leu Val Lys Tyr Ile Phe Lys Ser Trp Leu Lys 
                85                  90                  95      


Leu Gln Gln Arg Leu Gln Gln Lys Leu Asp Arg Lys Arg Arg Trp Leu 
            100                 105                 110         


Glu Val Leu Lys Ser Asp Asp Gln Leu Ile Lys Asp Gly Gln Thr Asp 
        115                 120                 125             


Leu Glu Thr Ile Arg Gln Lys Ala Thr Glu Ile Leu Gln Ser Tyr Glu 
    130                 135                 140                 


Gly Thr Glu Gln Leu Phe Asn Thr Leu Phe Gln Ala Tyr Asn Ser Glu 
145                 150                 155                 160 


Glu Asp Ile Leu Thr Arg Thr Ala Leu Asn Tyr Leu Leu Lys Asn Arg 
                165                 170                 175     


Cys Lys Leu Pro Gln Lys Pro Glu Asp Ala Lys Lys Phe Ala Lys Arg 
            180                 185                 190         


Arg Arg Gln Val Glu Ile Ala Ile Lys Arg Leu Gln Glu Gln Ile Lys 
        195                 200                 205             


Ala Arg Leu Pro Gln Gly Arg Asp Val Thr Asn Glu Asn Trp Leu Glu 
    210                 215                 220                 


Thr Leu Asn Leu Ala Cys Tyr Thr Asp Pro Glu Asn Ile Glu Glu Ala 
225                 230                 235                 240 


Arg Ser Trp Gln Asp Lys Leu Leu Thr Lys Ser Ser Ser Ile Pro Phe 
                245                 250                 255     


Pro Ile Asn Tyr Glu Thr Asn Glu Asp Leu Ile Trp Ser Lys Asn Glu 
            260                 265                 270         


Lys Gly His Leu Cys Val Gln Phe Asn Gly Ile Ser Asp Leu Lys Phe 
        275                 280                 285             


Lys Ile Tyr Cys Asp Lys Arg Gln Leu Lys Trp Phe Gln Arg Phe Tyr 
    290                 295                 300                 


Glu Asp Gln Gln Ile Lys Lys Ser Asn Asn Asn Gln His Ser Ser Ala 
305                 310                 315                 320 


Leu Phe Thr Leu Arg Ser Gly Arg Ile Leu Trp Gln Glu Asp Lys Gly 
                325                 330                 335     


Lys Gly Gln Leu Trp Asp Ile His Arg Leu Thr Leu Gln Cys Thr Leu 
            340                 345                 350         


Asp Thr Arg Thr Trp Thr Gln Glu Gly Thr Glu Gln Val Lys Glu Glu 
        355                 360                 365             


Lys Ala Asp Glu Ile Ala Gly Ile Leu Thr Arg Met Asn Glu Lys Gly 
    370                 375                 380                 


Asp Leu Thr Lys Asn Gln Gln Ala Phe Ile Gln Arg Lys Gln Ser Thr 
385                 390                 395                 400 


Leu Asp Lys Leu Glu Asn Pro Phe Pro Arg Pro Ser Arg Pro Val Tyr 
                405                 410                 415     


Arg Gly Gln Ser Asn Ile Leu Leu Gly Val Ser Met Glu Leu Lys Lys 
            420                 425                 430         


Pro Ala Thr Ile Ala Val Ile Asp Gly Met Thr Arg Lys Val Leu Thr 
        435                 440                 445             


Tyr Arg Asn Ile Lys Gln Leu Leu Gly Lys Asn Tyr Pro Leu Leu Asn 
    450                 455                 460                 


Arg Gln Arg Arg Gln Lys Gln Leu Gln Ser His Gln Arg Asn Val Ala 
465                 470                 475                 480 


Gln Arg Lys Glu Ala Phe Asn Gln Phe Gly Asp Ser Glu Leu Gly Glu 
                485                 490                 495     


Tyr Ile Asp Arg Leu Leu Ala Lys Ala Ile Ile Ala Ile Ala Lys Gln 
            500                 505                 510         


Tyr Gln Ala Arg Ser Ile Val Val Pro His Leu Lys Asp Ile Arg Glu 
        515                 520                 525             


Ala Ile Gln Ser Glu Ile Gln Ala Leu Ala Glu Ala Lys Ile Pro Asn 
    530                 535                 540                 


Cys Ile Glu Ala Gln Ala Glu Tyr Ala Lys Lys Tyr Arg Ile Gln Val 
545                 550                 555                 560 


His Gln Trp Ser Tyr Gly Arg Leu Ile Asp Asn Ile Gln Ala Gln Ala 
                565                 570                 575     


Ser Lys Leu Gly Ile Val Ile Glu Glu Ser Gln Gln Pro Leu Gln Gly 
            580                 585                 590         


Thr Pro Leu Gln Lys Ala Ala Glu Leu Ala Phe Lys Ala Tyr Gln Ser 
        595                 600                 605             


Arg Leu Ser Ala 
    610         


<210> 2
<211> 563
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 active transposition protein sequence

<220>
<223> MG64-1-B active transposition protein

<400> 2
Met Lys Asn Ala Asn Ser Pro Pro Ser Ser Ser Val Asp Asp His Gln 
1               5                   10                  15      


Lys Glu Gln His Leu Val Ile Pro Ser Glu Leu Ser Asp Glu Ala Gln 
            20                  25                  30          


Leu Lys Leu Glu Val Ile Gln Thr Leu Leu Glu Pro Cys Asp Arg Arg 
        35                  40                  45              


Thr Tyr Gly Gln Arg Leu Arg Glu Ala Ala Glu Lys Leu Gly Lys Ser 
    50                  55                  60                  


Lys Arg Thr Val Gln Arg Leu Val Lys Lys Trp Glu Glu Glu Gly Leu 
65                  70                  75                  80  


Glu Ala Ile Ala Pro Thr Asn Arg Ser Asp Lys Gly Asp Phe Arg Ile 
                85                  90                  95      


Glu Glu Gln Leu Gln Glu Phe Ile Ile Lys Thr Tyr Gln Asn Gly Asn 
            100                 105                 110         


Lys Gly Ser Leu Arg Val Thr Arg Lys Gln Val Tyr Leu Lys Thr Lys 
        115                 120                 125             


Ala Lys Ala Glu Glu Leu Ser Ile Asn Pro Pro Ser His Met Thr Val 
    130                 135                 140                 


Tyr Arg Ile Leu Gln Pro Leu Ile Glu Lys Gln Glu Lys Lys Lys Ser 
145                 150                 155                 160 


Ile Arg Ser Pro Gly Trp Arg Gly Ser Gln Leu Ser Val Lys Thr Arg 
                165                 170                 175     


Ala Gly Gln Asp Leu Ser Val Glu Tyr Ser Asn His Val Trp Gln Cys 
            180                 185                 190         


Asp His Thr Arg Ala Asp Leu Leu Leu Val Asp Gln Tyr Gly Glu Leu 
        195                 200                 205             


Leu Gly Arg Pro Trp Leu Thr Thr Val Ile Asp Thr Tyr Ser Arg Cys 
    210                 215                 220                 


Ile Ile Gly Ile Asn Leu Gly Phe Asp Ala Pro Ser Ser Gln Val Val 
225                 230                 235                 240 


Ala Leu Ala Leu Arg His Ala Ile Leu Pro Lys Tyr Tyr Thr Pro Asp 
                245                 250                 255     


Tyr Leu Leu Gly Glu Glu Trp Gly Thr Tyr Gly Lys Pro Glu His Phe 
            260                 265                 270         


Tyr Thr Asp Gly Gly Lys Asp Phe Arg Ser Asn His Leu Gln Gln Ile 
        275                 280                 285             


Ser Val Gln Leu Gly Phe Val Cys His Leu Arg Asp Arg Pro Ser Glu 
    290                 295                 300                 


Gly Gly Ile Val Glu Arg Pro Phe Lys Thr Leu Asn Leu Glu Phe Phe 
305                 310                 315                 320 


Ser Thr Leu Pro Gly Tyr Thr Gly Ser Asn Val Gln Glu Arg Pro Glu 
                325                 330                 335     


Asp Ala Glu Lys Glu Ala Cys Leu Thr Leu Arg Gln Leu Glu Gln Lys 
            340                 345                 350         


Leu Val Arg Tyr Ile Val Asp Asn Tyr Asn Gln Arg Met Asp Ala Arg 
        355                 360                 365             


Met Gly Asp Gln Thr Arg Phe Gln Arg Trp Glu Ser Gly Leu Ile Ala 
    370                 375                 380                 


Thr Pro Asp Val Ile Ser Glu Arg Glu Leu Asp Ile Cys Leu Met Lys 
385                 390                 395                 400 


Gln Thr Arg Arg Lys Val Gln Arg Gly Gly Tyr Leu Gln Phe Glu Asn 
                405                 410                 415     


Leu Met Tyr Arg Gly Glu Asn Leu Ala Gly Tyr Ala Gly Glu Ser Val 
            420                 425                 430         


Ile Leu Arg Phe Asp Pro Arg Asp Ile Thr Thr Val Leu Val Tyr Gln 
        435                 440                 445             


Lys Glu Ser Asn His Glu Val Phe Leu Thr Arg Ala Tyr Ala Met Asp 
    450                 455                 460                 


Leu Glu Thr Glu Gln Met Ser Leu Asp Glu Ala Lys Ala Ser Ser Lys 
465                 470                 475                 480 


Arg Val Arg Asp Ala Gly Lys Thr Val Gly Asn Arg Ser Ile Leu Ser 
                485                 490                 495     


Glu Val Arg Asp Arg Gln Ile Phe Pro Lys Ala Lys Lys Ser Lys Lys 
            500                 505                 510         


Glu Arg Tyr Gln Glu Glu Gln Lys Ala Ile Thr Ser Lys Pro Leu Glu 
        515                 520                 525             


Ile Thr Glu Trp Glu Ser Glu Glu Thr Asp Phe Ser Pro Pro Ser Ser 
    530                 535                 540                 


Glu Thr Pro Gln Val Glu Val Phe Asp Tyr Glu Thr Leu Gln Glu Asp 
545                 550                 555                 560 


Tyr Gly Phe 
            


<210> 3
<211> 278
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 active transposition protein sequence

<220>
<223> MG64-1-C active transposition protein

<400> 3
Met Thr Ile Gln Glu Ala Gln Ala Val Ala Lys Gln Leu Gly Asp Ile 
1               5                   10                  15      


Gln Leu Thr Ser Glu Lys Leu Gln Ala Glu Ile Gln Arg Leu Asn Arg 
            20                  25                  30          


Lys Thr Val Val Thr Leu Ser His Val Glu Ala Leu His Asn Trp Leu 
        35                  40                  45              


Glu Gly Lys Arg Gln Ala Lys Gln Ser Cys Arg Val Val Gly Glu Ser 
    50                  55                  60                  


Arg Thr Gly Lys Thr Ile Ala Cys Asn Ala Tyr Arg Leu Arg His Lys 
65                  70                  75                  80  


Pro Ile Gln Thr Pro Gly Lys Pro Pro Ile Val Pro Val Val Tyr Ile 
                85                  90                  95      


Gln Val Thr Gln Glu Cys Gly Ala Lys Asp Leu Phe Gly Ala Ile Ile 
            100                 105                 110         


Glu His Leu Lys Tyr Gln Met Thr Lys Gly Thr Val Ala Glu Ile Arg 
        115                 120                 125             


Gln Arg Thr Phe Lys Val Leu Gln Arg Cys Gly Val Glu Met Leu Ile 
    130                 135                 140                 


Ile Asp Glu Ala Asp Arg Leu Lys Pro Lys Thr Phe Ala Glu Val Arg 
145                 150                 155                 160 


Asp Ile Phe Asp Lys Leu Asn Ile Ala Val Val Leu Val Gly Thr Asp 
                165                 170                 175     


Arg Leu Asp Ala Val Ile Lys Arg Asp Glu Gln Val Tyr Asn Arg Phe 
            180                 185                 190         


Arg Ala Cys His Arg Phe Gly Lys Leu Ala Gly Asp Glu Phe Ser Gln 
        195                 200                 205             


Thr Val Asn Ile Trp Glu Arg Gln Val Leu Lys Leu Pro Val Ala Ser 
    210                 215                 220                 


Asn Leu Ser Ser Lys Arg Met Leu Lys Ile Leu Gly Gln Ala Thr Gly 
225                 230                 235                 240 


Gly Tyr Leu Gly Leu Leu Asp Met Ile Leu Arg Glu Ser Ala Ile Arg 
                245                 250                 255     


Ala Leu Lys Lys Gly Leu Gln Lys Ile Asp Leu Asp Thr Leu Lys Glu 
            260                 265                 270         


Val Thr Glu Glu Tyr Arg 
        275             


<210> 4
<211> 171
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 active transposition protein sequence

<220>
<223> MG64-1-Q active transposition protein

<400> 4
Met Glu Ser Arg Glu Ile Gln Pro Trp Trp Phe Leu Val Glu Pro Leu 
1               5                   10                  15      


Ala Gly Glu Ser Ile Ser His Phe Leu Gly Arg Phe Arg Arg Glu Asn 
            20                  25                  30          


Glu Leu Thr Val Thr Met Met Gly Lys Ile Thr Gly Leu Gly Gly Thr 
        35                  40                  45              


Ile Thr Arg Trp Glu Lys Phe Arg Phe Ile Pro Ile Pro Thr Glu Glu 
    50                  55                  60                  


Glu Leu Thr Ala Leu Ser Glu Val Val Gln Val Glu Val Glu Arg Leu 
65                  70                  75                  80  


Trp Gln Met Phe Pro Pro Lys Gly Val Gly Met Lys His Gln Pro Ile 
                85                  90                  95      


Arg Leu Cys Gly Ala Cys Tyr Glu Glu Glu Arg Cys His Lys Ile Glu 
            100                 105                 110         


Trp Gln Leu Lys Thr Thr Gln Phe Cys Ser Gln His Gly Leu Thr Leu 
        115                 120                 125             


Leu Ser Glu Cys Pro Asn Cys Gly Ala Arg Phe Gln Phe Pro Ala Leu 
    130                 135                 140                 


Trp Val Asn Gly Trp Cys His Arg Cys Phe Leu Thr Phe Gly Glu Met 
145                 150                 155                 160 


Val Glu Gly Gln Ser Asn Lys Lys Lys Tyr Leu 
                165                 170     


<210> 5
<211> 319
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector tested sgRNA sequence


<220>
<221> modified_base
<222> (296)..(319)
<223> a, c, t, g, unknown or other

<400> 5
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta caatttaggt tgtagagatg attaacctgt aacttgaggt tagctaataa      180

tttcatttta tagggtaggt gcgctcccag caataagtgg cgtgggttta ccacagtgac      240

ggctactgaa tcacctccga ccaaggagga atccactgaa aagatggatt gaaagnnnnn      300

nnnnnnnnnn nnnnnnnnn                                                   319


<210> 6
<211> 277
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector tracrRNA sequence

<400> 6
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta caatttaggt tgtagagatg attaacctgt aacttgaggt tagctaataa      180

tttcatttta tagggtaggt gcgctcccag caataagtgg cgtgggttta ccacagtgac      240

ggctactgaa tcacctccga ccaaggagga atccact                               277


<210> 7
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-1 active effector's target CRISPR repeat

<400> 7
cgtcacaatc tattttggtt aatgagatgg attgaaag                               38


<210> 8
<211> 449
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active transposon end RE

<400> 8
aatgaacaaa aatgtctgat tattacataa ttgtttattt aatataattg tatcgtaata       60

cttgaagttt ggagacaagt aatttgttaa tactgctcca gtccctaaaa aagtgccatt      120

cgggtaaatg acacttaatc tgttaattta ctggaaaatg acagttaatt tgttaatata      180

gtaagcaata acttttgtca aagattaatg ctataattca gctaaagcag tgattatata      240

aagctttcac tctcaaatag ttcggcgaca cgattttgtt aagacgacaa ataattagtt      300

actgtacatt tacccataac tttgccgttt tggtaaggtt atcgttcaaa acacaagtgg      360

caagattatg gttcaaaacc taagtcccgt ttagtttgct tgaacacttc acgaacttga      420

gggtaacgaa gaaagctagg gtgagtcaa                                        449


<210> 9
<211> 319
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active transposon end LE

<400> 9
ctcttaagga aatctatgta agtttgttgg gttagttgcg ttttcagtaa atactgtgtt       60

atagtaagaa cttgtgcgga cgtatagctc agttggttag agtacatcgt tgacatcgat      120

ggggtcactg gttcgagtcc agttacgtcc atattttttt gaagtgtgta taatattaac      180

tatgtgactt tatgtacatt aacagattat ttgtcatcgg taacaaattg ttgtcatctt      240

aacaaaatat ttgtcatcaa taacatatta tgtgtcgtgt gcttattact gaaactaatc      300

ctagacgatg gtaaaaaat                                                   319


<210> 10
<211> 308
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active transposon outer bounds of RE

<400> 10
tgtacagtaa ctaattattt gtcgtcttaa caaaatcgtg tcgccgaact atttgagagt       60

gaaagcttta tataatcact gctttagctg aattatagca ttaatctttg acaaaagtta      120

ttgcttacta tattaacaaa ttaactgtca ttttccagta aattaacaga ttaagtgtca      180

tttacccgaa tggcactttt ttagggactg gagcagtatt aacaaattac ttgtctccaa      240

acttcaagta ttacgataca attatattaa ataaacaatt atgtaataat cagacatttt      300

tgttcatt                                                               308


<210> 11
<211> 127
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active transposon minimal LE

<400> 11
tgtacattaa cagattattt gtcatcggta acaaattgtt gtcatcttaa caaaatattt       60

gtcatcaata acatattatg tgtcgtgtgc ttattactga aactaatcct agacgatggt      120

aaaaaat                                                                127


<210> 12
<211> 643
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-3 effector

<400> 12
Met Ser Lys Ile Thr Ile Gln Cys Arg Leu Val Ala Ser Glu Ala Thr 
1               5                   10                  15      


Arg Gln Tyr Leu Trp His Leu Met Ala Asp Ile Tyr Thr Pro Phe Val 
            20                  25                  30          


Asn Glu Met Leu Arg Gln Ile Arg Glu Asp Asp Asn Phe Glu Gln Trp 
        35                  40                  45              


Arg Gln Ala Gly Lys Ile Pro Ala Gly Val Phe Glu Asp Tyr Arg Lys 
    50                  55                  60                  


Ala Leu Lys Thr Glu Ser Arg Phe Gln Gly Met Pro Gly Arg Trp Tyr 
65                  70                  75                  80  


Tyr Ala Gly Arg Glu Glu Val Lys Arg Ile Tyr Lys Ser Trp Leu Ala 
                85                  90                  95      


Leu Arg Arg Arg Leu Arg Asn Gln Leu Ser Gly Gln Asn Arg Trp Leu 
            100                 105                 110         


Glu Val Leu Gln Ser Asp Glu Thr Leu Met Ala Val Ser Gly Leu Asp 
        115                 120                 125             


Leu Pro Ala Leu Arg Ala Ala Ser Thr Lys Leu Leu Asp Leu Leu Ser 
    130                 135                 140                 


Ser Gln Ile Ala Lys Pro Ala Lys Gly Ser Lys Lys Thr Asn Arg Gly 
145                 150                 155                 160 


Lys Gly Lys Lys Gln Ala Lys Gln Thr Gln Gly Lys Ser Leu Tyr Gln 
                165                 170                 175     


Ser Leu Trp Asp Leu Tyr Lys Glu Thr Glu Asp Ile Leu Gln Lys Cys 
            180                 185                 190         


Ala Ile Ala Tyr Leu Leu Lys Asn Lys Ser Gln Val Pro Asp Lys Pro 
        195                 200                 205             


Glu Asp Pro Glu Lys Phe Arg His Arg Arg Arg Lys Ala Glu Ile Arg 
    210                 215                 220                 


Thr Glu Arg Leu Asn Glu Gln Leu Thr Lys Thr Arg Leu Pro Lys Gly 
225                 230                 235                 240 


Arg Asp Leu Thr Asn Glu Gln Trp Leu Glu Ala Leu Ala Ile Ala Thr 
                245                 250                 255     


Glu Gln Ile Pro Lys Asp Glu Thr Glu Ala Ala Ile Trp Gln Ser Arg 
            260                 265                 270         


Leu Leu Thr Asp Ala Ala Ser Leu Pro Phe Pro Val Ala Tyr Glu Thr 
        275                 280                 285             


Asn Glu Asp Leu Lys Trp Phe Leu Asn Gly Lys Gly Arg Leu Cys Val 
    290                 295                 300                 


Ser Phe Asn Gly Leu Ser Glu His Thr Phe Glu Ile Tyr Cys Asp Lys 
305                 310                 315                 320 


Arg Gln Leu His Trp Phe Lys Arg Phe Leu Glu Asp Gln Gln Ile Lys 
                325                 330                 335     


Lys Glu His Gln Gly Lys Arg Ser Ser Gly Leu Phe Thr Leu Arg Ser 
            340                 345                 350         


Gly Arg Ile Ser Trp Thr Ser Pro Ser Asp Ile Asp Lys Ser Pro Cys 
        355                 360                 365             


Trp Thr Ala Asn Arg Leu Thr Leu His Cys Ser Val Asp Thr Arg Leu 
    370                 375                 380                 


Trp Thr Gln Glu Gly Thr Glu Glu Val Arg Gln Glu Lys Ala Thr Asn 
385                 390                 395                 400 


Ile Ala Lys Ile Ile Ala Gly Thr Lys Ala Lys Gly Asn Leu Asn Gln 
                405                 410                 415     


Lys Gln Gln Asp Phe Ile Thr Lys Arg Glu Thr Thr Leu Lys Leu Leu 
            420                 425                 430         


His Asn Pro Phe Pro Arg Pro Ser Lys Pro Leu Tyr Gln Gly Asn Pro 
        435                 440                 445             


Ser Ile Ile Ala Ala Val Ser Phe Gly Leu Glu Lys Pro Ala Thr Leu 
    450                 455                 460                 


Ala Ile Val Asp Ile Thr Thr Gly Lys Ala Ile Thr Tyr Arg Ser Ile 
465                 470                 475                 480 


Arg Gln Leu Leu Asp Gln Asn Tyr Lys Leu Phe Thr Lys His Arg Leu 
                485                 490                 495     


Gln Gln Gln Gln Arg Ala His Gln Arg His Gln Asn Gln Lys Glu Ser 
            500                 505                 510         


Ala Glu Asn Arg Ile Ser Glu Gly Gly Leu Gly Glu His Val Asp Ser 
        515                 520                 525             


Leu Ile Ala Lys Ala Ile Leu Glu Thr Ala Ala Glu Tyr Gly Ala Ser 
    530                 535                 540                 


Ser Ile Val Leu Pro Glu Leu Gly Asn Ile Arg Glu Ile Ile Gln Ala 
545                 550                 555                 560 


Glu Val Ile Ala Lys Ala Glu Arg Lys Ile Pro Gly Leu Lys Glu Lys 
                565                 570                 575     


Gln Asp Glu Tyr Ala Ala Lys Phe Arg Ala Ser Val His Arg Trp Ser 
            580                 585                 590         


Tyr Gly Arg Leu Ala Gln Lys Ile Thr Thr Lys Ala Ala Leu Gln Gly 
        595                 600                 605             


Leu Glu Thr Glu Ser Thr Arg Gln Pro Leu Gln Gly Ser Pro Gln Glu 
    610                 615                 620                 


Lys Ala Arg Asn Leu Ala Ile Ala Ala Tyr Glu Ser Arg Lys Val Asp 
625                 630                 635                 640 


Gln Arg Ala 
            


<210> 13
<211> 542
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-3-B transposition protein

<400> 13
Met Glu Leu Val Asn Pro Asp Asp Leu Asn Ser Val Glu Ala Arg Leu 
1               5                   10                  15      


Lys Leu Glu Ile Val Glu Lys Leu Ser Glu Pro Cys Asp Arg Arg Thr 
            20                  25                  30          


Tyr Gly Glu Arg Leu Arg Ser Ala Ala Gln Lys Leu Glu Cys Ser Val 
        35                  40                  45              


Arg Thr Val Gln Arg Leu Met Lys Lys Trp Glu Gln Glu Gly Ile His 
    50                  55                  60                  


Ala Leu Ile Asp Ser Gly Arg Lys Asp Lys Gly Asn Pro Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Trp Gln Ser Phe Ile Lys Asp Ala Tyr Asp Asn Gly Lys Cys 
                85                  90                  95      


Thr Pro Ala Gln Val Phe Thr Lys Val Arg Gln Arg Ala Arg Gln Glu 
            100                 105                 110         


Gly Leu Asp Ser His Pro Ser His Met Thr Val Tyr Arg Ile Leu Asn 
        115                 120                 125             


Pro Leu Ile Glu Ala Lys Glu Gln Lys Asn Asn Ile Arg Asn Val Gly 
    130                 135                 140                 


Trp Lys Gly Ala Arg Leu Ala Leu Lys Thr Arg Asp Gly Glu Val Leu 
145                 150                 155                 160 


Glu Ile Asp Tyr Ser Asn Gln Val Trp Gln Cys Asp His Thr Arg Ala 
                165                 170                 175     


Asp Ile Leu Leu Val Asp Lys Tyr Gly Tyr Gln Met Gly Arg Pro Trp 
            180                 185                 190         


Leu Thr Thr Val Val Asp Thr Tyr Ser Arg Ala Ile Val Gly Ile Asn 
        195                 200                 205             


Leu Gly Tyr Asp Ala Pro Ser Ser Arg Val Val Ala Leu Ala Leu Arg 
    210                 215                 220                 


His Ala Ile Leu Pro Lys Gln Tyr Gly Ala Glu Tyr Lys Leu Tyr Ala 
225                 230                 235                 240 


Glu Trp Pro Thr Cys Gly Val Pro Asp His Met Phe Thr Asp Gly Gly 
                245                 250                 255     


Lys Asp Phe Arg Ser Asn His Leu Gln Gln Ile Gly Val Gln Leu Gly 
            260                 265                 270         


Phe Ile Cys His Leu Arg Asp Arg Pro Ser Glu Gly Gly Ile Val Glu 
        275                 280                 285             


Arg Pro Phe Gly Thr Ile Asn Thr Gln Phe Phe Ser Thr Leu Pro Gly 
    290                 295                 300                 


Tyr Thr Gly Ser Asn Val Gln Asp Arg Pro Pro Glu Ala Glu Ala Glu 
305                 310                 315                 320 


Ala Cys Leu Thr Leu His Glu Leu Glu Lys Leu Leu Val Ala Tyr Ile 
                325                 330                 335     


Val Asn Thr Tyr Asn Gln Arg Leu Asp Ala Arg Met Gly Asp Gln Thr 
            340                 345                 350         


Arg Ile Gln Arg Trp Glu Ala Gly Leu Leu Lys Gln Pro Pro Thr Ile 
        355                 360                 365             


Ser Glu Arg Glu Leu Asp Ile Cys Leu Met Lys Gln Thr Arg Arg Thr 
    370                 375                 380                 


Ile Tyr Arg Gly Gly Tyr Leu Gln Phe Glu Asn Leu Thr Tyr Trp Gly 
385                 390                 395                 400 


Glu Thr Leu Ala Glu Gln Ala Gly Glu Asn Ile Val Leu Arg Tyr Asp 
                405                 410                 415     


Pro Arg Asp Ile Thr Arg Leu Leu Val Tyr Arg Tyr Glu Ser Asp Arg 
            420                 425                 430         


Glu Val Tyr Leu Gly Val Ala Gln Ala Gln Asp Leu Glu Gly Glu Val 
        435                 440                 445             


Leu Ala Leu Asp Asp Ala Lys Ala His Ser Arg Arg Ile Arg Glu Asp 
    450                 455                 460                 


Gly Lys Ala Val Ser Asn Asp Ala Met Leu Asp Glu Met Arg Asp Arg 
465                 470                 475                 480 


Glu Ala Phe Val Asp Glu Lys Lys Lys Ser Arg Lys Glu Arg Gln Lys 
                485                 490                 495     


Glu Glu Gln Glu Asp Leu Arg Gln Thr Pro Leu Pro Val Ile Glu Ala 
            500                 505                 510         


Asp Ser Phe Asp Glu Asp Glu Ser Gly Glu Pro Gln Asp Asn Leu Glu 
        515                 520                 525             


Ile Pro Glu Phe Glu Ile Trp Glu Phe Asp Asn Asn Asp Ile 
    530                 535                 540         


<210> 14
<211> 272
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-3-C transposition protein

<400> 14
Met Val Thr Thr Thr Leu Ser Glu Gln Glu Ile Gln Ala His Ile Glu 
1               5                   10                  15      


Arg Leu Arg Lys Asp Lys Thr Val Ala Leu Glu Ser Val Gln Gln Ala 
            20                  25                  30          


His Thr Trp Leu Asp Arg Lys Arg Asn Ala Arg Gln Cys Gly Arg Ile 
        35                  40                  45              


Ile Gly Glu Ser Arg Thr Gly Lys Thr Lys Ala Cys Glu Ser Tyr Leu 
    50                  55                  60                  


Lys Lys Asn Gly Leu Pro Asp Leu Ser Gly Lys Ile Pro Asn Ile Pro 
65                  70                  75                  80  


Ile Ser Tyr Phe Val Pro Lys Gln Asp Cys Thr Ser Arg Glu Leu Phe 
                85                  90                  95      


Arg Ala Ile Leu Glu His Tyr Gly Asp Glu Leu Pro Arg Gly Thr Val 
            100                 105                 110         


Gly Asp Ala Arg Ser Lys Thr Phe Lys Val Leu Arg Glu Cys Gln Thr 
        115                 120                 125             


Glu Met Leu Ile Ile Asp Glu Ala Asp Arg Leu Lys Pro Lys Thr Phe 
    130                 135                 140                 


Ala Asp Val Arg Asp Ile Phe Asp Asn Leu Glu Ile Ser Val Val Leu 
145                 150                 155                 160 


Val Gly Thr Lys Lys Arg Leu Asp Lys Val Val Lys Ala Asp Glu Gln 
                165                 170                 175     


Val Phe Asn Arg Phe Arg Ser Ser Tyr Lys Ile Gly Thr Ile Pro Ser 
            180                 185                 190         


Ser Gln Leu Ala Thr Ile Val Gly Val Trp Glu Arg Asp Ile Leu Lys 
        195                 200                 205             


Leu Pro Leu Pro Ser Asn Leu Thr Ser Glu Ser Met Leu Lys Glu Ile 
    210                 215                 220                 


Arg Arg Ala Thr Gly Lys Ser Arg Lys Gly Tyr Tyr Ile Gly Leu Ile 
225                 230                 235                 240 


Asp Met Val Leu Arg Ala Ala Ala Val Met Ala Leu Glu Lys Gly Gln 
                245                 250                 255     


Met Lys Val Asp Lys Ala Thr Leu Lys Val Ala Val Glu Asp Tyr Leu 
            260                 265                 270         


<210> 15
<211> 165
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-3-Q transposition protein

<400> 15
Met Thr Met Pro Ile Val Pro Thr Trp Val Phe Pro Val Asp Pro Tyr 
1               5                   10                  15      


Ser Gly Glu Ser Leu Ser His Phe Leu Gly Arg Phe Cys Arg Glu Asn 
            20                  25                  30          


His Ala Thr Leu Asn Gln Leu Gly Glu Lys Thr Gly Leu Gly Ala Val 
        35                  40                  45              


Leu Gly Arg Trp Glu Lys Phe Arg Phe Ile Pro Pro Pro Asn Asp Ala 
    50                  55                  60                  


Gln Leu Ala Ala Leu Ala Lys Leu Val Arg Leu Glu Val Asp Gln Ile 
65                  70                  75                  80  


Lys Gln Met Leu Pro Gln Glu Ala Met Gln Asn Arg Val Ile Arg Leu 
                85                  90                  95      


Cys Ala Ala Cys Tyr Ala Glu Glu Pro Tyr His Arg Ile Glu Trp Gln 
            100                 105                 110         


Tyr Lys Leu Ala Asn Arg Cys Asp Arg His His Leu Leu Leu Leu Leu 
        115                 120                 125             


Glu Cys Pro Asn Cys Lys Ala Lys Leu Pro Met Pro Ser Lys Trp Ala 
    130                 135                 140                 


Asn Gly Thr Cys Lys Arg Cys Leu Thr Pro Phe Asp Gln Met Val Ala 
145                 150                 155                 160 


Leu Gln Lys Gly Val 
                165 


<210> 16
<211> 692
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-5 effector

<400> 16
Met Lys Thr Ile Arg Cys Cys Leu Cys Ala Asn Pro Glu Thr Arg Arg 
1               5                   10                  15      


Tyr Phe Trp Lys Ile Met Val Thr Tyr Thr Leu Leu Val Asn Glu Leu 
            20                  25                  30          


Leu Ala Ala Met Pro Gln Arg Pro Glu Phe Ala Gln Trp Lys Gln Arg 
        35                  40                  45              


Gly Thr Ile Ala Arg Glu Ala Val Arg Ile Val Leu Thr Pro Leu Lys 
    50                  55                  60                  


Thr Asp Pro Thr Tyr Ala Asp Leu Pro Lys Arg Phe Phe Ser Ser Ala 
65                  70                  75                  80  


Glu Leu Leu Val Cys Tyr Val Tyr Lys Ser Trp Leu Ala Leu Gln Lys 
                85                  90                  95      


Arg Arg Tyr Trp Lys Leu Val Gly Lys Gln Arg Trp Leu Gln Val Ile 
            100                 105                 110         


Glu Asp Asp Leu Gln Ser Leu Leu Thr Asp Asn Phe Ser Leu Glu Ser 
        115                 120                 125             


Val Gln Ser Lys Ala His Gln Ile Leu Glu Gln Ala His Lys Glu Leu 
    130                 135                 140                 


Glu Lys Gln Pro Gln Arg Phe Lys Lys Lys Gly Lys Lys Ser Arg Pro 
145                 150                 155                 160 


Leu Phe Gly Tyr Leu Leu Asp Leu Tyr Gly Thr Thr Ala Asp Lys Leu 
                165                 170                 175     


Glu Arg Arg Ala Ile Gly His Leu Leu His His Asp Leu Lys Val Ser 
            180                 185                 190         


Asp Thr Glu Asp Phe Pro Glu Thr Ile Gln Phe Ser Ile Asp Gln Gln 
        195                 200                 205             


Gln Val Glu Ile Ala Arg Leu Lys Glu Gln Leu Gln Ser Arg Leu Pro 
    210                 215                 220                 


Asp Gly Arg Asp Pro Thr Gln Ala Arg Phe Leu Glu Lys Leu Arg Ile 
225                 230                 235                 240 


Ala Thr Ala Leu Pro Glu Leu Glu Leu Glu Gly Phe Asp Glu Glu His 
                245                 250                 255     


Phe Ser Glu Trp Arg Thr Gln Lys Gln Ile Pro Leu Leu Asn Pro Leu 
            260                 265                 270         


Pro Tyr Pro Val Leu Phe Gly Ser Ser Ser Asp Leu His Trp Lys Leu 
        275                 280                 285             


Glu Pro Gln Lys Ala Thr Thr Glu Ala Asn Ile Ser Pro Glu Val Pro 
    290                 295                 300                 


Thr Ala Arg Ser Glu Arg Val Lys Glu Arg Ile Gln Val Arg Phe Lys 
305                 310                 315                 320 


Gly Asp Glu Leu Gln Asp Ser Trp Phe Lys Leu Gln Cys Asp Arg Arg 
                325                 330                 335     


Gln Leu Pro Ile Phe Arg Gln Phe Val Thr Asp Tyr Leu Cys Gln Lys 
            340                 345                 350         


Gln Ala Pro Asp His Glu Lys Phe Gly Glu Gly Leu Phe Thr Leu Arg 
        355                 360                 365             


Ser Ala Cys Leu Val Trp Lys Glu Asp Pro Gln Gly Ala Arg Lys Arg 
    370                 375                 380                 


Lys Lys Arg Arg Lys Gln Gly Ala Cys Gln Asp Glu Pro Trp Glu Thr 
385                 390                 395                 400 


His Arg Leu Tyr Leu His Cys Thr Ile Asp Thr Arg Phe Leu Thr Gln 
                405                 410                 415     


Glu Gly Thr Glu Gln Val Arg Ala Thr Lys Leu Asp Leu Ala Gln Lys 
            420                 425                 430         


Ala Leu Glu Gly Ile Glu Asn Lys Thr Ala Leu Glu Thr Val Thr Gln 
        435                 440                 445             


Glu Pro Ser Ala Glu Gln Gln Lys His Leu Lys Arg Lys Gln Thr Thr 
    450                 455                 460                 


Val His Arg Leu Glu Thr Gln Lys Pro Pro Val Arg Pro Thr Ile Gln 
465                 470                 475                 480 


Pro Tyr Glu Gly Lys Ser Asn Ile Val Val Gly Val Ser Leu Ser Arg 
                485                 490                 495     


His Glu Pro Val Thr Leu Ile Val Phe Asp Thr Ala Gln Asn Lys Val 
            500                 505                 510         


Leu Glu Cys Met Gly Thr Gln Ala Leu Leu Lys Ile His Gly Ile Gln 
        515                 520                 525             


Ser Pro Arg Lys Asn Arg Ser Ile Gly Lys Leu Gln Gln Glu Gln Ser 
    530                 535                 540                 


Gln Leu Leu Arg Arg Trp Arg Arg Lys Arg Lys Gln Asn Pro His Arg 
545                 550                 555                 560 


Arg Ala Asp Gly Gln Arg Gln Asp Asn Tyr Arg Ser Gly Asn Ser Glu 
                565                 570                 575     


Ser Lys Leu Gly Asp Tyr Leu Asp Arg Leu Ile Ala Ala Arg Leu Val 
            580                 585                 590         


Ala Leu Ala Thr Lys Arg Gln Ala Ser Val Ile Val Leu Pro Glu Leu 
        595                 600                 605             


Gly Asp Ile Arg Glu Ser Val Glu Cys Ser Leu Gln Ala Lys Ala Gln 
    610                 615                 620                 


Arg Lys Tyr Pro Gln His Lys Lys Leu Gln Ala Lys Tyr Ala Lys His 
625                 630                 635                 640 


Phe Arg His Glu Phe His Arg Trp Ser Tyr Gly Arg Leu Gln Gln Tyr 
                645                 650                 655     


Ile Ala Glu Arg Ala Thr Gln Gln Asn Leu Ala Leu Leu Lys Gly Arg 
            660                 665                 670         


Gln Pro Lys Gln Gly Thr Glu Gln Glu Lys Val Leu Glu Ile Ile Ser 
        675                 680                 685             


Ser Ala Cys Leu 
    690         


<210> 17
<211> 636
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-5-B transposition protein

<400> 17
Met Thr Asn Ser Arg Leu Gly Gly Thr Met Lys Asn Leu Ser Asp His 
1               5                   10                  15      


Pro Asp Ser Glu Lys Leu Thr Tyr Glu Gln Glu His Cys Leu Val Asp 
            20                  25                  30          


Glu Leu Ser Pro Glu Leu Gln Arg Lys Val Glu Leu Ile Gln Ala Ile 
        35                  40                  45              


Val Asp Ala Pro Asp Arg Lys Thr Glu Arg Gln Arg Ile Ala Ile Ala 
    50                  55                  60                  


Ala Gln Glu Leu Gly Arg Cys Thr Lys Thr Ile Arg Ser Tyr Arg Asp 
65                  70                  75                  80  


Ala Leu Arg Glu Asp Gly Ile Val Ala Leu Thr Arg Thr Glu Arg Ser 
                85                  90                  95      


Asp Lys Gly Gln Arg Arg Asn Ile Ser Gln Pro Trp Ile Asp Leu Val 
            100                 105                 110         


Leu Ala Leu Tyr Lys Arg Gly Gln Arg Ser Phe Cys Arg Ser Arg Asn 
        115                 120                 125             


Gln Val Trp Leu Leu Ile Gln Gly Met Thr Ser Lys Leu Leu Ser Asp 
    130                 135                 140                 


Asp Trp Lys Thr Pro Glu Lys Arg Ala Glu Leu Met Glu Trp Tyr Ala 
145                 150                 155                 160 


Gln Lys Leu Gly Ala Ala Ala Glu Asn Ala Lys Ser Lys Leu Asn Lys 
                165                 170                 175     


Ile Leu Gly Ser Ile Arg Lys Glu Leu Glu Val Gly Ile Cys Met Pro 
            180                 185                 190         


Pro Arg Ser His Met Ser Val Tyr Gly Ile Ile Asp Asp Tyr Leu Glu 
        195                 200                 205             


Gln Gln His Arg Lys Ala Arg His Pro Gly Gln Gly Pro Glu Gln Val 
    210                 215                 220                 


Ile Gln Thr Thr Gly Glu Leu Leu Val Ile Glu Val Thr Asn Gly Ile 
225                 230                 235                 240 


Phe Gln Ala Asp His Ser Gly Ile Asp Ile Leu Leu Lys Asp Lys Asp 
                245                 250                 255     


Gly Asn Glu Ile Gly Tyr Pro Phe Leu Thr Val Ile Ile Glu Cys Ala 
            260                 265                 270         


Ser Gly Cys Val Thr Gly Phe Tyr Leu Gly Phe Arg Gln Pro Gly Ser 
        275                 280                 285             


His Glu Val Ala Leu Ala Leu Arg His Ala Ile Leu Pro Lys Gln Tyr 
    290                 295                 300                 


Gly Pro Glu Tyr Lys Leu Glu Lys Gln Trp Gln Cys Val Gly Ile Pro 
305                 310                 315                 320 


Arg Tyr Leu Val Thr Asp Arg Ala Lys Glu Phe Lys Ser Lys His Leu 
                325                 330                 335     


Gln Gln Ile Ala Ala Glu Leu Gly Phe Glu Leu Arg Tyr Arg Ala Tyr 
            340                 345                 350         


Pro Ser Gln Gly Gly Leu Val Glu Ser Val Phe Asp Lys Ile Asn Lys 
        355                 360                 365             


Glu Val Leu Ser Asn Leu Pro Gly Tyr Lys Gly Ser Asn Val Gln Lys 
    370                 375                 380                 


Arg Pro Lys Asn Ala Glu Lys Tyr Ala Cys Leu Thr Ile Glu Asp Leu 
385                 390                 395                 400 


Glu Gln Glu Leu Val Arg Tyr Phe Cys Asp His Tyr Asn Gln His Phe 
                405                 410                 415     


Tyr Pro Arg Met Lys Asp Arg Thr Arg Ala Met Gln Trp Glu Glu Arg 
            420                 425                 430         


Leu Val Glu Pro Pro Val Ile Pro Asp Glu Arg Glu Leu Asp Leu Cys 
        435                 440                 445             


Leu Leu Lys Arg Lys Gln Thr Ala Lys Val Gln Lys Tyr Gly Thr Ile 
    450                 455                 460                 


Gln Phe Gln Asn Glu Ile Tyr Gln Gly Asn Cys Leu Leu Gly Arg Glu 
465                 470                 475                 480 


Thr Glu Lys Ile Ser Phe Arg Tyr Asn Pro Ser Asn Ile Ile His Val 
                485                 490                 495     


Leu Ala Tyr Thr Val Glu Glu Thr Asp Lys Pro Ser Lys Phe Leu Gly 
            500                 505                 510         


Val Leu Lys Ala Arg Asp Arg Lys Glu Glu Lys Leu Ser Leu His Ser 
        515                 520                 525             


Leu Lys Leu Glu Gln Lys Leu Ile Arg Ala Arg Gly Lys Lys Leu Asp 
    530                 535                 540                 


Gln Ser Ser Ile Tyr Asn Asp Ala Leu Lys Arg Asn Glu Arg Ala Glu 
545                 550                 555                 560 


Arg Glu Leu His Gly Leu Arg Lys Gln Gln Arg Arg Lys Glu His Glu 
                565                 570                 575     


Arg Thr Gly Arg Ser Glu Gly Leu Gly Asn Val Ile Asp Phe Lys Arg 
            580                 585                 590         


Gln Glu Asn Glu Ala Ile Gly Thr Lys Asn Ser Gln Ile Gly Pro Ile 
        595                 600                 605             


Gln Lys Leu Val Lys Arg Leu Lys Pro Lys Arg Lys Ala Lys Val Ala 
    610                 615                 620                 


Ala Lys Asn Trp Gln Gln Lys Leu Ser Glu Asn Trp 
625                 630                 635     


<210> 18
<211> 291
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-5-C transposition protein

<400> 18
Met Ala Gln Pro Gln Leu Ile Ser Gln Gln Leu Gln Thr Gln Pro Ser 
1               5                   10                  15      


Pro Phe Pro Leu Pro Asp Lys Glu Ala Glu Ile Asp Arg Leu Arg Ala 
            20                  25                  30          


Gly Ala Pro Phe Leu Thr Thr Asp Arg Asp Thr Ala Leu Glu Gln Trp 
        35                  40                  45              


Leu Asp Thr Gln Arg Lys Ser Gly Asn Pro Gly Phe Ile Cys Ser Ala 
    50                  55                  60                  


Lys Gly Ser Gly Leu Ser Asp Ser Cys Gln Asp Tyr Arg Met Asn Arg 
65                  70                  75                  80  


Val Arg Ser Lys Gly Met Ile Gln Gln Leu Pro Val Pro Val Val Tyr 
                85                  90                  95      


Val Arg Val Pro Pro Ile Cys Ser Val Ser His Phe His Thr Thr Leu 
            100                 105                 110         


Leu Thr Ala Leu Asn His Pro Ile Thr Thr Gly Arg Leu Lys Asp Lys 
        115                 120                 125             


Arg Pro Arg Val Arg Gly Arg Leu Lys Ser Ile Gln Thr Arg Gln Leu 
    130                 135                 140                 


Ile Ile Asp Asp Ala Asp Phe Leu Ser Phe Glu Ala Leu Ser Glu Ile 
145                 150                 155                 160 


Ala Gln Ile Tyr Asp Asp Leu Lys Ile Pro Ser Ile Leu Cys Gly Thr 
                165                 170                 175     


Tyr Tyr Leu Glu Lys Arg Leu Gln Gln Arg Tyr Trp Asp Arg Ile Gly 
            180                 185                 190         


Asn Ser Phe Leu Asp Phe Tyr Glu Tyr Pro Pro Met Ser Gln Asp Glu 
        195                 200                 205             


Val Val Glu Val Ile Asp Thr Trp Glu Thr Glu Phe Leu Gln Trp Pro 
    210                 215                 220                 


Glu Glu Ser Asp Leu Leu Ile Glu Asp Val Leu Lys Ala Val Tyr Val 
225                 230                 235                 240 


Lys Thr Gly Gly Leu Arg Asp Ala Leu Asn Glu Val Leu Arg Lys Val 
                245                 250                 255     


Ala Ile Gln Ala Leu Lys Gln Asp Ser Tyr Lys Ile Thr Thr Glu Ile 
            260                 265                 270         


Ile Val Ser Val Leu Asn Gly Arg Val Gln Pro Arg Ile Lys Pro Ala 
        275                 280                 285             


Gln Glu Glu 
    290     


<210> 19
<211> 169
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-5-Q transposition protein

<400> 19
Met Thr Asp Gln Gln Thr Val Trp Met Glu His Val Glu Pro Tyr Glu 
1               5                   10                  15      


Gly Glu Ser Ile Ser His Tyr Phe Gly Arg Phe Arg Arg Val Glu Gly 
            20                  25                  30          


Asn Ser Phe Ser Ala Pro Thr Thr Leu Ser Ala Ala Val Gly Ile Gly 
        35                  40                  45              


Pro Ala Leu Ser Arg Trp Glu Lys Phe Arg Phe Asn Pro Phe Pro Ser 
    50                  55                  60                  


Pro Gln Glu Leu Glu Ala Met Gly Lys Leu Ile Gly Leu Thr Val Glu 
65                  70                  75                  80  


Gln Leu Arg Thr Met Leu Pro Ala Lys Gly Glu Arg Leu Val Met Arg 
                85                  90                  95      


Ser Thr Arg Leu Cys Gly Ala Cys Tyr Arg Glu Ala Pro Tyr His Arg 
            100                 105                 110         


Ile His Trp Gln Tyr Glu Ser Thr Glu Gly Cys Asp Lys His Arg Leu 
        115                 120                 125             


Arg Leu Ile Ser Arg Cys Pro Val Cys Asp Glu Lys Phe Ala Leu Pro 
    130                 135                 140                 


Val Glu Trp Ile Glu Gly Ala Cys Lys Gln Cys Gly Met Lys Phe Thr 
145                 150                 155                 160 


Ser Met His Lys Lys Gln Lys Pro Tyr 
                165                 


<210> 20
<211> 640
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-33 effector

<400> 20
Met Lys Glu Ser Leu Tyr Phe Val Ile Arg Cys Leu Leu Ser Ala Asp 
1               5                   10                  15      


Ala Glu Thr Arg Arg Thr Met Trp Leu Leu Met Gln Arg Tyr Thr Leu 
            20                  25                  30          


Leu Val Asn Lys Leu Leu Glu Val Ile Pro Gly Ser Ser Glu Phe Pro 
        35                  40                  45              


Val Trp Arg Glu Gln Gly Tyr Ile Pro Asp Asn Ala Leu Ala Glu Phe 
    50                  55                  60                  


Ile Asp Thr Ile Lys Pro Asp Leu Asp Tyr Ser Gly Leu Pro Gly Arg 
65                  70                  75                  80  


Phe Tyr Thr Ser Ala Lys Ile Leu Val Lys Asn Ile Tyr Lys Ser Trp 
                85                  90                  95      


Phe Ala Leu Gln Arg Lys Tyr Ser Arg Lys Ile Thr Gly Lys Ile Arg 
            100                 105                 110         


Trp Ile Lys Ile Ile Asn Ser Glu Ile Asp Leu Ile Lys Asn Thr Glu 
        115                 120                 125             


Phe Glu Leu Asp Gln Ile Thr Asn Ala Ala Asn Ala Ala Leu Lys Leu 
    130                 135                 140                 


Ala Lys Lys Lys Lys Glu Glu Ser Glu Lys Ser Asn Ser Glu Ser Ser 
145                 150                 155                 160 


Thr Ser Leu Leu Gly Ile Leu Ile Glu Met Gln Phe Lys Thr Lys Ser 
                165                 170                 175     


Pro Leu Lys Lys Arg Gly Ile Asn His Leu Leu Leu Asn Asn Leu Asn 
            180                 185                 190         


Ile Glu Tyr Lys Asp Phe Thr Leu Asp Ser Leu Glu Ala Arg Val Glu 
        195                 200                 205             


Val Ala Phe Leu Glu Ile Glu Ala Leu Glu Lys Arg Leu Arg Ser Arg 
    210                 215                 220                 


Leu Pro Lys Gly Arg Asp Pro Asp Gly Tyr Arg Tyr Val Leu Ala Leu 
225                 230                 235                 240 


Ser Lys Ala Ala Ser Leu Pro Glu Glu Ala Leu Thr Pro Glu Lys Phe 
                245                 250                 255     


Asp Glu Ile His Ala Asp Ile Pro Ile Tyr Asn Glu Leu Pro Tyr Pro 
            260                 265                 270         


Leu Ile Tyr Glu Gly Ala Ser Asn Ile Val Trp Thr Leu Ile Lys Pro 
        275                 280                 285             


Glu Gly Asn Arg Ser Asn Phe Gly Arg Leu Gln Ile His Phe Asn Gly 
    290                 295                 300                 


Ile Ser Glu Leu Lys Phe Leu Ile Gln Cys Gly Arg Arg Gln Leu Pro 
305                 310                 315                 320 


Val Phe Lys Gly Phe Tyr His Asp Ala Ile Glu Asn Lys Gly Arg Ile 
                325                 330                 335     


Ser Arg Gly Glu Ile Pro Tyr Asn Glu Gly Leu Asn Arg Phe Arg Ser 
            340                 345                 350         


Ala Gln Ile Leu Trp Lys Pro Asp Pro Ser Leu Asp Phe Arg Lys Lys 
        355                 360                 365             


Lys Lys Asn Ile Pro Ser Thr Pro Trp Glu Val Asn Arg Leu Tyr Leu 
    370                 375                 380                 


His Cys Ser Val Asp Lys Ala Thr Leu Ser Ala Glu Gly Thr Glu Cys 
385                 390                 395                 400 


Leu Arg Gln Met Lys Ile Lys Lys Ile Glu Glu Lys Lys Glu Lys Pro 
                405                 410                 415     


Leu Ser Pro Arg Lys Gln Thr Glu Leu Glu Arg Leu Gln Ser Ala Ala 
            420                 425                 430         


Pro Pro Pro Arg Pro Ser Ile Gln Pro Tyr Val Gly Asp Pro Asp Met 
        435                 440                 445             


Val Val Cys Ile Cys Phe Ser Pro Asp Glu Pro Val Ile Val Val Pro 
    450                 455                 460                 


Val Asp Leu Ala Lys Glu Ala Ala Leu Tyr Ala Leu Asn Thr Lys Ala 
465                 470                 475                 480 


Leu Leu Asn Arg Ala Thr Lys Ala Ile Trp Arg Met Gly Lys Leu Glu 
                485                 490                 495     


Thr Leu Ser Asp Asn Gly Lys Ala Leu Cys His Asp Asn Gly Gly Lys 
            500                 505                 510         


Leu Asn Ile Arg Asn Pro Arg Thr Tyr Ser Val Gln Lys Pro Tyr Gly 
        515                 520                 525             


Leu Val Thr Arg Leu Asn Thr Leu Ser Glu Gln Gln Val Lys Arg Arg 
    530                 535                 540                 


Thr Arg Glu Gln Ser Lys Gly Lys Tyr Arg Gly Ser Gln Ser Leu Ser 
545                 550                 555                 560 


Asn Leu Ser Leu Ser Val Cys Arg Leu Ile Ala Ala Arg Leu Val Asp 
                565                 570                 575     


Leu Ser Leu Gln Leu Asn Ala Gly Arg Val Ile Ile Pro Asp Phe Glu 
            580                 585                 590         


Gly Ile Arg Asp Trp Val Gln Ala Phe Ile Ala Ala Lys Ala Val Lys 
        595                 600                 605             


Ala Phe Pro Asp Ser Lys Gln Gln Gln Lys Lys Phe Arg Gln Glu Phe 
    610                 615                 620                 


Arg Ala Lys Tyr His Arg Trp Ser Tyr Arg Lys Leu Ala Gln Glu Ile 
625                 630                 635                 640 


<210> 21
<211> 612
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-34 effector

<400> 21
Met Ser Gln Ile Thr Ile Gln Cys Arg Leu Val Ala Lys Glu Pro Ile 
1               5                   10                  15      


Arg His Thr Leu Trp Gln Leu Met Ala Asp Leu Asn Thr Pro Phe Ile 
            20                  25                  30          


Asn Glu Leu Leu Gln Lys Val Ala Gln His Pro Asp Phe Glu Lys Trp 
        35                  40                  45              


Lys Gln Arg Gly Arg Leu Lys Val Lys Val Ile Glu Gln Leu Gly Asn 
    50                  55                  60                  


Glu Leu Lys Lys Asp Pro Arg Phe Leu Gly Gln Pro Ala Arg Phe Tyr 
65                  70                  75                  80  


Thr Ser Gly Ile Asn Leu Val Lys Tyr Ile Phe Lys Ser Trp Leu Lys 
                85                  90                  95      


Leu Gln Gln Arg Leu Gln Gln Lys Leu Asp Arg Lys Arg Arg Trp Leu 
            100                 105                 110         


Glu Val Leu Lys Ser Asp Asp Gln Leu Ile Lys Asp Gly Gln Thr Asp 
        115                 120                 125             


Leu Glu Thr Ile Arg Gln Lys Ala Thr Glu Ile Leu Gln Ser Tyr Glu 
    130                 135                 140                 


Gly Thr Glu Gln Leu Phe Asn Thr Leu Phe Gln Ala Tyr Asn Ser Glu 
145                 150                 155                 160 


Glu Asp Ile Leu Thr Arg Thr Ala Leu Asn Tyr Leu Leu Lys Asn Arg 
                165                 170                 175     


Cys Lys Leu Pro Gln Lys Pro Glu Asp Ala Lys Lys Phe Ala Lys Arg 
            180                 185                 190         


Arg Arg Gln Val Glu Ile Ala Ile Lys Arg Leu Gln Glu Gln Ile Lys 
        195                 200                 205             


Ala Arg Leu Pro Gln Gly Arg Asp Val Thr Asn Glu Asn Trp Leu Glu 
    210                 215                 220                 


Thr Leu Asn Leu Ala Cys Tyr Thr Asp Pro Glu Asn Ile Glu Glu Ala 
225                 230                 235                 240 


Arg Ser Trp Gln Asp Lys Leu Leu Thr Lys Ser Ser Ser Ile Pro Phe 
                245                 250                 255     


Pro Ile Asn Tyr Glu Thr Asn Glu Asp Leu Ile Trp Ser Lys Asn Glu 
            260                 265                 270         


Lys Gly His Leu Cys Val Gln Phe Asn Gly Ile Ser Asp Leu Lys Phe 
        275                 280                 285             


Lys Ile Tyr Cys Asp Lys Arg Gln Leu Lys Trp Phe Gln Arg Phe Tyr 
    290                 295                 300                 


Glu Asp Gln Gln Ile Lys Lys Ser Asn Asn Asn Gln His Ser Ser Ala 
305                 310                 315                 320 


Leu Phe Thr Leu Arg Ser Gly Arg Ile Leu Trp Gln Glu Asp Lys Gly 
                325                 330                 335     


Lys Gly Gln Leu Trp Asp Ile His Arg Leu Thr Leu Gln Cys Thr Leu 
            340                 345                 350         


Asp Thr Arg Thr Trp Thr Gln Glu Gly Thr Glu Gln Val Lys Glu Glu 
        355                 360                 365             


Lys Ala Asp Glu Ile Ala Gly Ile Leu Thr Arg Met Asn Glu Lys Gly 
    370                 375                 380                 


Asp Leu Thr Lys Asn Gln Gln Ala Phe Ile Gln Arg Lys Gln Ser Thr 
385                 390                 395                 400 


Leu Asp Lys Leu Glu Asn Pro Phe Pro Arg Pro Ser Arg Pro Val Tyr 
                405                 410                 415     


Arg Gly Gln Ser Asn Ile Leu Leu Gly Val Ser Met Glu Leu Lys Lys 
            420                 425                 430         


Pro Ala Thr Ile Ala Val Ile Asp Gly Met Thr Arg Lys Val Leu Thr 
        435                 440                 445             


Tyr Arg Asn Ile Lys Gln Leu Leu Gly Lys Asn Tyr Pro Leu Leu Asn 
    450                 455                 460                 


Arg Gln Arg Arg Gln Lys Gln Leu Gln Ser His Gln Arg Asn Val Ala 
465                 470                 475                 480 


Gln Arg Lys Glu Ala Phe Asn Gln Phe Gly Asp Ser Glu Leu Gly Glu 
                485                 490                 495     


Tyr Ile Asp Arg Leu Leu Ala Lys Ala Ile Ile Ala Ile Ala Lys Gln 
            500                 505                 510         


Tyr Gln Ala Arg Ser Ile Val Val Pro His Leu Lys Asp Ile Arg Glu 
        515                 520                 525             


Ala Ile Gln Ser Glu Ile Gln Ala Leu Ala Glu Ala Lys Ile Pro Asn 
    530                 535                 540                 


Cys Ile Glu Ala Gln Ala Glu Tyr Ala Lys Lys Tyr Arg Ile Gln Val 
545                 550                 555                 560 


His Gln Trp Ser Tyr Gly Arg Leu Ile Asp Asn Ile Gln Ala Gln Ala 
                565                 570                 575     


Ser Lys Leu Gly Ile Val Ile Glu Glu Ser Gln Gln Pro Leu Gln Gly 
            580                 585                 590         


Thr Pro Leu Gln Lys Ala Ala Glu Leu Ala Phe Lys Ala Tyr Gln Ser 
        595                 600                 605             


Arg Leu Ser Ala 
    610         


<210> 22
<211> 525
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-35 effector

<400> 22
Arg Glu Val Leu Ser Gln Leu Ser Thr Gln Ser Thr Ile Glu Gly Pro 
1               5                   10                  15      


Pro Asp Thr Gln Thr Lys Arg Pro Lys Ala Lys Ser Arg Lys Ser Lys 
            20                  25                  30          


Lys Lys Gln Ser Thr Ala Gln Asn Lys Asp Leu Ile Gly Lys Leu Tyr 
        35                  40                  45              


Lys Ala Tyr Glu Ala Thr Asn Asp Leu Thr Gln Arg Cys Ile Leu Ala 
    50                  55                  60                  


Tyr Leu Ile Lys Asp Ala Gly Thr Ile Ser Glu Glu Glu Glu Thr Pro 
65                  70                  75                  80  


Glu Ala Phe Thr His Arg Ile His Arg Lys Gln Lys Asp Ile Ala Arg 
                85                  90                  95      


Leu Glu Asp Arg Leu Gln Ala Arg Leu Pro Lys Gly Arg Asp Leu Thr 
            100                 105                 110         


Gly Asp Ile Phe Thr Asp Thr Leu Phe Ile Ala Gln His Gln Glu Pro 
        115                 120                 125             


Glu Asp Val Asn Gln Met Arg Asp Trp Gln Ala Lys Leu Leu Met Arg 
    130                 135                 140                 


Pro Ala Asp Leu Pro Asp Pro Ile Arg Tyr Asp Ser Ser Thr Asp Met 
145                 150                 155                 160 


Met Trp Lys Pro Asp Asp Gln Gly Arg Ile Thr Val Asn Phe Asn Gly 
                165                 170                 175     


Leu Glu Lys Phe Leu Lys Asn Ser Asp Leu Glu Val Lys Ser Trp Leu 
            180                 185                 190         


Lys Glu His Gln Ala Tyr Pro Phe Arg Ile Gln Cys Asp Gln Arg Gln 
        195                 200                 205             


Leu Pro Tyr Phe Gln Arg Phe Leu Ala Asp Trp Gln Ala Tyr Thr Ala 
    210                 215                 220                 


Asp Ala Glu Asn Tyr Pro Ala Gly Leu Leu Thr Leu Ser Ser Ala Met 
225                 230                 235                 240 


Leu Ala Trp Arg Lys Gly Lys Lys Asn Arg Lys Gly Glu Pro Trp Asn 
                245                 250                 255     


Ile His Gln Leu Val Leu Tyr Cys Ser Phe Asp Thr Arg Leu Leu Thr 
            260                 265                 270         


Ala Glu Gly Thr Ala Ala Val Gln Gln Gln Lys Ile Glu Lys Ala Gln 
        275                 280                 285             


Lys Gln Ala Glu Ser Ala Gln Asn Lys Lys Leu Asn Asp Asn Gln Arg 
    290                 295                 300                 


Gln Ala Arg Asn Arg Ser Ala Thr Thr Leu Arg Lys Leu Asp Asn Leu 
305                 310                 315                 320 


Pro Thr Arg Pro Ser Gln Lys Ala Tyr Gln Ala Lys Pro Glu Leu Leu 
                325                 330                 335     


Leu Gly Leu Ser Ile Gly Leu Ser Glu Pro Ile Thr Val Ala Val Val 
            340                 345                 350         


Asp Ala Ser Thr Gln Gln Val Leu Thr Tyr Arg Thr Ser His Thr Leu 
        355                 360                 365             


Leu Gly Glu Gln His Arg Leu Leu Arg Arg Gln Arg Gln Lys Gln Gln 
    370                 375                 380                 


Gln Asn Arg Leu Lys Arg Gln Gln Asn Gln Lys Lys Gly Ile Arg His 
385                 390                 395                 400 


Gln Pro Ser Glu Ser Glu Leu Gly Gln Tyr Val Asp Arg Leu Leu Ala 
                405                 410                 415     


Lys Ala Ile Thr Gln Leu Ala Gln Ser His Gln Val Ser Ser Ile Val 
            420                 425                 430         


Leu Pro Asn Leu Leu Asn Arg Arg Asp Leu Leu Asp Ser Glu Ile Gln 
        435                 440                 445             


Ala Arg Ala Glu Gln Gln Cys Pro Gly Ser Ile Ser Ala Gln Glu Lys 
    450                 455                 460                 


Tyr Ala Lys Ala Phe Arg Gln Ser Leu His Ser Trp Asp Tyr Arg Arg 
465                 470                 475                 480 


Leu Ile Glu Ala Ile Arg Gly Ser Ala Gly Lys His Asp Ile Pro Leu 
                485                 490                 495     


Glu Glu Ala Phe Leu Thr Ala Ser Ser Asp Pro Lys Glu Gln Ala Lys 
            500                 505                 510         


Glu Ile Ala Ile Ala Ala Tyr Gln Ala Arg Thr Glu Asp 
        515                 520                 525 


<210> 23
<211> 724
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-36 effector

<400> 23
Met Glu Thr Arg Glu Met Ser Gln Pro Asn Leu Pro Ala Cys Met Lys 
1               5                   10                  15      


Thr Ile Met Cys Cys Leu Cys Ala Ser Pro Glu Thr Arg Arg Tyr Phe 
            20                  25                  30          


Trp Glu Thr Met Val Ser Tyr Thr Leu Leu Val Asn Glu Leu Leu Glu 
        35                  40                  45              


Ala Val Pro Asn Arg Pro Glu Phe Pro Gln Trp Gln Arg Arg Gly Thr 
    50                  55                  60                  


Ile Asp Arg Glu Ala Val Arg Ile Val Leu Lys Pro Leu Lys Ala Lys 
65                  70                  75                  80  


Pro Asn Tyr Ala Gln Leu Pro Lys Arg Phe Phe Thr Ser Ala Glu Leu 
                85                  90                  95      


Ile Val Cys Tyr Val Tyr Lys Ser Trp Leu Ala Leu Gln Lys Arg Arg 
            100                 105                 110         


Gln Trp Gln Leu Glu Gly Lys His Arg Trp Leu Ala Ala Ile Ala Ser 
        115                 120                 125             


Asp Leu Lys Ser Ile Leu Ser Ser Asp Leu Ser Phe Glu Thr Val Gln 
    130                 135                 140                 


Ala Lys Ala Arg Gln Ile Leu Glu Gln Ala Glu Gln Asp Leu Glu Pro 
145                 150                 155                 160 


Pro Pro Pro Glu Val Thr Lys Lys Gly Lys Lys Ser Lys Arg Arg Lys 
                165                 170                 175     


Lys Ser Lys Ser Leu Leu Lys Tyr Leu Leu Asp Arg His Asp Glu Thr 
            180                 185                 190         


Thr Gln Glu Leu Glu Arg Arg Ala Ile Cys His Leu Leu Arg His Asp 
        195                 200                 205             


Leu Lys Val Ile Glu Glu Glu Asp Thr Pro Glu Thr Ile Gln His Val 
    210                 215                 220                 


Ile Asp Arg Lys Arg Ile Glu Ile Glu Arg Leu Thr Glu Gln Leu Gln 
225                 230                 235                 240 


Ser Arg Leu Pro Lys Gly Arg Asp Pro Asn His Glu Arg Phe Met Glu 
                245                 250                 255     


Arg Leu Glu Met Ala Ile Ala Leu Pro Asp Gly Ser Pro Lys His Trp 
            260                 265                 270         


Asp Pro Glu Glu Phe Asp Glu Trp Arg Ile Gln Lys Gln Ile Pro Glu 
        275                 280                 285             


Leu Asn Thr Leu Pro Tyr Pro Ile Leu Phe Gly Ser Ala Ser Asp Leu 
    290                 295                 300                 


Tyr Trp Asp Ile Leu Asn Asp Thr Thr Ser Ala Ala Thr Val Ser Ala 
305                 310                 315                 320 


Lys Lys Lys Ser Arg Lys Ser Lys Arg Pro Asn Glu Arg Leu Gln Val 
                325                 330                 335     


Arg Phe Lys Gly Leu Asp Glu His Lys Cys Lys Ile Gln Cys Asp Arg 
            340                 345                 350         


Arg Gln Leu Lys Thr Phe Arg Gln Phe Ala Thr Asp Tyr Ile Ser Asn 
        355                 360                 365             


Gln Gln Leu Pro Lys Asp Glu Lys Phe Gly Glu Gly Leu Phe Ala Leu 
    370                 375                 380                 


Arg Ser Ala Cys Leu Ile Trp Lys Val Asp Pro Asp Ala Ser Ala Ser 
385                 390                 395                 400 


Arg Arg Asn Arg Gln Lys Ala Val Leu Arg Lys Asp Ser His Leu Lys 
                405                 410                 415     


Ala Ser Leu Glu Lys Gly Glu Val Cys Leu Ile Asp Tyr Pro Trp Glu 
            420                 425                 430         


Thr His Arg Leu Tyr Leu His Cys Thr Phe Asp Ile Arg Leu Leu Thr 
        435                 440                 445             


Gln Gln Gly Thr Glu Gln Val Arg Leu Lys Lys Leu Asp Ala Ala Gln 
    450                 455                 460                 


Lys Ser Val Glu Lys Thr Gln Glu Arg Gln Ala Ala Asp Pro Ser Ile 
465                 470                 475                 480 


Thr Met Thr Ala Asn Gln Ala Ser Arg Phe Lys Ala Lys Gln Thr Ser 
                485                 490                 495     


Ile Ser Arg Leu Glu Lys Asn Arg Pro Ala Glu Arg Pro Glu Cys Gln 
            500                 505                 510         


Ile Tyr Gln Pro Asn Pro Asn Ile Val Val Gly Ile Ser Leu Ser Arg 
        515                 520                 525             


His Glu Pro Val Thr Val Val Val Phe Asn Lys Glu Lys Asn Gln Ala 
    530                 535                 540                 


Ser Glu Tyr Trp Ser Thr Glu Ser Leu Leu Lys Met Arg Gly Ile Thr 
545                 550                 555                 560 


Ser Pro Arg Asn Asn Gln Ser Ile Val Gln Leu Gln His Glu Gln Gln 
                565                 570                 575     


Gln Leu Leu Arg Arg Trp Arg Arg Gln Arg His Tyr Asn Ile Tyr Gln 
            580                 585                 590         


Arg Pro Glu Gly Gln Lys Gln Gly Asp Tyr His Gln His Asp Ala Glu 
        595                 600                 605             


Ser Arg Leu Gly Asp Tyr Leu Asp Arg Leu Ile Ala Ala Arg Val Thr 
    610                 615                 620                 


Glu Leu Ala Val Arg Arg Gln Ala Ala Ala Ile Ala Leu Pro Glu Leu 
625                 630                 635                 640 


Gln Asn Ile Arg Glu Ser Val Glu Ser Asp Ile Gln Ala Arg Ala Glu 
                645                 650                 655     


Lys Lys His Pro His His Ala Asn Leu Gln Ala Gln Tyr Ala Lys Gln 
            660                 665                 670         


Tyr Arg Arg Glu Phe His Arg Trp Ser Phe Gly Arg Phe Glu Gln Tyr 
        675                 680                 685             


Ile Thr Glu Ala Ala Lys Gln Arg Gly Ile Ala Val Tyr Lys Gly Arg 
    690                 695                 700                 


Gln Pro Lys His Gly Asn Glu Gln Glu Lys Ala Leu Ala Val Val Thr 
705                 710                 715                 720 


Asn Val Ile Ala 
                


<210> 24
<211> 618
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-37 effector

<400> 24
Met Ser Gln Lys Thr Val Arg Ala Arg Leu Ile Val Pro Glu Glu Thr 
1               5                   10                  15      


Arg Lys Ala Phe Trp Glu Leu Thr Ala Gly Asp Asn Thr Pro Leu Val 
            20                  25                  30          


Asn Glu Ala Leu Arg Leu Leu Pro Thr His Ser Asp Phe Ser Lys Trp 
        35                  40                  45              


Arg Gln Lys Gly Asn Leu Pro Asp Lys Ile Ala Glu Asp Leu Val Lys 
    50                  55                  60                  


Thr Leu Lys Glu Asp Leu Arg Phe Val Gly Gln Pro Phe Trp Ser Tyr 
65                  70                  75                  80  


Ile Ser Ala His Lys Gln Val Thr Tyr Thr Phe Arg Ser Trp Leu Ala 
                85                  90                  95      


Leu Gln His Arg Lys Gln Trp Lys Leu Ala Gly Lys Arg Leu Trp Leu 
            100                 105                 110         


Glu Ile Leu Gln Pro Asp Glu Ile Leu Ala Glu Ser Val Gly Tyr Thr 
        115                 120                 125             


Pro Asp Ala Leu Ile Lys Ala Ala Lys Lys Asn Leu Ala Asp Ile Glu 
    130                 135                 140                 


Ala Gln Asp Asn Pro Phe Asp Ala Leu Phe Ser Ala Tyr Arg Lys Thr 
145                 150                 155                 160 


Lys Ser Leu Lys Arg Lys Ser Ala Ile Ala Tyr Leu Leu Lys Arg Ser 
                165                 170                 175     


Ala Lys Leu Leu Pro Glu Glu Glu Asp Ile Ala Lys Leu Ala Gln Arg 
            180                 185                 190         


Tyr Arg Lys Thr Glu Ile Phe Ile Gln Arg Leu Glu Ala Gln Leu Lys 
        195                 200                 205             


Ala Ser Leu Pro Lys Gly Arg Asp Met Ser Gly Asp Arg Gln Leu Glu 
    210                 215                 220                 


Ala Leu Gln Gln Ile Ile Gln Ala Pro Pro Met Asp Asp Val Ser Tyr 
225                 230                 235                 240 


Asn Ala Trp Lys Asn Ala Leu Thr Thr Glu Pro Ala Ala Phe Pro Phe 
                245                 250                 255     


Pro Ile Ser Ile Glu Thr Ala Ala Trp Leu Ile Trp Ser Gln Asp Asp 
            260                 265                 270         


Lys Gly Arg Leu Leu Leu Gln Leu Ser Gly Trp Gly Gln His Thr Phe 
        275                 280                 285             


Lys Val Tyr Phe Asp Lys Ala His Gln His Trp Phe Trp Arg Phe Leu 
    290                 295                 300                 


Gln Asp Gln Glu Thr Asn Gln Asn Gly Gly Asp Gln His Ser Ala Ala 
305                 310                 315                 320 


Leu Phe Thr Leu Arg Ala Ala Lys Ile Met Trp Phe Pro Ser Lys Lys 
                325                 330                 335     


His Lys Asp Ala Pro Glu Pro Trp His Arg Tyr His Leu Asn Leu Leu 
            340                 345                 350         


Cys Thr Ile Asp Thr Arg Ala Trp Thr Gln Glu Gly Thr Glu Ile Ile 
        355                 360                 365             


Ala Gln Glu Lys Ala Val Lys Thr Ala Lys Gln Leu Ala Ser Met Arg 
    370                 375                 380                 


Lys Lys Glu Ser Leu Thr Gln Asn Gln Gln Gly Tyr Ile Arg Arg Leu 
385                 390                 395                 400 


Glu Ser Thr Leu Asn Arg Leu Gln Val Pro Tyr Pro Arg Pro Ser Arg 
                405                 410                 415     


Pro Ile Tyr Gln Gly Lys Pro Glu Ile Leu Val Gly Val Ser Met Gly 
            420                 425                 430         


Leu Glu Lys Val Ala Thr Val Ala Val Val Asn Ala Leu Thr Gly Arg 
        435                 440                 445             


Val Leu Thr Tyr Arg Ser Glu Lys Gln Leu Leu Gly Glu Asn Tyr Pro 
    450                 455                 460                 


Leu Leu Arg Gln Ala Arg Ala Glu Ile Ala Lys Lys Ser His Gln Gly 
465                 470                 475                 480 


His Arg Gln Arg Leu Arg Gly Val Lys Ser Ile Ser Lys Glu Ser Asp 
                485                 490                 495     


Lys Gly Lys Gln Val Asp Arg Leu Phe Ala Lys Ala Ile Val Glu Leu 
            500                 505                 510         


Val Val Glu His Gln Ala Gly Ser Ile Val Leu Pro Asp Leu Ala Tyr 
        515                 520                 525             


Lys Arg Glu Ile Ile Glu Ala Glu Phe Gln Gln Arg Ala Ile Glu Lys 
    530                 535                 540                 


Val Pro Asp Phe Val Asp Gly Gln Lys Glu Tyr Ala Lys Ala Tyr Leu 
545                 550                 555                 560 


Ser Gln Val His Arg Trp Pro Tyr Ala Arg Leu Gln Gly Cys Thr Thr 
                565                 570                 575     


Ser Lys Ala Glu Gln Ser Gly Ile Ser Cys Glu Ile Thr Lys Gln Gln 
            580                 585                 590         


Tyr Ser Gly Thr Pro Gln Asp Lys Ala Lys Gly Leu Gly Phe Leu Ala 
        595                 600                 605             


Tyr Ser Gln Arg Ser Thr Ala Leu Ala Glu 
    610                 615             


<210> 25
<211> 661
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-38 effector

<400> 25
Met Ser Ile Ile Thr Ile His Cys His Leu His Thr Thr Glu Ala Ile 
1               5                   10                  15      


Arg Arg Leu Leu Trp Gln Val Met Ala Ala Ser Asn Thr Pro Leu Ile 
            20                  25                  30          


Ser Thr Leu Leu Arg His Val Ala Glu His Pro Asp Phe Asp Thr Trp 
        35                  40                  45              


Gln Thr Asn Gly Ser Val Pro Val Lys Thr Val Arg Asn Ile Ala Glu 
    50                  55                  60                  


Pro Leu Lys Ala His Tyr Pro Ser Gln Pro Gly Arg Phe Tyr Ala Ser 
65                  70                  75                  80  


Ala Tyr Gln Met Val Ser Tyr Thr Tyr Glu Ser Trp Leu Ala Thr Gln 
                85                  90                  95      


Lys Met Ile Lys Leu Arg Leu Asp Gly Thr Arg Arg Trp Leu Ser Ile 
            100                 105                 110         


Phe Lys Ser Asp Ala Glu Leu Leu Glu Leu Thr Gly Leu Ser Leu Glu 
        115                 120                 125             


Ser Leu Arg Gln Ser Ala Arg Glu Val Leu Ser Gln Leu Ser Thr Gln 
    130                 135                 140                 


Ser Thr Ala Gly Arg Pro Ser Asp Thr Gln Thr Lys Pro Pro Lys Ala 
145                 150                 155                 160 


Lys Ser Arg Lys Ser Lys Lys Lys Gln Ala Thr Ala Gln Asp Lys Asp 
                165                 170                 175     


Leu Ile Gly Lys Leu Phe Lys Ala Tyr Glu Ala Thr Asp Asp Leu Thr 
            180                 185                 190         


Gln Arg Cys Ile Leu Ala Tyr Leu Ile Lys Asn Gly Gly Thr Ile Thr 
        195                 200                 205             


Asp Glu Ala Glu Thr Pro Glu Ala Phe Ala His Arg Leu His Arg Lys 
    210                 215                 220                 


Gln Lys Asp Ile Ala Gln Leu Glu Asn Arg Leu Gln Ala Arg Leu Pro 
225                 230                 235                 240 


Lys Gly Arg Asp Leu Thr Gly Asp Thr Phe Ile Asp Thr Leu Leu Ile 
                245                 250                 255     


Ala Gln Gln Gln Glu Pro Glu Asp Val Ala Gln Met Arg Asp Trp Gln 
            260                 265                 270         


Ala Lys Leu Leu Met Arg Pro Ala Asp Leu Pro Tyr Pro Ile Arg Tyr 
        275                 280                 285             


Asp Ser Ser Thr Asp Met Met Trp Lys Pro Asp Asp Gln Glu Arg Ile 
    290                 295                 300                 


Thr Val Asn Phe Asn Gly Leu Glu Lys Phe Leu Lys Asn Ser Asp Pro 
305                 310                 315                 320 


Ala Val Lys Ala Trp Leu Lys Glu His Lys Glu Tyr Pro Phe Arg Ile 
                325                 330                 335     


Gln Cys Asp Gln Arg Gln Leu Pro Tyr Phe Gln Arg Phe Leu Thr Asp 
            340                 345                 350         


Trp Gln Ala Tyr Thr Ala Asp Lys Ala Asn Tyr Pro Ala Gly Leu Leu 
        355                 360                 365             


Thr Leu Ser Ser Ala Met Leu Ala Trp Arg Lys Ser Lys Lys Lys Arg 
    370                 375                 380                 


Lys Gly Glu Pro Trp Asn Thr Tyr Gln Leu Ala Leu Tyr Cys Ser Phe 
385                 390                 395                 400 


Asp Thr Arg Leu Leu Thr Ala Glu Gly Thr Val Glu Val Gln Gln Glu 
                405                 410                 415     


Lys Leu Arg Lys Ala Gln Lys Gln Ala Asn Ser Thr Lys Asp Lys Lys 
            420                 425                 430         


Leu Asp Glu Asn Gln Leu Gln Ala Gln Thr Arg Ser Ala Thr Ser Leu 
        435                 440                 445             


Arg Lys Leu Glu Asn Leu Pro Ala Arg Pro Ser Arg Lys Pro Tyr Glu 
    450                 455                 460                 


Gly Lys Ser Glu Leu Leu Leu Gly Ile Ser Ile Gly Phe Ser Glu Pro 
465                 470                 475                 480 


Val Thr Val Ala Ile Val Asp Ala Ser Thr Gln Gln Ala Ile Thr Tyr 
                485                 490                 495     


Arg Thr Ser Arg Thr Leu Leu Gly Asp Gln His Arg Leu Leu Arg Arg 
            500                 505                 510         


Gln Arg Gln Gln Lys Gln Gln Asn Arg Leu Lys Arg Gln Gln Asn Gln 
        515                 520                 525             


Lys Lys Gly Ile Arg His Gln Pro Ser Glu Ser Glu Leu Gly Gln Tyr 
    530                 535                 540                 


Val Asp Arg Leu Leu Ala Lys Ala Ile Ile Gln Leu Ala Gln Thr His 
545                 550                 555                 560 


Gln Val Ser Ser Ile Val Leu Pro Asn Leu Thr Asn Asp Arg Asp Ile 
                565                 570                 575     


Leu Asn Ser Glu Ile Gln Ala Arg Ala Glu Gln Lys Cys Pro Gly Ala 
            580                 585                 590         


Ile Ala Ala Gln Ala Lys Tyr Ala Lys Glu Val Arg Ile Ser Ile His 
        595                 600                 605             


Ser Trp Asp Tyr Arg Arg Leu Ser Asp Ala Ile Arg Ser Ser Ala Ser 
    610                 615                 620                 


Lys Gln Gly Ile Pro Leu Glu Glu Ala Phe Leu Thr Val Arg Thr Asn 
625                 630                 635                 640 


Pro Lys Glu Gln Ala Arg Glu Leu Ala Ile Ala Ala Tyr Gln Ala Arg 
                645                 650                 655     


Thr Glu Asn Arg Asn 
            660     


<210> 26
<211> 625
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-39 effector

<400> 26
Ala Ser Ser Thr His Lys Pro Met Ser Gln Lys Thr Ile Arg Cys Arg 
1               5                   10                  15      


Leu Val Ala Ser Glu Glu Thr Arg Arg Ala Ile Trp Gln Leu Met Ala 
            20                  25                  30          


Glu Arg Asn Thr Pro Leu Val Asn Glu Val Leu Arg Gln Leu Pro Glu 
        35                  40                  45              


His Pro Asp Phe Pro Lys Trp Gln Gln Arg Gly Lys Leu Pro Asp Leu 
    50                  55                  60                  


Pro Val Lys Arg Leu Ile Asp Ser Leu Lys Pro Asp Pro Arg Phe Cys 
65                  70                  75                  80  


Asp Gln Pro Val Trp Tyr Tyr Ile Ser Ala Gln Lys Gln Val Ala Tyr 
                85                  90                  95      


Thr Phe Arg Ser Trp Leu Ser Leu Gln Lys Arg Lys Gln Trp Arg Leu 
            100                 105                 110         


Glu Gly Lys Arg Arg Trp Leu Asp Ile Leu Gln Pro Asp Ala Glu Leu 
        115                 120                 125             


Ala Glu Gln Ala Lys Cys Ser Val Glu Ala Leu Arg Leu Ala Ala Ser 
    130                 135                 140                 


Asn Met Leu Lys Lys Val Asp Asp Pro Asp Pro Phe Lys Leu Leu Phe 
145                 150                 155                 160 


Lys Glu Tyr Gly Thr Ser Lys Ser Thr Lys Arg Gln Cys Ala Leu Ala 
                165                 170                 175     


Tyr Leu Leu Lys Arg Asp Ala Lys Leu Glu Pro Glu Ala Glu Asp Leu 
            180                 185                 190         


Glu Lys Leu Asp Gln Arg Arg Ser Lys Ala Glu Ile Gln Ile Lys Gln 
        195                 200                 205             


Leu Glu Thr Gln Leu Lys Ala Ser Leu Pro Lys Gly Arg Asp Leu Thr 
    210                 215                 220                 


Gly Gln Ile Gln Ala Gln Ala Leu Thr Gln Ser Val Gln Ser Pro Pro 
225                 230                 235                 240 


Leu Asp Asp Glu Ala Tyr Ser Thr Trp His Ala Ser Leu Ala Arg Glu 
                245                 250                 255     


Pro Ala Ile Phe Pro Phe Pro Ile Ile Tyr Glu Thr Ile Glu Ser Leu 
            260                 265                 270         


Val Trp Ser Lys Asn Ser Lys Gly Arg Tyr Ser Val Cys Phe Gln Gly 
        275                 280                 285             


Gln Gly Thr Gly Ile His Thr Phe Lys Ile Tyr Cys Asp Lys Pro His 
    290                 295                 300                 


Gln His Trp Phe Glu Arg Phe Trp Ile Asp Gln Glu Thr Lys Arg Ser 
305                 310                 315                 320 


Gly Asn Asp Arg His Ser Ala Gly Leu Phe Thr Leu Arg Ser Ala Arg 
                325                 330                 335     


Leu Ser Trp Ile Pro Ser Lys Lys His Gln Asp Glu Pro Glu Pro Trp 
            340                 345                 350         


Asn Arg Tyr Tyr Leu Ser Leu Ser Cys Thr Val Asp Thr Ala Leu Trp 
        355                 360                 365             


Thr Gln Glu Gly Thr Gln Thr Val Ile Gln Glu Lys Ala Val Ala Thr 
    370                 375                 380                 


Ala Ser Lys Leu Gln Ser Met Gln Glu Lys Glu Ser Leu Asn Lys Asn 
385                 390                 395                 400 


Gln Gln Gly Tyr Val Arg Arg Leu Glu Ser Thr Leu Thr Arg Leu Gln 
                405                 410                 415     


Thr Pro Tyr Pro Arg Pro Ser Arg Ala Leu Tyr Gln Gly Arg Ser Asp 
            420                 425                 430         


Ile Leu Val Gly Val Ser Met Gly Leu Asp Lys Pro Ala Thr Val Ala 
        435                 440                 445             


Val Val Asn Ala Leu Thr Gly Glu Val Leu Thr Tyr Arg Ser Thr Lys 
    450                 455                 460                 


Gln Leu Leu Gly Glu Gln Tyr Pro Leu Leu Gln Arg Ala Arg Ser Glu 
465                 470                 475                 480 


Arg Ala Lys Val Ala His Gln Gly His Arg Gln Arg Arg Lys Gly Gly 
                485                 490                 495     


Lys Arg Val Asn Gln Glu Ser Asn Leu Gly Lys His Val Asp Arg Leu 
            500                 505                 510         


Leu Ala Lys Ala Ile Val Glu Val Ala Gln Gln Tyr Gln Ala Gly Ser 
        515                 520                 525             


Ile Val Leu Pro Asp Leu Ala His Ile Arg Glu Ile Val Glu Ser Glu 
    530                 535                 540                 


Val Lys Gln Lys Ala Ala Lys Lys Val Pro Asp Phe Leu Asp Gly Gln 
545                 550                 555                 560 


Lys Gln Tyr Ala Lys Ala Tyr Arg Thr Gln Val His Gln Trp Ser Tyr 
                565                 570                 575     


His Arg Leu Gln Asp Ala Ile Thr Ser Lys Ala Gly Gln Ser Ser Ile 
            580                 585                 590         


Ala Thr Glu Val Ala Lys Gln Asp Tyr Ser Gly Ser Pro Gln Glu Lys 
        595                 600                 605             


Ala Lys Ser Leu Cys Leu Ala Gly Tyr Glu Gln Arg Leu Ala Leu Ser 
    610                 615                 620                 


Ser 
625 


<210> 27
<211> 595
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-40 effector

<400> 27
Met Ala Glu Arg Asn Thr Pro Leu Val Asn Glu Val Leu Arg Gln Leu 
1               5                   10                  15      


Pro Glu His Pro Asp Phe Ala Lys Trp Gln Gln Lys Gly Asn Leu Pro 
            20                  25                  30          


Asp Val Ala Val Lys Arg Ile Ile Asp Ala Leu Lys Ser Asp Pro His 
        35                  40                  45              


Phe Ser Asp Gln Pro Phe Trp Tyr Tyr Thr Ser Ala Gln Lys Gln Val 
    50                  55                  60                  


Thr Tyr Thr Phe Lys Ser Trp Leu Ser Ile Gln Arg Arg Lys Gln Trp 
65                  70                  75                  80  


Arg Leu Gln Gly Lys Arg Phe Trp Leu Glu Ile Leu Leu Pro Asp Ala 
                85                  90                  95      


Lys Leu Ala Glu Leu Ala Glu Cys Ser Val Glu Lys Leu Arg Thr Glu 
            100                 105                 110         


Ala Ala Lys Ile Leu Thr Lys Val Gly Asp Val Asp Pro Phe Lys His 
        115                 120                 125             


Leu Leu Glu Gln Tyr Arg His Glu Lys Lys Leu Leu Arg Lys Tyr Ala 
    130                 135                 140                 


Ile Ala Phe Leu Leu Lys Arg Asn Thr Gly Ile Asp Arg Glu Glu Asp 
145                 150                 155                 160 


Leu Glu Gln Leu Lys Gln Arg Ser Arg Arg Val Glu Leu Gln Ile Arg 
                165                 170                 175     


Arg Leu Glu Ile Gln Leu Gln Ala Ser Leu Pro Lys Gly Arg Asp Leu 
            180                 185                 190         


Thr Gly Glu Arg Gln Ala Ala Ala Leu Ala Gln Ser Val Leu Ala Ser 
        195                 200                 205             


Pro Asp Asp Asp Glu Ser Tyr Glu Leu Trp Arg Asn Thr Val Thr Arg 
    210                 215                 220                 


Glu Pro Ala Gln Phe Pro Phe Pro Val Ile Cys Glu Thr Ser Glu Trp 
225                 230                 235                 240 


Leu Lys Trp Gln Arg Asp Gln Asn Gly Arg Ile Ser Val Gly Phe Ser 
                245                 250                 255     


Ala Leu Ser Glu His Val Phe Lys Ile Tyr Cys Asp Lys Pro His Gln 
            260                 265                 270         


His Trp Phe Asn Arg Phe Phe Glu Asp Gln Glu Thr Lys Arg Ser Gly 
        275                 280                 285             


Gly Lys Gln His Ser Ala Gly Leu Phe Thr Leu Arg Ser Ala Lys Leu 
    290                 295                 300                 


Thr Trp Val Pro Ser Asn Lys His Ala Asn Ala Ser Glu Pro Trp Asn 
305                 310                 315                 320 


Cys Tyr Tyr Leu Asn Leu Ser Cys Thr Val Asp Thr Arg Leu Trp Thr 
                325                 330                 335     


Gln Glu Gly Thr Gln Ile Val Ile Gln Glu Lys Ala Ala Glu Lys Ala 
            340                 345                 350         


Gly Lys Leu Glu Ser Met Arg Arg Lys Glu Asn Leu Ser Lys Thr Gln 
        355                 360                 365             


Gln Gly Tyr Ile Lys Arg Leu Glu Ala Thr Leu Asp Lys Leu Gln Thr 
    370                 375                 380                 


Pro Tyr Pro Arg Pro Ser Arg Gln Leu Tyr Ser Gly Lys Ala Asn Ile 
385                 390                 395                 400 


Leu Ala Gly Val Ser Met Gly Leu Asp Lys Pro Ala Thr Val Ala Val 
                405                 410                 415     


Val Asp Ala Leu Thr Gly Glu Val Leu Thr Tyr Arg Ser Val Lys Gln 
            420                 425                 430         


Leu Leu Gly Glu Asn His Gln Leu Leu Arg Arg Ala Gln Ile Glu Lys 
        435                 440                 445             


Thr Lys Ile Ala His Arg Gly His Lys Asn Arg Arg Gln Gly Gly Arg 
    450                 455                 460                 


Lys Val Ser Glu Glu Ser Asn Val Ala Gln Gln Val Asp Arg Leu Leu 
465                 470                 475                 480 


Ala Lys Ser Ile Val Glu Ile Ala Arg Lys Tyr Gln Ala Ser Ser Ile 
                485                 490                 495     


Val Val Pro Asp Leu Ala Asp Ile Arg Glu Ile Val Glu Thr Glu Val 
            500                 505                 510         


Lys Ala Arg Ala Gln Asp Lys Val Pro Asp Phe Val Glu Gly Gln Gln 
        515                 520                 525             


Gln Tyr Ala Lys Ala Tyr Arg Thr Gln Val His Gln Trp Ser Tyr Arg 
    530                 535                 540                 


Arg Leu Gln Glu Ala Val Arg Thr Lys Ala Glu Gln Ser Gly Ile Thr 
545                 550                 555                 560 


Ile Glu Val Val Arg Gln Gly Leu Ser Gly Thr Gln His Glu Lys Ala 
                565                 570                 575     


Lys Ala Leu Ala Leu Gln Gly Tyr Glu Lys Arg Ile Arg Glu His Val 
            580                 585                 590         


Glu Met Ala 
        595 


<210> 28
<211> 537
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-41 effector

<400> 28
Gln Leu Ala Gly Gln Asn Arg Trp Leu Glu Val Leu Gln Asn Asp Glu 
1               5                   10                  15      


Thr Leu Met Ala Val Ser Gly Leu Glu Ile Gln Ala Leu Arg Ala Glu 
            20                  25                  30          


Ser Thr Lys Leu Leu Asp Leu Leu Ser Ser Gln Ile Thr Lys Pro Ala 
        35                  40                  45              


Lys Gly Ser Lys Lys Thr Asn Arg Gly Lys Gly Lys Lys Gln Ala Lys 
    50                  55                  60                  


Gln Thr Gln Gly Lys Thr Leu Tyr Gln Ser Leu Trp Asp Leu Tyr Arg 
65                  70                  75                  80  


Glu Thr Glu Asp Ile Leu Gln Lys Cys Ala Ile Ala Tyr Leu Leu Lys 
                85                  90                  95      


Asn Lys Cys Gln Val Pro Gly Lys Pro Glu Asp Pro Glu Lys Phe Gln 
            100                 105                 110         


His Arg Arg Arg Lys Ala Glu Ile Arg Ala Glu Arg Leu Asn Glu Gln 
        115                 120                 125             


Leu Ile Glu Thr Arg Leu Pro Lys Gly Arg Asp Leu Thr Asn Glu Gln 
    130                 135                 140                 


Trp Leu Glu Ala Leu Lys Ile Ala Thr Glu Gln Val Pro Lys Asp Glu 
145                 150                 155                 160 


Glu Glu Ala Ala Ile Trp Gln Ser Arg Leu Leu Thr Asn Ala Ala Lys 
                165                 170                 175     


Phe Pro Phe Pro Val Ala Tyr Glu Thr Asn Glu Asp Leu Lys Trp Phe 
            180                 185                 190         


Leu Asn Gly Lys Gly Arg Leu Cys Val Arg Phe Asn Gly Leu Ser Glu 
        195                 200                 205             


His Thr Phe Lys Ile Tyr Cys Asp Gln Arg Gln Leu His Trp Phe Lys 
    210                 215                 220                 


Arg Phe Leu Glu Asn Lys Gln Asn Lys Lys Asp Asn Lys Gly Lys His 
225                 230                 235                 240 


Thr Ser Gly Leu Phe Thr Leu Arg Ser Gly Arg Ile Leu Trp Lys Pro 
                245                 250                 255     


His Ser Gly Val Val Lys Asn Ala Pro Trp Thr Val Asn His Leu Thr 
            260                 265                 270         


Leu Gln Cys Ser Val Asp Thr Arg Leu Trp Thr Ala Glu Gly Thr Glu 
        275                 280                 285             


Gln Val Arg Gln Glu Lys Ala Thr Ser Ile Ala Lys Val Ile Ala Gly 
    290                 295                 300                 


Thr Lys Ala Lys Gly Asn Leu Asn Arg Asn Gln Leu Asp Ser Ile Ser 
305                 310                 315                 320 


Asn Arg Glu Lys Thr Leu Glu Leu Met His Asn Pro Phe Pro Arg Pro 
                325                 330                 335     


Ser Gln Pro Ile Tyr Gln Gly Asn Pro Ser Ile Ile Ala Ala Val Ser 
            340                 345                 350         


Phe Gly Leu Glu Lys Pro Ala Thr Leu Ala Ile Val Asp Val Ile Thr 
        355                 360                 365             


Gly Lys Ala Ile Thr Tyr Arg Ser Ile Arg Gln Leu Leu Gly Asn Ser 
    370                 375                 380                 


Tyr Lys Leu Phe Asn Lys Gln Arg Leu Lys Gln Lys Gln Arg Asp Tyr 
385                 390                 395                 400 


Trp Arg His Lys Asn Gln Gln Lys Ser Ala Asp Asn Arg Ile Ser Glu 
                405                 410                 415     


Gly Gly Leu Gly Asp Tyr Val Asp Ser Leu Ile Ala Lys Ser Ile Val 
            420                 425                 430         


Asp Thr Ala Ala Arg Tyr Glu Ala Val Ser Ile Val Leu Pro Asp Gln 
        435                 440                 445             


Ser Asn Ile Arg Glu Ile Ile His Ala Glu Ile Gln Ala Lys Ala Glu 
    450                 455                 460                 


Arg Lys Ile Pro Gly Leu Lys Glu Lys Gln Asp Lys Tyr Ala Ala Gln 
465                 470                 475                 480 


Tyr Arg Arg Ser Val His Arg Trp Ser Tyr Gly Arg Leu Ser Gln Lys 
                485                 490                 495     


Ile Thr Thr Lys Ala Ala Ile His Gly Val Ala Ile Glu Ile Thr Arg 
            500                 505                 510         


Gln Pro Leu Gln Gly Thr Pro Gln Glu Lys Ala Val Gly Leu Ala Val 
        515                 520                 525             


Ser Ala Tyr Gln Ser Arg Gln Val Gly 
    530                 535         


<210> 29
<211> 643
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-42 effector

<400> 29
Met Ser Gln Ile Thr Val Gln Cys Arg Leu Val Ala Ser Glu Glu Thr 
1               5                   10                  15      


Arg Gln Tyr Leu Trp Tyr Leu Met Ala Asp Ile Tyr Thr Pro Phe Val 
            20                  25                  30          


Asn Glu Met Leu Arg Gln Ile Arg Glu Asp Asp Asn Phe Glu Gln Trp 
        35                  40                  45              


Arg Gln Ala Gly Lys Ile Pro Ala Gly Val Phe Glu Asp Tyr Arg Lys 
    50                  55                  60                  


Ala Leu Lys Thr Glu Ser Arg Phe Gln Gly Met Pro Gly Arg Trp Tyr 
65                  70                  75                  80  


Tyr Ala Gly Arg Glu Glu Val Lys Arg Ile Tyr Lys Ser Trp Leu Ala 
                85                  90                  95      


Leu Arg Arg Arg Leu Arg Asn Gln Leu Ser Gly Gln Asn Arg Trp Leu 
            100                 105                 110         


Glu Val Leu Gln Ser Asp Glu Thr Leu Met Ala Val Ser Gly Leu Asp 
        115                 120                 125             


Leu Pro Ala Leu Arg Ala Ala Ser Thr Lys Leu Leu Asp Leu Leu Ser 
    130                 135                 140                 


Ser Gln Ile Ala Lys Pro Ala Lys Gly Ser Lys Lys Thr Asn Arg Gly 
145                 150                 155                 160 


Lys Gly Lys Lys Gln Ala Lys Gln Thr Gln Gly Lys Ser Leu Tyr Gln 
                165                 170                 175     


Ser Leu Trp Asp Leu Tyr Lys Glu Thr Glu Asp Ile Leu Gln Lys Cys 
            180                 185                 190         


Ala Ile Ala Tyr Leu Leu Lys Asn Lys Ser Gln Val Pro Asp Lys Pro 
        195                 200                 205             


Glu Asp Pro Glu Lys Phe Arg His Arg Arg Arg Lys Ala Glu Ile Arg 
    210                 215                 220                 


Thr Glu Arg Leu Asn Glu Gln Leu Thr Lys Thr Arg Leu Pro Lys Gly 
225                 230                 235                 240 


Arg Asp Leu Thr Asn Glu Gln Trp Leu Glu Ala Leu Ala Ile Ala Thr 
                245                 250                 255     


Glu Gln Ile Pro Lys Asp Glu Thr Glu Ala Ala Ile Trp Gln Ser Arg 
            260                 265                 270         


Leu Leu Thr Asp Ala Ala Ser Leu Pro Phe Pro Val Ala Tyr Glu Thr 
        275                 280                 285             


Asn Glu Asp Leu Lys Trp Phe Leu Asn Gly Lys Gly Arg Leu Cys Val 
    290                 295                 300                 


Ser Phe Asn Gly Leu Ser Glu His Thr Phe Glu Ile Tyr Cys Asp Lys 
305                 310                 315                 320 


Arg Gln Leu His Trp Phe Lys Arg Phe Leu Glu Asp Gln Gln Ile Lys 
                325                 330                 335     


Lys Glu His Gln Gly Lys Arg Ser Ser Gly Leu Phe Thr Leu Arg Ser 
            340                 345                 350         


Gly Arg Ile Ser Trp Thr Ser Pro Ser Asp Ile Asp Lys Ser Pro Cys 
        355                 360                 365             


Trp Thr Ala Asn Arg Leu Thr Leu His Cys Ser Val Asp Thr Arg Leu 
    370                 375                 380                 


Trp Thr Gln Glu Gly Thr Glu Glu Val Arg Gln Glu Lys Ala Thr Asn 
385                 390                 395                 400 


Ile Ala Lys Ile Ile Ala Gly Thr Lys Ala Lys Gly Asn Leu Asn Gln 
                405                 410                 415     


Lys Gln Gln Asp Phe Ile Thr Lys Arg Glu Thr Thr Leu Lys Leu Leu 
            420                 425                 430         


His Asn Pro Phe Pro Arg Pro Ser Lys Pro Leu Tyr Gln Gly Asn Pro 
        435                 440                 445             


Ser Ile Ile Ala Ala Val Ser Phe Gly Leu Glu Lys Pro Ala Thr Leu 
    450                 455                 460                 


Ala Ile Val Asp Ile Thr Thr Gly Lys Ala Ile Thr Tyr Arg Ser Ile 
465                 470                 475                 480 


Arg Gln Leu Leu Asp Gln Asn Tyr Lys Leu Phe Thr Lys His Arg Leu 
                485                 490                 495     


Gln Gln Gln Gln Arg Ala His Gln Arg His Gln Asn Gln Lys Glu Ser 
            500                 505                 510         


Ala Glu Asn Arg Ile Ser Glu Gly Gly Leu Gly Glu His Val Asp Ser 
        515                 520                 525             


Leu Ile Ala Lys Ala Ile Leu Glu Thr Ala Ala Glu Tyr Gly Ala Ser 
    530                 535                 540                 


Ser Ile Val Leu Pro Glu Leu Gly Asn Ile Arg Glu Ile Ile Gln Ala 
545                 550                 555                 560 


Glu Val Ile Ala Lys Ala Glu Arg Lys Ile Pro Gly Leu Lys Glu Lys 
                565                 570                 575     


Gln Asp Glu Tyr Ala Ala Lys Phe Arg Ala Ser Val His Arg Trp Ser 
            580                 585                 590         


Tyr Gly Arg Leu Ala Gln Lys Ile Thr Thr Lys Ala Ala Leu Gln Gly 
        595                 600                 605             


Leu Glu Thr Glu Ser Thr Arg Gln Pro Leu Gln Gly Ser Pro Gln Glu 
    610                 615                 620                 


Lys Ala Arg Asn Leu Ala Ile Ala Ala Tyr Glu Ser Arg Lys Val Asp 
625                 630                 635                 640 


Gln Arg Ala 
            


<210> 30
<211> 526
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-43 effector

<400> 30
Met Pro Thr Thr Leu Ala Pro Lys Arg Pro Leu Ser Lys Ser Ser Asp 
1               5                   10                  15      


Tyr Met Lys Thr Ile Arg Cys Cys Leu Cys Ala Asn Pro Glu Thr Arg 
            20                  25                  30          


Arg Tyr Phe Trp Lys Ile Met Val Thr Tyr Thr Leu Leu Val Asn Glu 
        35                  40                  45              


Leu Leu Ala Ala Met Pro Gln Arg Pro Glu Phe Ala Gln Trp Lys Gln 
    50                  55                  60                  


Arg Gly Thr Ile Ala Arg Glu Ala Val Arg Ile Val Leu Thr Pro Leu 
65                  70                  75                  80  


Lys Ser Asp Pro Thr Tyr Ala Asp Leu Pro Lys Arg Phe Phe Ser Ser 
                85                  90                  95      


Ala Glu Leu Leu Val Cys Tyr Val Tyr Lys Ser Trp Leu Ala Leu Gln 
            100                 105                 110         


Lys Arg Arg Tyr Trp Lys Leu Val Gly Lys Gln Arg Trp Leu Gln Val 
        115                 120                 125             


Ile Glu Asp Asp Leu Gln Ser Leu Leu Thr Asp Asn Phe Ser Leu Glu 
    130                 135                 140                 


Ser Val Gln Ser Lys Ala His Gln Ile Leu Glu Gln Ala His Lys Glu 
145                 150                 155                 160 


Leu Glu Lys Gln Pro Gln Arg Phe Lys Lys Lys Gly Lys Lys Ser Arg 
                165                 170                 175     


Pro Leu Phe Gly Tyr Leu Leu Asp Leu Tyr Gly Thr Thr Ala Asp Lys 
            180                 185                 190         


Leu Glu Arg Arg Ala Ile Gly His Leu Leu His His Asp Leu Lys Val 
        195                 200                 205             


Ser Asp Thr Glu Asp Phe Pro Glu Thr Ile Gln Phe Ser Ile Asp Gln 
    210                 215                 220                 


Gln Gln Val Glu Ile Ala Arg Leu Lys Glu Gln Leu Gln Ser Arg Leu 
225                 230                 235                 240 


Pro Asp Gly Arg Asp Pro Thr Gln Ala Arg Phe Leu Glu Lys Leu Arg 
                245                 250                 255     


Ile Ala Thr Ala Leu Pro Glu Leu Glu Leu Glu Gly Phe Asp Glu Glu 
            260                 265                 270         


His Phe Ser Glu Trp Arg Thr Gln Lys Gln Ile Pro Leu Leu Asn Pro 
        275                 280                 285             


Leu Pro Tyr Pro Val Leu Phe Gly Ser Ser Ser Asp Leu His Trp Lys 
    290                 295                 300                 


Leu Glu Pro Gln Lys Ala Thr Thr Glu Ala Asn Ile Ser Pro Glu Val 
305                 310                 315                 320 


Pro Thr Ala Arg Ser Glu Arg Val Lys Glu Arg Ile Gln Val Arg Phe 
                325                 330                 335     


Lys Gly Asp Glu Leu Gln Asp Ser Trp Phe Lys Leu Gln Cys Asp Arg 
            340                 345                 350         


Arg Gln Leu Pro Ile Phe Arg Gln Phe Val Thr Asp Tyr Leu Cys Gln 
        355                 360                 365             


Lys Gln Ala Pro Asp His Glu Lys Phe Gly Glu Gly Leu Phe Thr Leu 
    370                 375                 380                 


Arg Ser Ala Cys Leu Val Trp Lys Glu Asp Pro Gln Gly Ala Arg Lys 
385                 390                 395                 400 


Arg Lys Lys Arg Arg Lys Gln Gly Ala Cys Gln Asp Glu Pro Trp Glu 
                405                 410                 415     


Thr His Arg Leu Tyr Leu His Cys Thr Ile Asp Thr Arg Phe Leu Thr 
            420                 425                 430         


Gln Glu Gly Thr Glu Gln Val Arg Ala Thr Lys Leu Asp Leu Ala Gln 
        435                 440                 445             


Lys Ala Leu Glu Gly Ile Glu Asn Lys Thr Ala Leu Glu Thr Val Thr 
    450                 455                 460                 


Gln Glu Pro Ser Ala Glu Gln Gln Lys His Leu Lys Arg Lys Gln Thr 
465                 470                 475                 480 


Thr Val His Arg Leu Glu Thr Gln Lys Pro Pro Val Arg Pro Thr Ile 
                485                 490                 495     


Gln Pro Tyr Glu Gly Lys Ser Asn Ile Val Val Gly Val Ser Leu Ser 
            500                 505                 510         


Arg His Glu Pro Val Thr Leu Ile Val Phe Asp Thr Ala Gln 
        515                 520                 525     


<210> 31
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-1 active effector single guide 5' PAM


<220>
<221> modified_base
<222> (3)..(3)
<223> a, c, t, g, unknown or other

<400> 31
gtn                                                                      3


<210> 32
<211> 417
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-3 effector intergenic region encoding tracrRNA

<400> 32
aggttcgtat gtaccactaa aataaatgca gcgcctaagt tcatgtcgtc agcggcctct       60

gtgcttagaa aaagggctag tttgactgtc tgaacgcagt cttgctttct gacctagata      120

actgtccatc cccaaagctg tgagcgcacg cagcaagagg gcacgggttc cggagtgatg      180

gttatcaaat tcacctccga gcaaggagga atccacccaa aacttaaatt tggcaaacct      240

aagcgaggtc aaaaaccctg ggaggtttgc caaaagactg aagctcctgg tctacaaagg      300

tttgagtcat ctagtttgtc ccaatttctg gtctgtcata agaatttagt agaactagat      360

tgggctttgc caaattcaac tctgcaaagc ttgcagggta tgcctttccg atggcaa         417


<210> 33
<211> 468
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-5 effector intergenic region encoding tracrRNA

<400> 33
ctcagcacag atatctgaac cttgaaaaat gaatatctga tatttcttgt gcgcgccggt       60

tctttaggga ctgagcgata agttagggcg agtttaattg ctttccagcc cgtgtagttg      120

tccgctctct tgtgcagctt gctgcatgct aggtgtcggg tcgcgccgac atccaagagg      180

ccatgtttct gtagttagag gctatctctt caattatagg gatacaggtg tacgtgtcgt      240

ggcagctacc aaacagcccc gagcaagggg gcccatccaa attttggcaa acctcagcgc      300

agtcaatatg cccaggcggt ttgccaatct ctcaaatcct tgtgcaatag gtctttcatg      360

caatctcgtc attgagaagc ttcctagagg cgttcggcat ccccaaaata attgaggttt      420

gccaaatacc ccctcgaaaa gactgctgta taagcttttc aagctgcg                   468


<210> 34
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-3 effector target CRISPR repeat

<400> 34
gtcgcccaag gcatttcagg gcagggcgga ttgaaag                                37


<210> 35
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-5 effector target CRISPR repeat

<400> 35
gtttcatccc tgcatttcaa tgcagatggg atgaaag                                37


<210> 36
<211> 105
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 LE 105bp

<400> 36
tgtacattaa cagattattt gtcatcggta acaaattgtt gtcatcttaa caaaatattt       60

gtcatcaata acatattatg tgtcgtgtgc ttattactga aacta                      105


<210> 37
<211> 86
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-1 LE 86bp

<400> 37
tgtacattaa cagattattt gtcatcggta acaaattgtt gtcatcttaa caaaatattt       60

gtcatcaata acatattatg tgtcgt                                            86


<210> 38
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-1 LE 68bp

<400> 38
tgtacattaa cagattattt gtcatcggta acaaattgtt gtcatcttaa caaaatattt       60

gtcatcaa                                                                68


<210> 39
<211> 242
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 RE 242bp

<400> 39
tgtacagtaa ctaattattt gtcgtcttaa caaaatcgtg tcgccgaact atttgagagt       60

gaaagcttta tataatcact gctttagctg aattatagca ttaatctttg acaaaagtta      120

ttgcttacta tattaacaaa ttaactgtca ttttccagta aattaacaga ttaagtgtca      180

tttacccgaa tggcactttt ttagggactg gagcagtatt aacaaattac ttgtctccaa      240

ac                                                                     242


<210> 40
<211> 196
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 RE 196bp

<400> 40
tgtacagtaa ctaattattt gtcgtcttaa caaaatcgtg tcgccgaact atttgagagt       60

gaaagcttta tataatcact gctttagctg aattatagca ttaatctttg acaaaagtta      120

ttgcttacta tattaacaaa ttaactgtca ttttccagta aattaacaga ttaagtgtca      180

tttacccgaa tggcac                                                      196


<210> 41
<211> 178
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 RE 178bp

<400> 41
tgtacagtaa ctaattattt gtcgtcttaa caaaatcgtg tcgccgaact atttgagagt       60

gaaagcttta tataatcact gctttagctg aattatagca ttaatctttg acaaaagtta      120

ttgcttacta tattaacaaa ttaactgtca ttttccagta aattaacaga ttaagtgt        178


<210> 42
<211> 260
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 RE internal deletion 50

<400> 42
tgtacagtaa ctaattattt gtcgtcttaa caaaatcgtg tcgccgaact atttgagagt       60

gaaagaaagt tattgcttac tatattaaca aattaactgt cattttccag taaattaaca      120

gattaagtgt catttacccg aatggcactt ttttagggac tggagcagta ttaacaaatt      180

acttgtctcc aaacttcaag tattacgata caattatatt aaataaacaa ttatgtaata      240

atcagacatt tttgttcatt                                                  260


<210> 43
<211> 231
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 RE internal deletion 81

<400> 43
tgtacagtaa ctaattattt gtcgtcttaa caaaatcgtg tcgccgaact atttattaac       60

aaattaactg tcattttcca gtaaattaac agattaagtg tcatttaccc gaatggcact      120

tttttaggga ctggagcagt attaacaaat tacttgtctc caaacttcaa gtattacgat      180

acaattatat taaataaaca attatgtaat aatcagacat ttttgttcat t               231


<210> 44
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-1 RE internal deletion 81 & 178bp

<400> 44
tgtacagtaa ctaattattt gtcgtcttaa caaaatcgtg tcgccgaact attaacaaat       60

taactgtcat tttccagtaa attaacagat taagtg                                 96


<210> 45
<211> 237
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 1

<400> 45
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta catagggtag gtgcgctccc agcaataagt ggcgtgggtt taccacagtg      180

acggctactg aatcacctcc gaccaaggag gaatccactg aaaagatgga ttgaaag         237


<210> 46
<211> 214
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 2

<400> 46
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctggaaacag caataagtgg cgtgggttta ccacagtgac ggctactgaa tcacctccga      180

ccaaggagga atccactaaa agatggattg aaag                                  214


<210> 47
<211> 170
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 3

<400> 47
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtg aaaacggcta      120

ctgaatcacc tccgaccaag gaggaatcca ctgaaaagat ggattgaaag                 170


<210> 48
<211> 276
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 4

<400> 48
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta caatttaggt tgtagagatg attaacctgt aacttgaggt tagctaataa      180

tttcatttta tagggtaggt gcgctcccag caataagtgg cgtgggttta ccacagtgac      240

ggctactgaa tcacctccga ccaaggagga tgaaag                                276


<210> 49
<211> 281
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 5

<400> 49
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta caatttaggt tgtagagatg attaacctgt aacttgaggt tagctaataa      180

tttcatttta tagggtaggt gcgctcccag caataagtgg cgtgggttta ccacagtgac      240

ggctactgaa tcacgaatcc actgaaaaga tggattgaaa g                          281


<210> 50
<211> 284
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 6

<400> 50
gccgtagatc atgttcttga ttgaacctct gaactacgaa aaatgagggt tagtttgact       60

ctcggcagat agtcttgctt tctgacccta gtggctgtcc accctgatgc tgatttctac      120

aatttaggtt gtagagatga ttaacctgta acttgaggtt agctaataat ttcattttat      180

agggtaggtg cgctcccagc aataagtggc gtgggtttac cacagtgacg gctactgaat      240

cacctccgac caaggaggaa tccactgaaa agatggattg aaag                       284


<210> 51
<211> 283
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 7

<400> 51
aaaataatcg cgccgtagat catgcctctg aactacgaaa aatgagggtt agtttgactc       60

tcggcagata gtcttgcttt ctgaccctag tggctgtcca ccctgatgct gatttctaca      120

atttaggttg tagagatgat taacctgtaa cttgaggtta gctaataatt tcattttata      180

gggtaggtgc gctcccagca ataagtggcg tgggtttacc acagtgacgg ctactgaatc      240

acctccgacc aaggaggaat ccactgaaaa gatggattga aag                        283


<210> 52
<211> 273
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 8

<400> 52
aaaataatcg cgccgtagat aactacgaaa aatgagggtt agtttgactc tcggcagata       60

gtcttgcttt ctgaccctag tggctgtcca ccctgatgct gatttctaca atttaggttg      120

tagagatgat taacctgtaa cttgaggtta gctaataatt tcattttata gggtaggtgc      180

gctcccagca ataagtggcg tgggtttacc acagtgacgg ctactgaatc acctccgacc      240

aaggaggaat ccactgaaaa gatggattga aag                                   273


<210> 53
<211> 263
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 9

<400> 53
aaaataatcg cgccgcgaaa aatgagggtt agtttgactc tcggcagata gtcttgcttt       60

ctgaccctag tggctgtcca ccctgatgct gatttctaca atttaggttg tagagatgat      120

taacctgtaa cttgaggtta gctaataatt tcattttata gggtaggtgc gctcccagca      180

ataagtggcg tgggtttacc acagtgacgg ctactgaatc acctccgacc aaggaggaat      240

ccactgaaaa gatggattga aag                                              263


<210> 54
<211> 278
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 10

<400> 54
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgcggc       60

agatagtctt gctttctgac cctagtggct gtccaccctg atgctgattt ctacaattta      120

ggttgtagag atgattaacc tgtaacttga ggttagctaa taatttcatt ttatagggta      180

ggtgcgctcc cagcaataag tggcgtgggt ttaccacagt gacggctact gaatcacctc      240

cgaccaagga ggaatccact gaaaagatgg attgaaag                              278


<210> 55
<211> 215
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 11

<400> 55
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcgcctag tggctgtcca ccctgatgct gatttctaca tagggtaggt      120

gcgctcccag caataagtgg cgtgggttta ccacagtgac ggctactgaa tcacctccga      180

ccaaggagga atccactgaa aagatggatt gaaag                                 215


<210> 56
<211> 221
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 12

<400> 56
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta catagggtag gtgcgctgtg ggtttaccac agtgacggct actgaatcac      180

ctccgaccaa ggaggaatcc actgaaaaga tggattgaaa g                          221


<210> 57
<211> 226
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 13

<400> 57
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta catagggtag gtgcgctccc agcaataagt ggcgcagtga cggctactga      180

atcacctccg accaaggagg aatccactga aaagatggat tgaaag                     226


<210> 58
<211> 224
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 14

<400> 58
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta catagggtag gtgcgctccc agcaataagt ggcagtgacg gctactgaat      180

cacctccgac caaggaggaa tccactgaaa agatggattg aaag                       224


<210> 59
<211> 204
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 15

<400> 59
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta catagggtag gtgcgctccc agcaataagt ggcgtgggtt taccacagtg      180

acggctactg aatcacgatg aaag                                             204


<210> 60
<211> 181
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 16

<400> 60
gccgtagatc atgcctctga actacgaaaa atgagggtta gtttgactct cggcagatag       60

tcttgctttc tgaccctagt ggctgtccac cctgatgctg atttctacat agggtaggtg      120

cgctcccagc aataagtggc gtgggtttac cacagtgacg gctactgaat cacgatgaaa      180

g                                                                      181


<210> 61
<211> 262
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 17

<400> 61
aaaataatcg cgccgtagat catgttcttg attgaacctc tgaactacga aaaatgaggg       60

ttagtttgac tctcggcaga tagtcttgct ttctgaccct agtggctgtc caccctgatg      120

ctgatttcta caatttaggt tgtagagatg attaacctgt aacttgaggt tagctaataa      180

tttcatttta tagggtaggt gcgctcccag caataagtgg cgtgggttta ccacagtgac      240

ggctactgaa tcacgatgaa ag                                               262


<210> 62
<211> 272
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 18

<400> 62
gccgtagatc atgcctctga actacgaaaa atgagggtta gtttgactct cggcagatag       60

tcttgctttc tgaccctagt ggctgtccac cctgatgctg atttctacaa tttaggttgt      120

agagatgatt aacctgtaac ttgaggttag ctaataattt cattttatag ggtaggtgcg      180

ctcccagcaa taagtggcgt gggtttacca cagtgacggc tactgaatca cctccgacca      240

aggaggaatc cactgaaaag atggattgaa ag                                    272


<210> 63
<211> 251
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 engineered single guide 19

<400> 63
gccgtagatc atgttcttga ttgaacctct gaactacgaa aaatgagggt tagtttgact       60

ctcggcagat agtcttgctt tctgacccta gtggctgtcc accctgatgc tgatttctac      120

aatttaggtt gtagagatga ttaacctgta acttgaggtt agctaataat ttcattttat      180

agggtaggtg cgctcccagc aataagtggc gtgggtttac cacagtgacg gctactgaat      240

cacgatgaaa g                                                           251


<210> 64
<211> 122
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 effector sequence

<220>
<223> MG64-55 effector

<400> 64
Met Ser Gln Ile Thr Val Arg Ala Arg Leu Ile Ala Pro Glu Glu Thr 
1               5                   10                  15      


Arg Arg Ala Tyr Trp Asp Leu Met Ala Ala Ser Asn Thr Pro Leu Ile 
            20                  25                  30          


Asn Glu Ala Leu Arg Ile Leu Pro Thr Leu Pro Asp Phe Pro Lys Trp 
        35                  40                  45              


Arg Gln Lys Gly Asn Leu Pro Asp Lys Ala Ala Glu Asn Leu Ile Ile 
    50                  55                  60                  


Lys Leu Lys Glu Asp Pro Arg Phe Val Gly Gln Leu Phe Trp Ser Tyr 
65                  70                  75                  80  


Ile Ser Ala His Lys Gln Val Thr Tyr Thr Phe Arg Ser Trp Leu Ala 
                85                  90                  95      


Leu Gln His Arg Lys Gln Trp Lys Leu Ala Gly Lys Arg Leu Trp Leu 
            100                 105                 110         


Glu Ile Leu Gln Pro Asp Glu Thr Leu Ala 
        115                 120         


<210> 65
<211> 134
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-55-B transposition protein

<400> 65
Ser Ser Ser Val Ser Lys Gly Thr Met Met Ala Gln Trp Arg Asn Ala 
1               5                   10                  15      


Tyr Thr Ser Ile Leu Lys Leu Ile Asp Arg Gln Ser Leu Lys Ala Lys 
            20                  25                  30          


Ser Val His Leu Gly His Leu His Lys Gly Ile Ser Arg Ala Arg Ser 
        35                  40                  45              


Leu Arg Glu Trp Glu Ala Ala Lys Lys Ala Leu Lys Lys Gln Asn Lys 
    50                  55                  60                  


Asn Leu Thr Ser Gln Asn Val Ser Thr Tyr Phe Glu Asp Glu Glu Arg 
65                  70                  75                  80  


Thr Pro Gln Lys Ser Met Arg Gln Arg Arg Lys Ala Ala Gln Lys Ala 
                85                  90                  95      


Asn Lys Lys Pro Leu Pro Met Ile Glu Asp Asp Leu Gln Glu Glu Ser 
            100                 105                 110         


Asn Leu Glu Asp Glu Lys Asn Pro Leu Leu Asp Leu Glu Val Thr Tyr 
        115                 120                 125             


Asp Asp Asp Leu Phe Glu 
    130                 


<210> 66
<211> 272
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-55-C transposition protein

<400> 66
Met Glu Lys Gln Val Asp Gln Ile Ala Ser Ala Leu Gly Ala Leu Pro 
1               5                   10                  15      


Glu Leu Ser Pro Glu Ile His Lys Glu Leu Glu Arg Leu Ser Lys Arg 
            20                  25                  30          


Pro Tyr Ile Leu Leu Pro Lys Val Glu Ser Cys His Ile Phe Leu Glu 
        35                  40                  45              


Glu Cys Arg Leu Gly Arg Ala His Gly Arg Ile Val Gly Asp Ser Gly 
    50                  55                  60                  


Val Gly Lys Thr Ile Ser Ala Lys Ala Tyr Ser Lys Arg Leu Ala Glu 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Asn Val Ile Tyr Thr Ile Leu Asn Pro Asn Cys 
                85                  90                  95      


Thr Pro Lys Glu Phe Tyr Glu Lys Ile Leu Glu Ala Leu Gly Phe Thr 
            100                 105                 110         


Tyr Thr Lys Gly Ser Ile Lys Phe Leu Arg Asn Arg Ala Cys Gln Val 
        115                 120                 125             


Leu Ser Arg Arg Gln Ile Ser Val Leu Phe Ile Asp Glu Ala Ser Phe 
    130                 135                 140                 


Leu Lys Met Asp Ala Ile Gly Glu Leu Ile Tyr Leu Glu Glu Ser Glu 
145                 150                 155                 160 


Val Val Pro Ser Ile Phe Leu Ile Gly Thr Asp Arg Leu Asp Thr Leu 
                165                 170                 175     


Leu Ser Gly Asn Glu Gln Val Ala Arg Arg Tyr Pro Arg Tyr Gln Tyr 
            180                 185                 190         


Gly Arg Leu His Asp Lys Glu Leu Lys Asp Val Val Asp Leu Trp Glu 
        195                 200                 205             


Gln Lys Val Leu Gln Leu Pro Val Lys Ser Asn Leu Lys Tyr Lys Ala 
    210                 215                 220                 


Lys Leu Asn Val Ile Thr Lys Ala Thr Ser Gly Cys Leu Gly Glu Ile 
225                 230                 235                 240 


Asp Gln Leu Leu Arg Arg Ala Ala Arg Lys Ala Leu Ile Leu Gly Glu 
                245                 250                 255     


Ser Lys Ile Ser Leu Asn Ile Leu Arg Glu Val Ala Gly Gln Phe Glu 
            260                 265                 270         


<210> 67
<211> 169
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      MG64 transposition protein sequence

<220>
<223> MG64-55-Q transposition protein

<400> 67
Met Asn Asp Ala Gln Ala Ala Gln Trp His Phe Lys Pro Glu Pro Phe 
1               5                   10                  15      


Glu Gly Glu Ser Phe Ser His Phe Leu Gly Arg Tyr Cys Ala Val Asn 
            20                  25                  30          


Cys Ile Ala Pro Asn Ile Leu Ala Lys His Ile Glu Ala Gly Ser Val 
        35                  40                  45              


Ala Ile Gly Arg Trp Arg Lys Leu Arg Tyr Asn Pro Ser Pro Ser Glu 
    50                  55                  60                  


Arg His Leu Gln Arg Leu Ala Asp Val Thr Gly Val Ser Gln Glu Arg 
65                  70                  75                  80  


Leu Leu Ala Met Leu Pro Gln Glu Pro Met Gln Ile Gly Thr Ile Arg 
                85                  90                  95      


Leu Cys Ala Ala Cys Tyr Gly Glu Glu Pro Cys His Arg Ile Arg Trp 
            100                 105                 110         


Gln Tyr Lys Ser Thr Gln Phe Cys Asp Arg His Gln Leu Thr Leu Leu 
        115                 120                 125             


Ala Arg Cys Pro Cys Cys Lys Ala Pro Phe Pro Ile Pro Ala Glu Trp 
    130                 135                 140                 


Asp Ala Gly Ile Cys Leu Arg Cys Gly Lys Ala Phe Val Glu Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Lys Ser Val Leu Gly Gln 
                165                 


<210> 68
<211> 239
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 11


<220>
<221> modified_base
<222> (217)..(239)
<223> a, c, u, g, unknown or other

<400> 68
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucgccua guggcugucc acccugaugc ugauuucuac auaggguagg      120

ugcgcuccca gcaauaagug gcguggguuu accacaguga cggcuacuga aucaccuccg      180

accaaggagg aauccacuga aaagauggau ugaaagnnnn nnnnnnnnnn nnnnnnnnn       239


<210> 69
<211> 245
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 12


<220>
<221> modified_base
<222> (223)..(245)
<223> a, c, u, g, unknown or other

<400> 69
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucggcag auagucuugc uuucugaccc uaguggcugu ccacccugau      120

gcugauuucu acauagggua ggugcgcugu ggguuuacca cagugacggc uacugaauca      180

ccuccgacca aggaggaauc cacugaaaag auggauugaa agnnnnnnnn nnnnnnnnnn      240

nnnnn                                                                  245


<210> 70
<211> 250
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 13


<220>
<221> modified_base
<222> (228)..(250)
<223> a, c, u, g, unknown or other

<400> 70
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucggcag auagucuugc uuucugaccc uaguggcugu ccacccugau      120

gcugauuucu acauagggua ggugcgcucc cagcaauaag uggcgcagug acggcuacug      180

aaucaccucc gaccaaggag gaauccacug aaaagaugga uugaaagnnn nnnnnnnnnn      240

nnnnnnnnnn                                                             250


<210> 71
<211> 248
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 14


<220>
<221> modified_base
<222> (226)..(248)
<223> a, c, u, g, unknown or other

<400> 71
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucggcag auagucuugc uuucugaccc uaguggcugu ccacccugau      120

gcugauuucu acauagggua ggugcgcucc cagcaauaag uggcagugac ggcuacugaa      180

ucaccuccga ccaaggagga auccacugaa aagauggauu gaaagnnnnn nnnnnnnnnn      240

nnnnnnnn                                                               248


<210> 72
<211> 263
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA v2-1


<220>
<221> modified_base
<222> (241)..(263)
<223> a, c, u, g, unknown or other

<400> 72
gaauuaauag cgccgccguu caugcuucua ggagccucug aaaggugaca aaugcggguu       60

aguuuggcug uugucagaca gucuugcuuu cugacccugg uagcugccca ccccgaagcu      120

gcuguuccuu gugaacagga auuaggugcg cccccaguaa uaaggguaug gguuuaccac      180

agugguggcu acugaaucac cuccgagcaa ggaggaaccc acugaaaggu ggguugaaag      240

nnnnnnnnnn nnnnnnnnnn nnn                                              263


<210> 73
<211> 262
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 20


<220>
<221> modified_base
<222> (240)..(262)
<223> a, c, u, g, unknown or other

<400> 73
gccguagauc augccucuga acuacgaaaa augaggguua guuugacucu cggcagauag       60

ucuugcuuuc ugacccuagu ggcuguccac ccugaugcug auuucuacaa uuuagguugu      120

agagaugauu aaccuguaac uugagguuag cuaauaauuu cauuuuauag gguaggugcg      180

cucccagcaa uaaguggcgu ggguuuacca cagugacggc uacugaauca cgaugaaagn      240

nnnnnnnnnn nnnnnnnnnn nn                                               262


<210> 74
<211> 241
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-3 effector sgRNA


<220>
<221> modified_base
<222> (219)..(241)
<223> a, c, u, g, unknown or other

<400> 74
gaaauaaaug cagcgccuaa guucaugucg ucagcggccu cugugcuuag aaaaagggcu       60

aguuugacug ucugaacgca gucuugcuuu cugaccuaga uaacugucca uccccaaagc      120

ugugagcgca cgcagcaaga gggcacgggu uccggaguga ugguuaucaa auucaccucc      180

gagcaaggag gaauccaccc gaaagggcgg auugaaagnn nnnnnnnnnn nnnnnnnnnn      240

n                                                                      241


<210> 75
<211> 264
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-5 effector sgRNA


<220>
<221> modified_base
<222> (242)..(264)
<223> a, c, u, g, unknown or other

<400> 75
gcgcgccggu ucuuuaggga cugagcgaua aguuagggcg aguuuaauug cuuuccagcc       60

cguguaguug uccgcucucu ugugcagcuu gcugcaugcu aggugucggg ucgcgccgac      120

auccaagagg ccauguuucu guaguuagag gcuaucucuu caauuauagg gauacaggug      180

uacgugucgu ggcagcuacc aaacagcccc gagcaagggg gcccauccga aaggaugaaa      240

gnnnnnnnnn nnnnnnnnnn nnnn                                             264


<210> 76
<211> 447
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-3 putative transposon end LE

<400> 76
aaggcgagtt tgggaacgga tactcctggg catttctaac tcaacgtggt atcgtcataa       60

atccgagggc gattagcaca gtggtagcgc gcttccttca cacggaagag gtcactggtt      120

cgaacccagt atcgcccata catttgtcga ataacgcttt atttgtcgtc ggtaacacat      180

ttgtgtcgtc cataacgctt agatgtcatc gataacagtt ttttgtcacc ttctcggtaa      240

gtttgccgtt aagcgatcgt tcacacaatg ctgtcgtcca aaattaggct tttgatgtgt      300

gaaggaagcg cgcctttcaa tccacctatg cgtatattaa cgccaaaact tgatccaagt      360

acaaatgttt taagactgta ttctggtctg catgaaaagc tttaggcgtc tagatatgag      420

aagccaccta atctacatgc ggtcgac                                          447


<210> 77
<211> 430
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-3 putative transposon end RE

<400> 77
ggagtcatgc agtacaagtg aattaaatca aatgtactat gactaccaag atatgtcatc       60

taatttgtta gatccgataa agccgccaag aggcgacaaa gagtgtgtta atgccaaggt      120

gatctcagat tccaagagac gacactgatt gtgttcaact tccaagagac gtcagttatt      180

ctgttagtca aagagactca ttgagatatg agtggaaacg ctgaagagtc tgatctgaat      240

tggttctggc tatctcaagc tcgatgacaa gattgcgtta tgacgacatt ttacgtgtta      300

ctcgacaaca gcggctgacg gtggcaccct cagcaatttt ctcttccaca aagtcgggat      360

catctgaccc cgtgacgaag ggccgccagg gacgtatacc atgtcactga ggcagcaaga      420

tagggatcaa                                                             430


<210> 78
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-5 putative transposon end LE

<400> 78
ttgagacgaa ggttgatatc tatcgagccg taactgcttg agctgagttt tcaacctcta       60

agcgcaagaa aaaacgactc gtaattcgcg aaaaacgcac atatgaactt tcgacttccg      120

atttgcgaaa aatgactttg cgactcgcaa tctgcgaatc tgtacttgtt tactgatttc      180

gggttggagt gccaaaactc tctctgggca gggactttac ggattattta caagcgatat      240

taatctgcga atcgcgacat ttaatgtgcg aacgtacacc agatttaaag gattaatttc      300

ccaaaaaaca cggaagaata ggcattttag ccgtcaaacc gctattacag tcggtcaatt      360

gatgttaaat ccgccatttt tgccagattt aaggaattag tttccaaaat cctaggccct      420

agttggatgt tgggtgcgat cgcagcgctc                                       450


<210> 79
<211> 583
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-5 putative transposon end RE

<400> 79
tttagttgtc gcaaagacaa ctgtaaaagt ggtatcacag gtgccctgga atcgtcaaac       60

cctctctatt agatcctttt tgcttgtttt gcggtctgat caggatcaga tttatcgatt      120

ccaagcttgt cataatgaca attaacgaat agcgatatac gtatacgtac atcgacatgt      180

tgatagttgc tcacccacac agtggccgcg agcgacttac cgaaaggctc ctaggtgttt      240

gtgagtggta ttggaaagca gcaaaagcga tcgcaccccc taatggagtc tgccgaaaca      300

ggcgcaaaac aaagatggcg acgattgcag aaacgcctga cagcagcagc cgaggatggg      360

aatactaggc tgctaatgtc gatcgcccac aagtacccaa atgcctgaaa cccacatcac      420

cgttggagcc catcaagatt ttgagactta cctgacggaa cctttcggtg acgggcctgc      480

cagtgatgaa cgtgcggccg actttagaaa taggctgaaa tcagcccaga cgctccaaga      540

tgctggtttg ccaatagtcg aaaatgtttt ggttggtcgc tga                        583


<210> 80
<211> 803
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MG64-1 effector - MG64-1-Q fusion

<400> 80
Met Ser Gln Ile Thr Ile Gln Cys Arg Leu Val Ala Lys Glu Pro Ile 
1               5                   10                  15      


Arg His Thr Leu Trp Gln Leu Met Ala Asp Leu Asn Thr Pro Phe Ile 
            20                  25                  30          


Asn Glu Leu Leu Gln Lys Val Ala Gln His Pro Asp Phe Glu Lys Trp 
        35                  40                  45              


Lys Gln Arg Gly Arg Leu Lys Val Lys Val Ile Glu Gln Leu Gly Asn 
    50                  55                  60                  


Glu Leu Lys Lys Asp Pro Arg Phe Leu Gly Gln Pro Ala Arg Phe Tyr 
65                  70                  75                  80  


Thr Ser Gly Ile Asn Leu Val Lys Tyr Ile Phe Lys Ser Trp Leu Lys 
                85                  90                  95      


Leu Gln Gln Arg Leu Gln Gln Lys Leu Asp Arg Lys Arg Arg Trp Leu 
            100                 105                 110         


Glu Val Leu Lys Ser Asp Asp Gln Leu Ile Lys Asp Gly Gln Thr Asp 
        115                 120                 125             


Leu Glu Thr Ile Arg Gln Lys Ala Thr Glu Ile Leu Gln Ser Tyr Glu 
    130                 135                 140                 


Gly Thr Glu Gln Leu Phe Asn Thr Leu Phe Gln Ala Tyr Asn Ser Glu 
145                 150                 155                 160 


Glu Asp Ile Leu Thr Arg Thr Ala Leu Asn Tyr Leu Leu Lys Asn Arg 
                165                 170                 175     


Cys Lys Leu Pro Gln Lys Pro Glu Asp Ala Lys Lys Phe Ala Lys Arg 
            180                 185                 190         


Arg Arg Gln Val Glu Ile Ala Ile Lys Arg Leu Gln Glu Gln Ile Lys 
        195                 200                 205             


Ala Arg Leu Pro Gln Gly Arg Asp Val Thr Asn Glu Asn Trp Leu Glu 
    210                 215                 220                 


Thr Leu Asn Leu Ala Cys Tyr Thr Asp Pro Glu Asn Ile Glu Glu Ala 
225                 230                 235                 240 


Arg Ser Trp Gln Asp Lys Leu Leu Thr Lys Ser Ser Ser Ile Pro Phe 
                245                 250                 255     


Pro Ile Asn Tyr Glu Thr Asn Glu Asp Leu Ile Trp Ser Lys Asn Glu 
            260                 265                 270         


Lys Gly His Leu Cys Val Gln Phe Asn Gly Ile Ser Asp Leu Lys Phe 
        275                 280                 285             


Lys Ile Tyr Cys Asp Lys Arg Gln Leu Lys Trp Phe Gln Arg Phe Tyr 
    290                 295                 300                 


Glu Asp Gln Gln Ile Lys Lys Ser Asn Asn Asn Gln His Ser Ser Ala 
305                 310                 315                 320 


Leu Phe Thr Leu Arg Ser Gly Arg Ile Leu Trp Gln Glu Asp Lys Gly 
                325                 330                 335     


Lys Gly Gln Leu Trp Asp Ile His Arg Leu Thr Leu Gln Cys Thr Leu 
            340                 345                 350         


Asp Thr Arg Thr Trp Thr Gln Glu Gly Thr Glu Gln Val Lys Glu Glu 
        355                 360                 365             


Lys Ala Asp Glu Ile Ala Gly Ile Leu Thr Arg Met Asn Glu Lys Gly 
    370                 375                 380                 


Asp Leu Thr Lys Asn Gln Gln Ala Phe Ile Gln Arg Lys Gln Ser Thr 
385                 390                 395                 400 


Leu Asp Lys Leu Glu Asn Pro Phe Pro Arg Pro Ser Arg Pro Val Tyr 
                405                 410                 415     


Arg Gly Gln Ser Asn Ile Leu Leu Gly Val Ser Met Glu Leu Lys Lys 
            420                 425                 430         


Pro Ala Thr Ile Ala Val Ile Asp Gly Met Thr Arg Lys Val Leu Thr 
        435                 440                 445             


Tyr Arg Asn Ile Lys Gln Leu Leu Gly Lys Asn Tyr Pro Leu Leu Asn 
    450                 455                 460                 


Arg Gln Arg Arg Gln Lys Gln Leu Gln Ser His Gln Arg Asn Val Ala 
465                 470                 475                 480 


Gln Arg Lys Glu Ala Phe Asn Gln Phe Gly Asp Ser Glu Leu Gly Glu 
                485                 490                 495     


Tyr Ile Asp Arg Leu Leu Ala Lys Ala Ile Ile Ala Ile Ala Lys Gln 
            500                 505                 510         


Tyr Gln Ala Arg Ser Ile Val Val Pro His Leu Lys Asp Ile Arg Glu 
        515                 520                 525             


Ala Ile Gln Ser Glu Ile Gln Ala Leu Ala Glu Ala Lys Ile Pro Asn 
    530                 535                 540                 


Cys Ile Glu Ala Gln Ala Glu Tyr Ala Lys Lys Tyr Arg Ile Gln Val 
545                 550                 555                 560 


His Gln Trp Ser Tyr Gly Arg Leu Ile Asp Asn Ile Gln Ala Gln Ala 
                565                 570                 575     


Ser Lys Leu Gly Ile Val Ile Glu Glu Ser Gln Gln Pro Leu Gln Gly 
            580                 585                 590         


Thr Pro Leu Gln Lys Ala Ala Glu Leu Ala Phe Lys Ala Tyr Gln Ser 
        595                 600                 605             


Arg Leu Ser Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Ser Met Glu Ser Arg Glu Ile Gln Pro 
625                 630                 635                 640 


Trp Trp Phe Leu Val Glu Pro Leu Ala Gly Glu Ser Ile Ser His Phe 
                645                 650                 655     


Leu Gly Arg Phe Arg Arg Glu Asn Glu Leu Thr Val Thr Met Met Gly 
            660                 665                 670         


Lys Ile Thr Gly Leu Gly Gly Thr Ile Thr Arg Trp Glu Lys Phe Arg 
        675                 680                 685             


Phe Ile Pro Ile Pro Thr Glu Glu Glu Leu Thr Ala Leu Ser Glu Val 
    690                 695                 700                 


Val Gln Val Glu Val Glu Arg Leu Trp Gln Met Phe Pro Pro Lys Gly 
705                 710                 715                 720 


Val Gly Met Lys His Gln Pro Ile Arg Leu Cys Gly Ala Cys Tyr Glu 
                725                 730                 735     


Glu Glu Arg Cys His Lys Ile Glu Trp Gln Leu Lys Thr Thr Gln Phe 
            740                 745                 750         


Cys Ser Gln His Gly Leu Thr Leu Leu Ser Glu Cys Pro Asn Cys Gly 
        755                 760                 765             


Ala Arg Phe Gln Phe Pro Ala Leu Trp Val Asn Gly Trp Cys His Arg 
    770                 775                 780                 


Cys Phe Leu Thr Phe Gly Glu Met Val Glu Gly Gln Ser Asn Lys Lys 
785                 790                 795                 800 


Lys Tyr Leu 
            


<210> 81
<211> 803
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MG64-1-Q - MG64-1 effector fusion

<400> 81
Met Glu Ser Arg Glu Ile Gln Pro Trp Trp Phe Leu Val Glu Pro Leu 
1               5                   10                  15      


Ala Gly Glu Ser Ile Ser His Phe Leu Gly Arg Phe Arg Arg Glu Asn 
            20                  25                  30          


Glu Leu Thr Val Thr Met Met Gly Lys Ile Thr Gly Leu Gly Gly Thr 
        35                  40                  45              


Ile Thr Arg Trp Glu Lys Phe Arg Phe Ile Pro Ile Pro Thr Glu Glu 
    50                  55                  60                  


Glu Leu Thr Ala Leu Ser Glu Val Val Gln Val Glu Val Glu Arg Leu 
65                  70                  75                  80  


Trp Gln Met Phe Pro Pro Lys Gly Val Gly Met Lys His Gln Pro Ile 
                85                  90                  95      


Arg Leu Cys Gly Ala Cys Tyr Glu Glu Glu Arg Cys His Lys Ile Glu 
            100                 105                 110         


Trp Gln Leu Lys Thr Thr Gln Phe Cys Ser Gln His Gly Leu Thr Leu 
        115                 120                 125             


Leu Ser Glu Cys Pro Asn Cys Gly Ala Arg Phe Gln Phe Pro Ala Leu 
    130                 135                 140                 


Trp Val Asn Gly Trp Cys His Arg Cys Phe Leu Thr Phe Gly Glu Met 
145                 150                 155                 160 


Val Glu Gly Gln Ser Asn Lys Lys Lys Tyr Leu Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Met 
            180                 185                 190         


Ser Gln Ile Thr Ile Gln Cys Arg Leu Val Ala Lys Glu Pro Ile Arg 
        195                 200                 205             


His Thr Leu Trp Gln Leu Met Ala Asp Leu Asn Thr Pro Phe Ile Asn 
    210                 215                 220                 


Glu Leu Leu Gln Lys Val Ala Gln His Pro Asp Phe Glu Lys Trp Lys 
225                 230                 235                 240 


Gln Arg Gly Arg Leu Lys Val Lys Val Ile Glu Gln Leu Gly Asn Glu 
                245                 250                 255     


Leu Lys Lys Asp Pro Arg Phe Leu Gly Gln Pro Ala Arg Phe Tyr Thr 
            260                 265                 270         


Ser Gly Ile Asn Leu Val Lys Tyr Ile Phe Lys Ser Trp Leu Lys Leu 
        275                 280                 285             


Gln Gln Arg Leu Gln Gln Lys Leu Asp Arg Lys Arg Arg Trp Leu Glu 
    290                 295                 300                 


Val Leu Lys Ser Asp Asp Gln Leu Ile Lys Asp Gly Gln Thr Asp Leu 
305                 310                 315                 320 


Glu Thr Ile Arg Gln Lys Ala Thr Glu Ile Leu Gln Ser Tyr Glu Gly 
                325                 330                 335     


Thr Glu Gln Leu Phe Asn Thr Leu Phe Gln Ala Tyr Asn Ser Glu Glu 
            340                 345                 350         


Asp Ile Leu Thr Arg Thr Ala Leu Asn Tyr Leu Leu Lys Asn Arg Cys 
        355                 360                 365             


Lys Leu Pro Gln Lys Pro Glu Asp Ala Lys Lys Phe Ala Lys Arg Arg 
    370                 375                 380                 


Arg Gln Val Glu Ile Ala Ile Lys Arg Leu Gln Glu Gln Ile Lys Ala 
385                 390                 395                 400 


Arg Leu Pro Gln Gly Arg Asp Val Thr Asn Glu Asn Trp Leu Glu Thr 
                405                 410                 415     


Leu Asn Leu Ala Cys Tyr Thr Asp Pro Glu Asn Ile Glu Glu Ala Arg 
            420                 425                 430         


Ser Trp Gln Asp Lys Leu Leu Thr Lys Ser Ser Ser Ile Pro Phe Pro 
        435                 440                 445             


Ile Asn Tyr Glu Thr Asn Glu Asp Leu Ile Trp Ser Lys Asn Glu Lys 
    450                 455                 460                 


Gly His Leu Cys Val Gln Phe Asn Gly Ile Ser Asp Leu Lys Phe Lys 
465                 470                 475                 480 


Ile Tyr Cys Asp Lys Arg Gln Leu Lys Trp Phe Gln Arg Phe Tyr Glu 
                485                 490                 495     


Asp Gln Gln Ile Lys Lys Ser Asn Asn Asn Gln His Ser Ser Ala Leu 
            500                 505                 510         


Phe Thr Leu Arg Ser Gly Arg Ile Leu Trp Gln Glu Asp Lys Gly Lys 
        515                 520                 525             


Gly Gln Leu Trp Asp Ile His Arg Leu Thr Leu Gln Cys Thr Leu Asp 
    530                 535                 540                 


Thr Arg Thr Trp Thr Gln Glu Gly Thr Glu Gln Val Lys Glu Glu Lys 
545                 550                 555                 560 


Ala Asp Glu Ile Ala Gly Ile Leu Thr Arg Met Asn Glu Lys Gly Asp 
                565                 570                 575     


Leu Thr Lys Asn Gln Gln Ala Phe Ile Gln Arg Lys Gln Ser Thr Leu 
            580                 585                 590         


Asp Lys Leu Glu Asn Pro Phe Pro Arg Pro Ser Arg Pro Val Tyr Arg 
        595                 600                 605             


Gly Gln Ser Asn Ile Leu Leu Gly Val Ser Met Glu Leu Lys Lys Pro 
    610                 615                 620                 


Ala Thr Ile Ala Val Ile Asp Gly Met Thr Arg Lys Val Leu Thr Tyr 
625                 630                 635                 640 


Arg Asn Ile Lys Gln Leu Leu Gly Lys Asn Tyr Pro Leu Leu Asn Arg 
                645                 650                 655     


Gln Arg Arg Gln Lys Gln Leu Gln Ser His Gln Arg Asn Val Ala Gln 
            660                 665                 670         


Arg Lys Glu Ala Phe Asn Gln Phe Gly Asp Ser Glu Leu Gly Glu Tyr 
        675                 680                 685             


Ile Asp Arg Leu Leu Ala Lys Ala Ile Ile Ala Ile Ala Lys Gln Tyr 
    690                 695                 700                 


Gln Ala Arg Ser Ile Val Val Pro His Leu Lys Asp Ile Arg Glu Ala 
705                 710                 715                 720 


Ile Gln Ser Glu Ile Gln Ala Leu Ala Glu Ala Lys Ile Pro Asn Cys 
                725                 730                 735     


Ile Glu Ala Gln Ala Glu Tyr Ala Lys Lys Tyr Arg Ile Gln Val His 
            740                 745                 750         


Gln Trp Ser Tyr Gly Arg Leu Ile Asp Asn Ile Gln Ala Gln Ala Ser 
        755                 760                 765             


Lys Leu Gly Ile Val Ile Glu Glu Ser Gln Gln Pro Leu Gln Gly Thr 
    770                 775                 780                 


Pro Leu Gln Lys Ala Ala Glu Leu Ala Phe Lys Ala Tyr Gln Ser Arg 
785                 790                 795                 800 


Leu Ser Ala 
            


<210> 82
<211> 831
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MG64-1-Q- 48aa Linker- MG64-1 effector fusion

<400> 82
Met Glu Ser Arg Glu Ile Gln Pro Trp Trp Phe Leu Val Glu Pro Leu 
1               5                   10                  15      


Ala Gly Glu Ser Ile Ser His Phe Leu Gly Arg Phe Arg Arg Glu Asn 
            20                  25                  30          


Glu Leu Thr Val Thr Met Met Gly Lys Ile Thr Gly Leu Gly Gly Thr 
        35                  40                  45              


Ile Thr Arg Trp Glu Lys Phe Arg Phe Ile Pro Ile Pro Thr Glu Glu 
    50                  55                  60                  


Glu Leu Thr Ala Leu Ser Glu Val Val Gln Val Glu Val Glu Arg Leu 
65                  70                  75                  80  


Trp Gln Met Phe Pro Pro Lys Gly Val Gly Met Lys His Gln Pro Ile 
                85                  90                  95      


Arg Leu Cys Gly Ala Cys Tyr Glu Glu Glu Arg Cys His Lys Ile Glu 
            100                 105                 110         


Trp Gln Leu Lys Thr Thr Gln Phe Cys Ser Gln His Gly Leu Thr Leu 
        115                 120                 125             


Leu Ser Glu Cys Pro Asn Cys Gly Ala Arg Phe Gln Phe Pro Ala Leu 
    130                 135                 140                 


Trp Val Asn Gly Trp Cys His Arg Cys Phe Leu Thr Phe Gly Glu Met 
145                 150                 155                 160 


Val Glu Gly Gln Ser Asn Lys Lys Lys Tyr Leu Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Met Ser Gln Ile Thr 
    210                 215                 220                 


Ile Gln Cys Arg Leu Val Ala Lys Glu Pro Ile Arg His Thr Leu Trp 
225                 230                 235                 240 


Gln Leu Met Ala Asp Leu Asn Thr Pro Phe Ile Asn Glu Leu Leu Gln 
                245                 250                 255     


Lys Val Ala Gln His Pro Asp Phe Glu Lys Trp Lys Gln Arg Gly Arg 
            260                 265                 270         


Leu Lys Val Lys Val Ile Glu Gln Leu Gly Asn Glu Leu Lys Lys Asp 
        275                 280                 285             


Pro Arg Phe Leu Gly Gln Pro Ala Arg Phe Tyr Thr Ser Gly Ile Asn 
    290                 295                 300                 


Leu Val Lys Tyr Ile Phe Lys Ser Trp Leu Lys Leu Gln Gln Arg Leu 
305                 310                 315                 320 


Gln Gln Lys Leu Asp Arg Lys Arg Arg Trp Leu Glu Val Leu Lys Ser 
                325                 330                 335     


Asp Asp Gln Leu Ile Lys Asp Gly Gln Thr Asp Leu Glu Thr Ile Arg 
            340                 345                 350         


Gln Lys Ala Thr Glu Ile Leu Gln Ser Tyr Glu Gly Thr Glu Gln Leu 
        355                 360                 365             


Phe Asn Thr Leu Phe Gln Ala Tyr Asn Ser Glu Glu Asp Ile Leu Thr 
    370                 375                 380                 


Arg Thr Ala Leu Asn Tyr Leu Leu Lys Asn Arg Cys Lys Leu Pro Gln 
385                 390                 395                 400 


Lys Pro Glu Asp Ala Lys Lys Phe Ala Lys Arg Arg Arg Gln Val Glu 
                405                 410                 415     


Ile Ala Ile Lys Arg Leu Gln Glu Gln Ile Lys Ala Arg Leu Pro Gln 
            420                 425                 430         


Gly Arg Asp Val Thr Asn Glu Asn Trp Leu Glu Thr Leu Asn Leu Ala 
        435                 440                 445             


Cys Tyr Thr Asp Pro Glu Asn Ile Glu Glu Ala Arg Ser Trp Gln Asp 
    450                 455                 460                 


Lys Leu Leu Thr Lys Ser Ser Ser Ile Pro Phe Pro Ile Asn Tyr Glu 
465                 470                 475                 480 


Thr Asn Glu Asp Leu Ile Trp Ser Lys Asn Glu Lys Gly His Leu Cys 
                485                 490                 495     


Val Gln Phe Asn Gly Ile Ser Asp Leu Lys Phe Lys Ile Tyr Cys Asp 
            500                 505                 510         


Lys Arg Gln Leu Lys Trp Phe Gln Arg Phe Tyr Glu Asp Gln Gln Ile 
        515                 520                 525             


Lys Lys Ser Asn Asn Asn Gln His Ser Ser Ala Leu Phe Thr Leu Arg 
    530                 535                 540                 


Ser Gly Arg Ile Leu Trp Gln Glu Asp Lys Gly Lys Gly Gln Leu Trp 
545                 550                 555                 560 


Asp Ile His Arg Leu Thr Leu Gln Cys Thr Leu Asp Thr Arg Thr Trp 
                565                 570                 575     


Thr Gln Glu Gly Thr Glu Gln Val Lys Glu Glu Lys Ala Asp Glu Ile 
            580                 585                 590         


Ala Gly Ile Leu Thr Arg Met Asn Glu Lys Gly Asp Leu Thr Lys Asn 
        595                 600                 605             


Gln Gln Ala Phe Ile Gln Arg Lys Gln Ser Thr Leu Asp Lys Leu Glu 
    610                 615                 620                 


Asn Pro Phe Pro Arg Pro Ser Arg Pro Val Tyr Arg Gly Gln Ser Asn 
625                 630                 635                 640 


Ile Leu Leu Gly Val Ser Met Glu Leu Lys Lys Pro Ala Thr Ile Ala 
                645                 650                 655     


Val Ile Asp Gly Met Thr Arg Lys Val Leu Thr Tyr Arg Asn Ile Lys 
            660                 665                 670         


Gln Leu Leu Gly Lys Asn Tyr Pro Leu Leu Asn Arg Gln Arg Arg Gln 
        675                 680                 685             


Lys Gln Leu Gln Ser His Gln Arg Asn Val Ala Gln Arg Lys Glu Ala 
    690                 695                 700                 


Phe Asn Gln Phe Gly Asp Ser Glu Leu Gly Glu Tyr Ile Asp Arg Leu 
705                 710                 715                 720 


Leu Ala Lys Ala Ile Ile Ala Ile Ala Lys Gln Tyr Gln Ala Arg Ser 
                725                 730                 735     


Ile Val Val Pro His Leu Lys Asp Ile Arg Glu Ala Ile Gln Ser Glu 
            740                 745                 750         


Ile Gln Ala Leu Ala Glu Ala Lys Ile Pro Asn Cys Ile Glu Ala Gln 
        755                 760                 765             


Ala Glu Tyr Ala Lys Lys Tyr Arg Ile Gln Val His Gln Trp Ser Tyr 
    770                 775                 780                 


Gly Arg Leu Ile Asp Asn Ile Gln Ala Gln Ala Ser Lys Leu Gly Ile 
785                 790                 795                 800 


Val Ile Glu Glu Ser Gln Gln Pro Leu Gln Gly Thr Pro Leu Gln Lys 
                805                 810                 815     


Ala Ala Glu Leu Ala Phe Lys Ala Tyr Gln Ser Arg Leu Ser Ala 
            820                 825                 830     


<210> 83
<211> 851
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MG64-1-Q- 68aa Linker- MG64-1 effector fusion

<400> 83
Met Glu Ser Arg Glu Ile Gln Pro Trp Trp Phe Leu Val Glu Pro Leu 
1               5                   10                  15      


Ala Gly Glu Ser Ile Ser His Phe Leu Gly Arg Phe Arg Arg Glu Asn 
            20                  25                  30          


Glu Leu Thr Val Thr Met Met Gly Lys Ile Thr Gly Leu Gly Gly Thr 
        35                  40                  45              


Ile Thr Arg Trp Glu Lys Phe Arg Phe Ile Pro Ile Pro Thr Glu Glu 
    50                  55                  60                  


Glu Leu Thr Ala Leu Ser Glu Val Val Gln Val Glu Val Glu Arg Leu 
65                  70                  75                  80  


Trp Gln Met Phe Pro Pro Lys Gly Val Gly Met Lys His Gln Pro Ile 
                85                  90                  95      


Arg Leu Cys Gly Ala Cys Tyr Glu Glu Glu Arg Cys His Lys Ile Glu 
            100                 105                 110         


Trp Gln Leu Lys Thr Thr Gln Phe Cys Ser Gln His Gly Leu Thr Leu 
        115                 120                 125             


Leu Ser Glu Cys Pro Asn Cys Gly Ala Arg Phe Gln Phe Pro Ala Leu 
    130                 135                 140                 


Trp Val Asn Gly Trp Cys His Arg Cys Phe Leu Thr Phe Gly Glu Met 
145                 150                 155                 160 


Val Glu Gly Gln Ser Asn Lys Lys Lys Tyr Leu Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Met 
225                 230                 235                 240 


Ser Gln Ile Thr Ile Gln Cys Arg Leu Val Ala Lys Glu Pro Ile Arg 
                245                 250                 255     


His Thr Leu Trp Gln Leu Met Ala Asp Leu Asn Thr Pro Phe Ile Asn 
            260                 265                 270         


Glu Leu Leu Gln Lys Val Ala Gln His Pro Asp Phe Glu Lys Trp Lys 
        275                 280                 285             


Gln Arg Gly Arg Leu Lys Val Lys Val Ile Glu Gln Leu Gly Asn Glu 
    290                 295                 300                 


Leu Lys Lys Asp Pro Arg Phe Leu Gly Gln Pro Ala Arg Phe Tyr Thr 
305                 310                 315                 320 


Ser Gly Ile Asn Leu Val Lys Tyr Ile Phe Lys Ser Trp Leu Lys Leu 
                325                 330                 335     


Gln Gln Arg Leu Gln Gln Lys Leu Asp Arg Lys Arg Arg Trp Leu Glu 
            340                 345                 350         


Val Leu Lys Ser Asp Asp Gln Leu Ile Lys Asp Gly Gln Thr Asp Leu 
        355                 360                 365             


Glu Thr Ile Arg Gln Lys Ala Thr Glu Ile Leu Gln Ser Tyr Glu Gly 
    370                 375                 380                 


Thr Glu Gln Leu Phe Asn Thr Leu Phe Gln Ala Tyr Asn Ser Glu Glu 
385                 390                 395                 400 


Asp Ile Leu Thr Arg Thr Ala Leu Asn Tyr Leu Leu Lys Asn Arg Cys 
                405                 410                 415     


Lys Leu Pro Gln Lys Pro Glu Asp Ala Lys Lys Phe Ala Lys Arg Arg 
            420                 425                 430         


Arg Gln Val Glu Ile Ala Ile Lys Arg Leu Gln Glu Gln Ile Lys Ala 
        435                 440                 445             


Arg Leu Pro Gln Gly Arg Asp Val Thr Asn Glu Asn Trp Leu Glu Thr 
    450                 455                 460                 


Leu Asn Leu Ala Cys Tyr Thr Asp Pro Glu Asn Ile Glu Glu Ala Arg 
465                 470                 475                 480 


Ser Trp Gln Asp Lys Leu Leu Thr Lys Ser Ser Ser Ile Pro Phe Pro 
                485                 490                 495     


Ile Asn Tyr Glu Thr Asn Glu Asp Leu Ile Trp Ser Lys Asn Glu Lys 
            500                 505                 510         


Gly His Leu Cys Val Gln Phe Asn Gly Ile Ser Asp Leu Lys Phe Lys 
        515                 520                 525             


Ile Tyr Cys Asp Lys Arg Gln Leu Lys Trp Phe Gln Arg Phe Tyr Glu 
    530                 535                 540                 


Asp Gln Gln Ile Lys Lys Ser Asn Asn Asn Gln His Ser Ser Ala Leu 
545                 550                 555                 560 


Phe Thr Leu Arg Ser Gly Arg Ile Leu Trp Gln Glu Asp Lys Gly Lys 
                565                 570                 575     


Gly Gln Leu Trp Asp Ile His Arg Leu Thr Leu Gln Cys Thr Leu Asp 
            580                 585                 590         


Thr Arg Thr Trp Thr Gln Glu Gly Thr Glu Gln Val Lys Glu Glu Lys 
        595                 600                 605             


Ala Asp Glu Ile Ala Gly Ile Leu Thr Arg Met Asn Glu Lys Gly Asp 
    610                 615                 620                 


Leu Thr Lys Asn Gln Gln Ala Phe Ile Gln Arg Lys Gln Ser Thr Leu 
625                 630                 635                 640 


Asp Lys Leu Glu Asn Pro Phe Pro Arg Pro Ser Arg Pro Val Tyr Arg 
                645                 650                 655     


Gly Gln Ser Asn Ile Leu Leu Gly Val Ser Met Glu Leu Lys Lys Pro 
            660                 665                 670         


Ala Thr Ile Ala Val Ile Asp Gly Met Thr Arg Lys Val Leu Thr Tyr 
        675                 680                 685             


Arg Asn Ile Lys Gln Leu Leu Gly Lys Asn Tyr Pro Leu Leu Asn Arg 
    690                 695                 700                 


Gln Arg Arg Gln Lys Gln Leu Gln Ser His Gln Arg Asn Val Ala Gln 
705                 710                 715                 720 


Arg Lys Glu Ala Phe Asn Gln Phe Gly Asp Ser Glu Leu Gly Glu Tyr 
                725                 730                 735     


Ile Asp Arg Leu Leu Ala Lys Ala Ile Ile Ala Ile Ala Lys Gln Tyr 
            740                 745                 750         


Gln Ala Arg Ser Ile Val Val Pro His Leu Lys Asp Ile Arg Glu Ala 
        755                 760                 765             


Ile Gln Ser Glu Ile Gln Ala Leu Ala Glu Ala Lys Ile Pro Asn Cys 
    770                 775                 780                 


Ile Glu Ala Gln Ala Glu Tyr Ala Lys Lys Tyr Arg Ile Gln Val His 
785                 790                 795                 800 


Gln Trp Ser Tyr Gly Arg Leu Ile Asp Asn Ile Gln Ala Gln Ala Ser 
                805                 810                 815     


Lys Leu Gly Ile Val Ile Glu Glu Ser Gln Gln Pro Leu Gln Gly Thr 
            820                 825                 830         


Pro Leu Gln Lys Ala Ala Glu Leu Ala Phe Lys Ala Tyr Gln Ser Arg 
        835                 840                 845             


Leu Ser Ala 
    850     


<210> 84
<211> 855
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MG64-1-Q- 72aa Linker- MG64-1 effector fusion

<400> 84
Met Glu Ser Arg Glu Ile Gln Pro Trp Trp Phe Leu Val Glu Pro Leu 
1               5                   10                  15      


Ala Gly Glu Ser Ile Ser His Phe Leu Gly Arg Phe Arg Arg Glu Asn 
            20                  25                  30          


Glu Leu Thr Val Thr Met Met Gly Lys Ile Thr Gly Leu Gly Gly Thr 
        35                  40                  45              


Ile Thr Arg Trp Glu Lys Phe Arg Phe Ile Pro Ile Pro Thr Glu Glu 
    50                  55                  60                  


Glu Leu Thr Ala Leu Ser Glu Val Val Gln Val Glu Val Glu Arg Leu 
65                  70                  75                  80  


Trp Gln Met Phe Pro Pro Lys Gly Val Gly Met Lys His Gln Pro Ile 
                85                  90                  95      


Arg Leu Cys Gly Ala Cys Tyr Glu Glu Glu Arg Cys His Lys Ile Glu 
            100                 105                 110         


Trp Gln Leu Lys Thr Thr Gln Phe Cys Ser Gln His Gly Leu Thr Leu 
        115                 120                 125             


Leu Ser Glu Cys Pro Asn Cys Gly Ala Arg Phe Gln Phe Pro Ala Leu 
    130                 135                 140                 


Trp Val Asn Gly Trp Cys His Arg Cys Phe Leu Thr Phe Gly Glu Met 
145                 150                 155                 160 


Val Glu Gly Gln Ser Asn Lys Lys Lys Tyr Leu Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        195                 200                 205             


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Gly Ser Met Ser Gln Ile Thr Ile Gln Cys Arg Leu Val Ala Lys 
                245                 250                 255     


Glu Pro Ile Arg His Thr Leu Trp Gln Leu Met Ala Asp Leu Asn Thr 
            260                 265                 270         


Pro Phe Ile Asn Glu Leu Leu Gln Lys Val Ala Gln His Pro Asp Phe 
        275                 280                 285             


Glu Lys Trp Lys Gln Arg Gly Arg Leu Lys Val Lys Val Ile Glu Gln 
    290                 295                 300                 


Leu Gly Asn Glu Leu Lys Lys Asp Pro Arg Phe Leu Gly Gln Pro Ala 
305                 310                 315                 320 


Arg Phe Tyr Thr Ser Gly Ile Asn Leu Val Lys Tyr Ile Phe Lys Ser 
                325                 330                 335     


Trp Leu Lys Leu Gln Gln Arg Leu Gln Gln Lys Leu Asp Arg Lys Arg 
            340                 345                 350         


Arg Trp Leu Glu Val Leu Lys Ser Asp Asp Gln Leu Ile Lys Asp Gly 
        355                 360                 365             


Gln Thr Asp Leu Glu Thr Ile Arg Gln Lys Ala Thr Glu Ile Leu Gln 
    370                 375                 380                 


Ser Tyr Glu Gly Thr Glu Gln Leu Phe Asn Thr Leu Phe Gln Ala Tyr 
385                 390                 395                 400 


Asn Ser Glu Glu Asp Ile Leu Thr Arg Thr Ala Leu Asn Tyr Leu Leu 
                405                 410                 415     


Lys Asn Arg Cys Lys Leu Pro Gln Lys Pro Glu Asp Ala Lys Lys Phe 
            420                 425                 430         


Ala Lys Arg Arg Arg Gln Val Glu Ile Ala Ile Lys Arg Leu Gln Glu 
        435                 440                 445             


Gln Ile Lys Ala Arg Leu Pro Gln Gly Arg Asp Val Thr Asn Glu Asn 
    450                 455                 460                 


Trp Leu Glu Thr Leu Asn Leu Ala Cys Tyr Thr Asp Pro Glu Asn Ile 
465                 470                 475                 480 


Glu Glu Ala Arg Ser Trp Gln Asp Lys Leu Leu Thr Lys Ser Ser Ser 
                485                 490                 495     


Ile Pro Phe Pro Ile Asn Tyr Glu Thr Asn Glu Asp Leu Ile Trp Ser 
            500                 505                 510         


Lys Asn Glu Lys Gly His Leu Cys Val Gln Phe Asn Gly Ile Ser Asp 
        515                 520                 525             


Leu Lys Phe Lys Ile Tyr Cys Asp Lys Arg Gln Leu Lys Trp Phe Gln 
    530                 535                 540                 


Arg Phe Tyr Glu Asp Gln Gln Ile Lys Lys Ser Asn Asn Asn Gln His 
545                 550                 555                 560 


Ser Ser Ala Leu Phe Thr Leu Arg Ser Gly Arg Ile Leu Trp Gln Glu 
                565                 570                 575     


Asp Lys Gly Lys Gly Gln Leu Trp Asp Ile His Arg Leu Thr Leu Gln 
            580                 585                 590         


Cys Thr Leu Asp Thr Arg Thr Trp Thr Gln Glu Gly Thr Glu Gln Val 
        595                 600                 605             


Lys Glu Glu Lys Ala Asp Glu Ile Ala Gly Ile Leu Thr Arg Met Asn 
    610                 615                 620                 


Glu Lys Gly Asp Leu Thr Lys Asn Gln Gln Ala Phe Ile Gln Arg Lys 
625                 630                 635                 640 


Gln Ser Thr Leu Asp Lys Leu Glu Asn Pro Phe Pro Arg Pro Ser Arg 
                645                 650                 655     


Pro Val Tyr Arg Gly Gln Ser Asn Ile Leu Leu Gly Val Ser Met Glu 
            660                 665                 670         


Leu Lys Lys Pro Ala Thr Ile Ala Val Ile Asp Gly Met Thr Arg Lys 
        675                 680                 685             


Val Leu Thr Tyr Arg Asn Ile Lys Gln Leu Leu Gly Lys Asn Tyr Pro 
    690                 695                 700                 


Leu Leu Asn Arg Gln Arg Arg Gln Lys Gln Leu Gln Ser His Gln Arg 
705                 710                 715                 720 


Asn Val Ala Gln Arg Lys Glu Ala Phe Asn Gln Phe Gly Asp Ser Glu 
                725                 730                 735     


Leu Gly Glu Tyr Ile Asp Arg Leu Leu Ala Lys Ala Ile Ile Ala Ile 
            740                 745                 750         


Ala Lys Gln Tyr Gln Ala Arg Ser Ile Val Val Pro His Leu Lys Asp 
        755                 760                 765             


Ile Arg Glu Ala Ile Gln Ser Glu Ile Gln Ala Leu Ala Glu Ala Lys 
    770                 775                 780                 


Ile Pro Asn Cys Ile Glu Ala Gln Ala Glu Tyr Ala Lys Lys Tyr Arg 
785                 790                 795                 800 


Ile Gln Val His Gln Trp Ser Tyr Gly Arg Leu Ile Asp Asn Ile Gln 
                805                 810                 815     


Ala Gln Ala Ser Lys Leu Gly Ile Val Ile Glu Glu Ser Gln Gln Pro 
            820                 825                 830         


Leu Gln Gly Thr Pro Leu Gln Lys Ala Ala Glu Leu Ala Phe Lys Ala 
        835                 840                 845             


Tyr Gln Ser Arg Leu Ser Ala 
    850                 855 


<210> 85
<211> 860
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<223> MG64-1-Q- 77aa Linker- MG64-1 effector fusion

<400> 85
Met Glu Ser Arg Glu Ile Gln Pro Trp Trp Phe Leu Val Glu Pro Leu 
1               5                   10                  15      


Ala Gly Glu Ser Ile Ser His Phe Leu Gly Arg Phe Arg Arg Glu Asn 
            20                  25                  30          


Glu Leu Thr Val Thr Met Met Gly Lys Ile Thr Gly Leu Gly Gly Thr 
        35                  40                  45              


Ile Thr Arg Trp Glu Lys Phe Arg Phe Ile Pro Ile Pro Thr Glu Glu 
    50                  55                  60                  


Glu Leu Thr Ala Leu Ser Glu Val Val Gln Val Glu Val Glu Arg Leu 
65                  70                  75                  80  


Trp Gln Met Phe Pro Pro Lys Gly Val Gly Met Lys His Gln Pro Ile 
                85                  90                  95      


Arg Leu Cys Gly Ala Cys Tyr Glu Glu Glu Arg Cys His Lys Ile Glu 
            100                 105                 110         


Trp Gln Leu Lys Thr Thr Gln Phe Cys Ser Gln His Gly Leu Thr Leu 
        115                 120                 125             


Leu Ser Glu Cys Pro Asn Cys Gly Ala Arg Phe Gln Phe Pro Ala Leu 
    130                 135                 140                 


Trp Val Asn Gly Trp Cys His Arg Cys Phe Leu Thr Phe Gly Glu Met 
145                 150                 155                 160 


Val Glu Gly Gln Ser Asn Lys Lys Lys Tyr Leu Gly Thr Lys Tyr Leu 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Ser Met Ser Gln Ile Thr Ile Gln Cys 
                245                 250                 255     


Arg Leu Val Ala Lys Glu Pro Ile Arg His Thr Leu Trp Gln Leu Met 
            260                 265                 270         


Ala Asp Leu Asn Thr Pro Phe Ile Asn Glu Leu Leu Gln Lys Val Ala 
        275                 280                 285             


Gln His Pro Asp Phe Glu Lys Trp Lys Gln Arg Gly Arg Leu Lys Val 
    290                 295                 300                 


Lys Val Ile Glu Gln Leu Gly Asn Glu Leu Lys Lys Asp Pro Arg Phe 
305                 310                 315                 320 


Leu Gly Gln Pro Ala Arg Phe Tyr Thr Ser Gly Ile Asn Leu Val Lys 
                325                 330                 335     


Tyr Ile Phe Lys Ser Trp Leu Lys Leu Gln Gln Arg Leu Gln Gln Lys 
            340                 345                 350         


Leu Asp Arg Lys Arg Arg Trp Leu Glu Val Leu Lys Ser Asp Asp Gln 
        355                 360                 365             


Leu Ile Lys Asp Gly Gln Thr Asp Leu Glu Thr Ile Arg Gln Lys Ala 
    370                 375                 380                 


Thr Glu Ile Leu Gln Ser Tyr Glu Gly Thr Glu Gln Leu Phe Asn Thr 
385                 390                 395                 400 


Leu Phe Gln Ala Tyr Asn Ser Glu Glu Asp Ile Leu Thr Arg Thr Ala 
                405                 410                 415     


Leu Asn Tyr Leu Leu Lys Asn Arg Cys Lys Leu Pro Gln Lys Pro Glu 
            420                 425                 430         


Asp Ala Lys Lys Phe Ala Lys Arg Arg Arg Gln Val Glu Ile Ala Ile 
        435                 440                 445             


Lys Arg Leu Gln Glu Gln Ile Lys Ala Arg Leu Pro Gln Gly Arg Asp 
    450                 455                 460                 


Val Thr Asn Glu Asn Trp Leu Glu Thr Leu Asn Leu Ala Cys Tyr Thr 
465                 470                 475                 480 


Asp Pro Glu Asn Ile Glu Glu Ala Arg Ser Trp Gln Asp Lys Leu Leu 
                485                 490                 495     


Thr Lys Ser Ser Ser Ile Pro Phe Pro Ile Asn Tyr Glu Thr Asn Glu 
            500                 505                 510         


Asp Leu Ile Trp Ser Lys Asn Glu Lys Gly His Leu Cys Val Gln Phe 
        515                 520                 525             


Asn Gly Ile Ser Asp Leu Lys Phe Lys Ile Tyr Cys Asp Lys Arg Gln 
    530                 535                 540                 


Leu Lys Trp Phe Gln Arg Phe Tyr Glu Asp Gln Gln Ile Lys Lys Ser 
545                 550                 555                 560 


Asn Asn Asn Gln His Ser Ser Ala Leu Phe Thr Leu Arg Ser Gly Arg 
                565                 570                 575     


Ile Leu Trp Gln Glu Asp Lys Gly Lys Gly Gln Leu Trp Asp Ile His 
            580                 585                 590         


Arg Leu Thr Leu Gln Cys Thr Leu Asp Thr Arg Thr Trp Thr Gln Glu 
        595                 600                 605             


Gly Thr Glu Gln Val Lys Glu Glu Lys Ala Asp Glu Ile Ala Gly Ile 
    610                 615                 620                 


Leu Thr Arg Met Asn Glu Lys Gly Asp Leu Thr Lys Asn Gln Gln Ala 
625                 630                 635                 640 


Phe Ile Gln Arg Lys Gln Ser Thr Leu Asp Lys Leu Glu Asn Pro Phe 
                645                 650                 655     


Pro Arg Pro Ser Arg Pro Val Tyr Arg Gly Gln Ser Asn Ile Leu Leu 
            660                 665                 670         


Gly Val Ser Met Glu Leu Lys Lys Pro Ala Thr Ile Ala Val Ile Asp 
        675                 680                 685             


Gly Met Thr Arg Lys Val Leu Thr Tyr Arg Asn Ile Lys Gln Leu Leu 
    690                 695                 700                 


Gly Lys Asn Tyr Pro Leu Leu Asn Arg Gln Arg Arg Gln Lys Gln Leu 
705                 710                 715                 720 


Gln Ser His Gln Arg Asn Val Ala Gln Arg Lys Glu Ala Phe Asn Gln 
                725                 730                 735     


Phe Gly Asp Ser Glu Leu Gly Glu Tyr Ile Asp Arg Leu Leu Ala Lys 
            740                 745                 750         


Ala Ile Ile Ala Ile Ala Lys Gln Tyr Gln Ala Arg Ser Ile Val Val 
        755                 760                 765             


Pro His Leu Lys Asp Ile Arg Glu Ala Ile Gln Ser Glu Ile Gln Ala 
    770                 775                 780                 


Leu Ala Glu Ala Lys Ile Pro Asn Cys Ile Glu Ala Gln Ala Glu Tyr 
785                 790                 795                 800 


Ala Lys Lys Tyr Arg Ile Gln Val His Gln Trp Ser Tyr Gly Arg Leu 
                805                 810                 815     


Ile Asp Asn Ile Gln Ala Gln Ala Ser Lys Leu Gly Ile Val Ile Glu 
            820                 825                 830         


Glu Ser Gln Gln Pro Leu Gln Gly Thr Pro Leu Gln Lys Ala Ala Glu 
        835                 840                 845             


Leu Ala Phe Lys Ala Tyr Gln Ser Arg Leu Ser Ala 
    850                 855                 860 


<210> 86
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Nucleoplasmin NLS

<400> 86
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 87
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> SV40 2x NLS

<400> 87
Pro Lys Lys Lys Arg Lys Val Asp Gly Ser Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val Asp Ser 
            


<210> 88
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> P2A

<400> 88
Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 89
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> T2A

<400> 89
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 90
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> HA

<400> 90
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210> 91
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> Myc

<400> 91
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210> 92
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<220>
<223> FLAG

<400> 92
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 93
<211> 486
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active transposon end LE

<400> 93
ctggctaatg cacccagtaa ggcagcggta tcatcaacgg ggtctgacgc tcagtggaac       60

gaaaactcac gttaggctct cttaaggaaa tctatgtaag tttgttgggt tagttgcgtt      120

ttcagtaaat actgtgttat agtaagaact tgtgcggacg tatagctcag ttggttagag      180

tacatcgttg acatcgatgg ggtcactggt tcgagtccag ttacgtccat atttttttga      240

agtgtgtata atattaacta tgtgacttta tgtacattaa cagattattt gtcatcggta      300

acaaattgtt gtcatcttaa caaaatattt gtcatcaata acatattatg tgtcgtgtgc      360

ttattactga aactaatcct agacgatggt aaaaaataga acacatttcc ccgaaaagtg      420

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc      480

acgagg                                                                 486


<210> 94
<211> 199
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-3 effector putative tracrRNA

<400> 94
tgcagcgcct aagttcatgt cgtcagcggc ctctgtgctt agaaaaaggg ctagtttgac       60

tgtctgaacg cagtcttgct ttctgaccta gataactgtc catccccaaa gctgtgagcg      120

cacgcagcaa gagggcacgg gttccggagt gatggttatc aaattcacct ccgagcaagg      180

aggaatccac ccaaaactt                                                   199


<210> 95
<211> 237
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-5 effector putative tracrRNA

<400> 95
tcttgtgcgc gccggttctt tagggactga gcgataagtt agggcgagtt taattgcttt       60

ccagcccgtg tagttgtccg ctctcttgtg cagcttgctg catgctaggt gtcgggtcgc      120

gccgacatcc aagaggccat gtttctgtag ttagaggcta tctcttcaat tatagggata      180

caggtgtacg tgtcgtggca gctaccaaac agccccgagc aagggggccc atccaaa         237


<210> 96
<211> 239
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 11


<220>
<221> modified_base
<222> (217)..(239)
<223> a, c, u, g, unknown or other

<400> 96
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucgccua guggcugucc acccugaugc ugauuucuac auaggguagg      120

ugcgcuccca gcaauaagug gcguggguuu accacaguga cggcuacuga aucaccuccg      180

accaaggagg aauccacuga aaagauggau ugaaagnnnn nnnnnnnnnn nnnnnnnnn       239


<210> 97
<211> 245
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 12


<220>
<221> modified_base
<222> (223)..(245)
<223> a, c, u, g, unknown or other

<400> 97
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucggcag auagucuugc uuucugaccc uaguggcugu ccacccugau      120

gcugauuucu acauagggua ggugcgcugu ggguuuacca cagugacggc uacugaauca      180

ccuccgacca aggaggaauc cacugaaaag auggauugaa agnnnnnnnn nnnnnnnnnn      240

nnnnn                                                                  245


<210> 98
<211> 250
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 13


<220>
<221> modified_base
<222> (228)..(250)
<223> a, c, u, g, unknown or other

<400> 98
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucggcag auagucuugc uuucugaccc uaguggcugu ccacccugau      120

gcugauuucu acauagggua ggugcgcucc cagcaauaag uggcgcagug acggcuacug      180

aaucaccucc gaccaaggag gaauccacug aaaagaugga uugaaagnnn nnnnnnnnnn      240

nnnnnnnnnn                                                             250


<210> 99
<211> 248
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 14


<220>
<221> modified_base
<222> (226)..(248)
<223> a, c, u, g, unknown or other

<400> 99
gaaaauaauc gcgccguaga ucauguucuu gauugaaccu cugaacuacg aaaaaugagg       60

guuaguuuga cucucggcag auagucuugc uuucugaccc uaguggcugu ccacccugau      120

gcugauuucu acauagggua ggugcgcucc cagcaauaag uggcagugac ggcuacugaa      180

ucaccuccga ccaaggagga auccacugaa aagauggauu gaaagnnnnn nnnnnnnnnn      240

nnnnnnnn                                                               248


<210> 100
<211> 263
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA v2-1


<220>
<221> modified_base
<222> (241)..(263)
<223> a, c, u, g, unknown or other

<400> 100
gaauuaauag cgccgccguu caugcuucua ggagccucug aaaggugaca aaugcggguu       60

aguuuggcug uugucagaca gucuugcuuu cugacccugg uagcugccca ccccgaagcu      120

gcuguuccuu gugaacagga auuaggugcg cccccaguaa uaaggguaug gguuuaccac      180

agugguggcu acugaaucac cuccgagcaa ggaggaaccc acugaaaggu ggguugaaag      240

nnnnnnnnnn nnnnnnnnnn nnn                                              263


<210> 101
<211> 262
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-1 active effector engineered sgRNA 20


<220>
<221> modified_base
<222> (240)..(262)
<223> a, c, u, g, unknown or other

<400> 101
gccguagauc augccucuga acuacgaaaa augaggguua guuugacucu cggcagauag       60

ucuugcuuuc ugacccuagu ggcuguccac ccugaugcug auuucuacaa uuuagguugu      120

agagaugauu aaccuguaac uugagguuag cuaauaauuu cauuuuauag gguaggugcg      180

cucccagcaa uaaguggcgu ggguuuacca cagugacggc uacugaauca cgaugaaagn      240

nnnnnnnnnn nnnnnnnnnn nn                                               262


<210> 102
<211> 241
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-3 effector sgRNA


<220>
<221> modified_base
<222> (219)..(241)
<223> a, c, u, g, unknown or other

<400> 102
gaaauaaaug cagcgccuaa guucaugucg ucagcggccu cugugcuuag aaaaagggcu       60

aguuugacug ucugaacgca gucuugcuuu cugaccuaga uaacugucca uccccaaagc      120

ugugagcgca cgcagcaaga gggcacgggu uccggaguga ugguuaucaa auucaccucc      180

gagcaaggag gaauccaccc gaaagggcgg auugaaagnn nnnnnnnnnn nnnnnnnnnn      240

n                                                                      241


<210> 103
<211> 264
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-5 effector sgRNA


<220>
<221> modified_base
<222> (242)..(264)
<223> a, c, u, g, unknown or other

<400> 103
gcgcgccggu ucuuuaggga cugagcgaua aguuagggcg aguuuaauug cuuuccagcc       60

cguguaguug uccgcucucu ugugcagcuu gcugcaugcu aggugucggg ucgcgccgac      120

auccaagagg ccauguuucu guaguuagag gcuaucucuu caauuauagg gauacaggug      180

uacgugucgu ggcagcuacc aaacagcccc gagcaagggg gcccauccga aaggaugaaa      240

gnnnnnnnnn nnnnnnnnnn nnnn                                             264


<210> 104
<211> 199
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-3 effector putative tracrRNA sequence

<400> 104
ugcagcgccu aaguucaugu cgucagcggc cucugugcuu agaaaaaggg cuaguuugac       60

ugucugaacg cagucuugcu uucugaccua gauaacuguc cauccccaaa gcugugagcg      120

cacgcagcaa gagggcacgg guuccggagu gaugguuauc aaauucaccu ccgagcaagg      180

aggaauccac ccaaaacuu                                                   199


<210> 105
<211> 237
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> MG64-5 effector putative tracrRNA sequence

<400> 105
ucuugugcgc gccgguucuu uagggacuga gcgauaaguu agggcgaguu uaauugcuuu       60

ccagcccgug uaguuguccg cucucuugug cagcuugcug caugcuaggu gucgggucgc      120

gccgacaucc aagaggccau guuucuguag uuagaggcua ucucuucaau uauagggaua      180

cagguguacg ugucguggca gcuaccaaac agccccgagc aagggggccc auccaaa         237


<210> 106
<211> 38
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-1 active effector's crRNA sequence

<400> 106
cgucacaauc uauuuugguu aaugagaugg auugaaag                               38


<210> 107
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-3 effector crRNA sequence

<400> 107
gucgcccaag gcauuucagg gcagggcgga uugaaag                                37


<210> 108
<211> 37
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> MG64-5 effector crRNA sequence

<400> 108
guuucauccc ugcauuucaa ugcagauggg augaaag                                37


