                         SEQUENCE LISTING

<110>  Mayo Foundation for Medical Education and Research
 
<120>  METHODS AND MATERIALS FOR TREATING CANCER

<130>  07039-1998WO1

<150>  US 63/082,297
<151>  2020-09-23

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Phe Asp Ser Asn Leu Leu His 
1               5                   


<210>  2
<211>  767
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Phe Asp Pro Asn Leu Leu His Asn Asn Gly His Asn Gly Tyr 
1               5                   10                  15      


Pro Asn Gly Thr Ser Ala Ala Leu Arg Glu Thr Gly Val Ile Glu Lys 
            20                  25                  30          


Leu Leu Thr Ser Tyr Gly Phe Ile Gln Cys Ser Glu Arg Gln Ala Arg 
        35                  40                  45              


Leu Phe Phe His Cys Ser Gln Tyr Asn Gly Asn Leu Gln Asp Leu Lys 
    50                  55                  60                  


Val Gly Asp Asp Val Glu Phe Glu Val Ser Ser Asp Arg Arg Thr Gly 
65                  70                  75                  80  


Lys Pro Ile Ala Val Lys Leu Val Lys Ile Lys Gln Glu Ile Leu Pro 
                85                  90                  95      


Glu Glu Arg Met Asn Gly Gln Glu Val Phe Tyr Leu Thr Tyr Thr Pro 
            100                 105                 110         


Glu Asp Val Glu Gly Asn Val Gln Leu Glu Thr Gly Asp Lys Ile Asn 
        115                 120                 125             


Phe Val Ile Asp Asn Asn Lys His Thr Gly Ala Val Ser Ala Arg Asn 
    130                 135                 140                 


Ile Met Leu Leu Lys Lys Lys Gln Ala Arg Cys Gln Gly Val Val Cys 
145                 150                 155                 160 


Ala Met Lys Glu Ala Phe Gly Phe Ile Glu Arg Gly Asp Val Val Lys 
                165                 170                 175     


Glu Ile Phe Phe His Tyr Ser Glu Phe Lys Gly Asp Leu Glu Thr Leu 
            180                 185                 190         


Gln Pro Gly Asp Asp Val Glu Phe Thr Ile Lys Asp Arg Asn Gly Lys 
        195                 200                 205             


Glu Val Ala Thr Asp Val Arg Leu Leu Pro Gln Gly Thr Val Ile Phe 
    210                 215                 220                 


Glu Asp Ile Ser Ile Glu His Phe Glu Gly Thr Val Thr Lys Val Ile 
225                 230                 235                 240 


Pro Lys Val Pro Ser Lys Asn Gln Asn Asp Pro Leu Pro Gly Arg Ile 
                245                 250                 255     


Lys Val Asp Phe Val Ile Pro Lys Glu Leu Pro Phe Gly Asp Lys Asp 
            260                 265                 270         


Thr Lys Ser Lys Val Thr Leu Leu Glu Gly Asp His Val Arg Phe Asn 
        275                 280                 285             


Ile Ser Thr Asp Arg Arg Asp Lys Leu Glu Arg Ala Thr Asn Ile Glu 
    290                 295                 300                 


Val Leu Ser Asn Thr Phe Gln Phe Thr Asn Glu Ala Arg Glu Met Gly 
305                 310                 315                 320 


Val Ile Ala Ala Met Arg Asp Gly Phe Gly Phe Ile Lys Cys Val Asp 
                325                 330                 335     


Arg Asp Val Arg Met Phe Phe His Phe Ser Glu Ile Leu Asp Gly Asn 
            340                 345                 350         


Gln Leu His Ile Ala Asp Glu Val Glu Phe Thr Val Val Pro Asp Met 
        355                 360                 365             


Leu Ser Ala Gln Arg Asn His Ala Ile Arg Ile Lys Lys Leu Pro Lys 
    370                 375                 380                 


Gly Thr Val Ser Phe His Ser His Ser Asp His Arg Phe Leu Gly Thr 
385                 390                 395                 400 


Val Glu Lys Glu Ala Thr Phe Ser Asn Pro Lys Thr Thr Ser Pro Asn 
                405                 410                 415     


Lys Gly Lys Glu Lys Glu Ala Glu Asp Gly Ile Ile Ala Tyr Asp Asp 
            420                 425                 430         


Cys Gly Val Lys Leu Thr Ile Ala Phe Gln Ala Lys Asp Val Glu Gly 
        435                 440                 445             


Ser Thr Ser Pro Gln Ile Gly Asp Lys Val Glu Phe Ser Ile Ser Asp 
    450                 455                 460                 


Lys Gln Arg Pro Gly Gln Gln Val Ala Thr Cys Val Arg Leu Leu Gly 
465                 470                 475                 480 


Arg Asn Ser Asn Ser Lys Arg Leu Leu Gly Tyr Val Ala Thr Leu Lys 
                485                 490                 495     


Asp Asn Phe Gly Phe Ile Glu Thr Ala Asn His Asp Lys Glu Ile Phe 
            500                 505                 510         


Phe His Tyr Ser Glu Phe Ser Gly Asp Val Asp Ser Leu Glu Leu Gly 
        515                 520                 525             


Asp Met Val Glu Tyr Ser Leu Ser Lys Gly Lys Gly Asn Lys Val Ser 
    530                 535                 540                 


Ala Glu Lys Val Asn Lys Thr His Ser Val Asn Gly Ile Thr Glu Glu 
545                 550                 555                 560 


Ala Asp Pro Thr Ile Tyr Ser Gly Lys Val Ile Arg Pro Leu Arg Ser 
                565                 570                 575     


Val Asp Pro Thr Gln Thr Glu Tyr Gln Gly Met Ile Glu Ile Val Glu 
            580                 585                 590         


Glu Gly Asp Met Lys Gly Glu Val Tyr Pro Phe Gly Ile Val Gly Met 
        595                 600                 605             


Ala Asn Lys Gly Asp Cys Leu Gln Lys Gly Glu Ser Val Lys Phe Gln 
    610                 615                 620                 


Leu Cys Val Leu Gly Gln Asn Ala Gln Thr Met Ala Tyr Asn Ile Thr 
625                 630                 635                 640 


Pro Leu Arg Arg Ala Thr Val Glu Cys Val Lys Asp Gln Phe Gly Phe 
                645                 650                 655     


Ile Asn Tyr Glu Val Gly Asp Ser Lys Lys Leu Phe Phe His Val Lys 
            660                 665                 670         


Glu Val Gln Asp Gly Ile Glu Leu Gln Ala Gly Asp Glu Val Glu Phe 
        675                 680                 685             


Ser Val Ile Leu Asn Gln Arg Thr Gly Lys Cys Ser Ala Cys Asn Val 
    690                 695                 700                 


Trp Arg Val Cys Glu Gly Pro Lys Ala Val Ala Ala Pro Arg Pro Asp 
705                 710                 715                 720 


Arg Leu Val Asn Arg Leu Lys Asn Ile Thr Leu Asp Asp Ala Ser Ala 
                725                 730                 735     


Pro Arg Leu Met Val Leu Arg Gln Pro Arg Gly Pro Asp Asn Ser Met 
            740                 745                 750         


Gly Phe Gly Ala Glu Arg Lys Ile Arg Gln Ala Gly Val Ile Asp 
        755                 760                 765         


<210>  3
<211>  2396
<212>  DNA
<213>  Mus musculus

<400>  3
atgagctttg atccaaacct tctccacaac aatggacaca atgggtaccc caatggtact       60

tcagcagcac ttcgtgaaac tggggttatt gaaaaactct tgacctctta cggattcatt      120

cagtgttcag aacggcaagc tagacttttc ttccactgtt cacaatataa tggcaacctc      180

caagacttaa aagtaggaga tgatgttgaa tttgaagtat catctgaccg gaggactggg      240

aaacctattg ctattaaatt ggtgaagata aaaccagaaa tacatcctga agaacgaatg      300

aacggacaag ttgtgtgcgc tgttcctcac aacttagaga gtaaatctcc agctgccccg      360

ggtcagagtc caacagggag tgtatgctac gaacgtaatg gggaagtatt ttatctgact      420

tacacctctg aagatgtgga agggaatgtt cagctggaaa ctggagataa aattaacttt      480

gtaattgata acaataaaca cactggtgct gtaagtgctc gtaatattat gctgttgaaa      540

aagaagcagg ctcgctgtca aggagtagtt tgtgccatga aggaggcgtt tggctttatc      600

gaaagaggtg atgttgtaaa agagatattc tttcactata gtgaatttaa aggtgaccta      660

gaaaccctac agcctggaga tgacgtggaa ttcacaatca aggacagaaa tggtaaagaa      720

gttgcaacag atgtcagact attgcctcaa ggaacagtca tttttgaaga tatcagcatt      780

gaacattttg aaggaactgt aaccaaagtt atcccaaaag tacccagtaa aaaccagaat      840

gacccattgc caggacgaat caaagttgac tttgtgattc ctaaagaact tccctttgga      900

gacaaagaca caaaatccaa agtgaccctg ctggaaggtg accatgttag gtttaatatt      960

tcaacagacc gacgtgacaa attggaacga gcaaccaaca tagaggttct atcaaataca     1020

tttcagttca ctaatgaagc cagagagatg ggtgtgattg ctgccatgag agatggtttt     1080

ggtttcatca agtgtgtgga tcgtgatgct cgtatgttct tccacttcag tgagattcta     1140

gatgggaacc agctccacat tgcagatgaa gtagagttta ctgtggttcc tgatatgctc     1200

tctgcccaaa gaaatcatgc tattaggatt aaaaaacttc ccaagggcac ggtttcattc     1260

cattcccatt cagatcatcg ttttctgggc accgtagaaa aagaagccac tttttccaat     1320

cctaaaacta caagcccaaa taaaggcaaa gacaaggagg cagaagatgg cattatagct     1380

tatgacgact gtggggtgaa actgacgatt gcttttcaag ccaaggatgt ggaaggatct     1440

acttctcctc aaataggaga taaggttgaa tttagtatta gtgacaaaca gaggcctgga     1500

cagcagattg caacttgcgg agacttttag gtcgtaattc taactccaaa cgtctcttgg     1560

gttatgtggc aactctgaaa gataattttg gatttataga aacagctaat catgataagg     1620

aaatattttt ccactatagt gagttctctg gtgatgttga tagcctggaa ctgggagaca     1680

tggttgaata cagcttgtcc aaaggcaaag gcaataaagt cagtgctgag aaagtaaaca     1740

aagcccactc agtgaatggc attactgagg aagctaatcc caccatctac tctggtaaag     1800

tcattcgccc tctgagaggt gttgatccaa cacagattga gtaccaagga atgattgaga     1860

ttgtggagga gggggatatg aaaggtgaag tgtatccttt tggcatagtt gggatggcca     1920

acaaagggga ttgcctacag aaaggggaga gtgtcaagtt ccagttgtgt gtacttggcc     1980

aaaatgcaca aactatggcc tacaacatca caccccttcg tagggctact gtggagtgtg     2040

tgaaagatca gtttggcttt attaactatg aagtaggaga tagcaagaag ctctttttcc     2100

atgtgaaaga agttcaggat ggcgttgagc tacaggcagg agatgaggtg gaattctcag     2160

tgatccttaa tcagcgcact gggaagtgca gtgcctgtaa tgtctggcga gtctgtgaag     2220

gccccaaagc tgttgcagct cctcgacctg accggttggt caatcgccta aagaacatca     2280

ccctggatga tgccagtgct ccacgtctaa tggttcttcg tcagccaagg ggaccagata     2340

actcaatggg atttggtgca gaaagaaaga tccgtcaagc tggtgtcatt gactaa         2396


<210>  4
<211>  13
<212>  PRT
<213>  Human immunodeficiency virus

<400>  4

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  5
<211>  16
<212>  PRT
<213>  Drosophila melanogaster

<400>  5

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  6
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  6

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  7
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  7
atgagctttg atccaaacct tc                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  8
atgagctttg attcaaacct tc                                                22


<210>  9
<211>  40
<212>  DNA
<213>  Vesicular stomatitis virus

<400>  9
cactatagac aatgaaaaaa agtatcagat gtctcttata                             40


<210>  10
<211>  15
<212>  DNA
<213>  Vesicular stomatitis virus

<400>  10
gttacttttt ttcat                                                        15


<210>  11
<211>  40
<212>  DNA
<213>  Vesicular stomatitis virus

<400>  11
cactatagac aataaaaaaa agtatcagat gtctcttata                             40


<210>  12
<211>  15
<212>  DNA
<213>  Vesicular stomatitis virus mutant

<400>  12
gttatttttt ttcat                                                        15


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Val Pro Arg Asn Gln Asp Trp Leu 
1               5                   


<210>  14
<211>  8
<212>  PRT
<213>  Gallus gallus

<400>  14

Ser Ile Ile Asn Phe Glu Lys Leu 
1               5               


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  15
tcacgaagtg ctgctgaagt                                                   20


<210>  16
<211>  13641
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide construct

<400>  16
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcgtagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggcttgtat     1620

gcaccagatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aacagcctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacgctca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggactc tatcggccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctcccc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagatcga     3060

tctgtttacg cgtcactatg aagtgccttt tgtacttagc ctttttattc attggggtga     3120

attgcaagtt caccatagtt tttccacaca accaaaaagg aaactggaaa aatgttcctt     3180

ctaattacca ttattgcccg tcaagctcag atttaaattg gcataatgac ttaataggca     3240

cagccttaca agtcaaaatg cccaagagtc acaaggctat tcaagcagac ggttggatgt     3300

gtcatgcttc caaatgggtc actacttgtg atttccgctg gtatggaccg aagtatataa     3360

cacattccat ccgatccttc actccatctg tagaacaatg caaggaaagc attgaacaaa     3420

cgaaacaagg aacttggctg aatccaggct tccctcctca aagttgtgga tatgcaactg     3480

tgacggatgc cgaagcagtg attgtccagg tgactcctca ccatgtgctg gttgatgaat     3540

acacaggaga atgggttgat tcacagttca tcaacggaaa atgcagcaat tacatatgcc     3600

ccactgtcca taactctaca acctggcatt ctgactataa ggtcaaaggg ctatgtgatt     3660

ctaacctcat ttccatggac atcaccttct tctcagagga cggagagcta tcatccctgg     3720

gaaaggaggg cacagggttc agaagtaact actttgctta tgaaactgga ggcaaggcct     3780

gcaaaatgca atactgcaag cattggggag tcagactccc atcaggtgtc tggttcgaga     3840

tggctgataa ggatctcttt gctgcagcca gattccctga atgcccagaa gggtcaagta     3900

tctctgctcc atctcagacc tcagtggatg taagtctaat tcaggacgtt gagaggatct     3960

tggattattc cctctgccaa gaaacctgga gcaaaatcag agcgggtctt ccaatctctc     4020

cagtggatct cagctatctt gctcctaaaa acccaggaac cggtcctgct ttcaccataa     4080

tcaatggtac cctaaaatac tttgagacca gatacatcag agtcgatatt gctgctccaa     4140

tcctctcaag aatggtcgga atgatcagtg gaactaccac agaaagggaa ctgtgggatg     4200

actgggcacc atatgaagac gtggaaattg gacccaatgg agttctgagg accagttcag     4260

gatataagtt tcctttatac atgattggac atggtatgtt ggactccgat cttcatctta     4320

gctcaaaggc tcaggtgttc gaacatcctc acattcaaga cgctgcttcg caacttcctg     4380

atgatgagag tttatttttt ggtgatactg ggctatccaa aaatccaatc gagcttgtag     4440

aaggttggtt cagtagttgg aaaagctcta ttgcctcttt tttctttatc atagggttaa     4500

tcattggact attcttggtt ctccgagttg gtatccatct ttgcattaaa ttaaagcaca     4560

ccaagaaaag acagatttat acagacatag agatgaaccg acttggaaag taactcaaat     4620

cctgctaggt atgaaaaaaa ctaacagata tcacgctcga gaattaattg ctaggtatga     4680

aaaaaactaa cagatatcac gctcgagatg agctttgatc caaaccttct ccacaacaat     4740

ggacacaatg ggtaccccaa tggtacttca gcagcacttc gtgaaactgg ggttattgaa     4800

aaactcttga cctcttacgg attcattcag tgttcagaac ggcaagctag acttttcttc     4860

cactgttcac aatataatgg caacctccaa gacttaaaag taggagatga tgttgaattt     4920

gaagtatcat ctgaccggag gactgggaaa cctattgcta ttaaattggt gaagataaaa     4980

ccagaaatac atcctgaaga acgaatgaac ggacaagttg tgtgcgctgt tcctcacaac     5040

ttagagagta aatctccagc tgccccgggt cagagtccaa cagggagtgt atgctacgaa     5100

cgtaatgggg aagtatttta tctgacttac acctctgaag atgtggaagg gaatgttcag     5160

ctggaaactg gagataaaat taactttgta attgataaca ataaacacac tggtgctgta     5220

agtgctcgta atattatgct gttgaaaaag aagcaggctc gctgtcaagg agtagtttgt     5280

gccatgaagg aggcgtttgg ctttatcgaa agaggtgatg ttgtaaaaga gatattcttt     5340

cactatagtg aatttaaagg tgacctagaa accctacagc ctggagatga cgtggaattc     5400

acaatcaagg acagaaatgg taaagaagtt gcaacagatg tcagactatt gcctcaagga     5460

acagtcattt ttgaagatat cagcattgaa cattttgaag gaactgtaac caaagttatc     5520

ccaaaagtac ccagtaaaaa ccagaatgac ccattgccag gacgaatcaa agttgacttt     5580

gtgattccta aagaacttcc ctttggagac aaagacacaa aatccaaagt gaccctgctg     5640

gaaggtgacc atgttaggtt taatatttca acagaccgac gtgacaaatt ggaacgagca     5700

accaacatag aggttctatc aaatacattt cagttcacta atgaagccag agagatgggt     5760

gtgattgctg ccatgagaga tggttttggt ttcatcaagt gtgtggatcg tgatgctcgt     5820

atgttcttcc acttcagtga gattctagat gggaaccagc tccacattgc agatgaagta     5880

gagtttactg tggttcctga tatgctctct gcccaaagaa atcatgctat taggattaaa     5940

aaacttccca agggcacggt ttcattccat tcccattcag atcatcgttt tctgggcacc     6000

gtagaaaaag aagccacttt ttccaatcct aaaactacaa gcccaaataa aggcaaagac     6060

aaggaggcag aagatggcat tatagcttat gacgactgtg gggtgaaact gacgattgct     6120

tttcaagcca aggatgtgga aggatctact tctcctcaaa taggagataa ggttgaattt     6180

agtattagtg acaaacagag gcctggacag cagattgcaa cttgcggaga cttttaggtc     6240

gtaattctaa ctccaaacgt ctcttgggtt atgtggcaac tctgaaagat aattttggat     6300

ttatagaaac agctaatcat gataaggaaa tatttttcca ctatagtgag ttctctggtg     6360

atgttgatag cctggaactg ggagacatgg ttgaatacag cttgtccaaa ggcaaaggca     6420

ataaagtcag tgctgagaaa gtaaacaaag cccactcagt gaatggcatt actgaggaag     6480

ctaatcccac catctactct ggtaaagtca ttcgccctct gagaggtgtt gatccaacac     6540

agattgagta ccaaggaatg attgagattg tggaggaggg ggatatgaaa ggtgaagtgt     6600

atccttttgg catagttggg atggccaaca aaggggattg cctacagaaa ggggagagtg     6660

tcaagttcca gttgtgtgta cttggccaaa atgcacaaac tatggcctac aacatcacac     6720

cccttcgtag ggctactgtg gagtgtgtga aagatcagtt tggctttatt aactatgaag     6780

taggagatag caagaagctc tttttccatg tgaaagaagt tcaggatggc gttgagctac     6840

aggcaggaga tgaggtggaa ttctcagtga tccttaatca gcgcactggg aagtgcagtg     6900

cctgtaatgt ctggcgagtc tgtgaaggcc ccaaagctgt tgcagctcct cgacctgacc     6960

ggttggtcaa tcgcctaaag aacatcaccc tggatgatgc cagtgctcca cgtctaatgg     7020

ttcttcgtca gccaagggga ccagataact caatgggatt tggtgcagaa agaaagatcc     7080

gtcaagctgg tgtcattgac taagctagcc agattcttca tgtttggacc aaatcaactt     7140

gtgataccat gctcaaagag gcctcaatta tatttgagtt tttaattttt atgaaaaaaa     7200

ctaacagcaa tcatggaagt ccacgatttt gagaccgacg agttcaatga tttcaatgaa     7260

gatgactatg ccacaagaga attcctgaat cccgatgagc gcatgacgta cttgaatcat     7320

gctgattaca acctgaattc tcctctaatt agtgatgata ttgacaattt aatcaggaaa     7380

ttcaattctc ttccaattcc ctcgatgtgg gatagtaaga actgggatgg agttcttgag     7440

atgttaacgt catgtcaagc caatcccatc ccaacatctc agatgcataa atggatggga     7500

agttggttaa tgtctgataa tcatgatgcc agtcaagggt atagtttttt acatgaagtg     7560

gacaaagagg cagaaataac atttgacgtg gtggagacct tcatccgcgg ctggggcaac     7620

aaaccaattg aatacatcaa aaaggaaaga tggactgact cattcaaaat tctcgcttat     7680

ttgtgtcaaa agtttttgga cttacacaag ttgacattaa tcttaaatgc tgtctctgag     7740

gtggaattgc tcaacttggc gaggactttc aaaggcaaag tcagaagaag ttctcatgga     7800

acgaacatat gcaggattag ggttcccagc ttgggtccta cttttatttc agaaggatgg     7860

gcttacttca agaaacttga tattctaatg gaccgaaact ttctgttaat ggtcaaagat     7920

gtgattatag ggaggatgca aacggtgcta tccatggtat gtagaataga caacctgttc     7980

tcagagcaag acatcttctc ccttctaaat atctacagaa ttggagataa aattgtggag     8040

aggcagggaa atttttctta tgacttgatt aaaatggtgg aaccgatatg caacttgaag     8100

ctgatgaaat tagcaagaga atcaaggcct ttagtcccac aattccctca ttttgaaaat     8160

catatcaaga cttctgttga tgaaggggca aaaattgacc gaggtataag attcctccat     8220

gatcagataa tgagtgtgaa aacagtggat ctcacactgg tgatttatgg atcgttcaga     8280

cattggggtc atccttttat agattattac actggactag aaaaattaca ttcccaagta     8340

accatgaaga aagatattga tgtgtcatat gcaaaagcac ttgcaagtga tttagctcgg     8400

attgttctat ttcaacagtt caatgatcat aaaaagtggt tcgtgaatgg agacttgctc     8460

cctcatgatc atccctttaa aagtcatgtt aaagaaaata catggcccac agctgctcaa     8520

gttcaagatt ttggagataa atggcatgaa cttccgctga ttaaatgttt tgaaataccc     8580

gacttactag acccatcgat aatatactct gacaaaagtc attcaatgaa taggtcagag     8640

gtgttgaaac atgtccgaat gaatccgaac actcctatcc ctagtaaaaa ggtgttgcag     8700

actatgttgg acacaaaggc taccaattgg aaagaatttc ttaaagagat tgatgagaag     8760

ggcttagatg atgatgatct aattattggt cttaaaggaa aggagaggga actgaagttg     8820

gcaggtagat ttttctccct aatgtcttgg aaattgcgag aatactttgt aattaccgaa     8880

tatttgataa agactcattt cgtccctatg tttaaaggcc tgacaatggc ggacgatcta     8940

actgcagtca ttaaaaagat gttagattcc tcatccggcc aaggattgaa gtcatatgag     9000

gcaatttgca tagccaatca cattgattac gaaaaatgga ataaccacca aaggaagtta     9060

tcaaacggcc cagtgttccg agttatgggc cagttcttag gttatccatc cttaatcgag     9120

agaactcatg aattttttga gaaaagtctt atatactaca atggaagacc agacttgatg     9180

cgtgttcaca acaacacact gatcaattca acctcccaac gagtttgttg gcaaggacaa     9240

gagggtggac tggaaggtct acggcaaaaa ggatggagta tcctcaatct actggttatt     9300

caaagagagg ctaaaatcag aaacactgct gtcaaagtct tggcacaagg tgataatcaa     9360

gttatttgca cacagtataa aacgaagaaa tcgagaaacg ttgtagaatt acagggtgct     9420

ctcaatcaaa tggtttctaa taatgagaaa attatgactg caatcaaaat agggacaggg     9480

aagttaggac ttttgataaa tgacgatgag actatgcaat ctgcagatta cttgaattat     9540

ggaaaaatac cgattttccg tggagtgatt agagggttag agaccaagag atggtcacga     9600

gtgacttgtg tcaccaatga ccaaataccc acttgtgcta atataatgag ctcagtttcc     9660

acaaatgctc tcaccgtagc tcattttgct gagaacccaa tcaatgccat gatacagtac     9720

aattattttg ggacatttgc tagactcttg ttgatgatgc atgatcctgc tcttcgtcaa     9780

tcattgtatg aagttcaaga taagataccg ggcttgcaca gttctacttt caaatacgcc     9840

atgttgtatt tggacccttc cattggagga gtgtcgggca tgtctttgtc caggtttttg     9900

attagagcct tcccagatcc cgtaacagaa agtctctcat tctggagatt catccatgta     9960

catgctcgaa gtgagcatct gaaggagatg agtgcagtat ttggaaaccc cgagatagcc    10020

aagtttcgaa taactcacat agacaagcta gtagaagatc caacctctct gaacatcgct    10080

atgggaatga gtccagcgaa cttgttaaag actgaggtta aaaaatgctt aatcgaatca    10140

agacaaacca tcaggaacca ggtgattaag gatgcaacca tatatttgta tcatgaagag    10200

gatcggctca gaagtttctt atggtcaata aatcctctgt tccctagatt tttaagtgaa    10260

ttcaaatcag gcactttttt gggagtcgca gacgggctca tcagtctatt tcaaaattct    10320

cgtactattc ggaactcctt taagaaaaag tatcataggg aattggatga tttgattgtg    10380

aggagtgagg tatcctcttt gacacattta gggaaacttc atttgagaag gggatcatgt    10440

aaaatgtgga catgttcagc tactcatgct gacacattaa gatacaaatc ctggggccgt    10500

acagttattg ggacaactgt accccatcca ttagaaatgt tgggtccaca acatcgaaaa    10560

gagactcctt gtgcaccatg taacacatca gggttcaatt atgtttctgt gcattgtcca    10620

gacgggatcc atgacgtctt tagttcacgg ggaccattgc ctgcttatct agggtctaaa    10680

acatctgaat ctacatctat tttgcagcct tgggaaaggg aaagcaaagt cccactgatt    10740

aaaagagcta cacgtcttag agatgctatc tcttggtttg ttgaacccga ctctaaacta    10800

gcaatgacta tactttctaa catccactct ttaacaggcg aagaatggac caaaaggcag    10860

catgggttca aaagaacagg gtctgccctt cataggtttt cgacatctcg gatgagccat    10920

ggtgggttcg catctcagag cactgcagca ttgaccaggt tgatggcaac tacagacacc    10980

atgagggatc tgggagatca gaatttcgac tttttattcc aagcaacgtt gctctatgct    11040

caaattacca ccactgttgc aagagacgga tggatcacca gttgtacaga tcattatcat    11100

attgcctgta agtcctgttt gagacccata gaagagatca ccctggactc aagtatggac    11160

tacacgcccc cagatgtatc ccatgtgctg aagacatgga ggaatgggga aggttcgtgg    11220

ggacaagaga taaaacagat ctatccttta gaagggaatt ggaagaattt agcacctgct    11280

gagcaatcct atcaagtcgg cagatgtata ggttttctat atggagactt ggcgtataga    11340

aaatctactc atgccgagga cagttctcta tttcctctat ctatacaagg tcgtattaga    11400

ggtcgaggtt tcttaaaagg gttgctagac ggattaatga gagcaagttg ctgccaagta    11460

atacaccgga gaagtctggc tcatttgaag aggccggcca acgcagtgta cggaggtttg    11520

atttacttga ttgataaatt gagtgtatca cctccattcc tttctcttac tagatcagga    11580

cctattagag acgaattaga aacgattccc cacaagatcc caacctccta tccgacaagc    11640

aaccgtgata tgggggtgat tgtcagaaat tacttcaaat accaatgccg tctaattgaa    11700

aagggaaaat acagatcaca ttattcacaa ttatggttat tctcagatgt cttatccata    11760

gacttcattg gaccattctc tatttccacc accctcttgc aaatcctata caagccattt    11820

ttatctggga aagataagaa tgagttgaga gagctggcaa atctttcttc attgctaaga    11880

tcaggagagg ggtgggaaga catacatgtg aaattcttca ccaaggacat attattgtgt    11940

ccagaggaaa tcagacatgc ttgcaagttc gggattgcta aggataataa taaagacatg    12000

agctatcccc cttggggaag ggaatccaga gggacaatta caacaatccc tgtttattat    12060

acgaccaccc cttacccaaa gatgctagag atgcctccaa gaatccaaaa tcccctgctg    12120

tccggaatca ggttgggcca attaccaact ggcgctcatt ataaaattcg gagtatatta    12180

catggaatgg gaatccatta cagggacttc ttgagttgtg gagacggctc cggagggatg    12240

actgctgcat tactacgaga aaatgtgcat agcagaggaa tattcaatag tctgttagaa    12300

ttatcagggt cagtcatgcg aggcgcctct cctgagcccc ccagtgccct agaaacttta    12360

ggaggagata aatcgagatg tgtaaatggt gaaacatgtt gggaatatcc atctgactta    12420

tgtgacccaa ggacttggga ctatttcctc cgactcaaag caggcttggg gcttcaaatt    12480

gatttaattg taatggatat ggaagttcgg gattcttcta ctagcctgaa aattgagacg    12540

aatgttagaa attatgtgca ccggattttg gatgagcaag gagttttaat ctacaagact    12600

tatggaacat atatttgtga gagcgaaaag aatgcagtaa caatccttgg tcccatgttc    12660

aagacggtcg acttagttca aacagaattt agtagttctc aaacgtctga agtatatatg    12720

gtatgtaaag gtttgaagaa attaatcgat gaacccaatc ccgattggtc ttccatcaat    12780

gaatcctgga aaaacctgta cgcattccag tcatcagaac aggaatttgc cagagcaaag    12840

aaggttagta catactttac cttgacaggt attccctccc aattcattcc tgatcctttt    12900

gtaaacattg agactatgct acaaatattc ggagtaccca cgggtgtgtc tcatgcggct    12960

gccttaaaat catctgatag acctgcagat ttattgacca ttagcctttt ttatatggcg    13020

attatatcgt attataacat caatcatatc agagtaggac cgatacctcc gaacccccca    13080

tcagatggaa ttgcacaaaa tgtggggatc gctataactg gtataagctt ttggctgagt    13140

ttgatggaga aagacattcc actatatcaa cagtgtttag cagttatcca gcaatcattc    13200

ccgattaggt gggaggctgt ttcagtaaaa ggaggataca agcagaagtg gagtactaga    13260

ggtgatgggc tcccaaaaga tacccgaatt tcagactcct tggccccaat cgggaactgg    13320

atcagatctc tggaattggt ccgaaaccaa gttcgtctaa atccattcaa tgagatcttg    13380

ttcaatcagc tatgtcgtac agtggataat catttgaaat ggtcaaattt gcgaagaaac    13440

acaggaatga ttgaatggat caatagacga atttcaaaag aagaccggtc tatactgatg    13500

ttgaagagtg acctacacga ggaaaactct tggagagatt aaaaaatcat gaggagactc    13560

caaactttaa gtatgaaaaa aactttgatc cttaagaccc tcttgtggtt tttatttttt    13620

atctggtttt gtggtcttcg t                                              13641


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Phe Asp Pro Asn Leu Leu His
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens mutant

<400>  18

Met Ser Phe Asp Ser Asn Leu Leu His
1               5                   