                         SEQUENCE LISTING

<110>  Sunshine Lake Pharma Co., Ltd.
 
<120>  VIRAL VECTORS AND USES THEREOF

<130>  SI4210293

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  495
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1

<400>  1

Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
1               5                   10                  15      


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
            20                  25                  30          


His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met Pro Gln Ser 
        35                  40                  45              


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
    50                  55                  60                  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr Gln 
65                  70                  75                  80  


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
                85                  90                  95      


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
            100                 105                 110         


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
        115                 120                 125             


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
    130                 135                 140                 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
145                 150                 155                 160 


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
                165                 170                 175     


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
            180                 185                 190         


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
        195                 200                 205             


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
    210                 215                 220                 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
225                 230                 235                 240 


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
                245                 250                 255     


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
            260                 265                 270         


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
        275                 280                 285             


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
    290                 295                 300                 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
305                 310                 315                 320 


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
                325                 330                 335     


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
            340                 345                 350         


Glu Gln Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
        355                 360                 365             


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
    370                 375                 380                 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
385                 390                 395                 400 


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
                405                 410                 415     


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
            420                 425                 430         


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
        435                 440                 445             


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
    450                 455                 460                 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
465                 470                 475                 480 


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                485                 490                 495 


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  2

<400>  2

Ala Ala Ala Thr Thr Thr 
1               5       


<210>  3
<211>  91
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3

<400>  3

Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp 
1               5                   10                  15      


Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu 
            20                  25                  30          


Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe 
        35                  40                  45              


Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val 
    50                  55                  60                  


Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile 
65                  70                  75                  80  


Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                85                  90      


<210>  4
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4

<400>  4

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser Ala Ala Ala Thr Thr Thr Phe Glu His Pro His Ile Gln Asp 
                245                 250                 255     


Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr 
            260                 265                 270         


Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser 
        275                 280                 285             


Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile 
    290                 295                 300                 


Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu 
305                 310                 315                 320 


Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg 
                325                 330                 335     


Leu Gly Lys 
            


<210>  5
<211>  1533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5

<400>  5
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcaa gttcaccata       60

gtttttccac acaaccaaaa aggaaactgg aaaaatgttc cttctaatta ccattattgc      120

ccgtcaagct cagatttaaa ttggcataat gacttaatag gcacagcctt acaagtcaaa      180

atgccccaaa gtcacaaggc tattcaagca gacggttgga tgtgtcatgc ttccaaatgg      240

gtcactactt gtgatttccg ctggtatgga ccgaagtata taacacattc catccgatcc      300

ttcactccat ctgtagaaca atgcaaggaa agcattgaac aaacgaaaca aggaacttgg      360

ctgaatccag gcttccctcc tcaaagttgt ggatatgcaa ctgtgacgga tgccgaagca      420

gtgattgtcc aggtgactcc tcaccatgtg ctggttgatg aatacacagg agaatgggtt      480

gattcacagt tcatcaacgg aaaatgcagc aattacatat gccccactgt ccataactct      540

acaacctggc attctgacta taaggtcaaa gggctatgtg attctaacct catttccatg      600

gacatcacct tcttctcaga ggacggagag ctatcatccc tgggaaagga gggcacaggg      660

ttcagaagta actactttgc ttatgaaact ggaggcaagg cctgcaaaat gcaatactgc      720

aagcattggg gagtcagact cccatcaggt gtctggttcg agatggctga taaggatctc      780

tttgctgcag ccagattccc tgaatgccca gaagggtcaa gtatctctgc tccatctcag      840

acctcagtgg atgtaagtct aattcaggac gttgagagga tcttggatta ttccctctgc      900

caagaaacct ggagcaaaat cagagcgggt cttccaatct ctccagtgga tctcagctat      960

cttgctccta aaaacccagg aaccggtcct gctttcacca taatcaatgg taccctaaaa     1020

tactttgaga ccagatacat cagagtcgat attgctgctc caatcctctc aagaatggtc     1080

ggaatgatca gtggaactac cacagaacag gaactgtggg atgactgggc accatatgaa     1140

gacgtggaaa ttggacccaa tggagttctg aggaccagtt caggatataa gtttccttta     1200

tacatgattg gacatggtat gttggactcc gatcttcatc ttagctcaaa ggctcaggtg     1260

ttcgaacatc ctcacattca agacgctgct tcgcaacttc ctgatgatga gagtttattt     1320

tttggtgata ctgggctatc caaaaatcca atcgagcttg tagaaggttg gttcagtagt     1380

tggaaaagct ctattgcctc ttttttcttt atcatagggt taatcattgg actattcttg     1440

gttctccgag ttggtatcca tctttgcatt aaattaaagc acaccaagaa aagacagatt     1500

tatacagaca tagagatgaa ccgacttgga aag                                  1533


<210>  6
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6

<400>  6
atgaagtgcc ttttgtactt agccttttta ttcattgggg tgaattgcga cattcagatg       60

actcagacca cctcctccct gtccgcctcc ctgggcgacc gcgtgaccat ctcatgccgc      120

gccagccagg acatctcgaa gtacctcaac tggtaccagc agaagcccga cggaaccgtg      180

aagctcctga tctaccacac ctcccggctg cacagcggag tgccgtctag attctcgggt      240

tcggggtcgg gaactgacta ctcccttact atttccaacc tggagcagga ggatattgcc      300

acctacttct gccaacaagg aaacaccctg ccgtacactt ttggcggggg aaccaagctg      360

gaaatcactg ggggcggagg atccggtgga ggcggaagcg ggggtggagg atccgaagtc      420

aagctgcagg aatcaggacc tggcctggtg gccccgagcc agtcactgtc cgtgacttgt      480

actgtgtccg gagtgtcgct cccggattac ggagtgtcct ggatcaggca gccacctcgg      540

aaaggattgg aatggctcgg agtcatctgg ggttccgaaa ccacctatta caactcggca      600

ctgaaatcca ggctcaccat tatcaaggat aactccaagt cacaagtgtt cctgaagatg      660

aatagcctgc agactgacga cacggcgatc tactattgcg ccaagcacta ctactacggc      720

ggatcctacg ctatggacta ctggggccag gggaccagcg tgaccgtgtc atccgcggcc      780

gcaactacca ccttcgaaca tcctcacatt caagacgctg cttcgcaact tcctgatgat      840

gagagtttat tttttggtga tactgggcta tccaaaaatc caatcgagct tgtagaaggt      900

tggttcagta gttggaaaag ctctattgcc tcttttttct ttatcatagg gttaatcatt      960

ggactattct tggttctccg agttggtatc catctttgca ttaaattaaa gcacaccaag     1020

aaaagacaga tttatacaga catagagatg aaccgacttg gaaag                     1065


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  7

<400>  7

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


<210>  8
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8

<400>  8

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  9
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9

<400>  9

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Thr Trp Val Ile 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr Cys Gly 
                165                 170                 175     


Ser Asp Thr Met His Tyr Asn Glu Lys Phe Lys Asn Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Trp Trp Asp Tyr 
    210                 215                 220                 


Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  10
<211>  341
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10

<400>  10

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Met Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Thr Trp Val Ile 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Asp Ile Tyr Cys Gly 
                165                 170                 175     


Ser Asp Thr Met His Tyr Asn Glu Lys Phe Lys Asn Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Trp Trp Asp Tyr 
    210                 215                 220                 


Gly Ser Ser Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Phe Glu His Pro His Ile 
                245                 250                 255     


Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly 
            260                 265                 270         


Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe 
        275                 280                 285             


Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu 
    290                 295                 300                 


Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile 
305                 310                 315                 320 


Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
                325                 330                 335     


Asn Arg Leu Gly Lys 
            340     


