                         SEQUENCE LISTING

<110>  ACADEMIA SINICA
 
<120>  POTENT NEUTRALIZING ANTIBODIES FOR PREVENTION AND TREATMENT OF 
       COVID-19

<130>  10011-100PCT

<150>  63167109
<151>  2021-03-28

<150>  63086206
<151>  2020-10-01

<160>  94    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer E-Sarbeco-F1

<400>  1
acaggtacgt taatagttaa tagcgt                                            26


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer E-Sarbeco-R2

<400>  2
atattgcagc agtacgcaca ca                                                22


<210>  3
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe E-Sarbeco-P1

<400>  3
acactagcca tccttactgc gcttcg                                            26


<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH FR1

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH CDR1

<400>  5

Gly Tyr Ser Phe Thr Thr Tyr Trp 
1               5               


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH FR2

<400>  6

Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile Gly 
1               5                   10                  15      


Met 
    


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH CDR2

<400>  7

Ile Asp Pro Ser Asp Ser Glu Thr 
1               5               


<210>  8
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH FR3

<400>  8

Arg Leu Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Pro Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  9
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH CDR3

<400>  9

Ala Arg Asp Phe Asp Tyr Asp Arg Thr Met Asp Tyr 
1               5                   10          


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH FR4

<400>  10

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  11
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH FR1

<400>  11

Glu Val Gln Leu Glu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser 
            20                  25  


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH CDR1

<400>  12

Asp Phe Ser Leu Thr Thr Tyr Gly 
1               5               


<210>  13
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH FR2

<400>  13

Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  15      


Val 
    


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH CDR2

<400>  14

Ile Trp Ser Gly Gly Ser Thr 
1               5           


<210>  15
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH FR3

<400>  15

Asp Tyr Asn Ala Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn 
1               5                   10                  15      


Ser Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln Thr Asn Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH CDR3

<400>  16

Ala Arg Met Gly Asp Gly Tyr Tyr Val Gly Ala Met Asp Tyr 
1               5                   10                  


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH FR4

<400>  17

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  18
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH FR1

<400>  18

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH CDR1

<400>  19

Gly Phe Thr Phe Ser Ser Tyr Thr 
1               5               


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH FR2

<400>  20

Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Glu 
    


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH CDR2

<400>  21

Ile Ser Ser Gly Gly Thr Tyr Thr 
1               5               


<210>  22
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH FR3

<400>  22

Asn Tyr Pro Asp Thr Ala Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys 
        35              


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH CDR3

<400>  23

Ala Asn Phe Gly Asn Tyr Glu Glu Ile Ala Tyr 
1               5                   10      


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH FR4

<400>  24

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  25
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH FR1

<400>  25

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH CDR1

<400>  26

Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH FR2

<400>  27

Leu His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Ala 
    


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH CDR2

<400>  28

Ile Asp Ser Ser Asp Ser Tyr Thr 
1               5               


<210>  29
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH FR3

<400>  29

Asp Tyr Asn Gln Asn Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Glu 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH CDR3

<400>  30

Ala Arg Gly Lys Asp Ala Tyr Asp Arg Arg Pro Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH FR4

<400>  31

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  32
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH FR1

<400>  32

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser 
            20                  25  


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH CDR1

<400>  33

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH FR2

<400>  34

Ile Tyr Trp Val Lys Gln Ser Leu Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH CDR2

<400>  35

Asn Asn Pro Asn Asn Asp Asp Thr 
1               5               


<210>  36
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH FR3

<400>  36

Thr Tyr Lys Gln Phe Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  37
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH CDR3

<400>  37

Ala Arg Asp Gly Tyr Pro Tyr Tyr Tyr Ala Leu Asp Phe 
1               5                   10              


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH FR4

<400>  38

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  39
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH FR1

<400>  39

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Ala Lys Ile Ser Cys Lys Thr Ser 
            20                  25  


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH CDR1

<400>  40

Gly Tyr Thr Phe Thr Glu Tyr Thr 
1               5               


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH FR2

<400>  41

Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH CDR2

<400>  42

Ile Asn Pro Asn Asn Gly Asp Thr 
1               5               


<210>  43
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH FR3

<400>  43

Thr Tyr Asn Gln Thr Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH CDR3

<400>  44

Ala Arg Asp Gly Tyr Pro Phe Tyr Tyr Ala Leu Asp Tyr 
1               5                   10              


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH FR4

<400>  45

Trp Gly Gln Gly Ile Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  46
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VL FR1

<400>  46

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser 
            20                  25      


<210>  47
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VL CDR1

<400>  47

Gln Ser Leu Leu Phe Ser Ser Ser Gln Lys Asn Tyr 
1               5                   10          


<210>  48
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VL FR2

<400>  48

Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Phe 
    


<210>  49
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VL FR3

<400>  49

Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VL CDR3

<400>  50

Lys Gln Tyr Tyr Lys Tyr Pro Leu Thr 
1               5                   


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VL FR4

<400>  51

Phe Gly Ala Gly Thr Lys Leu Asp Ile Lys 
1               5                   10  


<210>  52
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VL FR1

<400>  52

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser 
            20                  25      


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VL CDR1

<400>  53

Gln Ser Ile Gly Thr Ser 
1               5       


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VL FR2

<400>  54

Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg His Leu Ile 
1               5                   10                  15      


Lys 
    


<210>  55
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VL FR3

<400>  55

Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asn Gly Val Glu Ser Glu Asp Ile Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VL CDR3

<400>  56

Gln Gln Gly His Asn Trp Pro Leu Thr 
1               5                   


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VL FR4

<400>  57

Phe Gly Ala Gly Thr Lys Leu Asp Ile Lys 
1               5                   10  


<210>  58
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VL FR1

<400>  58

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser 
            20                  25      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL CDR1

<400>  59

Ser Ser Val Ser Ser Ser Tyr 
1               5           


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL FR2

<400>  60

Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  61
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL FR3

<400>  61

Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL CDR3

<400>  62

His Gln Tyr His Arg Ser Pro Tyr Thr 
1               5                   


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL FR4

<400>  63

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  64
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL FR1

<400>  64

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser 
            20                  25      


<210>  65
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL CDR1

<400>  65

Gln Gly Ile Arg Tyr Tyr 
1               5       


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL FR2

<400>  66

Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  67
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL FR3

<400>  67

Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL CDR3

<400>  68

Gln Gln Tyr Asn Lys Leu Pro Tyr Thr 
1               5                   


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL FR4

<400>  69

Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
1               5                   10  


<210>  70
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VL FR1

<400>  70

Asp Ile Leu Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ser Ser 
            20                  25      


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VL CDR1

<400>  71

Gln Asn Val Gly Thr Asn 
1               5       


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VL FR2

<400>  72

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  73
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VL FR3

<400>  73

Tyr Arg Tyr Ser Gly Val Pro Asp His Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Ala Asp Leu Ala 
            20                  25                  30          


Glu Tyr Phe Cys 
        35      


<210>  74
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VL CDR3

<400>  74

Gln Gln Tyr Asn Asn Tyr Pro Trp Thr 
1               5                   


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VL FR4

<400>  75

Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
1               5                   10  


<210>  76
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VL FR1

<400>  76

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Arg 
            20                  25      


<210>  77
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VL CDR1

<400>  77

Gln Ile Val Gly Thr Asn 
1               5       


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VL FR2

<400>  78

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  79
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VL FR3

<400>  79

Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Thr Asn Val His Ser Glu Asp Leu Ala 
            20                  25                  30          


Glu Phe Phe Cys 
        35      


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VL CDR3

<400>  80

His Gln Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VL FR4

<400>  81

Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
1               5                   10  


<210>  82
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VH

<400>  82

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Ile Tyr Trp Val Lys Gln Ser Leu Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Asn Asn Pro Asn Asn Asp Asp Thr Thr Tyr Lys Gln Phe Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Tyr Tyr Tyr Ala Leu Asp Phe Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  83
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-45 VL

<400>  83

Asp Ile Leu Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ser Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp His Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Ala Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  84
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VH

<400>  84

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Val Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Leu His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Ser Ser Asp Ser Tyr Thr Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Asp Ala Tyr Asp Arg Arg Pro Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  85
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-28 VL

<400>  85

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Arg Tyr Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Lys Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  86
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VH

<400>  86

Glu Val Gln Leu Glu Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Asp Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Met Gly Asp Gly Tyr Tyr Val Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  87
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-15 VL

<400>  87

Asp Ile Gln Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg His Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Gly His Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  88
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VH

<400>  88

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Ser Gly Gly Thr Tyr Thr Asn Tyr Pro Asp Thr Ala 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Phe Gly Asn Tyr Glu Glu Ile Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  89
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-25 VL

<400>  89

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  90
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VH

<400>  90

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Ala Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Asp Thr Thr Tyr Asn Gln Thr Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Phe Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Ile Ser Val Thr Val Ser Ser 
        115                 120 


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-51 VL

<400>  91

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Arg Gln Ile Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val His Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Phe Phe Cys His Gln Tyr Asn Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Asp Ile Lys 
            100                 105         


<210>  92
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VH

<400>  92

Glu Val Gln Leu Gln Gln Ser Gly Pro Gln Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Met Ile Asp Pro Ser Asp Ser Glu Thr Arg Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Phe Asp Tyr Asp Arg Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  93
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RBD-mAb-1 VL

<400>  93

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Phe Ser 
            20                  25                  30          


Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ala Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Phe Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Ile Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Tyr Tyr Lys Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Asp Ile 
            100                 105                 110         


Lys 
    


<210>  94
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S RBD

<400>  94

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


