               SEQUENCE LISTING

<110> Academia Sinica

<120> CLEC2 FUSION PROTEIN AND USES THEREOF

<130> P4149-PCT

<150> PCT/US63085123
<151> 2020-09-29

<160> 20

<170> BiSSAP 1.3

<210> 1
<211> 179
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_Extracellular domain of CLEC2

<400> 1
Leu Gly Ile Trp Ser Val Met Gln Arg Asn Tyr Leu Gln Gly Glu Asn 
1               5                   10                  15      
Glu Asn Arg Thr Gly Thr Leu Gln Gln Leu Ala Lys Arg Phe Cys Gln 
            20                  25                  30          
Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Thr Phe Lys Gly His Lys 
        35                  40                  45              
Cys Ser Pro Cys Asp Thr Asn Trp Arg Tyr Tyr Gly Asp Ser Cys Tyr 
    50                  55                  60                  
Gly Phe Phe Arg His Asn Leu Thr Trp Glu Glu Ser Lys Gln Tyr Cys 
65                  70                  75                  80  
Thr Asp Met Asn Ala Thr Leu Leu Lys Ile Asp Asn Arg Asn Ile Val 
                85                  90                  95      
Glu Tyr Ile Lys Ala Arg Thr His Leu Ile Arg Trp Val Gly Leu Ser 
            100                 105                 110         
Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser Val Ile 
        115                 120                 125             
Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn Met Asn 
    130                 135                 140                 
Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Thr Phe Cys Glu Asn 
145                 150                 155                 160 
Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Thr Lys Val Asp 
                165                 170                 175     
Gln Leu Pro 
            

<210> 2
<211> 227
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_Fc domain

<400> 2
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              
Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  
Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         
Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             
Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     
Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 
Pro Gly Lys 
225         

<210> 3
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_signal peptide

<400> 3
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      
Leu Pro Gly Ala Arg Cys 
            20          

<210> 4
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_signal peptide

<400> 4
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      
Val His Ser 
            

<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 5
Gly Gly Gly Gly Ser 
1               5   

<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 6
Glu Pro Lys Ser Ser 
1               5   

<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 7
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser 
1               5                   10      

<210> 8
<211> 436
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_CLEC2.Fc fusion protein

<400> 8
Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      
Val His Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          
Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              
Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  
Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  
Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         
Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             
Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 
Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 
Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     
Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         
Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             
Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 
Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 
Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala 
                245                 250                 255     
Ser Leu Gly Ile Trp Ser Val Met Gln Arg Asn Tyr Leu Gln Gly Glu 
            260                 265                 270         
Asn Glu Asn Arg Thr Gly Thr Leu Gln Gln Leu Ala Lys Arg Phe Cys 
        275                 280                 285             
Gln Tyr Val Val Lys Gln Ser Glu Leu Lys Gly Thr Phe Lys Gly His 
    290                 295                 300                 
Lys Cys Ser Pro Cys Asp Thr Asn Trp Arg Tyr Tyr Gly Asp Ser Cys 
305                 310                 315                 320 
Tyr Gly Phe Phe Arg His Asn Leu Thr Trp Glu Glu Ser Lys Gln Tyr 
                325                 330                 335     
Cys Thr Asp Met Asn Ala Thr Leu Leu Lys Ile Asp Asn Arg Asn Ile 
            340                 345                 350         
Val Glu Tyr Ile Lys Ala Arg Thr His Leu Ile Arg Trp Val Gly Leu 
        355                 360                 365             
Ser Arg Gln Lys Ser Asn Glu Val Trp Lys Trp Glu Asp Gly Ser Val 
    370                 375                 380                 
Ile Ser Glu Asn Met Phe Glu Phe Leu Glu Asp Gly Lys Gly Asn Met 
385                 390                 395                 400 
Asn Cys Ala Tyr Phe His Asn Gly Lys Met His Pro Thr Phe Cys Glu 
                405                 410                 415     
Asn Lys His Tyr Leu Met Cys Glu Arg Lys Ala Gly Met Thr Lys Val 
            420                 425                 430         
Asp Gln Leu Pro 
        435     

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 9
Gly Gly Pro Gly Gly Pro 
1               5       

<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 10
Gly Gly Pro Gly Gly Pro Gly Gly Pro 
1               5                   

<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 11
Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro 
1               5                   10          

<210> 12
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 12
Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro Gly Gly Pro 
1               5                   10                  15  

<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 13
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 14
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 15
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser 
            20  

<210> 16
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_linker

<400> 16
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  

<210> 17
<211> 1308
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthesized_DNA encoding CLEC2.Fc

<400> 17
atggaatgga gctgggtctt tctcttcttc ctgtcagtaa ctacaggtgt ccactccgac      60

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     120

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     180

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     240

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt     300

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     360

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     420

cagccccgag agccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     480

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     540

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     600

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     660

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     720

tccctgtctc cgggtaaagg aggcggtgga tctggcggag gtggagctag cgggatttgg     780

tctgtcatgc agcgcaatta cctacaaggt gagaatgaaa atcgcacagg aactctgcaa     840

caattagcaa agcgcttctg tcaatatgtg gtaaaacaat cagaactaaa gggcactttc     900

aaaggtcata aatgcagccc ctgtgacaca aactggagat attatggaga tagctgctat     960

gggttcttca ggcacaactt aacatgggaa gagagtaagc agtactgcac tgacatgaat    1020

gctactctcc tgaagattga caaccggaac attgtggagt acatcaaagc caggactcat    1080

ttaattcgtt gggtcggatt atctcgccag aagtcgaatg aggtctggaa gtgggaggat    1140

ggctcggtta tctcagaaaa tatgtttgag tttttggaag atggaaaagg aaatatgaat    1200

tgtgcttatt ttcataatgg gaaaatgcac cctaccttct gtgagaacaa acattattta    1260

atgtgtgaga ggaaggctgg catgaccaag gtggaccaac taccttaa                 1308


<210> 18
<211> 1255
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_SARS-CoV-2 spike protein

<400> 18
Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      
Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          
His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              
Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  
Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  
Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      
Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         
Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             
Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 
Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 
Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     
Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         
Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             
Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 
Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 
Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     
Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         
Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             
Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 
Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 
Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     
Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         
Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             
Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 
Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 
Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     
Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         
Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             
Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 
Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 
Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     
Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         
Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             
Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 
Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 
Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     
Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser 
            580                 585                 590         
Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr 
        595                 600                 605             
Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr 
    610                 615                 620                 
Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 
His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     
Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys 
            660                 665                 670         
Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala 
        675                 680                 685             
Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile 
    690                 695                 700                 
Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys 
705                 710                 715                 720 
Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu 
                725                 730                 735     
Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile 
            740                 745                 750         
Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys 
        755                 760                 765             
Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe 
    770                 775                 780                 
Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile 
785                 790                 795                 800 
Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met 
                805                 810                 815     
Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile 
            820                 825                 830         
Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr 
        835                 840                 845             
Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala 
    850                 855                 860                 
Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe 
865                 870                 875                 880 
Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn 
                885                 890                 895     
Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala 
            900                 905                 910         
Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly 
        915                 920                 925             
Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu 
    930                 935                 940                 
Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn 
945                 950                 955                 960 
Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp 
                965                 970                 975     
Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln 
            980                 985                 990         
Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn Leu Ala Ala 
        995                 1000                1005            
Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg Val Asp Phe 
    1010                1015                1020                
Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ala Ala Pro His 
1025                1030                1035                1040
Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ser Gln Glu Arg Asn 
                1045                1050                1055    
Phe Thr Thr Ala Pro Ala Ile Cys His Glu Gly Lys Ala Tyr Phe Pro 
            1060                1065                1070        
Arg Glu Gly Val Phe Val Phe Asn Gly Thr Ser Trp Phe Ile Thr Gln 
        1075                1080                1085            
Arg Asn Phe Phe Ser Pro Gln Ile Ile Thr Thr Asp Asn Thr Phe Val 
    1090                1095                1100                
Ser Gly Asn Cys Asp Val Val Ile Gly Ile Ile Asn Asn Thr Val Tyr 
1105                1110                1115                1120
Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu Leu Asp Lys 
                1125                1130                1135    
Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser 
            1140                1145                1150        
Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu 
        1155                1160                1165            
Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu 
    1170                1175                1180                
Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp Tyr Val Trp Leu 
1185                1190                1195                1200
Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met Val Thr Ile Leu Leu 
                1205                1210                1215    
Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys Gly Ala Cys Ser Cys 
            1220                1225                1230        
Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys 
        1235                1240                1245            
Gly Val Lys Leu His Tyr Thr 
    1250                1255

<210> 19
<211> 222
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_receptor binding domain

<400> 19
Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val 
            20                  25                  30          
Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              
Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  
Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp 
65                  70                  75                  80  
Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      
Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met 
            100                 105                 110         
Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr 
        115                 120                 125             
Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg 
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys 
145                 150                 155                 160 
Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr 
                165                 170                 175     
Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val 
            180                 185                 190         
Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro 
        195                 200                 205             
Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
    210                 215                 220         

<210> 20
<211> 71
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthesized_ACE2 binding motif

<400> 20
Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys 
1               5                   10                  15      
Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile 
            20                  25                  30          
Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala 
        35                  40                  45              
Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr 
    50                  55                  60                  
Gly Ile Gly Tyr Gln Pro Tyr 
65                  70      

