                         SEQUENCE LISTING

<110>  THE TRUSTEES OF DARTMOUTH COLLEGE
 
<120>  METHOD AND AGENT FOR TREATING/PREVENTING NEURODEGENERATIVE DISEASE AND ASSOCIATED NEUROINFLAMMATION AND FOR EVALUATING PUTATIVE PROPHYLACTICS/THERAPEUTICS FOR TREATING/PREVENTING NEURODEGENERATIVE DISEASE AND NEUROINFLAMMATION

<130>  1143252.005013

<140>  PCT/US2021/052964
<141>  2021-09-30

<150>  63/086,765
<151>  2020-10-02

<160>  87    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  short-guide sgRNA

<400>  1
aactctatcg tggtcgtagg                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  short-guide sgRNA

<400>  2
cgtcacaggt gggcccgtaa                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  short-guide sgRNA

<400>  3
gactacgcgt gcggcccgca                                                   20


<210>  4
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  4
gaggaagcga cgatgcccca actgtggagc                                        30


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  5
accacgatag agttggcagg atagcgggtg                                        30


<210>  6
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  6
agttggggca tcgtcgcttc ctcaaggcaa                                        30


<210>  7
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  7
ttacgggccc acctgtgacg aggtaggggt                                        30


<210>  8
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  8
gccctacccc tacctcgtca caggtgggcc                                        30


<210>  9
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  9
tcctgccaac tctatcgtgg tcgtaggagg                                        30


<210>  10
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  10
cccgctatcc tgccaactct atcgtggtcg                                        30


<210>  11
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  11
gggcgactac gcgtgcggcc cgcacggcta                                        30


<210>  12
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  12
gcccacctgt gacgaggtag gggtagggcg                                        30


<210>  13
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  13
cccagggtct acaacatcca cagccggacc                                        30


<210>  14
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  14
ccacgataga gttggcagga tagcgggtga                                        30


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  15
ttggcaggat agcgggtgac ggtccggctg                                        30


<210>  16
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  16
cagggatacc cacccaccat cccagggtct                                        30


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA targeting BRI3

<400>  17
cctggtgttc cctttaagcg aaggtggctc                                        30


<210>  18
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  18
agcggccgcc cgcctacaac ctggaggccg                                        30


<210>  19
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  19
acagggatac ccacccacca tcccagggtc                                        30


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  20
taagcgaagg tggctccaca gttggggcat                                        30


<210>  21
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  21
ccaaagggga agaggatgat ggccaggaag                                        30


<210>  22
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  22
tgggatggtg ggtgggtatc cctgtgggcg                                        30


<210>  23
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  23
cagcaaatga acccaaaggg gaagaggatg                                        30


<210>  24
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  24
tacgggccca cctgtgacga ggtaggggta                                        30


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  25
ctacgcgtgc ggcccgcacg gctacggcgc                                        30


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  26
ggcgggcggc cgctcctgca gcagcggctt                                        30


<210>  27
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  27
gaccacaagc cgctgctgca ggagcggccg                                        30


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  28
ctgcccgtct ctgctgcagg gttggggtgc                                        30


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  29
cccacctgtg acgaggtagg ggtagggcgg                                        30


<210>  30
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  30
tgatggccag gaagatgccc aggaaggtga                                        30


<210>  31
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  31
gggcctggtg ttccctttaa gcgaaggtgg                                        30


<210>  32
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  32
ctgtggatgt tgtagaccct gggatggtgg                                        30


<210>  33
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  33
aggcaaaaca gcaaatgaac ccaaagggga                                        30


<210>  34
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  34
gccgccctac ccctacctcg tcacaggtgg                                        30


<210>  35
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  35
gcaaaacagc aaatgaaccc aaaggggaag                                        30


<210>  36
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  36
gtcgtaggag gctgtcctgt ctgcaggtga                                        30


<210>  37
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  37
ggccggccag ggcgactacg cgtgcggccc                                        30


<210>  38
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  38
ggccgctcct gcagcagcgg cttgtggtcc                                        30


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  39
ggcaaaacag caaatgaacc caaaggggaa                                        30


<210>  40
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  40
cgcctacaac ctggaggccg gccagggcga                                        30


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  41
tgcgggccgc acgcgtagtc gccctggccg                                        30


<210>  42
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  42
cctgcagcag cggcttgtgg tccatggcgg                                        30


<210>  43
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  43
tctgctgcag ggttggggtg ctggaggact                                        30


<210>  44
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  44
gccggcctcc aggttgtagg cgggcggccg                                        30


<210>  45
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  45
ccggctgtgg atgttgtaga ccctgggatg                                        30


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  46
ccatggacca caagccgctg ctgcaggagc                                        30


<210>  47
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  47
tgtgacgagg taggggtagg gcggcggcgg                                        30


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  48
tggatgttgt agaccctggg atggtgggtg                                        30


<210>  49
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  49
aggagcggcc gcccgcctac aacctggagg                                        30


<210>  50
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  50
ctggccggcc tccaggttgt aggcgggcgg                                        30


<210>  51
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  51
ggatgttgta gaccctggga tggtgggtgg                                        30


<210>  52
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  52
acgaggtagg ggtagggcgg cggcgggggc                                        30


<210>  53
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  53
aggatgatgg ccaggaagat gcccaggaag                                        30


<210>  54
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  54
ctctgcccgt ctctgctgca gggttggggt                                        30


<210>  55
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  55
gacgaggtag gggtagggcg gcggcggggg                                        30


<210>  56
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  56
gttgtagacc ctgggatggt gggtgggtat                                        30


<210>  57
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  57
ggcggggatg gcgccgtagc cgtgcgggcc                                        30


<210>  58
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  58
gggttcattt gctgttttgc cttgaggaag                                        30


<210>  59
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  59
cgaggtaggg gtagggcggc ggcgggggcg                                        30


<210>  60
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  60
cctggccggc ctccaggttg taggcgggcg                                        30


<210>  61
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  61
ctggccatca tcctcttccc ctttgggttc                                        30


<210>  62
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  62
tgaacccaaa ggggaagagg atgatggcca                                        30


<210>  63
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  63
gaggtagggg tagggcggcg gcgggggcgc                                        30


<210>  64
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  64
gccgcccgcc tacaacctgg aggccggcca                                        30


<210>  65
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  65
ggccgcacgc gtagtcgccc tggccggcct                                        30


<210>  66
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  66
tgttgtagac cctgggatgg tgggtgggta                                        30


<210>  67
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  67
ggatagcggg tgacggtccg gctgtggatg                                        30


<210>  68
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  68
aactgtggag ccaccttcgc ttaaagggaa                                        30


<210>  69
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  69
cctggccatc atcctcttcc cctttgggtt                                        30


<210>  70
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  70
ttaagcgaag gtggctccac agttggggca                                        30


<210>  71
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  71
tctgcccgtc tctgctgcag ggttggggtg                                        30


<210>  72
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  72
actgtggagc caccttcgct taaagggaac                                        30


<210>  73
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  73
tttaagcgaa ggtggctcca cagttggggc                                        30


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  74
gcggggatgg cgccgtagcc gtgcgggccg                                        30


<210>  75
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  75
cgccctggcc ggcctccagg ttgtaggcgg                                        30


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  76
tccggctgtg gatgttgtag accctgggat                                        30


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  77
gcgtagtcgc cctggccggc ctccaggttg                                        30


<210>  78
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  78
ccgcctacaa cctggaggcc ggccagggcg                                        30


<210>  79
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  79
gctggaggac tgcttcacct tcctgggcat                                        30


<210>  80
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  80
gcttcacctt cctgggcatc ttcctggcca                                        30


<210>  81
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  81
gcggcggcgg gggcgcggcg gggatggcgc                                        30


<210>  82
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  82
gtctctgctg cagggttggg gtgctggagg                                        30


<210>  83
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  83
tagggcggcg gcgggggcgc ggcggggatg                                        30


<210>  84
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  84
tgctggagga ctgcttcacc ttcctgggca                                        30


<210>  85
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  85
ggtagggcgg cggcgggggc gcggcgggga                                        30


<210>  86
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  86
aggggtaggg cggcggcggg ggcgcggcgg                                        30


<210>  87
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgRNA

<400>  87
gtagggcggc ggcgggggcg cggcggggat                                        30


