
                                SEQUENCE LISTING

<110> I-MAB BIOPHARMA CO., LTD.

      I-MAB BIOPHARMA US LIMITED

<120> NOVEL ANTI-CD47 ANTIBODIES AND USES THEREOF

<130> FE00494PCT

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> PCT/CN2020/122188
<151> 2020-10-20

<150> PCT/CN2020/120869
<151> 2020-10-14

<160> 55

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 1
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Arg Ala
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Gly Ser Asn Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 2
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ala
            20                  25                  30          
Gly Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Asn Gln Ala Ser Thr Arg Ala Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Thr Pro Pro Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys
    


<210> 3
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Arg Ala
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Gly Ser Asn Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445 


<210> 4
<211> 220
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ala
            20                  25                  30          
Gly Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Asn Gln Ala Ser Thr Arg Ala Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Thr Pro Pro Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 220 


<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Arg Ala Trp Met Asn
 1               5  


<210> 6
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15      
Val Lys Gly
            


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Ser Asn Arg Ala Phe Asp Ile
 1               5          


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Lys Ser Ser Gln Ser Val Leu Tyr Ala Gly Asn Asn Arg Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Gln Ala Ser Thr Arg Ala Ser
 1               5          


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Gln Gln Tyr Tyr Thr Pro Pro Leu Ala
 1               5                  


<210> 11
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Arg Ala
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Gly Ser Asn Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ala
        115             


<210> 12
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ala
            20                  25                  30          
Gly Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Asn Gln Ala Ser Thr Arg Ala Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Thr Pro Pro Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys
    


<210> 13
<211> 445
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Arg Ala
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Gly Ser Asn Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
        435                 440                 445 


<210> 14
<211> 220
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ala
            20                  25                  30          
Gly Asn Asn Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Asn Gln Ala Ser Thr Arg Ala Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Ile
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Ile Tyr Tyr Cys Gln Gln
                85                  90                  95      
Tyr Tyr Thr Pro Pro Leu Ala Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp
        115                 120                 125             
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
    130                 135                 140                 
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu
145                 150                 155                 160 
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp
                165                 170                 175     
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr
            180                 185                 190         
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser
        195                 200                 205             
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
    210                 215                 220 


<210> 15
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Arg Ala Trp Met Asn
 1               5  


<210> 16
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp Tyr Ala Ala Pro
 1               5                  10                  15      
Val Lys Gly
            


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Ser Asn Arg Ala Phe Asp Ile
 1               5          


<210> 18
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Lys Ser Ser Gln Ser Val Leu Tyr Ala Gly Asn Asn Arg Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Gln Ala Ser Thr Arg Ala Ser
 1               5          


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Gln Gln Tyr Tyr Thr Pro Pro Leu Ala
 1               5                  


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Gly Leu Thr Phe Glu Arg Ala
 1               5          


<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Lys Arg Lys Thr Asp Gly Glu Thr
 1               5              


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Ser Asn Arg Ala Phe Asp Ile
 1               5          


<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Lys Ser Ser Gln Ser Val Leu Tyr Ala Gly Asn Asn Arg Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Gln Ala Ser Thr Arg Ala Ser
 1               5          


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Gln Gln Tyr Tyr Thr Pro Pro Leu Ala
 1               5                  


<210> 27
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Gly Leu Thr Phe Glu Arg Ala Trp
 1               5              


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr
 1               5                  10  


<210> 29
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Ala Gly Ser Asn Arg Ala Phe Asp Ile
 1               5                  


<210> 30
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Gln Ser Val Leu Tyr Ala Gly Asn Asn Arg Asn Tyr
 1               5                  10          


<210> 31
<211> 2
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Gln Ala
 1      


<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 32
Gln Gln Tyr Tyr Thr Pro Pro Leu Ala
 1               5                  


<210> 33
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 33
Gly Leu Thr Phe Glu Arg Ala Trp Met Asn
 1               5                  10  


<210> 34
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 34
Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp
 1               5                  10          


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 35
Ser Asn Arg Ala Phe Asp Ile
 1               5          


<210> 36
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 36
Lys Ser Ser Gln Ser Val Leu Tyr Ala Gly Asn Asn Arg Asn Tyr Leu
 1               5                  10                  15      
Ala
    


<210> 37
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 37
Gln Ala Ser Thr Arg Ala Ser
 1               5          


<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 38
Gln Gln Tyr Tyr Thr Pro Pro Leu Ala
 1               5                  


<210> 39
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 39
Glu Arg Ala Trp Met Asn
 1               5      


<210> 40
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 40
Trp Val Gly Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp
 1               5                  10                  15  


<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 41
Ala Gly Ser Asn Arg Ala Phe Asp
 1               5              


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 42
Leu Tyr Ala Gly Asn Asn Arg Asn Tyr Leu Ala Trp Tyr
 1               5                  10              


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Leu Leu Ile Asn Gln Ala Ser Thr Arg Ala
 1               5                  10  


<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
Gln Gln Tyr Tyr Thr Pro Pro Leu
 1               5              


<210> 45
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
gaggtgcagc tggtggagag cggaggcgga ctcgtgaagc ctggaggaag cctgaggctg 60
tcctgtgccg cttccggcct caccttcgag cgggcttgga tgaactgggt gaggcaggcc 120
cctggaaagg gcctggaatg ggtgggccgg atcaagagga aaacagatgg cgagaccacc 180
gattacgccg ctcccgtgaa gggccggttt agcatctcca gggacgactc caagaacacc 240
ctgtatctgc agatgaacag cctgaagacc gaggacaccg ctgtgtacta ctgcgctggc 300
agcaacaggg cctttgatat ctggggccag ggcaccatgg tgacagtgtc ctcc       354

<210> 46
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
gacatcgtga tgacccagtc ccctgattcc ctggccgtga gcctgggcga aagggctacc 60
atcaactgca agtcctccca gagcgtgctg tacgccggca acaaccggaa ctatctggct 120
tggtaccagc agaagcccgg ccagcctccc aagctgctga tcaaccaggc tagcaccagg 180
gcttccggcg tgcctgatag gttcagcggc tccggctccg gcaccgagtt taccctgatc 240
atctcctccc tgcaggccga ggatgtggcc atctactact gccagcagta ctacacccct 300
cctctggcct ttggcggcgg caccaagctg gagatcaag                        339

<210> 47
<211> 1338
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
gaggtgcagc tggtggagag cggaggcgga ctcgtgaagc ctggaggaag cctgaggctg 60
tcctgtgccg cttccggcct caccttcgag cgggcttgga tgaactgggt gaggcaggcc 120
cctggaaagg gcctggaatg ggtgggccgg atcaagagga aaacagatgg cgagaccacc 180
gattacgccg ctcccgtgaa gggccggttt agcatctcca gggacgactc caagaacacc 240
ctgtatctgc agatgaacag cctgaagacc gaggacaccg ctgtgtacta ctgcgctggc 300
agcaacaggg cctttgatat ctggggccag ggcaccatgg tgacagtgtc ctccgcctcc 360
acaaagggac cttccgtgtt ccctctggcc ccttgttccc ggtccacctc cgaaagcacc 420
gctgctctgg gctgcctcgt caaggactac ttccctgagc ccgtgaccgt gagctggaac 480
tccggcgctc tgacaagcgg cgtgcatacc ttccctgccg tgctgcaaag cagcggcctg 540
tatagcctga gcagcgtggt gaccgtgcct agctcctccc tgggcaccaa aacctacacc 600
tgcaatgtgg accacaagcc ttccaacacc aaggtggaca agcgggtcga gtccaagtac 660
ggccctcctt gccctccctg ccccgctccc gagtttctgg gaggacccag cgtgttcctc 720
ttccccccta agcccaagga caccctgatg atcagccgga cacctgaggt cacctgcgtg 780
gtggtggatg tgagccaaga ggatcctgag gtccagttca actggtacgt ggacggagtg 840
gaggtgcata acgccaagac caagcctcgg gaggagcagt tcaactccac ctatagggtg 900
gtgagcgtgc tcacagtgct ccaccaggac tggctgaacg gcaaggagta caaatgcaag 960
gtgtccaaca agggactccc cagcagcatc gaaaagacca tcagcaaggc caaaggccag 1020
cccagggaac cccaggtgta cacactgccc ccctcccaag aggaaatgac caagaatcag 1080
gtgtccctga cctgcctggt gaaaggcttt taccccagcg acatcgctgt cgagtgggag 1140
agcaacggcc agcctgagaa taactataag accacccccc ccgtgctgga tagcgacgga 1200
tccttcttcc tctactcccg gctgaccgtg gataagtccc ggtggcagga gggcaacgtg 1260
ttcagctgct ccgtcatgca cgaggccctg cataaccact acacccagaa gtccctgagc 1320
ctgtccctgg gcaagtga                                               1338

<210> 48
<211> 663
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
gacatcgtga tgacccagtc ccctgattcc ctggccgtga gcctgggcga aagggctacc 60
atcaactgca agtcctccca gagcgtgctg tacgccggca acaaccggaa ctatctggct 120
tggtaccagc agaagcccgg ccagcctccc aagctgctga tcaaccaggc tagcaccagg 180
gcttccggcg tgcctgatag gttcagcggc tccggctccg gcaccgagtt taccctgatc 240
atctcctccc tgcaggccga ggatgtggcc atctactact gccagcagta ctacacccct 300
cctctggcct ttggcggcgg caccaagctg gagatcaaga ggacagtggc cgccccctcc 360
gtgttcattt tccctccctc cgacgagcag ctgaagtccg gcaccgcctc cgtggtgtgc 420
ctgctgaaca acttctaccc cagggaggcc aaggtgcagt ggaaggtgga caatgccctg 480
cagagcggca acagccagga gagcgtcacc gagcaggact ccaaagacag cacatacagc 540
ctgtccagca ccctgaccct gtccaaggct gactatgaga agcacaaggt gtacgcctgc 600
gaggtgaccc accagggact gagctcccct gtgaccaagt ccttcaaccg gggagagtgc 660
tga                                                               663

<210> 49
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
cgggcttgga tgaac                                                  15

<210> 50
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
cggatcaaga ggaaaacaga tggcgagacc accgattacg ccgctcccgt gaagggc    57

<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
agcaacaggg cctttgatat c                                           21

<210> 52
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
aagtcctccc agagcgtgct gtacgccggc aacaaccgga actatctggc t          51

<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
caggctagca ccagggcttc c                                           21

<210> 54
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
cagcagtact acacccctcc tctggcc                                     27

<210> 55
<211> 444
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Glu Arg Ala
            20                  25                  30          
Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Gly Arg Ile Lys Arg Lys Thr Asp Gly Glu Thr Thr Asp Tyr Ala Ala
    50                  55                  60                  
Pro Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Gly Ser Asn Arg Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190         
Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser
        195                 200                 205             
Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu
    290                 295                 300                 
Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys
                325                 330                 335     
Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser
            340                 345                 350         
Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln
                405                 410                 415     
Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 
