                         SEQUENCE LISTING

<110>  Institut Pasteur
       Invectys
 
<120>  Chimeric constructs useful in vaccination and cancer therapy

<130>  B14597WO

<140>  PCT/EP2021/078721
<141>  2021-10-15

<150>  EP20306229.4
<151>  2020-10-16

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Oligomerization domain of FCN3

<400>  1

Gln Glu His Pro Ser Cys Pro Gly Pro Arg Glu Leu Glu Ala Ser Lys 
1               5                   10                  15      


Val Val Leu Leu Pro Ser Cys Pro 
            20                  


<210>  2
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagen domain of FCN3

<400>  2

Gly Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly 
1               5                   10                  15      


Pro Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro 
            20                  25                  30          


Arg Gly 
        


<210>  3
<211>  999
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FCN3-ILT2-V5 construct


<220>
<221>  CDS
<222>  (13)..(987)

<400>  3
ggatccgccgc c atg gac ctc ctg tgg atc ttg ccc tcc ctg tgg ctt ctc        51
              Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu          
              1               5                   10                       

ctg ctt ggt ggc cct gcc tgc ctg aaa acc cag gag cac cct tca tgc         99
Leu Leu Gly Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys           
    15                  20                  25                            

cct gga ccc agg gaa ctc gaa gct agc aaa gtg gtc ctg ctg ccc tct        147
Pro Gly Pro Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser           
30                  35                  40                  45            

tgt ccc gga gca cca gga agt cct ggc gag aag gga gcc cca ggt cct        195
Cys Pro Gly Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro           
                50                  55                  60                

cag ggc cca cct gga cca cca ggc aag atg ggc ccc aag ggt gag cca        243
Gln Gly Pro Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro           
            65                  70                  75                    

ggc ccc aga gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca cag        291
Gly Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln           
        80                  85                  90                        

aat tct ggc cat ctg cca aag ccc acc ctc tgg gcc gag cct ggc agt        339
Asn Ser Gly His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser           
    95                  100                 105                           

gtg atc aca cag ggt agc cca gtc act ctg cgg tgc cag ggt gga cag        387
Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln           
110                 115                 120                 125           

gaa acc cag gaa tat cgc ttg tat aga gag aag aaa acc gct ccc tgg        435
Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Pro Trp           
                130                 135                 140               

att act aga atc cca cag gag ctg gtg aag aaa ggc cag ttt cct att        483
Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile           
            145                 150                 155                   

cca tca atc acc tgg gag cac aca gga cgc tac cgg tgc tac tat ggc        531
Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Arg Cys Tyr Tyr Gly           
        160                 165                 170                       

agt gat aca gca gga agg tct gag tca tcc gac cct ctt gag ctg gtg        579
Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val           
    175                 180                 185                           

gtt act ggc gcc tac atc aag ccc act ctg agc gca cag ccc tcc cca        627
Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro           
190                 195                 200                 205           

gtg gtg aac agc ggt ggc aat gtt acc ttg cag tgt gat tcc cag gtc        675
Val Val Asn Ser Gly Gly Asn Val Thr Leu Gln Cys Asp Ser Gln Val           
                210                 215                 220               

gct ttt gac ggt ttc atc ctg tgt aaa gag ggc gaa gac gaa cat ccc        723
Ala Phe Asp Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro           
            225                 230                 235                   

cag tgc ctt aac tca cag cca cac gcc agg gga agt tcc agg gca att        771
Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile           
        240                 245                 250                       

ttc tcc gtg ggt cct gtc agt cct agc cgg cgc tgg tgg tac aga tgt        819
Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys           
    255                 260                 265                           

tat gct tac gat agc aat tct ccc tac gaa tgg tct ctg cct agc gac        867
Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp           
270                 275                 280                 285           

ctt ctc gaa ctc ctg gtg ctc ggc gtt tca aag aaa ccc tct ggt acc        915
Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Gly Thr           
                290                 295                 300               

gca ggt agc gaa ggc aaa ccc atc cct aac cca ctg ctc ggt ctg gac        963
Ala Gly Ser Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp           
            305                 310                 315                   

tct acc cat cac cac cat cat cac tgatgactcg ag                          999
Ser Thr His His His His His His                                           
        320                 325                                           


<210>  4
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gly 
                85                  90                  95      


His Leu Pro Lys Pro Thr Leu Trp Ala Glu Pro Gly Ser Val Ile Thr 
            100                 105                 110         


Gln Gly Ser Pro Val Thr Leu Arg Cys Gln Gly Gly Gln Glu Thr Gln 
        115                 120                 125             


Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Thr Ala Pro Trp Ile Thr Arg 
    130                 135                 140                 


Ile Pro Gln Glu Leu Val Lys Lys Gly Gln Phe Pro Ile Pro Ser Ile 
145                 150                 155                 160 


Thr Trp Glu His Thr Gly Arg Tyr Arg Cys Tyr Tyr Gly Ser Asp Thr 
                165                 170                 175     


Ala Gly Arg Ser Glu Ser Ser Asp Pro Leu Glu Leu Val Val Thr Gly 
            180                 185                 190         


Ala Tyr Ile Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Asn 
        195                 200                 205             


Ser Gly Gly Asn Val Thr Leu Gln Cys Asp Ser Gln Val Ala Phe Asp 
    210                 215                 220                 


Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu 
225                 230                 235                 240 


Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val 
                245                 250                 255     


Gly Pro Val Ser Pro Ser Arg Arg Trp Trp Tyr Arg Cys Tyr Ala Tyr 
            260                 265                 270         


Asp Ser Asn Ser Pro Tyr Glu Trp Ser Leu Pro Ser Asp Leu Leu Glu 
        275                 280                 285             


Leu Leu Val Leu Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly Ser 
    290                 295                 300                 


Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr His 
305                 310                 315                 320 


His His His His His 
                325 


<210>  5
<211>  1002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FCN3-ILT4-V5 construct


<220>
<221>  CDS
<222>  (13)..(990)

<400>  5
ggatccgccg cc atg gac ctc ctg tgg atc ttg ccc tcc ctg tgg ctt ctc       51
              Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu         
              1               5                   10                      

ctg ctt ggt ggc cct gcc tgc ctg aaa acc cag gag cac cct tca tgc         99
Leu Leu Gly Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys           
    15                  20                  25                            

cct gga ccc agg gaa ctc gaa gct agc aaa gtg gtc ctg ctg ccc tct        147
Pro Gly Pro Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser           
30                  35                  40                  45            

tgt ccc gga gca cca gga agt cct ggc gag aag gga gcc cca ggt cct        195
Cys Pro Gly Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro           
                50                  55                  60                

cag ggc cca cct gga cca cca ggc aag atg ggc ccc aag ggt gag cca        243
Gln Gly Pro Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro           
            65                  70                  75                    

ggc ccc aga gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca cag        291
Gly Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln           
        80                  85                  90                        

aat tct cag aca ggc acc atc ccc aag ccc act ctg tgg gct gag cca        339
Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro           
    95                  100                 105                           

gac tct gtg atc acc cag gga agt ccc gtc act ctc agt tgt cag ggt        387
Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly           
110                 115                 120                 125           

agc ctt gaa gcc cag gag tac cgg ctg tac agg gag aag aaa tca gca        435
Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala           
                130                 135                 140               

tct tgg att aca cgg att aga cca gag ctt gtg aag aat ggc cag ttt        483
Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe           
            145                 150                 155                   

cac atc cca tcc atc acc tgg gaa cac aca gga aga tat ggc tgt cag        531
His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln           
        160                 165                 170                       

tat tac agc cgc gct cgg tgg tct gag ctt agt gac cct ctg gtg ctg        579
Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu           
    175                 180                 185                           

gtt atg aca gga gcc tac cca aaa ccc acc ctc tca gcc cag ccc agc        627
Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser           
190                 195                 200                 205           

cct gtt gtg act tca gga gga agg gtg acc ctg cag tgt gag tcc cag        675
Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln           
                210                 215                 220               

gtg gca ttt ggc ggc ttc att ctg tgc aag gaa gga gaa gat gaa cac        723
Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His           
            225                 230                 235                   

cca cag tgc ctg aac tcc cag ccc cat gcc aga ggc agc tcc cgc gct        771
Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala           
        240                 245                 250                       

atc ttc tcc gtg ggc cct gtg agc cct aat cgc agg tgg agc cat agg        819
Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg           
    255                 260                 265                           

tgc tac ggt tat gac ttg aac tct ccc tat gtc tgg tct tca ccc agt        867
Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser           
270                 275                 280                 285           

gat ctg ctg gag ctc ttg gtc cca ggt gtt tcc aag aaa cca tcc ggt        915
Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly           
                290                 295                 300               

acc gca ggt agc gaa ggc aaa ccc atc cct aac cca ctg ctc ggt ctg        963
Thr Ala Gly Ser Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu           
            305                 310                 315                   

gac tct acc cat cac cac cat cat cac tgatgactcg ag                     1002
Asp Ser Thr His His His His His His                                       
        320                 325                                           


<210>  6
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln 
                85                  90                  95      


Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val 
            100                 105                 110         


Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu 
        115                 120                 125             


Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile 
    130                 135                 140                 


Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro 
145                 150                 155                 160 


Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser 
                165                 170                 175     


Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr 
            180                 185                 190         


Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val 
        195                 200                 205             


Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe 
    210                 215                 220                 


Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys 
225                 230                 235                 240 


Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser 
                245                 250                 255     


Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly 
            260                 265                 270         


Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu 
        275                 280                 285             


Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly 
    290                 295                 300                 


Ser Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
305                 310                 315                 320 


His His His His His His 
                325     


<210>  7
<211>  1044
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MuFAT4


<220>
<221>  CDS
<222>  (13)..(1032)

<400>  7
ggatccgccg cc atg cag tgg ccc acc ctg tgg gcc ttc agc ggc ctc ctg       51
              Met Gln Trp Pro Thr Leu Trp Ala Phe Ser Gly Leu Leu         
              1               5                   10                      

tgc ctt tgt ccc tcc cag gct ctc ggt cag gag aga gga gcc tgc cct         99
Cys Leu Cys Pro Ser Gln Ala Leu Gly Gln Glu Arg Gly Ala Cys Pro           
    15                  20                  25                            

gac gtc aag gtg gtc gga ttg ggc gct cag gat aaa gtt gtg gtg atc        147
Asp Val Lys Val Val Gly Leu Gly Ala Gln Asp Lys Val Val Val Ile           
30                  35                  40                  45            

cag tct tgt cca ggc ttt ccc ggt cct ccc gga cca aag ggc gaa cct        195
Gln Ser Cys Pro Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Glu Pro           
                50                  55                  60                

ggc agt cca gcc ggt cgg gga gag cgc ggt ttc cag ggc tca ccc ggt        243
Gly Ser Pro Ala Gly Arg Gly Glu Arg Gly Phe Gln Gly Ser Pro Gly           
            65                  70                  75                    

aaa atg ggc cct gca ggt tcc aag ggc gag cca ggc aca atg ggt cct        291
Lys Met Gly Pro Ala Gly Ser Lys Gly Glu Pro Gly Thr Met Gly Pro           
        80                  85                  90                        

cca gga gtg aag ggc gaa aaa ggc gat act ggt gca gcc gga ggt ggc        339
Pro Gly Val Lys Gly Glu Lys Gly Asp Thr Gly Ala Ala Gly Gly Gly           
    95                  100                 105                           

agt ggt ggc gga tct ggc gga ggt tca cag aat tct cag aca ggc acc        387
Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln Thr Gly Thr           
110                 115                 120                 125           

atc ccc aag ccc act ctg tgg gct gag cca gac tct gtg atc acc cag        435
Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val Ile Thr Gln           
                130                 135                 140               

gga agt ccc gtc act ctc agt tgt cag ggt agc ctt gaa gcc cag gag        483
Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala Gln Glu           
            145                 150                 155                   

tac cgg ctg tac agg gag aag aaa tca gca tct tgg att aca cgg att        531
Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr Arg Ile           
        160                 165                 170                       

aga cca gag ctt gtg aag aat ggc cag ttt cac atc cca tcc atc acc        579
Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro Ser Ile Thr           
    175                 180                 185                           

tgg gaa cac aca gga aga tat ggc tgt cag tat tac agc cgc gct cgg        627
Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg Ala Arg           
190                 195                 200                 205           

tgg tct gag ctt agt gac cct ctg gtg ctg gtt atg aca gga gcc tac        675
Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr Gly Ala Tyr           
                210                 215                 220               

cca aaa ccc acc ctc tca gcc cag ccc agc cct gtt gtg act tca gga        723
Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Thr Ser Gly           
            225                 230                 235                   

gga agg gtg acc ctg cag tgt gag tcc cag gtg gca ttt ggc ggc ttc        771
Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe Gly Gly Phe           
        240                 245                 250                       

att ctg tgc aag gaa gga gaa gat gaa cac cca cag tgc ctg aac tcc        819
Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu Asn Ser           
    255                 260                 265                           

cag ccc cat gcc aga ggc agc tcc cgc gct atc ttc tcc gtg ggc cct        867
Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val Gly Pro           
270                 275                 280                 285           

gtg agc cct aat cgc agg tgg agc cat agg tgc tac ggt tat gac ttg        915
Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr Asp Leu           
                290                 295                 300               

aac tct ccc tat gtc tgg tct tca ccc agt gat ctg ctg gag ctc ttg        963
Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu Glu Leu Leu           
            305                 310                 315                   

gtc cca ggt gtt tcc aag aaa cca tcc ggt acc gca ggt agc gaa gac       1011
Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly Ser Glu Asp           
        320                 325                 330                       

tat aag gac gat gat gac aag tgatgactcg ag                             1044
Tyr Lys Asp Asp Asp Asp Lys                                               
    335                 340                                               


<210>  8
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Gln Trp Pro Thr Leu Trp Ala Phe Ser Gly Leu Leu Cys Leu Cys 
1               5                   10                  15      


Pro Ser Gln Ala Leu Gly Gln Glu Arg Gly Ala Cys Pro Asp Val Lys 
            20                  25                  30          


Val Val Gly Leu Gly Ala Gln Asp Lys Val Val Val Ile Gln Ser Cys 
        35                  40                  45              


Pro Gly Phe Pro Gly Pro Pro Gly Pro Lys Gly Glu Pro Gly Ser Pro 
    50                  55                  60                  


Ala Gly Arg Gly Glu Arg Gly Phe Gln Gly Ser Pro Gly Lys Met Gly 
65                  70                  75                  80  


Pro Ala Gly Ser Lys Gly Glu Pro Gly Thr Met Gly Pro Pro Gly Val 
                85                  90                  95      


Lys Gly Glu Lys Gly Asp Thr Gly Ala Ala Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln Thr Gly Thr Ile Pro Lys 
        115                 120                 125             


Pro Thr Leu Trp Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro 
    130                 135                 140                 


Val Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu 
145                 150                 155                 160 


Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu 
                165                 170                 175     


Leu Val Lys Asn Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His 
            180                 185                 190         


Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu 
        195                 200                 205             


Leu Ser Asp Pro Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro 
    210                 215                 220                 


Thr Leu Ser Ala Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val 
225                 230                 235                 240 


Thr Leu Gln Cys Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys 
                245                 250                 255     


Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His 
            260                 265                 270         


Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro 
        275                 280                 285             


Asn Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro 
    290                 295                 300                 


Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly 
305                 310                 315                 320 


Val Ser Lys Lys Pro Ser Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp 
                325                 330                 335     


Asp Asp Asp Lys 
            340 


<210>  9
<211>  1014
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MuFBT4


<220>
<221>  CDS
<222>  (13)..(1002)

<400>  9
ggatccgccg cc atg gcc ctg ggc tcc gct gca ctc ttc gtg ctg acc ttg       51
              Met Ala Leu Gly Ser Ala Ala Leu Phe Val Leu Thr Leu         
              1               5                   10                      

aca gtc cac gct gcc gga act tgc cca gag ctt aag gtg ttg gac ctg         99
Thr Val His Ala Ala Gly Thr Cys Pro Glu Leu Lys Val Leu Asp Leu           
    15                  20                  25                            

gaa ggc tac aaa cag ctc acc atc ctg cag gga tgt cct gga ctt cca        147
Glu Gly Tyr Lys Gln Leu Thr Ile Leu Gln Gly Cys Pro Gly Leu Pro           
30                  35                  40                  45            

ggc gca gcc ggt ccc aag ggc gaa gcc gga gct aaa ggc gat cgc ggt        195
Gly Ala Ala Gly Pro Lys Gly Glu Ala Gly Ala Lys Gly Asp Arg Gly           
                50                  55                  60                

gag agt ggc ctg cct ggc att ccc ggc aaa gag ggt cct aca ggc cca        243
Glu Ser Gly Leu Pro Gly Ile Pro Gly Lys Glu Gly Pro Thr Gly Pro           
            65                  70                  75                    

aag ggt aac cag ggc gag aag ggt atc cgg ggt gaa aag ggc gac tca        291
Lys Gly Asn Gln Gly Glu Lys Gly Ile Arg Gly Glu Lys Gly Asp Ser           
        80                  85                  90                        

ggt ccc agc gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca cag        339
Gly Pro Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln           
    95                  100                 105                           

aat tct cag aca ggc acc atc ccc aag ccc act ctg tgg gct gag cca        387
Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro           
110                 115                 120                 125           

gac tct gtg atc acc cag gga agt ccc gtc act ctc agt tgt cag ggt        435
Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly           
                130                 135                 140               

agc ctt gaa gcc cag gag tac cgg ctg tac agg gag aag aaa tca gca        483
Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala           
            145                 150                 155                   

tct tgg att aca cgg att aga cca gag ctt gtg aag aat ggc cag ttt        531
Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe           
        160                 165                 170                       

cac atc cca tcc atc acc tgg gaa cac aca gga aga tat ggc tgt cag        579
His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln           
    175                 180                 185                           

tat tac agc cgc gct cgg tgg tct gag ctt agt gac cct ctg gtg ctg        627
Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu           
190                 195                 200                 205           

gtt atg aca gga gcc tac cca aaa ccc acc ctc tca gcc cag ccc agc        675
Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser           
                210                 215                 220               

cct gtt gtg act tca gga gga agg gtg acc ctg cag tgt gag tcc cag        723
Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln           
            225                 230                 235                   

gtg gca ttt ggc ggc ttc att ctg tgc aag gaa gga gaa gat gaa cac        771
Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His           
        240                 245                 250                       

cca cag tgc ctg aac tcc cag ccc cat gcc aga ggc agc tcc cgc gct        819
Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala           
    255                 260                 265                           

atc ttc tcc gtg ggc cct gtg agc cct aat cgc agg tgg agc cat agg        867
Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg           
270                 275                 280                 285           

tgc tac ggt tat gac ttg aac tct ccc tat gtc tgg tct tca ccc agt        915
Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser           
                290                 295                 300               

gat ctg ctg gag ctc ttg gtc cca ggt gtt tcc aag aaa cca tcc ggt        963
Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly           
            305                 310                 315                   

acc gca ggt agc gaa gac tat aag gac gat gat gac aag tgatgactcg ag     1014
Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys                       
        320                 325                 330                       


<210>  10
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Ala Leu Gly Ser Ala Ala Leu Phe Val Leu Thr Leu Thr Val His 
1               5                   10                  15      


Ala Ala Gly Thr Cys Pro Glu Leu Lys Val Leu Asp Leu Glu Gly Tyr 
            20                  25                  30          


Lys Gln Leu Thr Ile Leu Gln Gly Cys Pro Gly Leu Pro Gly Ala Ala 
        35                  40                  45              


Gly Pro Lys Gly Glu Ala Gly Ala Lys Gly Asp Arg Gly Glu Ser Gly 
    50                  55                  60                  


Leu Pro Gly Ile Pro Gly Lys Glu Gly Pro Thr Gly Pro Lys Gly Asn 
65                  70                  75                  80  


Gln Gly Glu Lys Gly Ile Arg Gly Glu Lys Gly Asp Ser Gly Pro Ser 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln 
            100                 105                 110         


Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val 
        115                 120                 125             


Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu 
    130                 135                 140                 


Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile 
145                 150                 155                 160 


Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro 
                165                 170                 175     


Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser 
            180                 185                 190         


Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr 
        195                 200                 205             


Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val 
    210                 215                 220                 


Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe 
225                 230                 235                 240 


Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys 
                245                 250                 255     


Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser 
            260                 265                 270         


Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly 
        275                 280                 285             


Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu 
    290                 295                 300                 


Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly 
305                 310                 315                 320 


Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 330 


<210>  11
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuF1T4


<220>
<221>  CDS
<222>  (13)..(1038)

<400>  11
ggatccgccg cc atg gag ctg agc gga gcc act atg gcc agg ggt ctg gca       51
              Met Glu Leu Ser Gly Ala Thr Met Ala Arg Gly Leu Ala         
              1               5                   10                      

gtg ctt ctc gtg ctg ttc ctg cac atc aag aac ctc cct gcc cag gca         99
Val Leu Leu Val Leu Phe Leu His Ile Lys Asn Leu Pro Ala Gln Ala           
    15                  20                  25                            

gcc gac acc tgc cca gaa gtg aaa gtc gtt ggc ttg gaa ggc tca gac        147
Ala Asp Thr Cys Pro Glu Val Lys Val Val Gly Leu Glu Gly Ser Asp           
30                  35                  40                  45            

aaa ctg aca atc ctt cgc ggc tgt ccc ggt ctc cca ggc gct ccc ggt        195
Lys Leu Thr Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly           
                50                  55                  60                

ccc aaa ggc gag gca ggt gtg att gga gaa aga ggc gaa aga ggc ttg        243
Pro Lys Gly Glu Ala Gly Val Ile Gly Glu Arg Gly Glu Arg Gly Leu           
            65                  70                  75                    

cca gga gct cca ggc aag gct ggc cct gtc gga cct aaa ggc gat cgg        291
Pro Gly Ala Pro Gly Lys Ala Gly Pro Val Gly Pro Lys Gly Asp Arg           
        80                  85                  90                        

ggt gag aag ggc atg agg ggt gag aag ggt gat gcc gga cag tct gga        339
Gly Glu Lys Gly Met Arg Gly Glu Lys Gly Asp Ala Gly Gln Ser Gly           
    95                  100                 105                           

ggt ggc agt ggt ggc gga tct ggc gga ggt tca cag aat tct cag aca        387
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln Thr           
110                 115                 120                 125           

ggc acc atc ccc aag ccc act ctg tgg gct gag cca gac tct gtg atc        435
Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val Ile           
                130                 135                 140               

acc cag gga agt ccc gtc act ctc agt tgt cag ggt agc ctt gaa gcc        483
Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala           
            145                 150                 155                   

cag gag tac cgg ctg tac agg gag aag aaa tca gca tct tgg att aca        531
Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr           
        160                 165                 170                       

cgg att aga cca gag ctt gtg aag aat ggc cag ttt cac atc cca tcc        579
Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro Ser           
    175                 180                 185                           

atc acc tgg gaa cac aca gga aga tat ggc tgt cag tat tac agc cgc        627
Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg           
190                 195                 200                 205           

gct cgg tgg tct gag ctt agt gac cct ctg gtg ctg gtt atg aca gga        675
Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr Gly           
                210                 215                 220               

gcc tac cca aaa ccc acc ctc tca gcc cag ccc agc cct gtt gtg act        723
Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Thr           
            225                 230                 235                   

tca gga gga agg gtg acc ctg cag tgt gag tcc cag gtg gca ttt ggc        771
Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe Gly           
        240                 245                 250                       

ggc ttc att ctg tgc aag gaa gga gaa gat gaa cac cca cag tgc ctg        819
Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu           
    255                 260                 265                           

aac tcc cag ccc cat gcc aga ggc agc tcc cgc gct atc ttc tcc gtg        867
Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val           
270                 275                 280                 285           

ggc cct gtg agc cct aat cgc agg tgg agc cat agg tgc tac ggt tat        915
Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr           
                290                 295                 300               

gac ttg aac tct ccc tat gtc tgg tct tca ccc agt gat ctg ctg gag        963
Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu Glu           
            305                 310                 315                   

ctc ttg gtc cca ggt gtt tcc aag aaa cca tcc ggt acc gca ggt agc       1011
Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly Ser           
        320                 325                 330                       

gaa gac tat aag gac gat gat gac aag tgatgactcg ag                     1050
Glu Asp Tyr Lys Asp Asp Asp Asp Lys                                       
    335                 340                                               


<210>  12
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Glu Leu Ser Gly Ala Thr Met Ala Arg Gly Leu Ala Val Leu Leu 
1               5                   10                  15      


Val Leu Phe Leu His Ile Lys Asn Leu Pro Ala Gln Ala Ala Asp Thr 
            20                  25                  30          


Cys Pro Glu Val Lys Val Val Gly Leu Glu Gly Ser Asp Lys Leu Thr 
        35                  40                  45              


Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly 
    50                  55                  60                  


Glu Ala Gly Val Ile Gly Glu Arg Gly Glu Arg Gly Leu Pro Gly Ala 
65                  70                  75                  80  


Pro Gly Lys Ala Gly Pro Val Gly Pro Lys Gly Asp Arg Gly Glu Lys 
                85                  90                  95      


Gly Met Arg Gly Glu Lys Gly Asp Ala Gly Gln Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln Thr Gly Thr Ile 
        115                 120                 125             


Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val Ile Thr Gln Gly 
    130                 135                 140                 


Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr 
145                 150                 155                 160 


Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg 
                165                 170                 175     


Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro Ser Ile Thr Trp 
            180                 185                 190         


Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp 
        195                 200                 205             


Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr Gly Ala Tyr Pro 
    210                 215                 220                 


Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Thr Ser Gly Gly 
225                 230                 235                 240 


Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe Gly Gly Phe Ile 
                245                 250                 255     


Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln 
            260                 265                 270         


Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val 
        275                 280                 285             


Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn 
    290                 295                 300                 


Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu Glu Leu Leu Val 
305                 310                 315                 320 


Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly Ser Glu Asp Tyr 
                325                 330                 335     


Lys Asp Asp Asp Asp Lys 
            340         


<210>  13
<211>  1011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuF2T4


<220>
<221>  CDS
<222>  (13)..(999)

<400>  13
ggatccgccg cc atg gag ctg gac agg gcc gtg ggc gtg ctg gga gca gcc       51
              Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala         
              1               5                   10                      

acc ctg ttg ctc agc ttc ctg ggc atg gcc tgg gct ctt cag gca gcc         99
Thr Leu Leu Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala           
    15                  20                  25                            

gat act tgc ccc gaa gtc aag atg gtc ggc ctg gag ggc tca gat aaa        147
Asp Thr Cys Pro Glu Val Lys Met Val Gly Leu Glu Gly Ser Asp Lys           
30                  35                  40                  45            

ctc act atc ctg cgg ggt tgt cca ggc ttg cca ggt gcc cca ggt cca        195
Leu Thr Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro           
                50                  55                  60                

aag ggt gaa gcc ggt acc aac ggc aaa cgc ggt gag aga ggt cct ccc        243
Lys Gly Glu Ala Gly Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Pro           
            65                  70                  75                    

ggt cca ccc gga aaa gct ggt cct cca ggc cct aat ggt gct ccc gga        291
Gly Pro Pro Gly Lys Ala Gly Pro Pro Gly Pro Asn Gly Ala Pro Gly           
        80                  85                  90                        

gag cca gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca cag aat        339
Glu Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn           
    95                  100                 105                           

tct cag aca ggc acc atc ccc aag ccc act ctg tgg gct gag cca gac        387
Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp           
110                 115                 120                 125           

tct gtg atc acc cag gga agt ccc gtc act ctc agt tgt cag ggt agc        435
Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser           
                130                 135                 140               

ctt gaa gcc cag gag tac cgg ctg tac agg gag aag aaa tca gca tct        483
Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser           
            145                 150                 155                   

tgg att aca cgg att aga cca gag ctt gtg aag aat ggc cag ttt cac        531
Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His           
        160                 165                 170                       

atc cca tcc atc acc tgg gaa cac aca gga aga tat ggc tgt cag tat        579
Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr           
    175                 180                 185                           

tac agc cgc gct cgg tgg tct gag ctt agt gac cct ctg gtg ctg gtt        627
Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val           
190                 195                 200                 205           

atg aca gga gcc tac cca aaa ccc acc ctc tca gcc cag ccc agc cct        675
Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro           
                210                 215                 220               

gtt gtg act tca gga gga agg gtg acc ctg cag tgt gag tcc cag gtg        723
Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val           
            225                 230                 235                   

gca ttt ggc ggc ttc att ctg tgc aag gaa gga gaa gat gaa cac cca        771
Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro           
        240                 245                 250                       

cag tgc ctg aac tcc cag ccc cat gcc aga ggc agc tcc cgc gct atc        819
Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile           
    255                 260                 265                           

ttc tcc gtg ggc cct gtg agc cct aat cgc agg tgg agc cat agg tgc        867
Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys           
270                 275                 280                 285           

tac ggt tat gac ttg aac tct ccc tat gtc tgg tct tca ccc agt gat        915
Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp           
                290                 295                 300               

ctg ctg gag ctc ttg gtc cca ggt gtt tcc aag aaa cca tcc ggt acc        963
Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr           
            305                 310                 315                   

gca ggt agc gaa gac tat aag gac gat gat gac aag tgatgactcg ag         1011
Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys                           
        320                 325                                           


<210>  14
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Glu Leu Asp Arg Ala Val Gly Val Leu Gly Ala Ala Thr Leu Leu 
1               5                   10                  15      


Leu Ser Phe Leu Gly Met Ala Trp Ala Leu Gln Ala Ala Asp Thr Cys 
            20                  25                  30          


Pro Glu Val Lys Met Val Gly Leu Glu Gly Ser Asp Lys Leu Thr Ile 
        35                  40                  45              


Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Pro Gly Pro Lys Gly Glu 
    50                  55                  60                  


Ala Gly Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Pro Gly Pro Pro 
65                  70                  75                  80  


Gly Lys Ala Gly Pro Pro Gly Pro Asn Gly Ala Pro Gly Glu Pro Gly 
                85                  90                  95      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln Thr 
            100                 105                 110         


Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val Ile 
        115                 120                 125             


Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala 
    130                 135                 140                 


Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr 
145                 150                 155                 160 


Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro Ser 
                165                 170                 175     


Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg 
            180                 185                 190         


Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr Gly 
        195                 200                 205             


Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val Thr 
    210                 215                 220                 


Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe Gly 
225                 230                 235                 240 


Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys Leu 
                245                 250                 255     


Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser Val 
            260                 265                 270         


Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr 
        275                 280                 285             


Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu Glu 
    290                 295                 300                 


Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly Ser 
305                 310                 315                 320 


Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 


<210>  15
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuF3T4F


<220>
<221>  CDS
<222>  (13)..(954)

<400>  15
ggatccgccg cc atg gac ctc ctg tgg atc ttg ccc tcc ctg tgg ctt ctc       51
              Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu         
              1               5                   10                      

ctg ctt ggt ggc cct gcc tgc ctg aaa acc cag gag cac cct tca tgc         99
Leu Leu Gly Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys           
    15                  20                  25                            

cct gga ccc agg gaa ctc gaa gct agc aaa gtg gtc ctg ctg ccc tct        147
Pro Gly Pro Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser           
30                  35                  40                  45            

tgt ccc gga gca cca gga agt cct ggc gag aag gga gcc cca ggt cct        195
Cys Pro Gly Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro           
                50                  55                  60                

cag ggc cca cct gga cca cca ggc aag atg ggc ccc aag ggt gag cca        243
Gln Gly Pro Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro           
            65                  70                  75                    

ggc ccc aga gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca cag        291
Gly Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln           
        80                  85                  90                        

aat tct cag aca ggc acc atc ccc aag ccc act ctg tgg gct gag cca        339
Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro           
    95                  100                 105                           

gac tct gtg atc acc cag gga agt ccc gtc act ctc agt tgt cag ggt        387
Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly           
110                 115                 120                 125           

agc ctt gaa gcc cag gag tac cgg ctg tac agg gag aag aaa tca gca        435
Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala           
                130                 135                 140               

tct tgg att aca cgg att aga cca gag ctt gtg aag aat ggc cag ttt        483
Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe           
            145                 150                 155                   

cac atc cca tcc atc acc tgg gaa cac aca gga aga tat ggc tgt cag        531
His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln           
        160                 165                 170                       

tat tac agc cgc gct cgg tgg tct gag ctt agt gac cct ctg gtg ctg        579
Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu           
    175                 180                 185                           

gtt atg aca gga gcc tac cca aaa ccc acc ctc tca gcc cag ccc agc        627
Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser           
190                 195                 200                 205           

cct gtt gtg act tca gga gga agg gtg acc ctg cag tgt gag tcc cag        675
Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln           
                210                 215                 220               

gtg gca ttt ggc ggc ttc att ctg tgc aag gaa gga gaa gat gaa cac        723
Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His           
            225                 230                 235                   

cca cag tgc ctg aac tcc cag ccc cat gcc aga ggc agc tcc cgc gct        771
Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala           
        240                 245                 250                       

atc ttc tcc gtg ggc cct gtg agc cct aat cgc agg tgg agc cat agg        819
Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg           
    255                 260                 265                           

tgc tac ggt tat gac ttg aac tct ccc tat gtc tgg tct tca ccc agt        867
Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser           
270                 275                 280                 285           

gat ctg ctg gag ctc ttg gtc cca ggt gtt tcc aag aaa cca tcc ggt        915
Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly           
                290                 295                 300               

acc gca ggt agc gaa gac tat aag gac gat gat gac aag tgatgactcg ag      966
Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys                       
            305                 310                                       


<210>  16
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Gln 
                85                  90                  95      


Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser Val 
            100                 105                 110         


Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu Glu 
        115                 120                 125             


Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp Ile 
    130                 135                 140                 


Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile Pro 
145                 150                 155                 160 


Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser 
                165                 170                 175     


Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met Thr 
            180                 185                 190         


Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val Val 
        195                 200                 205             


Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala Phe 
    210                 215                 220                 


Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln Cys 
225                 230                 235                 240 


Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe Ser 
                245                 250                 255     


Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr Gly 
            260                 265                 270         


Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu Leu 
        275                 280                 285             


Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala Gly 
    290                 295                 300                 


Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
305                 310                 


<210>  17
<211>  1110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuF3para7


<220>
<221>  CDS
<222>  (13)..(1098)

<400>  17
ggatccgccg cc atg gac ctc ctg tgg atc ttg ccc tcc ctg tgg ctt ctc       51
              Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu         
              1               5                   10                      

ctg ctt ggt ggc cct gcc tgc ctg aaa acc cag gag cac cct tca tgc         99
Leu Leu Gly Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys           
    15                  20                  25                            

cct ggt ccc agg gaa ctc gaa gct agc aaa gtg gtc ctg ctg ccc tct        147
Pro Gly Pro Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser           
30                  35                  40                  45            

tgt ccc gga gca cca gga agt cct ggc gag aag ggt gcc cca ggt cct        195
Cys Pro Gly Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro           
                50                  55                  60                

cag ggc cca cct gga cca cca ggc aag atg ggc ccc aag ggt gag cca        243
Gln Gly Pro Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro           
            65                  70                  75                    

ggc ccc aga gga ggt ggc agt ggt ggc gga tct ggc ggt ggt tca cag        291
Gly Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln           
        80                  85                  90                        

aat tct gat gtc ctg atg aca cag atc cca ttt agc ctg cct gtc tcc        339
Asn Ser Asp Val Leu Met Thr Gln Ile Pro Phe Ser Leu Pro Val Ser           
    95                  100                 105                           

ctg ggt gat cag gcc agc att agc tgt cgc tcc tcc cag tcc atc gtt        387
Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val           
110                 115                 120                 125           

cac cgg tct ggc aac act tat ctg gaa tgg tac ctc cag aaa ccc ggc        435
His Arg Ser Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly           
                130                 135                 140               

cag tcc cct aag ctc ctt att tac aaa gtg agc aat cgc ttt tct gga        483
Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly           
            145                 150                 155                   

gtg cct gat aga ttc tca gga agt ggt tca ggt act gac ttc acc ctt        531
Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu           
        160                 165                 170                       

aag att agc cag gtt gag gcc gag gat ctt ggt gtg tat tac tgc ttt        579
Lys Ile Ser Gln Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe           
    175                 180                 185                           

cag ggc agt cac ctt cct ccc aca ttt ggc ggc ggc aca act ctg gag        627
Gln Gly Ser His Leu Pro Pro Thr Phe Gly Gly Gly Thr Thr Leu Glu           
190                 195                 200                 205           

atc aaa ggt ggt gga ggc agc ggt gga ggt gga agt ggc ggt ggc ggc        675
Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly           
                210                 215                 220               

tca cag gtg cag ttg cag cag ccc ggc gcc gaa ctg gtc aga ccg ggc        723
Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly           
            225                 230                 235                   

tcc tct gtg aag ctg tca tgc aag gct agt ggc tat acc ttc acc gac        771
Ser Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp           
        240                 245                 250                       

tat tgg atg gat tgg gtt aag cag cgg cca ggt cag gga ctg gaa tgg        819
Tyr Trp Met Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp           
    255                 260                 265                           

att ggc acc att tat ccc agc gac agt tct act cac tac aac cag gag        867
Ile Gly Thr Ile Tyr Pro Ser Asp Ser Ser Thr His Tyr Asn Gln Glu           
270                 275                 280                 285           

ttc aaa ggc aag gct aca atg aca gtg gac aag tcc agt tct aca gcc        915
Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala           
                290                 295                 300               

tac atg cac ttg tct agc ctc aca tca gag gat tcc gca gtg tac tat        963
Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr           
            305                 310                 315                   

tgt gca agg gaa ggc ctg gct ggt gtg ttt tac ttc gac tac tgg gga       1011
Cys Ala Arg Glu Gly Leu Ala Gly Val Phe Tyr Phe Asp Tyr Trp Gly           
        320                 325                 330                       

cag ggc acc acc ttg act gtt agc tcc ggt acc gca ggt agc gaa gac       1059
Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Thr Ala Gly Ser Glu Asp           
    335                 340                 345                           

tat aag gac gat gat gac aag cat cac cac cat cat cac tgatgactcg ag     1110
Tyr Lys Asp Asp Asp Asp Lys His His His His His His                       
350                 355                 360                               


<210>  18
<211>  362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Met Thr Gln Ile Pro Phe Ser Leu Pro Val Ser Leu Gly Asp 
            100                 105                 110         


Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Arg Ser 
        115                 120                 125             


Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
    130                 135                 140                 


Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
145                 150                 155                 160 


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
                165                 170                 175     


Gln Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
            180                 185                 190         


His Leu Pro Pro Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys Gly 
        195                 200                 205             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
    210                 215                 220                 


Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser Ser Val 
225                 230                 235                 240 


Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Trp Met 
                245                 250                 255     


Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Thr 
            260                 265                 270         


Ile Tyr Pro Ser Asp Ser Ser Thr His Tyr Asn Gln Glu Phe Lys Gly 
        275                 280                 285             


Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met His 
    290                 295                 300                 


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
305                 310                 315                 320 


Glu Gly Leu Ala Gly Val Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
                325                 330                 335     


Thr Leu Thr Val Ser Ser Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp 
            340                 345                 350         


Asp Asp Asp Lys His His His His His His 
        355                 360         


<210>  19
<211>  1869
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuF3Calif


<220>
<221>  CDS
<222>  (13)..(1857)

<400>  19
ggatccgccg cc atg gac ctc ctg tgg atc ttg ccc tcc ctg tgg ctt ctc       51
              Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu         
              1               5                   10                      

ctg ctt ggt ggc cct gcc tgc ctg aaa acc cag gag cac cct tca tgc         99
Leu Leu Gly Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys           
    15                  20                  25                            

cct gga ccc agg gaa ctc gaa gct agc aaa gtg gtc ctg ctg ccc tct        147
Pro Gly Pro Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser           
30                  35                  40                  45            

tgt ccc gga gca cca gga agt cct ggc gag aag gga gcc cca ggt cct        195
Cys Pro Gly Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro           
                50                  55                  60                

cag ggc cca cct gga cca cca ggc aag atg ggc ccc aag ggt gag cca        243
Gln Gly Pro Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro           
            65                  70                  75                    

ggc ccc aga gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca gac        291
Gly Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp           
        80                  85                  90                        

act ctc tgc att ggc tat cac gca aac aat agc aca gat act gtg gac        339
Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val Asp           
    95                  100                 105                           

acc gtc ttg gag aag aac gtg acc gtg act cat tcc gtc aac ctc ctg        387
Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu Leu           
110                 115                 120                 125           

gag gac aaa cat aac gga aaa ctg tgt aag ttg cgg ggc gtt gcc cca        435
Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val Ala Pro           
                130                 135                 140               

ctt cac ctg ggt aaa tgc aac att gcc gga tgg att ctg gga aat cct        483
Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly Asn Pro           
            145                 150                 155                   

gaa tgc gag tct ctc tct aca gct agt tca tgg tcc tac atc gtt gag        531
Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile Val Glu           
        160                 165                 170                       

acc cca tct tcc gac aac ggc act tgt tat cca ggt gac ttc atc gac        579
Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe Ile Asp           
    175                 180                 185                           

tat gag gaa ctg agg gaa cag ctc tct agc gtc tca tcc ttt gag cgc        627
Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg           
190                 195                 200                 205           

ttc gaa att ttt cct aag acc tca tcc tgg cct aat cat gac agc aat        675
Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp Ser Asn           
                210                 215                 220               

aag gga gtg aca gca gcc tgc cca cac gct gga gct aag tca ttt tac        723
Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser Phe Tyr           
            225                 230                 235                   

aag aac ctg atc tgg ttg gtt aag aaa ggt aat agc tat ccc aaa ctt        771
Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro Lys Leu           
        240                 245                 250                       

tcc aag agt tac att aac gac aag gga aag gag gtg ctg gtc ctt tgg        819
Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val Leu Trp           
    255                 260                 265                           

ggt att cac cat ccc agc acc tcc gcc gat cag cag agc ctc tac cag        867
Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu Tyr Gln           
270                 275                 280                 285           

aat gcc gac aca tac gtg ttt gtc ggc agt tcc cgg tac tct aag aaa        915
Asn Ala Asp Thr Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser Lys Lys           
                290                 295                 300               

ttc aag cca gaa atc gct atc agg cca aag gtt aga gac cag gaa ggc        963
Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln Glu Gly           
            305                 310                 315                   

cgc atg aac tac tac tgg acc ctg gtg gag cca ggc gat aaa att act       1011
Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys Ile Thr           
        320                 325                 330                       

ttt gaa gca aca ggt aat ctc gtc gtg ccc aga tac gcc ttc gct atg       1059
Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe Ala Met           
    335                 340                 345                           

gaa cgg aat gcc gga agc gga atc att atc tcc gat acc cct gtg cac       1107
Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro Val His           
350                 355                 360                 365           

gat tgc aac acc aca tgt cag acc ccc aag ggc gct atc aac acc agc       1155
Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser           
                370                 375                 380               

ctg ccc ttt cag aac att cac cct att aca atc ggc aaa tgt ccc aaa       1203
Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys           
            385                 390                 395                   

tat gtg aag tcc act aaa ctg cgc ctg gct acc gga ctc cgg aac atc       1251
Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Ile           
        400                 405                 410                       

ccc tct att cag agc cgg ggt ctt ttc ggc gct atc gca gga ttt atc       1299
Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile           
    415                 420                 425                           

gag gga ggc tgg aca ggt atg gtc gat ggc tgg tat ggt tac cac cat       1347
Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His           
430                 435                 440                 445           

cag aat gag cag ggc agt ggc tat gct gcc gac ctg aaa tca act cag       1395
Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln           
                450                 455                 460               

aat gcc atc gac gag atc act aac aag gtg aac tca gtg atc gaa aag       1443
Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys           
            465                 470                 475                   

atg aat aca cag ttc acc gcc gtt ggt aaa gag ttc aac cac ctg gag       1491
Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu           
        480                 485                 490                       

aag aga atc gaa aat ttg aac aag aaa gtg gac gat ggc ttc ctg gat       1539
Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp           
    495                 500                 505                           

atc tgg acc tac aat gcc gag ctg ctt gtg ctc ttg gag aat gaa aga       1587
Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg           
510                 515                 520                 525           

acc ctg gat tat cat gat tct aac gtg aag aat ctt tac gag aaa gtg       1635
Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val           
                530                 535                 540               

agg tct cag ctc aag aac aat gcc aaa gag atc gga aat ggc tgc ttt       1683
Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe           
            545                 550                 555                   

gag ttc tac cac aag tgt gac aac act tgc atg gaa agt gtc aag aac       1731
Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn           
        560                 565                 570                       

ggc aca tac gat tat cct aaa tac agt gag gaa gcc aag ctg aat cgc       1779
Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg           
    575                 580                 585                           

gaa gaa att gat ggc gtc aaa ttg gag agc act agg ggt acc gca ggt       1827
Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Gly Thr Ala Gly           
590                 595                 600                 605           

agc gaa gac tat aag gac gat gat gac aag tgatgactcg ag                 1869
Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys                                       
                610                                                       


<210>  20
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asp Thr Leu Cys 
                85                  90                  95      


Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val Asp Thr Val Leu 
            100                 105                 110         


Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu Leu Glu Asp Lys 
        115                 120                 125             


His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val Ala Pro Leu His Leu 
    130                 135                 140                 


Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu 
145                 150                 155                 160 


Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile Val Glu Thr Pro Ser 
                165                 170                 175     


Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe Ile Asp Tyr Glu Glu 
            180                 185                 190         


Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile 
        195                 200                 205             


Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp Ser Asn Lys Gly Val 
    210                 215                 220                 


Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser Phe Tyr Lys Asn Leu 
225                 230                 235                 240 


Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro Lys Leu Ser Lys Ser 
                245                 250                 255     


Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val Leu Trp Gly Ile His 
            260                 265                 270         


His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu Tyr Gln Asn Ala Asp 
        275                 280                 285             


Thr Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser Lys Lys Phe Lys Pro 
    290                 295                 300                 


Glu Ile Ala Ile Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Met Asn 
305                 310                 315                 320 


Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys Ile Thr Phe Glu Ala 
                325                 330                 335     


Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe Ala Met Glu Arg Asn 
            340                 345                 350         


Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro Val His Asp Cys Asn 
        355                 360                 365             


Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu Pro Phe 
    370                 375                 380                 


Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr Val Lys 
385                 390                 395                 400 


Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg Asn Ile Pro Ser Ile 
                405                 410                 415     


Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly 
            420                 425                 430         


Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu 
        435                 440                 445             


Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile 
    450                 455                 460                 


Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr 
465                 470                 475                 480 


Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile 
                485                 490                 495     


Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr 
            500                 505                 510         


Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp 
        515                 520                 525             


Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Ser Gln 
    530                 535                 540                 


Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr 
545                 550                 555                 560 


His Lys Cys Asp Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr 
                565                 570                 575     


Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Glu Ile 
            580                 585                 590         


Asp Gly Val Lys Leu Glu Ser Thr Arg Gly Thr Ala Gly Ser Glu Asp 
        595                 600                 605             


Tyr Lys Asp Asp Asp Asp Lys 
    610                 


<210>  21
<211>  1026
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuMBLT4


<220>
<221>  CDS
<222>  (13)..(1014)

<400>  21
ggatccgccg cc atg agc ctg ttc ccc tcc ctc cca ctg ctt ctc ttg tca       51
              Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser         
              1               5                   10                      

atg gtg gcc gca agc tac agt gag acc gtc act tgc gaa gac gcc cag         99
Met Val Ala Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln           
    15                  20                  25                            

aag act tgt ccc gca gtg atc gct tgt tca tcc cct ggc atc aac ggc        147
Lys Thr Cys Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly           
30                  35                  40                  45            

ttt ccc ggc aaa gac ggc agg gat ggt acc aag ggc gaa aaa ggc gaa        195
Phe Pro Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu           
                50                  55                  60                

cct ggc cag ggt ttg cgc gga ctg cag ggc cct ccc gga aaa ctg ggt        243
Pro Gly Gln Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly           
            65                  70                  75                    

cca ccc gga aat cca ggt cca tca gga agt ccc gga ccc aaa ggc cag        291
Pro Pro Gly Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln           
        80                  85                  90                        

aag ggt gac cct ggc aaa tct gga ggt ggc agt ggt ggc gga tct ggc        339
Lys Gly Asp Pro Gly Lys Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly           
    95                  100                 105                           

gga ggt tca cag aat tct cag aca ggc acc atc ccc aag ccc act ctg        387
Gly Gly Ser Gln Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu           
110                 115                 120                 125           

tgg gct gag cca gac tct gtg atc acc cag gga agt ccc gtc act ctc        435
Trp Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu           
                130                 135                 140               

agt tgt cag ggt agc ctt gaa gcc cag gag tac cgg ctg tac agg gag        483
Ser Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu           
            145                 150                 155                   

aag aaa tca gca tct tgg att aca cgg att aga cca gag ctt gtg aag        531
Lys Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys           
        160                 165                 170                       

aat ggc cag ttt cac atc cca tcc atc acc tgg gaa cac aca gga aga        579
Asn Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg           
    175                 180                 185                           

tat ggc tgt cag tat tac agc cgc gct cgg tgg tct gag ctt agt gac        627
Tyr Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp           
190                 195                 200                 205           

cct ctg gtg ctg gtt atg aca gga gcc tac cca aaa ccc acc ctc tca        675
Pro Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser           
                210                 215                 220               

gcc cag ccc agc cct gtt gtg act tca gga gga agg gtg acc ctg cag        723
Ala Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln           
            225                 230                 235                   

tgt gag tcc cag gtg gca ttt ggc ggc ttc att ctg tgc aag gaa gga        771
Cys Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly           
        240                 245                 250                       

gaa gat gaa cac cca cag tgc ctg aac tcc cag ccc cat gcc aga ggc        819
Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly           
    255                 260                 265                           

agc tcc cgc gct atc ttc tcc gtg ggc cct gtg agc cct aat cgc agg        867
Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg           
270                 275                 280                 285           

tgg agc cat agg tgc tac ggt tat gac ttg aac tct ccc tat gtc tgg        915
Trp Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp           
                290                 295                 300               

tct tca ccc agt gat ctg ctg gag ctc ttg gtc cca ggt gtt tcc aag        963
Ser Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys           
            305                 310                 315                   

aaa cca tcc ggt acc gca ggt agc gaa gac tat aag gac gat gat gac       1011
Lys Pro Ser Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp           
        320                 325                 330                       

aag tgatgactcg ag                                                     1026
Lys                                                                       
                                                                          


<210>  22
<211>  334
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gln Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu 
        115                 120                 125             


Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln 
    130                 135                 140                 


Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser 
145                 150                 155                 160 


Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln 
                165                 170                 175     


Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys 
            180                 185                 190         


Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val 
        195                 200                 205             


Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro 
    210                 215                 220                 


Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser 
225                 230                 235                 240 


Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu 
                245                 250                 255     


His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg 
            260                 265                 270         


Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His 
        275                 280                 285             


Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro 
    290                 295                 300                 


Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser 
305                 310                 315                 320 


Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 330                 


<210>  23
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HuSPDT4


<220>
<221>  CDS
<222>  (13)..(957)

<400>  23
ggatccgccg cc atg ctg ctc ttc ctt ttg agc gcc ctg gtg ttg ctg acc       51
              Met Leu Leu Phe Leu Leu Ser Ala Leu Val Leu Leu Thr         
              1               5                   10                      

cag ccc ctt gga tat ctc gaa gct gag atg aag act tac tct cac agg         99
Gln Pro Leu Gly Tyr Leu Glu Ala Glu Met Lys Thr Tyr Ser His Arg           
    15                  20                  25                            

acc atg cca agt gcc tgc act ctg gtc atg tgt tct tcc gtc gag agc        147
Thr Met Pro Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu Ser           
30                  35                  40                  45            

ggc ctt cca gga cgg gac ggc tcc gtt ggc gaa cct gga cct aaa ggc        195
Gly Leu Pro Gly Arg Asp Gly Ser Val Gly Glu Pro Gly Pro Lys Gly           
                50                  55                  60                

gat aca ggt cca agt ggt cct ccc gga cca ccc ggt gtc ccc ggc cct        243
Asp Thr Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro           
            65                  70                  75                    

gca ggt cgc gag gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca        291
Ala Gly Arg Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser           
        80                  85                  90                        

cag aat tct cag aca ggc acc atc ccc aag ccc act ctg tgg gct gag        339
Gln Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu           
    95                  100                 105                           

cca gac tct gtg atc acc cag gga agt ccc gtc act ctc agt tgt cag        387
Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln           
110                 115                 120                 125           

ggt agc ctt gaa gcc cag gag tac cgg ctg tac agg gag aag aaa tca        435
Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser           
                130                 135                 140               

gca tct tgg att aca cgg att aga cca gag ctt gtg aag aat ggc cag        483
Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln           
            145                 150                 155                   

ttt cac atc cca tcc atc acc tgg gaa cac aca gga aga tat ggc tgt        531
Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys           
        160                 165                 170                       

cag tat tac agc cgc gct cgg tgg tct gag ctt agt gac cct ctg gtg        579
Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val           
    175                 180                 185                           

ctg gtt atg aca gga gcc tac cca aaa ccc acc ctc tca gcc cag ccc        627
Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro           
190                 195                 200                 205           

agc cct gtt gtg act tca gga gga agg gtg acc ctg cag tgt gag tcc        675
Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser           
                210                 215                 220               

cag gtg gca ttt ggc ggc ttc att ctg tgc aag gaa gga gaa gat gaa        723
Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu           
            225                 230                 235                   

cac cca cag tgc ctg aac tcc cag ccc cat gcc aga ggc agc tcc cgc        771
His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg           
        240                 245                 250                       

gct atc ttc tcc gtg ggc cct gtg agc cct aat cgc agg tgg agc cat        819
Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His           
    255                 260                 265                           

agg tgc tac ggt tat gac ttg aac tct ccc tat gtc tgg tct tca ccc        867
Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro           
270                 275                 280                 285           

agt gat ctg ctg gag ctc ttg gtc cca ggt gtt tcc aag aaa cca tcc        915
Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser           
                290                 295                 300               

ggt acc gca ggt agc gaa gac tat aag gac gat gat gac aag                957
Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys                   
            305                 310                 315                   

tgatgactcg ag                                                          969


<210>  24
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Leu Leu Phe Leu Leu Ser Ala Leu Val Leu Leu Thr Gln Pro Leu 
1               5                   10                  15      


Gly Tyr Leu Glu Ala Glu Met Lys Thr Tyr Ser His Arg Thr Met Pro 
            20                  25                  30          


Ser Ala Cys Thr Leu Val Met Cys Ser Ser Val Glu Ser Gly Leu Pro 
        35                  40                  45              


Gly Arg Asp Gly Ser Val Gly Glu Pro Gly Pro Lys Gly Asp Thr Gly 
    50                  55                  60                  


Pro Ser Gly Pro Pro Gly Pro Pro Gly Val Pro Gly Pro Ala Gly Arg 
65                  70                  75                  80  


Glu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gln Asn Ser 
                85                  90                  95      


Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp Ala Glu Pro Asp Ser 
            100                 105                 110         


Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser Cys Gln Gly Ser Leu 
        115                 120                 125             


Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys Lys Ser Ala Ser Trp 
    130                 135                 140                 


Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn Gly Gln Phe His Ile 
145                 150                 155                 160 


Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr Gly Cys Gln Tyr Tyr 
                165                 170                 175     


Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro Leu Val Leu Val Met 
            180                 185                 190         


Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala Gln Pro Ser Pro Val 
        195                 200                 205             


Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys Glu Ser Gln Val Ala 
    210                 215                 220                 


Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu Asp Glu His Pro Gln 
225                 230                 235                 240 


Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser Ser Arg Ala Ile Phe 
                245                 250                 255     


Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp Ser His Arg Cys Tyr 
            260                 265                 270         


Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser Ser Pro Ser Asp Leu 
        275                 280                 285             


Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys Pro Ser Gly Thr Ala 
    290                 295                 300                 


Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
305                 310                 315 


<210>  25
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PFT4


<220>
<221>  CDS
<222>  (13)..(1020)

<400>  25
ggatccgccg cc atg gac acc aga ggc gtg gca gca gcc atg cgc cca ctg       51
              Met Asp Thr Arg Gly Val Ala Ala Ala Met Arg Pro Leu         
              1               5                   10                      

gtc ctg ctt gtc gcc ttc ctc tgc act gct gcc cct gcc ttg gat act         99
Val Leu Leu Val Ala Phe Leu Cys Thr Ala Ala Pro Ala Leu Asp Thr           
    15                  20                  25                            

tgt cct gag gtg aag gtt gtg ggc ctg gag ggc agt gac aaa ctc tca        147
Cys Pro Glu Val Lys Val Val Gly Leu Glu Gly Ser Asp Lys Leu Ser           
30                  35                  40                  45            

atc ctt cgg gga tgt cca ggt ctg cct ggt gca gcc ggt cct aaa ggc        195
Ile Leu Arg Gly Cys Pro Gly Leu Pro Gly Ala Ala Gly Pro Lys Gly           
                50                  55                  60                

gag gct gga gcc gat ggc ccc aag ggt ggc cag ggt cct ccc gga gct        243
Glu Ala Gly Ala Asp Gly Pro Lys Gly Gly Gln Gly Pro Pro Gly Ala           
            65                  70                  75                    

cca ggc gaa ccc gga cct cca ggt ccc aaa ggc gat agg ggt gag aag        291
Pro Gly Glu Pro Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly Glu Lys           
        80                  85                  90                        

ggc gaa cct ggt ccc aag ggc gaa tcc gga ggt ggc agt ggt ggc gga        339
Gly Glu Pro Gly Pro Lys Gly Glu Ser Gly Gly Gly Ser Gly Gly Gly           
    95                  100                 105                           

tct ggc gga ggt tca cag aat tct cag aca ggc acc atc ccc aag ccc        387
Ser Gly Gly Gly Ser Gln Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro           
110                 115                 120                 125           

act ctg tgg gct gag cca gac tct gtg atc acc cag gga agt ccc gtc        435
Thr Leu Trp Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val           
                130                 135                 140               

act ctc agt tgt cag ggt agc ctt gaa gcc cag gag tac cgg ctg tac        483
Thr Leu Ser Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr           
            145                 150                 155                   

agg gag aag aaa tca gca tct tgg att aca cgg att aga cca gag ctt        531
Arg Glu Lys Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu           
        160                 165                 170                       

gtg aag aat ggc cag ttt cac atc cca tcc atc acc tgg gaa cac aca        579
Val Lys Asn Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr           
    175                 180                 185                           

gga aga tat ggc tgt cag tat tac agc cgc gct cgg tgg tct gag ctt        627
Gly Arg Tyr Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu           
190                 195                 200                 205           

agt gac cct ctg gtg ctg gtt atg aca gga gcc tac cca aaa ccc acc        675
Ser Asp Pro Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr           
                210                 215                 220               

ctc tca gcc cag ccc agc cct gtt gtg act tca gga gga agg gtg acc        723
Leu Ser Ala Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr           
            225                 230                 235                   

ctg cag tgt gag tcc cag gtg gca ttt ggc ggc ttc att ctg tgc aag        771
Leu Gln Cys Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys           
        240                 245                 250                       

gaa gga gaa gat gaa cac cca cag tgc ctg aac tcc cag ccc cat gcc        819
Glu Gly Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala           
    255                 260                 265                           

aga ggc agc tcc cgc gct atc ttc tcc gtg ggc cct gtg agc cct aat        867
Arg Gly Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn           
270                 275                 280                 285           

cgc agg tgg agc cat agg tgc tac ggt tat gac ttg aac tct ccc tat        915
Arg Arg Trp Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr           
                290                 295                 300               

gtc tgg tct tca ccc agt gat ctg ctg gag ctc ttg gtc cca ggt gtt        963
Val Trp Ser Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val           
            305                 310                 315                   

tcc aag aaa cca tcc ggt acc gca ggt agc gaa gac tat aag gac gat       1011
Ser Lys Lys Pro Ser Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp           
        320                 325                 330                       

gat gac aag tgatgactcg ag                                             1032
Asp Asp Lys                                                               
    335                                                                   


<210>  26
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Asp Thr Arg Gly Val Ala Ala Ala Met Arg Pro Leu Val Leu Leu 
1               5                   10                  15      


Val Ala Phe Leu Cys Thr Ala Ala Pro Ala Leu Asp Thr Cys Pro Glu 
            20                  25                  30          


Val Lys Val Val Gly Leu Glu Gly Ser Asp Lys Leu Ser Ile Leu Arg 
        35                  40                  45              


Gly Cys Pro Gly Leu Pro Gly Ala Ala Gly Pro Lys Gly Glu Ala Gly 
    50                  55                  60                  


Ala Asp Gly Pro Lys Gly Gly Gln Gly Pro Pro Gly Ala Pro Gly Glu 
65                  70                  75                  80  


Pro Gly Pro Pro Gly Pro Lys Gly Asp Arg Gly Glu Lys Gly Glu Pro 
                85                  90                  95      


Gly Pro Lys Gly Glu Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gln Asn Ser Gln Thr Gly Thr Ile Pro Lys Pro Thr Leu Trp 
        115                 120                 125             


Ala Glu Pro Asp Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Ser 
    130                 135                 140                 


Cys Gln Gly Ser Leu Glu Ala Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
145                 150                 155                 160 


Lys Ser Ala Ser Trp Ile Thr Arg Ile Arg Pro Glu Leu Val Lys Asn 
                165                 170                 175     


Gly Gln Phe His Ile Pro Ser Ile Thr Trp Glu His Thr Gly Arg Tyr 
            180                 185                 190         


Gly Cys Gln Tyr Tyr Ser Arg Ala Arg Trp Ser Glu Leu Ser Asp Pro 
        195                 200                 205             


Leu Val Leu Val Met Thr Gly Ala Tyr Pro Lys Pro Thr Leu Ser Ala 
    210                 215                 220                 


Gln Pro Ser Pro Val Val Thr Ser Gly Gly Arg Val Thr Leu Gln Cys 
225                 230                 235                 240 


Glu Ser Gln Val Ala Phe Gly Gly Phe Ile Leu Cys Lys Glu Gly Glu 
                245                 250                 255     


Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly Ser 
            260                 265                 270         


Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Asn Arg Arg Trp 
        275                 280                 285             


Ser His Arg Cys Tyr Gly Tyr Asp Leu Asn Ser Pro Tyr Val Trp Ser 
    290                 295                 300                 


Ser Pro Ser Asp Leu Leu Glu Leu Leu Val Pro Gly Val Ser Lys Lys 
305                 310                 315                 320 


Pro Ser Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp Lys 
                325                 330                 335     


<210>  27
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H-ficolin HIV SOSIP construct


<220>
<221>  CDS
<222>  (13)..(2271)

<400>  27
ggatccgccg cc atg gac ctc ctg tgg atc ttg ccc tcc ctg tgg ctt ctc       51
              Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu         
              1               5                   10                      

ctg ctt ggt ggc cct gcc tgc ctg aaa acc cag gag cac cct tca tgc         99
Leu Leu Gly Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys           
    15                  20                  25                            

cct gga ccc agg gaa ctc gaa gct agc aaa gtg gtc ctg ctg ccc tct        147
Pro Gly Pro Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser           
30                  35                  40                  45            

tgt ccc gga gca cca gga agt cct ggc gag aag gga gcc cca ggt cct        195
Cys Pro Gly Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro           
                50                  55                  60                

cag ggc cca cct gga cca cca ggc aag atg ggc ccc aag ggt gag cca        243
Gln Gly Pro Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro           
            65                  70                  75                    

ggc ccc aga gga ggt ggc agt ggt ggc gga tct ggc gga ggt tca gcc        291
Gly Pro Arg Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala           
        80                  85                  90                        

gag aat ctc tgg gtc act gtg tat tac ggc gtc cct gtc tgg aaa gag        339
Glu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu           
    95                  100                 105                           

gcc aaa act act ctg ttc tgt gct tcc gat gct aag gcc tac gaa aaa        387
Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys           
110                 115                 120                 125           

gag gtg cac aac gtc tgg gcc acc cat gct tgc gtg ccc aca gac cca        435
Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro           
                130                 135                 140               

aat ccc cag gaa gtg gtt ctg gag aac gtg aca gaa aat ttc aac atg        483
Asn Pro Gln Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met           
            145                 150                 155                   

tgg aag aac gac atg gtg gat cag atg cag gag gac gtc att agt atc        531
Trp Lys Asn Asp Met Val Asp Gln Met Gln Glu Asp Val Ile Ser Ile           
        160                 165                 170                       

tgg gat cag tca ctg aaa cca tgc gtg aag ctg acc ccc ctc tgc gtc        579
Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val           
    175                 180                 185                           

act ctg aat tgt acc aat gtg aac gtt aca tct aac agt act aat gtg        627
Thr Leu Asn Cys Thr Asn Val Asn Val Thr Ser Asn Ser Thr Asn Val           
190                 195                 200                 205           

aac agc tcc tct aca gat aat acc aca ctt ggc gag atc aaa aac tgt        675
Asn Ser Ser Ser Thr Asp Asn Thr Thr Leu Gly Glu Ile Lys Asn Cys           
                210                 215                 220               

tct ttc gac att act acc gag atc agg gat aaa act cgc aag gaa tac        723
Ser Phe Asp Ile Thr Thr Glu Ile Arg Asp Lys Thr Arg Lys Glu Tyr           
            225                 230                 235                   

gcc ctg ttt tat cgg ctg gac att gtt cct ttg gat aat agt tca aat        771
Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asp Asn Ser Ser Asn           
        240                 245                 250                       

cca aac agc tcc aac act tat aga ctc atc aat tgc aac acc tcc aca        819
Pro Asn Ser Ser Asn Thr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr           
    255                 260                 265                           

tgc act cag gct tgt cca aag gtg acc ttc gac cct att cca atc cac        867
Cys Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His           
270                 275                 280                 285           

tac tgc gct ccc gca ggc tat gca att ctg aaa tgt aac aat aag acc        915
Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr           
                290                 295                 300               

ttt aac ggt aaa ggt ccc tgc aac aat gtc agt acc gtc cag tgt aca        963
Phe Asn Gly Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr           
            305                 310                 315                   

cat ggt atc aag cct gtg gtt agt aca cag ttg ctc ctg aat gga tca       1011
His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser           
        320                 325                 330                       

ctg gcc gag gaa gag att gtg atc aga agc aaa aat ctt tca gat aac       1059
Leu Ala Glu Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Ser Asp Asn           
    335                 340                 345                           

gcc aag atc att atc gtg cag ctg aac aag tca gtg gag atc gtc tgc       1107
Ala Lys Ile Ile Ile Val Gln Leu Asn Lys Ser Val Glu Ile Val Cys           
350                 355                 360                 365           

act cgc ccc aac aat aac acc cgg aga agc att agg atc ggc cct ggt       1155
Thr Arg Pro Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly           
                370                 375                 380               

cag act ttc tac gcc acc gac att atc ggc gat att aga cag gcc tat       1203
Gln Thr Phe Tyr Ala Thr Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr           
            385                 390                 395                   

tgt aat atc agc ggt agg aac tgg tcc gaa gcc gtg aat cag gtt aag       1251
Cys Asn Ile Ser Gly Arg Asn Trp Ser Glu Ala Val Asn Gln Val Lys           
        400                 405                 410                       

aaa aag ctg aaa gaa cac ttc cca cat aag aac att tcc ttt cag tct       1299
Lys Lys Leu Lys Glu His Phe Pro His Lys Asn Ile Ser Phe Gln Ser           
    415                 420                 425                           

agt tca ggc ggt gac ctg gag atc aca act cac tct ttc aat tgc ggt       1347
Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly           
430                 435                 440                 445           

ggc gag ttc ttt tac tgt aac acc agc ggc ctc ttt aat gat aca att       1395
Gly Glu Phe Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Asp Thr Ile           
                450                 455                 460               

tcc aac gcc act atc atg ttg ccc tgc cgg atc aag cag att atc aat       1443
Ser Asn Ala Thr Ile Met Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn           
            465                 470                 475                   

atg tgg cag gag gtg ggc aag tgt atc tat gca ccc ccc atc aag ggt       1491
Met Trp Gln Glu Val Gly Lys Cys Ile Tyr Ala Pro Pro Ile Lys Gly           
        480                 485                 490                       

aac atc acc tgt aag agc gac att act ggc ctg ctc ctg ctt cgg gat       1539
Asn Ile Thr Cys Lys Ser Asp Ile Thr Gly Leu Leu Leu Leu Arg Asp           
    495                 500                 505                           

ggt ggc aat acc acc aat aac act gaa atc ttt aga cct ggc ggt gga       1587
Gly Gly Asn Thr Thr Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly           
510                 515                 520                 525           

gac atg cgc gat aac tgg cgg tcc gag ttg tac aaa tat aag gtt gtc       1635
Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val           
                530                 535                 540               

aaa atc gaa ccc ttg gga gtg gca cct act aga tgc aag agg cgc gtg       1683
Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg Val           
            545                 550                 555                   

gtt gga cgg cgc aga cgg agg cgc gca gtg gga atc ggc gct gtc ttc       1731
Val Gly Arg Arg Arg Arg Arg Arg Ala Val Gly Ile Gly Ala Val Phe           
        560                 565                 570                       

ctg ggc ttt ctg gga gca gct gga tca acc atg gga gca gcc agc atg       1779
Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met           
    575                 580                 585                           

acc ctc aca gtg cag gct agg aat ctt ctc tcc ggt att gtt cag cag       1827
Thr Leu Thr Val Gln Ala Arg Asn Leu Leu Ser Gly Ile Val Gln Gln           
590                 595                 600                 605           

cag tct aac ttg ctg cgc gca cct gag gcc cag cag cac ctg ctc aaa       1875
Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys           
                610                 615                 620               

ctc aca gtg tgg ggc atc aag cag ctt cag gct agg gtg ctt gca gtt       1923
Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val           
            625                 630                 635                   

gaa cgg tat ctg aga gac cag cag ctg ctc ggc att tgg ggt tgt agc       1971
Glu Arg Tyr Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser           
        640                 645                 650                       

ggc aag ctc atc tgc tgt acc aat gtg cca tgg aac agc tcc tgg tct       2019
Gly Lys Leu Ile Cys Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser           
    655                 660                 665                           

aat cgc aac ttg agt gag att tgg gac aat atg acc tgg ctg cag tgg       2067
Asn Arg Asn Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp           
670                 675                 680                 685           

gat aag gaa atc tct aac tac aca cag atc atc tac gga ctg ctg gaa       2115
Asp Lys Glu Ile Ser Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu           
                690                 695                 700               

gag agt cag aat cag cag gaa aag aac gag cag gac ctt ctt gcc ttg       2163
Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu           
            705                 710                 715                   

gat gga ggc ggt agc atg cac gcc aag ttc gtg gct gca tgg acc ctg       2211
Asp Gly Gly Gly Ser Met His Ala Lys Phe Val Ala Ala Trp Thr Leu           
        720                 725                 730                       

aaa gca gcc gct atg cat ggt acc gca ggt agc gaa gac tat aaa gac       2259
Lys Ala Ala Ala Met His Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp           
    735                 740                 745                           

gat gat gac aag tgatgactcg ag                                         2283
Asp Asp Asp Lys                                                           
750                                                                       


<210>  28
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Asp Leu Leu Trp Ile Leu Pro Ser Leu Trp Leu Leu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ala Cys Leu Lys Thr Gln Glu His Pro Ser Cys Pro Gly Pro 
            20                  25                  30          


Arg Glu Leu Glu Ala Ser Lys Val Val Leu Leu Pro Ser Cys Pro Gly 
        35                  40                  45              


Ala Pro Gly Ser Pro Gly Glu Lys Gly Ala Pro Gly Pro Gln Gly Pro 
    50                  55                  60                  


Pro Gly Pro Pro Gly Lys Met Gly Pro Lys Gly Glu Pro Gly Pro Arg 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Ala Glu Asn Leu 
                85                  90                  95      


Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr 
            100                 105                 110         


Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Glu Lys Glu Val His 
        115                 120                 125             


Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln 
    130                 135                 140                 


Glu Val Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn 
145                 150                 155                 160 


Asp Met Val Asp Gln Met Gln Glu Asp Val Ile Ser Ile Trp Asp Gln 
                165                 170                 175     


Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn 
            180                 185                 190         


Cys Thr Asn Val Asn Val Thr Ser Asn Ser Thr Asn Val Asn Ser Ser 
        195                 200                 205             


Ser Thr Asp Asn Thr Thr Leu Gly Glu Ile Lys Asn Cys Ser Phe Asp 
    210                 215                 220                 


Ile Thr Thr Glu Ile Arg Asp Lys Thr Arg Lys Glu Tyr Ala Leu Phe 
225                 230                 235                 240 


Tyr Arg Leu Asp Ile Val Pro Leu Asp Asn Ser Ser Asn Pro Asn Ser 
                245                 250                 255     


Ser Asn Thr Tyr Arg Leu Ile Asn Cys Asn Thr Ser Thr Cys Thr Gln 
            260                 265                 270         


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        275                 280                 285             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    290                 295                 300                 


Lys Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
305                 310                 315                 320 


Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                325                 330                 335     


Glu Glu Ile Val Ile Arg Ser Lys Asn Leu Ser Asp Asn Ala Lys Ile 
            340                 345                 350         


Ile Ile Val Gln Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro 
        355                 360                 365             


Asn Asn Asn Thr Arg Arg Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
    370                 375                 380                 


Tyr Ala Thr Asp Ile Ile Gly Asp Ile Arg Gln Ala Tyr Cys Asn Ile 
385                 390                 395                 400 


Ser Gly Arg Asn Trp Ser Glu Ala Val Asn Gln Val Lys Lys Lys Leu 
                405                 410                 415     


Lys Glu His Phe Pro His Lys Asn Ile Ser Phe Gln Ser Ser Ser Gly 
            420                 425                 430         


Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe 
        435                 440                 445             


Phe Tyr Cys Asn Thr Ser Gly Leu Phe Asn Asp Thr Ile Ser Asn Ala 
    450                 455                 460                 


Thr Ile Met Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
465                 470                 475                 480 


Glu Val Gly Lys Cys Ile Tyr Ala Pro Pro Ile Lys Gly Asn Ile Thr 
                485                 490                 495     


Cys Lys Ser Asp Ile Thr Gly Leu Leu Leu Leu Arg Asp Gly Gly Asn 
            500                 505                 510         


Thr Thr Asn Asn Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg 
        515                 520                 525             


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
    530                 535                 540                 


Pro Leu Gly Val Ala Pro Thr Arg Cys Lys Arg Arg Val Val Gly Arg 
545                 550                 555                 560 


Arg Arg Arg Arg Arg Ala Val Gly Ile Gly Ala Val Phe Leu Gly Phe 
                565                 570                 575     


Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr 
            580                 585                 590         


Val Gln Ala Arg Asn Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn 
        595                 600                 605             


Leu Leu Arg Ala Pro Glu Ala Gln Gln His Leu Leu Lys Leu Thr Val 
    610                 615                 620                 


Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr 
625                 630                 635                 640 


Leu Arg Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu 
                645                 650                 655     


Ile Cys Cys Thr Asn Val Pro Trp Asn Ser Ser Trp Ser Asn Arg Asn 
            660                 665                 670         


Leu Ser Glu Ile Trp Asp Asn Met Thr Trp Leu Gln Trp Asp Lys Glu 
        675                 680                 685             


Ile Ser Asn Tyr Thr Gln Ile Ile Tyr Gly Leu Leu Glu Glu Ser Gln 
    690                 695                 700                 


Asn Gln Gln Glu Lys Asn Glu Gln Asp Leu Leu Ala Leu Asp Gly Gly 
705                 710                 715                 720 


Gly Ser Met His Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala 
                725                 730                 735     


Ala Met His Gly Thr Ala Gly Ser Glu Asp Tyr Lys Asp Asp Asp Asp 
            740                 745                 750         


Lys 
    


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  29

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  30

Gly Gly Gly Ser 
1               


