                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
       Parhiz, Hamideh
       Weissman, Drew
       Epstein, Jonathan
       Tombacz, Istvan
       Runik, Joel
       Aghajanian, Haig
 
<120>  In vivo targeting of Fibrosis by anti-CD5-targeted FAP-CAR T 
       mRNA-LNP

<130>  046483-6213-00WO

<150>  US 63/090,998
<151>  2020-10-13

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, murine-FAPCAR

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Ala 
    50                  55                  60                  


Asp Lys Arg Leu Glu Leu Val Ala Thr Thr Asn Asn Asn Gly Gly Val 
65                  70                  75                  80  


Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Gln Ser Glu 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Tyr Gly Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Ile Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Val Leu Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Val Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr Gly Thr 
        275                 280                 285             


Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser Val Lys 
    290                 295                 300                 


Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr Leu Ile 
                325                 330                 335     


Cys Tyr His Arg Ser Arg Asn Ser Arg Arg Asn Arg Leu Leu Gln Val 
            340                 345                 350         


Thr Thr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg 
    370                 375                 380                 


Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln 
            420                 425                 430         


Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
                485                 490                 495     


<210>  2
<211>  1491
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, murine-FAPCAR

<400>  2
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgcccgc       60

cccggctccc aggtgcagct gaaggagtcc ggcggcggcc tggtgcagcc cggcggctcc      120

ctgaagctgt cctgcgccgc ctccggcttc accttctcct cctacggcat gtcctgggtg      180

cgccagaccg ccgacaagcg cctggagctg gtggccacca ccaacaacaa cggcggcgtg      240

acctactacc ccgactccgt gaagggccgc ttcaccatct cccgcgacaa cgccaagaac      300

accctgtacc tgcagatgtc ctccctgcag tccgaggaca ccgccatgta ctactgcgcc      360

cgctacggct actacgccat ggactactgg ggccagggca tctccgtgac cgtgtcctcc      420

ggcggcggcg gctccggcgg cggcggctcc tccggcggcg gctccgacgt gctgatgacc      480

cagacccccc tgtccctgcc cgtgtccctg ggcgaccagg cctccatctc ctgccgctcc      540

tcccagtcca tcgtgcactc caacggcaac acctacctgg agtggtacct gcagaagccc      600

ggccagtccc ccaagctgct gatctacaag gtgtccaacc gcttctccgg cgtgcccgac      660

cgcttctccg gctccggctc cggcaccgac ttcaccgtga agatctcccg cgtggaggcc      720

gaggacctgg gcgtgtacta ctgcttccag ggctcccacg tgccctacac cttcggcggc      780

ggcaccaagc tggagatcaa ggccgccgcc accaccacca agcccgtgct gcgcaccccc      840

tcccccgtgc accccaccgg cacctcccag ccccagcgcc ccgaggactg ccgcccccgc      900

ggctccgtga agggcaccgg cctggacttc gcctgcgaca tctacatctg ggcccccctg      960

gccggcatct gcgtggccct gctgctgtcc ctgatcatca ccctgatctg ctaccaccgc     1020

tcccgcaact cccgccgcaa ccgcctgctg caggtgacca ccatgaacat gaccccccgc     1080

cgccccggcc tgacccgcaa gccctaccag ccctacgccc ccgcccgcga cttcgccgcc     1140

taccgccccc gcgccaagtt ctcccgctcc gccgagaccg ccgccaacct gcaggacccc     1200

aaccagctgt acaacgagct gaacctgggc cgccgcgagg agtacgacgt gctggagaag     1260

aagcgcgccc gcgaccccga gatgggcggc aagcagcagc gccgccgcaa cccccaggag     1320

ggcgtgtaca acgccctgca gaaggacaag atggccgagg cctactccga gatcggcacc     1380

aagggcgagc gccgccgcgg caagggccac gacggcctgt accagggcct gtccaccgcc     1440

accaaggaca cctacgacgc cctgcacatg cagaccctgg ccccccgcta a              1491


<210>  3
<211>  1491
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized, murine-FAPCAR

<400>  3
auggcccugc ccgugaccgc ccugcugcug ccccuggccc ugcugcugca cgccgcccgc       60

cccggcuccc aggugcagcu gaaggagucc ggcggcggcc uggugcagcc cggcggcucc      120

cugaagcugu ccugcgccgc cuccggcuuc accuucuccu ccuacggcau guccugggug      180

cgccagaccg ccgacaagcg ccuggagcug guggccacca ccaacaacaa cggcggcgug      240

accuacuacc ccgacuccgu gaagggccgc uucaccaucu cccgcgacaa cgccaagaac      300

acccuguacc ugcagauguc cucccugcag uccgaggaca ccgccaugua cuacugcgcc      360

cgcuacggcu acuacgccau ggacuacugg ggccagggca ucuccgugac cguguccucc      420

ggcggcggcg gcuccggcgg cggcggcucc uccggcggcg gcuccgacgu gcugaugacc      480

cagacccccc ugucccugcc cgugucccug ggcgaccagg ccuccaucuc cugccgcucc      540

ucccagucca ucgugcacuc caacggcaac accuaccugg agugguaccu gcagaagccc      600

ggccaguccc ccaagcugcu gaucuacaag guguccaacc gcuucuccgg cgugcccgac      660

cgcuucuccg gcuccggcuc cggcaccgac uucaccguga agaucucccg cguggaggcc      720

gaggaccugg gcguguacua cugcuuccag ggcucccacg ugcccuacac cuucggcggc      780

ggcaccaagc uggagaucaa ggccgccgcc accaccacca agcccgugcu gcgcaccccc      840

ucccccgugc accccaccgg caccucccag ccccagcgcc ccgaggacug ccgcccccgc      900

ggcuccguga agggcaccgg ccuggacuuc gccugcgaca ucuacaucug ggccccccug      960

gccggcaucu gcguggcccu gcugcugucc cugaucauca cccugaucug cuaccaccgc     1020

ucccgcaacu cccgccgcaa ccgccugcug caggugacca ccaugaacau gaccccccgc     1080

cgccccggcc ugacccgcaa gcccuaccag cccuacgccc ccgcccgcga cuucgccgcc     1140

uaccgccccc gcgccaaguu cucccgcucc gccgagaccg ccgccaaccu gcaggacccc     1200

aaccagcugu acaacgagcu gaaccugggc cgccgcgagg aguacgacgu gcuggagaag     1260

aagcgcgccc gcgaccccga gaugggcggc aagcagcagc gccgccgcaa cccccaggag     1320

ggcguguaca acgcccugca gaaggacaag auggccgagg ccuacuccga gaucggcacc     1380

aagggcgagc gccgccgcgg caagggccac gacggccugu accagggccu guccaccgcc     1440

accaaggaca ccuacgacgc ccugcacaug cagacccugg ccccccgcua a              1491


<210>  4
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Mu-FAPCAR-Mu-CD28Z-P2A-RISR-RIAD

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser Trp Val Arg Gln Thr Ala 
    50                  55                  60                  


Asp Lys Arg Leu Glu Leu Val Ala Thr Thr Asn Asn Asn Gly Gly Val 
65                  70                  75                  80  


Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                85                  90                  95      


Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Gln Ser Glu 
            100                 105                 110         


Asp Thr Ala Met Tyr Tyr Cys Ala Arg Tyr Gly Tyr Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Ile Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Asp Val Leu Met Thr 
145                 150                 155                 160 


Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        195                 200                 205             


Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Val Lys Ile Ser Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Tyr 
                245                 250                 255     


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Lys Pro Val Leu Arg Thr Pro Ser Pro Val His Pro Thr Gly Thr 
        275                 280                 285             


Ser Gln Pro Gln Arg Pro Glu Asp Cys Arg Pro Arg Gly Ser Val Lys 
    290                 295                 300                 


Gly Thr Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Ile Cys Val Ala Leu Leu Leu Ser Leu Ile Ile Thr Leu Ile 
                325                 330                 335     


Cys Tyr His Arg Ser Arg Asn Ser Arg Arg Asn Arg Leu Leu Gln Val 
            340                 345                 350         


Thr Thr Met Asn Met Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro 
        355                 360                 365             


Tyr Gln Pro Tyr Ala Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro Arg 
    370                 375                 380                 


Ala Lys Phe Ser Arg Ser Ala Glu Thr Ala Ala Asn Leu Gln Asp Pro 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Glu Lys Lys Arg Ala Arg Asp Pro Glu Met Gly Gly Lys Gln 
            420                 425                 430         


Gln Arg Arg Arg Asn Pro Gln Glu Gly Val Tyr Asn Ala Leu Gln Lys 
        435                 440                 445             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Thr Lys Gly Glu Arg 
    450                 455                 460                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
465                 470                 475                 480 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Thr Leu Ala Pro Arg 
                485                 490                 495     


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            500                 505                 510         


Glu Glu Asn Pro Gly Pro Glu Ser Lys Arg Arg Gln Glu Glu Ala Glu 
        515                 520                 525             


Gln Arg Lys Leu Glu Gln Tyr Ala Asn Gln Leu Ala Asp Gln Ile Ile 
    530                 535                 540                 


Lys Glu Ala Thr Glu 
545                 


<210>  5
<211>  1650
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Mu-FAPCAR-Mu-CD28Z-P2A-RISR-RIAD

<400>  5
atggccctgc ccgtgaccgc cctgctgctg cccctggccc tgctgctgca cgccgcccgc       60

cccggctccc aggtgcagct gaaggagtcc ggcggcggcc tggtgcagcc cggcggctcc      120

ctgaagctgt cctgcgccgc ctccggcttc accttctcct cctacggcat gtcctgggtg      180

cgccagaccg ccgacaagcg cctggagctg gtggccacca ccaacaacaa cggcggcgtg      240

acctactacc ccgactccgt gaagggccgc ttcaccatct cccgcgacaa cgccaagaac      300

accctgtacc tgcagatgtc ctccctgcag tccgaggaca ccgccatgta ctactgcgcc      360

cgctacggct actacgccat ggactactgg ggccagggca tctccgtgac cgtgtcctcc      420

ggcggcggcg gctccggcgg cggcggctcc tccggcggcg gctccgacgt gctgatgacc      480

cagacccccc tgtccctgcc cgtgtccctg ggcgaccagg cctccatctc ctgccgctcc      540

tcccagtcca tcgtgcactc caacggcaac acctacctgg agtggtacct gcagaagccc      600

ggccagtccc ccaagctgct gatctacaag gtgtccaacc gcttctccgg cgtgcccgac      660

cgcttctccg gctccggctc cggcaccgac ttcaccgtga agatctcccg cgtggaggcc      720

gaggacctgg gcgtgtacta ctgcttccag ggctcccacg tgccctacac cttcggcggc      780

ggcaccaagc tggagatcaa ggccgccgcc accaccacca agcccgtgct gcgcaccccc      840

tcccccgtgc accccaccgg cacctcccag ccccagcgcc ccgaggactg ccgcccccgc      900

ggctccgtga agggcaccgg cctggacttc gcctgcgaca tctacatctg ggcccccctg      960

gccggcatct gcgtggccct gctgctgtcc ctgatcatca ccctgatctg ctaccaccgc     1020

tcccgcaact cccgccgcaa ccgcctgctg caggtgacca ccatgaacat gaccccccgc     1080

cgccccggcc tgacccgcaa gccctaccag ccctacgccc ccgcccgcga cttcgccgcc     1140

taccgccccc gcgccaagtt ctcccgctcc gccgagaccg ccgccaacct gcaggacccc     1200

aaccagctgt acaacgagct gaacctgggc cgccgcgagg agtacgacgt gctggagaag     1260

aagcgcgccc gcgaccccga gatgggcggc aagcagcagc gccgccgcaa cccccaggag     1320

ggcgtgtaca acgccctgca gaaggacaag atggccgagg cctactccga gatcggcacc     1380

aagggcgagc gccgccgcgg caagggccac gacggcctgt accagggcct gtccaccgcc     1440

accaaggaca cctacgacgc cctgcacatg cagaccctgg ccccccgcgg ctccggcgcc     1500

accaacttct ccctgctgaa gcaggccggc gacgtggagg agaaccccgg ccccgagtcc     1560

aagcgccgcc aggaggaggc cgagcagcgc aagctggagc agtacgccaa ccagctggcc     1620

gaccagatca tcaaggaggc caccgagtaa                                      1650


<210>  6
<211>  1650
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized, Mu-FAPCAR-Mu-CD28Z-P2A-RISR-RIAD

<400>  6
auggcccugc ccgugaccgc ccugcugcug ccccuggccc ugcugcugca cgccgcccgc       60

cccggcuccc aggugcagcu gaaggagucc ggcggcggcc uggugcagcc cggcggcucc      120

cugaagcugu ccugcgccgc cuccggcuuc accuucuccu ccuacggcau guccugggug      180

cgccagaccg ccgacaagcg ccuggagcug guggccacca ccaacaacaa cggcggcgug      240

accuacuacc ccgacuccgu gaagggccgc uucaccaucu cccgcgacaa cgccaagaac      300

acccuguacc ugcagauguc cucccugcag uccgaggaca ccgccaugua cuacugcgcc      360

cgcuacggcu acuacgccau ggacuacugg ggccagggca ucuccgugac cguguccucc      420

ggcggcggcg gcuccggcgg cggcggcucc uccggcggcg gcuccgacgu gcugaugacc      480

cagacccccc ugucccugcc cgugucccug ggcgaccagg ccuccaucuc cugccgcucc      540

ucccagucca ucgugcacuc caacggcaac accuaccugg agugguaccu gcagaagccc      600

ggccaguccc ccaagcugcu gaucuacaag guguccaacc gcuucuccgg cgugcccgac      660

cgcuucuccg gcuccggcuc cggcaccgac uucaccguga agaucucccg cguggaggcc      720

gaggaccugg gcguguacua cugcuuccag ggcucccacg ugcccuacac cuucggcggc      780

ggcaccaagc uggagaucaa ggccgccgcc accaccacca agcccgugcu gcgcaccccc      840

ucccccgugc accccaccgg caccucccag ccccagcgcc ccgaggacug ccgcccccgc      900

ggcuccguga agggcaccgg ccuggacuuc gccugcgaca ucuacaucug ggccccccug      960

gccggcaucu gcguggcccu gcugcugucc cugaucauca cccugaucug cuaccaccgc     1020

ucccgcaacu cccgccgcaa ccgccugcug caggugacca ccaugaacau gaccccccgc     1080

cgccccggcc ugacccgcaa gcccuaccag cccuacgccc ccgcccgcga cuucgccgcc     1140

uaccgccccc gcgccaaguu cucccgcucc gccgagaccg ccgccaaccu gcaggacccc     1200

aaccagcugu acaacgagcu gaaccugggc cgccgcgagg aguacgacgu gcuggagaag     1260

aagcgcgccc gcgaccccga gaugggcggc aagcagcagc gccgccgcaa cccccaggag     1320

ggcguguaca acgcccugca gaaggacaag auggccgagg ccuacuccga gaucggcacc     1380

aagggcgagc gccgccgcgg caagggccac gacggccugu accagggccu guccaccgcc     1440

accaaggaca ccuacgacgc ccugcacaug cagacccugg ccccccgcgg cuccggcgcc     1500

accaacuucu cccugcugaa gcaggccggc gacguggagg agaaccccgg ccccgagucc     1560

aagcgccgcc aggaggaggc cgagcagcgc aagcuggagc aguacgccaa ccagcuggcc     1620

gaccagauca ucaaggaggc caccgaguaa                                      1650


<210>  7
<211>  494
<212>  PRT
<213>  Mus musculus

<400>  7

Met Asp Ser His Glu Val Leu Leu Ala Ala Thr Tyr Leu Leu Gly Thr 
1               5                   10                  15      


Leu Ala Ala Phe Cys Leu Gly Gln Ser Gly Arg Gly Gly Leu Asp Ile 
            20                  25                  30          


Gln Val Met Leu Ser Gly Ser Asn Ser Lys Cys Gln Gly Gln Val Glu 
        35                  40                  45              


Ile Gln Met Glu Asn Lys Trp Lys Thr Val Cys Ser Ser Ser Trp Arg 
    50                  55                  60                  


Leu Ser Gln Asp His Ser Lys Asn Ala Gln Gln Ala Ser Ala Val Cys 
65                  70                  75                  80  


Lys Gln Leu Arg Cys Gly Asp Pro Leu Ala Leu Gly Pro Phe Pro Ser 
                85                  90                  95      


Leu Asn Arg Pro Gln Asn Gln Val Phe Cys Gln Gly Ser Pro Trp Ser 
            100                 105                 110         


Ile Ser Asn Cys Asn Asn Thr Ser Ser Gln Asp Gln Cys Leu Pro Leu 
        115                 120                 125             


Ser Leu Ile Cys Leu Glu Pro Gln Arg Thr Thr Pro Pro Pro Thr Thr 
    130                 135                 140                 


Thr Pro Pro Thr Thr Val Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Pro Gly His Glu Gly Leu Arg Cys Thr Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Asn Gly Ser Trp Gly Gly Thr Ile Leu Tyr Lys Ala Lys Asp Arg 
            180                 185                 190         


Pro Leu Gly Leu Gly Asn Leu Ile Cys Lys Ser Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Thr His Leu Ser Gly Thr Glu Ala Ala Gly Thr Pro Ala Pro 
    210                 215                 220                 


Ala Glu Leu Arg Asp Pro Arg Pro Leu Pro Ile Arg Trp Glu Ala Pro 
225                 230                 235                 240 


Asn Gly Ser Cys Val Ser Leu Gln Gln Cys Phe Gln Lys Thr Thr Ala 
                245                 250                 255     


Gln Glu Gly Gly Gln Ala Leu Thr Val Ile Cys Ser Asp Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Val Cys Glu Gly Ile 
        275                 280                 285             


Ala Glu Val Arg Gln Arg Ser Gln Trp Glu Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ala Ala Arg Gly Arg Gly Arg Trp Glu Glu Leu Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Asp Leu Ile Ser Phe His Thr Val Asp Ala Asp Lys Thr Ser 
                325                 330                 335     


Pro Gly Phe Leu Cys Ala Gln Glu Lys Leu Ser Gln Cys Tyr His Leu 
            340                 345                 350         


Gln Lys Lys Lys His Cys Asn Lys Arg Val Phe Val Thr Cys Gln Asp 
        355                 360                 365             


Pro Asn Pro Ala Gly Leu Ala Pro Gly Thr Val Ala Ser Ile Ile Leu 
    370                 375                 380                 


Thr Leu Val Leu Leu Val Val Leu Leu Ala Met Cys Gly Pro Leu Val 
385                 390                 395                 400 


Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln Trp 
                405                 410                 415     


Ile Gly Pro Thr Gly Val Asn Gln Asn Met Ser Phe His Arg Ser His 
            420                 425                 430         


Thr Ala Thr Val Arg Ser Gln Val Glu Asn Pro Thr Ala Ser His Val 
        435                 440                 445             


Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala Tyr 
    450                 455                 460                 


Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Thr Gln Pro Asp Asn 
465                 470                 475                 480 


Ser Ser Asp Ser Asp Tyr Asp Leu Gln Val Ala Gln Arg Leu 
                485                 490                 


<210>  8
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Cys Leu Gly Arg Leu Ser Trp Tyr Asp Pro Asp 
            20                  25                  30          


Phe Gln Ala Arg Leu Thr Arg Ser Asn Ser Lys Cys Gln Gly Gln Leu 
        35                  40                  45              


Glu Val Tyr Leu Lys Asp Gly Trp His Met Val Cys Ser Gln Ser Trp 
    50                  55                  60                  


Gly Arg Ser Ser Lys Gln Trp Glu Asp Pro Ser Gln Ala Ser Lys Val 
65                  70                  75                  80  


Cys Gln Arg Leu Asn Cys Gly Val Pro Leu Ser Leu Gly Pro Phe Leu 
                85                  90                  95      


Val Thr Tyr Thr Pro Gln Ser Ser Ile Ile Cys Tyr Gly Gln Leu Gly 
            100                 105                 110         


Ser Phe Ser Asn Cys Ser His Ser Arg Asn Asp Met Cys His Ser Leu 
        115                 120                 125             


Gly Leu Thr Cys Leu Glu Pro Gln Lys Thr Thr Pro Pro Thr Thr Arg 
    130                 135                 140                 


Pro Pro Pro Thr Thr Thr Pro Glu Pro Thr Ala Pro Pro Arg Leu Gln 
145                 150                 155                 160 


Leu Val Ala Gln Ser Gly Gly Gln His Cys Ala Gly Val Val Glu Phe 
                165                 170                 175     


Tyr Ser Gly Ser Leu Gly Gly Thr Ile Ser Tyr Glu Ala Gln Asp Lys 
            180                 185                 190         


Thr Gln Asp Leu Glu Asn Phe Leu Cys Asn Asn Leu Gln Cys Gly Ser 
        195                 200                 205             


Phe Leu Lys His Leu Pro Glu Thr Glu Ala Gly Arg Ala Gln Asp Pro 
    210                 215                 220                 


Gly Glu Pro Arg Glu His Gln Pro Leu Pro Ile Gln Trp Lys Ile Gln 
225                 230                 235                 240 


Asn Ser Ser Cys Thr Ser Leu Glu His Cys Phe Arg Lys Ile Lys Pro 
                245                 250                 255     


Gln Lys Ser Gly Arg Val Leu Ala Leu Leu Cys Ser Gly Phe Gln Pro 
            260                 265                 270         


Lys Val Gln Ser Arg Leu Val Gly Gly Ser Ser Ile Cys Glu Gly Thr 
        275                 280                 285             


Val Glu Val Arg Gln Gly Ala Gln Trp Ala Ala Leu Cys Asp Ser Ser 
    290                 295                 300                 


Ser Ala Arg Ser Ser Leu Arg Trp Glu Glu Val Cys Arg Glu Gln Gln 
305                 310                 315                 320 


Cys Gly Ser Val Asn Ser Tyr Arg Val Leu Asp Ala Gly Asp Pro Thr 
                325                 330                 335     


Ser Arg Gly Leu Phe Cys Pro His Gln Lys Leu Ser Gln Cys His Glu 
            340                 345                 350         


Leu Trp Glu Arg Asn Ser Tyr Cys Lys Lys Val Phe Val Thr Cys Gln 
        355                 360                 365             


Asp Pro Asn Pro Ala Gly Leu Ala Ala Gly Thr Val Ala Ser Ile Ile 
    370                 375                 380                 


Leu Ala Leu Val Leu Leu Val Val Leu Leu Val Val Cys Gly Pro Leu 
385                 390                 395                 400 


Ala Tyr Lys Lys Leu Val Lys Lys Phe Arg Gln Lys Lys Gln Arg Gln 
                405                 410                 415     


Trp Ile Gly Pro Thr Gly Met Asn Gln Asn Met Ser Phe His Arg Asn 
            420                 425                 430         


His Thr Ala Thr Val Arg Ser His Ala Glu Asn Pro Thr Ala Ser His 
        435                 440                 445             


Val Asp Asn Glu Tyr Ser Gln Pro Pro Arg Asn Ser His Leu Ser Ala 
    450                 455                 460                 


Tyr Pro Ala Leu Glu Gly Ala Leu His Arg Ser Ser Met Gln Pro Asp 
465                 470                 475                 480 


Asn Ser Ser Asp Ser Asp Tyr Asp Leu His Gly Ala Gln Arg Leu 
                485                 490                 495 


<210>  9
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  10
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Tyr 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


