                               SEQUENCE LISTING

<110> THE CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> NOTCH4 ANTIBODIES AND USES THEREOF

<130> 701039-190050WOPT

<140> PCT/US2021/055181
<141> 2021-10-15

<150> 63/181,018
<151> 2021-04-28

<150> 63/171,904
<151> 2021-04-07

<150> 63/092,872
<151> 2020-10-16

<160> 57    

<170> PatentIn version 3.5

<210> 1
<211> 5912
<212> DNA
<213> Homo sapiens

<400> 1
atgcagcccc cttcactgct gctgctgctg ctgctgctgc tgctgctatg tgtctcagtg       60

gtcagaccca gagggctgct gtgtgggagt ttcccagaac cctgtgccaa tggaggcacc      120

tgcctgagcc tgtctctggg acaagggacc tgccagtgtg cccctggctt cctgggtgag      180

acgtgccagt ttcctgaccc ctgccagaac gcccagctct gccaaaatgg aggcagctgc      240

caagccctgc ttcccgctcc cctagggctc cccagctctc cctctccatt gacacccagc      300

ttcttgtgca cttgcctccc tggcttcact ggtgagagat gccaggccaa gcttgaagac      360

ccttgtcctc cctccttctg ttccaaaagg ggccgctgcc acatccaggc ctcgggccgc      420

ccacagtgct cctgcatgcc tggatggaca ggtgagcagt gccagcttcg ggacttctgt      480

tcagccaacc catgtgttaa tggaggggtg tgtctggcca cataccccca gatccagtgc      540

cactgcccac cgggcttcga gggccatgcc tgtgaacgtg atgtcaacga gtgcttccag      600

gacccaggac cctgccccaa aggcacctcc tgccataaca ccctgggctc cttccagtgc      660

ctctgccctg tggggcagga gggtccacgt tgtgagctgc gggcaggacc ctgccctcct      720

aggggctgtt cgaatggggg cacctgccag ctgatgccag agaaagactc cacctttcac      780

ctctgcctct gtcccccagg tttcataggc ccagactgtg aggtgaatcc agacaactgt      840

gtcagccacc agtgtcagaa tgggggcact tgccaggatg ggctggacac ctacacctgc      900

ctctgcccag aaacctggac aggctgggac tgctccgaag atgtggatga gtgtgagacc      960

cagggtcccc ctcactgcag aaacgggggc acctgccaga actctgctgg tagctttcac     1020

tgcgtgtgtg tgagtggctg gggcggcaca agctgtgagg agaacctgga tgactgtatt     1080

gctgccacct gtgccccggg atccacctgc attgaccggg tgggctcttt ctcctgcctc     1140

tgcccacctg gacgcacagg actcctgtgc cacttggaag acatgtgtct gagccagccg     1200

tgccatgggg atgcccaatg cagcaccaac cccctcacag gctccacact ctgcctgtgt     1260

cagcctggct attcggggcc cacctgccac caggacctgg acgagtgtct gatggcccag     1320

caaggcccaa gtccctgtga acatggcggt tcctgcctca acactcctgg ctccttcaac     1380

tgcctctgtc cacctggcta cacaggctcc cgttgtgagg ctgatcacaa tgagtgcctc     1440

tcccagccct gccacccagg aagcacctgt ctggacctac ttgccacctt ccactgcctc     1500

tgcccgccag gcttagaagg gcagctctgt gaggtggaga ccaacgagtg tgcctcagct     1560

ccctgcctga accacgcgga ttgccatgac ctgctcaacg gcttccagtg catctgcctg     1620

cctggattct ccggcacccg atgtgaggag gatatcgatg agtgcagaag ctctccctgt     1680

gccaatggtg ggcagtgcca ggaccagcct ggagccttcc actgcaagtg tctcccaggc     1740

tttgaagggc cacgctgtca aacagaggtg gatgagtgcc tgagtgaccc atgtcccgtt     1800

ggagccagct gccttgatct tccaggagcc ttcttttgcc tctgcccctc tggtttcaca     1860

ggccagctct gtgaggttcc cctgtgtgct cccaacctgt gccagcccaa gcagatatgt     1920

aaggaccaga aagacaaggc caactgcctc tgtcctgatg gaagccctgg ctgtgcccca     1980

cctgaggaca actgcacctg ccaccacggg cactgccaga gatcctcatg tgtgtgtgac     2040

gtgggttgga cggggccaga gtgtgaggca gagctagggg gctgcatctc tgcaccctgt     2100

gcccatgggg ggacctgcta cccccagccc tctggctaca actgcacctg ccctacaggc     2160

tacacaggac ccacctgtag tgaggagatg acagcttgtc actcagggcc atgtctcaat     2220

ggcggctcct gcaaccctag ccctggaggc tactactgca cctgccctcc aagccacaca     2280

gggccccagt gccaaaccag cactgactac tgtgtgtctg ccccgtgctt caatgggggt     2340

acctgtgtga acaggcctgg caccttctcc tgcctctgtg ccatgggctt ccagggcccg     2400

cgctgtgagg gaaagctccg ccccagctgt gcagacagcc cctgtaggaa tagggcaacc     2460

tgccaggaca gccctcaggg tccccgctgc ctctgcccca ctggctacac cggaggcagc     2520

tgccagactc tgatggactt atgtgcccag aagccctgcc cacgcaattc ccactgcctc     2580

cagactgggc cctccttcca ctgcttgtgc ctccagggat ggaccgggcc tctctgcaac     2640

cttccactgt cctcctgcca gaaggctgca ctgagccaag gcatagacgt ctcttccctt     2700

tgccacaatg gaggcctctg tgtcgacagc ggcccctcct atttctgcca ctgcccccct     2760

ggattccaag gcagcctgtg ccaggatcac gtgaacccat gtgagtccag gccttgccag     2820

aacggggcca cctgcatggc ccagcccagt gggtatctct gccagtgtgc cccaggctac     2880

gatggacaga actgctcaaa ggaactcgat gcttgtcagt cccaaccctg tcacaaccat     2940

ggaacctgta ctcccaaacc tggaggattc cactgtgcct gccctccagg ctttgtgggg     3000

ctacgctgtg agggagacgt ggacgagtgt ctggaccagc cctgccaccc cacaggcact     3060

gcagcctgcc actctctggc caatgccttc tactgccagt gtctgcctgg acacacaggc     3120

cagtggtgtg aggtggagat agacccctgc cacagccaac cctgctttca tggagggacc     3180

tgtgaggcca cagcaggatc acccctgggt ttcatctgcc actgccccaa gggttttgaa     3240

ggccccacct gcagccacag ggccccttcc tgcggcttcc atcactgcca ccacggaggc     3300

ctgtgtctgc cctcccctaa gccaggcttc ccaccacgct gtgcctgcct cagtggctat     3360

gggggtcctg actgcctgac cccaccagct cctaaaggct gtggccctcc ctccccatgc     3420

ctatacaatg gcagctgctc agagaccacg ggcttggggg gcccaggctt tcgatgctcc     3480

tgccctcaca gctctccagg gccccggtgt cagaaacccg gagccaaggg gtgtgagggc     3540

agaagtggag atggggcctg cgatgctggc tgcagtggcc cgggaggaaa ctgggatgga     3600

ggggactgct ctctgggagt cccagacccc tggaagggct gcccctccca ctctcggtgc     3660

tggcttctct tccgggacgg gcagtgccac ccacagtgtg actctgaaga gtgtctgttt     3720

gatggctacg actgtgagac ccctccagcc tgcactccag cctatgacca gtactgccat     3780

gatcacttcc acaacgggca ctgtgagaaa ggctgcaaca ctgcagagtg tggctgggat     3840

ggaggtgact gcaggcctga agatggggac ccagagtggg ggccctccct ggccctgctg     3900

gtggtactga gccccccagc cctagaccag cagctgtttg ccctggcccg ggtgctgtcc     3960

ctgactctga gggtaggact ctgggtaagg aaggatcgtg atggcaggga catggtgtac     4020

ccctatcctg gggcccgggc tgaagaaaag ctaggaggaa ctcgggaccc cacctatcag     4080

gagagagcag cccctcaaac gcagcccctg ggcaaggaga ccgactccct cagtgctggg     4140

tttgtggtgg tcatgggtgt ggatttgtcc cgctgtggcc ctgaccaccc ggcatcccgc     4200

tgtccctggg accctgggct tctactccgc ttccttgctg cgatggctgc agtgggagcc     4260

ctggagcccc tgctgcctgg accactgctg gctgtccacc ctcatgcagg gaccgcaccc     4320

cctgccaacc agcttccctg gcctgtgctg tgctccccag tggccggggt gattctcctg     4380

gccctagggg ctcttctcgt cctccagctc atccggcgtc gacgccgaga gcatggagct     4440

ctctggctgc cccctggttt cactcgacgg cctcggactc agtcagctcc ccaccgacgc     4500

cggcccccac taggcgagga cagcattggt ctcaaggcac tgaagccaaa ggcagaagtt     4560

gatgaggatg gagttgtgat gtgctcaggc cctgaggagg gagaggaggt gggccaggct     4620

gaagaaacag gcccaccctc cacgtgccag ctctggtctc tgagtggtgg ctgtggggcg     4680

ctccctcagg cagccatgct aactcctccc caggaatctg agatggaagc ccctgacctg     4740

gacacccgtg gacctgatgg ggtgacaccc ctgatgtcag cagtttgctg tggggaagta     4800

cagtccggga ccttccaagg ggcatggttg ggatgtcctg agccctggga acctctgctg     4860

gatggagggg cctgtcccca ggctcacacc gtgggcactg gggagacccc cctgcacctg     4920

gctgcccgat tctcccggcc aaccgctgcc cgccgcctcc ttgaggctgg agccaacccc     4980

aaccagccag accgggcagg gcgcacaccc cttcatgctg ctgtggctgc tgatgctcgg     5040

gaggtctgcc agcttctgct ccgtagcaga caaactgcag tggacgctcg cacagaggac     5100

gggaccacac ccttgatgct ggctgccagg ctggcggtgg aagacctggt tgaagaactg     5160

attgcagccc aagcagacgt gggggccaga gataaatggg ggaaaactgc gctgcactgg     5220

gctgctgccg tgaacaacgc ccgagccgcc cgctcgcttc tccaggccgg agccgataaa     5280

gatgcccagg acaacaggga gcagacgccg ctattcctgg cggcgcggga aggagcggtg     5340

gaagtagccc agctactgct ggggctgggg gcagcccgag agctgcggga ccaggctggg     5400

ctagcgccgg cggacgtcgc tcaccaacgt aaccactggg atctgctgac gctgctggaa     5460

ggggctgggc caccagaggc ccgtcacaaa gccacgccgg gccgcgaggc tgggcccttc     5520

ccgcgcgcac ggacggtgtc agtaagcgtg cccccgcatg ggggcggggc tctgccgcgc     5580

tgccggacgc tgtcagccgg agcaggccct cgtgggggcg gagcttgtct gcaggctcgg     5640

acttggtccg tagacttggc tgcgcggggg ggcggggcct attctcattg ccggagcctc     5700

tcgggagtag gagcaggagg aggcccgacc cctcgcggcc gtaggttttc tgcaggcatg     5760

cgcgggcctc ggcccaaccc tgcgataatg cgaggaagat acggagtggc tgccgggcgc     5820

ggaggcaggg tctcaacgga tgactggccc tgtgattggg tggccctggg agcttgcggt     5880

tctgcctcca acattccgat cccgcctcct tg                                   5912


<210> 2
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asn Tyr 
            20                  25                  30          


Trp Met Leu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Val Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Thr Gly Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 3
<211> 348
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
caggtccaac ttcaacagcc tggggctgag ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cacttttatc aattactgga tgctctgggt gaagcagagg      120

cctggacaag gccttgagtg gattggtatg attcatccta atagtgttag tactaactac      180

aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgg aactgggagg      300

gactactttg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210> 4
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Asn Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Phe 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Glu Met Tyr Tyr Asn Pro Val 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Glu Thr Ser Lys Thr Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Thr Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Arg Arg Arg Gly Leu Ala Met Asp Ser Trp Gly His Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210> 5
<211> 357
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcaatctg       60

acttgttctt tctctgggtt ttcactgagc acttttggta tgggtgtggg ctggattcgt      120

cagccttcag ggaagggtct ggagtggctg gcacacattt ggtgggatga tgaaatgtac      180

tataacccag tcctgaagag tcggctcaca atctccaagg aaacctccaa aacccaggta      240

ttcctcaaga tcgccactgt ggacactgca gatactgcca catattactg tgttcgaaga      300

cgacgcgggt tggctatgga ctcctggggt cacggaacct cagtcaccgt ctcctca         357


<210> 6
<211> 112
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Arg Gly 
            20                  25                  30          


Phe Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
            100                 105                 110         


<210> 7
<211> 336
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agaggttttt actggaactg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tacataagct acgacggtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgcagttga attctgtgac tactgaggac acagctacat attactgtgc aaggatggac      300

tactggggtc aaggaacctc agtcaccgtc tcctca                                336


<210> 8
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 9
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattggcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcagcaa tatagcagct atccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210> 10
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210> 11
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


<210> 12
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Thr Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Ile Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Ser Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210> 13
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
gacattgtga tgacccagtc tcacaaattc atgtccacat caataggaga cagggtcaac       60

atcacctgca aggccagtca ggatgtgact actgctgtag cctggtatca acagaaacca      120

ggacaatctc ctaaactact gatttactcg gcatcctacc gatacactgg aatccctgat      180

cgcttcactg gcactggatc tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cactttatta ctgtcagcaa cattctaata ctccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210> 14
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Leu His Trp Tyr Gln Gln Lys Ser Glu Thr Ser Pro Lys Pro Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210> 15
<211> 324
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagctc aagtataagt tccagcaact tgcactggta ccagcagaag      120

tcagaaacct cccccaaacc ctggatttat ggcacatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttacccatt cacgttcggc      300

tcggggacaa agttggaaat aaaa                                             324


<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Tyr Thr Phe Ile Asn Tyr Trp 
1               5               


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ile His Pro Asn Ser Val Ser Thr 
1               5               


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Thr Gly Arg Asp Tyr Phe Asp Tyr 
1               5                   


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gln Asp Val Gly Thr Ala 
1               5       


<210> 20
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Trp Ala Ser 
1           


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gln Gln Tyr Ser Ser Tyr Pro Phe Thr 
1               5                   


<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Ala Tyr Thr Phe Ser Asp His Ser 
1               5               


<210> 23
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ile Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210> 24
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Thr Arg Gly Gly His Tyr Phe Phe Asp Tyr 
1               5                   10  


<210> 25
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gln Asp Ile Ser Asn Tyr 
1               5       


<210> 26
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Tyr Thr Ser 
1           


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210> 28
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Gly Phe Ser Leu Ser Thr Phe Gly Met Gly 
1               5                   10  


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Ile Trp Trp Asp Asp Glu Met 
1               5           


<210> 30
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Val Arg Arg Arg Arg Gly Leu Ala Met Asp Ser 
1               5                   10      


<210> 31
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Gln Asp Val Thr Thr Ala 
1               5       


<210> 32
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Ser Ala Ser 
1           


<210> 33
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Gln Gln His Ser Asn Thr Pro Leu Thr 
1               5                   


<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gly Tyr Ser Ile Thr Arg Gly Phe Tyr 
1               5                   


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Ile Ser Tyr Asp Gly Ser Asn 
1               5           


<210> 36
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ala Arg Met Asp Tyr 
1               5   


<210> 37
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ser Ser Ile Ser Ser Ser Asn 
1               5           


<210> 38
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Gly Thr Ser 
1           


<210> 39
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
1               5                   


<210> 40
<211> 224
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Arg Ser Gln Phe Ser Leu Gln Leu Leu Ser Thr Gln Asp Leu Thr 
1               5                   10                  15      


Val Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
            20                  25                  30          


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys 
        35                  40                  45              


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
    50                  55                  60                  


Ile Asn Tyr Trp Met Leu Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
65                  70                  75                  80  


Glu Trp Ile Gly Met Ile His Pro Asn Ser Val Ser Thr Asn Tyr Asn 
                85                  90                  95      


Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
            100                 105                 110         


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
        115                 120                 125             


Tyr Tyr Cys Gly Thr Gly Arg Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 
    130                 135                 140                 


Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
145                 150                 155                 160 


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
            180                 185                 190         


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
    210                 215                 220                 


<210> 41
<211> 672
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 41
atgagatcac agttctctct acagttactg agcacacagg acctcacagt gggatggagc       60

tatatcatcc tctttttggt agcaacagct acaggtgtcc actcccaggt ccaacttcaa      120

cagcctgggg ctgagctggt aaagcctggg gcttcagtga agttgtcctg caaggcttct      180

ggctacactt ttatcaatta ctggatgctc tgggtgaagc agaggcctgg acaaggcctt      240

gagtggattg gtatgattca tcctaatagt gttagtacta actacaatga gaagttcaag      300

agcaaggcca cactgactgt agacaaatcc tccagcacag cctacatgca actcagcagc      360

ctgacatctg aggactctgc ggtctattac tgtggaactg ggagggacta ctttgactac      420

tggggccaag gcaccactct cacagtctcc tcagccaaaa cgacaccccc atctgtctat      480

ccactggccc ctggatctgc tgcccaaact aactccatgg tgaccctggg atgcctggtc      540

aagggctatt tccctgagcc agtgacagtg acctggaact ctggatccct gtccagcggt      600

gtgcacacct tcccagctgt cctgcagtct gacctctaca ctctgagcag ctcagtgact      660

gtcccctcca gc                                                          672


<210> 42
<211> 211
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Gly Arg Leu Thr Ser Ser Phe Leu Leu Leu Thr Val Pro Ala Tyr 
1               5                   10                  15      


Val Leu Ser Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          


Pro Ser Gln Thr Leu Asn Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              


Ser Thr Phe Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Leu Ala His Ile Trp Trp Asp Asp Glu Met Tyr Tyr 
65                  70                  75                  80  


Asn Pro Val Leu Lys Ser Arg Leu Thr Ile Ser Lys Glu Thr Ser Lys 
                85                  90                  95      


Thr Gln Val Phe Leu Lys Ile Ala Thr Val Asp Thr Ala Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Val Arg Arg Arg Arg Gly Leu Ala Met Asp Ser Trp 
        115                 120                 125             


Gly His Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro 
    130                 135                 140                 


Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met 
145                 150                 155                 160 


Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
        195                 200                 205             


Pro Ser Ser 
    210     


<210> 43
<211> 635
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 43
atgggcaggc ttacttcttc attcctgtta ctgactgtcc ctgcatatgt cctgtcccag       60

gttactctga aagagtctgg ccctgggata ttgcagccct cccagaccct caatctgact      120

tgttctttct ctgggttttc actgagcact tttggtatgg gtgtgggctg gattcgtcag      180

ccttcaggga agggtctgga gtggctggca cacatttggt gggatgatga aatgtactat      240

aacccagtcc tgaagagtcg gctcacaatc tccaaggaaa cctccaaaac ccaggtattc      300

ctcaagatcg ccactgtgga cactgcagat actgccacat attactgtgt tcgaagacga      360

cgcgggttgg ctatggactc ctggggtcac ggaacctcag tcaccgtctc ctcagccaaa      420

acgacacccc catctgtcta tccactggcc cctggatctg ctgcccaaac taactccatg      480

gtgaccctgg gatgcctggt caagggctat ttccctgagc cagtgacagt gacctggaac      540

tctggatccc tgtccagcgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac      600

actctgagca gctcagtgac tgtcccctcc agctg                                 635


<210> 44
<211> 203
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Arg Gly Phe Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
        115                 120                 125             


Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
    130                 135                 140                 


Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
                165                 170                 175     


Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr 
            180                 185                 190         


Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
        195                 200             


<210> 45
<211> 611
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 45
atgaaagtgt tgagtctgtt gtacctgttg acagccattc ctggtatcct gtctgatgta       60

cagcttcagg agtcaggacc tggcctcgtg aaaccttctc agtctctgtc tctcacctgc      120

tctgtcactg gctactccat caccagaggt ttttactgga actggatccg gcagtttcca      180

ggaaacaaac tggaatggat gggctacata agctacgacg gtagcaataa ctacaaccca      240

tctctcaaaa atcgaatctc catcactcgt gacacatcta agaaccagtt tttcctgcag      300

ttgaattctg tgactactga ggacacagct acatattact gtgcaaggat ggactactgg      360

ggtcaaggaa cctcagtcac cgtctcctca gccaaaacga cacccccatc tgtctatcca      420

ctggcccctg gatctgctgc ccaaactaac tccatggtga ccctgggatg cctggtcaag      480

ggctatttcc ctgagccagt gacagtgacc tggaactctg gatccctgtc cagcggtgtg      540

cacaccttcc cagctgtcct gcagtctgac ctctacactc tgagcagctc agtgactgtc      600

ccctccagct g                                                           611


<210> 46
<211> 203
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Glu Thr His Ser Gln Val Phe Val Tyr Thr Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Glu Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser 
            100                 105                 110         


Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200             


<210> 47
<211> 609
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 47
atggagacac attctcaggt ctttgtatac acgttgctgt ggttgtctgg tgttgaagga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcagc      120

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      180

gggcaatctc ctaaactact gatttactgg gcatccaccc ggcacactgg agtccctgat      240

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattggcaa tgtgcagtct      300

gaagacttgg cagattattt ctgtcagcaa tatagcagct atccattcac gttcggctcg      360

gggacaaagt tggaaataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaag                                                              609


<210> 48
<211> 202
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln Gly 
1               5                   10                  15      


Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile 
        35                  40                  45              


Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn 
                85                  90                  95      


Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr 
            100                 105                 110         


Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200         


<210> 49
<211> 606
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 49
atgtcctctg ctcagttcct tggtctcctg ttgctctgtt ttcaaggtac cagatgtgat       60

atccagatga cacagactac atcctccctg tctgcctctc tgggagacag agtcaccatc      120

agttgcaggg caagtcagga cattagcaat tatttaaact ggtatcagca gaaaccagat      180

ggaactgtta aactcctgat ctactacaca tcaagattac actcaggagt cccatcaagg      240

ttcagtggca gtgggtctgg aacagattat tctctcacca ttagcaacct ggagcaagaa      300

gatattgcca cttacttttg ccaacagggt aatacgcttc cgtggacgtt cggtggaggc      360

accaagctgg aaatcaaacg ggctgatgct gcaccaactg tatccatctt cccaccatcc      420

agtgagcagt taacatctgg aggtgcctca gtcgtgtgct tcttgaacaa cttctacccc      480

aaagacatca atgtcaagtg gaagattgat ggcagtgaac gacaaaatgg cgtcctgaac      540

agttggactg atcaggacag caaagacagc acctacagca tgagcagcac cctcacgttg      600

accaag                                                                 606


<210> 50
<211> 203
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Glu Ser Gln Ile Gln Val Phe Val Phe Val Phe Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Ile Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Val Thr Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Thr Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Thr Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Ser 
            100                 105                 110         


Asn Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200             


<210> 51
<211> 609
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
atggagtcac agattcaggt ctttgtattc gtgtttctct ggttgtctgg tgttgacgga       60

gacattgtga tgacccagtc tcacaaattc atgtccacat caataggaga cagggtcaac      120

atcacctgca aggccagtca ggatgtgact actgctgtag cctggtatca acagaaacca      180

ggacaatctc ctaaactact gatttactcg gcatcctacc gatacactgg aatccctgat      240

cgcttcactg gcactggatc tgggacggat ttcactttca ccatcagcac tgtgcaggct      300

gaagacctgg cactttatta ctgtcagcaa cattctaata ctccgctcac gttcggtgct      360

gggaccaagc tggagctgaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaag                                                              609


<210> 52
<211> 206
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 52
Met Asp Phe His Val Gln Ile Phe Ser Phe Met Leu Ile Ser Val Thr 
1               5                   10                  15      


Val Ile Leu Ser Ser Gly Glu Ile Val Leu Thr Gln Ser Pro Ala Leu 
            20                  25                  30          


Met Ala Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Val Ser 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Asn Leu His Trp Tyr Gln Gln Lys Ser Glu 
    50                  55                  60                  


Thr Ser Pro Lys Pro Trp Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly 
65                  70                  75                  80  


Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln Trp Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser 
    130                 135                 140                 


Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser 
                165                 170                 175     


Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205     


<210> 53
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 53
atggattttc atgtgcagat tttcagcttc atgctaatca gtgtcacagt catattgtcc       60

agtggagaaa ttgtgctcac ccagtctcca gcactcatgg ctgcatctcc aggggagaag      120

gtcaccatca cctgcagtgt cagctcaagt ataagttcca gcaacttgca ctggtaccag      180

cagaagtcag aaacctcccc caaaccctgg atttatggca catccaacct ggcttctgga      240

gtccctgttc gcttcagtgg cagtggatct gggacctctt attctctcac aatcagcagc      300

atggaggctg aagatgctgc cacttattac tgtcaacagt ggagtagtta cccattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa cgggctgatg ctgcaccaac tgtatccatc      420

ttcccaccat ccagtgagca gttaacatct ggaggtgcct cagtcgtgtg cttcttgaac      480

aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga acgacaaaat      540

ggcgtcctga acagttggac tgatcaggac agcaaagaca gcacctacag catgagcagc      600

accctcacgt tgaccaag                                                    618


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 54
gggggaagct ctccactaga                                                   20


<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 55
gttgtgtgct gatttggccc                                                   20


<210> 56
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 56
cggtccaaat tcctgctga                                                    19


<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 57
cattgggttc cttccatcca                                                   20


