               SEQUENCE LISTING

<110> Kantonsspital St. Gallen

<120> Antibodies or antigen-binding fragments specifically binding to Gremlin-1 and uses thereof

<130> AD3408 PCT BS

<150> EP21 200 201.8
<151> 2021-09-30
<150> EP21 161 106.6
<151> 2021-03-05
<150> EP20 202 900.5
<151> 2020-10-20

<160> 98

<170> BiSSAP 1.3.6

<210> 1
<211> 285
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 14-D10-2

<400> 1
ggttactcat tcactggcta ctacatgcac tgggtgaaac agagccatgg aaatatcctc     60

gattggattg gatatttttt tccttacaat ggtttttcta actgcaacca gaaattcaag    120

ggcaaggcca cattgactgt agacaagtcc tctagcacag cctacatgga gctccgcagc    180

ctgacatctg aggactctgc agtctattac tgtgcaagag ggggactggg acggggatac    240

ttcgatgtct ggggcacagg gaccacggtc accgtctcct cagcc                    285


<210> 2
<211> 95
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 14-D10-2

<400> 2
Gly Tyr Ser Phe Thr Gly Tyr Tyr Met His Trp Val Lys Gln Ser His 
1               5                   10                  15      
Gly Asn Ile Leu Asp Trp Ile Gly Tyr Phe Phe Pro Tyr Asn Gly Phe 
            20                  25                  30          
Ser Asn Cys Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp 
        35                  40                  45              
Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu 
    50                  55                  60                  
Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gly Gly Leu Gly Arg Gly Tyr 
65                  70                  75                  80  
Phe Asp Val Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser Ala 
                85                  90                  95  

<210> 3
<211> 249
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 14-E6-3

<400> 3
ggctacattt tcacaaacta tggtataagc tgggtgaagc agagaactgg acagggcctt     60

gagtggattg gagagattta tcctagaagt ggtaaaactt actacaatga gaagttcaag    120

ggcaaggcca cactgactgc agacaaatcc tccagaacag cgtacatgga gttccgcagc    180

ctgacatctg aggagtctgc ggtctatttc tgtgcaagac aggactactg gggccaaggc    240

accactctc                                                            249


<210> 4
<211> 83
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 14-E6-3

<400> 4
Gly Tyr Ile Phe Thr Asn Tyr Gly Ile Ser Trp Val Lys Gln Arg Thr 
1               5                   10                  15      
Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Tyr Pro Arg Ser Gly Lys 
            20                  25                  30          
Thr Tyr Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp 
        35                  40                  45              
Lys Ser Ser Arg Thr Ala Tyr Met Glu Phe Arg Ser Leu Thr Ser Glu 
    50                  55                  60                  
Glu Ser Ala Val Tyr Phe Cys Ala Arg Gln Asp Tyr Trp Gly Gln Gly 
65                  70                  75                  80  
Thr Thr Leu 
            

<210> 5
<211> 294
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 17-C3-2

<400> 5
cctggggctt cagtgaagat atcctgtaag gcttctggat acacgttcac tgactactac     60

atgaactggg tgaagcagag ccatggaaag agccttgagt ggattggaga tattaatcct    120

aacaatggtg gtactaacta caaccagaag ttcaagggta aggccacatt gactgtagac    180

aagtcctcca gtacagccta catggagttc cgcagcctga catctgagga ctctgcagtc    240

tattactgtg caagagaccc gatctaccat gactacgacg gggacatacc tatg          294


<210> 6
<211> 98
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 17-C3-2

<400> 6
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
1               5                   10                  15      
Thr Asp Tyr Tyr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
            20                  25                  30          
Glu Trp Ile Gly Asp Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn 
        35                  40                  45              
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
    50                  55                  60                  
Thr Ala Tyr Met Glu Phe Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
65                  70                  75                  80  
Tyr Tyr Cys Ala Arg Asp Pro Ile Tyr His Asp Tyr Asp Gly Asp Ile 
                85                  90                  95      
Pro Met 
        

<210> 7
<211> 324
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 20-D1-5

<400> 7
cctggggctt cagtgaagtt gtcctgcaag gcttctggct acactttcac cagctactgg      60

atgcactgga tgaagcagag gcctggacaa ggccttgagt ggattggaat gattcatctt     120

aatagtggta gtactaacta caatgagaag ttcaagagca aggccacact gactgtagac     180

aaatcctcca gcacagccta catgcaactc agcagcctga catctgagga ctctgcggtc     240

tattactgtg caagaagagg ctataggtat tactacggta gtagctacga ggactacttt     300

gactactggg gccaaggcac cact                                            324


<210> 8
<211> 108
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 20-D1-5

<400> 8
Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
1               5                   10                  15      
Thr Ser Tyr Trp Met His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu 
            20                  25                  30          
Glu Trp Ile Gly Met Ile His Leu Asn Ser Gly Ser Thr Asn Tyr Asn 
        35                  40                  45              
Glu Lys Phe Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
    50                  55                  60                  
Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
65                  70                  75                  80  
Tyr Tyr Cys Ala Arg Arg Gly Tyr Arg Tyr Tyr Tyr Gly Ser Ser Tyr 
                85                  90                  95      
Glu Asp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105             

<210> 9
<211> 249
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 3-A1-3

<400> 9
tctggcaaca ctttcaccag ctactggatg cactgggtga agcagaggcc tggacaaggc     60

cttgagtgga ttggaatgat tcatcctaat agtggtaata cttattacaa tgagaagttc    120

aagagcaaga ccactctgac tgtagacaaa tcctccagca cagcctacat gcaactcagc    180

agcctgacat ctgaggactc tgcggtctat tactgtgcaa gatcgagggg cttatactac    240

ggtagtctt                                                            249


<210> 10
<211> 83
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 3-A1-3

<400> 10
Ser Gly Asn Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg 
1               5                   10                  15      
Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile His Pro Asn Ser Gly 
            20                  25                  30          
Asn Thr Tyr Tyr Asn Glu Lys Phe Lys Ser Lys Thr Thr Leu Thr Val 
        35                  40                  45              
Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
    50                  55                  60                  
Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Arg Gly Leu Tyr Tyr 
65                  70                  75                  80  
Gly Ser Leu 
            

<210> 11
<211> 309
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 8-H2-2

<400> 11
cagcctaaag gatcattgaa actctcatgt gccgcctctg gtttcacctt caatacctat     60

gccatgcact gggtccgcca ggctccagga aagggtttgg aatgggttgc tcgcataaga    120

agtaaaagta gtaattttgc aacatattat gccgattcag tgaaagacag attcaccatc    180

tccagagatg attcacaaag catgctctat ctgcaaatga acaacctgaa aactgaggac    240

acagccatgt attactgtgt gagaggttac tggtacttcg atgtctgggg cacagggacc    300

acggtcacc                                                            309


<210> 12
<211> 103
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 8-H2-2

<400> 12
Gln Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr 
1               5                   10                  15      
Phe Asn Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
            20                  25                  30          
Leu Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Ser Asn Phe Ala Thr 
        35                  40                  45              
Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
    50                  55                  60                  
Ser Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
65                  70                  75                  80  
Thr Ala Met Tyr Tyr Cys Val Arg Gly Tyr Trp Tyr Phe Asp Val Trp 
                85                  90                  95      
Gly Thr Gly Thr Thr Val Thr 
            100             

<210> 13
<211> 297
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 12-G9-12

<400> 13
tgcagggctt ctggctacac cttcaccagc tactgggtgc actgggtgaa acagaggcct     60

ggacaaggcc ttgagtgggt tggagatatt catcctaccg atggtggtac tcactacaat    120

gagaagttca agaccaaggc cacactgact gtagacaaat cctccagcac agcctacatg    180

cagctcagca gcctgacatc tgaggactct gcggtctatt attgtgcaag acaggggatt    240

aactggtttg cttactgggg ccaagggact ctggtcactg tctctgcagc caaaacg       297


<210> 14
<211> 99
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 12-G9-12

<400> 14
Cys Arg Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Val His Trp Val 
1               5                   10                  15      
Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Val Gly Asp Ile His Pro 
            20                  25                  30          
Thr Asp Gly Gly Thr His Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr 
        35                  40                  45              
Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser 
    50                  55                  60                  
Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Gln Gly Ile 
65                  70                  75                  80  
Asn Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
                85                  90                  95      
Ala Lys Thr 
            

<210> 15
<211> 333
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 7-H12-1

<400> 15
cctggggctt cagtgaagat gtcctgcaag gcttctggct acacattcac tgacttctac      60

attcattggg tgaaacagag ccatggaaag agccttgagt ggattggata tatttatcct     120

aacaatggta ataatggcta caaccagaag ttcaagggca aggccacatt gactgtagac     180

aagtcctcca gtacagccta catggagctc cgcagcctga catctgagga ctctgcagtc     240

tattattgtg caagacgtga tggccccgcc tggtttgttt actggggcca aggggctctg     300

gtcactgtct ctgcagccaa aacgacaccc cca                                  333


<210> 16
<211> 111
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 7-H12-1

<400> 16
Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
1               5                   10                  15      
Thr Asp Phe Tyr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
            20                  25                  30          
Glu Trp Ile Gly Tyr Ile Tyr Pro Asn Asn Gly Asn Asn Gly Tyr Asn 
        35                  40                  45              
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
    50                  55                  60                  
Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
65                  70                  75                  80  
Tyr Tyr Cys Ala Arg Arg Asp Gly Pro Ala Trp Phe Val Tyr Trp Gly 
                85                  90                  95      
Gln Gly Ala Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro 
            100                 105                 110     

<210> 17
<211> 294
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 14-D10-2

<400> 17
acccagtctc catcctactt gtctgtatct ctaggaggca gagtcaccat tacttgcaag     60

gcaagtgacc acattaataa ttggttagcc tggtatcagc agaaaccagg aaatgctcct    120

aggctcttaa tatctggtgc aaccagtttg gaaactgggg ttccttcaag attcagtggc    180

agtggatctg gaaaggatta cactctcagc attaccagtc ttcagactga agatgttgct    240

acttattact gtcaacagta ttggagtagt cctcggacgt tcggtggagg cacc          294


<210> 18
<211> 98
<212> PRT
<213> Artificial Sequence


<220> 
<223> light chain recombinant sequence of 14-D10-2

<400> 18
Thr Gln Ser Pro Ser Tyr Leu Ser Val Ser Leu Gly Gly Arg Val Thr 
1               5                   10                  15      
Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp Leu Ala Trp Tyr 
            20                  25                  30          
Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile Ser Gly Ala Thr 
        35                  40                  45              
Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  
Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr Glu Asp Val Ala 
65                  70                  75                  80  
Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ser Pro Arg Thr Phe Gly Gly 
                85                  90                  95      
Gly Thr 
        

<210> 19
<211> 288
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 14-E6-3

<400> 19
cagtctccag caatcatgtc tgcatctcca ggggagaagg tcaccatgac ctgcagtgcc     60

agctcaagta taaattacat gcactggtac cagcagaagc caggcacctc ccccaaaaga    120

tggatttatg acacatccaa actggcttct ggagtccctg ctcgcttcag tggcagtggg    180

tctgggacct cttattctct cacaatcagc agcatggagg ctgaagatgc tgccacttat    240

tactgccatc agcggagtag ttacccattc acgttcggct cggggaca                 288


<210> 20
<211> 96
<212> PRT
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 14-E6-3

<400> 20
Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
1               5                   10                  15      
Thr Cys Ser Ala Ser Ser Ser Ile Asn Tyr Met His Trp Tyr Gln Gln 
            20                  25                  30          
Lys Pro Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu 
        35                  40                  45              
Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
    50                  55                  60                  
Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr 
65                  70                  75                  80  
Tyr Cys His Gln Arg Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr 
                85                  90                  95      



<210> 21
<211> 315
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 17-C3-2

<400> 21
acccagtctc cactctccct gcctgtcagt cttggagatc aagcctccat ctcttgcaga     60

tctagtcaga gccttgtaca cagtaatgga aacacctatt tacattggtg cctgcagaag    120

ccaggccagt ctccaaagct cctgatctac aaagtttcca accgattttc tggggtccca    180

gacaggttca gtggcagtgg atcagggaca gatttcacac tcaagatcag cagagtggag    240

gctgaggatc tgggagttta tttctgctct caaagtacac atgttccgct cacgttcggt    300

gctgggacca agctg                                                     315


<210> 22
<211> 105
<212> PRT
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 17-C3-2

<400> 22
Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
1               5                   10                  15      
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
            20                  25                  30          
Tyr Leu His Trp Cys Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
65                  70                  75                  80  
Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro 
                85                  90                  95      
Leu Thr Phe Gly Ala Gly Thr Lys Leu 
            100                 105 

<210> 23
<211> 312
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 20-D1-5

<400> 23
acccagtctc cactctccct gcctgtcagt cttggagatc aagcctccat ctcttgcaga     60

tctagtcaga ggattgtaca tagtaatgga aacacctatt tagaatggta cctgcagaaa    120

ccaggccagt ctccaaagct cctgatctac aaagtttcca accgattttc tggggtccca    180

gacaggttca gtggcagtgg atcagggaca gatttcacac tcaagatcag cagagtggag    240

gctgaggatc tgggagttta ttactgcttt caaggttcac atgttccgta cacgttcgga    300

ggggggacca ag                                                        312


<210> 24
<211> 104
<212> PRT
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 20-D1-5

<400> 24
Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
1               5                   10                  15      
Ile Ser Cys Arg Ser Ser Gln Arg Ile Val His Ser Asn Gly Asn Thr 
            20                  25                  30          
Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
65                  70                  75                  80  
Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro 
                85                  90                  95      
Tyr Thr Phe Gly Gly Gly Thr Lys 
            100                 

<210> 25
<211> 309
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 3-A1-3

<400> 25
ccactctccc tgcctgtcag tcttggagat caagcctcca tctcttgcag atctagtcag     60

agccttgtac acagtaatgg aaacacctat ttacattggt atctgcagaa gtcaggccag    120

tctccaaagc tcctgatcta caaagtttcc aaccgatttt ctggggtccc agacaggttc    180

agtggcagtg gatcagggac agatttcaca ctcaagatca gcagagtgga ggctgaggat    240

ctgggagttt atttctgctc tcaaagtaca catgttccgt acacgttcgg aggggggacc    300

aagctggaa                                                            309


<210> 26
<211> 103
<212> PRT
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 3-A1-3

<400> 26
Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys 
1               5                   10                  15      
Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
            20                  25                  30          
Trp Tyr Leu Gln Lys Ser Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys 
        35                  40                  45              
Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
    50                  55                  60                  
Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp 
65                  70                  75                  80  
Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Tyr Thr Phe 
                85                  90                  95      
Gly Gly Gly Thr Lys Leu Glu 
            100             

<210> 27
<211> 303
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 8-H2-2

<400> 27
tctccatcct cactgtctgc atctctggga ggcaaagtca ccatcacttg caaggcaagc     60

caagacatta acaagtatat agcttggtac caacacaagc ctggaaaagg tcctaggctg    120

ctcatacatt acacatctac attacagcca ggcatcccat caaggttcag tggaagtggg    180

tctgggagac atttttcctt cagcatcagc aacctggagc ctgaagatat tgcaacttat    240

tattgtctac agtatgataa tcttctaccc acgttcggag gggggaccaa gctggaaata    300

aaa                                                                  303


<210> 28
<211> 101
<212> PRT
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 8-H2-2

<400> 28
Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly Gly Lys Val Thr Ile Thr 
1               5                   10                  15      
Cys Lys Ala Ser Gln Asp Ile Asn Lys Tyr Ile Ala Trp Tyr Gln His 
            20                  25                  30          
Lys Pro Gly Lys Gly Pro Arg Leu Leu Ile His Tyr Thr Ser Thr Leu 
        35                  40                  45              
Gln Pro Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Arg His 
    50                  55                  60                  
Phe Ser Phe Ser Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr 
65                  70                  75                  80  
Tyr Cys Leu Gln Tyr Asp Asn Leu Leu Pro Thr Phe Gly Gly Gly Thr 
                85                  90                  95      
Lys Leu Glu Ile Lys 
            100     

<210> 29
<211> 282
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 12-G9-12

<400> 29
tctccagcaa tcatgtctgc atctctaggg gaacgggtca ccatgacctg cactgccagc     60

tcaagtgtaa gttccagtta cttacactgg taccagcaga agccaggatc ctcccccaaa    120

ctctggattt atagcacatc caacctggct tctggagtcc cagctcgctt cagtggcagt    180

gggtctggga cctcttactc tctcacaatc agcagcatgg aggctgaaga tgctgccact    240

tattactgcc accagtatca tcgttccccg ctcacgttcg gt                       282


<210> 30
<211> 94
<212> PRT
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 12-G9-12

<400> 30
Ser Pro Ala Ile Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr 
1               5                   10                  15      
Cys Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln 
            20                  25                  30          
Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn 
        35                  40                  45              
Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  
Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr 
65                  70                  75                  80  
Tyr Tyr Cys His Gln Tyr His Arg Ser Pro Leu Thr Phe Gly 
                85                  90                  

<210> 31
<211> 309
<212> DNA
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 7-H12-1

<400> 31
acccagtctc cactctccct gcctgtcagt cttggagatc aagcctccat ctcttgcaga     60

tctagtcaga gccttgtaca cagtaatgga aacacctatt tacattggtg cctgcagaag    120

ccaggccagt ctccaaagct cctgatctac aaagtttcca accgattttc tggggtccca    180

gacaggttca gtggcagtgg atcagggaca gatttcacac tcaagatcag cagagtggag    240

gctgaggatc tgggagttta tttctgctct caaagtacac atgttccgct cacgttcggt    300

gctgggacc                                                            309


<210> 32
<211> 103
<212> PRT
<213> Artificial Sequence


<220> 
<223> LC recombinant sequence of 7-H12-1

<400> 32
Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
1               5                   10                  15      
Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr 
            20                  25                  30          
Tyr Leu His Trp Cys Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
        35                  40                  45              
Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
65                  70                  75                  80  
Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro 
                85                  90                  95      
Leu Thr Phe Gly Ala Gly Thr 
            100             

<210> 33
<211> 184
<212> PRT
<213> Homo sapiens


<220> 
<223> human Gremlin-1

<400> 33
Met Ser Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      
Thr Leu Leu Pro Ala Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          
Ile Pro Pro Pro Asp Lys Ala Gln His Asn Asp Ser Glu Gln Thr Gln 
        35                  40                  45              
Ser Pro Gln Gln Pro Gly Ser Arg Asn Arg Gly Arg Gly Gln Gly Arg 
    50                  55                  60                  
Gly Thr Ala Met Pro Gly Glu Glu Val Leu Glu Ser Ser Gln Glu Ala 
65                  70                  75                  80  
Leu His Val Thr Glu Arg Lys Tyr Leu Lys Arg Asp Trp Cys Lys Thr 
                85                  90                  95      
Gln Pro Leu Lys Gln Thr Ile His Glu Glu Gly Cys Asn Ser Arg Thr 
            100                 105                 110         
Ile Ile Asn Arg Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro 
        115                 120                 125             
Arg His Ile Arg Lys Glu Glu Gly Ser Phe Gln Ser Cys Ser Phe Cys 
    130                 135                 140                 
Lys Pro Lys Lys Phe Thr Thr Met Met Val Thr Leu Asn Cys Pro Glu 
145                 150                 155                 160 
Leu Gln Pro Pro Thr Lys Lys Lys Arg Val Thr Arg Val Lys Gln Cys 
                165                 170                 175     
Arg Cys Ile Ser Ile Asp Leu Asp 
            180                 

<210> 34
<211> 184
<212> PRT
<213> Mus musculus


<220> 
<223> murine Gemlin-1

<400> 34
Met Asn Arg Thr Ala Tyr Thr Val Gly Ala Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      
Thr Leu Leu Pro Thr Ala Glu Gly Lys Lys Lys Gly Ser Gln Gly Ala 
            20                  25                  30          
Ile Pro Pro Pro Asp Lys Ala Gln His Asn Asp Ser Glu Gln Thr Gln 
        35                  40                  45              
Ser Pro Pro Gln Pro Gly Ser Arg Thr Arg Gly Arg Gly Gln Gly Arg 
    50                  55                  60                  
Gly Thr Ala Met Pro Gly Glu Glu Val Leu Glu Ser Ser Gln Glu Ala 
65                  70                  75                  80  
Leu His Val Thr Glu Arg Lys Tyr Leu Lys Arg Asp Trp Cys Lys Thr 
                85                  90                  95      
Gln Pro Leu Lys Gln Thr Ile His Glu Glu Gly Cys Asn Ser Arg Thr 
            100                 105                 110         
Ile Ile Asn Arg Phe Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro 
        115                 120                 125             
Arg His Ile Arg Lys Glu Glu Gly Ser Phe Gln Ser Cys Ser Phe Cys 
    130                 135                 140                 
Lys Pro Lys Lys Phe Thr Thr Met Met Val Thr Leu Asn Cys Pro Glu 
145                 150                 155                 160 
Leu Gln Pro Pro Thr Lys Lys Lys Arg Val Thr Arg Val Lys Gln Cys 
                165                 170                 175     
Arg Cys Ile Ser Ile Asp Leu Asp 
            180                 

<210> 35
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 14-D10-2

<400> 35
Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               

<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 14-D10-2

<400> 36
Phe Phe Pro Tyr Asn Gly Phe Ser 
1               5               

<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 14-D10-2

<400> 37
Ala Arg Gly Gly Leu Gly Arg Gly Tyr Phe Asp Val 
1               5                   10          

<210> 38
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 14-D10-2

<400> 38
Asp His Ile Asn Asn Trp 
1               5       

<210> 39
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 14-D10-2

<400> 39
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
1               5                   10                  15      
Ser 
    

<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 14-D10-2

<400> 40
Gln Gln Tyr Trp Ser Ser Pro Arg Thr 
1               5                   

<210> 41
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 20-D1-5

<400> 41
Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               

<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 20-D1-5

<400> 42
Ile His Leu Asn Ser Gly Ser Thr 
1               5               

<210> 43
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 20-D1-5

<400> 43
Ala Arg Arg Gly Tyr Arg Tyr Tyr Tyr Gly Ser Ser Tyr Glu Asp Tyr 
1               5                   10                  15      
Phe Asp Tyr 
            

<210> 44
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 20-D1-5

<400> 44
Gln Arg Ile Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 45
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 20-D1-5

<220> 
<221> VARIANT
<222> 4
<223> can be any amino acid

<400> 45
Lys Val Ser Xaa 
1               

<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 20-D1-5

<400> 46
Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   

<210> 47
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 17-C3-2

<400> 47
Gly Tyr Thr Phe Thr Asp Tyr Tyr 
1               5               

<210> 48
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 17-C3-2

<400> 48
Ile Asn Pro Asn Asn Gly Gly Thr 
1               5               

<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 17-C3-2

<400> 49
Ala Arg Asp Pro Ile Tyr His Asp Tyr Asp Gly Asp Ile Pro Met 
1               5                   10                  15  

<210> 50
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 17-C3-2

<400> 50
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 51
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 17-C3-2

<220> 
<221> VARIANT
<222> 4
<223> can be any amino acid

<400> 51
Lys Val Ser Xaa 
1               

<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 17-C3-2

<400> 52
Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   

<210> 53
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 14-E6-3

<400> 53
Gly Tyr Ile Phe Thr Asn Tyr Gly 
1               5               

<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 14-E6-3

<400> 54
Ile Tyr Pro Arg Ser Gly Lys Thr 
1               5               

<210> 55
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 14-E6-3

<400> 55
Ala Arg Gln Asp Tyr 
1               5   

<210> 56
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 14-E6-3

<400> 56
Ser Ser Ile Asn Tyr 
1               5   

<210> 57
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 14-E6-3

<220> 
<221> VARIANT
<222> 4
<223> can be any amino acid

<400> 57
Asp Thr Ser Xaa 
1               

<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 14-E6-3

<400> 58
His Gln Arg Ser Ser Tyr Pro Phe Thr 
1               5                   

<210> 59
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 3-A1-3

<400> 59
Gly Asn Thr Phe Thr Ser Tyr Trp 
1               5               

<210> 60
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 3-A1-3

<400> 60
Ile His Pro Asn Ser Gly Asn Thr 
1               5               

<210> 61
<211> 30
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 3-A1-3

<400> 61
Lys Thr Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      
Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            20                  25                  30  

<210> 62
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 3-A1-3

<400> 62
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 63
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 3-A1-3

<220> 
<221> VARIANT
<222> 4
<223> can be any amino acid

<400> 63
Lys Val Ser Xaa 
1               

<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 3-A1-3

<400> 64
Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   

<210> 65
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 8-H2-2

<400> 65
Gly Phe Thr Phe Asn Thr Tyr Ala Thr 
1               5                   

<210> 66
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 8-H2-2

<400> 66
Ile Arg Ser Lys Ser Ser Asn Phe Ala Thr 
1               5                   10  

<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 8-H2-2

<400> 67
Val Arg Gly Tyr Trp Tyr Phe Asp Val 
1               5                   

<210> 68
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 8-H2-2

<400> 68
Gln Asp Ile Asn Lys Tyr 
1               5       

<210> 69
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 8-H2-2

<220> 
<221> VARIANT
<222> 4
<223> can be any amino acid

<400> 69
Tyr Thr Ser Xaa 
1               

<210> 70
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 8-H2-2

<400> 70
Leu Gln Tyr Asp Asn Leu Leu Pro Thr 
1               5                   

<210> 71
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 12-G9-12

<400> 71
Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               

<210> 72
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 12-G9-12

<400> 72
Ile His Pro Thr Asp Gly Gly Thr 
1               5               

<210> 73
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 12-G9-12

<400> 73
Ala Arg Gln Gly Ile Asn Trp Phe Ala Tyr 
1               5                   10  

<210> 74
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 12-G9-12

<400> 74
Ser Ser Val Ser Ser Ser Tyr 
1               5           

<210> 75
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 12-G9-12

<220> 
<221> VARIANT
<222> 4
<223> can be any amino acid

<400> 75
Ser Thr Ser Xaa 
1               

<210> 76
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 12-G9-12

<400> 76
His Gln Tyr His Arg Ser Pro Leu Thr 
1               5                   

<210> 77
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 7-H12-1

<400> 77
Gly Tyr Thr Phe Thr Asp Phe Tyr 
1               5               

<210> 78
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 HC recombinant sequence of 7-H12-1

<400> 78
Ile Tyr Pro Asn Asn Gly Asn Asn 
1               5               

<210> 79
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 7-H12-1

<400> 79
Ala Arg Arg Asp Gly Pro Ala Trp Phe Val Tyr 
1               5                   10      

<210> 80
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 LC recombinant sequence of 7-H12-1

<400> 80
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      

<210> 81
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 7-H12-1

<220> 
<221> VARIANT
<222> 4
<223> can be any amino acid

<400> 81
Lys Val Ser Xaa 
1               

<210> 82
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 LC recombinant sequence of 7-H12-1

<400> 82
Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   

<210> 83
<211> 36
<212> DNA
<213> Artificial Sequence


<220> 
<223> IgG1

<400> 83
ggaagatcta tagacagatg ggggtgtcgt tttggc                               36


<210> 84
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> IgG2b

<400> 84
ggaagatcta ggggccagtg gatagactga tgg                                  33


<210> 85
<211> 32
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer MH1

<220> 
<221> variation
<222> 18
<223> /replace="a,c,g,t"

<400> 85
cttccggaat ccsargtnma gctgsagsag tc                                   32


<210> 86
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer MH2

<220> 
<221> variation
<222> 18
<223> /replace="a,c,g,t"

<400> 86
cttccggaat tcsargtnma gctgsagsag tcwgg                                35


<210> 87
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> 3KC

<400> 87
ggtgcatgcg gatacagttg gtgcagcatc                                     30


<210> 88
<211> 32
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer 5Mk

<400> 88
gggagctcga yattgtgmts acmcarwctm ca                                   32


<210> 89
<211> 18
<212> PRT
<213> Artificial Sequence


<220> 
<223> MYH6(614–629) peptide

<400> 89
Arg Ser Leu Lys Leu Met Ala Thr Leu Phe Ser Thr Tyr Ala Ser Ala 
1               5                   10                  15      
Asp Arg 
        

<210> 90
<211> 168
<212> PRT
<213> Homo sapiens


<220> 
<223> human Gremlin-2

<400> 90
Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu Val 
1               5                   10                  15      
Lys Val Ala Glu Ala Arg Lys Asn Arg Pro Ala Gly Ala Ile Pro Ser 
            20                  25                  30          
Pro Tyr Lys Asp Gly Ser Ser Asn Asn Ser Glu Arg Trp Gln His Gln 
        35                  40                  45              
Ile Lys Glu Val Leu Ala Ser Ser Gln Glu Ala Leu Val Val Thr Glu 
    50                  55                  60                  
Arg Lys Tyr Leu Lys Ser Asp Trp Cys Lys Thr Gln Pro Leu Arg Gln 
65                  70                  75                  80  
Thr Val Ser Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe 
                85                  90                  95      
Cys Tyr Gly Gln Cys Asn Ser Phe Tyr Ile Pro Arg His Val Lys Lys 
            100                 105                 110         
Glu Glu Glu Ser Phe Gln Ser Cys Ala Phe Cys Lys Pro Gln Arg Val 
        115                 120                 125             
Thr Ser Val Leu Val Glu Leu Glu Cys Pro Gly Leu Asp Pro Pro Phe 
    130                 135                 140                 
Arg Leu Lys Lys Ile Gln Lys Val Lys Gln Cys Arg Cys Met Ser Val 
145                 150                 155                 160 
Asn Leu Ser Asp Ser Asp Lys Gln 
                165             

<210> 91
<211> 276
<212> DNA
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 3-A1-3

<400> 91
tctggcaaca ctttcaccag ctactggatg cactgggtga agcagaggcc tggacaaggc     60

cttgagtgga ttggaatgat tcatcctaat agtggtaata cttattacaa tgagaagttc    120

aagagcaaga ccactctgac tgtagacaaa tcctccagca cagcctacat gcaactcagc    180

agcctgacat ctgaggactc tgcggtctat tactgtgcaa gatcgagggg cttatactac    240

ggtagtcttg actactgggg ccaaggcacc actctc                              276


<210> 92
<211> 92
<212> PRT
<213> Artificial Sequence


<220> 
<223> HC recombinant sequence of 3-A1-3

<400> 92
Ser Gly Asn Thr Phe Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg 
1               5                   10                  15      
Pro Gly Gln Gly Leu Glu Trp Ile Gly Met Ile His Pro Asn Ser Gly 
            20                  25                  30          
Asn Thr Tyr Tyr Asn Glu Lys Phe Lys Ser Lys Thr Thr Leu Thr Val 
        35                  40                  45              
Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser 
    50                  55                  60                  
Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Ser Arg Gly Leu Tyr Tyr 
65                  70                  75                  80  
Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
                85                  90          

<210> 93
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR2 LC recombinant sequence of 14-D10-2

<400> 93
Gly Ala Thr 
1           

<210> 94
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR3 HC recombinant sequence of 3-A1-3

<400> 94
Ala Arg Ser Arg Gly Leu Tyr Tyr Gly Ser Leu Asp Tyr 
1               5                   10              

<210> 95
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> CDR1 HC recombinant sequence of 8-H2-2

<400> 95
Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               

<210> 96
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> huGREM1_105-121

<400> 96
Glu Glu Gly Cys Asn Ser Arg Thr Ile Ile Asn Arg Phe Cys Tyr Gly 
1               5                   10                  15      
Gln 
    

<210> 97
<211> 17
<212> PRT
<213> Homo sapiens


<220> 
<223> huGREM2_84-100

<400> 97
Glu Glu Gly Cys Arg Ser Arg Thr Ile Leu Asn Arg Phe Cys Tyr Gly 
1               5                   10                  15      
Gln 
    

<210> 98
<211> 15
<212> PRT
<213> Homo sapiens


<220> 
<223> huGREM2_1-15

<400> 98
Met Phe Trp Lys Leu Ser Leu Ser Leu Phe Leu Val Ala Val Leu 
1               5                   10                  15  

