                         SEQUENCE LISTING

<110>  The Methodist Hospital System
 
<120>  PSMA-TARGETED IMMUNOTHERAPIES FOR CANCERS

<130>  10063-049WO1

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

cctgttcagc tgcagcagtc tggacctgaa ctggagaagc ctggcgcttc agtgaagatg      120

tcctgcaagg cttctggtta ctcattcact ggctacaacg taaactgggt gagacagaac      180

aatggaaaga gccttgagtg gattggaaat attgatcctc tccatggtgg tactacctac      240

aaccagaaat tcaaggccaa ggccacattg actgtagaca gatcctccag cacagcctac      300

ttgcagctca agaacctgac atctgaggac tctgcagtct attactgtgc aagatctagt      360

aggtttgact actggggcca aggcaccact ctcacagtct cctcaggtgg cggtggcagc      420

ggcggtggtg gttccggagg cggcggttct gacattgtga tgacccagtc tcacaaattc      480

atgtccacat cagtaggaga cagggtcaac atcacctgca aggccagtca ggatgtgggt      540

actgctgtag cctggtatca acaaaaacca gggcaatctc ctaaactact aatttactgg      600

gcatccaccc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagat      660

ttcactctca ccattagcaa tgtgcaatct gaagacttgg cagattattt ctgtcaccaa      720

tttaccagct atccattcac gttcggctcg gggacaagct tggaaatgaa acggaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgaca tctacatctg ggcgcccctg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  2
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Gly Tyr Asn Val Asn Trp Val Arg Gln Asn Asn Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asp Pro Leu His Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Lys Ala Lys Ala Thr Leu Thr Val Asp Arg Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Leu Gln Leu Lys Asn Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Ser Arg Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys His Gln 
225                 230                 235                 240 


Phe Thr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Ser Leu Glu Met 
                245                 250                 255     


Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  3
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

cctgtccaat tgcagcagcc tggggctgcg ctggtgaggc ctggagcttc agtgaggctg      120

tcctgcaagg cttctggata ctccttcacc tactactgga tgaactgggt gatgcagagg      180

cctggccaag gccttgagtg gattggcatg attcatcctt ccgatagtga aactcggtta      240

agtcagaagt tcagggacaa ggccacattg actgtagaca aatcttccag cacagtctac      300

atgcaactca acagcccgac atctgatgac tctgcagtct attactgtgc aagagatggt      360

aacttccctt actatgcact agactactgg ggtcaaggaa cctcggtcac cgtctcctca      420

ggtggcggtg gcagcggcgg tggtggttcc ggaggcggcg gttctgatgt tgtgctgacc      480

caagctccac tctccctgcc tgtcagtctt ggagatcaag cctccatctc ttgcagatct      540

agtcagagcc ttgaatacag taatggaaac acctatttac attggtacct gcagaagcca      600

ggccagtctc cagaactcct gatctacaca gtttccaacc gattttctgg ggtcccagac      660

aggttcagtg gcagtggatc agggacagat ttcacactca agattcacag agtggaggct      720

gaggatctgg gagtttattt ctgctctcaa agtacacatg ttcccacgtt cggagggggg      780

accaagctgg agataaaacg gaccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgacatct acatctgggc gcccctggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc                                      1470


<210>  4
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Tyr Tyr Trp Met Asn Trp Val Met Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu 
65                  70                  75                  80  


Ser Gln Lys Phe Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Val Tyr Met Gln Leu Asn Ser Pro Thr Ser Asp Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Leu Thr 
145                 150                 155                 160 


Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile 
        195                 200                 205             


Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile His Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  5
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

cctgtgaagc tgcaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc      120

acatgcactg tctcagggtt ctcattaacc gactatggtg tgagttggat tcgccagcct      180

ccaggaaagg gtctggagtg gctgggagta atatggagcg atggaaacac atactataat      240

tcacctctca aatccagact gagcatcaac aaggacaact ccaagagcca agttttctta      300

aaaatgaaca gtctgcaaac tgatgactca gccatgtact actgtgccag acataaggtc      360

tatactatgg actactgggg tcaaggaacc tcagtcaccg tctcctcagg tggcggtggc      420

agcggcggtg gtggttccgg aggcggcggt tctactgtgc tcacccagtc tccagcaatc      480

atgtctgcat ctccagggga aaaggtcacc atgacctgca gggccagctc aagtgtaagt      540

tccagttact tgcactggta ccagcagaag tcaagtgcct cccccaaact ctggatttat      600

agaacatcca acttggcttc tggagtccct gctcgcttca gtggcagtgg gtctgggacc      660

tcttactctc tcacaatcag cagtttggag gctgaagatg ctgccactta ttactgccag      720

cagtacagtg gttacccact cacgttcggt gctgggacca agctggagct gaaacggacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg acatctacat ctgggcgccc ctggccggga cttgtggggt ccttctcctg      960

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1020

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1080

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1140

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1200

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1260

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1320

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1380

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1440

cctcgc                                                                1446


<210>  6
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
        35                  40                  45              


Leu Thr Asp Tyr Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Ser Asp Gly Asn Thr Tyr Tyr Asn 
65                  70                  75                  80  


Ser Pro Leu Lys Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Ser Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Lys Val Tyr Thr Met Asp Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Thr Val Leu Thr Gln Ser Pro Ala Ile 
145                 150                 155                 160 


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser 
                165                 170                 175     


Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Ser Ser 
            180                 185                 190         


Ala Ser Pro Lys Leu Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly 
        195                 200                 205             


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
    210                 215                 220                 


Thr Ile Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
225                 230                 235                 240 


Gln Tyr Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
                245                 250                 255     


Leu Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  7
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

cctgtgaagc tgcagcagtc tggacctgaa ctggagaagc ctggcgcatc agtgaagata      120

tcctgcaagg cttcaggtta ctcattcact ggctacaacg tgaactgggt gaagcagagc      180

aatggaaaga gccttgagtg gattggaaat attgatcctt accatggtgg tactacctac      240

aaccagaaat tcgaggccaa ggccacattg actgtagaca aatcctccag cacagcctac      300

atgcagctca agagccttac atctgaggac tctgcagtct attattgtgc aagatctagt      360

agatttgact actggggcca aggcaccact ctcacagtct cctcaggtgg cggtggcagc      420

ggcggtggtg gttccggagg cggcggttct gacattgtga tgacccagtc tcacaaattc      480

atgtccacat cagtgggaga cagggtcaac atcacctgca aggccagtca ggatgtgggt      540

actgctgtag cctggtatca acagaaacca gggcaatctc ctaaatttct aatttactgg      600

gcatccaccc ggcacactgg agtccctgat cgcttcacag gcagtggatc tgggacagat      660

ttcactctca ccattagcaa tgtgcagtct gaagacttgg cagattattt ctgtcatcag      720

tataccagct atccattcac gttcggctcg gggacaaagt tggaaatgaa acggaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgaca tctacatctg ggcgcccctg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgc                                                                   1443


<210>  8
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Glu 
            20                  25                  30          


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Gly Tyr Asn Val Asn Trp Val Lys Gln Ser Asn Gly Lys Ser 
    50                  55                  60                  


Leu Glu Trp Ile Gly Asn Ile Asp Pro Tyr His Gly Gly Thr Thr Tyr 
65                  70                  75                  80  


Asn Gln Lys Phe Glu Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Ala Tyr Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ser Ser Arg Phe Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser His Lys Phe 
145                 150                 155                 160 


Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser 
                165                 170                 175     


Gln Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Ser Pro Lys Phe Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys His Gln 
225                 230                 235                 240 


Tyr Thr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Met 
                245                 250                 255     


Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  9
<211>  1467
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

cctgttaagc tgcagcagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc      120

acctgcgctg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggaag      180

tttccaggaa acaaactgga gtggatgggc tacataagct acagtggtag aactacctac      240

aatccatctc tcgaaagtcg aatctctatc actcgagaca catccaaaaa ccagttcttc      300

ctgcagttga attctgtgac tactgaggac acagccacat attactgtgc aagatgttac      360

tacggtagta gctcccgttg gtatggtatg gactactggg gtcgcggaac ctcagtcgcc      420

gtgtcctcag gtggcggtgg cagcggcggt ggtggttccg gaggcggcgg ttctattgtg      480

ctcacccagt ctccagcaat catgtctgca tctccagggg taaaggtcac catgacctgc      540

agggccagct caagtgtaga ttccagttac ttgcactggt accagcagaa gtcaggtgcc      600

tccccccaag tctggattta tagcacatcc aacttggctt ctggagtccc ggctcgcttc      660

agtggcagtg ggtctgggac ctcttactct ctcacaatca gtagtgtgga ggctgaagat      720

gctgccactt attactgcca gcagtacagt ggttatccac tgacgttcgg tggaggcacc      780

aagctggaaa tcaaacggac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      840

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      900

gtgcacacga gggggctgga cttcgcctgt gacatctaca tctgggcgcc cctggccggg      960

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1020

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1080

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgc                                         1467


<210>  10
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Lys Leu Gln Gln Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Lys Pro Ser Gln Ser Leu Ser Leu Thr Cys Ala Val Thr Gly Tyr Ser 
        35                  40                  45              


Ile Thr Ser Asp Tyr Ala Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn 
    50                  55                  60                  


Lys Leu Glu Trp Met Gly Tyr Ile Ser Tyr Ser Gly Arg Thr Thr Tyr 
65                  70                  75                  80  


Asn Pro Ser Leu Glu Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
                85                  90                  95      


Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala 
            100                 105                 110         


Thr Tyr Tyr Cys Ala Arg Cys Tyr Tyr Gly Ser Ser Ser Arg Trp Tyr 
        115                 120                 125             


Gly Met Asp Tyr Trp Gly Arg Gly Thr Ser Val Ala Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Val 
145                 150                 155                 160 


Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Val Lys Val 
                165                 170                 175     


Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asp Ser Ser Tyr Leu His 
            180                 185                 190         


Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Gln Val Trp Ile Tyr Ser 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro Leu Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  11
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11
gttcagctgc agcagtctgg acctgaactg gagaagcctg gcgcttcagt gaagatgtcc       60

tgcaaggctt ctggttactc attcactggc tacaacgtaa actgggtgag acagaacaat      120

ggaaagagcc ttgagtggat tggaaatatt gatcctctcc atggtggtac tacctacaac      180

cagaaattca aggccaaggc cacattgact gtagacagat cctccagcac agcctacttg      240

cagctcaaga acctgacatc tgaggactct gcagtctatt actgtgcaag atctagtagg      300

tttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  12
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 
            20                  25                  30          


Val Asn Trp Val Arg Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asp Pro Leu His Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
    50                  55                  60                  


Ala Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr Leu 
65                  70                  75                  80  


Gln Leu Lys Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Ser Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  13
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcaac       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acaaaaacca      120

gggcaatctc ctaaactact aatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcaatct      240

gaagacttgg cagattattt ctgtcaccaa tttaccagct atccattcac gttcggctcg      300

gggacaagct tggaaatgaa acgg                                             324


<210>  14
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys His Gln Phe Thr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Ser Leu Glu Met Lys Arg 
            100                 105             


<210>  15
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
gtccaattgc agcagcctgg ggctgcgctg gtgaggcctg gagcttcagt gaggctgtcc       60

tgcaaggctt ctggatactc cttcacctac tactggatga actgggtgat gcagaggcct      120

ggccaaggcc ttgagtggat tggcatgatt catccttccg atagtgaaac tcggttaagt      180

cagaagttca gggacaaggc cacattgact gtagacaaat cttccagcac agtctacatg      240

caactcaaca gcccgacatc tgatgactct gcagtctatt actgtgcaag agatggtaac      300

ttcccttact atgcactaga ctactggggt caaggaacct cggtcaccgt ctcctca         357


<210>  16
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Arg Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Tyr Tyr Trp 
            20                  25                  30          


Met Asn Trp Val Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Arg 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr Met 
65                  70                  75                  80  


Gln Leu Asn Ser Pro Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
gatgttgtgc tgacccaagc tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgaa tacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccagaa ctcctgatct acacagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatt      240

cacagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccc      300

acgttcggag gggggaccaa gctggagata aaacgg                                336


<210>  18
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Asp Val Val Leu Thr Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Glu Leu Leu Ile Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


His Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  19
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
gtgaagctgc aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcaca       60

tgcactgtct cagggttctc attaaccgac tatggtgtga gttggattcg ccagcctcca      120

ggaaagggtc tggagtggct gggagtaata tggagcgatg gaaacacata ctataattca      180

cctctcaaat ccagactgag catcaacaag gacaactcca agagccaagt tttcttaaaa      240

atgaacagtc tgcaaactga tgactcagcc atgtactact gtgccagaca taaggtctat      300

actatggact actggggtca aggaacctca gtcaccgtct cctca                      345


<210>  20
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly 
            20                  25                  30          


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
        35                  40                  45              


Val Ile Trp Ser Asp Gly Asn Thr Tyr Tyr Asn Ser Pro Leu Lys Ser 
    50                  55                  60                  


Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
65                  70                  75                  80  


Met Asn Ser Leu Gln Thr Asp Asp Ser Ala Met Tyr Tyr Cys Ala Arg 
                85                  90                  95      


His Lys Val Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  21
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21
actgtgctca cccagtctcc agcaatcatg tctgcatctc caggggaaaa ggtcaccatg       60

acctgcaggg ccagctcaag tgtaagttcc agttacttgc actggtacca gcagaagtca      120

agtgcctccc ccaaactctg gatttataga acatccaact tggcttctgg agtccctgct      180

cgcttcagtg gcagtgggtc tgggacctct tactctctca caatcagcag tttggaggct      240

gaagatgctg ccacttatta ctgccagcag tacagtggtt acccactcac gttcggtgct      300

gggaccaagc tggagctgaa acgg                                             324


<210>  22
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Thr Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu 
1               5                   10                  15      


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Ser Ser Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Ser Ala Ser Pro Lys Leu Trp Ile 
        35                  40                  45              


Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
            100                 105             


<210>  23
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
gtgaagctgc agcagtctgg acctgaactg gagaagcctg gcgcatcagt gaagatatcc       60

tgcaaggctt caggttactc attcactggc tacaacgtga actgggtgaa gcagagcaat      120

ggaaagagcc ttgagtggat tggaaatatt gatccttacc atggtggtac tacctacaac      180

cagaaattcg aggccaaggc cacattgact gtagacaaat cctccagcac agcctacatg      240

cagctcaaga gccttacatc tgaggactct gcagtctatt attgtgcaag atctagtaga      300

tttgactact ggggccaagg caccactctc acagtctcct ca                         342


<210>  24
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser 
1               5                   10                  15      


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 
            20                  25                  30          


Val Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile Gly 
        35                  40                  45              


Asn Ile Asp Pro Tyr His Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
    50                  55                  60                  


Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Ser Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  25
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtgggaga cagggtcaac       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120

gggcaatctc ctaaatttct aatttactgg gcatccaccc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttgg cagattattt ctgtcatcag tataccagct atccattcac gttcggctcg      300

gggacaaagt tggaaatgaa acgg                                             324


<210>  26
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys His Gln Tyr Thr Ser Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105             


<210>  27
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27
gttaagctgc agcagtcggg acctggcctg gtgaaacctt ctcagtctct gtccctcacc       60

tgcgctgtca ctggctactc aatcaccagt gattatgcct ggaactggat ccggaagttt      120

ccaggaaaca aactggagtg gatgggctac ataagctaca gtggtagaac tacctacaat      180

ccatctctcg aaagtcgaat ctctatcact cgagacacat ccaaaaacca gttcttcctg      240

cagttgaatt ctgtgactac tgaggacaca gccacatatt actgtgcaag atgttactac      300

ggtagtagct cccgttggta tggtatggac tactggggtc gcggaacctc agtcgccgtg      360

tcctca                                                                 366


<210>  28
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Val Lys Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Leu Thr Cys Ala Val Thr Gly Tyr Ser Ile Thr Ser Asp Tyr 
            20                  25                  30          


Ala Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Arg Thr Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Ser Ser Arg Trp Tyr Gly Met Asp Tyr Trp 
            100                 105                 110         


Gly Arg Gly Thr Ser Val Ala Val Ser Ser 
        115                 120         


<210>  29
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29
attgtgctca cccagtctcc agcaatcatg tctgcatctc caggggtaaa ggtcaccatg       60

acctgcaggg ccagctcaag tgtagattcc agttacttgc actggtacca gcagaagtca      120

ggtgcctccc cccaagtctg gatttatagc acatccaact tggcttctgg agtcccggct      180

cgcttcagtg gcagtgggtc tgggacctct tactctctca caatcagtag tgtggaggct      240

gaagatgctg ccacttatta ctgccagcag tacagtggtt atccactgac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  30
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Val 
1               5                   10                  15      


Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Asp Ser Ser Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser Pro Gln Val Trp Ile 
        35                  40                  45              


Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  31
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  32
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  33
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  34
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  35
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala 
1               5                   10                  15      


Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile 
            20                  25                  30          


Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser 
        35                  40                  45              


Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg 
    50                  55                  60                  


Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys 
65                  70                  75                  80  


Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg 
                85                  90                  95      


Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu 
            100                 105                 110         


Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val 
        115                 120                 125             


Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro 
    130                 135                 140                 


Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser 
145                 150                 155                 160 


Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg 
                165                 170                 175     


Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr 
            180                 185                 190         


Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro 
        195                 200                 205             


Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala 
    210                 215                 220                 


Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg 
225                 230                 235                 240 


Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu 
                245                 250                 255     


Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu 
            260                 265                 270         


Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp 
        275                 280                 285             


Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile 
    290                 295                 300                 


Glu Lys Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala 
305                 310                 315                 320 


Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp 
                325                 330                 335     


Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg 
            340                 345                 350         


Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu 
        355                 360                 365             


Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr 
    370                 375                 380                 


Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu 
385                 390                 395                 400 


Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe 
                405                 410                 415     


Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu 
            420                 425                 430         


His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser 
        435                 440                 445             


Ile Gln Glu 
    450     


<210>  36
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  38
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca tgcggctcga       60

cctgacatcg tgatgacaca gtctcacaag ttcatgtcca cctctgtggg cgacagggtg      120

aacatcacat gcaaggcctc ccaggatgtg ggcaccgcag tggcctggta tcagcagaag      180

cccggccaga gccctaagct gctgatctat tgggcctcca ccaggcacac aggcgtgcct      240

gaccgcttca caggcagcgg ctccggcacc gacttcaccc tgacaatctc taatgtgcag      300

agcgaggacc tggccgatta cttctgccac cagtttacca gctatccatt cacatttggc      360

tctggcacca gcctggagat gaagagagga ggaggaggca gcggcggagg aggctccggc      420

ggcggcggct ctgtgcagct gcagcagtcc ggaccagagc tggagaagcc aggagcctcc      480

gtgaagatgt cttgtaaggc ctccggctac tctttcacag gctataacgt gaattgggtg      540

cggcagaaca atggcaagag cctggagtgg atcggaaaca tcgacccact gcacggcggc      600

accacataca atcagaagtt taaggccaag gccaccctga cagtggatag aagctcctct      660

acagcctatc tgcagctgaa gaacctgacc agcgaggact ccgccgtgta ctattgtgcc      720

cggagcagcc ggtttgatta ctggggccag ggcaccacac tgaccgtgtc tagcaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgaca tctacatctg ggcgcccctg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgctag                                                                1446


<210>  39
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys His Gln Phe 
            100                 105                 110         


Thr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Ser Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 
                165                 170                 175     


Val Asn Trp Val Arg Gln Asn Asn Gly Lys Ser Leu Glu Trp Ile Gly 
            180                 185                 190         


Asn Ile Asp Pro Leu His Gly Gly Thr Thr Tyr Asn Gln Lys Phe Lys 
        195                 200                 205             


Ala Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Leu Lys Asn Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Ser Ser Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  40
<211>  1473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  40
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca tgcggctcga       60

cctgacgtgg tgctgaccca ggcaccactg agcctgcccg tgagcctggg cgatcaggcc      120

tccatctctt gcagaagctc ccagtctctg gagtacagca acggcaatac ctacctgcac      180

tggtatctgc agaagccagg ccagagcccc gagctgctga tctatacagt gtccaaccgg      240

ttctctggcg tgcctgaccg gttcagcggc tccggctctg gcaccgattt cacactgaag      300

atccacaggg tggaggcaga ggacctgggc gtgtacttct gcagccagtc cacccacgtg      360

cccacatttg gcggcggcac caagctggag atcaagaggg gaggaggagg ctctggagga      420

ggaggcagcg gcggcggcgg ctccgtgcag ctgcagcagc ctggcgccgc cctggtgcgg      480

ccaggagcca gcgtgagact gtcctgtaag gcctccggct attctttcac ctactattgg      540

atgaattggg tcatgcagag gccaggacag ggcctggagt ggatcggcat gatccaccct      600

tctgatagcg agacaaggct gagccagaag tttcgcgaca aggccaccct gacagtggat      660

aagtctagct ccaccgtgta catgcagctg aacagcccaa catccgacga ttctgccgtg      720

tactattgtg cccgggacgg caattttccc tactatgccc tggattattg gggccagggc      780

acctccgtga cagtgtctag caccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgacatct acatctgggc gcccctggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc tag                                  1473


<210>  41
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Leu Thr Gln Ala Pro Leu Ser Leu 
            20                  25                  30          


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
        35                  40                  45              


Ser Leu Glu Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile Tyr Thr Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile His Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Phe Cys Ser Gln Ser Thr His Val Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Arg 
145                 150                 155                 160 


Pro Gly Ala Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
                165                 170                 175     


Thr Tyr Tyr Trp Met Asn Trp Val Met Gln Arg Pro Gly Gln Gly Leu 
            180                 185                 190         


Glu Trp Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Ser 
        195                 200                 205             


Gln Lys Phe Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
    210                 215                 220                 


Thr Val Tyr Met Gln Leu Asn Ser Pro Thr Ser Asp Asp Ser Ala Val 
225                 230                 235                 240 


Tyr Tyr Cys Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490 


<210>  42
<211>  1449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca tgcggctcga       60

cctaccgtgc tgacacagtc ccctgccatc atgagcgcct ccccaggaga gaaggtgacc      120

atgacatgca gggccagcag cagcgtgagc agcagctacc tgcactggta tcagcagaag      180

agcagcgcca gccccaagct gtggatctac cggacctcca acctggcctc tggcgtgcct      240

gccagattct ctggcagcgg ctccggcacc tcttatagcc tgacaatctc tagcctggag      300

gcagaggacg cagcaaccta ctattgccag cagtactccg gctatccact gacctttggc      360

gccggcacaa agctggagct gaagagggga ggaggaggca gcggcggagg aggctccggc      420

ggcggcggct ctgtgaagct gcaggagtcc ggaccaggac tggtggcacc atcccagtct      480

ctgagcatca cctgtacagt gagcggcttc tccctgaccg attacggcgt gtcttggatc      540

aggcagccac ctggcaaggg cctggagtgg ctgggcgtga tctggtctga cggcaacaca      600

tactataata gccccctgaa gtctcgcctg agcatcaaca aggataattc caagtctcag      660

gtgtttctga agatgaatag cctgcagacc gacgattccg ccatgtacta ttgtgcccgg      720

cacaaggtgt acacaatgga ctattggggc cagggcacca gcgtgacagt gtcctctacc      780

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      840

ctgcgcccag aggcgtgccg gccagcggcg gggggcgcag tgcacacgag ggggctggac      900

ttcgcctgtg acatctacat ctgggcgccc ctggccggga cttgtggggt ccttctcctg      960

tcactggtta tcacccttta ctgcaaacgg ggcagaaaga aactcctgta tatattcaaa     1020

caaccattta tgagaccagt acaaactact caagaggaag atggctgtag ctgccgattt     1080

ccagaagaag aagaaggagg atgtgaactg agagtgaagt tcagcaggag cgcagacgcc     1140

cccgcgtaca agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1200

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1260

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1320

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1380

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1440

cctcgctag                                                             1449


<210>  43
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Thr Val Leu Thr Gln Ser Pro Ala Ile Met Ser 
            20                  25                  30          


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Ser Ser Ala Ser 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Ser Asp Gly Asn Thr Tyr Tyr Asn Ser Pro Leu Lys Ser 
        195                 200                 205             


Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Ser Ala Met Tyr Tyr Cys Ala Arg 
225                 230                 235                 240 


His Lys Val Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
                245                 250                 255     


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
            260                 265                 270         


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
        275                 280                 285             


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
    290                 295                 300                 


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
305                 310                 315                 320 


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  44
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca tgcggctcga       60

cctgacatcg tgatgacaca gtctcacaag ttcatgtcca cctctgtggg cgaccgggtg      120

aacatcacat gcaaggccag ccaggatgtg ggcaccgcag tggcctggta tcagcagaag      180

cccggccaga gccctaagtt tctgatctat tgggcctcca ccaggcacac aggcgtgcct      240

gaccgcttca caggcagcgg ctccggcacc gacttcaccc tgacaatctc caatgtgcag      300

tctgaggacc tggccgatta cttctgccac cagtacacct cctatccatt cacatttggc      360

tctggcacca agctggagat gaagagggga ggaggaggct ccggcggagg aggctctggc      420

ggcggcggca gcgtgaagct gcagcagtcc ggaccagagc tggagaagcc aggagccagc      480

gtgaagatca gctgtaaggc ctctggctac agcttcacag gctataacgt gaattgggtg      540

aagcagtcta acggcaagag cctggagtgg atcggcaata tcgaccccta ccacggcggc      600

accacatata accagaagtt tgaggccaag gccaccctga cagtggataa gagcagcagc      660

accgcctaca tgcagctgaa gtccctgacc tctgaggaca gcgccgtgta ctattgtgcc      720

cggagcagcc ggtttgatta ttggggccag ggcaccacac tgaccgtgtc tagcaccacg      780

acgccagcgc cgcgaccacc aacaccggcg cccaccatcg cgtcgcagcc cctgtccctg      840

cgcccagagg cgtgccggcc agcggcgggg ggcgcagtgc acacgagggg gctggacttc      900

gcctgtgaca tctacatctg ggcgcccctg gccgggactt gtggggtcct tctcctgtca      960

ctggttatca ccctttactg caaacggggc agaaagaaac tcctgtatat attcaaacaa     1020

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1080

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1140

gcgtacaagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1200

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1260

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1320

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1380

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1440

cgctag                                                                1446


<210>  45
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asp Val Gly Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Phe Leu Ile Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Asn Val Gln Ser Glu Asp Leu Ala Asp Tyr Phe Cys His Gln Tyr 
            100                 105                 110         


Thr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Met Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Val Lys Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser 
145                 150                 155                 160 


Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Asn 
                165                 170                 175     


Val Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile Gly 
            180                 185                 190         


Asn Ile Asp Pro Tyr His Gly Gly Thr Thr Tyr Asn Gln Lys Phe Glu 
        195                 200                 205             


Ala Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met 
    210                 215                 220                 


Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Ser Ser Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
            260                 265                 270         


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
        275                 280                 285             


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
    290                 295                 300                 


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
305                 310                 315                 320 


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  46
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca tgcggctcga       60

cctatcgtgc tgacccagag cccagccatc atgagcgcct ccccaggagt gaaggtgacc      120

atgacatgca gggccagctc ctctgtggac agctcctacc tgcactggta tcagcagaag      180

tctggcgcca gccctcaagt gtggatctac tctaccagca acctggcctc tggcgtgcca      240

gcacgcttct ccggctctgg cagcggcacc tcctattctc tgacaatctc tagcgtggag      300

gccgaggatg ccgccacata ctattgccag cagtactccg gctatcccct gacctttggc      360

ggcggcacaa agctggagat caagagggga ggaggaggca gcggcggagg aggctccggc      420

ggcggcggct ctgtgaagct gcagcagagc ggaccaggac tggtgaagcc tagccagtcc      480

ctgtctctga cctgtgccgt gacaggctac tccatcacct ctgactatgc ctggaactgg      540

atcagaaagt tccccggcaa taagctggag tggatgggct acatcagcta ttccggcaga      600

accacataca atcctagcct ggagtcccgg atctctatca ccagagacac aagcaagaac      660

cagttctttc tgcagctgaa cagcgtgacc acagaggata ccgccacata ctattgcgcc      720

aggtgttact atggctcctc tagccgctgg tacggcatgg attattgggg ccggggcaca      780

tccgtggccg tgtcctctac cacgacgcca gcgccgcgac caccaacacc ggcgcccacc      840

atcgcgtcgc agcccctgtc cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca      900

gtgcacacga gggggctgga cttcgcctgt gacatctaca tctgggcgcc cctggccggg      960

acttgtgggg tccttctcct gtcactggtt atcacccttt actgcaaacg gggcagaaag     1020

aaactcctgt atatattcaa acaaccattt atgagaccag tacaaactac tcaagaggaa     1080

gatggctgta gctgccgatt tccagaagaa gaagaaggag gatgtgaact gagagtgaag     1140

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     1200

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     1260

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     1320

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     1380

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     1440

cttcacatgc aggccctgcc ccctcgctag                                      1470


<210>  47
<211>  489
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser 
            20                  25                  30          


Ala Ser Pro Gly Val Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser 
        35                  40                  45              


Val Asp Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Ser Gly Ala Ser 
    50                  55                  60                  


Pro Gln Val Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Ser Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Gly Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Val Lys Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Leu Thr Cys Ala Val Thr Gly Tyr Ser Ile Thr Ser Asp Tyr 
                165                 170                 175     


Ala Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Trp Met 
            180                 185                 190         


Gly Tyr Ile Ser Tyr Ser Gly Arg Thr Thr Tyr Asn Pro Ser Leu Glu 
        195                 200                 205             


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
    210                 215                 220                 


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Cys Tyr Tyr Gly Ser Ser Ser Arg Trp Tyr Gly Met Asp Tyr Trp 
                245                 250                 255     


Gly Arg Gly Thr Ser Val Ala Val Ser Ser Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  48
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccg                                                                     63


<210>  49
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  50
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggactaagt tggaaataac aggtggcggt ggcagcggcg gtggtggttc cggaggcggc      360

ggttctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggtc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  51
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  52
<211>  207
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgatatcta catctgggcg cccctggccg ggacttgtgg ggtccttctc      180

ctgtcactgg ttatcaccct ttactgc                                          207


<210>  53
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  54
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  55
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55
gagtgaagtt cagcaggagc gcagacgccc ccgcgtacaa gcagggccag aaccagctct       60

ataacgagct caatctagga cgaagagagg agtacgatgt tttggacaag agacgtggcc      120

gggaccctga gatgggggga aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg      180

aactgcagaa agataagatg gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc      240

ggaggggcaa ggggcacgat ggcctttacc agggtctcag tacagccacc aaggacacct      300

acgacgccct tcacatgcag gccctgcccc ctcgc                                 335


<210>  56
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56
gagggcagag gcagcctgct gacatgtggc gacgttgaag agaatcctgg gccc             54


<210>  57
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57
atgaacctgg agggcggcgg ccgaggcgga gagttcggca tgagcgcggt gagctgcggc       60

aacgggaagc tccgccagtg gctgatcgac cagatcgaca gcggcaagta ccccgggctg      120

gtgtgggaga acgaggagaa gagcatcttc cgcatcccct ggaagcacgc gggcaagcag      180

gactacaacc gcgaggagga cgccgcgctc ttcaaggctt gggcactgtt taaaggaaag      240

ttccgagaag gcatcgacaa gccggaccct cccacctgga agacgcgcct gcggtgcgct      300

ttgaacaaga gcaatgactt tgaggaactg gttgagcgga gccagctgga catctcagac      360

ccgtacaaag tgtacaggat tgttcctgag ggagccaaaa aaggagccaa gcagctcacc      420

ttggaggacc cgcagatgtc catgagccac ccctacacca tgacaacgcc ttacccttcg      480

ctcccagccc agcaggttca caactacatg atgccacccc tcgaccgaag ctggagggac      540

tacgtcccgg atcagccaca cccggaaatc ccgtaccaat gtcccatgac gtttggaccc      600

cgcggccacc actggcaagg cccagcttgt gaaaatggtt gccaggtgac aggaaccttt      660

tatgcttgtg ccccacctga gtcccaggct cccggagtcc ccacagagcc aagcataagg      720

tctgccgaag ccttggcgtt ctcagactgc cggctgcaca tctgcctgta ctaccgggaa      780

atcctcgtga aggagctgac cacgtccagc cccgagggct gccggatctc ccatggacat      840

acgtatgacg ccagcaacct ggaccaggtc ctgttcccct acccagagga caatggccag      900

aggaaaaaca ttgagaagct gctgagccac ctggagaggg gcgtggtcct ctggatggcc      960

cccgacgggc tctatgcgaa aagactgtgc cagagcagga tctactggga cgggcccctg     1020

gcgctgtgca acgaccggcc caacaaactg gagagagacc agacctgcaa gctctttgac     1080

acacagcagt tcttgtcaga gctgcaagcg tttgctcacc acggccgctc cctgccaaga     1140

ttccaggtga ctctatgctt tggagaggag tttccagacc ctcagaggca aagaaagctc     1200

atcacagctc acgtagaacc tctgctagcc agacaactat attattttgc tcaacaaaac     1260

agtggacatt tcctgagggg ctacgattta ccagaacaca tcagcaatcc agaagattac     1320

cacagatcta tccgccattc ctctattcaa gaatga                               1356


<210>  58
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Met Asn Leu Glu Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala 
1               5                   10                  15      


Val Ser Cys Gly Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile 
            20                  25                  30          


Asp Ser Gly Lys Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser 
        35                  40                  45              


Ile Phe Arg Ile Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg 
    50                  55                  60                  


Glu Glu Asp Ala Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys 
65                  70                  75                  80  


Phe Arg Glu Gly Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg 
                85                  90                  95      


Leu Arg Cys Ala Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu 
            100                 105                 110         


Arg Ser Gln Leu Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val 
        115                 120                 125             


Pro Glu Gly Ala Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro 
    130                 135                 140                 


Gln Met Ser Met Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser 
145                 150                 155                 160 


Leu Pro Ala Gln Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg 
                165                 170                 175     


Ser Trp Arg Asp Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr 
            180                 185                 190         


Gln Cys Pro Met Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro 
        195                 200                 205             


Ala Cys Glu Asn Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala 
    210                 215                 220                 


Pro Pro Glu Ser Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg 
225                 230                 235                 240 


Ser Ala Glu Ala Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu 
                245                 250                 255     


Tyr Tyr Arg Glu Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu 
            260                 265                 270         


Gly Cys Arg Ile Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp 
        275                 280                 285             


Gln Val Leu Phe Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile 
    290                 295                 300                 


Glu Lys Leu Leu Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala 
305                 310                 315                 320 


Pro Asp Gly Leu Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp 
                325                 330                 335     


Asp Gly Pro Leu Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg 
            340                 345                 350         


Asp Gln Thr Cys Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu 
        355                 360                 365             


Gln Ala Phe Ala His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr 
    370                 375                 380                 


Leu Cys Phe Gly Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu 
385                 390                 395                 400 


Ile Thr Ala His Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe 
                405                 410                 415     


Ala Gln Gln Asn Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu 
            420                 425                 430         


His Ile Ser Asn Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser 
        435                 440                 445             


Ile Gln Glu 
    450     


<210>  59
<211>  2868
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg       60

ccggacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      120

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      180

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      240

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      300

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      360

ggggggacta agttggaaat aacaggtggc ggtggcagcg gcggtggtgg ttccggaggc      420

ggcggttctg aggtgaaact gcaggagtca ggacctggcc tggtggcgcc ctcacagagc      480

ctgtccgtca catgcactgt ctcaggggtc tcattacccg actatggtgt aagctggatt      540

cgccagcctc cacgaaaggg tctggagtgg ctgggagtaa tatggggtag tgaaaccaca      600

tactataatt cagctctcaa atccagactg accatcatca aggacaactc caagagccaa      660

gttttcttaa aaatgaacag tctgcaaact gatgacacag ccatttacta ctgtgccaaa      720

cattattact acggtggtag ctatgctatg gactactggg gtcaaggaac ctcagtcacc      780

gtctcctcaa ccacgacgcc agcgccgcga ccaccaacac cggcgcccac catcgcgtcg      840

cagcccctgt ccctgcgccc agaggcgtgc cggccagcgg cggggggcgc agtgcacacg      900

agggggctgg acttcgcctg tgatatctac atctgggcgc ccctggccgg gacttgtggg      960

gtccttctcc tgtcactggt tatcaccctt tactgcaaac ggggcagaaa gaaactcctg     1020

tatatattca aacaaccatt tatgagacca gtacaaacta ctcaagagga agatggctgt     1080

agctgccgat ttccagaaga agaagaagga ggatgtgaac tgagagtgaa gttcagcagg     1140

agcgcagacg cccccgcgta caagcagggc cagaaccagc tctataacga gctcaatcta     1200

ggacgaagag aggagtacga tgttttggac aagagacgtg gccgggaccc tgagatgggg     1260

ggaaagccga gaaggaagaa ccctcaggaa ggcctgtaca atgaactgca gaaagataag     1320

atggcggagg cctacagtga gattgggatg aaaggcgagc gccggagggg caaggggcac     1380

gatggccttt accagggtct cagtacagcc accaaggaca cctacgacgc ccttcacatg     1440

caggccctgc cccctcgcga gggcagaggc agcctgctga catgtggcga cgttgaagag     1500

aatcctgggc ccatgaacct ggagggcggc ggccgaggcg gagagttcgg catgagcgcg     1560

gtgagctgcg gcaacgggaa gctccgccag tggctgatcg accagatcga cagcggcaag     1620

taccccgggc tggtgtggga gaacgaggag aagagcatct tccgcatccc ctggaagcac     1680

gcgggcaagc aggactacaa ccgcgaggag gacgccgcgc tcttcaaggc ttgggcactg     1740

tttaaaggaa agttccgaga aggcatcgac aagccggacc ctcccacctg gaagacgcgc     1800

ctgcggtgcg ctttgaacaa gagcaatgac tttgaggaac tggttgagcg gagccagctg     1860

gacatctcag acccgtacaa agtgtacagg attgttcctg agggagccaa aaaaggagcc     1920

aagcagctca ccttggagga cccgcagatg tccatgagcc acccctacac catgacaacg     1980

ccttaccctt cgctcccagc ccagcaggtt cacaactaca tgatgccacc cctcgaccga     2040

agctggaggg actacgtccc ggatcagcca cacccggaaa tcccgtacca atgtcccatg     2100

acgtttggac cccgcggcca ccactggcaa ggcccagctt gtgaaaatgg ttgccaggtg     2160

acaggaacct tttatgcttg tgccccacct gagtcccagg ctcccggagt ccccacagag     2220

ccaagcataa ggtctgccga agccttggcg ttctcagact gccggctgca catctgcctg     2280

tactaccggg aaatcctcgt gaaggagctg accacgtcca gccccgaggg ctgccggatc     2340

tcccatggac atacgtatga cgccagcaac ctggaccagg tcctgttccc ctacccagag     2400

gacaatggcc agaggaaaaa cattgagaag ctgctgagcc acctggagag gggcgtggtc     2460

ctctggatgg cccccgacgg gctctatgcg aaaagactgt gccagagcag gatctactgg     2520

gacgggcccc tggcgctgtg caacgaccgg cccaacaaac tggagagaga ccagacctgc     2580

aagctctttg acacacagca gttcttgtca gagctgcaag cgtttgctca ccacggccgc     2640

tccctgccaa gattccaggt gactctatgc tttggagagg agtttccaga ccctcagagg     2700

caaagaaagc tcatcacagc tcacgtagaa cctctgctag ccagacaact atattatttt     2760

gctcaacaaa acagtggaca tttcctgagg ggctacgatt taccagaaca catcagcaat     2820

ccagaagatt accacagatc tatccgccat tcctctattc aagaatga                  2868


<210>  60
<211>  955
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr His Thr Ser Arg Leu His Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly 
            100                 105                 110         


Asn Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Lys Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser 
145                 150                 155                 160 


Leu Ser Val Thr Cys Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly 
                165                 170                 175     


Val Ser Trp Ile Arg Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly 
            180                 185                 190         


Val Ile Trp Gly Ser Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser 
        195                 200                 205             


Arg Leu Thr Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys 
    210                 215                 220                 


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


His Tyr Tyr Tyr Gly Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro 
            260                 265                 270         


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
        275                 280                 285             


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
    290                 295                 300                 


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
305                 310                 315                 320 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                325                 330                 335     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            340                 345                 350         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        355                 360                 365             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    370                 375                 380                 


Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
385                 390                 395                 400 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                405                 410                 415     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            420                 425                 430         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        435                 440                 445             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    450                 455                 460                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
465                 470                 475                 480 


Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
                485                 490                 495     


Asp Val Glu Glu Asn Pro Gly Pro Met Asn Leu Glu Gly Gly Gly Arg 
            500                 505                 510         


Gly Gly Glu Phe Gly Met Ser Ala Val Ser Cys Gly Asn Gly Lys Leu 
        515                 520                 525             


Arg Gln Trp Leu Ile Asp Gln Ile Asp Ser Gly Lys Tyr Pro Gly Leu 
    530                 535                 540                 


Val Trp Glu Asn Glu Glu Lys Ser Ile Phe Arg Ile Pro Trp Lys His 
545                 550                 555                 560 


Ala Gly Lys Gln Asp Tyr Asn Arg Glu Glu Asp Ala Ala Leu Phe Lys 
                565                 570                 575     


Ala Trp Ala Leu Phe Lys Gly Lys Phe Arg Glu Gly Ile Asp Lys Pro 
            580                 585                 590         


Asp Pro Pro Thr Trp Lys Thr Arg Leu Arg Cys Ala Leu Asn Lys Ser 
        595                 600                 605             


Asn Asp Phe Glu Glu Leu Val Glu Arg Ser Gln Leu Asp Ile Ser Asp 
    610                 615                 620                 


Pro Tyr Lys Val Tyr Arg Ile Val Pro Glu Gly Ala Lys Lys Gly Ala 
625                 630                 635                 640 


Lys Gln Leu Thr Leu Glu Asp Pro Gln Met Ser Met Ser His Pro Tyr 
                645                 650                 655     


Thr Met Thr Thr Pro Tyr Pro Ser Leu Pro Ala Gln Gln Val His Asn 
            660                 665                 670         


Tyr Met Met Pro Pro Leu Asp Arg Ser Trp Arg Asp Tyr Val Pro Asp 
        675                 680                 685             


Gln Pro His Pro Glu Ile Pro Tyr Gln Cys Pro Met Thr Phe Gly Pro 
    690                 695                 700                 


Arg Gly His His Trp Gln Gly Pro Ala Cys Glu Asn Gly Cys Gln Val 
705                 710                 715                 720 


Thr Gly Thr Phe Tyr Ala Cys Ala Pro Pro Glu Ser Gln Ala Pro Gly 
                725                 730                 735     


Val Pro Thr Glu Pro Ser Ile Arg Ser Ala Glu Ala Leu Ala Phe Ser 
            740                 745                 750         


Asp Cys Arg Leu His Ile Cys Leu Tyr Tyr Arg Glu Ile Leu Val Lys 
        755                 760                 765             


Glu Leu Thr Thr Ser Ser Pro Glu Gly Cys Arg Ile Ser His Gly His 
    770                 775                 780                 


Thr Tyr Asp Ala Ser Asn Leu Asp Gln Val Leu Phe Pro Tyr Pro Glu 
785                 790                 795                 800 


Asp Asn Gly Gln Arg Lys Asn Ile Glu Lys Leu Leu Ser His Leu Glu 
                805                 810                 815     


Arg Gly Val Val Leu Trp Met Ala Pro Asp Gly Leu Tyr Ala Lys Arg 
            820                 825                 830         


Leu Cys Gln Ser Arg Ile Tyr Trp Asp Gly Pro Leu Ala Leu Cys Asn 
        835                 840                 845             


Asp Arg Pro Asn Lys Leu Glu Arg Asp Gln Thr Cys Lys Leu Phe Asp 
    850                 855                 860                 


Thr Gln Gln Phe Leu Ser Glu Leu Gln Ala Phe Ala His His Gly Arg 
865                 870                 875                 880 


Ser Leu Pro Arg Phe Gln Val Thr Leu Cys Phe Gly Glu Glu Phe Pro 
                885                 890                 895     


Asp Pro Gln Arg Gln Arg Lys Leu Ile Thr Ala His Val Glu Pro Leu 
            900                 905                 910         


Leu Ala Arg Gln Leu Tyr Tyr Phe Ala Gln Gln Asn Ser Gly His Phe 
        915                 920                 925             


Leu Arg Gly Tyr Asp Leu Pro Glu His Ile Ser Asn Pro Glu Asp Tyr 
    930                 935                 940                 


His Arg Ser Ile Arg His Ser Ser Ile Gln Glu 
945                 950                 955 


<210>  61
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61
gtccagctcc aacagccggg tgctgcactg gttcggccag gagcttcagt gaggctgtcc       60

tgcaaggctt ctggatactc cttcacctac tactggatga actgggtgat gcagaggcct      120

ggccaaggcc ttgagtggat tggcatgatt catccttccg atagtgaaac tcggttaagt      180

cagaagttca gggacaaggc cacattgact gtagacaaat cttccagcac agtctacatg      240

caactcaaca gcccgacatc tgatgactct gcagtctatt actgtgcaag agatggtaac      300

ttcccttact atgcactaga ctactggggt caaggaacct cggtcaccgt ctcctcaggt      360

ggcggtggca gcggcggtgg tggttccgga ggcggcggtt ctgatgttgt gctgacccaa      420

gctccactct ccctgcctgt cagtcttgga gatcaagcct ccatctcttg cagatctagt      480

cagagccttg aatacagtaa tggaaacacc tatttacatt ggtacctgca gaagccaggc      540

cagtctccag aactcctgat ctacacagtt tccaaccgat tttctggggt cccagacagg      600

ttcagtggca gtggatcagg gacagatttc acactcaaga ttcacagagt ggaggctgag      660

gatctgggag tttatttctg ctctcaaagt acacatgttc ccacgttcgg aggggggacc      720

aagctggaga taaaacgg                                                    738


<210>  62
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val Arg Pro Gly Ala Ser 
1               5                   10                  15      


Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Tyr Tyr Trp 
            20                  25                  30          


Met Asn Trp Val Met Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu Ser Gln Lys Phe Arg 
    50                  55                  60                  


Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr Met 
65                  70                  75                  80  


Gln Leu Asn Ser Pro Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Val Val Leu Thr Gln Ala Pro Leu Ser 
    130                 135                 140                 


Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Glu Tyr Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu 
                165                 170                 175     


Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile Tyr Thr Val Ser Asn 
            180                 185                 190         


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Lys Ile His Arg Val Glu Ala Glu Asp Leu Gly Val 
    210                 215                 220                 


Tyr Phe Cys Ser Gln Ser Thr His Val Pro Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Arg 
                245     


<210>  63
<211>  2880
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca tgcggctcga       60

cctgtccagc tccaacagcc gggtgctgca ctggttcggc caggagcttc agtgaggctg      120

tcctgcaagg cttctggata ctccttcacc tactactgga tgaactgggt gatgcagagg      180

cctggccaag gccttgagtg gattggcatg attcatcctt ccgatagtga aactcggtta      240

agtcagaagt tcagggacaa ggccacattg actgtagaca aatcttccag cacagtctac      300

atgcaactca acagcccgac atctgatgac tctgcagtct attactgtgc aagagatggt      360

aacttccctt actatgcact agactactgg ggtcaaggaa cctcggtcac cgtctcctca      420

ggtggcggtg gcagcggcgg tggtggttcc ggaggcggcg gttctgatgt tgtgctgacc      480

caagctccac tctccctgcc tgtcagtctt ggagatcaag cctccatctc ttgcagatct      540

agtcagagcc ttgaatacag taatggaaac acctatttac attggtacct gcagaagcca      600

ggccagtctc cagaactcct gatctacaca gtttccaacc gattttctgg ggtcccagac      660

aggttcagtg gcagtggatc agggacagat ttcacactca agattcacag agtggaggct      720

gaggatctgg gagtttattt ctgctctcaa agtacacatg ttcccacgtt cggagggggg      780

accaagctgg agataaaacg gaccacgacg ccagcgccgc gaccaccaac accggcgccc      840

accatcgcgt cgcagcccct gtccctgcgc ccagaggcgt gccggccagc ggcggggggc      900

gcagtgcaca cgagggggct ggacttcgcc tgtgatatct acatctgggc gcccctggcc      960

gggacttgtg gggtccttct cctgtcactg gttatcaccc tttactgcaa acggggcaga     1020

aagaaactcc tgtatatatt caaacaacca tttatgagac cagtacaaac tactcaagag     1080

gaagatggct gtagctgccg atttccagaa gaagaagaag gaggatgtga actgagagtg     1140

aagttcagca ggagcgcaga cgcccccgcg tacaagcagg gccagaacca gctctataac     1200

gagctcaatc taggacgaag agaggagtac gatgttttgg acaagagacg tggccgggac     1260

cctgagatgg ggggaaagcc gagaaggaag aaccctcagg aaggcctgta caatgaactg     1320

cagaaagata agatggcgga ggcctacagt gagattggga tgaaaggcga gcgccggagg     1380

ggcaaggggc acgatggcct ttaccagggt ctcagtacag ccaccaagga cacctacgac     1440

gcccttcaca tgcaggccct gccccctcgc gagggcagag gcagcctgct gacatgtggc     1500

gacgttgaag agaatcctgg gcccatgaac ctggagggcg gcggccgagg cggagagttc     1560

ggcatgagcg cggtgagctg cggcaacggg aagctccgcc agtggctgat cgaccagatc     1620

gacagcggca agtaccccgg gctggtgtgg gagaacgagg agaagagcat cttccgcatc     1680

ccctggaagc acgcgggcaa gcaggactac aaccgcgagg aggacgccgc gctcttcaag     1740

gcttgggcac tgtttaaagg aaagttccga gaaggcatcg acaagccgga ccctcccacc     1800

tggaagacgc gcctgcggtg cgctttgaac aagagcaatg actttgagga actggttgag     1860

cggagccagc tggacatctc agacccgtac aaagtgtaca ggattgttcc tgagggagcc     1920

aaaaaaggag ccaagcagct caccttggag gacccgcaga tgtccatgag ccacccctac     1980

accatgacaa cgccttaccc ttcgctccca gcccagcagg ttcacaacta catgatgcca     2040

cccctcgacc gaagctggag ggactacgtc ccggatcagc cacacccgga aatcccgtac     2100

caatgtccca tgacgtttgg accccgcggc caccactggc aaggcccagc ttgtgaaaat     2160

ggttgccagg tgacaggaac cttttatgct tgtgccccac ctgagtccca ggctcccgga     2220

gtccccacag agccaagcat aaggtctgcc gaagccttgg cgttctcaga ctgccggctg     2280

cacatctgcc tgtactaccg ggaaatcctc gtgaaggagc tgaccacgtc cagccccgag     2340

ggctgccgga tctcccatgg acatacgtat gacgccagca acctggacca ggtcctgttc     2400

ccctacccag aggacaatgg ccagaggaaa aacattgaga agctgctgag ccacctggag     2460

aggggcgtgg tcctctggat ggcccccgac gggctctatg cgaaaagact gtgccagagc     2520

aggatctact gggacgggcc cctggcgctg tgcaacgacc ggcccaacaa actggagaga     2580

gaccagacct gcaagctctt tgacacacag cagttcttgt cagagctgca agcgtttgct     2640

caccacggcc gctccctgcc aagattccag gtgactctat gctttggaga ggagtttcca     2700

gaccctcaga ggcaaagaaa gctcatcaca gctcacgtag aacctctgct agccagacaa     2760

ctatattatt ttgctcaaca aaacagtgga catttcctga ggggctacga tttaccagaa     2820

cacatcagca atccagaaga ttaccacaga tctatccgcc attcctctat tcaagaatga     2880


<210>  64
<211>  959
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Val Gln Leu Gln Gln Pro Gly Ala Ala Leu Val 
            20                  25                  30          


Arg Pro Gly Ala Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Ser 
        35                  40                  45              


Phe Thr Tyr Tyr Trp Met Asn Trp Val Met Gln Arg Pro Gly Gln Gly 
    50                  55                  60                  


Leu Glu Trp Ile Gly Met Ile His Pro Ser Asp Ser Glu Thr Arg Leu 
65                  70                  75                  80  


Ser Gln Lys Phe Arg Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
                85                  90                  95      


Ser Thr Val Tyr Met Gln Leu Asn Ser Pro Thr Ser Asp Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Asp Gly Asn Phe Pro Tyr Tyr Ala Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Leu Thr 
145                 150                 155                 160 


Gln Ala Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile 
                165                 170                 175     


Ser Cys Arg Ser Ser Gln Ser Leu Glu Tyr Ser Asn Gly Asn Thr Tyr 
            180                 185                 190         


Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile 
        195                 200                 205             


Tyr Thr Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly 
    210                 215                 220                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile His Arg Val Glu Ala 
225                 230                 235                 240 


Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Thr Thr Pro Ala 
            260                 265                 270         


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
        275                 280                 285             


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
    290                 295                 300                 


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
305                 310                 315                 320 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
                325                 330                 335     


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
            340                 345                 350         


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
        355                 360                 365             


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
    370                 375                 380                 


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
                405                 410                 415     


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
            420                 425                 430         


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
        435                 440                 445             


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
    450                 455                 460                 


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
465                 470                 475                 480 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Glu Gly Arg Gly Ser Leu 
                485                 490                 495     


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asn Leu Glu 
            500                 505                 510         


Gly Gly Gly Arg Gly Gly Glu Phe Gly Met Ser Ala Val Ser Cys Gly 
        515                 520                 525             


Asn Gly Lys Leu Arg Gln Trp Leu Ile Asp Gln Ile Asp Ser Gly Lys 
    530                 535                 540                 


Tyr Pro Gly Leu Val Trp Glu Asn Glu Glu Lys Ser Ile Phe Arg Ile 
545                 550                 555                 560 


Pro Trp Lys His Ala Gly Lys Gln Asp Tyr Asn Arg Glu Glu Asp Ala 
                565                 570                 575     


Ala Leu Phe Lys Ala Trp Ala Leu Phe Lys Gly Lys Phe Arg Glu Gly 
            580                 585                 590         


Ile Asp Lys Pro Asp Pro Pro Thr Trp Lys Thr Arg Leu Arg Cys Ala 
        595                 600                 605             


Leu Asn Lys Ser Asn Asp Phe Glu Glu Leu Val Glu Arg Ser Gln Leu 
    610                 615                 620                 


Asp Ile Ser Asp Pro Tyr Lys Val Tyr Arg Ile Val Pro Glu Gly Ala 
625                 630                 635                 640 


Lys Lys Gly Ala Lys Gln Leu Thr Leu Glu Asp Pro Gln Met Ser Met 
                645                 650                 655     


Ser His Pro Tyr Thr Met Thr Thr Pro Tyr Pro Ser Leu Pro Ala Gln 
            660                 665                 670         


Gln Val His Asn Tyr Met Met Pro Pro Leu Asp Arg Ser Trp Arg Asp 
        675                 680                 685             


Tyr Val Pro Asp Gln Pro His Pro Glu Ile Pro Tyr Gln Cys Pro Met 
    690                 695                 700                 


Thr Phe Gly Pro Arg Gly His His Trp Gln Gly Pro Ala Cys Glu Asn 
705                 710                 715                 720 


Gly Cys Gln Val Thr Gly Thr Phe Tyr Ala Cys Ala Pro Pro Glu Ser 
                725                 730                 735     


Gln Ala Pro Gly Val Pro Thr Glu Pro Ser Ile Arg Ser Ala Glu Ala 
            740                 745                 750         


Leu Ala Phe Ser Asp Cys Arg Leu His Ile Cys Leu Tyr Tyr Arg Glu 
        755                 760                 765             


Ile Leu Val Lys Glu Leu Thr Thr Ser Ser Pro Glu Gly Cys Arg Ile 
    770                 775                 780                 


Ser His Gly His Thr Tyr Asp Ala Ser Asn Leu Asp Gln Val Leu Phe 
785                 790                 795                 800 


Pro Tyr Pro Glu Asp Asn Gly Gln Arg Lys Asn Ile Glu Lys Leu Leu 
                805                 810                 815     


Ser His Leu Glu Arg Gly Val Val Leu Trp Met Ala Pro Asp Gly Leu 
            820                 825                 830         


Tyr Ala Lys Arg Leu Cys Gln Ser Arg Ile Tyr Trp Asp Gly Pro Leu 
        835                 840                 845             


Ala Leu Cys Asn Asp Arg Pro Asn Lys Leu Glu Arg Asp Gln Thr Cys 
    850                 855                 860                 


Lys Leu Phe Asp Thr Gln Gln Phe Leu Ser Glu Leu Gln Ala Phe Ala 
865                 870                 875                 880 


His His Gly Arg Ser Leu Pro Arg Phe Gln Val Thr Leu Cys Phe Gly 
                885                 890                 895     


Glu Glu Phe Pro Asp Pro Gln Arg Gln Arg Lys Leu Ile Thr Ala His 
            900                 905                 910         


Val Glu Pro Leu Leu Ala Arg Gln Leu Tyr Tyr Phe Ala Gln Gln Asn 
        915                 920                 925             


Ser Gly His Phe Leu Arg Gly Tyr Asp Leu Pro Glu His Ile Ser Asn 
    930                 935                 940                 


Pro Glu Asp Tyr His Arg Ser Ile Arg His Ser Ser Ile Gln Glu 
945                 950                 955                 


