                         SEQUENCE LISTING

<110>  DUKE UNIVERSITY
       CHIBA-FALEK, Ornit
       KANTOR, Boris
 
<120>  COMPOSITIONS AND METHODS RELATING TO ALZHEIMER'S DISEASE

<130>  20-940-WO

<150>  US 63/104,343
<151>  2020-10-22

<150>  US 63/132,286
<151>  2020-12-30

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  6443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - ApoE gene

<400>  1
ggaacttgat gctcagagag gacaagtcat ttgcccaagg tcacacagct ggcaactggc       60

agagccagga ttcacgccct ggcaatttga ctccagaatc ctaaccttaa cccagaagca      120

cggcttcaag cccctggaaa ccacaatacc tgtggcagcc agggggaggt gctggaatct      180

catttcacat gtggggaggg ggctcccctg tgctcaaggt cacaaccaaa gaggaagctg      240

tgattaaaac ccaggtccca tttgcaaagc ctcgactttt agcaggtgca tcatactgtt      300

cccacccctc ccatcccact tctgtccagc cgcctagccc cactttcttt tttttctttt      360

tttgagacag tctccctctt gctgaggctg gagtgcagtg gcgagatctc ggctcactgt      420

aacctccgcc tcccgggttc aagcgattct cctgcctcag cctcccaagt agctaggatt      480

acaggcgccc gccaccacgc ctggctaact tttgtatttt tagtagagat ggggtttcac      540

catgttggcc aggctggtgt gaaactcctg accttaagtg attcgcccac tgtggcctcc      600

caaagtgctg ggattacagg cgtgagctac cgcccccagc ccctcccatc ccacttctgt      660

ccagccccct agccctactt tctttctggg atccaggagt ccagatcccc agccccctct      720

ccagattaca ttcatccagg cacaggaaag gacagggtca ggaaaggagg actctgggcg      780

gcagcctcca cattcccctt ccacgcttgg cccccagaat ggaggagggt gtcttgatta      840

ctgggcgagg tgtcctccct tcctggggac tgtggggggt ggtcaaaaga cctctatgcc      900

ccacctcctt cctccctctg ccctgctgtg cctggggcag ggggagaaca gcccacctcg      960

tgactggggg ctggcccagc ccgccctatc cctgggggag ggggcgggac agggggagcc     1020

ctataattgg acaagtctgg gatccttgag tcctactcag ccccagcgga ggtgaaggac     1080

gtccttcccc aggagccggt gagaagcgca gtcgggggca cggggatgag ctcaggggcc     1140

tctagaaaga gctgggaccc tgggaacccc tggcctccag gtagtctcag gagagctact     1200

cggggtcggg cttggggaga ggaggagcgg gggtgaggca agcagcaggg gactggacct     1260

gggaagggct gggcagcaga gacgacccga cccgctagaa ggtggggtgg ggagagcagc     1320

tggactggga tgtaagccat agcaggactc cacgagttgt cactatcatt tatcgagcac     1380

ctactgggtg tccccagtgt cctcagatct ccataactgg ggagccaggg gcagcgacac     1440

ggtagctagc cgtcgattgg agaactttaa aatgaggact gaattagctc ataaatggaa     1500

cacggcgctt aactgtgagg ttggagctta gaatgtgaag ggagaatgag gaatgcgaga     1560

ctgggactga gatggaaccg gcggtgggga gggggtgggg ggatggaatt tgaaccccgg     1620

gagaggaaga tggaattttc tatggaggcc gacctgggga tggggagata agagaagacc     1680

aggagggagt taaataggga atgggttggg ggcggcttgg taaatgtgct gggattaggc     1740

tgttgcagat aatgcaacaa ggcttggaag gctaacctgg ggtgaggccg ggttggggcc     1800

gggctggggg tgggaggagt cctcactggc ggttgattga cagtttctcc ttccccagac     1860

tggccaatca caggcaggaa gatgaaggtt ctgtgggctg cgttgctggt cacattcctg     1920

gcaggtatgg gggcggggct tgctcggttc cccccgctcc tccccctctc atcctcacct     1980

caacctcctg gccccattca ggcagaccct gggccccctc ttctgaggct tctgtgctgc     2040

ttcctggctc tgaacagcga tttgacgctc tctgggcctc ggtttccccc atccttgaga     2100

taggagttag aagttgtttt gttgttgttg tttgttgttg ttgttttgtt tttttgagat     2160

gaagtctcgc tctgtcgccc aggctggagt gcagtggcgg gatctcggct cactgcaagc     2220

tccgcctccc aggtccacgc cattctcctg cctcagcctc ccaagtagct gggactacag     2280

gcacatgcca ccacacccga ctaacttttt tgtattttca gtagagacgg ggtttcacca     2340

tgttggccag gctggtctgg aactcctgac ctcaggtgat ctgcccgttt cgatctccca     2400

aagtgctggg attacaggcg tgagccaccg cacctggctg ggagttagag gtttctaatg     2460

cattgcaggc agatagtgaa taccagacac ggggcagctg tgatctttat tctccatcac     2520

ccccacacag ccctgcctgg ggcacacaag gacactcaat acatgctttt ccgctgggcg     2580

cggtggctca cccctgtaat cccagcactt tgggaggcca aggtgggagg atcacttgag     2640

cccaggagtt caacaccagc ctgggcaaca tagtgagacc ctgtctctac taaaaataca     2700

aaaattagcc aggcatggtg ccacacacct gtgctctcag ctactcagga ggctgaggca     2760

ggaggatcgc ttgagcccag aaggtcaagg ttgcagtgaa ccatgttcag gccgctgcac     2820

tccagcctgg gtgacagagc aagaccctgt ttataaatac ataatgcttt ccaagtgatt     2880

aaaccgactc ccccctcacc ctgcccacca tggctccaaa gaagcatttg tggagcacct     2940

tctgtgtgcc cctaggtact agatgcctgg acggggtcag aaggaccctg acccaccttg     3000

aacttgttcc acacaggatg ccaggccaag gtggagcaag cggtggagac agagccggag     3060

cccgagctgc gccagcagac cgagtggcag agcggccagc gctgggaact ggcactgggt     3120

cgcttttggg attacctgcg ctgggtgcag acactgtctg agcaggtgca ggaggagctg     3180

ctcagctccc aggtcaccca ggaactgagg tgagtgtccc catcctggcc cttgaccctc     3240

ctggtgggcg gctatacctc cccaggtcca ggtttcattc tgcccctgtc gctaagtctt     3300

ggggggcctg ggtctctgct ggttctagct tcctcttccc atttctgact cctggcttta     3360

gctctctgga attctctctc tcagctttgt ctctctctct tcccttctga ctcagtctct     3420

cacactcgtc ctggctctgt ctctgtcctt ccctagctct tttatataga gacagagaga     3480

tggggtctca ctgtgttgcc caggctggtc ttgaacttct gggctcaagc gatcctcccg     3540

cctcggcctc ccaaagtgct gggattagag gcatgagcca ccttgcccgg cctcctagct     3600

ccttcttcgt ctctgcctct gccctctgca tctgctctct gcatctgtct ctgtctcctt     3660

ctctcggcct ctgccccgtt ccttctctcc ctcttgggtc tctctggctc atccccatct     3720

cgcccgcccc atcccagccc ttctccccgc ctcccactgt gcgacaccct cccgccctct     3780

cggccgcagg gcgctgatgg acgagaccat gaaggagttg aaggcctaca aatcggaact     3840

ggaggaacaa ctgaccccgg tggcggagga gacgcgggca cggctgtcca aggagctgca     3900

ggcggcgcag gcccggctgg gcgcggacat ggaggacgtg tgcggccgcc tggtgcagta     3960

ccgcggcgag gtgcaggcca tgctcggcca gagcaccgag gagctgcggg tgcgcctcgc     4020

ctcccacctg cgcaagctgc gtaagcggct cctccgcgat gccgatgacc tgcagaagcg     4080

cctggcagtg taccaggccg gggcccgcga gggcgccgag cgcggcctca gcgagcaggc     4140

ccagcagata cgcctgcagg ccgaggcctt ccaggcccgc ctcaagagct ggttcgagcc     4200

cctggtggaa gacatgcagc gccagtgggc cgggctggtg gagaaggtgc aggctgccgt     4260

gggcaccagc gccgcccctg tgcccagcga caatcactga acgccgaagc ctgcagccat     4320

gcgaccccac gccaccccgt gcctcctgcc tccgcgcagc ctgcagcggg agaccctgtc     4380

cccgccccag ccgtcctcct ggggtggacc ctagtttaat aaagattcac caagtttcac     4440

gcatctgctg gcctccccct gtgatttcct ctaagcccca gcctcagttt ctctttctgc     4500

ccacatactg gccacacaat tctcagcccc ctcctctcca tctgtgtctg tgtgtatctt     4560

tctctctgcc cttttttttt tttttagacg gagtctggct ctgtcaccca ggctagagtg     4620

cagtggcacg atcttggctc actgcaacct ctgcctcttg ggttcaagcg attctgctgc     4680

ctcagtagct gggattacag gctcacacca ccacacccgg ctaatttttg tatttttagt     4740

agagacgagc tttcaccatg ttggccaggc aggtctcaaa ctcctgacca agtgatccac     4800

ccgccggcct cccaaagtgc tgagattaca ggcctgagcc accatgcccg gcctctgccc     4860

ctctttcttt tttagggggc agggaaaggt ctcaccctgt cacccgccat cacagctcac     4920

tgcagcctcc acctcctgga ctcaagtgat aagtgatcct cccgcctcag cctttccagt     4980

agctgagact acaggcgcat accactagga ttaatttggg ggggggggtg gtgtgtgtgg     5040

agatggggtc tggctttgtt ggccaggctg atgtggaatt cctgggctca agcgatactc     5100

ccaccttggc ctcctgagta gctgagacta ctggctagca ccaccacacc cagcttttta     5160

ttattatttg tagagacaag gtctcaatat gttgcccagg ctagtctcaa acccctgggc     5220

tcaagagatc ctccgccatc ggcctcccaa agtgctggga ttccaggcat ggggctccga     5280

gcccggcctg cccaacttaa taatacttgt tcctcagagt tgcaactcca aatgacctga     5340

gattggtgcc tttattctaa gctattttca ttttttttct gctgtcatta ttctccccct     5400

tctctcctcc agtcttatct gatatctgcc tccttcccac ccaccctgca ccccatccca     5460

cccctctgtc tctccctgtt ctcctcagga gactctggct tcctgttttc ctccacttct     5520

atcttttatc tctccctcct acggtttctt ttctttctcc ccggcctgct tgtttctccc     5580

ccaaccccct tcatctggat ttcttcttct gccattcagt ttggtttgag ctctctgctt     5640

ctccggttcc ctctgagcta gctgtccctt cacccactgt gaactgggtt tccctgccca     5700

accctcattc tctttctttc tttctttttt tttttttttt tttttttttt tttttgagac     5760

agagtcttgc tctgttgccc agcctggagt gcagtggtgc aatcttggtt cactgcaacc     5820

tccacttccc agattcaagc aattctcctg cctcagcctc cagagtagct gggattacag     5880

gcgtgtccca ccacacccga ctaatttttg tatttttggt agagacaagg cttcggcatt     5940

gttggccagg caggtctcga actcctgacc tcaagtaatc tgcctgcctc accctcccaa     6000

agtgctggga ttacaggcat gagccacctc acccggacca tccctcattc tccatccttt     6060

cctccagttg tgatgtctac ccctcatgtt tcccaacaag cctactgggt gctgaatcca     6120

ggctgggaag agaagggagc ggctcttctg tcggagtctg caccaggccc atgctgagac     6180

gagagctggc gctcagagag gggaagcttg gatggaagcc caggagccgc cggcactctc     6240

ttctcctccc accccctcag ttctcagaga cggggaggag ggttcccacc aacgggggac     6300

aggctgagac ttgagcttgt atctcctggg ccagctgcaa catctgcttg tccctctgcc     6360

catcttggct cctgcacacc ctgaacttgg tgctttccct ggcactgctc tgatcaccca     6420

cgtggaggca gcacccctcc cct                                             6443


<210>  2
<211>  954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - APOEe2

<400>  2
atgaaggttc tgtgggctgc gttgctggtc acattcctgg caggatgcca ggccaaggtg       60

gagcaagcgg tggagacaga gccggagccc gagctgcgcc agcagaccga gtggcagagc      120

ggccagcgct gggaactggc actgggtcgc ttttgggatt acctgcgctg ggtgcagaca      180

ctgtctgagc aggtgcagga ggagctgctc agctcccagg tcacccagga actgagggcg      240

ctgatggacg agaccatgaa ggagttgaag gcctacaaat cggaactgga ggaacaactg      300

accccggtgg cggaggagac gcgggcacgg ctgtccaagg agctgcaggc ggcgcaggcc      360

cggctgggcg cggacatgga ggacgtgtgc ggccgcctgg tgcagtaccg cggcgaggtg      420

caggccatgc tcggccagag caccgaggag ctgcgggtgc gcctcgcctc ccacctgcgc      480

aagctgcgta agcggctcct ccgcgatgcc gatgacctgc agaagtgcct ggcagtgtac      540

caggccgggg cccgcgaggg cgccgagcgc ggcctcagcg ccatccgcga gcgcctgggg      600

cccctggtgg aacagggccg cgtgcgggcc gccactgtgg gctccctggc cggccagccg      660

ctacaggagc gggcccaggc ctggggcgag cggctgcgcg cgcggatgga ggagatgggc      720

agccggaccc gcgaccgcct ggacgaggtg aaggagcagg tggcggaggt gcgcgccaag      780

ctggaggagc aggcccagca gatacgcctg caggccgagg ccttccaggc ccgcctcaag      840

agctggttcg agcccctggt ggaagacatg cagcgccagt gggccgggct ggtggagaag      900

gtgcaggctg ccgtgggcac cagcgccgcc cctgtgccca gcgacaatca ctga            954


<210>  3
<211>  954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - APOEe3

<400>  3
atgaaggttc tgtgggctgc gttgctggtc acattcctgg caggatgcca ggccaaagtc       60

gaacaggctg tcgaaactga acccgaaccg gagctgcgcc agcagaccga gtggcagagc      120

ggccagcgct gggaactggc actgggtcgc ttttgggatt acctgcgctg ggtgcagaca      180

ctgtctgagc aggtgcagga ggagctgctc agctcccagg tcacccagga actgagggcg      240

ctgatggacg agaccatgaa ggagttgaag gcctacaaat cggaactgga ggaacaactg      300

accccggtgg cggaggagac gcgggcacgg ctgtccaagg agctgcaggc ggcgcaggcc      360

cggctgggcg cggacatgga ggacgtgtgc ggccgcctgg tgcagtaccg cggcgaggtg      420

caggccatgc tcggccagag caccgaggag ctgcgggtgc gcctcgcctc ccacctgcgc      480

aagcttcgta agcggctcct ccgcgatgcc gatgacctgc agaagcgcct ggcagtgtac      540

caggccgggg cccgcgaggg cgccgagcgc ggcctcagcg ccatccgcga gcgcctgggg      600

cccctggtgg aacagggccg cgtgcgggcc gccactgtgg gctccctggc cggccagccg      660

ctacaggagc gggcccaggc ctggggcgag cggctgcgcg cgcggatgga ggagatgggc      720

agccggaccc gcgaccgcct ggacgaggtg aaggagcagg tggcggaggt gcgcgccaag      780

ctggaggagc aggcccagca gatacgccta caggccgagg ccttccaggc ccgcctcaag      840

agctggttcg agcccctggt ggaagacatg cagcgccagt gggccgggct ggtggagaag      900

gtgcaggctg ccgtgggcac cagcgccgcc cctgtgccca gcgacaatca ctga            954


<210>  4
<211>  954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  APOEe4

<400>  4
atgaaggttc tgtgggctgc gttgctggtc acattcctgg caggatgcca ggccaaagtc       60

gaacaggctg tcgaaactga acccgaaccg gagctgcgcc agcagaccga gtggcagagc      120

ggccagcgct gggaactggc actgggtcgc ttttgggatt acctgcgctg ggtgcagaca      180

ctgtctgagc aggtgcagga ggagctgctc agctcccagg tcacccagga actgagggcg      240

ctgatggacg agaccatgaa ggagttgaag gcctacaaat cggaactgga ggaacaactg      300

accccggtgg cggaggagac gcgggcacgg ctgtccaagg agctgcaggc ggcgcaggcc      360

cggctgggcg cggacatgga ggacgtgcgc ggccgcctgg tgcagtaccg cggcgaggtg      420

caggccatgc tcggccagag caccgaggag ctgcgggtgc gcctcgcctc ccacctgcgc      480

aagcttcgta agcggctcct ccgcgatgcc gatgacctgc agaagcgcct ggcagtgtac      540

caggccgggg cccgcgaggg cgccgagcgc ggcctcagcg ccatccgcga gcgcctgggg      600

cccctggtgg aacagggccg cgtgcgggcc gccactgtgg gctccctggc cggccagccg      660

ctacaggagc gggcccaggc ctggggcgag cggctgcgcg cgcggatgga ggagatgggc      720

agccggaccc gcgaccgcct ggacgaggtg aaggagcagg tggcggaggt gcgcgccaag      780

ctggaggagc aggcccagca gatacgccta caggccgagg ccttccaggc ccgcctcaag      840

agctggttcg agcccctggt ggaagacatg cagcgccagt gggccgggct ggtggagaag      900

gtgcaggctg ccgtgggcac cagcgccgcc cctgtgccca gcgacaatca ctga            954


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA1 targeting promoter region of ApoE using SpCas9

<400>  5
gacaggggga gccctataat                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA2 targeting promoter region of ApoE using SpCas9

<400>  6
tcaggagagc tactcggggt                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA3 targeting promoter region of ApoE using SpCas9

<400>  7
actgggatgt aagccatagc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA4 targeting promoter region of ApoE using SpCas9

<400>  8
gttggagctt agaatgtgaa                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA1 targeting promoter region of ApoE using VRER 
       Cas9

<400>  9
gccctatccc tgggggaggg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA2 targeting promoter region of ApoE using VRER 
       Cas9

<400>  10
tcgggcttgg ggagaggagg                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA3 targeting promoter region of ApoE using VRER 
       Cas9

<400>  11
ctctccccac cccaccttct                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA4 targeting promoter region of ApoE using VRER 
       Cas9

<400>  12
tgtgaaggga gaatgaggaa                                                   20


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA targeting GFP ORF using SpCas9

<400>  13
ggcgaggagc tgttcaccg                                                    19


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA targeting GFP ORF using VRER-SpCas9

<400>  14
gccacaagtt cagcgtgtcc                                                   20


<210>  15
<211>  4107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - VRER

<400>  15
atggataaaa agtattctat tggtttagac atcggcacta attccgttgg atgggctgtc       60

ataaccgatg aatacaaagt accttcaaag aaatttaagg tgttggggaa cacagaccgt      120

cattcgatta aaaagaatct tatcggtgcc ctcctattcg atagtggcga aacggcagag      180

gcgactcgcc tgaaacgaac cgctcggaga aggtatacac gtcgcaagaa ccgaatatgt      240

tacttacaag aaatttttag caatgagatg gccaaagttg acgattcttt ctttcaccgt      300

ttggaagagt ccttccttgt cgaagaggac aagaaacatg aacggcaccc catctttgga      360

aacatagtag atgaggtggc atatcatgaa aagtacccaa cgatttatca cctcagaaaa      420

aagctagttg actcaactga taaagcggac ctgaggttaa tctacttggc tcttgcccat      480

atgataaagt tccgtgggca ctttctcatt gagggtgatc taaatccgga caactcggat      540

gtcgacaaac tgttcatcca gttagtacaa acctataatc agttgtttga agagaaccct      600

ataaatgcaa gtggcgtgga tgcgaaggct attcttagcg cccgcctctc taaatcccga      660

cggctagaaa acctgatcgc acaattaccc ggagagaaga aaaatgggtt gttcggtaac      720

cttatagcgc tctcactagg cctgacacca aattttaagt cgaacttcga cttagctgaa      780

gatgccaaat tgcagcttag taaggacacg tacgatgacg atctcgacaa tctactggca      840

caaattggag atcagtatgc ggacttattt ttggctgcca aaaaccttag cgatgcaatc      900

ctcctatctg acatactgag agttaatact gagattacca aggcgccgtt atccgcttca      960

atgatcaaaa ggtacgatga acatcaccaa gacttgacac ttctcaaggc cctagtccgt     1020

cagcaactgc ctgagaaata taaggaaata ttctttgatc agtcgaaaaa cgggtacgca     1080

ggttatattg acggcggagc gagtcaagag gaattctaca agtttatcaa acccatatta     1140

gagaagatgg atgggacgga agagttgctt gtaaaactca atcgcgaaga tctactgcga     1200

aagcagcgga ctttcgacaa cggtagcatt ccacatcaaa tccacttagg cgaattgcat     1260

gctatactta gaaggcagga ggatttttat ccgttcctca aagacaatcg tgaaaagatt     1320

gagaaaatcc taacctttcg cataccttac tatgtgggac ccctggcccg agggaactct     1380

cggttcgcat ggatgacaag aaagtccgaa gaaacgatta ctccatggaa ttttgaggaa     1440

gttgtcgata aaggtgcgtc agctcaatcg ttcatcgaga ggatgaccaa ctttgacaag     1500

aatttaccga acgaaaaagt attgcctaag cacagtttac tttacgagta tttcacagtg     1560

tacaatgaac tcacgaaagt taagtatgtc actgagggca tgcgtaaacc cgcctttcta     1620

agcggagaac agaagaaagc aatagtagat ctgttattca agaccaaccg caaagtgaca     1680

gttaagcaat tgaaagagga ctactttaag aaaattgaat gcttcgattc tgtcgagatc     1740

tccggggtag aagatcgatt taatgcgtca cttggtacgt atcatgacct cctaaagata     1800

attaaagata aggacttcct ggataacgaa gagaatgaag atatcttaga agatatagtg     1860

ttgactctta ccctctttga agatcgggaa atgattgagg aaagactaaa aacatacgct     1920

cacctgttcg acgataaggt tatgaaacag ttaaagaggc gtcgctatac gggctgggga     1980

cgattgtcgc ggaaacttat caacgggata agagacaagc aaagtggtaa aactattctc     2040

gattttctaa agagcgacgg cttcgccaat aggaacttta tgcagctgat ccatgatgac     2100

tctttaacct tcaaagagga tatacaaaag gcacaggttt ccggacaagg ggactcattg     2160

cacgaacata ttgcgaatct tgctggttcg ccagccatca aaaagggcat actccagaca     2220

gtcaaagtag tggatgagct agttaaggtc atgggacgtc acaaaccgga aaacattgta     2280

atcgagatgg cacgcgaaaa tcaaacgact cagaaggggc aaaaaaacag tcgagagcgg     2340

atgaagagaa tagaagaggg tattaaagaa ctgggcagcc agatcttaaa ggagcatcct     2400

gtggaaaata cccaattgca gaacgagaaa ctttacctct attacctaca aaatggaagg     2460

gacatgtatg ttgatcagga actggacata aaccgtttat ctgattacga cgtcgatcac     2520

attgtacccc aatccttttt gaaggacgat tcaatcgaca ataaagtgct tacacgctcg     2580

gataagaacc gagggaaaag tgacaatgtt ccaagcgagg aagtcgtaaa gaaaatgaag     2640

aactattggc ggcagctcct aaatgcgaaa ctgataacgc aaagaaagtt cgataactta     2700

actaaagctg agaggggtgg cttgtctgaa cttgacaagg ccggatttat taaacgtcag     2760

ctcgtggaaa cccgccaaat cacaaagcat gttgcacaga tactagattc ccgaatgaat     2820

acgaaatacg acgagaacga taagctgatt cgggaagtca aagtaatcac tttaaagtca     2880

aaattggtgt cggacttcag aaaggatttt caattctata aagttaggga gataaataac     2940

taccaccatg cgcacgacgc ttatcttaat gccgtcgtag ggaccgcact cattaagaaa     3000

tacccgaagc tagaaagtga gtttgtgtat ggtgattaca aagtttatga cgtccgtaag     3060

atgatcgcga aaagcgaaca ggagataggc aaggctacag ccaaatactt cttttattct     3120

aacattatga atttctttaa gacggaaatc actctggcaa acggagagat acgcaaacga     3180

cctttaattg aaaccaatgg ggagacaggt gaaatcgtat gggataaggg ccgggacttc     3240

gcgacggtga gaaaagtttt gtccatgccc caagtcaaca tagtaaagaa aactgaggtg     3300

cagaccggag ggttttcaaa ggaatcgatt cttccaaaaa ggaatagtga taagctcatc     3360

gctcgtaaaa aggactggga cccgaaaaag tacggtggct tcgtgagccc tacagttgcc     3420

tattctgtcc tagtagtggc aaaagttgag aagggaaaat ccaagaaact gaagtcagtc     3480

aaagaattat tggggataac gattatggag cgctcgtctt ttgaaaagaa ccccatcgac     3540

ttccttgagg cgaaaggtta caaggaagta aaaaaggatc tcataattaa actaccaaag     3600

tatagtctgt ttgagttaga aaatggccga aaacggatgt tggctagcgc cagagagctt     3660

caaaagggga acgaactcgc actaccgtct aaatacgtga atttcctgta tttagcgtcc     3720

cattacgaga agttgaaagg ttcacctgaa gataacgaac agaagcaact ttttgttgag     3780

cagcacaaac attatctcga cgaaatcata gagcaaattt cggaattcag taagagagtc     3840

atcctagctg atgccaatct ggacaaagta ttaagcgcat acaacaagca cagggataaa     3900

cccatacgtg agcaggcgga aaatattatc catttgttta ctcttaccaa cctcggcgct     3960

ccagccgcat tcaagtattt tgacacaacg atagatcgca aagagtacag atctaccaag     4020

gaggtgctag acgcgacact gattcaccaa tccatcacgg gattatatga aactcggata     4080

gatttgtcac agcttggggg tgactga                                         4107


<210>  16
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  16

Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  17
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - DNMT3A

<400>  17

Pro Ser Arg Leu Gln Met Phe Phe Ala Asn Asn His Asp Gln Glu Phe 
1               5                   10                  15      


Asp Pro Pro Lys Val Tyr Pro Pro Val Pro Ala Glu Lys Arg Lys Pro 
            20                  25                  30          


Ile Arg Val Leu Ser Leu Phe Asp Gly Ile Ala Thr Gly Leu Leu Val 
        35                  40                  45              


Leu Lys Asp Leu Gly Ile Gln Val Asp Arg Tyr Ile Ala Ser Glu Val 
    50                  55                  60                  


Cys Glu Asp Ser Ile Thr Val Gly Met Val Arg His Gln Gly Lys Ile 
65                  70                  75                  80  


Met Tyr Val Gly Asp Val Arg Ser Val Thr Gln Lys His Ile Gln Glu 
                85                  90                  95      


Trp Gly Pro Phe Asp Leu Val Ile Gly Gly Ser Pro Cys Asn Asp Leu 
            100                 105                 110         


Ser Ile Val Asn Pro Ala Arg Lys Gly Leu Tyr Glu Gly Thr Gly Arg 
        115                 120                 125             


Leu Phe Phe Glu Phe Tyr Arg Leu Leu His Asp Ala Arg Pro Lys Glu 
    130                 135                 140                 


Gly Asp Asp Arg Pro Phe Phe Trp Leu Phe Glu Asn Val Val Ala Met 
145                 150                 155                 160 


Gly Val Ser Asp Lys Arg Asp Ile Ser Arg Phe Leu Glu Ser Asn Pro 
                165                 170                 175     


Val Met Ile Asp Ala Lys Glu Val Ser Ala Ala His Arg Ala Arg Tyr 
            180                 185                 190         


Phe Trp Gly Asn Leu Pro Gly Met Asn Arg Pro Leu Ala Ser Thr Val 
        195                 200                 205             


Asn Asp Lys Leu Glu Leu Gln Glu Cys Leu Glu His Gly Arg Ile Ala 
    210                 215                 220                 


Lys Phe Ser Lys Val Arg Thr Ile Thr Thr Arg Ser Asn Ser Ile Lys 
225                 230                 235                 240 


Gln Gly Lys Asp Gln His Phe Pro Val Phe Met Asn Glu Lys Glu Asp 
                245                 250                 255     


Ile Leu Trp Cys Thr Glu Met Glu Arg Val Phe Gly Phe Pro Val His 
            260                 265                 270         


Tyr Thr Asp Val Ser Asn Met Ser Arg Leu Ala Arg Gln Arg Leu Leu 
        275                 280                 285             


Gly Arg Ser Trp Ser Val Pro Val Ile Arg His Leu Phe Ala Pro Leu 
    290                 295                 300                 


Lys Glu Tyr Phe Ala Cys Val 
305                 310     


<210>  18
<211>  933
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - DNMT3A

<400>  18

Cys Cys Cys Thr Cys Cys Cys Gly Gly Cys Thr Cys Cys Ala Gly Ala 
1               5                   10                  15      


Thr Gly Thr Thr Cys Thr Thr Cys Gly Cys Thr Ala Ala Thr Ala Ala 
            20                  25                  30          


Cys Cys Ala Cys Gly Ala Cys Cys Ala Gly Gly Ala Ala Thr Thr Thr 
        35                  40                  45              


Gly Ala Cys Cys Cys Thr Cys Cys Ala Ala Ala Gly Gly Thr Thr Thr 
    50                  55                  60                  


Ala Cys Cys Cys Ala Cys Cys Thr Gly Thr Cys Cys Cys Ala Gly Cys 
65                  70                  75                  80  


Thr Gly Ala Gly Ala Ala Gly Ala Gly Gly Ala Ala Gly Cys Cys Cys 
                85                  90                  95      


Ala Thr Cys Cys Gly Gly Gly Thr Gly Cys Thr Gly Thr Cys Thr Cys 
            100                 105                 110         


Thr Cys Thr Thr Thr Gly Ala Thr Gly Gly Ala Ala Thr Cys Gly Cys 
        115                 120                 125             


Thr Ala Cys Ala Gly Gly Gly Cys Thr Cys Cys Thr Gly Gly Thr Gly 
    130                 135                 140                 


Cys Thr Gly Ala Ala Gly Gly Ala Cys Thr Thr Gly Gly Gly Cys Ala 
145                 150                 155                 160 


Thr Thr Cys Ala Gly Gly Thr Gly Gly Ala Cys Cys Gly Cys Thr Ala 
                165                 170                 175     


Cys Ala Thr Thr Gly Cys Cys Thr Cys Gly Gly Ala Gly Gly Thr Gly 
            180                 185                 190         


Thr Gly Thr Gly Ala Gly Gly Ala Cys Thr Cys Cys Ala Thr Cys Ala 
        195                 200                 205             


Cys Gly Gly Thr Gly Gly Gly Cys Ala Thr Gly Gly Thr Gly Cys Gly 
    210                 215                 220                 


Gly Cys Ala Cys Cys Ala Gly Gly Gly Gly Ala Ala Gly Ala Thr Cys 
225                 230                 235                 240 


Ala Thr Gly Thr Ala Cys Gly Thr Cys Gly Gly Gly Gly Ala Cys Gly 
                245                 250                 255     


Thr Cys Cys Gly Cys Ala Gly Cys Gly Thr Cys Ala Cys Ala Cys Ala 
            260                 265                 270         


Gly Ala Ala Gly Cys Ala Thr Ala Thr Cys Cys Ala Gly Gly Ala Gly 
        275                 280                 285             


Thr Gly Gly Gly Gly Cys Cys Cys Ala Thr Thr Cys Gly Ala Thr Cys 
    290                 295                 300                 


Thr Gly Gly Thr Gly Ala Thr Thr Gly Gly Gly Gly Gly Cys Ala Gly 
305                 310                 315                 320 


Thr Cys Cys Cys Thr Gly Cys Ala Ala Thr Gly Ala Cys Cys Thr Cys 
                325                 330                 335     


Thr Cys Cys Ala Thr Cys Gly Thr Cys Ala Ala Cys Cys Cys Thr Gly 
            340                 345                 350         


Cys Thr Cys Gly Cys Ala Ala Gly Gly Gly Cys Cys Thr Cys Thr Ala 
        355                 360                 365             


Cys Gly Ala Gly Gly Gly Cys Ala Cys Thr Gly Gly Cys Cys Gly Gly 
    370                 375                 380                 


Cys Thr Cys Thr Thr Cys Thr Thr Thr Gly Ala Gly Thr Thr Cys Thr 
385                 390                 395                 400 


Ala Cys Cys Gly Cys Cys Thr Cys Cys Thr Gly Cys Ala Thr Gly Ala 
                405                 410                 415     


Thr Gly Cys Gly Cys Gly Gly Cys Cys Cys Ala Ala Gly Gly Ala Gly 
            420                 425                 430         


Gly Gly Ala Gly Ala Thr Gly Ala Thr Cys Gly Cys Cys Cys Cys Thr 
        435                 440                 445             


Thr Cys Thr Thr Cys Thr Gly Gly Cys Thr Cys Thr Thr Thr Gly Ala 
    450                 455                 460                 


Gly Ala Ala Thr Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Gly 
465                 470                 475                 480 


Gly Gly Cys Gly Thr Thr Ala Gly Thr Gly Ala Cys Ala Ala Gly Ala 
                485                 490                 495     


Gly Gly Gly Ala Cys Ala Thr Cys Thr Cys Gly Cys Gly Ala Thr Thr 
            500                 505                 510         


Thr Cys Thr Cys Gly Ala Gly Thr Cys Cys Ala Ala Cys Cys Cys Thr 
        515                 520                 525             


Gly Thr Gly Ala Thr Gly Ala Thr Thr Gly Ala Thr Gly Cys Cys Ala 
    530                 535                 540                 


Ala Ala Gly Ala Ala Gly Thr Gly Thr Cys Ala Gly Cys Thr Gly Cys 
545                 550                 555                 560 


Ala Cys Ala Cys Ala Gly Gly Gly Cys Cys Cys Gly Cys Thr Ala Cys 
                565                 570                 575     


Thr Thr Cys Thr Gly Gly Gly Gly Thr Ala Ala Cys Cys Thr Thr Cys 
            580                 585                 590         


Cys Cys Gly Gly Thr Ala Thr Gly Ala Ala Cys Ala Gly Gly Cys Cys 
        595                 600                 605             


Gly Thr Thr Gly Gly Cys Ala Thr Cys Cys Ala Cys Thr Gly Thr Gly 
    610                 615                 620                 


Ala Ala Thr Gly Ala Thr Ala Ala Gly Cys Thr Gly Gly Ala Gly Cys 
625                 630                 635                 640 


Thr Gly Cys Ala Gly Gly Ala Gly Thr Gly Thr Cys Thr Gly Gly Ala 
                645                 650                 655     


Gly Cys Ala Thr Gly Gly Cys Ala Gly Gly Ala Thr Ala Gly Cys Cys 
            660                 665                 670         


Ala Ala Gly Thr Thr Cys Ala Gly Cys Ala Ala Ala Gly Thr Gly Ala 
        675                 680                 685             


Gly Gly Ala Cys Cys Ala Thr Thr Ala Cys Thr Ala Cys Gly Ala Gly 
    690                 695                 700                 


Gly Thr Cys Ala Ala Ala Cys Thr Cys Cys Ala Thr Ala Ala Ala Gly 
705                 710                 715                 720 


Cys Ala Gly Gly Gly Cys Ala Ala Ala Gly Ala Cys Cys Ala Gly Cys 
                725                 730                 735     


Ala Thr Thr Thr Thr Cys Cys Thr Gly Thr Gly Thr Thr Cys Ala Thr 
            740                 745                 750         


Gly Ala Ala Thr Gly Ala Gly Ala Ala Ala Gly Ala Gly Gly Ala Cys 
        755                 760                 765             


Ala Thr Cys Thr Thr Ala Thr Gly Gly Thr Gly Cys Ala Cys Thr Gly 
    770                 775                 780                 


Ala Ala Ala Thr Gly Gly Ala Ala Ala Gly Gly Gly Thr Ala Thr Thr 
785                 790                 795                 800 


Thr Gly Gly Thr Thr Thr Cys Cys Cys Ala Gly Thr Cys Cys Ala Cys 
                805                 810                 815     


Thr Ala Thr Ala Cys Thr Gly Ala Cys Gly Thr Gly Thr Cys Cys Ala 
            820                 825                 830         


Ala Cys Ala Thr Gly Ala Gly Cys Cys Gly Cys Thr Thr Gly Gly Cys 
        835                 840                 845             


Gly Ala Gly Gly Cys Ala Gly Ala Gly Ala Cys Thr Gly Cys Thr Gly 
    850                 855                 860                 


Gly Gly Cys Cys Gly Gly Thr Cys Ala Thr Gly Gly Ala Gly Cys Gly 
865                 870                 875                 880 


Thr Gly Cys Cys Ala Gly Thr Cys Ala Thr Cys Cys Gly Cys Cys Ala 
                885                 890                 895     


Cys Cys Thr Cys Thr Thr Cys Gly Cys Thr Cys Cys Gly Cys Thr Gly 
            900                 905                 910         


Ala Ala Gly Gly Ala Gly Thr Ala Thr Thr Thr Thr Gly Cys Gly Thr 
        915                 920                 925             


Gly Thr Gly Thr Gly 
    930             


<210>  19
<211>  1702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - dCas9-DNMT3A fusion protein

<400>  19

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Lys 
    1355                 1360                 1365             


Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1370                 1375                 1380             


Leu Glu  Gly Gly Gly Gly Ser  Gly Ser Pro Ser Arg  Leu Gln Met 
    1385                 1390                 1395             


Phe Phe  Ala Asn Asn His Asp  Gln Glu Phe Asp Pro  Pro Lys Val 
    1400                 1405                 1410             


Tyr Pro  Pro Val Pro Ala Glu  Lys Arg Lys Pro Ile  Arg Val Leu 
    1415                 1420                 1425             


Ser Leu  Phe Asp Gly Ile Ala  Thr Gly Leu Leu Val  Leu Lys Asp 
    1430                 1435                 1440             


Leu Gly  Ile Gln Val Asp Arg  Tyr Ile Ala Ser Glu  Val Cys Glu 
    1445                 1450                 1455             


Asp Ser  Ile Thr Val Gly Met  Val Arg His Gln Gly  Lys Ile Met 
    1460                 1465                 1470             


Tyr Val  Gly Asp Val Arg Ser  Val Thr Gln Lys His  Ile Gln Glu 
    1475                 1480                 1485             


Trp Gly  Pro Phe Asp Leu Val  Ile Gly Gly Ser Pro  Cys Asn Asp 
    1490                 1495                 1500             


Leu Ser  Ile Val Asn Pro Ala  Arg Lys Gly Leu Tyr  Glu Gly Thr 
    1505                 1510                 1515             


Gly Arg  Leu Phe Phe Glu Phe  Tyr Arg Leu Leu His  Asp Ala Arg 
    1520                 1525                 1530             


Pro Lys  Glu Gly Asp Asp Arg  Pro Phe Phe Trp Leu  Phe Glu Asn 
    1535                 1540                 1545             


Val Val  Ala Met Gly Val Ser  Asp Lys Arg Asp Ile  Ser Arg Phe 
    1550                 1555                 1560             


Leu Glu  Ser Asn Pro Val Met  Ile Asp Ala Lys Glu  Val Ser Ala 
    1565                 1570                 1575             


Ala His  Arg Ala Arg Tyr Phe  Trp Gly Asn Leu Pro  Gly Met Asn 
    1580                 1585                 1590             


Arg Pro  Leu Ala Ser Thr Val  Asn Asp Lys Leu Glu  Leu Gln Glu 
    1595                 1600                 1605             


Cys Leu  Glu His Gly Arg Ile  Ala Lys Phe Ser Lys  Val Arg Thr 
    1610                 1615                 1620             


Ile Thr  Thr Arg Ser Asn Ser  Ile Lys Gln Gly Lys  Asp Gln His 
    1625                 1630                 1635             


Phe Pro  Val Phe Met Asn Glu  Lys Glu Asp Ile Leu  Trp Cys Thr 
    1640                 1645                 1650             


Glu Met  Glu Arg Val Phe Gly  Phe Pro Val His Tyr  Thr Asp Val 
    1655                 1660                 1665             


Ser Asn  Met Ser Arg Leu Ala  Arg Gln Arg Leu Leu  Gly Arg Ser 
    1670                 1675                 1680             


Trp Ser  Val Pro Val Ile Arg  His Leu Phe Ala Pro  Leu Lys Glu 
    1685                 1690                 1695             


Tyr Phe  Ala Cys 
    1700         


<210>  20
<211>  5109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - dCas9-DNMT3A fusion protein

<400>  20
gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggcaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggacgctatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggcga caaaaggccg gcggccacga aaaaggccgg acaggccaaa     4140

aagaaaaagc tcgagggcgg aggcgggagc ggatccccct cccggctcca gatgttcttc     4200

gctaataacc acgaccagga atttgaccct ccaaaggttt acccacctgt cccagctgag     4260

aagaggaagc ccatccgggt gctgtctctc tttgatggaa tcgctacagg gctcctggtg     4320

ctgaaggact tgggcattca ggtggaccgc tacattgcct cggaggtgtg tgaggactcc     4380

atcacggtgg gcatggtgcg gcaccagggg aagatcatgt acgtcgggga cgtccgcagc     4440

gtcacacaga agcatatcca ggagtggggc ccattcgatc tggtgattgg gggcagtccc     4500

tgcaatgacc tctccatcgt caaccctgct cgcaagggcc tctacgaggg cactggccgg     4560

ctcttctttg agttctaccg cctcctgcat gatgcgcggc ccaaggaggg agatgatcgc     4620

cccttcttct ggctctttga gaatgtggtg gccatgggcg ttagtgacaa gagggacatc     4680

tcgcgatttc tcgagtccaa ccctgtgatg attgatgcca aagaagtgtc agctgcacac     4740

agggcccgct acttctgggg taaccttccc ggtatgaaca ggccgttggc atccactgtg     4800

aatgataagc tggagctgca ggagtgtctg gagcatggca ggatagccaa gttcagcaaa     4860

gtgaggacca ttactacgag gtcaaactcc ataaagcagg gcaaagacca gcattttcct     4920

gtgttcatga atgagaaaga ggacatctta tggtgcactg aaatggaaag ggtatttggt     4980

ttcccagtcc actatactga cgtgtccaac atgagccgct tggcgaggca gagactgctg     5040

ggccggtcat ggagcgtgcc agtcatccgc cacctcttcg ctccgctgaa ggagtatttt     5100

gcgtgtgtg                                                             5109


<210>  21
<211>  14092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK546 plasmid

<400>  21
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggagacgt gtacacgtct ctgttttaga gctagaaata gcaagttaaa ataaggctag     2940

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttgaattc gctagctagg     3000

tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     3060

cagtccccga gaagttgggg ggaggggtcg gcaattgatc cggtgcctag agaaggtggc     3120

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     3180

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     3240

ccagaacaca ggaccggtgc caccatggac tataaggacc acgacggaga ctacaaggat     3300

catgatattg attacaaaga cgatgacgat aagatggccc caaagaagaa gcggaaggtc     3360

ggtatccacg gagtcccagc agccgacaag aagtacagca tcggcctggc catcggcacc     3420

aactctgtgg gctgggccgt gatcaccgac gagtacaagg tgcccagcaa gaaattcaag     3480

gtgctgggca acaccgaccg gcacagcatc aagaagaacc tgatcggagc cctgctgttc     3540

gacagcggcg aaacagccga ggccacccgg ctgaagagaa ccgccagaag aagatacacc     3600

agacggaaga accggatctg ctatctgcaa gagatcttca gcaacgagat ggccaaggtg     3660

gacgacagct tcttccacag actggaagag tccttcctgg tggaagagga taagaagcac     3720

gagcggcacc ccatcttcgg caacatcgtg gacgaggtgg cctaccacga gaagtacccc     3780

accatctacc acctgagaaa gaaactggtg gacagcaccg acaaggccga cctgcggctg     3840

atctatctgg ccctggccca catgatcaag ttccggggcc acttcctgat cgagggcgac     3900

ctgaaccccg acaacagcga cgtggacaag ctgttcatcc agctggtgca gacctacaac     3960

cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg acgccaaggc catcctgtct     4020

gccagactga gcaagagcag acggctggaa aatctgatcg cccagctgcc cggcgagaag     4080

aagaatggcc tgttcggcaa cctgattgcc ctgagcctgg gcctgacccc caacttcaag     4140

agcaacttcg acctggccga ggatgccaaa ctgcagctga gcaaggacac ctacgacgac     4200

gacctggaca acctgctggc ccagatcggc gaccagtacg ccgacctgtt tctggccgcc     4260

aagaacctgt ccgacgccat cctgctgagc gacatcctga gagtgaacac cgagatcacc     4320

aaggcccccc tgagcgcctc tatgatcaag agatacgacg agcaccacca ggacctgacc     4380

ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt acaaagagat tttcttcgac     4440

cagagcaaga acggctacgc cggctacatt gacggcggag ccagccagga agagttctac     4500

aagttcatca agcccatcct ggaaaagatg gacggcaccg aggaactgct cgtgaagctg     4560

aacagagagg acctgctgcg gaagcagcgg accttcgaca acggcagcat cccccaccag     4620

atccacctgg gagagctgca cgccattctg cggcggcagg aagattttta cccattcctg     4680

aaggacaacc gggaaaagat cgagaagatc ctgaccttcc gcatccccta ctacgtgggc     4740

cctctggcca ggggaaacag cagattcgcc tggatgacca gaaagagcga ggaaaccatc     4800

accccctgga acttcgagga agtggtggac aagggcgctt ccgcccagag cttcatcgag     4860

cggatgacca acttcgataa gaacctgccc aacgagaagg tgctgcccaa gcacagcctg     4920

ctgtacgagt acttcaccgt gtataacgag ctgaccaaag tgaaatacgt gaccgaggga     4980

atgagaaagc ccgccttcct gagcggcgag cagaaaaagg ccatcgtgga cctgctgttc     5040

aagaccaacc ggaaagtgac cgtgaagcag ctgaaagagg actacttcaa gaaaatcgag     5100

tgcttcgact ccgtggaaat ctccggcgtg gaagatcggt tcaacgcctc cctgggcaca     5160

taccacgatc tgctgaaaat tatcaaggac aaggacttcc tggacaatga ggaaaacgag     5220

gacattctgg aagatatcgt gctgaccctg acactgtttg aggacagaga gatgatcgag     5280

gaacggctga aaacctatgc ccacctgttc gacgacaaag tgatgaagca gctgaagcgg     5340

cggagataca ccggctgggg caggctgagc cggaagctga tcaacggcat ccgggacaag     5400

cagtccggca agacaatcct ggatttcctg aagtccgacg gcttcgccaa cagaaacttc     5460

atgcagctga tccacgacga cagcctgacc tttaaagagg acatccagaa agcccaggtg     5520

tccggccagg gcgatagcct gcacgagcac attgccaatc tggccggcag ccccgccatt     5580

aagaagggca tcctgcagac agtgaaggtg gtggacgagc tcgtgaaagt gatgggccgg     5640

cacaagcccg agaacatcgt gatcgaaatg gccagagaga accagaccac ccagaaggga     5700

cagaagaaca gccgcgagag aatgaagcgg atcgaagagg gcatcaaaga gctgggcagc     5760

cagatcctga aagaacaccc cgtggaaaac acccagctgc agaacgagaa gctgtacctg     5820

tactacctgc agaatgggcg ggatatgtac gtggaccagg aactggacat caaccggctg     5880

tccgactacg atgtggacgc tatcgtgcct cagagctttc tgaaggacga ctccatcgac     5940

aacaaggtgc tgaccagaag cgacaagaac cggggcaaga gcgacaacgt gccctccgaa     6000

gaggtcgtga agaagatgaa gaactactgg cggcagctgc tgaacgccaa gctgattacc     6060

cagagaaagt tcgacaatct gaccaaggcc gagagaggcg gcctgagcga actggataag     6120

gccggcttca tcaagagaca gctggtggaa acccggcaga tcacaaagca cgtggcacag     6180

atcctggact cccggatgaa cactaagtac gacgagaatg acaagctgat ccgggaagtg     6240

aaagtgatca ccctgaagtc caagctggtg tccgatttcc ggaaggattt ccagttttac     6300

aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg cctacctgaa cgccgtcgtg     6360

ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg agttcgtgta cggcgactac     6420

aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc aggaaatcgg caaggctacc     6480

gccaagtact tcttctacag caacatcatg aactttttca agaccgagat taccctggcc     6540

aacggcgaga tccggaagcg gcctctgatc gagacaaacg gcgaaaccgg ggagatcgtg     6600

tgggataagg gccgggattt tgccaccgtg cggaaagtgc tgagcatgcc ccaagtgaat     6660

atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca aagagtctat cctgcccaag     6720

aggaacagcg ataagctgat cgccagaaag aaggactggg accctaagaa gtacggcggc     6780

ttcgacagcc ccaccgtggc ctattctgtg ctggtggtgg ccaaagtgga aaagggcaag     6840

tccaagaaac tgaagagtgt gaaagagctg ctggggatca ccatcatgga aagaagcagc     6900

ttcgagaaga atcccatcga ctttctggaa gccaagggct acaaagaagt gaaaaaggac     6960

ctgatcatca agctgcctaa gtactccctg ttcgagctgg aaaacggccg gaagagaatg     7020

ctggcctctg ccggcgaact gcagaaggga aacgaactgg ccctgccctc caaatatgtg     7080

aacttcctgt acctggccag ccactatgag aagctgaagg gctcccccga ggataatgag     7140

cagaaacagc tgtttgtgga acagcacaag cactacctgg acgagatcat cgagcagatc     7200

agcgagttct ccaagagagt gatcctggcc gacgctaatc tggacaaagt gctgtccgcc     7260

tacaacaagc accgggataa gcccatcaga gagcaggccg agaatatcat ccacctgttt     7320

accctgacca atctgggagc ccctgccgcc ttcaagtact ttgacaccac catcgaccgg     7380

aagaggtaca ccagcaccaa agaggtgctg gacgccaccc tgatccacca gagcatcacc     7440

ggcctgtacg agacacggat cgacctgtct cagctgggag gcgacaaaag gccggcggcc     7500

acgaaaaagg ccggacaggc caaaaagaaa aagctcgagg gcggaggcgg gagcggatcc     7560

ccctcccggc tccagatgtt cttcgctaat aaccacgacc aggaatttga ccctccaaag     7620

gtttacccac ctgtcccagc tgagaagagg aagcccatcc gggtgctgtc tctctttgat     7680

ggaatcgcta cagggctcct ggtgctgaag gacttgggca ttcaggtgga ccgctacatt     7740

gcctcggagg tgtgtgagga ctccatcacg gtgggcatgg tgcggcacca ggggaagatc     7800

atgtacgtcg gggacgtccg cagcgtcaca cagaagcata tccaggagtg gggcccattc     7860

gatctggtga ttgggggcag tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag     7920

ggcctctacg agggcactgg ccggctcttc tttgagttct accgcctcct gcatgatgcg     7980

cggcccaagg agggagatga tcgccccttc ttctggctct ttgagaatgt ggtggccatg     8040

ggcgttagtg acaagaggga catctcgcga tttctcgagt ccaaccctgt gatgattgat     8100

gccaaagaag tgtcagctgc acacagggcc cgctacttct ggggtaacct tcccggtatg     8160

aacaggccgt tggcatccac tgtgaatgat aagctggagc tgcaggagtg tctggagcat     8220

ggcaggatag ccaagttcag caaagtgagg accattacta cgaggtcaaa ctccataaag     8280

cagggcaaag accagcattt tcctgtgttc atgaatgaga aagaggacat cttatggtgc     8340

actgaaatgg aaagggtatt tggtttccca gtccactata ctgacgtgtc caacatgagc     8400

cgcttggcga ggcagagact gctgggccgg tcatggagcg tgccagtcat ccgccacctc     8460

ttcgctccgc tgaaggagta ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca     8520

aacttctctc tgctgaaaca agccggagat gtcgaagaga atcctggacc gaccgagtac     8580

aagcccacgg tgcgcctcgc cacccgcgac gacgtcccca gggccgtacg caccctcgcc     8640

gccgcgttcg ccgactaccc cgccacgcgc cacaccgtcg atccggaccg ccacatcgag     8700

cgggtcaccg agctgcaaga actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg     8760

tgggtcgcgg acgacggcgc cgcggtggcg gtctggacca cgccggagag cgtcgaagcg     8820

ggggcggtgt tcgccgagat cggcccgcgc atggccgagt tgagcggttc ccggctggcc     8880

gcgcagcaac agatggaagg cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc     8940

ctggccaccg tcggagtctc gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg     9000

ctccccggag tggaggcggc cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg     9060

ccccgcaacc tccccttcta cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg     9120

cccgaaggac cgcgcacctg gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc     9180

gacaatcaac ctctggatta caaaatttgt gaaagattga ctggtattct taactatgtt     9240

gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc tattgcttcc     9300

cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct ttatgaggag     9360

ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc     9420

actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc tttccccctc     9480

cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac aggggctcgg     9540

ctgttgggca ctgacaattc cgtggtgttg tcggggaaat catcgtcctt tccttggctg     9600

ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt cccttcggcc     9660

ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt     9720

cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc gcgtcgactt     9780

taagaccaat gacttacaag gcagctgtag atcttagcca ctttttaaaa gaaaaggggg     9840

gactggaagg gctaattcac tcccaacgaa gacaagatct gctttttgct tgtactgggt     9900

ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg aacccactgc     9960

ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg    10020

actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc tctagcaggg    10080

cccgtttaaa cccgctgatc agcctcgact gtgccttcta gttgccagcc atctgttgtt    10140

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa    10200

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg    10260

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggatgcg    10320

gtgggctcta tggcttctga ggcggaaaga accagctggg gctctagggg gtatccccac    10380

gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct    10440

acacttgcca gcgccctagc gcccgctcct ttcgctttct tcccttcctt tctcgccacg    10500

ttcgccggct ttccccgtca agctctaaat cgggggctcc ctttagggtt ccgatttagt    10560

gctttacggc acctcgaccc caaaaaactt gattagggtg atggttcacg tagtgggcca    10620

tcgccctgat agacggtttt tcgccctttg acgttggagt ccacgttctt taatagtgga    10680

ctcttgttcc aaactggaac aacactcaac cctatctcgg tctattcttt tgatttataa    10740

gggattttgc cgatttcggc ctattggtta aaaaatgagc tgatttaaca aaaatttaac    10800

gcgaattaat tctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag    10860

caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt ggaaagtccc    10920

caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca gcaaccatag    10980

tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc cattctccgc    11040

cccatggctg actaattttt tttatttatg cagaggccga ggccgcctct gcctctgagc    11100

tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa aagctcccgg    11160

gagcttgtat atccattttc ggatctgatc agcacgtgtt gacaattaat catcggcata    11220

gtatatcggc atagtataat acgacaaggt gaggaactaa accatggcca agttgaccag    11280

tgccgttccg gtgctcaccg cgcgcgacgt cgccggagcg gtcgagttct ggaccgaccg    11340

gctcgggttc tcccgggact tcgtggagga cgacttcgcc ggtgtggtcc gggacgacgt    11400

gaccctgttc atcagcgcgg tccaggacca ggtggtgccg gacaacaccc tggcctgggt    11460

gtgggtgcgc ggcctggacg agctgtacgc cgagtggtcg gaggtcgtgt ccacgaactt    11520

ccgggacgcc tccgggccgg ccatgaccga gatcggcgag cagccgtggg ggcgggagtt    11580

cgccctgcgc gacccggccg gcaactgcgt gcacttcgtg gccgaggagc aggactgaca    11640

cgtgctacga gatttcgatt ccaccgccgc cttctatgaa aggttgggct tcggaatcgt    11700

tttccgggac gccggctgga tgatcctcca gcgcggggat ctcatgctgg agttcttcgc    11760

ccaccccaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa    11820

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa    11880

tgtatcttat catgtctgta taccgtcgac ctctagctag agcttggcgt aatcatggtc    11940

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg    12000

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt    12060

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg    12120

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga    12180

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat    12240

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca    12300

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc    12360

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata    12420

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc    12480

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc    12540

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga    12600

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc    12660

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag    12720

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag    12780

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag    12840

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca    12900

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga    12960

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat    13020

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga    13080

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg    13140

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga    13200

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc    13260

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac    13320

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc    13380

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc    13440

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc    13500

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt    13560

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc    13620

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg    13680

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag    13740

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat    13800

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc    13860

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa    13920

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta    13980

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa    14040

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg ac            14092


<210>  22
<211>  13812
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK539 plasmid

<400>  22
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggagacgt gtacacgtct ctgttttaga gctagaaata gcaagttaaa ataaggctag     2940

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttgaattc gctagctagg     3000

tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     3060

cagtccccga gaagttgggg ggaggggtcg gcaattgatc cggtgcctag agaaggtggc     3120

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     3180

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     3240

ccagaacaca ggaccggtgc caccatggac tataaggacc acgacggaga ctacaaggat     3300

catgatattg attacaaaga cgatgacgat aagatggccc caaagaagaa gcggaaggtc     3360

ggtatccacg gagtcccagc agccgacaag aagtacagca tcggcctggc catcggcacc     3420

aactctgtgg gctgggccgt gatcaccgac gagtacaagg tgcccagcaa gaaattcaag     3480

gtgctgggca acaccgaccg gcacagcatc aagaagaacc tgatcggagc cctgctgttc     3540

gacagcggcg aaacagccga ggccacccgg ctgaagagaa ccgccagaag aagatacacc     3600

agacggaaga accggatctg ctatctgcaa gagatcttca gcaacgagat ggccaaggtg     3660

gacgacagct tcttccacag actggaagag tccttcctgg tggaagagga taagaagcac     3720

gagcggcacc ccatcttcgg caacatcgtg gacgaggtgg cctaccacga gaagtacccc     3780

accatctacc acctgagaaa gaaactggtg gacagcaccg acaaggccga cctgcggctg     3840

atctatctgg ccctggccca catgatcaag ttccggggcc acttcctgat cgagggcgac     3900

ctgaaccccg acaacagcga cgtggacaag ctgttcatcc agctggtgca gacctacaac     3960

cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg acgccaaggc catcctgtct     4020

gccagactga gcaagagcag acggctggaa aatctgatcg cccagctgcc cggcgagaag     4080

aagaatggcc tgttcggcaa cctgattgcc ctgagcctgg gcctgacccc caacttcaag     4140

agcaacttcg acctggccga ggatgccaaa ctgcagctga gcaaggacac ctacgacgac     4200

gacctggaca acctgctggc ccagatcggc gaccagtacg ccgacctgtt tctggccgcc     4260

aagaacctgt ccgacgccat cctgctgagc gacatcctga gagtgaacac cgagatcacc     4320

aaggcccccc tgagcgcctc tatgatcaag agatacgacg agcaccacca ggacctgacc     4380

ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt acaaagagat tttcttcgac     4440

cagagcaaga acggctacgc cggctacatt gacggcggag ccagccagga agagttctac     4500

aagttcatca agcccatcct ggaaaagatg gacggcaccg aggaactgct cgtgaagctg     4560

aacagagagg acctgctgcg gaagcagcgg accttcgaca acggcagcat cccccaccag     4620

atccacctgg gagagctgca cgccattctg cggcggcagg aagattttta cccattcctg     4680

aaggacaacc gggaaaagat cgagaagatc ctgaccttcc gcatccccta ctacgtgggc     4740

cctctggcca ggggaaacag cagattcgcc tggatgacca gaaagagcga ggaaaccatc     4800

accccctgga acttcgagga agtggtggac aagggcgctt ccgcccagag cttcatcgag     4860

cggatgacca acttcgataa gaacctgccc aacgagaagg tgctgcccaa gcacagcctg     4920

ctgtacgagt acttcaccgt gtataacgag ctgaccaaag tgaaatacgt gaccgaggga     4980

atgagaaagc ccgccttcct gagcggcgag cagaaaaagg ccatcgtgga cctgctgttc     5040

aagaccaacc ggaaagtgac cgtgaagcag ctgaaagagg actacttcaa gaaaatcgag     5100

tgcttcgact ccgtggaaat ctccggcgtg gaagatcggt tcaacgcctc cctgggcaca     5160

taccacgatc tgctgaaaat tatcaaggac aaggacttcc tggacaatga ggaaaacgag     5220

gacattctgg aagatatcgt gctgaccctg acactgtttg aggacagaga gatgatcgag     5280

gaacggctga aaacctatgc ccacctgttc gacgacaaag tgatgaagca gctgaagcgg     5340

cggagataca ccggctgggg caggctgagc cggaagctga tcaacggcat ccgggacaag     5400

cagtccggca agacaatcct ggatttcctg aagtccgacg gcttcgccaa cagaaacttc     5460

atgcagctga tccacgacga cagcctgacc tttaaagagg acatccagaa agcccaggtg     5520

tccggccagg gcgatagcct gcacgagcac attgccaatc tggccggcag ccccgccatt     5580

aagaagggca tcctgcagac agtgaaggtg gtggacgagc tcgtgaaagt gatgggccgg     5640

cacaagcccg agaacatcgt gatcgaaatg gccagagaga accagaccac ccagaaggga     5700

cagaagaaca gccgcgagag aatgaagcgg atcgaagagg gcatcaaaga gctgggcagc     5760

cagatcctga aagaacaccc cgtggaaaac acccagctgc agaacgagaa gctgtacctg     5820

tactacctgc agaatgggcg ggatatgtac gtggaccagg aactggacat caaccggctg     5880

tccgactacg atgtggacgc tatcgtgcct cagagctttc tgaaggacga ctccatcgac     5940

aacaaggtgc tgaccagaag cgacaagaac cggggcaaga gcgacaacgt gccctccgaa     6000

gaggtcgtga agaagatgaa gaactactgg cggcagctgc tgaacgccaa gctgattacc     6060

cagagaaagt tcgacaatct gaccaaggcc gagagaggcg gcctgagcga actggataag     6120

gccggcttca tcaagagaca gctggtggaa acccggcaga tcacaaagca cgtggcacag     6180

atcctggact cccggatgaa cactaagtac gacgagaatg acaagctgat ccgggaagtg     6240

aaagtgatca ccctgaagtc caagctggtg tccgatttcc ggaaggattt ccagttttac     6300

aaagtgcgcg agatcaacaa ctaccaccac gcccacgacg cctacctgaa cgccgtcgtg     6360

ggaaccgccc tgatcaaaaa gtaccctaag ctggaaagcg agttcgtgta cggcgactac     6420

aaggtgtacg acgtgcggaa gatgatcgcc aagagcgagc aggaaatcgg caaggctacc     6480

gccaagtact tcttctacag caacatcatg aactttttca agaccgagat taccctggcc     6540

aacggcgaga tccggaagcg gcctctgatc gagacaaacg gcgaaaccgg ggagatcgtg     6600

tgggataagg gccgggattt tgccaccgtg cggaaagtgc tgagcatgcc ccaagtgaat     6660

atcgtgaaaa agaccgaggt gcagacaggc ggcttcagca aagagtctat cctgcccaag     6720

aggaacagcg ataagctgat cgccagaaag aaggactggg accctaagaa gtacggcggc     6780

ttcgacagcc ccaccgtggc ctattctgtg ctggtggtgg ccaaagtgga aaagggcaag     6840

tccaagaaac tgaagagtgt gaaagagctg ctggggatca ccatcatgga aagaagcagc     6900

ttcgagaaga atcccatcga ctttctggaa gccaagggct acaaagaagt gaaaaaggac     6960

ctgatcatca agctgcctaa gtactccctg ttcgagctgg aaaacggccg gaagagaatg     7020

ctggcctctg ccggcgaact gcagaaggga aacgaactgg ccctgccctc caaatatgtg     7080

aacttcctgt acctggccag ccactatgag aagctgaagg gctcccccga ggataatgag     7140

cagaaacagc tgtttgtgga acagcacaag cactacctgg acgagatcat cgagcagatc     7200

agcgagttct ccaagagagt gatcctggcc gacgctaatc tggacaaagt gctgtccgcc     7260

tacaacaagc accgggataa gcccatcaga gagcaggccg agaatatcat ccacctgttt     7320

accctgacca atctgggagc ccctgccgcc ttcaagtact ttgacaccac catcgaccgg     7380

aagaggtaca ccagcaccaa agaggtgctg gacgccaccc tgatccacca gagcatcacc     7440

ggcctgtacg agacacggat cgacctgtct cagctgggag gcgacaaaag gccggcggcc     7500

acgaaaaagg ccggacaggc caaaaagaaa aagctcgagg gcggaggcgg gagcggatcc     7560

ccctcccggc tccagatgtt cttcgctaat aaccacgacc aggaatttga ccctccaaag     7620

gtttacccac ctgtcccagc tgagaagagg aagcccatcc gggtgctgtc tctctttgat     7680

ggaatcgcta cagggctcct ggtgctgaag gacttgggca ttcaggtgga ccgctacatt     7740

gcctcggagg tgtgtgagga ctccatcacg gtgggcatgg tgcggcacca ggggaagatc     7800

atgtacgtcg gggacgtccg cagcgtcaca cagaagcata tccaggagtg gggcccattc     7860

gatctggtga ttgggggcag tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag     7920

ggcctctacg agggcactgg ccggctcttc tttgagttct accgcctcct gcatgatgcg     7980

cggcccaagg agggagatga tcgccccttc ttctggctct ttgagaatgt ggtggccatg     8040

ggcgttagtg acaagaggga catctcgcga tttctcgagt ccaaccctgt gatgattgat     8100

gccaaagaag tgtcagctgc acacagggcc cgctacttct ggggtaacct tcccggtatg     8160

aacaggccgt tggcatccac tgtgaatgat aagctggagc tgcaggagtg tctggagcat     8220

ggcaggatag ccaagttcag caaagtgagg accattacta cgaggtcaaa ctccataaag     8280

cagggcaaag accagcattt tcctgtgttc atgaatgaga aagaggacat cttatggtgc     8340

actgaaatgg aaagggtatt tggtttccca gtccactata ctgacgtgtc caacatgagc     8400

cgcttggcga ggcagagact gctgggccgg tcatggagcg tgccagtcat ccgccacctc     8460

ttcgctccgc tgaaggagta ttttgcgtgt gtgtccggcc ggggccggcc cggatccggc     8520

gcaacaaact tctctctgct gaaacaagcc ggagatgtcg aagagaatcc tggaccgatg     8580

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc     8640

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc     8700

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc     8760

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag     8820

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc     8880

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg     8940

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag     9000

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc     9060

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac     9120

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     9180

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     9240

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaaagc     9300

ggccgcgtcg acaatcaacc tctggattac aaaatttgtg aaagattgac tggtattctt     9360

aactatgttg ctccttttac gctatgtgga tacgctgctt taatgccttt gtatcatgct     9420

attgcttccc gtatggcttt cattttctcc tccttgtata aatcctggtt gctgtctctt     9480

tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac     9540

gcaaccccca ctggttgggg cattgccacc acctgtcagc tcctttccgg gactttcgct     9600

ttccccctcc ctattgccac ggcggaactc atcgccgcct gccttgcccg ctgctggaca     9660

ggggctcggc tgttgggcac tgacaattcc gtggtgttgt cggggaagct gacgtccttt     9720

ccatggctgc tcgcctgtgt tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc     9780

ccttcggccc tcaatccagc ggaccttcct tcccgcggcc tgctgccggc tctgcggcct     9840

cttccgcgtc ttcgccttcg ccctcagacg agtcggatct ccctttgggc cgcctccccg     9900

cctggaattc gagctcggta cctttaagac caatgactta caaggcagct gtagatctta     9960

gccacttttt aaaagaaaag gggggactgg aagggctaat tcactcccaa cgaagacaag    10020

atctgctttt tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct    10080

ctggctaact agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag    10140

tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt    10200

cagtgtggaa aatctctagc agtagtagtt catgtcatct tattattcag tatttataac    10260

ttgcaaagaa atgaatatca gagagtgaga ggaacttgtt tattgcagct tataatggtt    10320

acaaataaag caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta    10380

gttgtggttt gtccaaactc atcaatgtat cttatcatgt ctggctctag ctatcccgcc    10440

cctaactccg cccatcccgc ccctaactcc gcccagttcc gcccattctc cgccccatgg    10500

ctgactaatt ttttttattt atgcagaggc cgaggccgcc tcggcctctg agctattcca    10560

gaagtagtga ggaggctttt ttggaggcct agggacgtac ccaattcgcc ctatagtgag    10620

tcgtattacg cgcgctcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc    10680

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa    10740

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atgggacgcg    10800

ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta cgcgcagcgt gaccgctaca    10860

cttgccagcg ccctagcgcc cgctcctttc gctttcttcc cttcctttct cgccacgttc    10920

gccggctttc cccgtcaagc tctaaatcgg gggctccctt tagggttccg atttagtgct    10980

ttacggcacc tcgaccccaa aaaacttgat tagggtgatg gttcacgtag tgggccatcg    11040

ccctgataga cggtttttcg ccctttgacg ttggagtcca cgttctttaa tagtggactc    11100

ttgttccaaa ctggaacaac actcaaccct atctcggtct attcttttga tttataaggg    11160

attttgccga tttcggccta ttggttaaaa aatgagctga tttaacaaaa atttaacgcg    11220

aattttaaca aaatattaac gcttacaatt taggtgccgg ccatgaccga gatcggcgag    11280

cagccgtggg ggcgggagtt cgccctgcgc gacccggccg gcaactgcgt gcacttcgtg    11340

gccgaggagc aggactgaca cgtgctacga gatttcgatt ccaccgccgc cttctatgaa    11400

aggttgggct tcggaatcgt tttccgggac gccggctgga tgatcctcca gcgcggggat    11460

ctcatgctgg agttcttcgc ccaccccaac ttgtttattg cagcttataa tggttacaaa    11520

taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt    11580

ggtttgtcca aactcatcaa tgtatcttat catgtctgta taccgtcgac ctctagctag    11640

agcttggcgt aatcatggtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt    11700

ccacacaaca tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc    11760

taactcacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc    11820

cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct    11880

tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca    11940

gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac    12000

atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt    12060

ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg    12120

cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc    12180

tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc    12240

gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc    12300

aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac    12360

tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt    12420

aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct    12480

aactacggct acactagaag aacagtattt ggtatctgcg ctctgctgaa gccagttacc    12540

ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt    12600

ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg    12660

atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc    12720

atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa    12780

tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag    12840

gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg    12900

tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga    12960

gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag    13020

cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa    13080

gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc    13140

atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca    13200

aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg    13260

atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat    13320

aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc    13380

aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg    13440

gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg    13500

gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt    13560

gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca    13620

ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata    13680

ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac    13740

atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa    13800

gtgccacctg ac                                                        13812


<210>  23
<211>  13039
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK500 plasmid

<400>  23
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgctgctca gggtagatag ctggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtt ctagagcgct gccaccatgg acaagaagta cagcatcggc     3300

ctggacatcg gcaccaactc tgtgggctgg gccgtgatca ccgacgagta caaggtgccc     3360

agcaagaaat tcaaggtgct gggcaacacc gaccggcaca gcatcaagaa gaacctgatc     3420

ggagccctgc tgttcgacag cggcgaaaca gccgaggcca cccggctgaa gagaaccgcc     3480

agaagaagat acaccagacg gaagaaccgg atctgctatc tgcaagagat cttcagcaac     3540

gagatggcca aggtggacga cagcttcttc cacagactgg aagagtcctt cctggtggaa     3600

gaggataaga agcacgagcg gcaccccatc ttcggcaaca tcgtggacga ggtggcctac     3660

cacgagaagt accccaccat ctaccacctg agaaagaaac tggtggacag caccgacaag     3720

gccgacctgc ggctgatcta tctggccctg gcccacatga tcaagttccg gggccacttc     3780

ctgatcgagg gcgacctgaa ccccgacaac agcgacgtgg acaagctgtt catccagctg     3840

gtgcagacct acaaccagct gttcgaggaa aaccccatca acgccagcgg cgtggacgcc     3900

aaggccatcc tgtctgccag actgagcaag agcagacggc tggaaaatct gatcgcccag     3960

ctgcccggcg agaagaagaa tggcctgttc ggaaacctga ttgccctgag cctgggcctg     4020

acccccaact tcaagagcaa cttcgacctg gccgaggatg ccaaactgca gctgagcaag     4080

gacacctacg acgacgacct ggacaacctg ctggcccaga tcggcgacca gtacgccgac     4140

ctgtttctgg ccgccaagaa cctgtccgac gccatcctgc tgagcgacat cctgagagtg     4200

aacaccgaga tcaccaaggc ccccctgagc gcctctatga tcaagagata cgacgagcac     4260

caccaggacc tgaccctgct gaaagctctc gtgcggcagc agctgcctga gaagtacaaa     4320

gagattttct tcgaccagag caagaacggc tacgccggct acattgacgg cggagccagc     4380

caggaagagt tctacaagtt catcaagccc atcctggaaa agatggacgg caccgaggaa     4440

ctgctcgtga agctgaacag agaggacctg ctgcggaagc agcggacctt cgacaacggc     4500

agcatccccc accagatcca cctgggagag ctgcacgcca ttctgcggcg gcaggaagat     4560

ttttacccat tcctgaagga caaccgggaa aagatcgaga agatcctgac cttccgcatc     4620

ccctactacg tgggccctct ggccagggga aacagcagat tcgcctggat gaccagaaag     4680

agcgaggaaa ccatcacccc ctggaacttc gaggaagtgg tggacaaggg cgcttccgcc     4740

cagagcttca tcgagcggat gaccaacttc gataagaacc tgcccaacga gaaggtgctg     4800

cccaagcaca gcctgctgta cgagtacttc accgtgtata acgagctgac caaagtgaaa     4860

tacgtgaccg agggaatgag aaagcccgcc ttcctgagcg gcgagcagaa aaaggccatc     4920

gtggacctgc tgttcaagac caaccggaaa gtgaccgtga agcagctgaa agaggactac     4980

ttcaagaaaa tcgagtgctt cgactccgtg gaaatctccg gcgtggaaga tcggttcaac     5040

gcctccctgg gcacatacca cgatctgctg aaaattatca aggacaagga cttcctggac     5100

aatgaggaaa acgaggacat tctggaagat atcgtgctga ccctgacact gtttgaggac     5160

agagagatga tcgaggaacg gctgaaaacc tatgcccacc tgttcgacga caaagtgatg     5220

aagcagctga agcggcggag atacaccggc tggggcaggc tgagccggaa gctgatcaac     5280

ggcatccggg acaagcagtc cggcaagaca atcctggatt tcctgaagtc cgacggcttc     5340

gccaacagaa acttcatgca gctgatccac gacgacagcc tgacctttaa agaggacatc     5400

cagaaagccc aggtgtccgg ccagggcgat agcctgcacg agcacattgc caatctggcc     5460

ggcagccccg ccattaagaa gggcatcctg cagacagtga aggtggtgga cgagctcgtg     5520

aaagtgatgg gccggcacaa gcccgagaac atcgtgatcg aaatggccag agagaaccag     5580

accacccaga agggacagaa gaacagccgc gagagaatga agcggatcga agagggcatc     5640

aaagagctgg gcagccagat cctgaaagaa caccccgtgg aaaacaccca gctgcagaac     5700

gagaagctgt acctgtacta cctgcagaat gggcgggata tgtacgtgga ccaggaactg     5760

gacatcaacc ggctgtccga ctacgatgtg gaccatatcg tgcctcagag ctttctgaag     5820

gacgactcca tcgacaacaa ggtgctgacc agaagcgaca agaaccgggg caagagcgac     5880

aacgtgccct ccgaagaggt cgtgaagaag atgaagaact actggcggca gctgctgaac     5940

gccaagctga ttacccagag aaagttcgac aatctgacca aggccgagag aggcggcctg     6000

agcgaactgg ataaggccgg cttcatcaag agacagctgg tggaaacccg gcagatcaca     6060

aagcacgtgg cacagatcct ggactcccgg atgaacacta agtacgacga gaatgacaag     6120

ctgatccggg aagtgaaagt gatcaccctg aagtccaagc tggtgtccga tttccggaag     6180

gatttccagt tttacaaagt gcgcgagatc aacaactacc accacgccca cgacgcctac     6240

ctgaacgccg tcgtgggaac cgccctgatc aaaaagtacc ctaagctgga aagcgagttc     6300

gtgtacggcg actacaaggt gtacgacgtg cggaagatga tcgccaagag cgagcaggaa     6360

atcggcaagg ctaccgccaa gtacttcttc tacagcaaca tcatgaactt tttcaagacc     6420

gagattaccc tggccaacgg cgagatccgg aagcggcctc tgatcgagac aaacggcgaa     6480

accggggaga tcgtgtggga taagggccgg gattttgcca ccgtgcggaa agtgctgagc     6540

atgccccaag tgaatatcgt gaaaaagacc gaggtgcaga caggcggctt cagcaaagag     6600

tctatcctgc ccaagaggaa cagcgataag ctgatcgcca gaaagaagga ctgggaccct     6660

aagaagtacg gcggcttcga cagccccacc gtggcctatt ctgtgctggt ggtggccaaa     6720

gtggaaaagg gcaagtccaa gaaactgaag agtgtgaaag agctgctggg gatcaccatc     6780

atggaaagaa gcagcttcga gaagaatccc atcgactttc tggaagccaa gggctacaaa     6840

gaagtgaaaa aggacctgat catcaagctg cctaagtact ccctgttcga gctggaaaac     6900

ggccggaaga gaatgctggc ctctgccggc gaactgcaga agggaaacga actggccctg     6960

ccctccaaat atgtgaactt cctgtacctg gccagccact atgagaagct gaagggctcc     7020

cccgaggata atgagcagaa acagctgttt gtggaacagc acaagcacta cctggacgag     7080

atcatcgagc agatcagcga gttctccaag agagtgatcc tggccgacgc taatctggac     7140

aaagtgctgt ccgcctacaa caagcaccgg gataagccca tcagagagca ggccgagaat     7200

atcatccacc tgtttaccct gaccaatctg ggagcccctg ccgccttcaa gtactttgac     7260

accaccatcg accggaagag gtacaccagc accaaagagg tgctggacgc caccctgatc     7320

caccagagca tcaccggcct gtacgagaca cggatcgacc tgtctcagct gggaggcgac     7380

aagcgacctg ccgccacaaa gaaggctgga caggctaaga agaagaaaga ttacaaagac     7440

gatgacgata agggatccgg cgcaacaaac ttctctctgc tgaaacaagc cggagatgtc     7500

gaagagaatc ctggaccgac cgagtacaag cccacggtgc gcctcgccac ccgcgacgac     7560

gtccccaggg ccgtacgcac cctcgccgcc gcgttcgccg actaccccgc cacgcgccac     7620

accgtcgatc cggaccgcca catcgagcgg gtcaccgagc tgcaagaact cttcctcacg     7680

cgcgtcgggc tcgacatcgg caaggtgtgg gtcgcggacg acggcgccgc ggtggcggtc     7740

tggaccacgc cggagagcgt cgaagcgggg gcggtgttcg ccgagatcgg cccgcgcatg     7800

gccgagttga gcggttcccg gctggccgcg cagcaacaga tggaaggcct cctggcgccg     7860

caccggccca aggagcccgc gtggttcctg gccaccgtcg gagtctcgcc cgaccaccag     7920

ggcaagggtc tgggcagcgc cgtcgtgctc cccggagtgg aggcggccga gcgcgccggg     7980

gtgcccgcct tcctggagac ctccgcgccc cgcaacctcc ccttctacga gcggctcggc     8040

ttcaccgtca ccgccgacgt cgaggtgccc gaaggaccgc gcacctggtg catgacccgc     8100

aagcccggtg cctgaacgcg ttaagtcgac aatcaacctc tggattacaa aatttgtgaa     8160

agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta     8220

atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa     8280

tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg     8340

tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc     8400

ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc     8460

cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg     8520

gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg     8580

acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg     8640

ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc     8700

ctttgggccg cctccccgcg tcgactttaa gaccaatgac ttacaaggca gctgtagatc     8760

ttagccactt tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac     8820

aagatctgct ttttgcttgt actgggtctc tctggttaga ccagatctga gcctgggagc     8880

tctctggcta actagggaac ccactgctta agcctcaata aagcttgcct tgagtgcttc     8940

aagtagtgtg tgcccgtctg ttgtgtgact ctggtaacta gagatccctc agaccctttt     9000

agtcagtgtg gaaaatctct agcagggccc gtttaaaccc gctgatcagc ctcgactgtg     9060

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     9120

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     9180

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     9240

gacaatagca ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc     9300

agctggggct ctagggggta tccccacgcg ccctgtagcg gcgcattaag cgcggcgggt     9360

gtggtggtta cgcgcagcgt gaccgctaca cttgccagcg ccctagcgcc cgctcctttc     9420

gctttcttcc cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg     9480

gggctccctt tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat     9540

tagggtgatg gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg     9600

ttggagtcca cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaaccct     9660

atctcggtct attcttttga tttataaggg attttgccga tttcggccta ttggttaaaa     9720

aatgagctga tttaacaaaa atttaacgcg aattaattct gtggaatgtg tgtcagttag     9780

ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg catctcaatt     9840

agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     9900

tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc ccgcccctaa     9960

ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt atttatgcag    10020

aggccgaggc cgcctctgcc tctgagctat tccagaagta gtgaggaggc ttttttggag    10080

gcctaggctt ttgcaaaaag ctcccgggag cttgtatatc cattttcgga tctgatcagc    10140

acgtgttgac aattaatcat cggcatagta tatcggcata gtataatacg acaaggtgag    10200

gaactaaacc atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc    10260

cggagcggtc gagttctgga ccgaccggct cgggttctcc cgggacttcg tggaggacga    10320

cttcgccggt gtggtccggg acgacgtgac cctgttcatc agcgcggtcc aggaccaggt    10380

ggtgccggac aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga    10440

gtggtcggag gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca tgaccgagat    10500

cggcgagcag ccgtgggggc gggagttcgc cctgcgcgac ccggccggca actgcgtgca    10560

cttcgtggcc gaggagcagg actgacacgt gctacgagat ttcgattcca ccgccgcctt    10620

ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga tcctccagcg    10680

cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag cttataatgg    10740

ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc    10800

tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac cgtcgacctc    10860

tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct    10920

cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg    10980

agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct    11040

gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg    11100

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc    11160

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg    11220

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct    11280

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca    11340

gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct    11400

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc    11460

gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt    11520

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc    11580

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc    11640

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg    11700

gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc    11760

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag    11820

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga    11880

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat    11940

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag    12000

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat    12060

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc    12120

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat    12180

accgcgagac ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag    12240

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg    12300

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc    12360

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca    12420

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg    12480

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc    12540

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta    12600

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc    12660

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg    12720

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc    12780

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc    12840

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat    12900

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag    12960

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc    13020

ccgaaaagtg ccacctgac                                                 13039


<210>  24
<211>  13813
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBK744 plasmid

<400>  24
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgtttttca agcggaaacg ctagttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgagaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggggccggc ccggatccgg     8520

cgcaacaaac ttctctctgc tgaaacaagc cggagatgtc gaagagaatc ctggaccgat     8580

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     8640

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     8700

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     8760

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     8820

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     8880

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     8940

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     9000

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     9060

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     9120

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     9180

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     9240

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaaag     9300

cggccgcgtc gacaatcaac ctctggatta caaaatttgt gaaagattga ctggtattct     9360

taactatgtt gctcctttta cgctatgtgg atacgctgct ttaatgcctt tgtatcatgc     9420

tattgcttcc cgtatggctt tcattttctc ctccttgtat aaatcctggt tgctgtctct     9480

ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg gtgtgcactg tgtttgctga     9540

cgcaaccccc actggttggg gcattgccac cacctgtcag ctcctttccg ggactttcgc     9600

tttccccctc cctattgcca cggcggaact catcgccgcc tgccttgccc gctgctggac     9660

aggggctcgg ctgttgggca ctgacaattc cgtggtgttg tcggggaagc tgacgtcctt     9720

tccatggctg ctcgcctgtg ttgccacctg gattctgcgc gggacgtcct tctgctacgt     9780

cccttcggcc ctcaatccag cggaccttcc ttcccgcggc ctgctgccgg ctctgcggcc     9840

tcttccgcgt cttcgccttc gccctcagac gagtcggatc tccctttggg ccgcctcccc     9900

gcctggaatt cgagctcggt acctttaaga ccaatgactt acaaggcagc tgtagatctt     9960

agccactttt taaaagaaaa ggggggactg gaagggctaa ttcactccca acgaagacaa    10020

gatctgcttt ttgcttgtac tgggtctctc tggttagacc agatctgagc ctgggagctc    10080

tctggctaac tagggaaccc actgcttaag cctcaataaa gcttgccttg agtgcttcaa    10140

gtagtgtgtg cccgtctgtt gtgtgactct ggtaactaga gatccctcag acccttttag    10200

tcagtgtgga aaatctctag cagtagtagt tcatgtcatc ttattattca gtatttataa    10260

cttgcaaaga aatgaatatc agagagtgag aggaacttgt ttattgcagc ttataatggt    10320

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct    10380

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggctcta gctatcccgc    10440

ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg    10500

gctgactaat tttttttatt tatgcagagg ccgaggccgc ctcggcctct gagctattcc    10560

agaagtagtg aggaggcttt tttggaggcc tagggacgta cccaattcgc cctatagtga    10620

gtcgtattac gcgcgctcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg    10680

cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga    10740

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc    10800

gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac    10860

acttgccagc gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt    10920

cgccggcttt ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc    10980

tttacggcac ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc    11040

gccctgatag acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact    11100

cttgttccaa actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg    11160

gattttgccg atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc    11220

gaattttaac aaaatattaa cgcttacaat ttaggtgccg gccatgaccg agatcggcga    11280

gcagccgtgg gggcgggagt tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt    11340

ggccgaggag caggactgac acgtgctacg agatttcgat tccaccgccg ccttctatga    11400

aaggttgggc ttcggaatcg ttttccggga cgccggctgg atgatcctcc agcgcgggga    11460

tctcatgctg gagttcttcg cccaccccaa cttgtttatt gcagcttata atggttacaa    11520

ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg    11580

tggtttgtcc aaactcatca atgtatctta tcatgtctgt ataccgtcga cctctagcta    11640

gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat    11700

tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag    11760

ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg    11820

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc    11880

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc    11940

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa    12000

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt    12060

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg    12120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg    12180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag    12240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc    12300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa    12360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg    12420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc    12480

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac    12540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg    12600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt    12660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt    12720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa    12780

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga    12840

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tccccgtcgt    12900

gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa tgataccgcg    12960

agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg gaagggccga    13020

gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt gttgccggga    13080

agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca ttgctacagg    13140

catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt cccaacgatc    13200

aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc    13260

gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg cagcactgca    13320

taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg agtactcaac    13380

caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg    13440

ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa aacgttcttc    13500

ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt aacccactcg    13560

tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt gagcaaaaac    13620

aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt gaatactcat    13680

actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca tgagcggata    13740

catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat ttccccgaaa    13800

agtgccacct gac                                                       13813


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA1 cloned into pBK1026 and pBK1030

<400>  25
gacaggggga gccctataat                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA2 cloned into pBK1027 and pBK1031

<400>  26
tcaggagagc tactcggggt                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA3 cloned into pBK1028 and pBK1032

<400>  27
actgggatgt aagccatagc                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA4 cloned into pBK1029 and pBK1033

<400>  28
gttggagctt agaatgtgaa                                                   20


<210>  29
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1026 plasmid

<400>  29
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggacaggg ggagccctat aatgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgagaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  30
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1027 plasmid

<400>  30
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgtcaggag agctactcgg ggtgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgagaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  31
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1028 plasmid

<400>  31
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgactggga tgtaagccat agcgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgagaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  32
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1029plasmid

<400>  32
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggttggag cttagaatgt gaagttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgagaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  33
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBK1030 plasmid

<400>  33
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggacaggg ggagccctat aatgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgcgaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  34
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1031 plasmid

<400>  34
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgtcaggag agctactcgg ggtgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgcgaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  35
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1032 plasmid

<400>  35
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgactggga tgtaagccat agcgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgcgaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  36
<211>  14093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1033 plasmid

<400>  36
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggttggag cttagaatgt gaagttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatcctggac tcccggatga acactaagta cgacgagaat gacaagctga tccgggaagt     6240

gaaagtgatc accctgaagt ccaagctggt gtccgatttc cggaaggatt tccagtttta     6300

caaagtgcgc gagatcaaca actaccacca cgcccacgac gcctacctga acgccgtcgt     6360

gggaaccgcc ctgatcaaaa agtaccctaa gctggaaagc gagttcgtgt acggcgacta     6420

caaggtgtac gacgtgcgga agatgatcgc caagagcgag caggaaatcg gcaaggctac     6480

cgccaagtac ttcttctaca gcaacatcat gaactttttc aagaccgaga ttaccctggc     6540

caacggcgag atccggaagc ggcctctgat cgagacaaac ggcgaaaccg gggagatcgt     6600

gtgggataag ggccgggatt ttgccaccgt gcggaaagtg ctgagcatgc cccaagtgaa     6660

tatcgtgaaa aagaccgagg tgcagacagg cggcttcagc aaagagtcta tcctgcccaa     6720

gaggaacagc gataagctga tcgccagaaa gaaggactgg gaccctaaga agtacggcgg     6780

cttcgacagc cccaccgtgg cctattctgt gctggtggtg gccaaagtgg aaaagggcaa     6840

gtccaagaaa ctgaagagtg tgaaagagct gctggggatc accatcatgg aaagaagcag     6900

cttcgagaag aatcccatcg actttctgga agccaagggc tacaaagaag tgaaaaagga     6960

cctgatcatc aagctgccta agtactccct gttcgagctg gaaaacggcc ggaagagaat     7020

gctggcctct gccggcgaac tgcagaaggg aaacgaactg gccctgccct ccaaatatgt     7080

gaacttcctg tacctggcca gccactatga gaagctgaag ggctcccccg aggataatga     7140

gcagaaacag ctgtttgtgg aacagcacaa gcactacctg gacgagatca tcgagcagat     7200

cagcgagttc tccaagagag tgatcctggc cgacgctaat ctggacaaag tgctgtccgc     7260

ctacaacaag caccgggata agcccatcag agagcaggcc gagaatatca tccacctgtt     7320

taccctgacc aatctgggag cccctgccgc cttcaagtac tttgacacca ccatcgaccg     7380

gaagaggtac accagcacca aagaggtgct ggacgccacc ctgatccacc agagcatcac     7440

cggcctgtac gagacacgga tcgacctgtc tcagctggga ggcgacaaaa ggccggcggc     7500

cacgaaaaag gccggacagg ccaaaaagaa aaagctcgag ggcggaggcg ggagcggatc     7560

cccctcccgg ctccagatgt tcttcgctaa taaccacgac caggaatttg accctccaaa     7620

ggtttaccca cctgtcccag ctgagaagag gaagcccatc cgggtgctgt ctctctttga     7680

tggaatcgct acagggctcc tggtgctgaa ggacttgggc attcaggtgg accgctacat     7740

tgcctcggag gtgtgtgagg actccatcac ggtgggcatg gtgcggcacc aggggaagat     7800

catgtacgtc ggggacgtcc gcagcgtcac acagaagcat atccaggagt ggggcccatt     7860

cgatctggtg attgggggca gtccctgcaa tgacctctcc atcgtcaacc ctgctcgcaa     7920

gggcctctac gagggcactg gccggctctt ctttgagttc taccgcctcc tgcatgatgc     7980

gcggcccaag gagggagatg atcgcccctt cttctggctc tttgcgaatg tggtggccat     8040

gggcgttagt gacaagaggg acatctcgcg atttctcgag tccaaccctg tgatgattga     8100

tgccaaagaa gtgtcagctg cacacagggc ccgctacttc tggggtaacc ttcccggtat     8160

gaacaggccg ttggcatcca ctgtgaatga taagctggag ctgcaggagt gtctggagca     8220

tggcaggata gccaagttca gcaaagtgag gaccattact acgaggtcaa actccataaa     8280

gcagggcaaa gaccagcatt ttcctgtgtt catgaatgag aaagaggaca tcttatggtg     8340

cactgaaatg gaaagggtat ttggtttccc agtccactat actgacgtgt ccaacatgag     8400

ccgcttggcg aggcagagac tgctgggccg gtcatggagc gtgccagtca tccgccacct     8460

cttcgctccg ctgaaggagt attttgcgtg tgtgtccggc cggcccggat ccggcgcaac     8520

aaacttctct ctgctgaaac aagccggaga tgtcgaagag aatcctggac cgaccgagta     8580

caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc agggccgtac gcaccctcgc     8640

cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc gatccggacc gccacatcga     8700

gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc gggctcgaca tcggcaaggt     8760

gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc acgccggaga gcgtcgaagc     8820

gggggcggtg ttcgccgaga tcggcccgcg catggccgag ttgagcggtt cccggctggc     8880

cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg cccaaggagc ccgcgtggtt     8940

cctggccacc gtcggagtct cgcccgacca ccagggcaag ggtctgggca gcgccgtcgt     9000

gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc gccttcctgg agacctccgc     9060

gccccgcaac ctccccttct acgagcggct cggcttcacc gtcaccgccg acgtcgaggt     9120

gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc ggtgcctgaa cgcgttaagt     9180

cgacaatcaa cctctggatt acaaaatttg tgaaagattg actggtattc ttaactatgt     9240

tgctcctttt acgctatgtg gatacgctgc tttaatgcct ttgtatcatg ctattgcttc     9300

ccgtatggct ttcattttct cctccttgta taaatcctgg ttgctgtctc tttatgagga     9360

gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact gtgtttgctg acgcaacccc     9420

cactggttgg ggcattgcca ccacctgtca gctcctttcc gggactttcg ctttccccct     9480

ccctattgcc acggcggaac tcatcgccgc ctgccttgcc cgctgctgga caggggctcg     9540

gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa tcatcgtcct ttccttggct     9600

gctcgcctgt gttgccacct ggattctgcg cgggacgtcc ttctgctacg tcccttcggc     9660

cctcaatcca gcggaccttc cttcccgcgg cctgctgccg gctctgcggc ctcttccgcg     9720

tcttcgcctt cgccctcaga cgagtcggat ctccctttgg gccgcctccc cgcgtcgact     9780

ttaagaccaa tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg     9840

ggactggaag ggctaattca ctcccaacga agacaagatc tgctttttgc ttgtactggg     9900

tctctctggt tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg     9960

cttaagcctc aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt    10020

gactctggta actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagg    10080

gcccgtttaa acccgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt    10140

ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta    10200

ataaaatgag gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg    10260

ggtggggcag gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggatgc    10320

ggtgggctct atggcttctg aggcggaaag aaccagctgg ggctctaggg ggtatcccca    10380

cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc    10440

tacacttgcc agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac    10500

gttcgccggc tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag    10560

tgctttacgg cacctcgacc ccaaaaaact tgattagggt gatggttcac gtagtgggcc    10620

atcgccctga tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg    10680

actcttgttc caaactggaa caacactcaa ccctatctcg gtctattctt ttgatttata    10740

agggattttg ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa    10800

cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg gaaagtcccc aggctcccca    10860

gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccaggtg tggaaagtcc    10920

ccaggctccc cagcaggcag aagtatgcaa agcatgcatc tcaattagtc agcaaccata    10980

gtcccgcccc taactccgcc catcccgccc ctaactccgc ccagttccgc ccattctccg    11040

ccccatggct gactaatttt ttttatttat gcagaggccg aggccgcctc tgcctctgag    11100

ctattccaga agtagtgagg aggctttttt ggaggcctag gcttttgcaa aaagctcccg    11160

ggagcttgta tatccatttt cggatctgat cagcacgtgt tgacaattaa tcatcggcat    11220

agtatatcgg catagtataa tacgacaagg tgaggaacta aaccatggcc aagttgacca    11280

gtgccgttcc ggtgctcacc gcgcgcgacg tcgccggagc ggtcgagttc tggaccgacc    11340

ggctcgggtt ctcccgggac ttcgtggagg acgacttcgc cggtgtggtc cgggacgacg    11400

tgaccctgtt catcagcgcg gtccaggacc aggtggtgcc ggacaacacc ctggcctggg    11460

tgtgggtgcg cggcctggac gagctgtacg ccgagtggtc ggaggtcgtg tccacgaact    11520

tccgggacgc ctccgggccg gccatgaccg agatcggcga gcagccgtgg gggcgggagt    11580

tcgccctgcg cgacccggcc ggcaactgcg tgcacttcgt ggccgaggag caggactgac    11640

acgtgctacg agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg    11700

ttttccggga cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg    11760

cccaccccaa cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa    11820

atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca    11880

atgtatctta tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt    11940

catagctgtt tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg    12000

gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt    12060

tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg    12120

gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg    12180

actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa    12240

tacggttatc cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc    12300

aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc    12360

ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat    12420

aaagatacca ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc    12480

cgcttaccgg atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct    12540

cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg    12600

aaccccccgt tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc    12660

cggtaagaca cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga    12720

ggtatgtagg cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa    12780

gaacagtatt tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta    12840

gctcttgatc cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc    12900

agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg    12960

acgctcagtg gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga    13020

tcttcaccta gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg    13080

agtaaacttg gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct    13140

gtctatttcg ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg    13200

agggcttacc atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc    13260

cagatttatc agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa    13320

ctttatccgc ctccatccag tctattaatt gttgccggga agctagagta agtagttcgc    13380

cagttaatag tttgcgcaac gttgttgcca ttgctacagg catcgtggtg tcacgctcgt    13440

cgtttggtat ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc    13500

ccatgttgtg caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt    13560

tggccgcagt gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc    13620

catccgtaag atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt    13680

gtatgcggcg accgagttgc tcttgcccgg cgtcaatacg ggataatacc gcgccacata    13740

gcagaacttt aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga    13800

tcttaccgct gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag    13860

catcttttac tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa    13920

aaaagggaat aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatatt    13980

attgaagcat ttatcagggt tattgtctca tgagcggata catatttgaa tgtatttaga    14040

aaaataaaca aataggggtt ccgcgcacat ttccccgaaa agtgccacct gac           14093


<210>  37
<211>  5208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - SpCas9 VRER sequence linked with DNMT3A

<400>  37
atggactata aggaccacga cggagactac aaggatcatg atattgatta caaagacgat       60

gacgataaga tggccccaaa gaagaagcgg aaggtcggta tccacggagt cccagcagcc      120

gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc      180

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      240

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      300

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      360

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      420

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      480

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      540

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      600

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      660

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      720

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      780

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggcaacctg      840

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      900

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      960

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg     1020

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg     1080

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1140

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1200

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1260

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1320

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1380

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1440

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1500

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1560

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1620

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1680

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1740

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1800

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1860

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1920

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1980

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     2040

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     2100

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2160

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2220

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2280

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2340

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2400

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2460

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2520

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2580

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggacgctatc     2640

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2700

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2760

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2820

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2880

gtggaaaccc ggcagatcac aaagcacgtg gcacagatac tagattcccg aatgaatacg     2940

aaatacgacg agaacgataa gctgattcgg gaagtcaaag taatcacttt aaagtcaaaa     3000

ttggtgtcgg acttcagaaa ggattttcaa ttctataaag ttagggagat aaataactac     3060

caccatgcgc acgacgctta tcttaatgcc gtcgtaggga ccgcactcat taagaaatac     3120

ccgaagctag aaagtgagtt tgtgtatggt gattacaaag tttatgacgt ccgtaagatg     3180

atcgcgaaaa gcgaacagga gataggcaag gctacagcca aatacttctt ttattctaac     3240

attatgaatt tctttaagac ggaaatcact ctggcaaacg gagagatacg caaacgacct     3300

ttaattgaaa ccaatgggga gacaggtgaa atcgtatggg ataagggccg ggacttcgcg     3360

acggtgagaa aagttttgtc catgccccaa gtcaacatag taaagaaaac tgaggtgcag     3420

accggagggt tttcaaagga atcgattctt ccaaaaagga atagtgataa gctcatcgct     3480

cgtaaaaagg actgggaccc gaaaaagtac ggtggcttcg tgagccctac agttgcctat     3540

tctgtcctag tagtggcaaa agttgagaag ggaaaatcca agaaactgaa gtcagtcaaa     3600

gaattattgg ggataacgat tatggagcgc tcgtcttttg aaaagaaccc catcgacttc     3660

cttgaggcga aaggttacaa ggaagtaaaa aaggatctca taattaaact accaaagtat     3720

agtctgtttg agttagaaaa tggccgaaaa cggatgttgg ctagcgccag agagcttcaa     3780

aaggggaacg aactcgcact accgtctaaa tacgtgaatt tcctgtattt agcgtcccat     3840

tacgagaagt tgaaaggttc acctgaagat aacgaacaga agcaactttt tgttgagcag     3900

cacaaacatt atctcgacga aatcatagag caaatttcgg aattcagtaa gagagtcatc     3960

ctagctgatg ccaatctgga caaagtatta agcgcataca acaagcacag ggataaaccc     4020

atacgtgagc aggcggaaaa tattatccat ttgtttactc ttaccaacct cggcgctcca     4080

gccgcattca agtattttga cacaacgata gatcgcaaag agtacagatc taccaaggag     4140

gtgctagacg cgacactgat tcaccaatcc atcacgggat tatatgaaac tcggatagat     4200

ttgtcacagc ttgggggtga cggatccccc aagaagaaga ggaaagtcct cgagggcgga     4260

ggcgggagcg gatccccctc ccggctccag atgttcttcg ctaataacca cgaccaggaa     4320

tttgaccctc caaaggttta cccacctgtc ccagctgaga agaggaagcc catccgggtg     4380

ctgtctctct ttgatggaat cgctacaggg ctcctggtgc tgaaggactt gggcattcag     4440

gtggaccgct acattgcctc ggaggtgtgt gaggactcca tcacggtggg catggtgcgg     4500

caccagggga agatcatgta cgtcggggac gtccgcagcg tcacacagaa gcatatccag     4560

gagtggggcc cattcgatct ggtgattggg ggcagtccct gcaatgacct ctccatcgtc     4620

aaccctgctc gcaagggcct ctacgagggc actggccggc tcttctttga gttctaccgc     4680

ctcctgcatg atgcgcggcc caaggaggga gatgatcgcc ccttcttctg gctctttgag     4740

aatgtggtgg ccatgggcgt tagtgacaag agggacatct cgcgatttct cgagtccaac     4800

cctgtgatga ttgatgccaa agaagtgtca gctgcacaca gggcccgcta cttctggggt     4860

aaccttcccg gtatgaacag gccgttggca tccactgtga atgataagct ggagctgcag     4920

gagtgtctgg agcatggcag gatagccaag ttcagcaaag tgaggaccat tactacgagg     4980

tcaaactcca taaagcaggg caaagaccag cattttcctg tgttcatgaa tgagaaagag     5040

gacatcttat ggtgcactga aatggaaagg gtatttggtt tcccagtcca ctatactgac     5100

gtgtccaaca tgagccgctt ggcgaggcag agactgctgg gccggtcatg gagcgtgcca     5160

gtcatccgcc acctcttcgc tccgctgaag gagtattttg cgtgtgtg                  5208


<210>  38
<211>  1688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VRER- DNMT3A

<400>  38

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
            740                 745                 750         


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
        755                 760                 765             


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
    770                 775                 780                 


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
785                 790                 795                 800 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
                805                 810                 815     


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
            820                 825                 830         


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
        835                 840                 845             


Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp 
    850                 855                 860                 


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
865                 870                 875                 880 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
                885                 890                 895     


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
            900                 905                 910         


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
        915                 920                 925             


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
    930                 935                 940                 


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
945                 950                 955                 960 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
                965                 970                 975     


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
            980                 985                 990         


Ile Asn Asn Tyr His His Ala His  Asp Ala Tyr Leu Asn  Ala Val Val 
        995                 1000                 1005             


Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
    1010                 1015                 1020             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1025                 1030                 1035             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1040                 1045                 1050             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1055                 1060                 1065             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1070                 1075                 1080             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1085                 1090                 1095             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1100                 1105                 1110             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1115                 1120                 1125             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1130                 1135                 1140             


Lys Tyr  Gly Gly Phe Val Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1145                 1150                 1155             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1160                 1165                 1170             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1175                 1180                 1185             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1190                 1195                 1200             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1205                 1210                 1215             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Arg Glu 
    1220                 1225                 1230             


Leu Gln  Lys Gly Asn Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln 
    1235                 1240                 1245             


Lys Gln  Leu Phe Val Glu Gln  His Lys His Tyr Leu  Asp Glu Ile 
    1250                 1255                 1260             


Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp 
    1265                 1270                 1275             


Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp 
    1280                 1285                 1290             


Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr 
    1295                 1300                 1305             


Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr 
    1310                 1315                 1320             


Thr Ile  Asp Arg Lys Glu Tyr  Arg Ser Thr Lys Glu  Val Leu Asp 
    1325                 1330                 1335             


Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg 
    1340                 1345                 1350             


Ile Asp  Leu Ser Gln Leu Gly  Gly Asp Gly Ser Pro  Lys Lys Lys 
    1355                 1360                 1365             


Val Leu  Glu Gly Gly Gly Gly  Ser Gly Ser Pro Ser  Arg Leu Gln 
    1370                 1375                 1380             


Met Phe  Phe Ala Asn Asn His  Asp Gln Glu Phe Asp  Pro Pro Lys 
    1385                 1390                 1395             


Val Tyr  Pro Pro Val Pro Ala  Glu Lys Arg Lys Pro  Ile Arg Val 
    1400                 1405                 1410             


Leu Ser  Leu Phe Asp Gly Ile  Ala Thr Gly Leu Leu  Val Leu Lys 
    1415                 1420                 1425             


Asp Leu  Gly Ile Gln Val Asp  Arg Tyr Ile Ala Ser  Glu Val Cys 
    1430                 1435                 1440             


Glu Asp  Ser Ile Thr Val Gly  Met Val Arg His Gln  Gly Lys Ile 
    1445                 1450                 1455             


Met Tyr  Val Gly Asp Val Arg  Ser Val Thr Gln Lys  His Ile Gln 
    1460                 1465                 1470             


Glu Trp  Gly Pro Phe Asp Leu  Val Ile Gly Gly Ser  Pro Cys Asn 
    1475                 1480                 1485             


Asp Leu  Ser Ile Val Asn Pro  Ala Arg Lys Gly Leu  Tyr Glu Gly 
    1490                 1495                 1500             


Thr Gly  Arg Leu Phe Phe Glu  Phe Tyr Arg Leu Leu  His Asp Ala 
    1505                 1510                 1515             


Arg Pro  Lys Glu Gly Asp Asp  Arg Pro Phe Phe Trp  Leu Phe Glu 
    1520                 1525                 1530             


Asn Val  Val Ala Met Gly Val  Ser Asp Lys Arg Asp  Ile Ser Arg 
    1535                 1540                 1545             


Phe Leu  Glu Ser Asn Pro Val  Met Ile Asp Ala Lys  Glu Val Ser 
    1550                 1555                 1560             


Ala Ala  His Arg Ala Arg Tyr  Phe Trp Gly Asn Leu  Pro Gly Met 
    1565                 1570                 1575             


Asn Arg  Pro Leu Ala Ser Thr  Val Asn Asp Lys Leu  Glu Leu Gln 
    1580                 1585                 1590             


Glu Cys  Leu Glu His Arg Ile  Ala Lys Phe Ser Lys  Val Arg Thr 
    1595                 1600                 1605             


Ile Thr  Thr Arg Ser Asn Ser  Ile Lys Gln Gly Lys  Asp Gln His 
    1610                 1615                 1620             


Phe Pro  Val Phe Met Asn Glu  Lys Glu Asp Ile Leu  Trp Cys Thr 
    1625                 1630                 1635             


Glu Met  Glu Arg Val Phe Gly  Phe Pro Val His Tyr  Thr Asp Val 
    1640                 1645                 1650             


Ser Asn  Met Ser Arg Leu Ala  Arg Gln Arg Leu Leu  Gly Arg Ser 
    1655                 1660                 1665             


Trp Ser  Val Pro Val Ile Arg  His Leu Phe Ala Pro  Leu Lys Glu 
    1670                 1675                 1680             


Tyr Phe  Ala Cys Val 
    1685             


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA1 cloned into pBK1105 and pBK1109 plasmids

<400>  39
gccctatccc tgggggaggg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gRNA2 cloned into pBK1106 and pBK1110 plasmids

<400>  40
tcgggcttgg ggagaggagg                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA3 cloned into pBK1107 and pBK1111 plasmids

<400>  41
ctctccccac cccaccttct                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA4 cloned into pBK1108 and pBK1112 plasmids

<400>  42
tgtgaaggga gaatgaggaa                                                   20


<210>  43
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1105 plasmid

<400>  43
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggccctat ccctggggga ggggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgagaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  44
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBK1106 plasmid

<400>  44
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgtcgggct tggggagagg agggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgagaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  45
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBK1107 plasmid

<400>  45
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgctctccc caccccacct tctgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgagaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  46
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1108 plasmid

<400>  46
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgtgtgaag ggagaatgag gaagttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgagaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  47
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBK1109 plasmid

<400>  47
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggccctat ccctggggga ggggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgcgaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  48
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1110 plasmid

<400>  48
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgtcgggct tggggagagg agggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgcgaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  49
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1111 plasmid

<400>  49
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgctctccc caccccacct tctgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgcgaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  50
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1112 plasmid

<400>  50
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccgtgtgaag ggagaatgag gaagttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgcgaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA1 cloned into pBK1426 and pBK1428 plasmids

<400>  51
gcggtactgc accaggcggc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - gRNA2 cloned into pBK1427 and pBK1429 plasmids

<400>  52
gggcgcggac atggaggacg                                                   20


<210>  53
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1426 plasmid

<400>  53
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggcggtac tgcaccaggc ggcgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgagaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  54
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1427 plasmid

<400>  54
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggggcgcg gacatggagg acggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgagaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  55
<211>  13327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1428 plasmid

<400>  55
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggcggtac tgcaccaggc ggcgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgcgaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacct                                                              13327


<210>  56
<211>  13330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1429 plasmid

<400>  56
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggggcgcg gacatggagg acggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat cccccaagaa     7500

gaagaggaaa gtcctcgagg gcggaggcgg gagcggatcc ccctcccggc tccagatgtt     7560

cttcgctaat aaccacgacc aggaatttga ccctccaaag gtttacccac ctgtcccagc     7620

tgagaagagg aagcccatcc gggtgctgtc tctctttgat ggaatcgcta cagggctcct     7680

ggtgctgaag gacttgggca ttcaggtgga ccgctacatt gcctcggagg tgtgtgagga     7740

ctccatcacg gtgggcatgg tgcggcacca ggggaagatc atgtacgtcg gggacgtccg     7800

cagcgtcaca cagaagcata tccaggagtg gggcccattc gatctggtga ttgggggcag     7860

tccctgcaat gacctctcca tcgtcaaccc tgctcgcaag ggcctctacg agggcactgg     7920

ccggctcttc tttgagttct accgcctcct gcatgatgcg cggcccaagg agggagatga     7980

tcgccccttc ttctggctct ttgcgaatgt ggtggccatg ggcgttagtg acaagaggga     8040

catctcgcga tttctcgagt ccaaccctgt gatgattgat gccaaagaag tgtcagctgc     8100

acacagggcc cgctacttct ggggtaacct tcccggtatg aacaggccgt tggcatccac     8160

tgtgaatgat aagctggagc tgcaggagtg tctggagcat ggcaggatag ccaagttcag     8220

caaagtgagg accattacta cgaggtcaaa ctccataaag cagggcaaag accagcattt     8280

tcctgtgttc atgaatgaga aagaggacat cttatggtgc actgaaatgg aaagggtatt     8340

tggtttccca gtccactata ctgacgtgtc caacatgagc cgcttggcga ggcagagact     8400

gctgggccgg tcatggagcg tgccagtcat ccgccacctc ttcgctccgc tgaaggagta     8460

ttttgcgtgt gtgtccggcc ggcccggatc cggcgcaaca aacttctctc tgctgaaaca     8520

agccggagat gtcgaagaga atcctggacc gaccgagtac aagcccacgg tgcgcctcgc     8580

cacccgcgac gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc     8640

cgccacgcgc cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga     8700

actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc     8760

cgcggtggcg gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat     8820

cggcccgcgc atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg     8880

cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggagtctc     8940

gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc     9000

cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta     9060

cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg     9120

gtgcatgacc cgcaagcccg gtgcctgaac gcgttaagtc gacaatcaac ctctggatta     9180

caaaatttgt gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg     9240

atacgctgct ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc     9300

ctccttgtat aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca     9360

acgtggcgtg gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac     9420

cacctgtcag ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact     9480

catcgccgcc tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc     9540

cgtggtgttg tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg     9600

gattctgcgc gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc     9660

ttcccgcggc ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac     9720

gagtcggatc tccctttggg ccgcctcccc gcgtcgactt taagaccaat gacttacaag     9780

gcagctgtag atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac     9840

tcccaacgaa gacaagatct gctttttgct tgtactgggt ctctctggtt agaccagatc     9900

tgagcctggg agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg     9960

ccttgagtgc ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc    10020

ctcagaccct tttagtcagt gtggaaaatc tctagcaggg cccgtttaaa cccgctgatc    10080

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc    10140

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc    10200

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg    10260

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga    10320

ggcggaaaga accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt    10380

aagcgcggcg ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc    10440

gcccgctcct ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca    10500

agctctaaat cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc    10560

caaaaaactt gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt    10620

tcgccctttg acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac    10680

aacactcaac cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc    10740

ctattggtta aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat    10800

gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc    10860

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga    10920

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc    10980

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt    11040

tttatttatg cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga    11100

ggcttttttg gaggcctagg cttttgcaaa aagctcccta ccgtcgacct ctagctagag    11160

cttggcgtaa tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc    11220

acacaacata cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta    11280

actcacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca    11340

gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc    11400

cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc    11460

tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat    11520

gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt    11580

ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg    11640

aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc    11700

tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt    11760

ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa    11820

gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta    11880

tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa    11940

caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa    12000

ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt    12060

cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt    12120

ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat    12180

cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat    12240

gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc    12300

aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc    12360

acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta    12420

gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga    12480

cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg    12540

cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc    12600

tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat    12660

cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag    12720

gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat    12780

cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa    12840

ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa    12900

gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga    12960

taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg    13020

gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc    13080

acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg    13140

aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact    13200

cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat    13260

atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt    13320

gccacctgac                                                           13330


<210>  57
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - MeCP2 Transcription Repression Domain (TRD)

<400>  57
atgtcggagg gtgtgcaggt gaaaagggtc ctggagaaaa gtcctgggaa gctccttgtc       60

aagatgcctt ttcaaacttc gccagggggc aaggctgagg ggggtggggc caccacatcc      120

acccaggtca tggtgatcaa acgccccggc aggaagcgaa aagctgaggc cgaccctcag      180

gccattccca agaaacgggg ccgaaagccg gggagtgtgg tggcagccgc tgccgccgag      240

gccaaaaaga aagccgtgaa ggagtcttct atccgatctg tgcaggagac agtactcccc      300

atcaagaagc gcaagacccg ggagtaa                                          327


<210>  58
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - MeCP2 Transcription Repression Domain (TRD)

<400>  58

Met Ser Glu Gly Val Gln Val Lys Arg Val Leu Glu Lys Ser Pro Gly 
1               5                   10                  15      


Lys Leu Leu Val Lys Met Pro Phe Gln Thr Ser Pro Gly Gly Lys Ala 
            20                  25                  30          


Glu Gly Gly Gly Ala Thr Thr Ser Thr Gln Val Met Val Ile Lys Arg 
        35                  40                  45              


Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys 
    50                  55                  60                  


Lys Arg Gly Arg Lys Pro Gly Ser Val Val Ala Ala Ala Ala Ala Glu 
65                  70                  75                  80  


Ala Lys Lys Lys Ala Val Lys Glu Ser Ser Ile Arg Ser Val Gln Glu 
                85                  90                  95      


Thr Val Leu Pro Ile Lys Lys Arg Lys Thr Arg Glu 
            100                 105             


<210>  59
<211>  12952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1531 plasmid

<400>  59
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggcggtac tgcaccaggc ggcgttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat ccccaaagaa     7500

gaaacggaag gtgggtggag gaagtggcgg gtcaggtggc tctagacgga cactggtgac     7560

cttcaaggat gtatttgtgg acttcaccag ggaggagtgg aagctgctgg acactgctca     7620

gcagatcgtg tacagaaatg tgatgctgga gaactataag aacctggttt ccttgggtta     7680

tcagcttact aagccagatg tgatcctccg gttggagaag ggagaagagc cctcgggagg     7740

tggttcggga ggtggttcgg agggtgtgca ggtgaaaagg gtcctggaga aaagtcctgg     7800

gaagctcctt gtcaagatgc cttttcaaac ttcgccaggg ggcaaggctg aggggggtgg     7860

ggccaccaca tccacccagg tcatggtgat caaacgcccc ggcaggaagc gaaaagctga     7920

ggccgaccct caggccattc ccaagaaacg gggccgaaag ccggggagtg tggtggcagc     7980

cgctgccgcc gaggccaaaa agaaagccgt gaaggagtct tctatccgat ctgtgcagga     8040

gacagtactc cccatcaaga agcgcaagac ccgggagggc gcgcccaaga agaagaggaa     8100

agtctccgga tccggcgcaa caaacttctc tctgctgaaa caagccggag atgtcgaaga     8160

gaatcctgga ccgaccgagt acaagcccac ggtgcgcctc gccacccgcg acgacgtccc     8220

cagggccgta cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc gccacaccgt     8280

cgatccggac cgccacatcg agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt     8340

cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac     8400

cacgccggag agcgtcgaag cgggggcggt gttcgccgag atcggcccgc gcatggccga     8460

gttgagcggt tcccggctgg ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg     8520

gcccaaggag cccgcgtggt tcctggccac cgtcggagtc tcgcccgacc accagggcaa     8580

gggtctgggc agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc     8640

cgccttcctg gagacctccg cgccccgcaa cctccccttc tacgagcggc tcggcttcac     8700

cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc     8760

cggtgcctga acgcgttaag tcgacaatca acctctggat tacaaaattt gtgaaagatt     8820

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     8880

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     8940

gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac     9000

tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc     9060

cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc     9120

ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa     9180

atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc     9240

cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc     9300

ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg     9360

ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt agatcttagc     9420

cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat     9480

ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct     9540

ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta     9600

gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca     9660

gtgtggaaaa tctctagcag ggcccgttta aacccgctga tcagcctcga ctgtgccttc     9720

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     9780

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     9840

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     9900

tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa gaaccagctg     9960

gggctctagg gggtatcccc acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt    10020

ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt    10080

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct    10140

ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg    10200

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga    10260

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc    10320

ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga    10380

gctgatttaa caaaaattta acgcgaatta attctgtgga atgtgtgtca gttagggtgt    10440

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca    10500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat    10560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg    10620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc    10680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta    10740

ggcttttgca aaaagctccc taccgtcgac ctctagctag agcttggcgt aatcatggtc    10800

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg    10860

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt    10920

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg    10980

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga    11040

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat    11100

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca    11160

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc    11220

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata    11280

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc    11340

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc    11400

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga    11460

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc    11520

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag    11580

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag    11640

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag    11700

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca    11760

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga    11820

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat    11880

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga    11940

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg    12000

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga    12060

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc    12120

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac    12180

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc    12240

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc    12300

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc    12360

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt    12420

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc    12480

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg    12540

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag    12600

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat    12660

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc    12720

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa    12780

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta    12840

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa    12900

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg ac            12952


<210>  60
<211>  12952
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1532 plasmid

<400>  60
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggggcgcg gacatggagg acggttttag agctagaaat agcaagttaa aataaggcta     2940

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct tttttgaatt cgctagctag     3000

gtcttgaaag gagtgggaat tggctccggt gcccgtcagt gggcagagcg cacatcgccc     3060

acagtccccg agaagttggg gggaggggtc ggcaattgat ccggtgccta gagaaggtgg     3120

cgcggggtaa actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg     3180

ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc     3240

gccagaacac aggaccggtg ccaccatgga ctataaggac cacgacggag actacaagga     3300

tcatgatatt gattacaaag acgatgacga taagatggcc ccaaagaaga agcggaaggt     3360

cggtatccac ggagtcccag cagccgacaa gaagtacagc atcggcctgg ccatcggcac     3420

caactctgtg ggctgggccg tgatcaccga cgagtacaag gtgcccagca agaaattcaa     3480

ggtgctgggc aacaccgacc ggcacagcat caagaagaac ctgatcggag ccctgctgtt     3540

cgacagcggc gaaacagccg aggccacccg gctgaagaga accgccagaa gaagatacac     3600

cagacggaag aaccggatct gctatctgca agagatcttc agcaacgaga tggccaaggt     3660

ggacgacagc ttcttccaca gactggaaga gtccttcctg gtggaagagg ataagaagca     3720

cgagcggcac cccatcttcg gcaacatcgt ggacgaggtg gcctaccacg agaagtaccc     3780

caccatctac cacctgagaa agaaactggt ggacagcacc gacaaggccg acctgcggct     3840

gatctatctg gccctggccc acatgatcaa gttccggggc cacttcctga tcgagggcga     3900

cctgaacccc gacaacagcg acgtggacaa gctgttcatc cagctggtgc agacctacaa     3960

ccagctgttc gaggaaaacc ccatcaacgc cagcggcgtg gacgccaagg ccatcctgtc     4020

tgccagactg agcaagagca gacggctgga aaatctgatc gcccagctgc ccggcgagaa     4080

gaagaatggc ctgttcggca acctgattgc cctgagcctg ggcctgaccc ccaacttcaa     4140

gagcaacttc gacctggccg aggatgccaa actgcagctg agcaaggaca cctacgacga     4200

cgacctggac aacctgctgg cccagatcgg cgaccagtac gccgacctgt ttctggccgc     4260

caagaacctg tccgacgcca tcctgctgag cgacatcctg agagtgaaca ccgagatcac     4320

caaggccccc ctgagcgcct ctatgatcaa gagatacgac gagcaccacc aggacctgac     4380

cctgctgaaa gctctcgtgc ggcagcagct gcctgagaag tacaaagaga ttttcttcga     4440

ccagagcaag aacggctacg ccggctacat tgacggcgga gccagccagg aagagttcta     4500

caagttcatc aagcccatcc tggaaaagat ggacggcacc gaggaactgc tcgtgaagct     4560

gaacagagag gacctgctgc ggaagcagcg gaccttcgac aacggcagca tcccccacca     4620

gatccacctg ggagagctgc acgccattct gcggcggcag gaagattttt acccattcct     4680

gaaggacaac cgggaaaaga tcgagaagat cctgaccttc cgcatcccct actacgtggg     4740

ccctctggcc aggggaaaca gcagattcgc ctggatgacc agaaagagcg aggaaaccat     4800

caccccctgg aacttcgagg aagtggtgga caagggcgct tccgcccaga gcttcatcga     4860

gcggatgacc aacttcgata agaacctgcc caacgagaag gtgctgccca agcacagcct     4920

gctgtacgag tacttcaccg tgtataacga gctgaccaaa gtgaaatacg tgaccgaggg     4980

aatgagaaag cccgccttcc tgagcggcga gcagaaaaag gccatcgtgg acctgctgtt     5040

caagaccaac cggaaagtga ccgtgaagca gctgaaagag gactacttca agaaaatcga     5100

gtgcttcgac tccgtggaaa tctccggcgt ggaagatcgg ttcaacgcct ccctgggcac     5160

ataccacgat ctgctgaaaa ttatcaagga caaggacttc ctggacaatg aggaaaacga     5220

ggacattctg gaagatatcg tgctgaccct gacactgttt gaggacagag agatgatcga     5280

ggaacggctg aaaacctatg cccacctgtt cgacgacaaa gtgatgaagc agctgaagcg     5340

gcggagatac accggctggg gcaggctgag ccggaagctg atcaacggca tccgggacaa     5400

gcagtccggc aagacaatcc tggatttcct gaagtccgac ggcttcgcca acagaaactt     5460

catgcagctg atccacgacg acagcctgac ctttaaagag gacatccaga aagcccaggt     5520

gtccggccag ggcgatagcc tgcacgagca cattgccaat ctggccggca gccccgccat     5580

taagaagggc atcctgcaga cagtgaaggt ggtggacgag ctcgtgaaag tgatgggccg     5640

gcacaagccc gagaacatcg tgatcgaaat ggccagagag aaccagacca cccagaaggg     5700

acagaagaac agccgcgaga gaatgaagcg gatcgaagag ggcatcaaag agctgggcag     5760

ccagatcctg aaagaacacc ccgtggaaaa cacccagctg cagaacgaga agctgtacct     5820

gtactacctg cagaatgggc gggatatgta cgtggaccag gaactggaca tcaaccggct     5880

gtccgactac gatgtggacg ctatcgtgcc tcagagcttt ctgaaggacg actccatcga     5940

caacaaggtg ctgaccagaa gcgacaagaa ccggggcaag agcgacaacg tgccctccga     6000

agaggtcgtg aagaagatga agaactactg gcggcagctg ctgaacgcca agctgattac     6060

ccagagaaag ttcgacaatc tgaccaaggc cgagagaggc ggcctgagcg aactggataa     6120

ggccggcttc atcaagagac agctggtgga aacccggcag atcacaaagc acgtggcaca     6180

gatactagat tcccgaatga atacgaaata cgacgagaac gataagctga ttcgggaagt     6240

caaagtaatc actttaaagt caaaattggt gtcggacttc agaaaggatt ttcaattcta     6300

taaagttagg gagataaata actaccacca tgcgcacgac gcttatctta atgccgtcgt     6360

agggaccgca ctcattaaga aatacccgaa gctagaaagt gagtttgtgt atggtgatta     6420

caaagtttat gacgtccgta agatgatcgc gaaaagcgaa caggagatag gcaaggctac     6480

agccaaatac ttcttttatt ctaacattat gaatttcttt aagacggaaa tcactctggc     6540

aaacggagag atacgcaaac gacctttaat tgaaaccaat ggggagacag gtgaaatcgt     6600

atgggataag ggccgggact tcgcgacggt gagaaaagtt ttgtccatgc cccaagtcaa     6660

catagtaaag aaaactgagg tgcagaccgg agggttttca aaggaatcga ttcttccaaa     6720

aaggaatagt gataagctca tcgctcgtaa aaaggactgg gacccgaaaa agtacggtgg     6780

cttcgtgagc cctacagttg cctattctgt cctagtagtg gcaaaagttg agaagggaaa     6840

atccaagaaa ctgaagtcag tcaaagaatt attggggata acgattatgg agcgctcgtc     6900

ttttgaaaag aaccccatcg acttccttga ggcgaaaggt tacaaggaag taaaaaagga     6960

tctcataatt aaactaccaa agtatagtct gtttgagtta gaaaatggcc gaaaacggat     7020

gttggctagc gccagagagc ttcaaaaggg gaacgaactc gcactaccgt ctaaatacgt     7080

gaatttcctg tatttagcgt cccattacga gaagttgaaa ggttcacctg aagataacga     7140

acagaagcaa ctttttgttg agcagcacaa acattatctc gacgaaatca tagagcaaat     7200

ttcggaattc agtaagagag tcatcctagc tgatgccaat ctggacaaag tattaagcgc     7260

atacaacaag cacagggata aacccatacg tgagcaggcg gaaaatatta tccatttgtt     7320

tactcttacc aacctcggcg ctccagccgc attcaagtat tttgacacaa cgatagatcg     7380

caaagagtac agatctacca aggaggtgct agacgcgaca ctgattcacc aatccatcac     7440

gggattatat gaaactcgga tagatttgtc acagcttggg ggtgacggat ccccaaagaa     7500

gaaacggaag gtgggtggag gaagtggcgg gtcaggtggc tctagacgga cactggtgac     7560

cttcaaggat gtatttgtgg acttcaccag ggaggagtgg aagctgctgg acactgctca     7620

gcagatcgtg tacagaaatg tgatgctgga gaactataag aacctggttt ccttgggtta     7680

tcagcttact aagccagatg tgatcctccg gttggagaag ggagaagagc cctcgggagg     7740

tggttcggga ggtggttcgg agggtgtgca ggtgaaaagg gtcctggaga aaagtcctgg     7800

gaagctcctt gtcaagatgc cttttcaaac ttcgccaggg ggcaaggctg aggggggtgg     7860

ggccaccaca tccacccagg tcatggtgat caaacgcccc ggcaggaagc gaaaagctga     7920

ggccgaccct caggccattc ccaagaaacg gggccgaaag ccggggagtg tggtggcagc     7980

cgctgccgcc gaggccaaaa agaaagccgt gaaggagtct tctatccgat ctgtgcagga     8040

gacagtactc cccatcaaga agcgcaagac ccgggagggc gcgcccaaga agaagaggaa     8100

agtctccgga tccggcgcaa caaacttctc tctgctgaaa caagccggag atgtcgaaga     8160

gaatcctgga ccgaccgagt acaagcccac ggtgcgcctc gccacccgcg acgacgtccc     8220

cagggccgta cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc gccacaccgt     8280

cgatccggac cgccacatcg agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt     8340

cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac     8400

cacgccggag agcgtcgaag cgggggcggt gttcgccgag atcggcccgc gcatggccga     8460

gttgagcggt tcccggctgg ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg     8520

gcccaaggag cccgcgtggt tcctggccac cgtcggagtc tcgcccgacc accagggcaa     8580

gggtctgggc agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc     8640

cgccttcctg gagacctccg cgccccgcaa cctccccttc tacgagcggc tcggcttcac     8700

cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc     8760

cggtgcctga acgcgttaag tcgacaatca acctctggat tacaaaattt gtgaaagatt     8820

gactggtatt cttaactatg ttgctccttt tacgctatgt ggatacgctg ctttaatgcc     8880

tttgtatcat gctattgctt cccgtatggc tttcattttc tcctccttgt ataaatcctg     8940

gttgctgtct ctttatgagg agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac     9000

tgtgtttgct gacgcaaccc ccactggttg gggcattgcc accacctgtc agctcctttc     9060

cgggactttc gctttccccc tccctattgc cacggcggaa ctcatcgccg cctgccttgc     9120

ccgctgctgg acaggggctc ggctgttggg cactgacaat tccgtggtgt tgtcggggaa     9180

atcatcgtcc tttccttggc tgctcgcctg tgttgccacc tggattctgc gcgggacgtc     9240

cttctgctac gtcccttcgg ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc     9300

ggctctgcgg cctcttccgc gtcttcgcct tcgccctcag acgagtcgga tctccctttg     9360

ggccgcctcc ccgcgtcgac tttaagacca atgacttaca aggcagctgt agatcttagc     9420

cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg aagacaagat     9480

ctgctttttg cttgtactgg gtctctctgg ttagaccaga tctgagcctg ggagctctct     9540

ggctaactag ggaacccact gcttaagcct caataaagct tgccttgagt gcttcaagta     9600

gtgtgtgccc gtctgttgtg tgactctggt aactagagat ccctcagacc cttttagtca     9660

gtgtggaaaa tctctagcag ggcccgttta aacccgctga tcagcctcga ctgtgccttc     9720

tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc tggaaggtgc     9780

cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc tgagtaggtg     9840

tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt gggaagacaa     9900

tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa gaaccagctg     9960

gggctctagg gggtatcccc acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt    10020

ggttacgcgc agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt    10080

cttcccttcc tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct    10140

ccctttaggg ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg    10200

tgatggttca cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga    10260

gtccacgttc tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc    10320

ggtctattct tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga    10380

gctgatttaa caaaaattta acgcgaatta attctgtgga atgtgtgtca gttagggtgt    10440

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca    10500

gcaaccaggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat    10560

ctcaattagt cagcaaccat agtcccgccc ctaactccgc ccatcccgcc cctaactccg    10620

cccagttccg cccattctcc gccccatggc tgactaattt tttttattta tgcagaggcc    10680

gaggccgcct ctgcctctga gctattccag aagtagtgag gaggcttttt tggaggccta    10740

ggcttttgca aaaagctccc taccgtcgac ctctagctag agcttggcgt aatcatggtc    10800

atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca tacgagccgg    10860

aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat taattgcgtt    10920

gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt aatgaatcgg    10980

ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct cgctcactga    11040

ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa aggcggtaat    11100

acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa aaggccagca    11160

aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc tccgcccccc    11220

tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga caggactata    11280

aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc    11340

gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt ctcatagctc    11400

acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga    11460

accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg agtccaaccc    11520

ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta gcagagcgag    11580

gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct acactagaag    11640

aacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa gagttggtag    11700

ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt gcaagcagca    11760

gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta cggggtctga    11820

cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat caaaaaggat    11880

cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa gtatatatga    11940

gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct cagcgatctg    12000

tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta cgatacggga    12060

gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct caccggctcc    12120

agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg gtcctgcaac    12180

tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa gtagttcgcc    12240

agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc    12300

gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta catgatcccc    12360

catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca gaagtaagtt    12420

ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta ctgtcatgcc    12480

atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct gagaatagtg    12540

tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg cgccacatag    12600

cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac tctcaaggat    12660

cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact gatcttcagc    12720

atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa    12780

aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt ttcaatatta    12840

ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa    12900

aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg ac            12952


<210>  61
<211>  12951
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - pBK1536 plasmid

<400>  61
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcgttgac      240

attgattatt gactagttat taatagtaat caattacggg gtcattagtt catagcccat      300

atatggagtt ccgcgttaca taacttacgg taaatggccc gcctggctga ccgcccaacg      360

acccccgccc attgacgtca ataatgacgt atgttcccat agtaacgcca atagggactt      420

tccattgacg tcaatgggtg gagtatttac ggtaaactgc ccacttggca gtacatcaag      480

tgtatcatat gccaagtacg ccccctattg acgtcaatga cggtaaatgg cccgcctggc      540

attatgccca gtacatgacc ttatgggact ttcctacttg gcagtacatc tacgtattag      600

tcatcgctat taccatggtg atgcggtttt ggcagtacat caatgggcgt ggatagcggt      660

ttgactcacg gggatttcca agtctccacc ccattgacgt caatgggagt ttgttttggc      720

accaaaatca acgggacttt ccaaaatgtc gtaacaactc cgccccattg acgcaaatgg      780

gcggtaggcg tgtacggtgg gaggtctata taagcagcgc gttttgcctg tactgggtct      840

ctctggttag accagatctg agcctgggag ctctctggct aactagggaa cccactgctt      900

aagcctcaat aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac      960

tctggtaact agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagtggc     1020

gcccgaacag ggacttgaaa gcgaaaggga aaccagagga gctctctcga cgcaggactc     1080

ggcttgctga agcgcgcacg gcaagaggcg aggggcggcg actggtgagt acgccaaaaa     1140

ttttgactag cggaggctag aaggagagag atgggtgcga gagcgtcagt attaagcggg     1200

ggagaattag atcgcgatgg gaaaaaattc ggttaaggcc agggggaaag aaaaaatata     1260

aattaaaaca tatagtatgg gcaagcaggg agctagaacg attcgcagtt aatcctggcc     1320

tgttagaaac atcagaaggc tgtagacaaa tactgggaca gctacaacca tcccttcaga     1380

caggatcaga agaacttaga tcattatata atacagtagc aaccctctat tgtgtgcatc     1440

aaaggataga gataaaagac accaaggaag ctttagacaa gatagaggaa gagcaaaaca     1500

aaagtaagac caccgcacag caagcggccg ctgatcttca gacctggagg aggagatatg     1560

agggacaatt ggagaagtga attatataaa tataaagtag taaaaattga accattagga     1620

gtagcaccca ccaaggcaaa gagaagagtg gtgcagagag aaaaaagagc agtgggaata     1680

ggagctttgt tccttgggtt cttgggagca gcaggaagca ctatgggcgc agcgtcaatg     1740

acgctgacgg tacaggccag acaattattg tctggtatag tgcagcagca gaacaatttg     1800

ctgagggcta ttgaggcgca acagcatctg ttgcaactca cagtctgggg catcaagcag     1860

ctccaggcaa gaatcctggc tgtggaaaga tacctaaagg atcaacagct cctggggatt     1920

tggggttgct ctggaaaact catttgcacc actgctgtgc cttggaatgc tagttggagt     1980

aataaatctc tggaacagat ttggaatcac acgacctgga tggagtggga cagagaaatt     2040

aacaattaca caagcttaat acactcctta attgaagaat cgcaaaacca gcaagaaaag     2100

aatgaacaag aattattgga attagataaa tgggcaagtt tgtggaattg gtttaacata     2160

acaaattggc tgtggtatat aaaattattc ataatgatag taggaggctt ggtaggttta     2220

agaatagttt ttgctgtact ttctatagtg aatagagtta ggcagggata ttcaccatta     2280

tcgtttcaga cccacctccc aaccccgagg ggacccgaca ggcccgaagg aatagaagaa     2340

gaaggtggag agagagacag agacagatcc attcgattag tgaacggatc ggcactgcgt     2400

gcgccaattc tgcagacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     2460

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     2520

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     2580

agatccagtt tggttaatta atgggcggga cgttaacggg gcggaacggt accgagggcc     2640

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataatta     2700

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     2760

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     2820

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     2880

ccggagacgt gtacacgtct ctgttttaga gctagaaata gcaagttaaa ataaggctag     2940

tccgttatca acttgaaaaa gtggcaccga gtcggtgctt ttttgaattc gctagctagg     3000

tcttgaaagg agtgggaatt ggctccggtg cccgtcagtg ggcagagcgc acatcgccca     3060

cagtccccga gaagttgggg ggaggggtcg gcaattgatc cggtgcctag agaaggtggc     3120

gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc gagggtgggg     3180

gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg     3240

ccagaacaca ggaccggtgc caccatggac tataaggacc acgacggaga ctacaaggat     3300

catgatattg attacaaaga cgatgacgat aagatggccc caaagaagaa gcggaaggtc     3360

ggtatccacg gagtcccagc agccgacaag aagtacagca tcggcctggc catcggcacc     3420

aactctgtgg gctgggccgt gatcaccgac gagtacaagg tgcccagcaa gaaattcaag     3480

gtgctgggca acaccgaccg gcacagcatc aagaagaacc tgatcggagc cctgctgttc     3540

gacagcggcg aaacagccga ggccacccgg ctgaagagaa ccgccagaag aagatacacc     3600

agacggaaga accggatctg ctatctgcaa gagatcttca gcaacgagat ggccaaggtg     3660

gacgacagct tcttccacag actggaagag tccttcctgg tggaagagga taagaagcac     3720

gagcggcacc ccatcttcgg caacatcgtg gacgaggtgg cctaccacga gaagtacccc     3780

accatctacc acctgagaaa gaaactggtg gacagcaccg acaaggccga cctgcggctg     3840

atctatctgg ccctggccca catgatcaag ttccggggcc acttcctgat cgagggcgac     3900

ctgaaccccg acaacagcga cgtggacaag ctgttcatcc agctggtgca gacctacaac     3960

cagctgttcg aggaaaaccc catcaacgcc agcggcgtgg acgccaaggc catcctgtct     4020

gccagactga gcaagagcag acggctggaa aatctgatcg cccagctgcc cggcgagaag     4080

aagaatggcc tgttcggcaa cctgattgcc ctgagcctgg gcctgacccc caacttcaag     4140

agcaacttcg acctggccga ggatgccaaa ctgcagctga gcaaggacac ctacgacgac     4200

gacctggaca acctgctggc ccagatcggc gaccagtacg ccgacctgtt tctggccgcc     4260

aagaacctgt ccgacgccat cctgctgagc gacatcctga gagtgaacac cgagatcacc     4320

aaggcccccc tgagcgcctc tatgatcaag agatacgacg agcaccacca ggacctgacc     4380

ctgctgaaag ctctcgtgcg gcagcagctg cctgagaagt acaaagagat tttcttcgac     4440

cagagcaaga acggctacgc cggctacatt gacggcggag ccagccagga agagttctac     4500

aagttcatca agcccatcct ggaaaagatg gacggcaccg aggaactgct cgtgaagctg     4560

aacagagagg acctgctgcg gaagcagcgg accttcgaca acggcagcat cccccaccag     4620

atccacctgg gagagctgca cgccattctg cggcggcagg aagattttta cccattcctg     4680

aaggacaacc gggaaaagat cgagaagatc ctgaccttcc gcatccccta ctacgtgggc     4740

cctctggcca ggggaaacag cagattcgcc tggatgacca gaaagagcga ggaaaccatc     4800

accccctgga acttcgagga agtggtggac aagggcgctt ccgcccagag cttcatcgag     4860

cggatgacca acttcgataa gaacctgccc aacgagaagg tgctgcccaa gcacagcctg     4920

ctgtacgagt acttcaccgt gtataacgag ctgaccaaag tgaaatacgt gaccgaggga     4980

atgagaaagc ccgccttcct gagcggcgag cagaaaaagg ccatcgtgga cctgctgttc     5040

aagaccaacc ggaaagtgac cgtgaagcag ctgaaagagg actacttcaa gaaaatcgag     5100

tgcttcgact ccgtggaaat ctccggcgtg gaagatcggt tcaacgcctc cctgggcaca     5160

taccacgatc tgctgaaaat tatcaaggac aaggacttcc tggacaatga ggaaaacgag     5220

gacattctgg aagatatcgt gctgaccctg acactgtttg aggacagaga gatgatcgag     5280

gaacggctga aaacctatgc ccacctgttc gacgacaaag tgatgaagca gctgaagcgg     5340

cggagataca ccggctgggg caggctgagc cggaagctga tcaacggcat ccgggacaag     5400

cagtccggca agacaatcct ggatttcctg aagtccgacg gcttcgccaa cagaaacttc     5460

atgcagctga tccacgacga cagcctgacc tttaaagagg acatccagaa agcccaggtg     5520

tccggccagg gcgatagcct gcacgagcac attgccaatc tggccggcag ccccgccatt     5580

aagaagggca tcctgcagac agtgaaggtg gtggacgagc tcgtgaaagt gatgggccgg     5640

cacaagcccg agaacatcgt gatcgaaatg gccagagaga accagaccac ccagaaggga     5700

cagaagaaca gccgcgagag aatgaagcgg atcgaagagg gcatcaaaga gctgggcagc     5760

cagatcctga aagaacaccc cgtggaaaac acccagctgc agaacgagaa gctgtacctg     5820

tactacctgc agaatgggcg ggatatgtac gtggaccagg aactggacat caaccggctg     5880

tccgactacg atgtggacgc tatcgtgcct cagagctttc tgaaggacga ctccatcgac     5940

aacaaggtgc tgaccagaag cgacaagaac cggggcaaga gcgacaacgt gccctccgaa     6000

gaggtcgtga agaagatgaa gaactactgg cggcagctgc tgaacgccaa gctgattacc     6060

cagagaaagt tcgacaatct gaccaaggcc gagagaggcg gcctgagcga actggataag     6120

gccggcttca tcaagagaca gctggtggaa acccggcaga tcacaaagca cgtggcacag     6180

atactagatt cccgaatgaa tacgaaatac gacgagaacg ataagctgat tcgggaagtc     6240

aaagtaatca ctttaaagtc aaaattggtg tcggacttca gaaaggattt tcaattctat     6300

aaagttaggg agataaataa ctaccaccat gcgcacgacg cttatcttaa tgccgtcgta     6360

gggaccgcac tcattaagaa atacccgaag ctagaaagtg agtttgtgta tggtgattac     6420

aaagtttatg acgtccgtaa gatgatcgcg aaaagcgaac aggagatagg caaggctaca     6480

gccaaatact tcttttattc taacattatg aatttcttta agacggaaat cactctggca     6540

aacggagaga tacgcaaacg acctttaatt gaaaccaatg gggagacagg tgaaatcgta     6600

tgggataagg gccgggactt cgcgacggtg agaaaagttt tgtccatgcc ccaagtcaac     6660

atagtaaaga aaactgaggt gcagaccgga gggttttcaa aggaatcgat tcttccaaaa     6720

aggaatagtg ataagctcat cgctcgtaaa aaggactggg acccgaaaaa gtacggtggc     6780

ttcgtgagcc ctacagttgc ctattctgtc ctagtagtgg caaaagttga gaagggaaaa     6840

tccaagaaac tgaagtcagt caaagaatta ttggggataa cgattatgga gcgctcgtct     6900

tttgaaaaga accccatcga cttccttgag gcgaaaggtt acaaggaagt aaaaaaggat     6960

ctcataatta aactaccaaa gtatagtctg tttgagttag aaaatggccg aaaacggatg     7020

ttggctagcg ccagagagct tcaaaagggg aacgaactcg cactaccgtc taaatacgtg     7080

aatttcctgt atttagcgtc ccattacgag aagttgaaag gttcacctga agataacgaa     7140

cagaagcaac tttttgttga gcagcacaaa cattatctcg acgaaatcat agagcaaatt     7200

tcggaattca gtaagagagt catcctagct gatgccaatc tggacaaagt attaagcgca     7260

tacaacaagc acagggataa acccatacgt gagcaggcgg aaaatattat ccatttgttt     7320

actcttacca acctcggcgc tccagccgca ttcaagtatt ttgacacaac gatagatcgc     7380

aaagagtaca gatctaccaa ggaggtgcta gacgcgacac tgattcacca atccatcacg     7440

ggattatatg aaactcggat agatttgtca cagcttgggg gtgacggatc cccaaagaag     7500

aaacggaagg tgggtggagg aagtggcggg tcaggtggct ctagacggac actggtgacc     7560

ttcaaggatg tatttgtgga cttcaccagg gaggagtgga agctgctgga cactgctcag     7620

cagatcgtgt acagaaatgt gatgctggag aactataaga acctggtttc cttgggttat     7680

cagcttacta agccagatgt gatcctccgg ttggagaagg gagaagagcc ctcgggaggt     7740

ggttcgggag gtggttcgga gggtgtgcag gtgaaaaggg tcctggagaa aagtcctggg     7800

aagctccttg tcaagatgcc ttttcaaact tcgccagggg gcaaggctga ggggggtggg     7860

gccaccacat ccacccaggt catggtgatc aaacgccccg gcaggaagcg aaaagctgag     7920

gccgaccctc aggccattcc caagaaacgg ggccgaaagc cggggagtgt ggtggcagcc     7980

gctgccgccg aggccaaaaa gaaagccgtg aaggagtctt ctatccgatc tgtgcaggag     8040

acagtactcc ccatcaagaa gcgcaagacc cgggagggcg cgcccaagaa gaagaggaaa     8100

gtctccggat ccggcgcaac aaacttctct ctgctgaaac aagccggaga tgtcgaagag     8160

aatcctggac cgaccgagta caagcccacg gtgcgcctcg ccacccgcga cgacgtcccc     8220

agggccgtac gcaccctcgc cgccgcgttc gccgactacc ccgccacgcg ccacaccgtc     8280

gatccggacc gccacatcga gcgggtcacc gagctgcaag aactcttcct cacgcgcgtc     8340

gggctcgaca tcggcaaggt gtgggtcgcg gacgacggcg ccgcggtggc ggtctggacc     8400

acgccggaga gcgtcgaagc gggggcggtg ttcgccgaga tcggcccgcg catggccgag     8460

ttgagcggtt cccggctggc cgcgcagcaa cagatggaag gcctcctggc gccgcaccgg     8520

cccaaggagc ccgcgtggtt cctggccacc gtcggagtct cgcccgacca ccagggcaag     8580

ggtctgggca gcgccgtcgt gctccccgga gtggaggcgg ccgagcgcgc cggggtgccc     8640

gccttcctgg agacctccgc gccccgcaac ctccccttct acgagcggct cggcttcacc     8700

gtcaccgccg acgtcgaggt gcccgaagga ccgcgcacct ggtgcatgac ccgcaagccc     8760

ggtgcctgaa cgcgttaagt cgacaatcaa cctctggatt acaaaatttg tgaaagattg     8820

actggtattc ttaactatgt tgctcctttt acgctatgtg gatacgctgc tttaatgcct     8880

ttgtatcatg ctattgcttc ccgtatggct ttcattttct cctccttgta taaatcctgg     8940

ttgctgtctc tttatgagga gttgtggccc gttgtcaggc aacgtggcgt ggtgtgcact     9000

gtgtttgctg acgcaacccc cactggttgg ggcattgcca ccacctgtca gctcctttcc     9060

gggactttcg ctttccccct ccctattgcc acggcggaac tcatcgccgc ctgccttgcc     9120

cgctgctgga caggggctcg gctgttgggc actgacaatt ccgtggtgtt gtcggggaaa     9180

tcatcgtcct ttccttggct gctcgcctgt gttgccacct ggattctgcg cgggacgtcc     9240

ttctgctacg tcccttcggc cctcaatcca gcggaccttc cttcccgcgg cctgctgccg     9300

gctctgcggc ctcttccgcg tcttcgcctt cgccctcaga cgagtcggat ctccctttgg     9360

gccgcctccc cgcgtcgact ttaagaccaa tgacttacaa ggcagctgta gatcttagcc     9420

actttttaaa agaaaagggg ggactggaag ggctaattca ctcccaacga agacaagatc     9480

tgctttttgc ttgtactggg tctctctggt tagaccagat ctgagcctgg gagctctctg     9540

gctaactagg gaacccactg cttaagcctc aataaagctt gccttgagtg cttcaagtag     9600

tgtgtgcccg tctgttgtgt gactctggta actagagatc cctcagaccc ttttagtcag     9660

tgtggaaaat ctctagcagg gcccgtttaa acccgctgat cagcctcgac tgtgccttct     9720

agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct ggaaggtgcc     9780

actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct gagtaggtgt     9840

cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg ggaagacaat     9900

agcaggcatg ctggggatgc ggtgggctct atggcttctg aggcggaaag aaccagctgg     9960

ggctctaggg ggtatcccca cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg    10020

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc    10080

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc    10140

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt    10200

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag    10260

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg    10320

gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag    10380

ctgatttaac aaaaatttaa cgcgaattaa ttctgtggaa tgtgtgtcag ttagggtgtg    10440

gaaagtcccc aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag    10500

caaccaggtg tggaaagtcc ccaggctccc cagcaggcag aagtatgcaa agcatgcatc    10560

tcaattagtc agcaaccata gtcccgcccc taactccgcc catcccgccc ctaactccgc    10620

ccagttccgc ccattctccg ccccatggct gactaatttt ttttatttat gcagaggccg    10680

aggccgcctc tgcctctgag ctattccaga agtagtgagg aggctttttt ggaggcctag    10740

gcttttgcaa aaagctccct accgtcgacc tctagctaga gcttggcgta atcatggtca    10800

tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga    10860

agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg    10920

cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc    10980

caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac    11040

tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata    11100

cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa    11160

aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct    11220

gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa    11280

agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg    11340

cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca    11400

cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa    11460

ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg    11520

gtaagacacg acttatcgcc actggcagca gccactggta acaggattag cagagcgagg    11580

tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga    11640

acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc    11700

tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag    11760

attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac    11820

gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc    11880

ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag    11940

taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt    12000

ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag    12060

ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca    12120

gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact    12180

ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca    12240

gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg    12300

tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc    12360

atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg    12420

gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca    12480

tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt    12540

atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc    12600

agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc    12660

ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca    12720

tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa    12780

aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat    12840

tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa    12900

aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga c             12951


<210>  62
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic - KRAB-MeCP2 Repressor

<400>  62
atgcggacac tggtgacctt caaggatgta tttgtggact tcaccaggga ggagtggaag       60

ctgctggaca ctgctcagca gatcgtgtac agaaatgtga tgctggagaa ctataagaac      120

ctggtttcct tgggttatca gcttactaag ccagatgtga tcctccggtt ggagaaggga      180

gaagagccct cgggaggtgg ttcgggaggt ggttcggagg gtgtgcaggt gaaaagggtc      240

ctggagaaaa gtcctgggaa gctccttgtc aagatgcctt ttcaaacttc gccagggggc      300

aaggctgagg ggggtggggc caccacatcc acccaggtca tggtgatcaa acgccccggc      360

aggaagcgaa aagctgaggc cgaccctcag gccattccca agaaacgggg ccgaaagccg      420

gggagtgtgg tggcagccgc tgccgccgag gccaaaaaga aagccgtgaa ggagtcttct      480

atccgatctg tgcaggagac agtactcccc atcaagaagc gcaagacccg ggagtaa         537


<210>  63
<211>  178
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic - KRAB-MeCP2 Repressor Protein ORF

<400>  63

Met Arg Thr Leu Val Thr Phe Lys Asp Val Phe Val Asp Phe Thr Arg 
1               5                   10                  15      


Glu Glu Trp Lys Leu Leu Asp Thr Ala Gln Gln Ile Val Tyr Arg Asn 
            20                  25                  30          


Val Met Leu Glu Asn Tyr Lys Asn Leu Val Ser Leu Gly Tyr Gln Leu 
        35                  40                  45              


Thr Lys Pro Asp Val Ile Leu Arg Leu Glu Lys Gly Glu Glu Pro Ser 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Ser Glu Gly Val Gln Val Lys Arg Val 
65                  70                  75                  80  


Leu Glu Lys Ser Pro Gly Lys Leu Leu Val Lys Met Pro Phe Gln Thr 
                85                  90                  95      


Ser Pro Gly Gly Lys Ala Glu Gly Gly Gly Ala Thr Thr Ser Thr Gln 
            100                 105                 110         


Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys Ala Glu Ala Asp 
        115                 120                 125             


Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro Gly Ser Val Val 
    130                 135                 140                 


Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val Lys Glu Ser Ser 
145                 150                 155                 160 


Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile Lys Lys Arg Lys Thr 
                165                 170                 175     


Arg Glu 
        


<210>  64
<211>  1053
<212>  PRT
<213>  Staphylococcus aureus

<400>  64

Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210>  65
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  65

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Asp Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Leu Asn Ser Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Ala Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Ile Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Leu Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


