                         SEQUENCE LISTING

<110>   Immune-Onc Therapeutics, Inc.
 
<120>  Novel ANTI-LILRB2 ANTIBODIES AND DERIVATIVE PRODUCTS

<130>  066564-8014WO01

<160>  139   

<170>  PatentIn version 3.5

<210>  1
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-VH

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  2
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-VL

<400>  2

Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln Arg 
1               5                   10                  15      


Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Val 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Gln Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  3
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-1-VH

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Glu Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  4
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-1-VL

<400>  4

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-2-VH

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Gln Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  6
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-2-VL

<400>  6

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  7
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-3-VH

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  8
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-3-VL

<400>  8

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  9
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-4-VH

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  10
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-4-VL

<400>  10

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Glu Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  11
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-5-VH

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  12
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-5-VL

<400>  12

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  13
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-6-VH

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  14
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-6-VL

<400>  14

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Gln Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  15
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-7-VH

<400>  15

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-7-VL

<400>  16

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gln Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  17
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-8-VH

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  18
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-8-VL

<400>  18

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  19
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-9-VH

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Phe Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  20
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-9-VL

<400>  20

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  21
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-10-VH

<400>  21

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  22
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-10-VL

<400>  22

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Phe Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  23
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-11-VH

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  24
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-11-VL

<400>  24

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  25
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-12-VH

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  26
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-12-VL

<400>  26

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  27
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-14-VH

<400>  27

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  28
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-14-VL

<400>  28

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  29
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-15-VH

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Glu Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  30
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-15-VL

<400>  30

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  31
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-16-VH

<400>  31

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  32
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-16-VL

<400>  32

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  33
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-17-VH

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Ser Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  34
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-17-VL

<400>  34

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  35
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-18-VH

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Gly Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  36
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-18-VL

<400>  36

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  37
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-20-VH

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  38
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-20-VL

<400>  38

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  39
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-21-VH

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  40
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-21-VL

<400>  40

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  41
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-22-VH

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  42
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-22-VL

<400>  42

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Tyr Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  43
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-23-VH

<400>  43

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  44
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-23-VL

<400>  44

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  45
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-24-VH

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  46
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-24-VL

<400>  46

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Glu Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  47
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-25-VH

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  48
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-25-VL

<400>  48

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Thr Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  49
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-26-VH

<400>  49

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  50
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-26-VL

<400>  50

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  51
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-28-VH

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  52
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-28-VL

<400>  52

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  53
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-30-VH

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Ser Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  54
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-30-VL

<400>  54

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  55
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-31-VH

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Ser Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  56
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-31-VL

<400>  56

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  57
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-32-VH

<400>  57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Glu Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  58
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-32-VL

<400>  58

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  59
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-34-VH

<400>  59

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  60
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-34-VL

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu 
            20                  25                  30          


Asn Val Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Thr Trp Asp Glu Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  61
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-35-VH

<400>  61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  62
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-35-VL

<400>  62

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu 
            20                  25                  30          


Asn Val Val Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Thr Ile Ser Arg Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Ala Thr Trp Asp Glu Ser 
                85                  90                  95      


Leu Ser Gly Pro Val Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  63
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-36-VH

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  64
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-36-VL

<400>  64

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gln Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Gln Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  65
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-37-VH

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  66
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-37-VL

<400>  66

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gln Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Ala Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Gln Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  67
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-38-VH

<400>  67

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  68
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-38-VL

<400>  68

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asn Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  69
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-39-VH

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  70
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-39-VL

<400>  70

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  71
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-40-VH

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  72
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-40-VL

<400>  72

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asn Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  73
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-41-VH

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  74
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-41-VL

<400>  74

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Gly Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  75
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-42-VH

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  76
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-42-VL

<400>  76

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Asn Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  77
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-43-VH

<400>  77

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  78
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-43-VL

<400>  78

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Ala 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  79
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-44-VH

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  80
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-44-VL

<400>  80

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Gly 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  81
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-45-VH

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  82
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-45-VL

<400>  82

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Lys 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  83
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-46-VH

<400>  83

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  84
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-46-VL

<400>  84

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Thr 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  85
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-48-VH

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  86
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-48-VL

<400>  86

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  87
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-49-VH

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  88
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-49-VL

<400>  88

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Phe Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  89
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-50-VH

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  90
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-50-VL

<400>  90

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  91
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-51-VH

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  92
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-51-VL

<400>  92

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  93
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-52-VH

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  94
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-52-VL

<400>  94

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  95
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-53-VH

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  96
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-53-VL

<400>  96

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Tyr 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  97
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-54-VH

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  98
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-54-VL

<400>  98

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Thr Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  99
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-55-VH

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  100
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-55-VL

<400>  100

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  101
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-56-VH

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Gln Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  102
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-56-VL

<400>  102

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  103
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-57-VH

<400>  103

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Glu Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  104
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-57-VL

<400>  104

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  105
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-58-VH

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg His Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  106
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-58-VL

<400>  106

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  107
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-59-VH

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Pro Ser Ser Ser Trp Tyr Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  108
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-59-VL

<400>  108

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  109
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-60-VH

<400>  109

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Glu Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  110
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-60-VL

<400>  110

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  111
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-61-VH

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp His Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  112
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-61-VL

<400>  112

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  113
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-62-VH

<400>  113

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Pro Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  114
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-62-VL

<400>  114

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  115
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-63-VH

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Thr Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Arg Tyr Ser Ser Ser Trp Gln Ser Pro Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Thr Val Ser Val Ser Ser 
        115                 120                 125 


<210>  116
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B2-19-63-VL

<400>  116

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Glu Ala Pro Arg Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Glu Asn 
            20                  25                  30          


Val Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Glu Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Glu Ser Leu 
                85                  90                  95      


Ser Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  117
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 S228P

<400>  117

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  118
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 S228P delK

<400>  118

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  119
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG4 R409K

<400>  119

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  120
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lambda

<400>  120

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  121
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  kappa

<400>  121

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  122
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2-19-HC NA

<400>  122
caggtgcagc tggtgcagtc cggcggcgga ctggtgaagc ctggcggaag cctgaggctg       60

tcctgcgccg ctagcggctt caccttcagc aatgcctgga tgagctgggt gaggcaggcc      120

cccggcaagg gactggagtg ggtgggaagg atcaagtcca agaccgatgg cggcaccacc      180

gattacgccg ctcctgtgaa gggccggttc accatctcca gggatgattc caagaacacc      240

ctgtacctgc agatgaactc cctgaagacc gaggataccg ccgtgtacta ctgtaccacc      300

gaccggtact cctccagctg gtactccccc gccttcgata tctggggcca gggcaccacc      360

gtgtccgtgt ccagcgctag cacaaagggc ccctccgtgt ttcctctcgc tccctgcagc      420

cggagcacat ccgagagcac cgctgctctg ggctgtctcg tgaaggacta cttccctgaa      480

cccgtcaccg tcagctggaa tagcggcgcc ctgacatccg gcgtccacac attccccgct      540

gtcctgcaga gcagcggcct gtacagcctg agctccgtgg tcaccgtgcc tagcagcagc      600

ctgggaacaa agacctacac ctgcaacgtg gaccataagc cctccaacac caaggtggac      660

aagcgggtgg aatccaagta tggacccccc tgtcctcctt gccctgctcc tgaatttctc      720

ggaggcccct ccgtcttcct gtttcccccc aagcccaagg acaccctgat gatctcccgg      780

acacccgaag tcacctgcgt cgtggtggat gtcagccagg aagatcccga ggtgcagttc      840

aactggtacg tggacggagt ggaggtgcat aacgccaaaa ccaagcccag ggaagagcag      900

ttcaacagca cctatcgggt cgtgtccgtg ctcaccgtcc tgcatcagga ttggctcaac      960

ggcaaggagt acaagtgcaa ggtgtccaac aagggcctgc cctcctccat cgagaagacc     1020

atctccaagg ctaagggcca acctcgggag ccccaagtgt ataccctccc tcccagccag     1080

gaggagatga ccaagaatca agtgagcctg acctgcctcg tgaagggatt ttacccctcc     1140

gacatcgctg tggaatggga aagcaatggc caacctgaga acaactacaa gaccacaccc     1200

cccgtgctgg actccgatgg ctccttcttc ctgtacagca ggctgaccgt ggacaaatcc     1260

cggtggcaag agggaaacgt gttcagctgc tccgtgatgc acgaggctct ccacaaccac     1320

tacacccaga agagcctctc cctgagcctc ggcaag                               1356


<210>  123
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2-19-LC NA

<400>  123
cagcctgtgc tgacccagcc ccccagcgtg tccgaggctc ctagacagcg ggtgaccatc       60

tcctgcagcg gctccagcag caatatcggc aacaatgtgg tgaactggta tcagcagctg      120

cccggcaagg cccccaagct gctgatctat tacgatgatc tgctgccctc cggcgtgtcc      180

gacaggttca gcggcagcaa gagcggcacc tccgctagcc tggccatctc cggcctgcag      240

tccgaggacg aggctgatta ttactgtgct acctgggacg actccctgaa tggccctgtg      300

ttcggcggcg gcaccaagct gaccgtgctg gggcagccaa aagcggcgcc aagcgtcaca      360

ctgtttcctc cctcctctga agaactgcag gcaaataagg caactctggt ctgtctgatt      420

agcgacttct acccaggcgc tgtgaccgtc gcatggaagg ccgatagctc ccccgtgaaa      480

gccggggtcg agaccacaac tccttccaag cagtctaaca acaagtacgc cgcttctagt      540

tatctgagtc tgacacccga acagtggaag tcccaccggt catatagctg ccaggtcact      600

cacgaaggct ctactgtgga aaaaactgtc gccccaaccg aatgttca                   648


<210>  124
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2-19-12-HC

<400>  124
gaagtgcagc tggtggaatc tggcggtggc ctggtcaagc caggcggttc ccttcgcctg       60

tcttgcgccg cttcgggctt caccttctcc aacgcatgga tgtcttgggt taggcaggca      120

cctggcaagg ggctggaatg ggtcgggcgc attaaatcta aaactgacgg cggaacaact      180

gactacgctg cgcctgtcaa ggggagattc accatctccc gggacgattc caaaaacaca      240

ctttacttac aaatgaactc tctcaagacc gaggataccg ctgtgtacta ctgcacaaca      300

gataggtact catcgtcatg gtactcccct gccttcgata tttggggcca ggggacaact      360

gtatccgtgt caagcgcctc aaccaagggc cccagcgtgt tccctttggc cccatgctcc      420

cggagcactt ctgaaagcac ggccgcactc ggatgcctgg tcaaggacta cttccccgaa      480

cccgtgaccg ttagctggaa ttctggagcc cttacaagcg gagttcatac cttcccggcg      540

gtactgcaat cgagcggact gtatagcctg agttctgtgg tgactgttcc aagctccagt      600

ctcggcacca aaacttatac ttgtaatgtt gatcataaac cttctaacac caaggtagac      660

aagagagttg agtccaaata cggaccacct tgtccgccgt gccctgcacc ggagttcctc      720

ggtggcccaa gcgtgtttct gttccctcct aaaccaaagg acaccctgat gatctctcgg      780

actcctgaag tgacatgcgt ggtagttgat gtcagccagg aagaccccga ggtccagttc      840

aactggtacg tggatggcgt cgaggtgcac aatgcaaaga ccaagcccag agaggagcaa      900

tttaatagca cataccgggt tgtctctgtg ctgaccgtcc tacaccaaga ttggctgaac      960

gggaaggagt ataagtgcaa agtgtctaac aagggcctgc ctagctctat tgagaagaca     1020

ataagcaaag ctaagggcca gccaagggag ccccaggtct acaccctccc accatcgcaa     1080

gaagaaatga ctaagaacca ggtcagcctg acctgtcttg tgaaggggtt ctaccctagt     1140

gacatcgccg tcgaatggga aagtaacggg cagcccgaga ataactacaa gactacgcca     1200

cctgttctgg actctgatgg gtccttcttc ctttattcaa gactgacagt ggataaatct     1260

agatggcagg aaggcaacgt tttttcatgc tctgtgatgc acgaggctct ccacaatcac     1320

tacacacaaa agtcccttag cctgtctctt ggcaaa                               1356


<210>  125
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2-19-12-LC NA

<400>  125
cagtctgtgc tcacacaacc gccaagcgtt tcggaagcgc ctcgtcaacg ggtgaccatc       60

agctgctccg gctcctcatc caatattggc gagaatgtcg tcaactggta tcaacaacta      120

cccggcaagg cacctaagct gctgatttac tacgaggacc tccttccttc cggtgtcagc      180

gatagattca gtggctctaa gtccggaaca tctgcctctc tggccatcag cggactgcag      240

agcgaggacg aggcagacta ttactgcgca acttgggatg agagcctgaa cgggccagtg      300

ttcggcggtg gcaccaagct taccgttctg gggcagccaa aagccgctcc ttctgtcacc      360

ctgtttccgc cttctagcga ggaactgcaa gcaaataagg ccaccctagt ttgtcttata      420

agcgacttct accctggagc agtgacagtt gcttggaagg ccgatagttc tcctgtcaaa      480

gctggcgttg agactactac accaagcaag cagtctaata ataaatatgc agctagttcc      540

tacctctctt taactccgga gcagtggaaa tcccatcgga gctactcttg tcaagttacc      600

cacgaaggct ctactgtcga gaagactgtc gctcctaccg aatgttca                   648


<210>  126
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2-19-16-HC NA

<400>  126
gaggtgcagc tcgtggagag tggaggcggc ctcgtgaagc caggcggatc cctgagactg       60

agctgcgctg caagtggctt cacattctcc aatgcatgga tgagctgggt taggcaggcc      120

cctggcaagg gactggaatg ggttggacgg attaaaagca agaccgatac cgggacaacc      180

gactacgctg ccccggttaa gggcagattt actatctcta gggacgatag caagaacaca      240

ctgtatctcc aaatgaatag tcttaagacc gaggataccg ccgtctacta ctgcaccacc      300

gataggtact caagttcatg gtacagcccg gcatttgaca tctggggaca ggggaccacc      360

gtgtcggtgt caagcgcctc tactaagggc ccttctgtgt ttccactggc accctgttcg      420

cggagcacat ctgaatctac tgctgccctc ggatgtctgg tcaaggacta cttccctgag      480

cccgttaccg ttagctggaa tagcggggct ctgacaagcg gagtgcacac gttcccggcc      540

gtccttcaat cttctggcct ttattcttta tcgtcggtgg ttactgtccc aagtagttct      600

ctcggcacta agacttacac ctgtaacgtg gaccacaagc ccagtaacac taaggtggac      660

aagagagtcg agtccaaata cggcccacca tgcccacctt gtcccgctcc tgaattcctt      720

ggaggtccat ctgtcttcct gtttccacct aagcccaagg ataccctcat gatctctaga      780

actcctgaag tcacttgcgt ggttgtggac gtcagccagg aagatcctga ggtccagttc      840

aactggtacg tggatggagt ggaggtgcac aacgccaaga ccaaaccacg cgaggaacaa      900

tttaattcca cttatcgggt tgtatctgtt ctaaccgtct tgcatcaaga ttggctgaac      960

ggcaaggagt ataagtgcaa ggtatccaat aagggcctgc cctcttccat tgaaaagacc     1020

atttctaagg ctaagggaca gcctagggag ccccaggttt acactcttcc acctagccaa     1080

gaagagatga ccaagaacca ggtcagcctc acctgcctcg ttaaagggtt ctacccttcc     1140

gacatcgccg ttgaatggga gtcaaacggg cagcctgaga acaattacaa gaccacacca     1200

cctgttctgg attccgacgg atccttcttc ctttactccc gcttaactgt agacaagagt     1260

cggtggcagg aaggtaacgt gttctcctgt agtgttatgc atgaggccct gcataaccac     1320

tacactcaaa aatcgctttc gctgtctctg ggcaaa                               1356


<210>  127
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2-19-16-LC NA

<400>  127
cagagcgtgc taacacaacc tccatctgtg tcggaagcac cgaggcaacg agtcactata       60

agttgcagtg gcagctctag taacatcggc gagaatgtgg ttaactggta tcagcaactc      120

cccggcaagg ctcccaagct gctgatctac tacgaggacc tgctcccatc cggggttagc      180

gatagattca gcggaagtaa atccggcaca agcgcttccc tggccatttc cggcctccaa      240

agcgaggatg aggccgacta ttactgcgcc acctgggacg agagcctttc tggtcctgtc      300

ttcggcggag gaactaagct caccgtgttg ggtcagccta aagccgcacc atccgtgacc      360

ctcttcccgc cgtctagcga ggaactgcaa gccaataagg ccaccctggt ctgcctaatt      420

agcgacttct accctggagc agtgaccgtc gcctggaagg cagacagtag tcccgtgaaa      480

gctggcgtgg agacaacaac accgtcaaaa cagtcaaaca ataaatacgc cgcaagttca      540

tacttatcct tgaccccgga gcagtggaag tcccatcggt cctactcttg tcaagtgaca      600

cacgaaggct ctaccgttga aaagactgtg gctcctaccg aatgtagc                   648


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 128

<400>  128

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  129
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8alpha transmembrane domain

<400>  129

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  130
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding CD8alpha transmembrane domain

<400>  130
atctacatct gggctccact ggcaggaacc tgtggcgtgc tgctgctgtc cctggtcatc       60

aca                                                                     63


<210>  131
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  131

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  132
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding CD28 transmembrane domain

<400>  132
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210>  133
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulating domain

<400>  133

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  134
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding CD28 co-stimulating domain

<400>  134
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  135
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB co-stimulating domain

<400>  135

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  136
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding 4-1BB co-stimulating domain

<400>  136
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  137
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zlso1

<400>  137

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  138
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zIso3

<400>  138

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  139
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NA encoding CD3zIso3

<400>  139
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgctaa                             339


