                         б

<110>  ϺƼ޹˾
 
<120>  ͻ׼Ʊ;

<130>  FPCH21160291P

<160>  4     

<170>  PatentIn version 3.3

<210>  1
<211>  1248
<212>  PRT
<213>  ˹

<400>  1

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro 
            20                  25                  30          


Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val 
        35                  40                  45              


Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe 
    50                  55                  60                  


Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
65                  70                  75                  80  


Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val 
                85                  90                  95      


Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe 
            100                 105                 110         


Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn 
        115                 120                 125             


Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp 
    130                 135                 140                 


Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu 
145                 150                 155                 160 


Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr 
                165                 170                 175     


Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe 
            180                 185                 190         


Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys 
        195                 200                 205             


Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln 
    210                 215                 220                 


Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn 
225                 230                 235                 240 


Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr 
                245                 250                 255     


Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr 
            260                 265                 270         


Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn 
        275                 280                 285             


Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu 
    290                 295                 300                 


Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln 
305                 310                 315                 320 


Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro 
                325                 330                 335     


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
            340                 345                 350         


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
        355                 360                 365             


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys 
    370                 375                 380                 


Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
385                 390                 395                 400 


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
                405                 410                 415     


Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
            420                 425                 430         


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
        435                 440                 445             


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys 
    450                 455                 460                 


Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln 
465                 470                 475                 480 


Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe 
                485                 490                 495     


Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln 
            500                 505                 510         


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala 
        515                 520                 525             


Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys 
    530                 535                 540                 


Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu 
545                 550                 555                 560 


Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala 
                565                 570                 575     


Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
            580                 585                 590         


Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
        595                 600                 605             


Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
    610                 615                 620                 


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
625                 630                 635                 640 


Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu 
                645                 650                 655     


Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile 
            660                 665                 670         


Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly 
        675                 680                 685             


Gly Ser Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser 
    690                 695                 700                 


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
705                 710                 715                 720 


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
                725                 730                 735     


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
            740                 745                 750         


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
        755                 760                 765             


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
    770                 775                 780                 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
785                 790                 795                 800 


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
                805                 810                 815     


Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val 
            820                 825                 830         


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
        835                 840                 845             


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
    850                 855                 860                 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
865                 870                 875                 880 


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
                885                 890                 895     


Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe 
            900                 905                 910         


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
        915                 920                 925             


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
    930                 935                 940                 


Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
945                 950                 955                 960 


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
                965                 970                 975     


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro 
            980                 985                 990         


Pro Glu Ala Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
        995                 1000                 1005             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1010                 1015                 1020             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1025                 1030                 1035             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1040                 1045                 1050             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1055                 1060                 1065             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1070                 1075                 1080             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1085                 1090                 1095             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1100                 1105                 1110             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1115                 1120                 1125             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1130                 1135                 1140             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1145                 1150                 1155             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1160                 1165                 1170             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1175                 1180                 1185             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1190                 1195                 1200             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1205                 1210                 1215             


Pro Gly  Ser Gly Tyr Ile Pro  Glu Ala Pro Arg Asp  Gly Gln Ala 
    1220                 1225                 1230             


Tyr Val  Arg Lys Asp Gly Glu  Trp Val Leu Leu Ser  Thr Phe Leu 
    1235                 1240                 1245             


<210>  2
<211>  3750
<212>  DNA
<213>  ˹

<400>  2
atggagttcg gcctgagctg gctgttcctg gtggccatcc tgaagggcgt gcagtgtcag     60

tgcgtgaacc tgaccacaag gacccagctg ccacctgcct ataccaactc tttcacaagg    120

ggcgtgtact atcctgacaa ggtgtttcgg tccagcgtgc tgcactccac acaggatctg    180

tttctgccat tctttagcaa cgtgacctgg ttccacgcta tccacgtgtc cggcaccaat    240

ggcacaaaga gattcgacaa tcctgtgctg cccttcaacg atggcgtgta cttcgcctcc    300

accgagaaga gcaacatcat ccgcggctgg atctttggca ccacactgga ctctaagaca    360

cagtccctgc tgatcgtgaa caatgctacc aacgtggtca tcaaggtgtg cgagttccag    420

ttttgtaatg atcccttcct gggcgtgtac tatcataaga acaataagag ctggatggag    480

tctgagtttc gggtgtattc ttccgccaac aattgtacat ttgagtacgt gtctcagcct    540

ttcctgatgg acctggaggg caagcagggc aatttcaaga acctgaggga gttcgtgttt    600

aagaatatcg atggctactt caagatctac agcaagcaca cccccatcaa cctggtgcgg    660

gacctgcctc agggcttctc tgccctggag cccctggtgg atctgcctat cggcatcaac    720

atcaccaggt ttcagacact gctggccctg catcggtcct acctgacacc cggcgacagc    780

tcttccggat ggaccgctgg agctgctgcc tactatgtgg gctatctgca gcctaggacc    840

ttcctgctga agtacaacga gaatggcacc atcacagacg ctgtggattg cgccctggac    900

cctctgagcg agaccaagtg tacactgaag tcttttaccg tggagaaggg catctatcag    960

acatctaatt tcagagtgca gccaaccgag tccatcgtgc gctttcctaa tatcacaaac   1020

ctgtgcccat ttggcgaggt gttcaacgct acccggttcg ccagcgtgta cgcttggaat   1080

aggaagcgga tcagcaactg cgtggccgac tattctgtgc tgtacaactc cgcctccttc   1140

tccaccttca agtgctatgg cgtgtccccc acaaagctga atgacctgtg ctttaccaac   1200

gtgtacgctg attcgttcgt gatcaggggc gacgaggtgc ggcagatcgc tcctggacag   1260

acaggcaaga tcgctgacta caattataag ctgccagacg acttcaccgg ctgcgtgatc   1320

gcctggaaca gcaacaatct ggattctaaa gtgggcggca actacaatta tctgtacaga   1380

ctgtttcgca agagcaatct gaagcccttc gagagggaca tctccacaga gatctaccag   1440

gccggcagca ccccttgcaa tggcgtggag ggctttaact gttatttccc actgcagtct   1500

tacggcttcc agcccaccaa cggcgtgggc tatcagcctt accgggtggt ggtgctgtct   1560

tttgagctgc tgcacgctcc agctacagtg tgcggaccca agaagtccac caatctggtg   1620

aagaacaagt gcgtgaactt caacttcaac ggactgaccg gaacaggcgt gctgaccgag   1680

agcaacaaga agttcctgcc atttcagcag ttcggcagag acatcgccga taccacagac   1740

gctgtgcgcg acccacagac cctggagatc ctggatatca caccctgctc cttcggcggc   1800

gtgagcgtga tcacaccagg aaccaataca tctaaccagg tggccgtgct gtatcaggac   1860

gtgaactgta ccgaggtgcc tgtggctatc cacgccgatc agctgacccc aacatggagg   1920

gtgtactcta ccggctccaa cgtgtttcag acaagggctg gatgtctgat cggagctgag   1980

catgtgaaca atagctatga gtgcgacatc ccaatcggcg ccggcatctg tgcttcctac   2040

cagacccaga caaacagccc aggaggaagc ggatctgtgg cttcccagag catcatcgct   2100

tataccatgt ccctgggcgc cgagaatagc gtggcttaca gcaacaatag catcgctatc   2160

ccaaccaact tcacaatctc cgtgaccaca gagatcctgc ccgtgtctat gaccaagaca   2220

tccgtggact gcacaatgta tatctgtggc gattccaccg agtgcagcaa cctgctgctg   2280

cagtacggct cgttttgtac ccagctgaat agagccctga caggcatcgc tgtggagcag   2340

gataagaaca cacaggaggt gttcgcccag gtgaagcaga tctacaagac cccacccatc   2400

aaggactttg gcggcttcaa tttttctcag atcctgccag atccctccaa gcccagcaag   2460

agatctttta tcgaggacct gctgttcaac aaggtgaccc tggctgatgc cggcttcatc   2520

aagcagtatg gcgattgcct gggcgacatc gctgctaggg acctgatctg tgcccagaag   2580

tttaatggcc tgaccgtgct gcctccactg ctgacagatg agatgatcgc tcagtacaca   2640

tccgccctgc tggccggcac catcacatct ggatggacct tcggcgctgg agctgccctg   2700

cagatccctt ttgccatgca gatggcttat cgcttcaacg gcatcggcgt gacccagaat   2760

gtgctgtacg agaaccagaa gctgatcgcc aatcagttta actccgctat cggcaagatc   2820

caggactctc tgagctctac agcctccgcc ctgggcaagc tgcaggatgt ggtgaatcag   2880

aacgctcagg ccctgaatac cctggtgaag cagctgtcca gcaacttcgg cgccatctct   2940

tccgtgctga atgatatcct gagcagactg gacccccctg aggctgaggt gcagatcgac   3000

agactgatca caggccgcct gcagagcctg cagacctacg tgacacagca gctgatcagg   3060

gctgccgaga tccgggcttc tgccaacctg gctgccacca agatgtctga gtgcgtgctg   3120

ggccagtcca agcgcgtgga cttttgtggc aagggctatc acctgatgtc tttccctcag   3180

tccgccccac acggcgtggt gtttctgcat gtgacctacg tgcccgctca ggagaagaac   3240

ttcaccacag ctcctgccat ctgccacgat ggcaaggccc attttccaag agagggcgtg   3300

ttcgtgtcta acggcaccca ttggtttgtg acacagcgca atttctacga gccccagatc   3360

atcaccacag acaatacctt cgtgtccggc aactgtgacg tggtcatcgg catcgtgaac   3420

aataccgtgt atgatcccct gcagcctgag ctggactctt ttaaggagga gctggataag   3480

tacttcaaga atcatacctc ccctgacgtg gatctgggcg acatcagcgg catcaatgcc   3540

tctgtggtga acatccagaa ggagatcgac aggctgaacg aggtggctaa gaatctgaac   3600

gagtccctga tcgatctgca ggagctgggc aagtatgagc agtacatcaa gtggccaggc   3660

agcggctata tcccagaggc tccaagagac ggacaggctt acgtgcgcaa ggatggcgag   3720

tgggtgctgc tgtctacctt cctgtgatga                                    3750


<210>  3
<211>  1229
<212>  PRT
<213>  ˹

<400>  3

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Gly Ser Gly 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Gly Ser Gly 
    1190                 1195                 1200             


Tyr Ile  Pro Glu Ala Pro Arg  Asp Gly Gln Ala Tyr  Val Arg Lys 
    1205                 1210                 1215             


Asp Gly  Glu Trp Val Leu Leu  Ser Thr Phe Leu 
    1220                 1225                 


<210>  4
<211>  3693
<212>  DNA
<213>  ˹

<400>  4
cagtgcgtga acctgaccac aaggacccag ctgccacctg cctataccaa ctctttcaca     60

aggggcgtgt actatcctga caaggtgttt cggtccagcg tgctgcactc cacacaggat    120

ctgtttctgc cattctttag caacgtgacc tggttccacg ctatccacgt gtccggcacc    180

aatggcacaa agagattcga caatcctgtg ctgcccttca acgatggcgt gtacttcgcc    240

tccaccgaga agagcaacat catccgcggc tggatctttg gcaccacact ggactctaag    300

acacagtccc tgctgatcgt gaacaatgct accaacgtgg tcatcaaggt gtgcgagttc    360

cagttttgta atgatccctt cctgggcgtg tactatcata agaacaataa gagctggatg    420

gagtctgagt ttcgggtgta ttcttccgcc aacaattgta catttgagta cgtgtctcag    480

cctttcctga tggacctgga gggcaagcag ggcaatttca agaacctgag ggagttcgtg    540

tttaagaata tcgatggcta cttcaagatc tacagcaagc acacccccat caacctggtg    600

cgggacctgc ctcagggctt ctctgccctg gagcccctgg tggatctgcc tatcggcatc    660

aacatcacca ggtttcagac actgctggcc ctgcatcggt cctacctgac acccggcgac    720

agctcttccg gatggaccgc tggagctgct gcctactatg tgggctatct gcagcctagg    780

accttcctgc tgaagtacaa cgagaatggc accatcacag acgctgtgga ttgcgccctg    840

gaccctctga gcgagaccaa gtgtacactg aagtctttta ccgtggagaa gggcatctat    900

cagacatcta atttcagagt gcagccaacc gagtccatcg tgcgctttcc taatatcaca    960

aacctgtgcc catttggcga ggtgttcaac gctacccggt tcgccagcgt gtacgcttgg   1020

aataggaagc ggatcagcaa ctgcgtggcc gactattctg tgctgtacaa ctccgcctcc   1080

ttctccacct tcaagtgcta tggcgtgtcc cccacaaagc tgaatgacct gtgctttacc   1140

aacgtgtacg ctgattcgtt cgtgatcagg ggcgacgagg tgcggcagat cgctcctgga   1200

cagacaggca agatcgctga ctacaattat aagctgccag acgacttcac cggctgcgtg   1260

atcgcctgga acagcaacaa tctggattct aaagtgggcg gcaactacaa ttatctgtac   1320

agactgtttc gcaagagcaa tctgaagccc ttcgagaggg acatctccac agagatctac   1380

caggccggca gcaccccttg caatggcgtg gagggcttta actgttattt cccactgcag   1440

tcttacggct tccagcccac caacggcgtg ggctatcagc cttaccgggt ggtggtgctg   1500

tcttttgagc tgctgcacgc tccagctaca gtgtgcggac ccaagaagtc caccaatctg   1560

gtgaagaaca agtgcgtgaa cttcaacttc aacggactga ccggaacagg cgtgctgacc   1620

gagagcaaca agaagttcct gccatttcag cagttcggca gagacatcgc cgataccaca   1680

gacgctgtgc gcgacccaca gaccctggag atcctggata tcacaccctg ctccttcggc   1740

ggcgtgagcg tgatcacacc aggaaccaat acatctaacc aggtggccgt gctgtatcag   1800

gacgtgaact gtaccgaggt gcctgtggct atccacgccg atcagctgac cccaacatgg   1860

agggtgtact ctaccggctc caacgtgttt cagacaaggg ctggatgtct gatcggagct   1920

gagcatgtga acaatagcta tgagtgcgac atcccaatcg gcgccggcat ctgtgcttcc   1980

taccagaccc agacaaacag cccaggagga agcggatctg tggcttccca gagcatcatc   2040

gcttatacca tgtccctggg cgccgagaat agcgtggctt acagcaacaa tagcatcgct   2100

atcccaacca acttcacaat ctccgtgacc acagagatcc tgcccgtgtc tatgaccaag   2160

acatccgtgg actgcacaat gtatatctgt ggcgattcca ccgagtgcag caacctgctg   2220

ctgcagtacg gctcgttttg tacccagctg aatagagccc tgacaggcat cgctgtggag   2280

caggataaga acacacagga ggtgttcgcc caggtgaagc agatctacaa gaccccaccc   2340

atcaaggact ttggcggctt caatttttct cagatcctgc cagatccctc caagcccagc   2400

aagagatctt ttatcgagga cctgctgttc aacaaggtga ccctggctga tgccggcttc   2460

atcaagcagt atggcgattg cctgggcgac atcgctgcta gggacctgat ctgtgcccag   2520

aagtttaatg gcctgaccgt gctgcctcca ctgctgacag atgagatgat cgctcagtac   2580

acatccgccc tgctggccgg caccatcaca tctggatgga ccttcggcgc tggagctgcc   2640

ctgcagatcc cttttgccat gcagatggct tatcgcttca acggcatcgg cgtgacccag   2700

aatgtgctgt acgagaacca gaagctgatc gccaatcagt ttaactccgc tatcggcaag   2760

atccaggact ctctgagctc tacagcctcc gccctgggca agctgcagga tgtggtgaat   2820

cagaacgctc aggccctgaa taccctggtg aagcagctgt ccagcaactt cggcgccatc   2880

tcttccgtgc tgaatgatat cctgagcaga ctggaccccc ctgaggctga ggtgcagatc   2940

gacagactga tcacaggccg cctgcagagc ctgcagacct acgtgacaca gcagctgatc   3000

agggctgccg agatccgggc ttctgccaac ctggctgcca ccaagatgtc tgagtgcgtg   3060

ctgggccagt ccaagcgcgt ggacttttgt ggcaagggct atcacctgat gtctttccct   3120

cagtccgccc cacacggcgt ggtgtttctg catgtgacct acgtgcccgc tcaggagaag   3180

aacttcacca cagctcctgc catctgccac gatggcaagg cccattttcc aagagagggc   3240

gtgttcgtgt ctaacggcac ccattggttt gtgacacagc gcaatttcta cgagccccag   3300

atcatcacca cagacaatac cttcgtgtcc ggcaactgtg acgtggtcat cggcatcgtg   3360

aacaataccg tgtatgatcc cctgcagcct gagctggact cttttaagga ggagctggat   3420

aagtacttca agaatcatac ctcccctgac gtggatctgg gcgacatcag cggcatcaat   3480

gcctctgtgg tgaacatcca gaaggagatc gacaggctga acgaggtggc taagaatctg   3540

aacgagtccc tgatcgatct gcaggagctg ggcaagtatg agcagtacat caagtggcca   3600

ggcagcggct atatcccaga ggctccaaga gacggacagg cttacgtgcg caaggatggc   3660

gagtgggtgc tgctgtctac cttcctgtga tga                                3693


