                         SEQUENCE LISTING

<110>  Eluminex Biosciences (Suzhou) Limited
 
<120>  Inhibitors of Angiogenic Factors

<130>  076908-8001WO01

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  306
<212>  DNA
<213>  Homo sapiens

<400>  1
agtgataccg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg       60

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      120

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      180

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      240

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccaataca      300

atcata                                                                 306


<210>  2
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile 
            100         


<210>  3
<211>  309
<212>  DNA
<213>  Homo sapiens

<400>  3
gatgtggttc tgagtccgtc tcatggaatt gaactatctg ttggagaaaa gcttgtctta       60

aattgtacag caagaactga actaaatgtg gggattgact tcaactggga atacccttct      120

tcgaagcatc agcataagaa acttgtaaac cgagacctaa aaacccagtc tgggagtgag      180

atgaagaaat ttttgagcac cttaactata gatggtgtaa cccggagtga ccaaggattg      240

tacacctgtg cagcatccag tgggctgatg accaagaaga acagcacatt tgtcagggtc      300

catgaaaag                                                              309


<210>  4
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
1               5                   10                  15      


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
            20                  25                  30          


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
        35                  40                  45              


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
    50                  55                  60                  


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
65                  70                  75                  80  


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
                85                  90                  95      


Phe Val Arg Val His Glu Lys 
            100             


<210>  5
<211>  614
<212>  DNA
<213>  Homo sapiens

<400>  5
tactccatga cccccccgac cttgaacatc acggaggagt cacacgtcat cgacaccggt       60

gacagcctgt ccatctcctg caggggacag caccccctcg agtgggcttg gccaggagct      120

caggaggcgc cagccaccgg agacaaggac agcgaggaca cgggggtggt gcgagactgc      180

gagggcacag acgccaggcc ctactgcaag gtgttgctgc tgcacgaggt acatgccaac      240

gacacaggca gctacgtctg ctactacaag tacatcaagg cacgcatcga gggcaccacg      300

gccgccagct cctacgtgtt cgtgagagac tttgagcagc cattcatcaa caagcctgac      360

acgctcttgg tcaacaggaa ggacgccatg tgggtgccct gtctggtgtc catccccggc      420

ctcaatgtca cgctgcgctc gcaaagctcg gtgctgtggc cagacgggca ggaggtggtg      480

tgggatgacc ggcggggcat gctcgtgtcc acgccactgc tgcacgatgc cctgtacctg      540

cagtgcgaga ccacctgggg agaccaggac ttcctttcca accccttcct ggtgcacatc      600

acaggcaacg agct                                                        614


<210>  6
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  6

Tyr Ser Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val 
1               5                   10                  15      


Ile Asp Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro 
            20                  25                  30          


Leu Glu Trp Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp 
        35                  40                  45              


Lys Asp Ser Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp 
    50                  55                  60                  


Ala Arg Pro Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn 
65                  70                  75                  80  


Asp Thr Gly Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile 
                85                  90                  95      


Glu Gly Thr Thr Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu 
            100                 105                 110         


Gln Pro Phe Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp 
        115                 120                 125             


Ala Met Trp Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr 
    130                 135                 140                 


Leu Arg Ser Gln Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val 
145                 150                 155                 160 


Trp Asp Asp Arg Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp 
                165                 170                 175     


Ala Leu Tyr Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu 
            180                 185                 190         


Ser Asn Pro Phe Leu Val His Ile Thr Gly Asn Glu Leu 
        195                 200                 205 


<210>  7
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  7
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggt                                                    678


<210>  8
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  9
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  9
ggtggctctg gagggggttc cggtggcgga ggttcaggtg gcggaggggg ttcgggtggc       60

ggaggg                                                                  66


<210>  10
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly 
            20          


<210>  11
<211>  1974
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  11
agtgataccg gtagaccttt cgtagagatg tacagtgaaa tccccgaaat tatacacatg       60

actgaaggaa gggagctcgt cattccctgc cgggttacgt cacctaacat cactgttact      120

ttaaaaaagt ttccacttga cactttgatc cctgatggaa aacgcataat ctgggacagt      180

agaaagggct tcatcatatc aaatgcaacg tacaaagaaa tagggcttct gacctgtgaa      240

gcaacagtca atgggcattt gtataagaca aactatctca cacatcgaca aaccaataca      300

atcatagatg tggttctgag tccgtctcat ggaattgaac tatctgttgg agaaaagctt      360

gtcttaaatt gtacagcaag aactgaacta aatgtgggga ttgacttcaa ctgggaatac      420

ccttcttcga agcatcagca taagaaactt gtaaaccgag acctaaaaac ccagtctggg      480

agtgagatga agaaattttt gagcacctta actatagatg gtgtaacccg gagtgaccaa      540

ggattgtaca cctgtgcagc atccagtggg ctgatgacca agaagaacag cacatttgtc      600

agggtccatg aaaagtactc catgaccccc ccgaccttga acatcacgga ggagtcacac      660

gtcatcgaca ccggtgacag cctgtccatc tcctgcaggg gacagcaccc cctcgagtgg      720

gcttggccag gagctcagga ggcgccagcc accggagaca aggacagcga ggacacgggg      780

gtggtgcgag actgcgaggg cacagacgcc aggccctact gcaaggtgtt gctgctgcac      840

gaggtacatg ccaacgacac aggcagctac gtctgctact acaagtacat caaggcacgc      900

atcgagggca ccacggccgc cagctcctac gtgttcgtga gagactttga gcagccattc      960

atcaacaagc ctgacacgct cttggtcaac aggaaggacg ccatgtgggt gccctgtctg     1020

gtgtccatcc ccggcctcaa tgtcacgctg cgctcgcaaa gctcggtgct gtggccagac     1080

gggcaggagg tggtgtggga tgaccggcgg ggcatgctcg tgtccacgcc actgctgcac     1140

gatgccctgt acctgcagtg cgagaccacc tggggagacc aggacttcct ttccaacccc     1200

ttcctggtgc acatcacagg caacgagctc ggtggctctg gagggggttc cggtggcgga     1260

ggttcaggtg gcggaggggg ttcgggtggc ggaggggaca aaactcacac atgcccaccg     1320

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     1380

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     1440

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1500

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1560

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1620

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1680

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1740

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1800

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1860

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1920

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggt           1974


<210>  12
<211>  658
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Tyr Ser Met 
        195                 200                 205             


Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr 
    210                 215                 220                 


Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp 
225                 230                 235                 240 


Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser 
                245                 250                 255     


Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro 
            260                 265                 270         


Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn Asp Thr Gly 
        275                 280                 285             


Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr 
    290                 295                 300                 


Thr Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe 
305                 310                 315                 320 


Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp 
                325                 330                 335     


Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser 
            340                 345                 350         


Gln Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp 
        355                 360                 365             


Arg Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr 
    370                 375                 380                 


Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro 
385                 390                 395                 400 


Phe Leu Val His Ile Thr Gly Asn Glu Leu Gly Gly Ser Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            420                 425                 430         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        435                 440                 445             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    450                 455                 460                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
465                 470                 475                 480 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                485                 490                 495     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            500                 505                 510         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        515                 520                 525             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    530                 535                 540                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
545                 550                 555                 560 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                565                 570                 575     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            580                 585                 590         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        595                 600                 605             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    610                 615                 620                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
625                 630                 635                 640 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                645                 650                 655     


Pro Gly 
        


<210>  13
<211>  1363
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gln Arg Gly Ala Ala Leu Cys Leu Arg Leu Trp Leu Cys Leu Gly 
1               5                   10                  15      


Leu Leu Asp Gly Leu Val Ser Gly Tyr Ser Met Thr Pro Pro Thr Leu 
            20                  25                  30          


Asn Ile Thr Glu Glu Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser 
        35                  40                  45              


Ile Ser Cys Arg Gly Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala 
    50                  55                  60                  


Gln Glu Ala Pro Ala Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val 
65                  70                  75                  80  


Val Arg Asp Cys Glu Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu 
                85                  90                  95      


Leu Leu His Glu Val His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr 
            100                 105                 110         


Tyr Lys Tyr Ile Lys Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser 
        115                 120                 125             


Tyr Val Phe Val Arg Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp 
    130                 135                 140                 


Thr Leu Leu Val Asn Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val 
145                 150                 155                 160 


Ser Ile Pro Gly Leu Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu 
                165                 170                 175     


Trp Pro Asp Gly Gln Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu 
            180                 185                 190         


Val Ser Thr Pro Leu Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr 
        195                 200                 205             


Thr Trp Gly Asp Gln Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile 
    210                 215                 220                 


Thr Gly Asn Glu Leu Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu 
225                 230                 235                 240 


Glu Leu Leu Val Gly Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala 
                245                 250                 255     


Glu Phe Asn Ser Gly Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln 
            260                 265                 270         


Ala Glu Arg Gly Lys Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His 
        275                 280                 285             


Thr Glu Leu Ser Ser Ile Leu Thr Ile His Asn Val Ser Gln His Asp 
    290                 295                 300                 


Leu Gly Ser Tyr Val Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg 
305                 310                 315                 320 


Glu Ser Thr Glu Val Ile Val His Glu Asn Pro Phe Ile Ser Val Glu 
                325                 330                 335     


Trp Leu Lys Gly Pro Ile Leu Glu Ala Thr Ala Gly Asp Glu Leu Val 
            340                 345                 350         


Lys Leu Pro Val Lys Leu Ala Ala Tyr Pro Pro Pro Glu Phe Gln Trp 
        355                 360                 365             


Tyr Lys Asp Gly Lys Ala Leu Ser Gly Arg His Ser Pro His Ala Leu 
    370                 375                 380                 


Val Leu Lys Glu Val Thr Glu Ala Ser Thr Gly Thr Tyr Thr Leu Ala 
385                 390                 395                 400 


Leu Trp Asn Ser Ala Ala Gly Leu Arg Arg Asn Ile Ser Leu Glu Leu 
                405                 410                 415     


Val Val Asn Val Pro Pro Gln Ile His Glu Lys Glu Ala Ser Ser Pro 
            420                 425                 430         


Ser Ile Tyr Ser Arg His Ser Arg Gln Ala Leu Thr Cys Thr Ala Tyr 
        435                 440                 445             


Gly Val Pro Leu Pro Leu Ser Ile Gln Trp His Trp Arg Pro Trp Thr 
    450                 455                 460                 


Pro Cys Lys Met Phe Ala Gln Arg Ser Leu Arg Arg Arg Gln Gln Gln 
465                 470                 475                 480 


Asp Leu Met Pro Gln Cys Arg Asp Trp Arg Ala Val Thr Thr Gln Asp 
                485                 490                 495     


Ala Val Asn Pro Ile Glu Ser Leu Asp Thr Trp Thr Glu Phe Val Glu 
            500                 505                 510         


Gly Lys Asn Lys Thr Val Ser Lys Leu Val Ile Gln Asn Ala Asn Val 
        515                 520                 525             


Ser Ala Met Tyr Lys Cys Val Val Ser Asn Lys Val Gly Gln Asp Glu 
    530                 535                 540                 


Arg Leu Ile Tyr Phe Tyr Val Thr Thr Ile Pro Asp Gly Phe Thr Ile 
545                 550                 555                 560 


Glu Ser Lys Pro Ser Glu Glu Leu Leu Glu Gly Gln Pro Val Leu Leu 
                565                 570                 575     


Ser Cys Gln Ala Asp Ser Tyr Lys Tyr Glu His Leu Arg Trp Tyr Arg 
            580                 585                 590         


Leu Asn Leu Ser Thr Leu His Asp Ala His Gly Asn Pro Leu Leu Leu 
        595                 600                 605             


Asp Cys Lys Asn Val His Leu Phe Ala Thr Pro Leu Ala Ala Ser Leu 
    610                 615                 620                 


Glu Glu Val Ala Pro Gly Ala Arg His Ala Thr Leu Ser Leu Ser Ile 
625                 630                 635                 640 


Pro Arg Val Ala Pro Glu His Glu Gly His Tyr Val Cys Glu Val Gln 
                645                 650                 655     


Asp Arg Arg Ser His Asp Lys His Cys His Lys Lys Tyr Leu Ser Val 
            660                 665                 670         


Gln Ala Leu Glu Ala Pro Arg Leu Thr Gln Asn Leu Thr Asp Leu Leu 
        675                 680                 685             


Val Asn Val Ser Asp Ser Leu Glu Met Gln Cys Leu Val Ala Gly Ala 
    690                 695                 700                 


His Ala Pro Ser Ile Val Trp Tyr Lys Asp Glu Arg Leu Leu Glu Glu 
705                 710                 715                 720 


Lys Ser Gly Val Asp Leu Ala Asp Ser Asn Gln Lys Leu Ser Ile Gln 
                725                 730                 735     


Arg Val Arg Glu Glu Asp Ala Gly Arg Tyr Leu Cys Ser Val Cys Asn 
            740                 745                 750         


Ala Lys Gly Cys Val Asn Ser Ser Ala Ser Val Ala Val Glu Gly Ser 
        755                 760                 765             


Glu Asp Lys Gly Ser Met Glu Ile Val Ile Leu Val Gly Thr Gly Val 
    770                 775                 780                 


Ile Ala Val Phe Phe Trp Val Leu Leu Leu Leu Ile Phe Cys Asn Met 
785                 790                 795                 800 


Arg Arg Pro Ala His Ala Asp Ile Lys Thr Gly Tyr Leu Ser Ile Ile 
                805                 810                 815     


Met Asp Pro Gly Glu Val Pro Leu Glu Glu Gln Cys Glu Tyr Leu Ser 
            820                 825                 830         


Tyr Asp Ala Ser Gln Trp Glu Phe Pro Arg Glu Arg Leu His Leu Gly 
        835                 840                 845             


Arg Val Leu Gly Tyr Gly Ala Phe Gly Lys Val Val Glu Ala Ser Ala 
    850                 855                 860                 


Phe Gly Ile His Lys Gly Ser Ser Cys Asp Thr Val Ala Val Lys Met 
865                 870                 875                 880 


Leu Lys Glu Gly Ala Thr Ala Ser Glu His Arg Ala Leu Met Ser Glu 
                885                 890                 895     


Leu Lys Ile Leu Ile His Ile Gly Asn His Leu Asn Val Val Asn Leu 
            900                 905                 910         


Leu Gly Ala Cys Thr Lys Pro Gln Gly Pro Leu Met Val Ile Val Glu 
        915                 920                 925             


Phe Cys Lys Tyr Gly Asn Leu Ser Asn Phe Leu Arg Ala Lys Arg Asp 
    930                 935                 940                 


Ala Phe Ser Pro Cys Ala Glu Lys Ser Pro Glu Gln Arg Gly Arg Phe 
945                 950                 955                 960 


Arg Ala Met Val Glu Leu Ala Arg Leu Asp Arg Arg Arg Pro Gly Ser 
                965                 970                 975     


Ser Asp Arg Val Leu Phe Ala Arg Phe Ser Lys Thr Glu Gly Gly Ala 
            980                 985                 990         


Arg Arg Ala Ser Pro Asp Gln Glu  Ala Glu Asp Leu Trp  Leu Ser Pro 
        995                 1000                 1005             


Leu Thr  Met Glu Asp Leu Val  Cys Tyr Ser Phe Gln  Val Ala Arg 
    1010                 1015                 1020             


Gly Met  Glu Phe Leu Ala Ser  Arg Lys Cys Ile His  Arg Asp Leu 
    1025                 1030                 1035             


Ala Ala  Arg Asn Ile Leu Leu  Ser Glu Ser Asp Val  Val Lys Ile 
    1040                 1045                 1050             


Cys Asp  Phe Gly Leu Ala Arg  Asp Ile Tyr Lys Asp  Pro Asp Tyr 
    1055                 1060                 1065             


Val Arg  Lys Gly Ser Ala Arg  Leu Pro Leu Lys Trp  Met Ala Pro 
    1070                 1075                 1080             


Glu Ser  Ile Phe Asp Lys Val  Tyr Thr Thr Gln Ser  Asp Val Trp 
    1085                 1090                 1095             


Ser Phe  Gly Val Leu Leu Trp  Glu Ile Phe Ser Leu  Gly Ala Ser 
    1100                 1105                 1110             


Pro Tyr  Pro Gly Val Gln Ile  Asn Glu Glu Phe Cys  Gln Arg Leu 
    1115                 1120                 1125             


Arg Asp  Gly Thr Arg Met Arg  Ala Pro Glu Leu Ala  Thr Pro Ala 
    1130                 1135                 1140             


Ile Arg  Arg Ile Met Leu Asn  Cys Trp Ser Gly Asp  Pro Lys Ala 
    1145                 1150                 1155             


Arg Pro  Ala Phe Ser Glu Leu  Val Glu Ile Leu Gly  Asp Leu Leu 
    1160                 1165                 1170             


Gln Gly  Arg Gly Leu Gln Glu  Glu Glu Glu Val Cys  Met Ala Pro 
    1175                 1180                 1185             


Arg Ser  Ser Gln Ser Ser Glu  Glu Gly Ser Phe Ser  Gln Val Ser 
    1190                 1195                 1200             


Thr Met  Ala Leu His Ile Ala  Gln Ala Asp Ala Glu  Asp Ser Pro 
    1205                 1210                 1215             


Pro Ser  Leu Gln Arg His Ser  Leu Ala Ala Arg Tyr  Tyr Asn Trp 
    1220                 1225                 1230             


Val Ser  Phe Pro Gly Cys Leu  Ala Arg Gly Ala Glu  Thr Arg Gly 
    1235                 1240                 1245             


Ser Ser  Arg Met Lys Thr Phe  Glu Glu Phe Pro Met  Thr Pro Thr 
    1250                 1255                 1260             


Thr Tyr  Lys Gly Ser Val Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1265                 1270                 1275             


Leu Ala  Ser Glu Glu Phe Glu  Gln Ile Glu Ser Arg  His Arg Gln 
    1280                 1285                 1290             


Glu Ser  Gly Phe Ser Cys Lys  Gly Pro Gly Gln Asn  Val Ala Val 
    1295                 1300                 1305             


Thr Arg  Ala His Pro Asp Ser  Gln Gly Arg Arg Arg  Arg Pro Glu 
    1310                 1315                 1320             


Arg Gly  Ala Arg Gly Gly Gln  Val Phe Tyr Asn Ser  Glu Tyr Gly 
    1325                 1330                 1335             


Glu Leu  Ser Glu Pro Ser Glu  Glu Asp His Cys Ser  Pro Ser Ala 
    1340                 1345                 1350             


Arg Val  Thr Phe Phe Thr Asp  Asn Ser Tyr 
    1355                 1360             


<210>  14
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  14

Tyr Ser Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val 
1               5                   10                  15      


Ile Asp Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro 
            20                  25                  30          


Leu Glu Trp Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp 
        35                  40                  45              


Lys Asp Ser Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp 
    50                  55                  60                  


Ala Arg Pro Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn 
65                  70                  75                  80  


Asp Thr Gly Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile 
                85                  90                  95      


Glu Gly Thr Thr Ala Ala Ser 
            100             


<210>  15
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  15

Tyr Ser Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu Ser His Val 
1               5                   10                  15      


Ile Asp Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly Gln His Pro 
            20                  25                  30          


Leu Glu Trp Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala Thr Gly Asp 
        35                  40                  45              


Lys Asp Ser Glu Asp Thr Gly Val Val Arg Asp Cys Glu Gly Thr Asp 
    50                  55                  60                  


Ala Arg Pro Tyr Cys Lys Val Leu Leu Leu His Glu Val His Ala Asn 
65                  70                  75                  80  


Asp Thr Gly Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys Ala Arg Ile 
                85                  90                  95      


Glu Gly Thr Thr Ala Ala Ser Ser Tyr Val Phe Val Arg Asp Phe Glu 
            100                 105                 110         


Gln Pro Phe Ile Asn Lys Pro Asp Thr Leu Leu Val Asn Arg Lys Asp 
        115                 120                 125             


Ala Met Trp Val Pro Cys Leu Val Ser Ile Pro Gly Leu Asn Val Thr 
    130                 135                 140                 


Leu Arg Ser Gln Ser Ser Val Leu Trp Pro Asp Gly Gln Glu Val Val 
145                 150                 155                 160 


Trp Asp Asp Arg Arg Gly Met Leu Val Ser Thr Pro Leu Leu His Asp 
                165                 170                 175     


Ala Leu Tyr Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln Asp Phe Leu 
            180                 185                 190         


Ser Asn Pro Phe Leu Val His Ile Thr Gly Asn Glu Leu Tyr Asp Ile 
        195                 200                 205             


Gln Leu Leu Pro Arg Lys Ser Leu Glu Leu Leu Val Gly Glu Lys Leu 
    210                 215                 220                 


Val Leu Asn Cys Thr Val Trp Ala Glu Phe Asn Ser Gly Val Thr Phe 
225                 230                 235                 240 


Asp Trp Asp Tyr Pro Gly Lys Gln Ala Glu Arg Gly Lys Trp Val Pro 
                245                 250                 255     


Glu Arg Arg Ser Gln Gln Thr His Thr Glu Leu Ser Ser Ile Leu Thr 
            260                 265                 270         


Ile His Asn Val Ser Gln His Asp Leu Gly Ser Tyr Val Cys Lys Ala 
        275                 280                 285             


Asn Asn Gly Ile Gln Arg Phe Arg Glu Ser Thr Glu Val Ile Val His 
    290                 295                 300                 


Glu Asn 
305     


<210>  16
<211>  759
<212>  PRT
<213>  Artificial

<220>
<223>  Fusion protein constructed from extracellular domains of VEGFR-1,
       VEGFR-2, and VEGFR-3.

<400>  16

Ser Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu 
1               5                   10                  15      


Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val 
            20                  25                  30          


Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr 
        35                  40                  45              


Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe 
    50                  55                  60                  


Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu 
65                  70                  75                  80  


Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg 
                85                  90                  95      


Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile 
            100                 105                 110         


Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr 
        115                 120                 125             


Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys 
    130                 135                 140                 


His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly 
145                 150                 155                 160 


Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr 
                165                 170                 175     


Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met 
            180                 185                 190         


Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Gly Tyr Ser Met Thr Pro Pro Thr Leu Asn Ile Thr Glu Glu 
225                 230                 235                 240 


Ser His Val Ile Asp Thr Gly Asp Ser Leu Ser Ile Ser Cys Arg Gly 
                245                 250                 255     


Gln His Pro Leu Glu Trp Ala Trp Pro Gly Ala Gln Glu Ala Pro Ala 
            260                 265                 270         


Thr Gly Asp Lys Asp Ser Glu Asp Thr Gly Val Val Arg Asp Cys Glu 
        275                 280                 285             


Gly Thr Asp Ala Arg Pro Tyr Cys Lys Val Leu Leu Leu His Glu Val 
    290                 295                 300                 


His Ala Asn Asp Thr Gly Ser Tyr Val Cys Tyr Tyr Lys Tyr Ile Lys 
305                 310                 315                 320 


Ala Arg Ile Glu Gly Thr Thr Ala Ala Ser Ser Tyr Val Phe Val Arg 
                325                 330                 335     


Asp Phe Glu Gln Pro Phe Ile Asn Lys Pro Asp Thr Leu Leu Val Asn 
            340                 345                 350         


Arg Lys Asp Ala Met Trp Val Pro Cys Leu Val Ser Ile Pro Gly Leu 
        355                 360                 365             


Asn Val Thr Leu Arg Ser Gln Ser Ser Val Leu Trp Pro Asp Gly Gln 
    370                 375                 380                 


Glu Val Val Trp Asp Asp Arg Arg Gly Met Leu Val Ser Thr Pro Leu 
385                 390                 395                 400 


Leu His Asp Ala Leu Tyr Leu Gln Cys Glu Thr Thr Trp Gly Asp Gln 
                405                 410                 415     


Asp Phe Leu Ser Asn Pro Phe Leu Val His Ile Thr Gly Asn Glu Leu 
            420                 425                 430         


Tyr Asp Ile Gln Leu Leu Pro Arg Lys Ser Leu Glu Leu Leu Val Gly 
        435                 440                 445             


Glu Lys Leu Val Leu Asn Cys Thr Val Trp Ala Glu Phe Asn Ser Gly 
    450                 455                 460                 


Val Thr Phe Asp Trp Asp Tyr Pro Gly Lys Gln Ala Glu Arg Gly Lys 
465                 470                 475                 480 


Trp Val Pro Glu Arg Arg Ser Gln Gln Thr His Thr Glu Leu Ser Ser 
                485                 490                 495     


Ile Leu Thr Ile His Asn Val Ser Gln His Asp Leu Gly Ser Tyr Val 
            500                 505                 510         


Cys Lys Ala Asn Asn Gly Ile Gln Arg Phe Arg Glu Ser Thr Glu Val 
        515                 520                 525             


Ile Val His Glu Asn Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    530                 535                 540                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
545                 550                 555                 560 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                565                 570                 575     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            580                 585                 590         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        595                 600                 605             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    610                 615                 620                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
625                 630                 635                 640 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                645                 650                 655     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            660                 665                 670         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        675                 680                 685             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    690                 695                 700                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
705                 710                 715                 720 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                725                 730                 735     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            740                 745                 750         


Ser Leu Ser Leu Ser Pro Gly 
        755                 


