﻿               SEQUENCE LISTING

<110> Klinikum rechts der Isar der Technischen Universität München

<120> An immune checkpoint-modulating VSV-NDV hybrid virus for oncolytic virus immunotherapy of cancer

<130> K31866WO

<150> EP20205209.8
<151> 2020-11-02

<160> 26

<170> BiSSAP 1.3.6

<210> 1
<211> 288
<212> PRT
<213> Homo sapiens


<220> 
<223> Human PD1

<400> 1
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     
Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         
Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             
Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 
Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 
Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     
Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         
Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             



<210> 2
<211> 170
<212> PRT
<213> Homo sapiens


<220> 
<223> Human PD1 (soluble)

<400> 2
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val 
                165                 170 

<210> 3
<211> 170
<212> PRT
<213> Artificial Sequence


<220> 
<223> High Affinity PD1 (soluble)

<400> 3
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val 
                165                 170 

<210> 4
<211> 553
<212> PRT
<213> Artificial Sequence


<220> 
<223> NDV F3aa-modified fusion protein with L289A (amino acid sequence)

<400> 4
Met Gly Ser Arg Pro Phe Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      
Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          
Asp Gly Arg Pro Phe Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              
Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  
Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  
Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      
Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Arg 
            100                 105                 110         
Arg Gln Arg Arg Phe Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             
Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 
Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 
Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     
Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         
Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             
Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 
Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 
Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     
Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         
Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             
Ala Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 
Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 
Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     
Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         
Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             
Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 
Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 
Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     
Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         
Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             
Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 
Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 
Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     
Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         
Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             
Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 
Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             

<210> 5
<211> 577
<212> PRT
<213> Newcastle disease virus


<220> 
<223> NDV HN protein (amino acid sequence)

<400> 5
Met Asp Arg Ala Val Ser Gln Val Ala Leu Glu Asn Asp Glu Arg Glu 
1               5                   10                  15      
Ala Lys Asn Thr Trp Arg Leu Ile Phe Arg Ile Ala Ile Leu Phe Leu 
            20                  25                  30          
Thr Val Val Thr Leu Ala Ile Ser Val Ala Ser Leu Leu Tyr Ser Met 
        35                  40                  45              
Gly Ala Ser Thr Pro Ser Asp Leu Val Gly Ile Pro Thr Arg Ile Ser 
    50                  55                  60                  
Arg Ala Glu Glu Lys Ile Thr Ser Thr Leu Gly Ser Asn Gln Asp Val 
65                  70                  75                  80  
Val Asp Arg Ile Tyr Lys Gln Val Ala Leu Glu Ser Pro Leu Ala Leu 
                85                  90                  95      
Leu Asn Thr Glu Thr Thr Ile Met Asn Ala Ile Thr Ser Leu Ser Tyr 
            100                 105                 110         
Gln Ile Asn Gly Ala Ala Asn Asn Ser Gly Trp Gly Ala Pro Ile His 
        115                 120                 125             
Asp Pro Asp Tyr Ile Gly Gly Ile Gly Lys Glu Leu Ile Val Asp Asp 
    130                 135                 140                 
Ala Ser Asp Val Thr Ser Phe Tyr Pro Ser Ala Phe Gln Glu His Leu 
145                 150                 155                 160 
Asn Phe Ile Pro Ala Pro Thr Thr Gly Ser Gly Cys Thr Arg Ile Pro 
                165                 170                 175     
Ser Phe Asp Met Ser Ala Thr His Tyr Cys Tyr Thr His Asn Val Ile 
            180                 185                 190         
Leu Ser Gly Cys Arg Asp His Ser His Ser His Gln Tyr Leu Ala Leu 
        195                 200                 205             
Gly Val Leu Arg Thr Ser Ala Thr Gly Arg Val Phe Phe Ser Thr Leu 
    210                 215                 220                 
Arg Ser Ile Asn Leu Asp Asp Thr Gln Asn Arg Lys Ser Cys Ser Val 
225                 230                 235                 240 
Ser Ala Thr Pro Leu Gly Cys Asp Met Leu Cys Ser Lys Ala Thr Glu 
                245                 250                 255     
Thr Glu Glu Glu Asp Tyr Asn Ser Ala Val Pro Thr Arg Met Val His 
            260                 265                 270         
Gly Arg Leu Gly Phe Asp Gly Gln Tyr His Glu Lys Asp Leu Asp Val 
        275                 280                 285             
Thr Thr Leu Phe Gly Asp Trp Val Ala Asn Tyr Pro Gly Val Gly Gly 
    290                 295                 300                 
Gly Ser Phe Ile Asp Ser Arg Val Trp Phe Ser Val Tyr Gly Gly Leu 
305                 310                 315                 320 
Lys Pro Asn Thr Pro Ser Asp Thr Val Gln Glu Gly Lys Tyr Val Ile 
                325                 330                 335     
Tyr Lys Arg Tyr Asn Asp Thr Cys Pro Asp Glu Gln Asp Tyr Gln Ile 
            340                 345                 350         
Arg Met Ala Lys Ser Ser Tyr Lys Pro Gly Arg Phe Gly Gly Lys Arg 
        355                 360                 365             
Ile Gln Gln Ala Ile Leu Ser Ile Lys Val Ser Thr Ser Leu Gly Glu 
    370                 375                 380                 
Asp Pro Val Leu Thr Val Pro Pro Asn Thr Val Thr Leu Met Gly Ala 
385                 390                 395                 400 
Glu Gly Arg Ile Leu Thr Val Gly Thr Ser His Phe Leu Tyr Gln Arg 
                405                 410                 415     
Gly Ser Ser Tyr Phe Ser Pro Ala Leu Leu Tyr Pro Met Thr Val Ser 
            420                 425                 430         
Asp Lys Thr Ala Thr Leu His Ser Pro Tyr Thr Phe Asn Ala Phe Thr 
        435                 440                 445             
Arg Pro Gly Ser Ile Pro Cys Gln Ala Ser Ala Arg Cys Pro Asn Ser 
    450                 455                 460                 
Cys Val Thr Gly Val Tyr Thr Asp Pro Tyr Pro Leu Ile Phe Tyr Arg 
465                 470                 475                 480 
Asn His Thr Leu Arg Gly Val Phe Gly Thr Met Leu Asp Gly Glu Gln 
                485                 490                 495     
Ala Arg Leu Asn Pro Ala Ser Ala Val Phe Asp Ser Thr Ser Arg Ser 
            500                 505                 510         
Arg Ile Thr Arg Val Ser Ser Ser Ser Ile Lys Ala Ala Tyr Thr Thr 
        515                 520                 525             
Ser Thr Cys Phe Lys Val Val Lys Thr Asn Lys Thr Tyr Cys Leu Ser 
    530                 535                 540                 
Ile Ala Glu Ile Ser Asn Thr Leu Phe Gly Glu Phe Arg Ile Val Pro 
545                 550                 555                 560 
Leu Leu Val Glu Ile Leu Lys Asp Asp Gly Val Arg Glu Ala Arg Ser 
                565                 570                 575     
Gly 
    

<210> 6
<211> 510
<212> DNA
<213> Artificial Sequence


<220> 
<223> High affinity PD1 (soluble) nucleic acid sequence

<400> 6
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg      60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc     120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg     180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc     240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg     300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc     360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca     420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc     480

aggccagccg gccagttcca aaccctggtg                                      510


<210> 7
<211> 684
<212> DNA
<213> Artificial Sequence


<220> 
<223> Human IgG1-Fc; CH2 and CH3 domains of the human IgG1 heavy chain
      and the hinge region.

<400> 7
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc      60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca     120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac     180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac     240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag     300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag     420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg     600

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc     660

ctctccctgt ctccgggtaa atga                                            684


<210> 8
<211> 1200
<212> DNA
<213> Artificial Sequence


<220> 
<223> High affinity soluble PD1-IgG1-Fc fusion gene

<400> 8
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg      60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc     120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg     180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc     240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg     300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc     360

tacctctgtg gggccatctc cctggccccc aagctgcaga tcaaagagag cctgcgggca     420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc     480

aggccagccg gccagttcca aaccctggtg ctcgaggaca aaactcacac atgcccaccg     540

tgcccagcac ctgaactcct ggggggaccg tcagtcttcc tcttcccccc aaaacccaag     600

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     660

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     720

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     780

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     840

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     900

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg     960

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag    1020

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc    1080

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg    1140

cacgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaatga    1200


<210> 9
<211> 17346
<212> DNA
<213> Artificial Sequence


<220> 
<223> vector nucleic acid sequence

<400> 9
cacctaaatt gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag       60

ctcatttttt aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac      120

cgagataggg ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga      180

ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc      240

accctaatca agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg      300

gagcccccga tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa      360

gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac      420

caccacaccc gccgcgctta atgcgccgct acagggcgcg tcccattcgc cattcaggct      480

gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa      540

agggggatgt gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg      600

ttgtaaaacg acggccagtg aattgtaata cgactcacta taggacgaag acaaacaaac      660

cattattatc attaaaaggc tcaggagaaa ctttaacagt aatcaaaatg tctgttacag      720

tcaagagaat cattgacaac acagtcgtag ttccaaaact tcctgcaaat gaggatccag      780

tggaataccc ggcagattac ttcagaaaat caaaggagat tcctctttac atcaatacta      840

caaaaagttt gtcagatcta agaggatatg tctaccaagg cctcaaatcc ggaaatgtat      900

caatcataca tgtcaacagc tacttgtatg gagcattaaa ggacatccgg ggtaagttgg      960

ataaagattg gtcaagtttc ggaataaaca tcgggaaagc aggggataca atcggaatat     1020

ttgaccttgt atccttgaaa gccctggacg gcgtacttcc agatggagta tcggatgctt     1080

ccagaaccag cgcagatgac aaatggttgc ctttgtatct acttggctta tacagagtgg     1140

gcagaacaca aatgcctgaa tacagaaaaa agctcatgga tgggctgaca aatcaatgca     1200

aaatgatcaa tgaacagttt gaacctcttg tgccagaagg tcgtgacatt tttgatgtgt     1260

ggggaaatga cagtaattac acaaaaattg tcgctgcagt ggacatgttc ttccacatgt     1320

tcaaaaaaca tgaatgtgcc tcgttcagat acggaactat tgtttccaga ttcaaagatt     1380

gtgctgcatt ggcaacattt ggacacctct gcaaaataac cggaatgtct acagaagatg     1440

taacgacctg gatcttgaac cgagaagttg cagatgaaat ggtccaaatg atgcttccag     1500

gccaagaaat tgacaaggcc gattcataca tgccttattt gatcgacttt ggattgtctt     1560

ctaagtctcc atattcttcc gtcaaaaacc ctgccttcca cttctggggg caattgacag     1620

ctcttctgct cagatccacc agagcaagga atgcccgaca gcctgatgac attgagtata     1680

catctcttac tacagcaggt ttgttgtacg cttatgcagt aggatcctct gccgacttgg     1740

cacaacagtt ttgtgttgga gataacaaat acactccaga tgatagtacc ggaggattga     1800

cgactaatgc accgccacaa ggcagagatg tggtcgaatg gctcggatgg tttgaagatc     1860

aaaacagaaa accgactcct gatatgatgc agtatgcgaa aagagcagtc atgtcactgc     1920

aaggcctaag agagaagaca attggcaagt atgctaagtc agaatttgac aaatgaccct     1980

ataattctca gatcacctat tatatattat gctacatatg aaaaaaacta acagatatca     2040

tggataatct cacaaaagtt cgtgagtatc tcaagtccta ttctcgtctg gatcaggcgg     2100

taggagagat agatgagatc gaagcacaac gagctgaaaa gtccaattat gagttgttcc     2160

aagaggatgg agtggaagag catactaagc cctcttattt tcaggcagca gatgattctg     2220

acacagaatc tgaaccagaa attgaagaca atcaaggctt gtatgcacca gatccagaag     2280

ctgagcaagt tgaaggcttt atacaggggc ctttagatga ctatgcagat gaggaagtgg     2340

atgttgtatt tacttcggac tggaaacagc ctgagcttga atctgacgag catggaaaga     2400

ccttacggtt gacatcgcca gagggtttaa gtggagagca gaaatcccag tggctttcga     2460

cgattaaagc agtcgtgcaa agtgccaaat actggaatct ggcagagtgc acatttgaag     2520

catcgggaga aggggtcatt atgaaggagc gccagataac tccggatgta tataaggtca     2580

ctccagtgat gaacacacat ccgtcccaat cagaagcagt atcagatgtt tggtctctct     2640

caaagacatc catgactttc caacccaaga aagcaagtct tcagcctctc accatatcct     2700

tggatgaatt gttctcatct agaggagagt tcatctctgt cggaggtgac ggacgaatgt     2760

ctcataaaga ggccatcctg ctcggcctga gatacaaaaa gttgtacaat caggcgagag     2820

tcaaatattc tctgtagact atgaaaaaaa gtaacagata tcacgatcta agtgttatcc     2880

caatccattc atcatgagtt ccttaaagaa gattctcggt ctgaagggga aaggtaagaa     2940

atctaagaaa ttagggatcg caccaccccc ttatgaagag gacactagca tggagtatgc     3000

tccgagcgct ccaattgaca aatcctattt tggagttgac gagatggaca cctatgatcc     3060

gaatcaatta agatatgaga aattcttctt tacagtgaaa atgacggtta gatctaatcg     3120

tccgttcaga acatactcag atgtggcagc cgctgtatcc cattgggatc acatgtacat     3180

cggaatggca gggaaacgtc ccttctacaa aatcttggct tttttgggtt cttctaatct     3240

aaaggccact ccagcggtat tggcagatca aggtcaacca gagtatcacg ctcactgcga     3300

aggcagggct tatttgccac ataggatggg gaagacccct cccatgctca atgtaccaga     3360

gcacttcaga agaccattca atataggtct ttacaaggga acgattgagc tcacaatgac     3420

catctacgat gatgagtcac tggaagcagc tcctatgatc tgggatcatt tcaattcttc     3480

caaattttct gatttcagag agaaggcctt aatgtttggc ctgattgtcg agaaaaaggc     3540

atctggagcg tgggtcctgg actctatcgg ccacttcaaa tgagctagtc taacttctag     3600

cttctgaaca atccccggtt tactcagtct cccctaattc cagcctctcg aacaactaat     3660

atcctgtctt ttctatccct atgaaaaaaa ctaacagaga tcgatctgtt tacgcgtcga     3720

gatgggctcc agaccttcta ccaagaaccc agcacctatg atgctgacta tccgggtcgc     3780

gctggtactg agttgcatct gcccggcaaa ctccattgat ggcaggcctc ttgcagctgc     3840

aggaattgtg gttacaggag acaaagcagt caacatatac acctcatccc agacaggatc     3900

aatcatagtt aagctcctcc cgaatctgcc caaggataag gaggcatgtg cgaaagcccc     3960

cttggatgca tacaacagga cattgaccac tttgctcacc ccccttggtg actctatccg     4020

taggatacaa gagtctgtga ctacatctgg agggcggaga cagaggcgct ttataggcgc     4080

cattattggc ggtgtggctc ttggggttgc aactgccgca caaataacag cggccgcagc     4140

tctgatacaa gccaaacaaa atgctgccaa catcctccga cttaaagaga gcattgccgc     4200

aaccaatgag gctgtgcatg aggtcactga cggattatcg caactagcag tggcagttgg     4260

gaagatgcag cagtttgtta atgaccaatt taataaaaca gctcaggaat tagactgcat     4320

caaaattgca cagcaagttg gtgtagagct caacctgtac ctaaccgaat tgactacagt     4380

attcggacca caaatcactt cacctgcctt aaacaagctg actattcagg cactttacaa     4440

tctagctggt gggaatatgg attacttatt gactaagtta ggtataggga acaatcaact     4500

cagctcatta atcggtagcg gcttaatcac cggtaaccct attctatacg actcacagac     4560

tcaactcttg ggtatacagg taactgcacc ttcagtcggg aacctaaata atatgcgtgc     4620

cacctacttg gaaaccttat ccgtaagcac aaccagggga tttgcctcgg cacttgtccc     4680

aaaagtggtg acacaggtcg gttctgtgat agaagaactt gacacctcat actgtataga     4740

aactgactta gatttatatt gtacaagaat agtaacgttc cctatgtccc ctggtattta     4800

ctcctgcttg agcggcaata catcggcctg tatgtactca aagaccgaag gcgcacttac     4860

tacaccatat atgactatca aaggctcagt catcgctaac tgcaagatga caacatgtag     4920

atgtgtaaac cccccgggta tcatatcgca aaactatgga gaagccgtgt ctctaataga     4980

taaacaatca tgcaatgttt tatccttagg cgggataact ttaaggctca gtggggaatt     5040

cgatgtaact tatcagaaga atatctcaat acaagattct caagtaataa taacaggcaa     5100

tcttgatatc tcaactgagc ttgggaatgt caacaactcg atcagtaatg ctttgaataa     5160

gttagaggaa agcaacagaa aactagacaa agtcaatgtc aaactgacca gcacatctgc     5220

tctcattacc tatatcgttt tgactatcat atctcttgtt tttggtatac ttagcctgat     5280

tctagcatgc tacctaatgt acaagcaaaa ggcgcaacaa aagaccttat tatggcttgg     5340

gaataatacc ctagatcaga tgagagccac tacaaaaatg tgagctagct taattaatat     5400

gaaaaaaact aacagatatc atggaccgcg ccgttagcca agttgcgtta gagaatgatg     5460

aaagagaggc aaaaaataca tggcgcttga tattccggat tgcaatctta ttcttaacag     5520

tagtgacctt ggctatatct gtagcctccc ttttatatag catgggggct agcacaccta     5580

gcgatcttgt aggcataccg actaggattt ccagggcaga agaaaagatt acatctacac     5640

ttggttccaa tcaagatgta gtagatagga tatataagca agtggccctt gagtctccat     5700

tggcattgtt aaatactgag accacaatta tgaacgcaat aacatctctc tcttatcaga     5760

ttaatggagc tgcaaacaac agcgggtggg gggcacctat tcatgaccca gattatatag     5820

gggggatagg caaagaactc attgtagatg atgctagtga tgtcacatca ttctatccct     5880

ctgcatttca agaacatctg aattttatcc cggcgcctac tacaggatca ggttgcactc     5940

gaataccctc atttgacatg agtgctaccc attactgcta cacccataat gtaatattgt     6000

ctggatgcag agatcactca cactcacatc agtatttagc acttggtgtg ctccggacat     6060

ctgcaacagg gagggtattc ttttctactc tgcgttccat caacctggac gacacccaaa     6120

atcggaagtc ttgcagtgtg agtgcaactc ccctgggttg tgatatgctg tgctcgaaag     6180

ccacggagac agaggaagaa gattataact cagctgtccc tacgcggatg gtacatggga     6240

ggttagggtt cgacggccaa tatcacgaaa aggacctaga tgtcacaaca ttattcgggg     6300

actgggtggc caactaccca ggagtagggg gtggatcttt tattgacagc cgcgtatggt     6360

tctcagtcta cggagggtta aaacccaata cacccagtga cactgtacag gaagggaaat     6420

atgtgatata caagcgatac aatgacacat gcccagatga gcaagactac cagattcgaa     6480

tggccaagtc ttcgtataag cctggacggt ttggtgggaa acgcatacag caggctatct     6540

tatctatcaa agtgtcaaca tccttaggcg aagacccggt actgactgta ccgcccaaca     6600

cagtcacact catgggggcc gaaggcagaa ttctcacagt agggacatcc catttcttgt     6660

atcagcgagg gtcatcatac ttctctcccg cgttattata tcctatgaca gtcagcaaca     6720

aaacagccac tcttcatagt ccttatacat tcaatgcctt cactcggcca ggtagtatcc     6780

cttgccaggc ttcagcaaga tgccccaact cgtgtgttac tggagtctat acagatccat     6840

atcccctaat cttctataga aaccacacct tgcgaggggt attcgggaca atgcttgatg     6900

gtgaacaagc aagacttaac cctgcgtctg cagtattcga tagcacatcc cgcagtcgca     6960

taactcgagt gagttcaagc agcatcaaag cagcatacac aacatcaact tgttttaaag     7020

tggtcaagac caataagacc tattgtctca gcattgctga aatatctaat actctcttcg     7080

gagaattcag aatcgtcccg ttactagttg agatcctcaa agatgacggg gttagagaag     7140

ccaggtctgg ctaggtttaa acagctaggc gcgcctatga aaaaaactaa cagcaatcat     7200

gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg gctggcggcc     7260

aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct ccccagccct     7320

gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca acacatcgga     7380

gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca agctggccgc     7440

cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca cacaactgcc     7500

caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca gcggcaccta     7560

cctctgtggg gccatctccc tggcccccaa gctgcagatc aaagagagcc tgcgggcaga     7620

gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc cctcacccag     7680

gccagccggc cagttccaaa ccctggtgct cgaggacaaa actcacacat gcccaccgtg     7740

cccagcacct gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga     7800

caccctcatg atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga     7860

agaccctgag gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac     7920

aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct     7980

gcaccaggac tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc     8040

agcccccatc gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta     8100

caccctgccc ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt     8160

caaaggcttc tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa     8220

caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa     8280

gctcaccgtg gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca     8340

cgaggctctg cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatgacc     8400

tagggctagc ggcctcaatt atatttgagt ttttaatttt tatgaaaaaa actaacagca     8460

atcatggaag tccacgattt tgagaccgac gagttcaatg atttcaatga agatgactat     8520

gccacaagag aattcctgaa tcccgatgag cgcatgacgt acttgaatca tgctgattac     8580

aacctgaatt ctcctctaat tagtgatgat attgacaatt taatcaggaa attcaattct     8640

cttccaattc cctcgatgtg ggatagtaag aactgggatg gagttcttga gatgttaacg     8700

tcatgtcaag ccaatcccat cccaacatct cagatgcata aatggatggg aagttggtta     8760

atgtctgata atcatgatgc cagtcaaggg tatagttttt tacatgaagt ggacaaagag     8820

gcagaaataa catttgacgt ggtggagacc ttcatccgcg gctggggcaa caaaccaatt     8880

gaatacatca aaaaggaaag atggactgac tcattcaaaa ttctcgctta tttgtgtcaa     8940

aagtttttgg acttacacaa gttgacatta atcttaaatg ctgtctctga ggtggaattg     9000

ctcaacttgg cgaggacttt caaaggcaaa gtcagaagaa gttctcatgg aacgaacata     9060

tgcaggatta gggttcccag cttgggtcct acttttattt cagaaggatg ggcttacttc     9120

aagaaacttg atattctaat ggaccgaaac tttctgttaa tggtcaaaga tgtgattata     9180

gggaggatgc aaacggtgct atccatggta tgtagaatag acaacctgtt ctcagagcaa     9240

gacatcttct cccttctaaa tatctacaga attggagata aaattgtgga gaggcaggga     9300

aatttttctt atgacttgat taaaatggtg gaaccgatat gcaacttgaa gctgatgaaa     9360

ttagcaagag aatcaaggcc tttagtccca caattccctc attttgaaaa tcatatcaag     9420

acttctgttg atgaaggggc aaaaattgac cgaggtataa gattcctcca tgatcagata     9480

atgagtgtga aaacagtgga tctcacactg gtgatttatg gatcgttcag acattggggt     9540

catcctttta tagattatta cactggacta gaaaaattac attcccaagt aaccatgaag     9600

aaagatattg atgtgtcata tgcaaaagca cttgcaagtg atttagctcg gattgttcta     9660

tttcaacagt tcaatgatca taaaaagtgg ttcgtgaatg gagacttgct ccctcatgat     9720

catcccttta aaagtcatgt taaagaaaat acatggccca cagctgctca agttcaagat     9780

tttggagata aatggcatga acttccgctg attaaatgtt ttgaaatacc cgacttacta     9840

gacccatcga taatatactc tgacaaaagt cattcaatga ataggtcaga ggtgttgaaa     9900

catgtccgaa tgaatccgaa cactcctatc cctagtaaaa aggtgttgca gactatgttg     9960

gacacaaagg ctaccaattg gaaagaattt cttaaagaga ttgatgagaa gggcttagat    10020

gatgatgatc taattattgg tcttaaagga aaggagaggg aactgaagtt ggcaggtaga    10080

tttttctccc taatgtcttg gaaattgcga gaatactttg taattaccga atatttgata    10140

aagactcatt tcgtccctat gtttaaaggc ctgacaatgg cggacgatct aactgcagtc    10200

attaaaaaga tgttagattc ctcatccggc caaggattga agtcatatga ggcaatttgc    10260

atagccaatc acattgatta cgaaaaatgg aataaccacc aaaggaagtt atcaaacggc    10320

ccagtgttcc gagttatggg ccagttctta ggttatccat ccttaatcga gagaactcat    10380

gaattttttg agaaaagtct tatatactac aatggaagac cagacttgat gcgtgttcac    10440

aacaacacac tgatcaattc aacctcccaa cgagtttgtt ggcaaggaca agagggtgga    10500

ctggaaggtc tacggcaaaa aggatggagt atcctcaatc tactggttat tcaaagagag    10560

gctaaaatca gaaacactgc tgtcaaagtc ttggcacaag gtgataatca agttatttgc    10620

acacagtata aaacgaagaa atcgagaaac gttgtagaat tacagggtgc tctcaatcaa    10680

atggtttcta ataatgagaa aattatgact gcaatcaaaa tagggacagg gaagttagga    10740

cttttgataa atgacgatga gactatgcaa tctgcagatt acttgaatta tggaaaaata    10800

ccgattttcc gtggagtgat tagagggtta gagaccaaga gatggtcacg agtgacttgt    10860

gtcaccaatg accaaatacc cacttgtgct aatataatga gctcagtttc cacaaatgct    10920

ctcaccgtag ctcattttgc tgagaaccca atcaatgcca tgatacagta caattatttt    10980

gggacatttg ctagactctt gttgatgatg catgatcctg ctcttcgtca atcattgtat    11040

gaagttcaag ataagatacc gggcttgcac agttctactt tcaaatacgc catgttgtat    11100

ttggaccctt ccattggagg agtgtcgggc atgtctttgt ccaggttttt gattagagcc    11160

ttcccagatc ccgtaacaga aagtctctca ttctggagat tcatccatgt acatgctcga    11220

agtgagcatc tgaaggagat gagtgcagta tttggaaacc ccgagatagc caagtttcga    11280

ataactcaca tagacaagct agtagaagat ccaacctctc tgaacatcgc tatgggaatg    11340

agtccagcga acttgttaaa gactgaggtt aaaaaatgct taatcgaatc aagacaaacc    11400

atcaggaacc aggtgattaa ggatgcaacc atatatttgt atcatgaaga ggatcggctc    11460

agaagtttct tatggtcaat aaatcctctg ttccctagat ttttaagtga attcaaatca    11520

ggcacttttt tgggagtcgc agacgggctc atcagtctat ttcaaaattc tcgtactatt    11580

cggaactcct ttaagaaaaa gtatcatagg gaattggatg atttgattgt gaggagtgag    11640

gtatcctctt tgacacattt agggaaactt catttgagaa ggggatcatg taaaatgtgg    11700

acatgttcag ctactcatgc tgacacatta agatacaaat cctggggccg tacagttatt    11760

gggacaactg taccccatcc attagaaatg ttgggtccac aacatcgaaa agagactcct    11820

tgtgcaccat gtaacacatc agggttcaat tatgtttctg tgcattgtcc agacgggatc    11880

catgacgtct ttagttcacg gggaccattg cctgcttatc tagggtctaa aacatctgaa    11940

tctacatcta ttttgcagcc ttgggaaagg gaaagcaaag tcccactgat taaaagagct    12000

acacgtctta gagatgctat ctcttggttt gttgaacccg actctaaact agcaatgact    12060

atactttcta acatccactc tttaacaggc gaagaatgga ccaaaaggca gcatgggttc    12120

aaaagaacag ggtctgccct tcataggttt tcgacatctc ggatgagcca tggtgggttc    12180

gcatctcaga gcactgcagc attgaccagg ttgatggcaa ctacagacac catgagggat    12240

ctgggagatc agaatttcga ctttttattc caagcaacgt tgctctatgc tcaaattacc    12300

accactgttg caagagacgg atggatcacc agttgtacag atcattatca tattgcctgt    12360

aagtcctgtt tgagacccat agaagagatc accctggact caagtatgga ctacacgccc    12420

ccagatgtat cccatgtgct gaagacatgg aggaatgggg aaggttcgtg gggacaagag    12480

ataaaacaga tctatccttt agaagggaat tggaagaatt tagcacctgc tgagcaatcc    12540

tatcaagtcg gcagatgtat aggttttcta tatggagact tggcgtatag aaaatctact    12600

catgccgagg acagttctct atttcctcta tctatacaag gtcgtattag aggtcgaggt    12660

ttcttaaaag ggttgctaga cggattaatg agagcaagtt gctgccaagt aatacaccgg    12720

agaagtctgg ctcatttgaa gaggccggcc aacgcagtgt acggaggttt gatttacttg    12780

attgataaat tgagtgtatc acctccattc ctttctctta ctagatcagg acctattaga    12840

gacgaattag aaacgattcc ccacaagatc ccaacctcct atccgacaag caaccgtgat    12900

atgggggtga ttgtcagaaa ttacttcaaa taccaatgcc gtctaattga aaagggaaaa    12960

tacagatcac attattcaca attatggtta ttctcagatg tcttatccat agacttcatt    13020

ggaccattct ctatttccac caccctcttg caaatcctat acaagccatt tttatctggg    13080

aaagataaga atgagttgag agagctggca aatctttctt cattgctaag atcaggagag    13140

gggtgggaag acatacatgt gaaattcttc accaaggaca tattattgtg tccagaggaa    13200

atcagacatg cttgcaagtt cgggattgct aaggataata ataaagacat gagctatccc    13260

ccttggggaa gggaatccag agggacaatt acaacaatcc ctgtttatta tacgaccacc    13320

ccttacccaa agatgctaga gatgcctcca agaatccaaa atcccctgct gtccggaatc    13380

aggttgggcc aattaccaac tggcgctcat tataaaattc ggagtatatt acatggaatg    13440

ggaatccatt acagggactt cttgagttgt ggagacggct ccggagggat gactgctgca    13500

ttactacgag aaaatgtgca tagcagagga atattcaata gtctgttaga attatcaggg    13560

tcagtcatgc gaggcgcctc tcctgagccc cccagtgccc tagaaacttt aggaggagat    13620

aaatcgagat gtgtaaatgg tgaaacatgt tgggaatatc catctgactt atgtgaccca    13680

aggacttggg actatttcct ccgactcaaa gcaggcttgg ggcttcaaat tgatttaatt    13740

gtaatggata tggaagttcg ggattcttct actagcctga aaattgagac gaatgttaga    13800

aattatgtgc accggatttt ggatgagcaa ggagttttaa tctacaagac ttatggaaca    13860

tatatttgtg agagcgaaaa gaatgcagta acaatccttg gtcccatgtt caagacggtc    13920

gacttagttc aaacagaatt tagtagttct caaacgtctg aagtatatat ggtatgtaaa    13980

ggtttgaaga aattaatcga tgaacccaat cccgattggt cttccatcaa tgaatcctgg    14040

aaaaacctgt acgcattcca gtcatcagaa caggaatttg ccagagcaaa gaaggttagt    14100

acatacttta ccttgacagg tattccctcc caattcattc ctgatccttt tgtaaacatt    14160

gagactatgc tacaaatatt cggagtaccc acgggtgtgt ctcatgcggc tgccttaaaa    14220

tcatctgata gacctgcaga tttattgacc attagccttt tttatatggc gattatatcg    14280

tattataaca tcaatcatat cagagtagga ccgatacctc cgaacccccc atcagatgga    14340

attgcacaaa atgtggggat cgctataact ggtataagct tttggctgag tttgatggag    14400

aaagacattc cactatatca acagtgttta gcagttatcc agcaatcatt cccgattagg    14460

tgggaggctg tttcagtaaa aggaggatac aagcagaagt ggagtactag aggtgatggg    14520

ctcccaaaag atacccgaat ttcagactcc ttggccccaa tcgggaactg gatcagatct    14580

ctggaattgg tccgaaacca agttcgtcta aatccattca atgagatctt gttcaatcag    14640

ctatgtcgta cagtggataa tcatttgaaa tggtcaaatt tgcgaagaaa cacaggaatg    14700

attgaatgga tcaatagacg aatttcaaaa gaagaccggt ctatactgat gttgaagagt    14760

gacctacacg aggaaaactc ttggagagat taaaaaatca tgaggagact ccaaacttta    14820

agtatgaaaa aaactttgat ccttaagacc ctcttgtggt ttttattttt tatctggttt    14880

tgtggtcttc gtgggtcggc atggcatctc cacctcctcg cggtccgacc tgggcatccg    14940

aaggaggacg tcgtccactc ggatggctaa gggaggggcc cccgcggggc tgctaacaaa    15000

gcccgaaagg aagctgagtt ggctgctgcc accgctgagc aataactagc ataacccctt    15060

ggggcctcta aacgggtctt gaggggtttt ttgctgaaag gaggaactat atccggatcg    15120

agacctcgat actagtgcgg tggagctcca gcttttgttc cctttagtga gggttaattt    15180

cgagcttggc gtaatcatgg tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa    15240

ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc taatgagtga    15300

gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt    15360

gccagctgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt attgggcgct    15420

cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat    15480

cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac gcaggaaaga    15540

acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt    15600

ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca agtcagaggt    15660

ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc tccctcgtgc    15720

gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa    15780

gcgtggcgct ttctcatagc tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct    15840

ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc ttatccggta    15900

actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca gcagccactg    15960

gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg aagtggtggc    16020

ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg aagccagtta    16080

ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct ggtagcggtg    16140

gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa gaagatcctt    16200

tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg    16260

tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa tgaagtttta    16320

aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg    16380

aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga ctccccgtcg    16440

tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca atgataccgc    16500

gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc ggaagggccg    16560

agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat tgttgccggg    16620

aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc attgctacag    16680

gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt tcccaacgat    16740

caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc    16800

cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg gcagcactgc    16860

ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt gagtactcaa    16920

ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac    16980

gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga aaacgttctt    17040

cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg taacccactc    17100

gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg tgagcaaaaa    17160

caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt tgaatactca    17220

tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc atgagcggat    17280

acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca tttccccgaa    17340

aagtgc                                                               17346


<210> 10
<211> 422
<212> PRT
<213> Artificial Sequence


<220> 
<223> N protein

<400> 10
Met Ser Val Thr Val Lys Arg Ile Ile Asp Asn Thr Val Val Val Pro 
1               5                   10                  15      
Lys Leu Pro Ala Asn Glu Asp Pro Val Glu Tyr Pro Ala Asp Tyr Phe 
            20                  25                  30          
Arg Lys Ser Lys Glu Ile Pro Leu Tyr Ile Asn Thr Thr Lys Ser Leu 
        35                  40                  45              
Ser Asp Leu Arg Gly Tyr Val Tyr Gln Gly Leu Lys Ser Gly Asn Val 
    50                  55                  60                  
Ser Ile Ile His Val Asn Ser Tyr Leu Tyr Gly Ala Leu Lys Asp Ile 
65                  70                  75                  80  
Arg Gly Lys Leu Asp Lys Asp Trp Ser Ser Phe Gly Ile Asn Ile Gly 
                85                  90                  95      
Lys Ala Gly Asp Thr Ile Gly Ile Phe Asp Leu Val Ser Leu Lys Ala 
            100                 105                 110         
Leu Asp Gly Val Leu Pro Asp Gly Val Ser Asp Ala Ser Arg Thr Ser 
        115                 120                 125             
Ala Asp Asp Lys Trp Leu Pro Leu Tyr Leu Leu Gly Leu Tyr Arg Val 
    130                 135                 140                 
Gly Arg Thr Gln Met Pro Glu Tyr Arg Lys Lys Leu Met Asp Gly Leu 
145                 150                 155                 160 
Thr Asn Gln Cys Lys Met Ile Asn Glu Gln Phe Glu Pro Leu Val Pro 
                165                 170                 175     
Glu Gly Arg Asp Ile Phe Asp Val Trp Gly Asn Asp Ser Asn Tyr Thr 
            180                 185                 190         
Lys Ile Val Ala Ala Val Asp Met Phe Phe His Met Phe Lys Lys His 
        195                 200                 205             
Glu Cys Ala Ser Phe Arg Tyr Gly Thr Ile Val Ser Arg Phe Lys Asp 
    210                 215                 220                 
Cys Ala Ala Leu Ala Thr Phe Gly His Leu Cys Lys Ile Thr Gly Met 
225                 230                 235                 240 
Ser Thr Glu Asp Val Thr Thr Trp Ile Leu Asn Arg Glu Val Ala Asp 
                245                 250                 255     
Glu Met Val Gln Met Met Leu Pro Gly Gln Glu Ile Asp Lys Ala Asp 
            260                 265                 270         
Ser Tyr Met Pro Tyr Leu Ile Asp Phe Gly Leu Ser Ser Lys Ser Pro 
        275                 280                 285             
Tyr Ser Ser Val Lys Asn Pro Ala Phe His Phe Trp Gly Gln Leu Thr 
    290                 295                 300                 
Ala Leu Leu Leu Arg Ser Thr Arg Ala Arg Asn Ala Arg Gln Pro Asp 
305                 310                 315                 320 
Asp Ile Glu Tyr Thr Ser Leu Thr Thr Ala Gly Leu Leu Tyr Ala Tyr 
                325                 330                 335     
Ala Val Gly Ser Ser Ala Asp Leu Ala Gln Gln Phe Cys Val Gly Asp 
            340                 345                 350         
Asn Lys Tyr Thr Pro Asp Asp Ser Thr Gly Gly Leu Thr Thr Asn Ala 
        355                 360                 365             
Pro Pro Gln Gly Arg Asp Val Val Glu Trp Leu Gly Trp Phe Glu Asp 
    370                 375                 380                 
Gln Asn Arg Lys Pro Thr Pro Asp Met Met Gln Tyr Ala Lys Arg Ala 
385                 390                 395                 400 
Val Met Ser Leu Gln Gly Leu Arg Glu Lys Thr Ile Gly Lys Tyr Ala 
                405                 410                 415     
Lys Ser Glu Phe Asp Lys 
            420         

<210> 11
<211> 265
<212> PRT
<213> Artificial Sequence


<220> 
<223> P protein

<400> 11
Met Asp Asn Leu Thr Lys Val Arg Glu Tyr Leu Lys Ser Tyr Ser Arg 
1               5                   10                  15      
Leu Asp Gln Ala Val Gly Glu Ile Asp Glu Ile Glu Ala Gln Arg Ala 
            20                  25                  30          
Glu Lys Ser Asn Tyr Glu Leu Phe Gln Glu Asp Gly Val Glu Glu His 
        35                  40                  45              
Thr Lys Pro Ser Tyr Phe Gln Ala Ala Asp Asp Ser Asp Thr Glu Ser 
    50                  55                  60                  
Glu Pro Glu Ile Glu Asp Asn Gln Gly Leu Tyr Ala Pro Asp Pro Glu 
65                  70                  75                  80  
Ala Glu Gln Val Glu Gly Phe Ile Gln Gly Pro Leu Asp Asp Tyr Ala 
                85                  90                  95      
Asp Glu Glu Val Asp Val Val Phe Thr Ser Asp Trp Lys Gln Pro Glu 
            100                 105                 110         
Leu Glu Ser Asp Glu His Gly Lys Thr Leu Arg Leu Thr Ser Pro Glu 
        115                 120                 125             
Gly Leu Ser Gly Glu Gln Lys Ser Gln Trp Leu Ser Thr Ile Lys Ala 
    130                 135                 140                 
Val Val Gln Ser Ala Lys Tyr Trp Asn Leu Ala Glu Cys Thr Phe Glu 
145                 150                 155                 160 
Ala Ser Gly Glu Gly Val Ile Met Lys Glu Arg Gln Ile Thr Pro Asp 
                165                 170                 175     
Val Tyr Lys Val Thr Pro Val Met Asn Thr His Pro Ser Gln Ser Glu 
            180                 185                 190         
Ala Val Ser Asp Val Trp Ser Leu Ser Lys Thr Ser Met Thr Phe Gln 
        195                 200                 205             
Pro Lys Lys Ala Ser Leu Gln Pro Leu Thr Ile Ser Leu Asp Glu Leu 
    210                 215                 220                 
Phe Ser Ser Arg Gly Glu Phe Ile Ser Val Gly Gly Asp Gly Arg Met 
225                 230                 235                 240 
Ser His Lys Glu Ala Ile Leu Leu Gly Leu Arg Tyr Lys Lys Leu Tyr 
                245                 250                 255     
Asn Gln Ala Arg Val Lys Tyr Ser Leu 
            260                 265 

<210> 12
<211> 229
<212> PRT
<213> Artificial Sequence


<220> 
<223> M protein

<400> 12
Met Ser Ser Leu Lys Lys Ile Leu Gly Leu Lys Gly Lys Gly Lys Lys 
1               5                   10                  15      
Ser Lys Lys Leu Gly Ile Ala Pro Pro Pro Tyr Glu Glu Asp Thr Ser 
            20                  25                  30          
Met Glu Tyr Ala Pro Ser Ala Pro Ile Asp Lys Ser Tyr Phe Gly Val 
        35                  40                  45              
Asp Glu Met Asp Thr Tyr Asp Pro Asn Gln Leu Arg Tyr Glu Lys Phe 
    50                  55                  60                  
Phe Phe Thr Val Lys Met Thr Val Arg Ser Asn Arg Pro Phe Arg Thr 
65                  70                  75                  80  
Tyr Ser Asp Val Ala Ala Ala Val Ser His Trp Asp His Met Tyr Ile 
                85                  90                  95      
Gly Met Ala Gly Lys Arg Pro Phe Tyr Lys Ile Leu Ala Phe Leu Gly 
            100                 105                 110         
Ser Ser Asn Leu Lys Ala Thr Pro Ala Val Leu Ala Asp Gln Gly Gln 
        115                 120                 125             
Pro Glu Tyr His Ala His Cys Glu Gly Arg Ala Tyr Leu Pro His Arg 
    130                 135                 140                 
Met Gly Lys Thr Pro Pro Met Leu Asn Val Pro Glu His Phe Arg Arg 
145                 150                 155                 160 
Pro Phe Asn Ile Gly Leu Tyr Lys Gly Thr Ile Glu Leu Thr Met Thr 
                165                 170                 175     
Ile Tyr Asp Asp Glu Ser Leu Glu Ala Ala Pro Met Ile Trp Asp His 
            180                 185                 190         
Phe Asn Ser Ser Lys Phe Ser Asp Phe Arg Glu Lys Ala Leu Met Phe 
        195                 200                 205             
Gly Leu Ile Val Glu Lys Lys Ala Ser Gly Ala Trp Val Leu Asp Ser 
    210                 215                 220                 
Ile Gly His Phe Lys 
225                 

<210> 13
<211> 399
<212> PRT
<213> Artificial Sequence


<220> 
<223> sPD1-Fc protein

<400> 13
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      
Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          
Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              
Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  
Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      
Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         
Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             
Ala Pro Lys Leu Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 
Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 
Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Leu Glu Asp Lys Thr His 
                165                 170                 175     
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            180                 185                 190         
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    210                 215                 220                 
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        275                 280                 285             
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395                 

<210> 14
<211> 2109
<212> PRT
<213> Artificial Sequence


<220> 
<223> L protein

<400> 14
Met Glu Val His Asp Phe Glu Thr Asp Glu Phe Asn Asp Phe Asn Glu 
1               5                   10                  15      
Asp Asp Tyr Ala Thr Arg Glu Phe Leu Asn Pro Asp Glu Arg Met Thr 
            20                  25                  30          
Tyr Leu Asn His Ala Asp Tyr Asn Leu Asn Ser Pro Leu Ile Ser Asp 
        35                  40                  45              
Asp Ile Asp Asn Leu Ile Arg Lys Phe Asn Ser Leu Pro Ile Pro Ser 
    50                  55                  60                  
Met Trp Asp Ser Lys Asn Trp Asp Gly Val Leu Glu Met Leu Thr Ser 
65                  70                  75                  80  
Cys Gln Ala Asn Pro Ile Pro Thr Ser Gln Met His Lys Trp Met Gly 
                85                  90                  95      
Ser Trp Leu Met Ser Asp Asn His Asp Ala Ser Gln Gly Tyr Ser Phe 
            100                 105                 110         
Leu His Glu Val Asp Lys Glu Ala Glu Ile Thr Phe Asp Val Val Glu 
        115                 120                 125             
Thr Phe Ile Arg Gly Trp Gly Asn Lys Pro Ile Glu Tyr Ile Lys Lys 
    130                 135                 140                 
Glu Arg Trp Thr Asp Ser Phe Lys Ile Leu Ala Tyr Leu Cys Gln Lys 
145                 150                 155                 160 
Phe Leu Asp Leu His Lys Leu Thr Leu Ile Leu Asn Ala Val Ser Glu 
                165                 170                 175     
Val Glu Leu Leu Asn Leu Ala Arg Thr Phe Lys Gly Lys Val Arg Arg 
            180                 185                 190         
Ser Ser His Gly Thr Asn Ile Cys Arg Ile Arg Val Pro Ser Leu Gly 
        195                 200                 205             
Pro Thr Phe Ile Ser Glu Gly Trp Ala Tyr Phe Lys Lys Leu Asp Ile 
    210                 215                 220                 
Leu Met Asp Arg Asn Phe Leu Leu Met Val Lys Asp Val Ile Ile Gly 
225                 230                 235                 240 
Arg Met Gln Thr Val Leu Ser Met Val Cys Arg Ile Asp Asn Leu Phe 
                245                 250                 255     
Ser Glu Gln Asp Ile Phe Ser Leu Leu Asn Ile Tyr Arg Ile Gly Asp 
            260                 265                 270         
Lys Ile Val Glu Arg Gln Gly Asn Phe Ser Tyr Asp Leu Ile Lys Met 
        275                 280                 285             
Val Glu Pro Ile Cys Asn Leu Lys Leu Met Lys Leu Ala Arg Glu Ser 
    290                 295                 300                 
Arg Pro Leu Val Pro Gln Phe Pro His Phe Glu Asn His Ile Lys Thr 
305                 310                 315                 320 
Ser Val Asp Glu Gly Ala Lys Ile Asp Arg Gly Ile Arg Phe Leu His 
                325                 330                 335     
Asp Gln Ile Met Ser Val Lys Thr Val Asp Leu Thr Leu Val Ile Tyr 
            340                 345                 350         
Gly Ser Phe Arg His Trp Gly His Pro Phe Ile Asp Tyr Tyr Thr Gly 
        355                 360                 365             
Leu Glu Lys Leu His Ser Gln Val Thr Met Lys Lys Asp Ile Asp Val 
    370                 375                 380                 
Ser Tyr Ala Lys Ala Leu Ala Ser Asp Leu Ala Arg Ile Val Leu Phe 
385                 390                 395                 400 
Gln Gln Phe Asn Asp His Lys Lys Trp Phe Val Asn Gly Asp Leu Leu 
                405                 410                 415     
Pro His Asp His Pro Phe Lys Ser His Val Lys Glu Asn Thr Trp Pro 
            420                 425                 430         
Thr Ala Ala Gln Val Gln Asp Phe Gly Asp Lys Trp His Glu Leu Pro 
        435                 440                 445             
Leu Ile Lys Cys Phe Glu Ile Pro Asp Leu Leu Asp Pro Ser Ile Ile 
    450                 455                 460                 
Tyr Ser Asp Lys Ser His Ser Met Asn Arg Ser Glu Val Leu Lys His 
465                 470                 475                 480 
Val Arg Met Asn Pro Asn Thr Pro Ile Pro Ser Lys Lys Val Leu Gln 
                485                 490                 495     
Thr Met Leu Asp Thr Lys Ala Thr Asn Trp Lys Glu Phe Leu Lys Glu 
            500                 505                 510         
Ile Asp Glu Lys Gly Leu Asp Asp Asp Asp Leu Ile Ile Gly Leu Lys 
        515                 520                 525             
Gly Lys Glu Arg Glu Leu Lys Leu Ala Gly Arg Phe Phe Ser Leu Met 
    530                 535                 540                 
Ser Trp Lys Leu Arg Glu Tyr Phe Val Ile Thr Glu Tyr Leu Ile Lys 
545                 550                 555                 560 
Thr His Phe Val Pro Met Phe Lys Gly Leu Thr Met Ala Asp Asp Leu 
                565                 570                 575     
Thr Ala Val Ile Lys Lys Met Leu Asp Ser Ser Ser Gly Gln Gly Leu 
            580                 585                 590         
Lys Ser Tyr Glu Ala Ile Cys Ile Ala Asn His Ile Asp Tyr Glu Lys 
        595                 600                 605             
Trp Asn Asn His Gln Arg Lys Leu Ser Asn Gly Pro Val Phe Arg Val 
    610                 615                 620                 
Met Gly Gln Phe Leu Gly Tyr Pro Ser Leu Ile Glu Arg Thr His Glu 
625                 630                 635                 640 
Phe Phe Glu Lys Ser Leu Ile Tyr Tyr Asn Gly Arg Pro Asp Leu Met 
                645                 650                 655     
Arg Val His Asn Asn Thr Leu Ile Asn Ser Thr Ser Gln Arg Val Cys 
            660                 665                 670         
Trp Gln Gly Gln Glu Gly Gly Leu Glu Gly Leu Arg Gln Lys Gly Trp 
        675                 680                 685             
Ser Ile Leu Asn Leu Leu Val Ile Gln Arg Glu Ala Lys Ile Arg Asn 
    690                 695                 700                 
Thr Ala Val Lys Val Leu Ala Gln Gly Asp Asn Gln Val Ile Cys Thr 
705                 710                 715                 720 
Gln Tyr Lys Thr Lys Lys Ser Arg Asn Val Val Glu Leu Gln Gly Ala 
                725                 730                 735     
Leu Asn Gln Met Val Ser Asn Asn Glu Lys Ile Met Thr Ala Ile Lys 
            740                 745                 750         
Ile Gly Thr Gly Lys Leu Gly Leu Leu Ile Asn Asp Asp Glu Thr Met 
        755                 760                 765             
Gln Ser Ala Asp Tyr Leu Asn Tyr Gly Lys Ile Pro Ile Phe Arg Gly 
    770                 775                 780                 
Val Ile Arg Gly Leu Glu Thr Lys Arg Trp Ser Arg Val Thr Cys Val 
785                 790                 795                 800 
Thr Asn Asp Gln Ile Pro Thr Cys Ala Asn Ile Met Ser Ser Val Ser 
                805                 810                 815     
Thr Asn Ala Leu Thr Val Ala His Phe Ala Glu Asn Pro Ile Asn Ala 
            820                 825                 830         
Met Ile Gln Tyr Asn Tyr Phe Gly Thr Phe Ala Arg Leu Leu Leu Met 
        835                 840                 845             
Met His Asp Pro Ala Leu Arg Gln Ser Leu Tyr Glu Val Gln Asp Lys 
    850                 855                 860                 
Ile Pro Gly Leu His Ser Ser Thr Phe Lys Tyr Ala Met Leu Tyr Leu 
865                 870                 875                 880 
Asp Pro Ser Ile Gly Gly Val Ser Gly Met Ser Leu Ser Arg Phe Leu 
                885                 890                 895     
Ile Arg Ala Phe Pro Asp Pro Val Thr Glu Ser Leu Ser Phe Trp Arg 
            900                 905                 910         
Phe Ile His Val His Ala Arg Ser Glu His Leu Lys Glu Met Ser Ala 
        915                 920                 925             
Val Phe Gly Asn Pro Glu Ile Ala Lys Phe Arg Ile Thr His Ile Asp 
    930                 935                 940                 
Lys Leu Val Glu Asp Pro Thr Ser Leu Asn Ile Ala Met Gly Met Ser 
945                 950                 955                 960 
Pro Ala Asn Leu Leu Lys Thr Glu Val Lys Lys Cys Leu Ile Glu Ser 
                965                 970                 975     
Arg Gln Thr Ile Arg Asn Gln Val Ile Lys Asp Ala Thr Ile Tyr Leu 
            980                 985                 990         
Tyr His Glu Glu Asp Arg Leu Arg Ser Phe Leu Trp Ser Ile Asn Pro 
        995                 1000                1005            
Leu Phe Pro Arg Phe Leu Ser Glu Phe Lys Ser Gly Thr Phe Leu Gly 
    1010                1015                1020                
Val Ala Asp Gly Leu Ile Ser Leu Phe Gln Asn Ser Arg Thr Ile Arg 
1025                1030                1035                1040
Asn Ser Phe Lys Lys Lys Tyr His Arg Glu Leu Asp Asp Leu Ile Val 
                1045                1050                1055    
Arg Ser Glu Val Ser Ser Leu Thr His Leu Gly Lys Leu His Leu Arg 
            1060                1065                1070        
Arg Gly Ser Cys Lys Met Trp Thr Cys Ser Ala Thr His Ala Asp Thr 
        1075                1080                1085            
Leu Arg Tyr Lys Ser Trp Gly Arg Thr Val Ile Gly Thr Thr Val Pro 
    1090                1095                1100                
His Pro Leu Glu Met Leu Gly Pro Gln His Arg Lys Glu Thr Pro Cys 
1105                1110                1115                1120
Ala Pro Cys Asn Thr Ser Gly Phe Asn Tyr Val Ser Val His Cys Pro 
                1125                1130                1135    
Asp Gly Ile His Asp Val Phe Ser Ser Arg Gly Pro Leu Pro Ala Tyr 
            1140                1145                1150        
Leu Gly Ser Lys Thr Ser Glu Ser Thr Ser Ile Leu Gln Pro Trp Glu 
        1155                1160                1165            
Arg Glu Ser Lys Val Pro Leu Ile Lys Arg Ala Thr Arg Leu Arg Asp 
    1170                1175                1180                
Ala Ile Ser Trp Phe Val Glu Pro Asp Ser Lys Leu Ala Met Thr Ile 
1185                1190                1195                1200
Leu Ser Asn Ile His Ser Leu Thr Gly Glu Glu Trp Thr Lys Arg Gln 
                1205                1210                1215    
His Gly Phe Lys Arg Thr Gly Ser Ala Leu His Arg Phe Ser Thr Ser 
            1220                1225                1230        
Arg Met Ser His Gly Gly Phe Ala Ser Gln Ser Thr Ala Ala Leu Thr 
        1235                1240                1245            
Arg Leu Met Ala Thr Thr Asp Thr Met Arg Asp Leu Gly Asp Gln Asn 
    1250                1255                1260                
Phe Asp Phe Leu Phe Gln Ala Thr Leu Leu Tyr Ala Gln Ile Thr Thr 
1265                1270                1275                1280
Thr Val Ala Arg Asp Gly Trp Ile Thr Ser Cys Thr Asp His Tyr His 
                1285                1290                1295    
Ile Ala Cys Lys Ser Cys Leu Arg Pro Ile Glu Glu Ile Thr Leu Asp 
            1300                1305                1310        
Ser Ser Met Asp Tyr Thr Pro Pro Asp Val Ser His Val Leu Lys Thr 
        1315                1320                1325            
Trp Arg Asn Gly Glu Gly Ser Trp Gly Gln Glu Ile Lys Gln Ile Tyr 
    1330                1335                1340                
Pro Leu Glu Gly Asn Trp Lys Asn Leu Ala Pro Ala Glu Gln Ser Tyr 
1345                1350                1355                1360
Gln Val Gly Arg Cys Ile Gly Phe Leu Tyr Gly Asp Leu Ala Tyr Arg 
                1365                1370                1375    
Lys Ser Thr His Ala Glu Asp Ser Ser Leu Phe Pro Leu Ser Ile Gln 
            1380                1385                1390        
Gly Arg Ile Arg Gly Arg Gly Phe Leu Lys Gly Leu Leu Asp Gly Leu 
        1395                1400                1405            
Met Arg Ala Ser Cys Cys Gln Val Ile His Arg Arg Ser Leu Ala His 
    1410                1415                1420                
Leu Lys Arg Pro Ala Asn Ala Val Tyr Gly Gly Leu Ile Tyr Leu Ile 
1425                1430                1435                1440
Asp Lys Leu Ser Val Ser Pro Pro Phe Leu Ser Leu Thr Arg Ser Gly 
                1445                1450                1455    
Pro Ile Arg Asp Glu Leu Glu Thr Ile Pro His Lys Ile Pro Thr Ser 
            1460                1465                1470        
Tyr Pro Thr Ser Asn Arg Asp Met Gly Val Ile Val Arg Asn Tyr Phe 
        1475                1480                1485            
Lys Tyr Gln Cys Arg Leu Ile Glu Lys Gly Lys Tyr Arg Ser His Tyr 
    1490                1495                1500                
Ser Gln Leu Trp Leu Phe Ser Asp Val Leu Ser Ile Asp Phe Ile Gly 
1505                1510                1515                1520
Pro Phe Ser Ile Ser Thr Thr Leu Leu Gln Ile Leu Tyr Lys Pro Phe 
                1525                1530                1535    
Leu Ser Gly Lys Asp Lys Asn Glu Leu Arg Glu Leu Ala Asn Leu Ser 
            1540                1545                1550        
Ser Leu Leu Arg Ser Gly Glu Gly Trp Glu Asp Ile His Val Lys Phe 
        1555                1560                1565            
Phe Thr Lys Asp Ile Leu Leu Cys Pro Glu Glu Ile Arg His Ala Cys 
    1570                1575                1580                
Lys Phe Gly Ile Ala Lys Asp Asn Asn Lys Asp Met Ser Tyr Pro Pro 
1585                1590                1595                1600
Trp Gly Arg Glu Ser Arg Gly Thr Ile Thr Thr Ile Pro Val Tyr Tyr 
                1605                1610                1615    
Thr Thr Thr Pro Tyr Pro Lys Met Leu Glu Met Pro Pro Arg Ile Gln 
            1620                1625                1630        
Asn Pro Leu Leu Ser Gly Ile Arg Leu Gly Gln Leu Pro Thr Gly Ala 
        1635                1640                1645            
His Tyr Lys Ile Arg Ser Ile Leu His Gly Met Gly Ile His Tyr Arg 
    1650                1655                1660                
Asp Phe Leu Ser Cys Gly Asp Gly Ser Gly Gly Met Thr Ala Ala Leu 
1665                1670                1675                1680
Leu Arg Glu Asn Val His Ser Arg Gly Ile Phe Asn Ser Leu Leu Glu 
                1685                1690                1695    
Leu Ser Gly Ser Val Met Arg Gly Ala Ser Pro Glu Pro Pro Ser Ala 
            1700                1705                1710        
Leu Glu Thr Leu Gly Gly Asp Lys Ser Arg Cys Val Asn Gly Glu Thr 
        1715                1720                1725            
Cys Trp Glu Tyr Pro Ser Asp Leu Cys Asp Pro Arg Thr Trp Asp Tyr 
    1730                1735                1740                
Phe Leu Arg Leu Lys Ala Gly Leu Gly Leu Gln Ile Asp Leu Ile Val 
1745                1750                1755                1760
Met Asp Met Glu Val Arg Asp Ser Ser Thr Ser Leu Lys Ile Glu Thr 
                1765                1770                1775    
Asn Val Arg Asn Tyr Val His Arg Ile Leu Asp Glu Gln Gly Val Leu 
            1780                1785                1790        
Ile Tyr Lys Thr Tyr Gly Thr Tyr Ile Cys Glu Ser Glu Lys Asn Ala 
        1795                1800                1805            
Val Thr Ile Leu Gly Pro Met Phe Lys Thr Val Asp Leu Val Gln Thr 
    1810                1815                1820                
Glu Phe Ser Ser Ser Gln Thr Ser Glu Val Tyr Met Val Cys Lys Gly 
1825                1830                1835                1840
Leu Lys Lys Leu Ile Asp Glu Pro Asn Pro Asp Trp Ser Ser Ile Asn 
                1845                1850                1855    
Glu Ser Trp Lys Asn Leu Tyr Ala Phe Gln Ser Ser Glu Gln Glu Phe 
            1860                1865                1870        
Ala Arg Ala Lys Lys Val Ser Thr Tyr Phe Thr Leu Thr Gly Ile Pro 
        1875                1880                1885            
Ser Gln Phe Ile Pro Asp Pro Phe Val Asn Ile Glu Thr Met Leu Gln 
    1890                1895                1900                
Ile Phe Gly Val Pro Thr Gly Val Ser His Ala Ala Ala Leu Lys Ser 
1905                1910                1915                1920
Ser Asp Arg Pro Ala Asp Leu Leu Thr Ile Ser Leu Phe Tyr Met Ala 
                1925                1930                1935    
Ile Ile Ser Tyr Tyr Asn Ile Asn His Ile Arg Val Gly Pro Ile Pro 
            1940                1945                1950        
Pro Asn Pro Pro Ser Asp Gly Ile Ala Gln Asn Val Gly Ile Ala Ile 
        1955                1960                1965            
Thr Gly Ile Ser Phe Trp Leu Ser Leu Met Glu Lys Asp Ile Pro Leu 
    1970                1975                1980                
Tyr Gln Gln Cys Leu Ala Val Ile Gln Gln Ser Phe Pro Ile Arg Trp 
1985                1990                1995                2000
Glu Ala Val Ser Val Lys Gly Gly Tyr Lys Gln Lys Trp Ser Thr Arg 
                2005                2010                2015    
Gly Asp Gly Leu Pro Lys Asp Thr Arg Ile Ser Asp Ser Leu Ala Pro 
            2020                2025                2030        
Ile Gly Asn Trp Ile Arg Ser Leu Glu Leu Val Arg Asn Gln Val Arg 
        2035                2040                2045            
Leu Asn Pro Phe Asn Glu Ile Leu Phe Asn Gln Leu Cys Arg Thr Val 
    2050                2055                2060                
Asp Asn His Leu Lys Trp Ser Asn Leu Arg Arg Asn Thr Gly Met Ile 
2065                2070                2075                2080
Glu Trp Ile Asn Arg Arg Ile Ser Lys Glu Asp Arg Ser Ile Leu Met 
                2085                2090                2095    
Leu Lys Ser Asp Leu His Glu Glu Asn Ser Trp Arg Asp 
            2100                2105                

<210> 15
<211> 14086
<212> DNA
<213> Artificial Sequence


<220> 
<223> VSV-NDV-HA-sPD1-Fc (nucleotide sequence)

<400> 15
atgtctgtta cagtcaagag aatcattgac aacacagtcg tagttccaaa acttcctgca       60

aatgaggatc cagtggaata cccggcagat tacttcagaa aatcaaagga gattcctctt      120

tacatcaata ctacaaaaag tttgtcagat ctaagaggat atgtctacca aggcctcaaa      180

tccggaaatg tatcaatcat acatgtcaac agctacttgt atggagcatt aaaggacatc      240

cggggtaagt tggataaaga ttggtcaagt ttcggaataa acatcgggaa agcaggggat      300

acaatcggaa tatttgacct tgtatccttg aaagccctgg acggcgtact tccagatgga      360

gtatcggatg cttccagaac cagcgcagat gacaaatggt tgcctttgta tctacttggc      420

ttatacagag tgggcagaac acaaatgcct gaatacagaa aaaagctcat ggatgggctg      480

acaaatcaat gcaaaatgat caatgaacag tttgaacctc ttgtgccaga aggtcgtgac      540

atttttgatg tgtggggaaa tgacagtaat tacacaaaaa ttgtcgctgc agtggacatg      600

ttcttccaca tgttcaaaaa acatgaatgt gcctcgttca gatacggaac tattgtttcc      660

agattcaaag attgtgctgc attggcaaca tttggacacc tctgcaaaat aaccggaatg      720

tctacagaag atgtaacgac ctggatcttg aaccgagaag ttgcagatga aatggtccaa      780

atgatgcttc caggccaaga aattgacaag gccgattcat acatgcctta tttgatcgac      840

tttggattgt cttctaagtc tccatattct tccgtcaaaa accctgcctt ccacttctgg      900

gggcaattga cagctcttct gctcagatcc accagagcaa ggaatgcccg acagcctgat      960

gacattgagt atacatctct tactacagca ggtttgttgt acgcttatgc agtaggatcc     1020

tctgccgact tggcacaaca gttttgtgtt ggagataaca aatacactcc agatgatagt     1080

accggaggat tgacgactaa tgcaccgcca caaggcagag atgtggtcga atggctcgga     1140

tggtttgaag atcaaaacag aaaaccgact cctgatatga tgcagtatgc gaaaagagca     1200

gtcatgtcac tgcaaggcct aagagagaag acaattggca agtatgctaa gtcagaattt     1260

gacaaatgac cctataattc tcagatcacc tattatatat tatgctacat atgaaaaaaa     1320

ctaacagata tcatggataa tctcacaaaa gttcgtgagt atctcaagtc ctattctcgt     1380

ctggatcagg cggtaggaga gatagatgag atcgaagcac aacgagctga aaagtccaat     1440

tatgagttgt tccaagagga tggagtggaa gagcatacta agccctctta ttttcaggca     1500

gcagatgatt ctgacacaga atctgaacca gaaattgaag acaatcaagg cttgtatgca     1560

ccagatccag aagctgagca agttgaaggc tttatacagg ggcctttaga tgactatgca     1620

gatgaggaag tggatgttgt atttacttcg gactggaaac agcctgagct tgaatctgac     1680

gagcatggaa agaccttacg gttgacatcg ccagagggtt taagtggaga gcagaaatcc     1740

cagtggcttt cgacgattaa agcagtcgtg caaagtgcca aatactggaa tctggcagag     1800

tgcacatttg aagcatcggg agaaggggtc attatgaagg agcgccagat aactccggat     1860

gtatataagg tcactccagt gatgaacaca catccgtccc aatcagaagc agtatcagat     1920

gtttggtctc tctcaaagac atccatgact ttccaaccca agaaagcaag tcttcagcct     1980

ctcaccatat ccttggatga attgttctca tctagaggag agttcatctc tgtcggaggt     2040

gacggacgaa tgtctcataa agaggccatc ctgctcggcc tgagatacaa aaagttgtac     2100

aatcaggcga gagtcaaata ttctctgtag actatgaaaa aaagtaacag atatcacgat     2160

ctaagtgtta tcccaatcca ttcatcatga gttccttaaa gaagattctc ggtctgaagg     2220

ggaaaggtaa gaaatctaag aaattaggga tcgcaccacc cccttatgaa gaggacacta     2280

gcatggagta tgctccgagc gctccaattg acaaatccta ttttggagtt gacgagatgg     2340

acacctatga tccgaatcaa ttaagatatg agaaattctt ctttacagtg aaaatgacgg     2400

ttagatctaa tcgtccgttc agaacatact cagatgtggc agccgctgta tcccattggg     2460

atcacatgta catcggaatg gcagggaaac gtcccttcta caaaatcttg gcttttttgg     2520

gttcttctaa tctaaaggcc actccagcgg tattggcaga tcaaggtcaa ccagagtatc     2580

acgctcactg cgaaggcagg gcttatttgc cacataggat ggggaagacc cctcccatgc     2640

tcaatgtacc agagcacttc agaagaccat tcaatatagg tctttacaag ggaacgattg     2700

agctcacaat gaccatctac gatgatgagt cactggaagc agctcctatg atctgggatc     2760

atttcaattc ttccaaattt tctgatttca gagagaaggc cttaatgttt ggcctgattg     2820

tcgagaaaaa ggcatctgga gcgtgggtcc tggactctat cggccacttc aaatgagcta     2880

gtctaacttc tagcttctga acaatccccg gtttactcag tctcccctaa ttccagcctc     2940

tcgaacaact aatatcctgt cttttctatc cctatgaaaa aaactaacag agatcgatct     3000

gtttacgcgt cgagatgggc tccagacctt ctaccaagaa cccagcacct atgatgctga     3060

ctatccgggt cgcgctggta ctgagttgca tctgcccggc aaactccatt gatggcaggc     3120

ctcttgcagc tgcaggaatt gtggttacag gagacaaagc agtcaacata tacacctcat     3180

cccagacagg atcaatcata gttaagctcc tcccgaatct gcccaaggat aaggaggcat     3240

gtgcgaaagc ccccttggat gcatacaaca ggacattgac cactttgctc accccccttg     3300

gtgactctat ccgtaggata caagagtctg tgactacatc tggagggcgg agacagaggc     3360

gctttatagg cgccattatt ggcggtgtgg ctcttggggt tgcaactgcc gcacaaataa     3420

cagcggccgc agctctgata caagccaaac aaaatgctgc caacatcctc cgacttaaag     3480

agagcattgc cgcaaccaat gaggctgtgc atgaggtcac tgacggatta tcgcaactag     3540

cagtggcagt tgggaagatg cagcagtttg ttaatgacca atttaataaa acagctcagg     3600

aattagactg catcaaaatt gcacagcaag ttggtgtaga gctcaacctg tacctaaccg     3660

aattgactac agtattcgga ccacaaatca cttcacctgc cttaaacaag ctgactattc     3720

aggcacttta caatctagct ggtgggaata tggattactt attgactaag ttaggtatag     3780

ggaacaatca actcagctca ttaatcggta gcggcttaat caccggtaac cctattctat     3840

acgactcaca gactcaactc ttgggtatac aggtaactgc accttcagtc gggaacctaa     3900

ataatatgcg tgccacctac ttggaaacct tatccgtaag cacaaccagg ggatttgcct     3960

cggcacttgt cccaaaagtg gtgacacagg tcggttctgt gatagaagaa cttgacacct     4020

catactgtat agaaactgac ttagatttat attgtacaag aatagtaacg ttccctatgt     4080

cccctggtat ttactcctgc ttgagcggca atacatcggc ctgtatgtac tcaaagaccg     4140

aaggcgcact tactacacca tatatgacta tcaaaggctc agtcatcgct aactgcaaga     4200

tgacaacatg tagatgtgta aaccccccgg gtatcatatc gcaaaactat ggagaagccg     4260

tgtctctaat agataaacaa tcatgcaatg ttttatcctt aggcgggata actttaaggc     4320

tcagtgggga attcgatgta acttatcaga agaatatctc aatacaagat tctcaagtaa     4380

taataacagg caatcttgat atctcaactg agcttgggaa tgtcaacaac tcgatcagta     4440

atgctttgaa taagttagag gaaagcaaca gaaaactaga caaagtcaat gtcaaactga     4500

ccagcacatc tgctctcatt acctatatcg ttttgactat catatctctt gtttttggta     4560

tacttagcct gattctagca tgctacctaa tgtacaagca aaaggcgcaa caaaagacct     4620

tattatggct tgggaataat accctagatc agatgagagc cactacaaaa atgtgagcta     4680

gcttaattaa tatgaaaaaa actaacagat atcatggacc gcgccgttag ccaagttgcg     4740

ttagagaatg atgaaagaga ggcaaaaaat acatggcgct tgatattccg gattgcaatc     4800

ttattcttaa cagtagtgac cttggctata tctgtagcct cccttttata tagcatgggg     4860

gctagcacac ctagcgatct tgtaggcata ccgactagga tttccagggc agaagaaaag     4920

attacatcta cacttggttc caatcaagat gtagtagata ggatatataa gcaagtggcc     4980

cttgagtctc cattggcatt gttaaatact gagaccacaa ttatgaacgc aataacatct     5040

ctctcttatc agattaatgg agctgcaaac aacagcgggt ggggggcacc tattcatgac     5100

ccagattata taggggggat aggcaaagaa ctcattgtag atgatgctag tgatgtcaca     5160

tcattctatc cctctgcatt tcaagaacat ctgaatttta tcccggcgcc tactacagga     5220

tcaggttgca ctcgaatacc ctcatttgac atgagtgcta cccattactg ctacacccat     5280

aatgtaatat tgtctggatg cagagatcac tcacactcac atcagtattt agcacttggt     5340

gtgctccgga catctgcaac agggagggta ttcttttcta ctctgcgttc catcaacctg     5400

gacgacaccc aaaatcggaa gtcttgcagt gtgagtgcaa ctcccctggg ttgtgatatg     5460

ctgtgctcga aagccacgga gacagaggaa gaagattata actcagctgt ccctacgcgg     5520

atggtacatg ggaggttagg gttcgacggc caatatcacg aaaaggacct agatgtcaca     5580

acattattcg gggactgggt ggccaactac ccaggagtag ggggtggatc ttttattgac     5640

agccgcgtat ggttctcagt ctacggaggg ttaaaaccca atacacccag tgacactgta     5700

caggaaggga aatatgtgat atacaagcga tacaatgaca catgcccaga tgagcaagac     5760

taccagattc gaatggccaa gtcttcgtat aagcctggac ggtttggtgg gaaacgcata     5820

cagcaggcta tcttatctat caaagtgtca acatccttag gcgaagaccc ggtactgact     5880

gtaccgccca acacagtcac actcatgggg gccgaaggca gaattctcac agtagggaca     5940

tcccatttct tgtatcagcg agggtcatca tacttctctc ccgcgttatt atatcctatg     6000

acagtcagca acaaaacagc cactcttcat agtccttata cattcaatgc cttcactcgg     6060

ccaggtagta tcccttgcca ggcttcagca agatgcccca actcgtgtgt tactggagtc     6120

tatacagatc catatcccct aatcttctat agaaaccaca ccttgcgagg ggtattcggg     6180

acaatgcttg atggtgaaca agcaagactt aaccctgcgt ctgcagtatt cgatagcaca     6240

tcccgcagtc gcataactcg agtgagttca agcagcatca aagcagcata cacaacatca     6300

acttgtttta aagtggtcaa gaccaataag acctattgtc tcagcattgc tgaaatatct     6360

aatactctct tcggagaatt cagaatcgtc ccgttactag ttgagatcct caaagatgac     6420

ggggttagag aagccaggtc tggctaggtt taaacagcta ggcgcgccta tgaaaaaaac     6480

taacagcaat catgcagatc ccacaggcgc cctggccagt cgtctgggcg gtgctacaac     6540

tgggctggcg gccaggatgg ttcttagact ccccagacag gccctggaac ccccccacct     6600

tctccccagc cctgctcgtg gtgaccgaag gggacaacgc caccttcacc tgcagcttct     6660

ccaacacatc ggagagcttc gtgctaaact ggtaccgcat gagccccagc aaccagacgg     6720

acaagctggc cgccttcccc gaggaccgca gccagcccgg ccaggactgc cgcttccgtg     6780

tcacacaact gcccaacggg cgtgacttcc acatgagcgt ggtcagggcc cggcgcaatg     6840

acagcggcac ctacctctgt ggggccatct ccctggcccc caagctgcag atcaaagaga     6900

gcctgcgggc agagctcagg gtgacagaga gaagggcaga agtgcccaca gcccacccca     6960

gcccctcacc caggccagcc ggccagttcc aaaccctggt gctcgaggac aaaactcaca     7020

catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc ctcttccccc     7080

caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc gtggtggtgg     7140

acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc gtggaggtgc     7200

ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt gtggtcagcg     7260

tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc aaggtctcca     7320

acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg cagccccgag     7380

aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac caggtcagcc     7440

tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg gagagcaatg     7500

ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac ggctccttct     7560

tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac gtcttctcat     7620

gctccgtgat gcacgaggct ctgcacaacc actacacgca gaagagcctc tccctgtctc     7680

cgggtaaatg acctagggct agcggcctca attatatttg agtttttaat ttttatgaaa     7740

aaaactaaca gcaatcatgg aagtccacga ttttgagacc gacgagttca atgatttcaa     7800

tgaagatgac tatgccacaa gagaattcct gaatcccgat gagcgcatga cgtacttgaa     7860

tcatgctgat tacaacctga attctcctct aattagtgat gatattgaca atttaatcag     7920

gaaattcaat tctcttccaa ttccctcgat gtgggatagt aagaactggg atggagttct     7980

tgagatgtta acgtcatgtc aagccaatcc catcccaaca tctcagatgc ataaatggat     8040

gggaagttgg ttaatgtctg ataatcatga tgccagtcaa gggtatagtt ttttacatga     8100

agtggacaaa gaggcagaaa taacatttga cgtggtggag accttcatcc gcggctgggg     8160

caacaaacca attgaataca tcaaaaagga aagatggact gactcattca aaattctcgc     8220

ttatttgtgt caaaagtttt tggacttaca caagttgaca ttaatcttaa atgctgtctc     8280

tgaggtggaa ttgctcaact tggcgaggac tttcaaaggc aaagtcagaa gaagttctca     8340

tggaacgaac atatgcagga ttagggttcc cagcttgggt cctactttta tttcagaagg     8400

atgggcttac ttcaagaaac ttgatattct aatggaccga aactttctgt taatggtcaa     8460

agatgtgatt atagggagga tgcaaacggt gctatccatg gtatgtagaa tagacaacct     8520

gttctcagag caagacatct tctcccttct aaatatctac agaattggag ataaaattgt     8580

ggagaggcag ggaaattttt cttatgactt gattaaaatg gtggaaccga tatgcaactt     8640

gaagctgatg aaattagcaa gagaatcaag gcctttagtc ccacaattcc ctcattttga     8700

aaatcatatc aagacttctg ttgatgaagg ggcaaaaatt gaccgaggta taagattcct     8760

ccatgatcag ataatgagtg tgaaaacagt ggatctcaca ctggtgattt atggatcgtt     8820

cagacattgg ggtcatcctt ttatagatta ttacactgga ctagaaaaat tacattccca     8880

agtaaccatg aagaaagata ttgatgtgtc atatgcaaaa gcacttgcaa gtgatttagc     8940

tcggattgtt ctatttcaac agttcaatga tcataaaaag tggttcgtga atggagactt     9000

gctccctcat gatcatccct ttaaaagtca tgttaaagaa aatacatggc ccacagctgc     9060

tcaagttcaa gattttggag ataaatggca tgaacttccg ctgattaaat gttttgaaat     9120

acccgactta ctagacccat cgataatata ctctgacaaa agtcattcaa tgaataggtc     9180

agaggtgttg aaacatgtcc gaatgaatcc gaacactcct atccctagta aaaaggtgtt     9240

gcagactatg ttggacacaa aggctaccaa ttggaaagaa tttcttaaag agattgatga     9300

gaagggctta gatgatgatg atctaattat tggtcttaaa ggaaaggaga gggaactgaa     9360

gttggcaggt agatttttct ccctaatgtc ttggaaattg cgagaatact ttgtaattac     9420

cgaatatttg ataaagactc atttcgtccc tatgtttaaa ggcctgacaa tggcggacga     9480

tctaactgca gtcattaaaa agatgttaga ttcctcatcc ggccaaggat tgaagtcata     9540

tgaggcaatt tgcatagcca atcacattga ttacgaaaaa tggaataacc accaaaggaa     9600

gttatcaaac ggcccagtgt tccgagttat gggccagttc ttaggttatc catccttaat     9660

cgagagaact catgaatttt ttgagaaaag tcttatatac tacaatggaa gaccagactt     9720

gatgcgtgtt cacaacaaca cactgatcaa ttcaacctcc caacgagttt gttggcaagg     9780

acaagagggt ggactggaag gtctacggca aaaaggatgg agtatcctca atctactggt     9840

tattcaaaga gaggctaaaa tcagaaacac tgctgtcaaa gtcttggcac aaggtgataa     9900

tcaagttatt tgcacacagt ataaaacgaa gaaatcgaga aacgttgtag aattacaggg     9960

tgctctcaat caaatggttt ctaataatga gaaaattatg actgcaatca aaatagggac    10020

agggaagtta ggacttttga taaatgacga tgagactatg caatctgcag attacttgaa    10080

ttatggaaaa ataccgattt tccgtggagt gattagaggg ttagagacca agagatggtc    10140

acgagtgact tgtgtcacca atgaccaaat acccacttgt gctaatataa tgagctcagt    10200

ttccacaaat gctctcaccg tagctcattt tgctgagaac ccaatcaatg ccatgataca    10260

gtacaattat tttgggacat ttgctagact cttgttgatg atgcatgatc ctgctcttcg    10320

tcaatcattg tatgaagttc aagataagat accgggcttg cacagttcta ctttcaaata    10380

cgccatgttg tatttggacc cttccattgg aggagtgtcg ggcatgtctt tgtccaggtt    10440

tttgattaga gccttcccag atcccgtaac agaaagtctc tcattctgga gattcatcca    10500

tgtacatgct cgaagtgagc atctgaagga gatgagtgca gtatttggaa accccgagat    10560

agccaagttt cgaataactc acatagacaa gctagtagaa gatccaacct ctctgaacat    10620

cgctatggga atgagtccag cgaacttgtt aaagactgag gttaaaaaat gcttaatcga    10680

atcaagacaa accatcagga accaggtgat taaggatgca accatatatt tgtatcatga    10740

agaggatcgg ctcagaagtt tcttatggtc aataaatcct ctgttcccta gatttttaag    10800

tgaattcaaa tcaggcactt ttttgggagt cgcagacggg ctcatcagtc tatttcaaaa    10860

ttctcgtact attcggaact cctttaagaa aaagtatcat agggaattgg atgatttgat    10920

tgtgaggagt gaggtatcct ctttgacaca tttagggaaa cttcatttga gaaggggatc    10980

atgtaaaatg tggacatgtt cagctactca tgctgacaca ttaagataca aatcctgggg    11040

ccgtacagtt attgggacaa ctgtacccca tccattagaa atgttgggtc cacaacatcg    11100

aaaagagact ccttgtgcac catgtaacac atcagggttc aattatgttt ctgtgcattg    11160

tccagacggg atccatgacg tctttagttc acggggacca ttgcctgctt atctagggtc    11220

taaaacatct gaatctacat ctattttgca gccttgggaa agggaaagca aagtcccact    11280

gattaaaaga gctacacgtc ttagagatgc tatctcttgg tttgttgaac ccgactctaa    11340

actagcaatg actatacttt ctaacatcca ctctttaaca ggcgaagaat ggaccaaaag    11400

gcagcatggg ttcaaaagaa cagggtctgc ccttcatagg ttttcgacat ctcggatgag    11460

ccatggtggg ttcgcatctc agagcactgc agcattgacc aggttgatgg caactacaga    11520

caccatgagg gatctgggag atcagaattt cgacttttta ttccaagcaa cgttgctcta    11580

tgctcaaatt accaccactg ttgcaagaga cggatggatc accagttgta cagatcatta    11640

tcatattgcc tgtaagtcct gtttgagacc catagaagag atcaccctgg actcaagtat    11700

ggactacacg cccccagatg tatcccatgt gctgaagaca tggaggaatg gggaaggttc    11760

gtggggacaa gagataaaac agatctatcc tttagaaggg aattggaaga atttagcacc    11820

tgctgagcaa tcctatcaag tcggcagatg tataggtttt ctatatggag acttggcgta    11880

tagaaaatct actcatgccg aggacagttc tctatttcct ctatctatac aaggtcgtat    11940

tagaggtcga ggtttcttaa aagggttgct agacggatta atgagagcaa gttgctgcca    12000

agtaatacac cggagaagtc tggctcattt gaagaggccg gccaacgcag tgtacggagg    12060

tttgatttac ttgattgata aattgagtgt atcacctcca ttcctttctc ttactagatc    12120

aggacctatt agagacgaat tagaaacgat tccccacaag atcccaacct cctatccgac    12180

aagcaaccgt gatatggggg tgattgtcag aaattacttc aaataccaat gccgtctaat    12240

tgaaaaggga aaatacagat cacattattc acaattatgg ttattctcag atgtcttatc    12300

catagacttc attggaccat tctctatttc caccaccctc ttgcaaatcc tatacaagcc    12360

atttttatct gggaaagata agaatgagtt gagagagctg gcaaatcttt cttcattgct    12420

aagatcagga gaggggtggg aagacataca tgtgaaattc ttcaccaagg acatattatt    12480

gtgtccagag gaaatcagac atgcttgcaa gttcgggatt gctaaggata ataataaaga    12540

catgagctat cccccttggg gaagggaatc cagagggaca attacaacaa tccctgttta    12600

ttatacgacc accccttacc caaagatgct agagatgcct ccaagaatcc aaaatcccct    12660

gctgtccgga atcaggttgg gccaattacc aactggcgct cattataaaa ttcggagtat    12720

attacatgga atgggaatcc attacaggga cttcttgagt tgtggagacg gctccggagg    12780

gatgactgct gcattactac gagaaaatgt gcatagcaga ggaatattca atagtctgtt    12840

agaattatca gggtcagtca tgcgaggcgc ctctcctgag ccccccagtg ccctagaaac    12900

tttaggagga gataaatcga gatgtgtaaa tggtgaaaca tgttgggaat atccatctga    12960

cttatgtgac ccaaggactt gggactattt cctccgactc aaagcaggct tggggcttca    13020

aattgattta attgtaatgg atatggaagt tcgggattct tctactagcc tgaaaattga    13080

gacgaatgtt agaaattatg tgcaccggat tttggatgag caaggagttt taatctacaa    13140

gacttatgga acatatattt gtgagagcga aaagaatgca gtaacaatcc ttggtcccat    13200

gttcaagacg gtcgacttag ttcaaacaga atttagtagt tctcaaacgt ctgaagtata    13260

tatggtatgt aaaggtttga agaaattaat cgatgaaccc aatcccgatt ggtcttccat    13320

caatgaatcc tggaaaaacc tgtacgcatt ccagtcatca gaacaggaat ttgccagagc    13380

aaagaaggtt agtacatact ttaccttgac aggtattccc tcccaattca ttcctgatcc    13440

ttttgtaaac attgagacta tgctacaaat attcggagta cccacgggtg tgtctcatgc    13500

ggctgcctta aaatcatctg atagacctgc agatttattg accattagcc ttttttatat    13560

ggcgattata tcgtattata acatcaatca tatcagagta ggaccgatac ctccgaaccc    13620

cccatcagat ggaattgcac aaaatgtggg gatcgctata actggtataa gcttttggct    13680

gagtttgatg gagaaagaca ttccactata tcaacagtgt ttagcagtta tccagcaatc    13740

attcccgatt aggtgggagg ctgtttcagt aaaaggagga tacaagcaga agtggagtac    13800

tagaggtgat gggctcccaa aagatacccg aatttcagac tccttggccc caatcgggaa    13860

ctggatcaga tctctggaat tggtccgaaa ccaagttcgt ctaaatccat tcaatgagat    13920

cttgttcaat cagctatgtc gtacagtgga taatcatttg aaatggtcaa atttgcgaag    13980

aaacacagga atgattgaat ggatcaatag acgaatttca aaagaagacc ggtctatact    14040

gatgttgaag agtgacctac acgaggaaaa ctcttggaga gattaa                   14086


<210> 16
<211> 16659
<212> DNA
<213> Artificial Sequence


<220> 
<223> Total nucleic acid sequence of rVSV-NDV-sPD1

<400> 16
cacctaaatt gtaagcgtta atattttgtt aaaattcgcg ttaaattttt gttaaatcag       60

ctcatttttt aaccaatagg ccgaaatcgg caaaatccct tataaatcaa aagaatagac      120

cgagataggg ttgagtgttg ttccagtttg gaacaagagt ccactattaa agaacgtgga      180

ctccaacgtc aaagggcgaa aaaccgtcta tcagggcgat ggcccactac gtgaaccatc      240

accctaatca agttttttgg ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg      300

gagcccccga tttagagctt gacggggaaa gccggcgaac gtggcgagaa aggaagggaa      360

gaaagcgaaa ggagcgggcg ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac      420

caccacaccc gccgcgctta atgcgccgct acagggcgcg tcccattcgc cattcaggct      480

gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa      540

agggggatgt gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg      600

ttgtaaaacg acggccagtg aattgtaata cgactcacta taggacgaag acaaacaaac      660

cattattatc attaaaaggc tcaggagaaa ctttaacagt aatcaaaatg tctgttacag      720

tcaagagaat cattgacaac acagtcgtag ttccaaaact tcctgcaaat gaggatccag      780

tggaataccc ggcagattac ttcagaaaat caaaggagat tcctctttac atcaatacta      840

caaaaagttt gtcagatcta agaggatatg tctaccaagg cctcaaatcc ggaaatgtat      900

caatcataca tgtcaacagc tacttgtatg gagcattaaa ggacatccgg ggtaagttgg      960

ataaagattg gtcaagtttc ggaataaaca tcgggaaagc aggggataca atcggaatat     1020

ttgaccttgt atccttgaaa gccctggacg gcgtacttcc agatggagta tcggatgctt     1080

ccagaaccag cgcagatgac aaatggttgc ctttgtatct acttggctta tacagagtgg     1140

gcagaacaca aatgcctgaa tacagaaaaa agctcatgga tgggctgaca aatcaatgca     1200

aaatgatcaa tgaacagttt gaacctcttg tgccagaagg tcgtgacatt tttgatgtgt     1260

ggggaaatga cagtaattac acaaaaattg tcgctgcagt ggacatgttc ttccacatgt     1320

tcaaaaaaca tgaatgtgcc tcgttcagat acggaactat tgtttccaga ttcaaagatt     1380

gtgctgcatt ggcaacattt ggacacctct gcaaaataac cggaatgtct acagaagatg     1440

taacgacctg gatcttgaac cgagaagttg cagatgaaat ggtccaaatg atgcttccag     1500

gccaagaaat tgacaaggcc gattcataca tgccttattt gatcgacttt ggattgtctt     1560

ctaagtctcc atattcttcc gtcaaaaacc ctgccttcca cttctggggg caattgacag     1620

ctcttctgct cagatccacc agagcaagga atgcccgaca gcctgatgac attgagtata     1680

catctcttac tacagcaggt ttgttgtacg cttatgcagt aggatcctct gccgacttgg     1740

cacaacagtt ttgtgttgga gataacaaat acactccaga tgatagtacc ggaggattga     1800

cgactaatgc accgccacaa ggcagagatg tggtcgaatg gctcggatgg tttgaagatc     1860

aaaacagaaa accgactcct gatatgatgc agtatgcgaa aagagcagtc atgtcactgc     1920

aaggcctaag agagaagaca attggcaagt atgctaagtc agaatttgac aaatgaccct     1980

ataattctca gatcacctat tatatattat gctacatatg aaaaaaacta acagatatca     2040

tggataatct cacaaaagtt cgtgagtatc tcaagtccta ttctcgtctg gatcaggcgg     2100

taggagagat agatgagatc gaagcacaac gagctgaaaa gtccaattat gagttgttcc     2160

aagaggatgg agtggaagag catactaagc cctcttattt tcaggcagca gatgattctg     2220

acacagaatc tgaaccagaa attgaagaca atcaaggctt gtatgcacca gatccagaag     2280

ctgagcaagt tgaaggcttt atacaggggc ctttagatga ctatgcagat gaggaagtgg     2340

atgttgtatt tacttcggac tggaaacagc ctgagcttga atctgacgag catggaaaga     2400

ccttacggtt gacatcgcca gagggtttaa gtggagagca gaaatcccag tggctttcga     2460

cgattaaagc agtcgtgcaa agtgccaaat actggaatct ggcagagtgc acatttgaag     2520

catcgggaga aggggtcatt atgaaggagc gccagataac tccggatgta tataaggtca     2580

ctccagtgat gaacacacat ccgtcccaat cagaagcagt atcagatgtt tggtctctct     2640

caaagacatc catgactttc caacccaaga aagcaagtct tcagcctctc accatatcct     2700

tggatgaatt gttctcatct agaggagagt tcatctctgt cggaggtgac ggacgaatgt     2760

ctcataaaga ggccatcctg ctcggcctga gatacaaaaa gttgtacaat caggcgagag     2820

tcaaatattc tctgtagact atgaaaaaaa gtaacagata tcacgatcta agtgttatcc     2880

caatccattc atcatgagtt ccttaaagaa gattctcggt ctgaagggga aaggtaagaa     2940

atctaagaaa ttagggatcg caccaccccc ttatgaagag gacactagca tggagtatgc     3000

tccgagcgct ccaattgaca aatcctattt tggagttgac gagatggaca cctatgatcc     3060

gaatcaatta agatatgaga aattcttctt tacagtgaaa atgacggtta gatctaatcg     3120

tccgttcaga acatactcag atgtggcagc cgctgtatcc cattgggatc acatgtacat     3180

cggaatggca gggaaacgtc ccttctacaa aatcttggct tttttgggtt cttctaatct     3240

aaaggccact ccagcggtat tggcagatca aggtcaacca gagtatcacg ctcactgcga     3300

aggcagggct tatttgccac ataggatggg gaagacccct cccatgctca atgtaccaga     3360

gcacttcaga agaccattca atataggtct ttacaaggga acgattgagc tcacaatgac     3420

catctacgat gatgagtcac tggaagcagc tcctatgatc tgggatcatt tcaattcttc     3480

caaattttct gatttcagag agaaggcctt aatgtttggc ctgattgtcg agaaaaaggc     3540

atctggagcg tgggtcctgg actctatcgg ccacttcaaa tgagctagtc taacttctag     3600

cttctgaaca atccccggtt tactcagtct cccctaattc cagcctctcg aacaactaat     3660

atcctgtctt ttctatccct atgaaaaaaa ctaacagaga tcgatctgtt tacgcgtcga     3720

gatgggctcc agaccttcta ccaagaaccc agcacctatg atgctgacta tccgggtcgc     3780

gctggtactg agttgcatct gcccggcaaa ctccattgat ggcaggcctc ttgcagctgc     3840

aggaattgtg gttacaggag acaaagcagt caacatatac acctcatccc agacaggatc     3900

aatcatagtt aagctcctcc cgaatctgcc caaggataag gaggcatgtg cgaaagcccc     3960

cttggatgca tacaacagga cattgaccac tttgctcacc ccccttggtg actctatccg     4020

taggatacaa gagtctgtga ctacatctgg agggcggaga cagaggcgct ttataggcgc     4080

cattattggc ggtgtggctc ttggggttgc aactgccgca caaataacag cggccgcagc     4140

tctgatacaa gccaaacaaa atgctgccaa catcctccga cttaaagaga gcattgccgc     4200

aaccaatgag gctgtgcatg aggtcactga cggattatcg caactagcag tggcagttgg     4260

gaagatgcag cagtttgtta atgaccaatt taataaaaca gctcaggaat tagactgcat     4320

caaaattgca cagcaagttg gtgtagagct caacctgtac ctaaccgaat tgactacagt     4380

attcggacca caaatcactt cacctgcctt aaacaagctg actattcagg cactttacaa     4440

tctagctggt gggaatatgg attacttatt gactaagtta ggtataggga acaatcaact     4500

cagctcatta atcggtagcg gcttaatcac cggtaaccct attctatacg actcacagac     4560

tcaactcttg ggtatacagg taactgcacc ttcagtcggg aacctaaata atatgcgtgc     4620

cacctacttg gaaaccttat ccgtaagcac aaccagggga tttgcctcgg cacttgtccc     4680

aaaagtggtg acacaggtcg gttctgtgat agaagaactt gacacctcat actgtataga     4740

aactgactta gatttatatt gtacaagaat agtaacgttc cctatgtccc ctggtattta     4800

ctcctgcttg agcggcaata catcggcctg tatgtactca aagaccgaag gcgcacttac     4860

tacaccatat atgactatca aaggctcagt catcgctaac tgcaagatga caacatgtag     4920

atgtgtaaac cccccgggta tcatatcgca aaactatgga gaagccgtgt ctctaataga     4980

taaacaatca tgcaatgttt tatccttagg cgggataact ttaaggctca gtggggaatt     5040

cgatgtaact tatcagaaga atatctcaat acaagattct caagtaataa taacaggcaa     5100

tcttgatatc tcaactgagc ttgggaatgt caacaactcg atcagtaatg ctttgaataa     5160

gttagaggaa agcaacagaa aactagacaa agtcaatgtc aaactgacca gcacatctgc     5220

tctcattacc tatatcgttt tgactatcat atctcttgtt tttggtatac ttagcctgat     5280

tctagcatgc tacctaatgt acaagcaaaa ggcgcaacaa aagaccttat tatggcttgg     5340

gaataatacc ctagatcaga tgagagccac tacaaaaatg tgagctagct taattaatat     5400

gaaaaaaact aacagatatc atggaccgcg ccgttagcca agttgcgtta gagaatgatg     5460

aaagagaggc aaaaaataca tggcgcttga tattccggat tgcaatctta ttcttaacag     5520

tagtgacctt ggctatatct gtagcctccc ttttatatag catgggggct agcacaccta     5580

gcgatcttgt aggcataccg actaggattt ccagggcaga agaaaagatt acatctacac     5640

ttggttccaa tcaagatgta gtagatagga tatataagca agtggccctt gagtctccat     5700

tggcattgtt aaatactgag accacaatta tgaacgcaat aacatctctc tcttatcaga     5760

ttaatggagc tgcaaacaac agcgggtggg gggcacctat tcatgaccca gattatatag     5820

gggggatagg caaagaactc attgtagatg atgctagtga tgtcacatca ttctatccct     5880

ctgcatttca agaacatctg aattttatcc cggcgcctac tacaggatca ggttgcactc     5940

gaataccctc atttgacatg agtgctaccc attactgcta cacccataat gtaatattgt     6000

ctggatgcag agatcactca cactcacatc agtatttagc acttggtgtg ctccggacat     6060

ctgcaacagg gagggtattc ttttctactc tgcgttccat caacctggac gacacccaaa     6120

atcggaagtc ttgcagtgtg agtgcaactc ccctgggttg tgatatgctg tgctcgaaag     6180

ccacggagac agaggaagaa gattataact cagctgtccc tacgcggatg gtacatggga     6240

ggttagggtt cgacggccaa tatcacgaaa aggacctaga tgtcacaaca ttattcgggg     6300

actgggtggc caactaccca ggagtagggg gtggatcttt tattgacagc cgcgtatggt     6360

tctcagtcta cggagggtta aaacccaata cacccagtga cactgtacag gaagggaaat     6420

atgtgatata caagcgatac aatgacacat gcccagatga gcaagactac cagattcgaa     6480

tggccaagtc ttcgtataag cctggacggt ttggtgggaa acgcatacag caggctatct     6540

tatctatcaa agtgtcaaca tccttaggcg aagacccggt actgactgta ccgcccaaca     6600

cagtcacact catgggggcc gaaggcagaa ttctcacagt agggacatcc catttcttgt     6660

atcagcgagg gtcatcatac ttctctcccg cgttattata tcctatgaca gtcagcaaca     6720

aaacagccac tcttcatagt ccttatacat tcaatgcctt cactcggcca ggtagtatcc     6780

cttgccaggc ttcagcaaga tgccccaact cgtgtgttac tggagtctat acagatccat     6840

atcccctaat cttctataga aaccacacct tgcgaggggt attcgggaca atgcttgatg     6900

gtgaacaagc aagacttaac cctgcgtctg cagtattcga tagcacatcc cgcagtcgca     6960

taactcgagt gagttcaagc agcatcaaag cagcatacac aacatcaact tgttttaaag     7020

tggtcaagac caataagacc tattgtctca gcattgctga aatatctaat actctcttcg     7080

gagaattcag aatcgtcccg ttactagttg agatcctcaa agatgacggg gttagagaag     7140

ccaggtctgg ctaggtttaa acagctaggc gcgcctatga aaaaaactaa cagcaatcat     7200

gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg gctggcggcc     7260

aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct ccccagccct     7320

gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca acacatcgga     7380

gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca agctggccgc     7440

cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca cacaactgcc     7500

caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca gcggcaccta     7560

cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc tgcgggcaga     7620

gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc cctcacccag     7680

gccagccggc cagttccaaa ccctggtgta acctagggct agcggcctca attatatttg     7740

agtttttaat ttttatgaaa aaaactaaca gcaatcatgg aagtccacga ttttgagacc     7800

gacgagttca atgatttcaa tgaagatgac tatgccacaa gagaattcct gaatcccgat     7860

gagcgcatga cgtacttgaa tcatgctgat tacaacctga attctcctct aattagtgat     7920

gatattgaca atttaatcag gaaattcaat tctcttccaa ttccctcgat gtgggatagt     7980

aagaactggg atggagttct tgagatgtta acgtcatgtc aagccaatcc catcccaaca     8040

tctcagatgc ataaatggat gggaagttgg ttaatgtctg ataatcatga tgccagtcaa     8100

gggtatagtt ttttacatga agtggacaaa gaggcagaaa taacatttga cgtggtggag     8160

accttcatcc gcggctgggg caacaaacca attgaataca tcaaaaagga aagatggact     8220

gactcattca aaattctcgc ttatttgtgt caaaagtttt tggacttaca caagttgaca     8280

ttaatcttaa atgctgtctc tgaggtggaa ttgctcaact tggcgaggac tttcaaaggc     8340

aaagtcagaa gaagttctca tggaacgaac atatgcagga ttagggttcc cagcttgggt     8400

cctactttta tttcagaagg atgggcttac ttcaagaaac ttgatattct aatggaccga     8460

aactttctgt taatggtcaa agatgtgatt atagggagga tgcaaacggt gctatccatg     8520

gtatgtagaa tagacaacct gttctcagag caagacatct tctcccttct aaatatctac     8580

agaattggag ataaaattgt ggagaggcag ggaaattttt cttatgactt gattaaaatg     8640

gtggaaccga tatgcaactt gaagctgatg aaattagcaa gagaatcaag gcctttagtc     8700

ccacaattcc ctcattttga aaatcatatc aagacttctg ttgatgaagg ggcaaaaatt     8760

gaccgaggta taagattcct ccatgatcag ataatgagtg tgaaaacagt ggatctcaca     8820

ctggtgattt atggatcgtt cagacattgg ggtcatcctt ttatagatta ttacactgga     8880

ctagaaaaat tacattccca agtaaccatg aagaaagata ttgatgtgtc atatgcaaaa     8940

gcacttgcaa gtgatttagc tcggattgtt ctatttcaac agttcaatga tcataaaaag     9000

tggttcgtga atggagactt gctccctcat gatcatccct ttaaaagtca tgttaaagaa     9060

aatacatggc ccacagctgc tcaagttcaa gattttggag ataaatggca tgaacttccg     9120

ctgattaaat gttttgaaat acccgactta ctagacccat cgataatata ctctgacaaa     9180

agtcattcaa tgaataggtc agaggtgttg aaacatgtcc gaatgaatcc gaacactcct     9240

atccctagta aaaaggtgtt gcagactatg ttggacacaa aggctaccaa ttggaaagaa     9300

tttcttaaag agattgatga gaagggctta gatgatgatg atctaattat tggtcttaaa     9360

ggaaaggaga gggaactgaa gttggcaggt agatttttct ccctaatgtc ttggaaattg     9420

cgagaatact ttgtaattac cgaatatttg ataaagactc atttcgtccc tatgtttaaa     9480

ggcctgacaa tggcggacga tctaactgca gtcattaaaa agatgttaga ttcctcatcc     9540

ggccaaggat tgaagtcata tgaggcaatt tgcatagcca atcacattga ttacgaaaaa     9600

tggaataacc accaaaggaa gttatcaaac ggcccagtgt tccgagttat gggccagttc     9660

ttaggttatc catccttaat cgagagaact catgaatttt ttgagaaaag tcttatatac     9720

tacaatggaa gaccagactt gatgcgtgtt cacaacaaca cactgatcaa ttcaacctcc     9780

caacgagttt gttggcaagg acaagagggt ggactggaag gtctacggca aaaaggatgg     9840

agtatcctca atctactggt tattcaaaga gaggctaaaa tcagaaacac tgctgtcaaa     9900

gtcttggcac aaggtgataa tcaagttatt tgcacacagt ataaaacgaa gaaatcgaga     9960

aacgttgtag aattacaggg tgctctcaat caaatggttt ctaataatga gaaaattatg    10020

actgcaatca aaatagggac agggaagtta ggacttttga taaatgacga tgagactatg    10080

caatctgcag attacttgaa ttatggaaaa ataccgattt tccgtggagt gattagaggg    10140

ttagagacca agagatggtc acgagtgact tgtgtcacca atgaccaaat acccacttgt    10200

gctaatataa tgagctcagt ttccacaaat gctctcaccg tagctcattt tgctgagaac    10260

ccaatcaatg ccatgataca gtacaattat tttgggacat ttgctagact cttgttgatg    10320

atgcatgatc ctgctcttcg tcaatcattg tatgaagttc aagataagat accgggcttg    10380

cacagttcta ctttcaaata cgccatgttg tatttggacc cttccattgg aggagtgtcg    10440

ggcatgtctt tgtccaggtt tttgattaga gccttcccag atcccgtaac agaaagtctc    10500

tcattctgga gattcatcca tgtacatgct cgaagtgagc atctgaagga gatgagtgca    10560

gtatttggaa accccgagat agccaagttt cgaataactc acatagacaa gctagtagaa    10620

gatccaacct ctctgaacat cgctatggga atgagtccag cgaacttgtt aaagactgag    10680

gttaaaaaat gcttaatcga atcaagacaa accatcagga accaggtgat taaggatgca    10740

accatatatt tgtatcatga agaggatcgg ctcagaagtt tcttatggtc aataaatcct    10800

ctgttcccta gatttttaag tgaattcaaa tcaggcactt ttttgggagt cgcagacggg    10860

ctcatcagtc tatttcaaaa ttctcgtact attcggaact cctttaagaa aaagtatcat    10920

agggaattgg atgatttgat tgtgaggagt gaggtatcct ctttgacaca tttagggaaa    10980

cttcatttga gaaggggatc atgtaaaatg tggacatgtt cagctactca tgctgacaca    11040

ttaagataca aatcctgggg ccgtacagtt attgggacaa ctgtacccca tccattagaa    11100

atgttgggtc cacaacatcg aaaagagact ccttgtgcac catgtaacac atcagggttc    11160

aattatgttt ctgtgcattg tccagacggg atccatgacg tctttagttc acggggacca    11220

ttgcctgctt atctagggtc taaaacatct gaatctacat ctattttgca gccttgggaa    11280

agggaaagca aagtcccact gattaaaaga gctacacgtc ttagagatgc tatctcttgg    11340

tttgttgaac ccgactctaa actagcaatg actatacttt ctaacatcca ctctttaaca    11400

ggcgaagaat ggaccaaaag gcagcatggg ttcaaaagaa cagggtctgc ccttcatagg    11460

ttttcgacat ctcggatgag ccatggtggg ttcgcatctc agagcactgc agcattgacc    11520

aggttgatgg caactacaga caccatgagg gatctgggag atcagaattt cgacttttta    11580

ttccaagcaa cgttgctcta tgctcaaatt accaccactg ttgcaagaga cggatggatc    11640

accagttgta cagatcatta tcatattgcc tgtaagtcct gtttgagacc catagaagag    11700

atcaccctgg actcaagtat ggactacacg cccccagatg tatcccatgt gctgaagaca    11760

tggaggaatg gggaaggttc gtggggacaa gagataaaac agatctatcc tttagaaggg    11820

aattggaaga atttagcacc tgctgagcaa tcctatcaag tcggcagatg tataggtttt    11880

ctatatggag acttggcgta tagaaaatct actcatgccg aggacagttc tctatttcct    11940

ctatctatac aaggtcgtat tagaggtcga ggtttcttaa aagggttgct agacggatta    12000

atgagagcaa gttgctgcca agtaatacac cggagaagtc tggctcattt gaagaggccg    12060

gccaacgcag tgtacggagg tttgatttac ttgattgata aattgagtgt atcacctcca    12120

ttcctttctc ttactagatc aggacctatt agagacgaat tagaaacgat tccccacaag    12180

atcccaacct cctatccgac aagcaaccgt gatatggggg tgattgtcag aaattacttc    12240

aaataccaat gccgtctaat tgaaaaggga aaatacagat cacattattc acaattatgg    12300

ttattctcag atgtcttatc catagacttc attggaccat tctctatttc caccaccctc    12360

ttgcaaatcc tatacaagcc atttttatct gggaaagata agaatgagtt gagagagctg    12420

gcaaatcttt cttcattgct aagatcagga gaggggtggg aagacataca tgtgaaattc    12480

ttcaccaagg acatattatt gtgtccagag gaaatcagac atgcttgcaa gttcgggatt    12540

gctaaggata ataataaaga catgagctat cccccttggg gaagggaatc cagagggaca    12600

attacaacaa tccctgttta ttatacgacc accccttacc caaagatgct agagatgcct    12660

ccaagaatcc aaaatcccct gctgtccgga atcaggttgg gccaattacc aactggcgct    12720

cattataaaa ttcggagtat attacatgga atgggaatcc attacaggga cttcttgagt    12780

tgtggagacg gctccggagg gatgactgct gcattactac gagaaaatgt gcatagcaga    12840

ggaatattca atagtctgtt agaattatca gggtcagtca tgcgaggcgc ctctcctgag    12900

ccccccagtg ccctagaaac tttaggagga gataaatcga gatgtgtaaa tggtgaaaca    12960

tgttgggaat atccatctga cttatgtgac ccaaggactt gggactattt cctccgactc    13020

aaagcaggct tggggcttca aattgattta attgtaatgg atatggaagt tcgggattct    13080

tctactagcc tgaaaattga gacgaatgtt agaaattatg tgcaccggat tttggatgag    13140

caaggagttt taatctacaa gacttatgga acatatattt gtgagagcga aaagaatgca    13200

gtaacaatcc ttggtcccat gttcaagacg gtcgacttag ttcaaacaga atttagtagt    13260

tctcaaacgt ctgaagtata tatggtatgt aaaggtttga agaaattaat cgatgaaccc    13320

aatcccgatt ggtcttccat caatgaatcc tggaaaaacc tgtacgcatt ccagtcatca    13380

gaacaggaat ttgccagagc aaagaaggtt agtacatact ttaccttgac aggtattccc    13440

tcccaattca ttcctgatcc ttttgtaaac attgagacta tgctacaaat attcggagta    13500

cccacgggtg tgtctcatgc ggctgcctta aaatcatctg atagacctgc agatttattg    13560

accattagcc ttttttatat ggcgattata tcgtattata acatcaatca tatcagagta    13620

ggaccgatac ctccgaaccc cccatcagat ggaattgcac aaaatgtggg gatcgctata    13680

actggtataa gcttttggct gagtttgatg gagaaagaca ttccactata tcaacagtgt    13740

ttagcagtta tccagcaatc attcccgatt aggtgggagg ctgtttcagt aaaaggagga    13800

tacaagcaga agtggagtac tagaggtgat gggctcccaa aagatacccg aatttcagac    13860

tccttggccc caatcgggaa ctggatcaga tctctggaat tggtccgaaa ccaagttcgt    13920

ctaaatccat tcaatgagat cttgttcaat cagctatgtc gtacagtgga taatcatttg    13980

aaatggtcaa atttgcgaag aaacacagga atgattgaat ggatcaatag acgaatttca    14040

aaagaagacc ggtctatact gatgttgaag agtgacctac acgaggaaaa ctcttggaga    14100

gattaaaaaa tcatgaggag actccaaact ttaagtatga aaaaaacttt gatccttaag    14160

accctcttgt ggtttttatt ttttatctgg ttttgtggtc ttcgtgggtc ggcatggcat    14220

ctccacctcc tcgcggtccg acctgggcat ccgaaggagg acgtcgtcca ctcggatggc    14280

taagggaggg gcccccgcgg ggctgctaac aaagcccgaa aggaagctga gttggctgct    14340

gccaccgctg agcaataact agcataaccc cttggggcct ctaaacgggt cttgaggggt    14400

tttttgctga aaggaggaac tatatccgga tcgagacctc gatactagtg cggtggagct    14460

ccagcttttg ttccctttag tgagggttaa tttcgagctt ggcgtaatca tggtcatagc    14520

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca    14580

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct    14640

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac    14700

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc    14760

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt    14820

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg    14880

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg    14940

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat    15000

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta    15060

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct    15120

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc    15180

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa    15240

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg    15300

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag    15360

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt    15420

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta    15480

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc    15540

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca    15600

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa    15660

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat    15720

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct    15780

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt    15840

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat    15900

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta    15960

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg    16020

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt    16080

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg    16140

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg    16200

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc    16260

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa    16320

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac    16380

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt    16440

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg    16500

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa    16560

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata    16620

aacaaatagg ggttccgcgc acatttcccc gaaaagtgc                           16659


<210> 17
<211> 11161
<212> DNA
<213> Vesicular stomatitis Indiana virus


<220> 
<223> VSV Indiana complete genome

<400> 17
acgaagacaa acaaaccatt attatcatta aaaggctcag gagaaacttt aacagtaatc       60

aaaatgtctg ttacagtcaa gagaatcatt gacaacacag tcatagttcc aaaacttcct      120

gcaaatgagg atccagtgga atacccggca gattacttca gaaaatcaaa ggagattcct      180

ctttacatca atactacaaa aagtttgtca gatctaagag gatatgtcta ccaaggcctc      240

aaatccggaa atgtatcaat catacatgtc aacagctact tgtatggagc attaaaggac      300

atccggggta agttggataa agattggtca agtttcggaa taaacatcgg gaaagcaggg      360

gatacaatcg gaatatttga ccttgtatcc ttgaaagccc tggacggcgt acttccagat      420

ggagtatcgg atgcttccag aaccagcgca gatgacaaat ggttgccttt gtatctactt      480

ggcttataca gagtgggcag aacacaaatg cctgaataca gaaaaaagct catggatggg      540

ctgacaaatc aatgcaaaat gatcaatgaa cagtttgaac ctcttgtgcc agaaggtcgt      600

gacatttttg atgtgtgggg aaatgacagt aattacacaa aaattgtcgc tgcagtggac      660

atgttcttcc acatgttcaa aaaacatgaa tgtgcctcgt tcagatacgg aactattgtt      720

tccagattca aagattgtgc tgcattggca acatttggac acctctgcaa aataaccgga      780

atgtctacag aagatgtaac gacctggatc ttgaaccgag aagttgcaga tgaaatggtc      840

caaatgatgc ttccaggcca agaaattgac aaggccgatt catacatgcc ttatttgatc      900

gactttggat tgtcttctaa gtctccatat tcttccgtca aaaaccctgc cttccacttc      960

tgggggcaat tgacagctct tctgctcaga tccaccagag caaggaatgc ccgacagcct     1020

gatgacattg agtatacatc tcttactaca gcaggtttgt tgtacgctta tgcagtagga     1080

tcctctgccg acttggcaca acagttttgt gttggagata acaaatacac tccagatgat     1140

agtaccggag gattgacgac taatgcaccg ccacaaggca gagatgtggt cgaatggctc     1200

ggatggtttg aagatcaaaa cagaaaaccg actcctgata tgatgcagta tgcgaaaaga     1260

gcagtcatgt cactgcaagg cctaagagag aagacaattg gcaagtatgc taagtcagaa     1320

tttgacaaat gaccctataa ttctcagatc acctattata tattatgcta catatgaaaa     1380

aaactaacag atatcatgga taatctcaca aaagttcgtg agtatctcaa gtcctattct     1440

cgtctggatc aggcggtagg agagatagat gagatcgaag cacaacgagc tgaaaagtcc     1500

aattatgagt tgttccaaga ggatggagtg gaagagcata ctaagccctc ttattttcag     1560

gcagcagatg attctgacac agaatctgaa ccagaaattg aagacaatca aggtttgtat     1620

gcacaggatc cagaagctga gcaagttgaa ggctttatac aggggccttt agatgactat     1680

gcagatgagg aagtggatgt tgtatttact tcggactgga aaccacctga gcttgaatct     1740

gacgagcatg gaaagacctt acggttgaca tcgccagagg gtttaagtgg agagcagaaa     1800

tcccagtggc tttcgacgat taaagcagtc gtgcaaagtg ccaaatactg gaatctggca     1860

gagtgcacat ttgaagcatc gggagaaggg gtcattatga aggagcgcca gataactccg     1920

gatgtatata aggtcactcc agtgatgaac acacatccgt cccaatcaga agcagtatca     1980

gatgtttggt ctctctcaaa gacatccatg actttccaac ccaagaaagc aagtcttcag     2040

cctctcacca tatccttgga tgaattgttc tcatctagag gagagttcat ctctgtcgga     2100

ggtgacggac gaatgtctca taaagaggcc atcctgctcg gcctgagata caaaaagttg     2160

tacaatcagg cgagagtcaa atattctctg tagactatga aaaaaagtaa cagatatcac     2220

gatctaagtg ttatcccaat ccattcatca tgagttcctt aaagaagatt ctcggtctga     2280

aggggaaagg taagaaatct aagaaattag ggatcgcacc acccccttat gaagaggaca     2340

ctagcatgga gtatgctccg agcgctccaa ttgacaaatc ctattttgga gttgacgaga     2400

tggacaccta tgatccgaat caattaagat atgagaaatt cttctttaca gtgaaaatga     2460

cggttagatc taatcgtccg ttcagaacat actcagatgt ggcagccgct gtatcccatt     2520

gggatcacat gtacatcgga atggcaggga aacgtccctt ctacaaaatc ttggcttttt     2580

tgggttcttc taatctaaag gccactccag cggtattggc agatcaaggt caaccagagt     2640

atcacactca ctgcgaaggc agggcttatt tgccacatag gatggggaag acccctccca     2700

tgctcaatgt accagagcac ttcagaagac cattcaatat aggtctttac aagggaacga     2760

ttgagctcac aatgaccatc tacgatgatg agtcactgga agcagctcct atgatctggg     2820

atcatttcaa ttcttccaaa ttttctgatt tcagagagaa ggccttaatg tttggcctga     2880

ttgtcgagaa aaaggcatct ggagcgtggg tcctggattc tatcagccac ttcaaatgag     2940

ctagtctaac ttctagcttc tgaacaatcc ccggtttact cagtctctcc taattccagc     3000

ctctcgaaca actaatatcc tgtcttttct atccctatga aaaaaactaa cagagatcga     3060

tctgtttcct tgacactatg aagtgccttt tgtacttagc ctttttattc attggggtga     3120

attgcaagtt caccatagtt tttccacaca accaaaaagg aaactggaaa aatgttcctt     3180

ctaattacca ttattgcccg tcaagctcag atttaaattg gcataatgac ttaataggca     3240

cagccataca agtcaaaatg cccaagagtc acaaggctat tcaagcagac ggttggatgt     3300

gtcatgcttc caaatgggtc actacttgtg atttccgctg gtatggaccg aagtatataa     3360

cacagtccat ccgatccttc actccatctg tagaacaatg caaggaaagc attgaacaaa     3420

cgaaacaagg aacttggctg aatccaggct tccctcctca aagttgtgga tatgcaactg     3480

tgacggatgc cgaagcagtg attgtccagg tgactcctca ccatgtgctg gttgatgaat     3540

acacaggaga atgggttgat tcacagttca tcaacggaaa atgcagcaat tacatatgcc     3600

ccactgtcca taactctaca acctggcatt ctgactataa ggtcaaaggg ctatgtgatt     3660

ctaacctcat ttccatggac atcaccttct tctcagagga cggagagcta tcatccctgg     3720

gaaaggaggg cacagggttc agaagtaact actttgctta tgaaactgga ggcaaggcct     3780

gcaaaatgca atactgcaag cattggggag tcagactccc atcaggtgtc tggttcgaga     3840

tggctgataa ggatctcttt gctgcagcca gattccctga atgcccagaa gggtcaagta     3900

tctctgctcc atctcagacc tcagtggatg taagtctaat tcaggacgtt gagaggatct     3960

tggattattc cctctgccaa gaaacctgga gcaaaatcag agcgggtctt ccaatctctc     4020

cagtggatct cagctatctt gctcctaaaa acccaggaac cggtcctgct ttcaccataa     4080

tcaatggtac cctaaaatac tttgagacca gatacatcag agtcgatatt gctgctccaa     4140

tcctctcaag aatggtcgga atgatcagtg gaactaccac agaaagggaa ctgtgggatg     4200

actgggcacc atatgaagac gtggaaattg gacccaatgg agttctgagg accagttcag     4260

gatataagtt tcctttatac atgattggac atggtatgtt ggactccgat cttcatctta     4320

gctcaaaggc tcaggtgttc gaacatcctc acattcaaga cgctgcttcg caacttcctg     4380

atgatgagag tttatttttt ggtgatactg ggctatccaa aaatccaatc gagcttgtag     4440

aaggttggtt cagtagttgg aaaagctcta ttgcctcttt tttctttatc atagggttaa     4500

tcattggact attcttggtt ctccgagttg gtatccatct ttgcattaaa ttaaagcaca     4560

ccaagaaaag acagatttat acagacatag agatgaaccg acttggaaag taactcaaat     4620

cctgcacaac agattcttca tgtttggacc aaatcaactt gtgataccat gctcaaagag     4680

gcctcaatta tatttgagtt tttaattttt atgaaaaaaa ctaacagcaa tcatggaagt     4740

ccacgatttt gagaccgacg agttcaatga tttcaatgaa gatgactatg ccacaagaga     4800

attcctgaat cccgatgagc gcatgacgta cttgaatcat gctgattaca atttgaattc     4860

tcctctaatt agtgatgata ttgacaattt gatcaggaaa ttcaattctc ttccgattcc     4920

ctcgatgtgg gatagtaaga actgggatgg agttcttgag atgttaacat catgtcaagc     4980

caatcccatc tcaacatctc agatgcataa atggatggga agttggttaa tgtctgataa     5040

tcatgatgcc agtcaagggt atagtttttt acatgaagtg gacaaagagg cagaaataac     5100

atttgacgtg gtggagacct tcatccgcgg ctggggcaac aaaccaattg aatacatcaa     5160

aaaggaaaga tggactgact cattcaaaat tctcgcttat ttgtgtcaaa agtttttgga     5220

cttacacaag ttgacattaa tcttaaatgc tgtctctgag gtggaattgc tcaacttggc     5280

gaggactttc aaaggcaaag tcagaagaag ttctcatgga acgaacatat gcaggattag     5340

ggttcccagc ttgggtccta cttttatttc agaaggatgg gcttacttca agaaacttga     5400

tattctaatg gaccgaaact ttctgttaat ggtcaaagat gtgattatag ggaggatgca     5460

aacggtgcta tccatggtat gtagaataga caacctgttc tcagagcaag acatcttctc     5520

ccttctaaat atctacagaa ttggagataa aattgtggag aggcagggaa atttttctta     5580

tgacttgatt aaaatggtgg aaccgatatg caacttgaag ctgatgaaat tagcaagaga     5640

atcaaggcct ttagtcccac aattccctca ttttgaaaat catatcaaga cttctgttga     5700

tgaaggggca aaaattgacc gaggtataag attcctccat gatcagataa tgagtgtgaa     5760

aacagtggat ctcacactgg tgatttatgg atcgttcaga cattggggtc atccttttat     5820

agattattac actggactag aaaaattaca ttcccaagta accatgaaga aagatattga     5880

tgtgtcatat gcaaaagcac ttgcaagtga tttagctcgg attgttctat ttcaacagtt     5940

caatgatcat aaaaagtggt tcgtgaatgg agacttgctc cctcatgatc atccctttaa     6000

aagtcatgtt aaagaaaata catggcccac agctgctcaa gttcaagatt ttggagataa     6060

atggcatgaa cttccgctga ttaaatgttt tgaaataccc gacttactag acccatcgat     6120

aatatactct gacaaaagtc attcaatgaa taggtcagag gtgttgaaac atgtccgaat     6180

gaatccgaac actcctatcc ctagtaaaaa ggtgttgcag actatgttgg acacaaaggc     6240

taccaattgg aaagaatttc ttaaagagat tgatgagaag ggcttagatg atgatgatct     6300

aattattggt cttaaaggaa aggagaggga actgaagttg gcaggtagat ttttctccct     6360

aatgtcttgg aaattgcgag aatactttgt aattaccgaa tatttgataa agactcattt     6420

cgtccctatg tttaaaggcc tgacaatggc ggacgatcta actgcagtca ttaaaaagat     6480

gttagattcc tcatccggcc aaggattgaa gtcatatgag gcaatttgca tagccaatca     6540

cattgattac gaaaaatgga ataaccacca aaggaagtta tcaaacggcc cagtgttccg     6600

agttatgggc cagttcttag gttatccatc cttaatcgag agaactcatg aattttttga     6660

gaaaagtctt atatactaca atggaagacc agacttgatg cgtgttcaca acaacacact     6720

gatcaattca acctcccaac gagtttgttg gcaaggacaa gagggtggac tggaaggtct     6780

acggcaaaaa ggatggacta tcctcaatct actggttatt caaagagagg ctaaaatcag     6840

aaacactgct gtcaaagtct tggcacaagg tgataatcaa gttatttgca cacagtataa     6900

aacgaagaaa tcgagaaacg ttgtagaatt acagggtgct ctcaatcaaa tggtttctaa     6960

taatgagaaa attatgactg caatcaaaat agggacaggg aagttaggac ttttgataaa     7020

tgacgatgag actatgcaat ctgcagatta cttgaattat ggaaaaatac cgattttccg     7080

tggagtgatt agagggttag agaccaagag atggtcacga gtgacttgtg tcaccaatga     7140

ccaaataccc acttgtgcta atataatgag ctcagtttcc acaaatgctc tcaccgtagc     7200

tcattttgct gagaacccaa tcaatgccat gatacagtac aattattttg ggacatttgc     7260

tagactcttg ttgatgatgc atgatcctgc tcttcgtcaa tcattgtatg aagttcaaga     7320

taagataccg ggcttgcaca gttctacttt caaatacgcc atgttgtatt tggacccttc     7380

cattggagga gtgtcgggca tgtctttgtc caggtttttg attagagcct tcccagatcc     7440

cgtaacagaa agtctctcat tctggagatt catccatgta catgctcgaa gtgagcatct     7500

gaaggagatg agtgcagtat ttggaaaccc cgagatagcc aagtttcgaa taactcacat     7560

agacaagcta gtagaagatc caacctctct gaacatcgct atgggaatga gtccagcgaa     7620

cttgttaaag actgaggtta aaaaatgctt aatcgaatca agacaaacca tcaggaacca     7680

ggtgattaag gatgcaacca tatatttgta tcatgaagag gatcggctca gaagtttctt     7740

atggtcaata aatcctctgt tccctagatt tttaagtgaa ttcaaatcag gcactttttt     7800

gggagtcgca gacgggctca tcagtctatt tcaaaattct cgtactattc ggaactcctt     7860

taagaaaaag tatcataggg aattggatga tttgattgtg aggagtgagg tatcctcttt     7920

gacacattta gggaaacttc atttgagaag gggatcatgt aaaatgtgga catgttcagc     7980

tactcatgct gacacattaa gatacaaatc ctggggccgt acagttattg ggacaactgt     8040

accccatcca ttagaaatgt tgggtccaca acatcgaaaa gagactcctt gtgcaccatg     8100

taacacatca gggttcaatt atgtttctgt gcattgtcca gacgggatcc atgacgtctt     8160

tagttcacgg ggaccattgc ctgcttatct agggtctaaa acatctgaat ctacatctat     8220

tttgcagcct tgggaaaggg aaagcaaagt cccactgatt aaaagagcta cacgtcttag     8280

agatgctatc tcttggtttg ttgaacccga ctctaaacta gcaatgacta tactttctaa     8340

catccactct ttaacaggcg aagaatggac caaaaggcag catgggttca aaagaacagg     8400

gtctgccctt cataggtttt cgacatctcg gatgagccat ggtgggttcg catctcagag     8460

cactgcagca ttgaccaggt tgatggcaac tacagacacc atgagggatc tgggagatca     8520

gaatttcgac tttttattcc aagcaacgtt gctctatgct caaattacca ccactgttgc     8580

aagagacgga tggatcacca gttgtacaga tcattatcat attgcctgta agtcctgttt     8640

gagacccata gaagagatca ccctggactc aagtatggac tacacgcccc cagatgtatc     8700

ccatgtgctg aagacatgga ggaatgggga aggttcgtgg ggacaagaga taaaacagat     8760

ctatccttta gaagggaatt ggaagaattt agcacctgct gagcaatcct atcaagtcgg     8820

cagatgtata ggttttctat atggagactt ggcgtataga aaatctactc atgccgagga     8880

cagttctcta tttcctctat ctatacaagg tcgtattaga ggtcgaggtt tcttaaaagg     8940

gttgctagac ggattaatga gagcaagttg ctgccaagta atacaccgga gaagtctggc     9000

tcatttgaag aggccggcca acgcagtgta cggaggtttg atttacttga ttgataaatt     9060

gagtgtatca cctccattcc tttctcttac tagatcagga cctattagag acgaattaga     9120

aacgattccc cacaagatcc caacctccta tccgacaagc aaccgtgata tgggggtgat     9180

tgtcagaaat tacttcaaat accaatgccg tctaattgaa aagggaaaat acagatcaca     9240

ttattcacaa ttatggttat tctcagatgt cttatccata gacttcattg gaccattctc     9300

tatttccacc accctcttgc aaatcctata caagccattt ttatctggga aagataagaa     9360

tgagttgaga gagctggcaa atctttcttc attgctaaga tcaggagagg ggtgggaaga     9420

catacatgtg aaattcttca ccaaggacat attattgtgt ccagaggaaa tcagacatgc     9480

ttgcaagttc gggattgcta aggataataa taaagacatg agctatcccc cttggggaag     9540

ggaatccaga gggacaatta caacaatccc tgtttattat acgaccaccc cttacccaaa     9600

gatgctagag atgcctccaa gaatccaaaa tcccctgctg tccggaatca ggttgggcca     9660

attaccaact ggcgctcatt ataaaattcg gagtatatta catggaatgg gaatccatta     9720

cagggacttc ttgagttgtg gagacggctc cggagggatg actgctgcat tactacgaga     9780

aaatgtgcat agcagaggaa tattcaatag tctgttagaa ttatcagggt cagtcatgcg     9840

aggcgcctct cctgagcccc ccagtgccct agaaacttta ggaggagata aatcgagatg     9900

tgtaaatggt gaaacatgtt gggaatatcc atctgactta tgtgacccaa ggacttggga     9960

ctatttcctc cgactcaaag caggcttggg gcttcaaatt gatttaattg taatggatat    10020

ggaagttcgg gattcttcta ctagcctgaa aattgagacg aatgttagaa attatgtgca    10080

ccggattttg gatgagcaag gagttttaat ctacaagact tatggaacat atatttgtga    10140

gagcgaaaag aatgcagtaa caatccttgg tcccatgttc aagacggtcg acttagttca    10200

aacagaattt agtagttctc aaacgtctga agtatatatg gtatgtaaag gtttgaagaa    10260

attaatcgat gaacccaatc ccgattggtc ttccatcaat gaatcctgga aaaacctgta    10320

cgcattccag tcatcagaac aggaatttgc cagagcaaag aaggttagta catactttac    10380

cttgacaggt attccctccc aattcattcc tgatcctttt gtaaacattg agactatgct    10440

acaaatattc ggagtaccca cgggtgtgtc tcatgcggct gccttaaaat catctgatag    10500

acctgcagat ttattgacca ttagcctttt ttatatggcg attatatcgt attataacat    10560

caatcatatc agagtaggac cgatacctcc gaacccccca tcagatggaa ttgcacaaaa    10620

tgtggggatc gctataactg gtataagctt ttggctgagt ttgatggaga aagacattcc    10680

actatatcaa cagtgtttag cagttatcca gcaatcattc ccgattaggt gggaggctgt    10740

ttcagtaaaa ggaggataca agcagaagtg gagtactaga ggtgatgggc tcccaaaaga    10800

tacccgaact tcagactcct tggccccaat cgggaactgg atcagatctc tggaattggt    10860

ccgaaaccaa gttcgtctaa atccattcaa tgagatcttg ttcaatcagc tatgtcgtac    10920

agtggataat catttgaaat ggtcaaattt gcgaagaaac acaggaatga ttgaatggat    10980

caatagacga atttcaaaag aagaccggtc tatactgatg ttgaagagtg acctacacga    11040

ggaaaactct tggagagatt aaaaaatcat gaggagactc caaactttaa gtatgaaaaa    11100

aactttgatc cttaagaccc tcttgtggtt tttatttttt atctggtttt gtggtcttcg    11160

t                                                                    11161


<210> 18
<211> 511
<212> PRT
<213> Vesicular stomatitis Indiana virus


<220> 
<223> VSV Indiana G protein

<400> 18
Met Lys Cys Phe Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      
Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          
Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              
His Asn Asp Leu Ile Gly Thr Gly Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  
His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  
Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      
Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         
Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             
Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 
Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 
Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Asp Ile Cys Pro Thr 
                165                 170                 175     
Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         
Cys Asp Ser Asn Leu Ile Ser Thr Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             
Arg Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 
Tyr Phe Ala Tyr Glu Thr Gly Asp Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 
Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     
Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         
Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             
Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 
Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 
Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     
Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         
Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             
Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 
Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 
Tyr Met Ile Gly His Gly Met Leu Asp Ser Gly Leu His Leu Ser Ser 
                405                 410                 415     
Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         
Leu Pro Asp Asp Glu Ile Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             
Asn Pro Ile Asp Phe Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 
Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 
Val Leu Arg Val Gly Ile Tyr Leu Tyr Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     
Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Arg 
            500                 505                 510     

<210> 19
<211> 1992
<212> DNA
<213> Newcastle disease virus


<220> 
<223> NDV HN protein (nucleic acid sequence)

<400> 19
acgggtagaa cggtaagaga ggccgcccct caattgcgag ccagacttca caacctccgt      60

tctaccgctt caccgacaac agtcctcaat catggaccgc gccgttagcc aagttgcgtt     120

agagaatgat gaaagagagg caaaaaatac atggcgcttg atattccgga ttgcaatctt     180

attcttaaca gtagtgacct tggctatatc tgtagcctcc cttttatata gcatgggggc     240

tagcacacct agcgatcttg taggcatacc gactaggatt tccagggcag aagaaaagat     300

tacatctaca cttggttcca atcaagatgt agtagatagg atatataagc aagtggccct     360

tgagtctcca ttggcattgt taaatactga gaccacaatt atgaacgcaa taacatctct     420

ctcttatcag attaatggag ctgcaaacaa cagcgggtgg ggggcaccta ttcatgaccc     480

agattatata ggggggatag gcaaagaact cattgtagat gatgctagtg atgtcacatc     540

attctatccc tctgcatttc aagaacatct gaattttatc ccggcgccta ctacaggatc     600

aggttgcact cgaataccct catttgacat gagtgctacc cattactgct acacccataa     660

tgtaatattg tctggatgca gagatcactc acactcatat cagtatttag cacttggtgt     720

gctccggaca tctgcaacag ggagggtatt cttttctact ctgcgttcca tcaacctgga     780

cgacacccaa aatcggaagt cttgcagtgt gagtgcaact cccctgggtt gtgatatgct     840

gtgctcgaaa gccacggaga cagaggaaga agattataac tcagctgtcc ctacgcggat     900

ggtacatggg aggttagggt tcgacggcca atatcacgaa aaggacctag atgtcacaac     960

attattcggg gactgggtgg ccaactaccc aggagtaggg ggtggatctt ttattgacag    1020

ccgcgtatgg ttctcagtct acggagggtt aaaacccaat tcacccagtg acactgtaca    1080

ggaagggaaa tatgtgatat acaagcgata caatgacaca tgcccagatg agcaagacta    1140

ccagattcga atggccaagt cttcgtataa gcctggacgg tttggtggga aacgcataca    1200

gcaggctatc ttatctatca aagtgtcaac atccttaggc gaagacccgg tactgactgt    1260

accgcccaac acagtcacac tcatgggggc cgaaggcaga attctcacag tagggacatc    1320

ccatttcttg tatcagcgag ggtcatcata cttctctccc gcgttattat atcctatgac    1380

agtcagcaac aaaacagcca ctcttcatag tccttataca ttcaatgcct tcactcggcc    1440

aggtagtatc ccttgccagg cttcagcaag atgccccaac tcgtgtgtta ctggagtcta    1500

tacagatcca tatcccctaa tcttctatag aaaccacacc ttgcgagggg tattcgggac    1560

aatgcttgat ggtgaacaag caagacttaa ccctgcgtct gcagtattcg atagcacatc    1620

ccgcagtcgc ataactcgag tgagttcaag cagcatcaaa gcagcataca caacatcaac    1680

ttgttttaaa gtggtcaaga ccaataagac ctattgtctc agcattgctg aaatatctaa    1740

tactctcttc ggagaattca gaatcgtccc gttactagtt gagatcctca aagatgacgg    1800

ggttagagaa gccaggtctg gctagttgag tcaactatga aagagttgga aagatggcat    1860

tgtatcacct atcttctgcg acatcaagaa tcaaaccgaa tgccggcgcg tgctcgaatt    1920

ccatgtcgcc agttgaccac aatcagccag tgctcatgcg atcagattaa gccttgtcaa    1980

tagtctcttg at                                                        1992


<210> 20
<211> 15186
<212> DNA
<213> Newcastle disease virus


<220> 
<223> NDV Hitchner B1 complete genome

<400> 20
accaaacaga gaatccgtaa gttacgataa aaggcgaagg agcaattgaa gtcgcacggg       60

tagaaggtgt gaatctcgag tgcgagcccg aagcacaaac tcgaggaagc cttctgccaa      120

catgtcttcc gtattcgacg agtacgaaca gctcctcgcg gctcagactc gccccaatgg      180

agctcatgga gggggggaga aagggagtac cttaaaagta gacgtcccgg tattcactct      240

taacagtgat gacccagaag ataggtggag ctttgtggta ttctgcctcc ggattgctgt      300

tagcgaagat gccaacaaac cactcaggca aggtgctctc atatctcttt tatgctccca      360

ctcacaggta atgaggaacc atgttgccct tgcagggaaa cagaatgaag ccacattggc      420

cgtgcttgag attgatggct ttgccaacgg cacgccccag ttcaacaata ggagtggagt      480

gtctgaagag agagcacaga gatttgcgat gatagcagga tctctccctc gggcatgcag      540

caacggcacc ccgttcgtca cagccggggc tgaagatgat gcaccagaag acatcaccga      600

taccctggag aggatcctct ctatccaggc tcaagtatgg gtcacagtag caaaagccat      660

gactgcgtat gagactgcag atgagtcgga aacaaggcga atcaataagt atatgcagca      720

aggcagggtc caaaagaaat acatcctcta ccccgtatgc aggagcacaa tccaactcac      780

gatcagacag tctcttgcag tccgcatctt tttggttagc gagctcaaga gaggccgcaa      840

cacggcaggt ggtacctcta cttattataa cctagtaggg gacgtagact catatatcag      900

gaataccggg cttactgcat tcttcttgac actcaagtac ggaatcaaca ccaagacatc      960

agcccttgca cttagtagcc tctcaggcga catccagaag atgaagcagc tcatgcgttt     1020

gtatcggatg aaaggagata atgcgccgta catgacatta cttggtgata gtgaccagat     1080

gagctttgcg cctgccgagt atgcacaact ttactccttt gccatgggta tggcatcagt     1140

cctagataaa ggtactggga aataccaatt tgccagggac tttatgagca catcattctg     1200

gagacttgga gtagagtacg ctcaggctca gggaagtagc attaacgagg atatggctgc     1260

cgagctaaag ctaaccccgg cagcaaggag gggcctggca gctgctgccc aacgagtctc     1320

cgaggtgacc agcagcatag acatgcctac tcaacaagtc ggagtcctca ctgggcttag     1380

cgagggggga tcccaagccc tacaaggcgg atcgaataga tcgcaagggc aaccagaagc     1440

cggggatggg gagacccaat tcctggatct gatgagagcg gtagcaaata gcatgaggga     1500

ggcgccaaac tctgcacagg gcactcccca atcggggcct cccccaactc ctgggccatc     1560

ccaagataac gacaccgact gggggtattg attgacaaaa cccagcctgc ttctacaaga     1620

acatcccaat gctctcaccc gtagtcgacc cctcgatttg cggctctata tgaccacacc     1680

ctcaaacaaa catccccctc tttcctccct ccccctgctg tacaactccg cacgccctag     1740

ataccacagg cacaccgcgg ctcactaaca atcaaaacag agccgaggga attagaaaaa     1800

agtacgggta gaagagggat attcagagat cagggcaagt ctcccgagtc tctgctctct     1860

cctctacctg atagaccagg acaaacatgg ccacctttac agatgcagag atcgacgagc     1920

tatttgagac aagtggaact gtcattgaca acataattac agcccagggt aaaccagcag     1980

agactgttgg aaggagtgca atcccacagg gcaagaccaa ggtgctgagc gcagcatggg     2040

agaagcatgg gagcatccag ccaccggcca gtcaagacaa cctcgatcga caggacagat     2100

ctgacaaaca accatccaca cccgagcaaa cgaccccgca cgacagcccg ccggccacat     2160

ccgctgacca gccccccacc caggccacag acgaagccgt cgacacacag ctcaggaccg     2220

gagcaagcaa ctctctgctg ttgatgcttg acaagctcag caataaatcg tccaatgcta     2280

aaaagggccc atggtcgagc ccccaagagg ggaatcacca acgtccgact caacagcagg     2340

ggagtcaacc cagtcgcgga aacagccagg aaagactgca gaaccaagtc aaggccgccc     2400

ctggaaacca gggcacagac gtgaacacag catatcatgg acaatgggag gagtcacaac     2460

tatcagctgg tgcaacccct catgctctcc gatcaaggca gagccaagac aatacccttg     2520

tatctgcgga tcatgtccag ccacctgtag actttgtgca agcgatgatg tctatgatgg     2580

gggcgatatc acagagagta agtaaggttg actatcagct agatcttgtc ttgaaacaga     2640

catcctccat ccctatgatg cggtccgaaa tccaacagct gaaaacatct gttgcagtca     2700

tggaagccaa cttgggaatg atgaagattc tggatcccgg ttgtgccaac atttcatctc     2760

tgagtgatct acgggcagtt gcccgatctc acccggtttt agtttcaggc cctggagacc     2820

catctcccta tgtgatacaa ggaggcgaaa tggcacttaa taaactttcg caaccagtgc     2880

cacatccatc tgaattgatt aaacccgcca ctgcatgcgg gcctgatata ggagtggaga     2940

gggacactgt ccgtgcattg atcatgtcac gcccaatgca cccgagttct tcagccaagc     3000

tcctaagcaa gttagatgca gccgggtcga tcgaggaaat caggaaaatc aagcgccttg     3060

ctctaaatgg ctaattacta ctgccacacg tagcgggtcc ctgtccactc ggcatcacac     3120

ggaatctgca ccgagttccc ccccgcagac ccaaggtcca actctagaag cggcaatcct     3180

ctctcgcttc ctcagcccca ctgaatgatc gcgtaaccgt aattaatcta gctacattaa     3240

ggattaagaa aaaatacggg tagaattgga gtgccccaat tgtgccaaga tggactcatc     3300

taggacaatt gggctgtact ttgattctgc ccattcttct agcaacctgt tagcatttcc     3360

gatcgtccta caagacacag gagatgggaa gaagcaaatc gccccgcaat ataggatcca     3420

gcgccttgac tcgtggactg atagtaagga agactcagta ttcatcacca cctatggatt     3480

catctttcaa gttgggaatg aggaagccac tgtcggcatg atcgatgata aacccaagcg     3540

cgagttactt tccgctgcga tgctctgcct aggaagcgtc ccaaataccg gagaccttgt     3600

tgagctggca agggcctgtc tcactatgat ggtcacatgc aagaagagtg caactaatac     3660

tgagagaatg gttttctcag tagtgcaggc accccaagtg ctgcaaagct gtagggttgt     3720

ggcaaataaa tactcatcag tgaatgcagt caagcacgtg aaagcgccag agaagatccc     3780

cgggagtgga accctagaat acaaggtgaa ctttgtctcc ttgactgtgg taccgaagaa     3840

ggatgtctac aagatcccag ctgcagtatt gaagatttct ggctcgagtc tgtacaatct     3900

tgcgctcaat gtcactatta atgtggaggt agacccgagg agtcctttgg ttaaatctct     3960

gtctaagtct gacagcggat actatgctaa cctcttcttg catattggac ttatgaccac     4020

cgtagatagg aaggggaaga aagtgacatt tgacaagctg gaaaagaaaa taaggagcct     4080

tgatctatct gtcgggctca gtgatgtgct cgggccttcc gtgttggtaa aagcaagagg     4140

tgcacggact aagcttttgg cacctttctt ctctagcagt gggacagcct gctatcccat     4200

agcaaatgct tctcctcagg tggccaagat actctggagt caaaccgcgt gcctgcggag     4260

cgttaaaatc attatccaag caggtaccca acgcgctgtc gcagtgaccg ctgaccacga     4320

ggttacctct actaagctgg agaaggggca cacccttgcc aaatacaatc cttttaagaa     4380

ataagctgcg tctctgagat tgcgctccgc ccactcaccc agatcatcat gacacaaaaa     4440

actaatctgt cttgattatt tacagttagt ttacctgtcc atcaagttag aaaaaacacg     4500

ggtagaagat tctggatccc ggttggcgcc ctccaggtgc aggatgggct ccagaccttc     4560

taccaagaac ccagcaccta tgatgctgac tatccgggtc gcgctggtac tgagttgcat     4620

ctgcccggca aactccattg atggcaggcc tcttgcagct gcaggaattg tggttacagg     4680

agacaaagca gtcaacatat acacctcatc ccagacagga tcaatcatag ttaagctcct     4740

cccgaatctg cccaaggata aggaggcatg tgcgaaagcc cccttggatg catacaacag     4800

gacattgacc actttgctca ccccccttgg tgactctatc cgtaggatac aagagtctgt     4860

gactacatct ggagggggga gacaggggcg ccttataggc gccattattg gcggtgtggc     4920

tcttggggtt gcaactgccg cacaaataac agcggccgca gctctgatac aagccaaaca     4980

aaatgctgcc aacatcctcc gacttaaaga gagcattgcc gcaaccaatg aggctgtgca     5040

tgaggtcact gacggattat cgcaactagc agtggcagtt gggaagatgc agcagtttgt     5100

taatgaccaa tttaataaaa cagctcagga attagactgc atcaaaattg cacagcaagt     5160

tggtgtagag ctcaacctgt acctaaccga attgactaca gtattcggac cacaaatcac     5220

ttcacctgcc ttaaacaagc tgactattca ggcactttac aatctagctg gtgggaatat     5280

ggattactta ttgactaagt taggtatagg gaacaatcaa ctcagctcat taatcggtag     5340

cggcttaatc accggtaacc ctattctata cgactcacag actcaactct tgggtataca     5400

ggtaactcta ccttcagtcg ggaacctaaa taatatgcgt gccacctact tggaaacctt     5460

atccgtaagc acaaccaggg gatttgcctc ggcacttgtc ccaaaagtgg tgacacaggt     5520

cggttctgtg atagaagaac ttgacacctc atactgtata gaaactgact tagatttata     5580

ttgtacaaga atagtaacgt tccctatgtc ccctggtatt tactcctgct tgagcggcaa     5640

tacatcggcc tgtatgtact caaagaccga aggcgcactt actacaccat atatgactat     5700

caaaggctca gtcatcgcta actgcaagat gacaacatgt agatgtgtaa accccccggg     5760

tatcatatcg caaaactatg gagaagccgt gtctctaata gataaacaat catgcaatgt     5820

tttatcctta ggcgggataa ctttaaggct cagtggggaa ttcgatgtaa cttatcagaa     5880

gaatatctca atacaagatt ctcaagtaat aataacaggc aatcttgata tctcaactga     5940

gcttgggaat gtcaacaact cgatcagtaa tgctttgaat aagttagagg aaagcaacag     6000

aaaactagac aaagtcaatg tcaaactgac cagcacatct gctctcatta cctatatcgt     6060

tttgactatc atatctcttg tttttggtat acttagcctg attctagcat gctacctaat     6120

gtacaagcaa aaggcgcaac aaaagacctt attatggctt gggaataata ccctagatca     6180

gatgagagcc actacaaaaa tgtgaacaca gatgaggaac gaaggtttcc ctaatagtaa     6240

tttgtgtgaa agttctggta gtctgtcagt tcggagagtt aagaaaaaac taccggttgt     6300

agatgaccaa aggacgatat acgggtagaa cggtaagaga ggccgcccct caattgcgag     6360

ccagacttca caacctccgt tctaccgctt caccgacaac agtcctcaat catggaccgc     6420

gccgttagcc aagttgcgtt agagaatgat gaaagagagg caaaaaatac atggcgcttg     6480

atattccgga ttgcaatctt attcttaaca gtagtgacct tggctatatc tgtagcctcc     6540

cttttatata gcatgggggc tagcacacct agcgatcttg taggcatacc gactaggatt     6600

tccagggcag aagaaaagat tacatctaca cttggttcca atcaagatgt agtagatagg     6660

atatataagc aagtggccct tgagtctcca ttggcattgt taaatactga gaccacaatt     6720

atgaacgcaa taacatctct ctcttatcag attaatggag ctgcaaacaa cagcgggtgg     6780

ggggcaccta ttcatgaccc agattatata ggggggatag gcaaagaact cattgtagat     6840

gatgctagtg atgtcacatc attctatccc tctgcatttc aagaacatct gaattttatc     6900

ccggcgccta ctacaggatc aggttgcact cgaataccct catttgacat gagtgctacc     6960

cattactgct acacccataa tgtaatattg tctggatgca gagatcactc acactcacat     7020

cagtatttag cacttggtgt gctccggaca tctgcaacag ggagggtatt cttttctact     7080

ctgcgttcca tcaacctgga cgacacccaa aatcggaagt cttgcagtgt gagtgcaact     7140

cccctgggtt gtgatatgct gtgctcgaaa gccacggaga cagaggaaga agattataac     7200

tcagctgtcc ctacgcggat ggtacatggg aggttagggt tcgacggcca atatcacgaa     7260

aaggacctag atgtcacaac attattcggg gactgggtgg ccaactaccc aggagtaggg     7320

ggtggatctt ttattgacag ccgcgtatgg ttctcagtct acggagggtt aaaacccaat     7380

acacccagtg acactgtaca ggaagggaaa tatgtgatat acaagcgata caatgacaca     7440

tgcccagatg agcaagacta ccagattcga atggccaagt cttcgtataa gcctggacgg     7500

tttggtggga aacgcataca gcaggctatc ttatctatca aagtgtcaac atccttaggc     7560

gaagacccgg tactgactgt accgcccaac acagtcacac tcatgggggc cgaaggcaga     7620

attctcacag tagggacatc ccatttcttg tatcagcgag ggtcatcata cttctctccc     7680

gcgttattat atcctatgac agtcagcgac aaaacagcca ctcttcatag tccttataca     7740

ttcaatgcct tcactcggcc aggtagtatc ccttgccagg cttcagcaag atgccccaac     7800

tcgtgtgtta ctggagtcta tacagatcca tatcccctaa tcttctatag aaaccacacc     7860

ttgcgagggg tattcgggac aatgcttgat ggtgaacaag caagacttaa ccctgcgtct     7920

gcagtattcg atagcacatc ccgcagtcgc ataactcgag tgagttcaag cagcatcaaa     7980

gcagcataca caacatcaac ttgttttaaa gtggtcaaga ccaataagac ctattgtctc     8040

agcattgctg aaatatctaa tactctcttc ggagaattca gaatcgtccc gttactagtt     8100

gagatcctca aagatgacgg ggttagagaa gccaggtctg gctagttgag tcaactatga     8160

aagagttgga aagatggcat tgtatcacct atcttctgcg acatcaagaa tcaaaccgaa     8220

tgccggcgcg tgctcgaatt ccatgtcgcc agttgaccac aatcagccag tgctcatgcg     8280

atcagattaa gccttgtcaa tagtctcttg attaagaaaa aatgtaagtg gcaatgagat     8340

acaaggcaaa acagctcacg gtaaataata cgggtaggac atggcgagct ccggtcctga     8400

aagggcagag catcagatta tcctaccaga gtcacacctg tcttcaccat tggtcaagca     8460

caaactactc tattattgga aattaactgg gctaccgctt cctgatgaat gtgacttcga     8520

ccacctcatt ctcagccgac aatggaaaaa aatacttgaa tcggcctctc ctgatactga     8580

gagaatgata aaactcggaa gggcagtaca ccaaactctt aaccacaatt ccagaataac     8640

cggagtactc caccccaggt gtttagaaga actggctaat attgaggtcc ctgattcaac     8700

caacaaattt cggaagattg agaagaagat ccaaattcac aacacgagat atggagaact     8760

gttcacaagg ctgtgtacgc atatagagaa gaaactgctg gggtcatctt ggtctaacaa     8820

tgtcccccgg tcagaggagt tcagcagcat tcgtacggat ccggcattct ggtttcactc     8880

aaaatggtcc acagccaagt ttgcatggct ccatataaaa cagatccaga ggcatctgat     8940

tgtggcagct aggacaaggt ctgcggccaa caaattggtg atgctaaccc ataaggtagg     9000

ccaagtcttt gtcactcctg aacttgttgt tgtgacgcat acgaatgaga acaagttcac     9060

atgtcttacc caggaacttg tattgatgta tgcagatatg atggagggca gagatatggt     9120

caacataata tcaaccacgg cggtgcatct cagaagctta tcagagaaaa ttgatgacat     9180

tttgcggtta atagacgctc tggcaaaaga cttgggtaat caagtctacg atgttgtatc     9240

actaatggag ggatttgcat acggagctgt ccagctactc gagccgtcag gtacatttgc     9300

gggagatttc ttcgcattca acctgcagga gcttaaagac attctaattg gcctcctccc     9360

caatgatata gcagaatccg tgactcatgc aatcgctact gtattctctg gtttagaaca     9420

gaatcaagca gctgagatgt tgtgcctgtt gcgtctgtgg ggtcacccac tgcttgagtc     9480

ccgtattgca gcaaaggcag tcaggagcca aatgtgcgca ccgaaaatgg tagactttga     9540

tatgatcctt caggtactgt ctttcttcaa gggaacaatc atcaacggat acagaaagaa     9600

gaatgcaggt gtgtggccgc gagtcaaagt ggatacaata tatgggaagg tcattgggca     9660

actacatgca gattcagcag agatttcaca cgatatcatg ttgagagagt ataagagttt     9720

atctgcactt gaatttgagc catgtataga atacgaccct gtcactaacc tgagcatgtt     9780

cctaaaagac aaggcaatcg cacaccccaa cgataattgg cttgcctcgt ttaggcggaa     9840

ccttctctcc gaagaccaga agaaacatgt aaaggaagcg acttcgacta accgcctctt     9900

gatagagttt ttagagtcaa atgattttga tccatataaa gagatggaat atctgacgac     9960

ccttgagtac cttagagatg acaatgtggc agtatcatac tcgctcaaag agaaggaagt    10020

gaaagttaat ggacggatct tcgctaagct gacaaagaag ttaaggaact gtcaggtgat    10080

ggcggaaggg atcctagccg atcagattgc acctttcttt cagggaaatg gagtcattca    10140

ggatagcata tccttgacca agagtatgct agcgatgagt caactgtctt ttaacagcaa    10200

taagaaacgt atcactgact gtaaagaaag agtatgttca aaccgcaatc atgatccgaa    10260

aagcaagaac cgtcggagag ttgcaacctt cataacaact gacctgcaaa agtactgtct    10320

taattggaga tatcagacga tcaaattgtt cgctcatgcc atcaatcagt tgatgggcct    10380

acctcatttc ttcgagtgga ttcacctaag actgatggac actacgatgt tcgtaggaga    10440

ccctttcaat cctccaagtg accctactga ctgtgacctc tcaagagtcc ctaatgatga    10500

catatatatt gtcagtgcca gagggggtat cgaaggatta tgccagaagc tatggacaat    10560

gatctcaatt gctgcaatcc aacttgctgc agctagatcg cattgtcgtg ttgcctgtat    10620

ggtacagggt gataatcaag taatagcagt aacgagagag gtaagatcag atgactctcc    10680

ggagatggtg ttgacacagt tgcatcaagc cagtgataat ttcttcaagg aattaatcca    10740

tgtcaatcat ttgattggcc ataatttgaa ggatcgtgaa accatcaggt cagacacatt    10800

cttcatatac agcaaacgaa tcttcaaaga tggagcaatc ctcagtcaag tcctcaaaaa    10860

ttcatctaaa ttagtgctag tgtcaggtga tctcagtgaa aacaccgtaa tgtcctgtgc    10920

caacattgcc tctactgtag cacggctatg cgagaacggg cttcccaaag acttctgtta    10980

ctatttaaac tatataatga gttgtgtgca gacatacttt gactctgagt tctccatcac    11040

caacaattcg caccccgatc ttaatcagtc gtggattgag gacatctctt ttgtgcactc    11100

atatgttctg actcctgccc aattaggggg actgagtaac cttcaatact caaggctcta    11160

cactagaaat atcggtgacc cggggactac tgcttttgca gagatcaagc gactagaagc    11220

agtgggacta ctgagtccta acattaggac taatatctta actaggccgc ctgggaatgg    11280

agattgggcc agtctgtgca acgacccata ctctttcaat tttgagactg ttgcaagccc    11340

aaacattgtt cttaagaaac atacgcaaag agtcctattt gaaacttgtt caaatccctt    11400

attgtctgga gtgcacacag aggataatga ggcagaagag aaggcattgg ctgaattctt    11460

gcttaatcaa gaggtgattc atccccgcgt tgcgcatgcc atcatggagg caagctctgt    11520

aggtaggaga aagcaaattc aagggcttgt tgacacaaca aacactgtaa ttaagattgc    11580

gcttactagg aggccattag gcatcaagag gctgatgcgg atagtcaatt attctagcat    11640

gcatgcaatg ctgtttagag acgatgtttt ttcctctagt agatccaacc accccttagt    11700

ctcttctaat atgtgttctc tgacactggc agactatgca cggaatagaa gctggtcacc    11760

tttgacggga ggcaggaaaa tactgggtgt atctaatcct gatacgatag aactcgtaga    11820

gggtgagatt cttagtgtaa gcggagggtg tacaagatgt gacagcggag atgaacaatt    11880

tacttggttc catcttccaa gcaatataga attgaccgat gacaccagca agaatcctcc    11940

gatgagggta ccatatctcg ggtcaaagac acaggagagg agagctgcct cacttgcgaa    12000

aatagctcat atgtcgccac atgtgaaggc tgccctaagg gcatcatccg tgttgatctg    12060

ggcttatggg gataatgaag taaattggac tgctgctctt acgattgcaa aatctcggtg    12120

taatgtaaac ttagagtatc ttcggttact gtccccttta cccacggctg ggaatcttca    12180

acatagacta gatgatggta taactcagat gacattcacc cctgcatctc tctacagggt    12240

gtcaccttac attcacatat ccaatgattc tcaaaggctg ttcactgaag aaggagtcaa    12300

agaggggaat gtggtttacc aacagatcat gctcttgggt ttatctctaa tcgaatcgat    12360

ctttccaatg acaacaacca gaacatatga tgagatcaca ctgcacctac atagtaaatt    12420

tagttgctgt atcagggaag cacctgttgc ggttcctttc gagctacttg gggtggcacc    12480

ggaactgagg acagtgacct caaataagtt tatgtatgat cctagccctg tatcggaggg    12540

agactttgcg agacttgact tagctatctt caagagttat gagcttaatc tggagtcata    12600

tcccacgata gagctaatga acattctttc aatatccagc gggaagttga ttggccagtc    12660

tgtggtttct tatgatgaag atacctccat aaagaatgat gccataatag tgtatgacaa    12720

tacccgaaat tggatcagtg aagctcagaa ttcagatgtg gtccgcctat ttgaatatgc    12780

agcacttgaa gtgctcctcg actgttctta ccaactctat tacctgagag taagagacct    12840

agacaatatt gtcttatata tgggtgattt atacaagaat atgccaggaa ttctactttc    12900

caacattgca gctacaatat ctcatcctgt cattcattca aggttacatg cagtgggcct    12960

ggtcaaccat gacggatcac accaacttgc agatacggat tttatcgaaa tgtctgcaaa    13020

actgttagta tcttgcaccc gacgtgtgat ctccggctta tattcaggaa ataagtatga    13080

tctgctgttc ccatctgtct tagatgataa cctgaatgag aagatgcttc agctgatatc    13140

ccggttatgc tgtctgtaca cggtactctt tgctacaaca agagaaatcc cgaaaataag    13200

aggcttaact gcagaagaga aatgttcaat actcactgag tatttactgt cggatgctgt    13260

gaaaccatta cttagccccg atcaagtgag ctctatcatg tctcctaaca taattacatt    13320

cccagctaat ctgtactaca tgtctcggaa gagcctcaat ttgatcaggg aaagggagga    13380

cagggatact atcctggcgt tgttgttccc ccaagagcca ttattagagt tcccttctgt    13440

gcaagatatt ggtgctcgag tgaaagatcc attcacccga caacctgcgg catttttgca    13500

agagttagat ttgagtgctc cagcaaggta tgacgcattc acacttagtc agattcatcc    13560

tgaactcaca tctccaaatc cggaggaaga ctacttagta cgatacttgt tcagagggat    13620

agggactgca tcttcctctt ggtataaggc atcccatctc ctttctgtac ccgaggtaag    13680

atgtgcaaga cacgggaact ccttatactt ggctgaagga agcggagcca tcatgagtct    13740

tcttgaactg catgtaccac atgaaactat ctattacaat acgctctttt caaatgagat    13800

gaaccccccg caacgacatt tcgggccgac cccaactcag tttttgaatt cggttgttta    13860

taggaatcta caggcggagg taacatgcaa ggatggattt gtccaagagt tccgtccatt    13920

atggagagaa aatacagagg aaagtgacct gacctcagat aaagcagtgg ggtatattac    13980

atctgcagta ccctacagat ctgtatcatt gctgcattgt gacattgaaa ttcctccagg    14040

gtccaatcaa agcttactag atcaactagc tatcaattta tctctgattg ccatgcattc    14100

tgtaagggag ggcggggtag taatcatcaa agtgttgtat gcaatgggat actactttca    14160

tctactcatg aacttgtttg ctccgtgttc cacaaaagga tatattctct ctaatggtta    14220

tgcatgtcga ggggatatgg agtgttacct ggtatttgtc atgggttacc tgggcgggcc    14280

tacatttgta catgaggtgg tgaggatggc aaaaactctg gtgcagcggc acggtacgct    14340

tttgtctaaa tcagatgaga tcacactgac caggttattc acctcacagc ggcagcgtgt    14400

gacagacatc ctatccagtc ctttaccaag attaataaag tacttgagga agaatattga    14460

cactgcgctg attgaagccg ggggacagcc cgtccgtcca ttctgtgcgg agagtctggt    14520

gagcacgcta gcgaacataa ctcagataac ccagatcatc gctagtcaca ttgacacagt    14580

catccggtct gtgatatata tggaagctga gggtgatctc gctgacacag tatttctatt    14640

taccccttac aatctctcta ctgacgggaa aaagaggaca tcacttaaac agtgcacgag    14700

acagatccta gaggttacaa tactaggtct tagagtcgaa aatctcaata aaataggcga    14760

tataatcagc ctagtgctta aaggcatgat ctccatggag gaccttatcc cactaaggac    14820

atacttgaag catagtacct gccctaaata tttgaaggct gtcctaggta ttaccaaact    14880

caaagaaatg tttacagaca cttctgtact gtacttgact cgtgctcaac aaaaattcta    14940

catgaaaact ataggcaatg cagtcaaagg atattacagt aactgtgact cctaacgaaa    15000

atcacatatt aataggctcc ttttttggcc aattgtattc ttgttgattt aattatatta    15060

tgttagaaaa aagttgaact ctgactcctt aggactcgaa ttcgaactca aataaatgtc    15120

tttaaaaaag gttgcgcaca attattcttg agtgtagtct cgtcattcac caaatctttg    15180

tttggt                                                               15186


<210> 21
<211> 1782
<212> DNA
<213> Newcastle disease virus


<220> 
<223> NDV F (unmodified) protein (nucleotide sequence)

<400> 21
acgggtagaa gactctggat cccggttggc gccctccagg tgcaggatgg gctccagacc      60

ttttaccaag aacccagcac ctatgatgct gactatccgg gtcgcgctgg tattgagttg     120

catctgtccg gcaaactcca ttgatggcag gccttttgca gctgcaggaa ttgtggttac     180

aggagacaaa gcagtcaaca tatacacctc atcccagaca ggatcaatca tagttaagct     240

cctcccgaat ctgcccaagg ataaggaggc atgtgcgaaa gcccccttgg atgcatacaa     300

caggacattg accactttgc tcacccccct tggtgactct atccgtagga tacaagagtc     360

tgtgactaca tctggagggg ggagacaggg gcgccttata ggcgccatta ttggcggtgt     420

ggctcttggg gttgcaactg ccgcacaaat aacagcggcc gcagctctga tacaagccaa     480

acaaaatgct gccaacatcc tccgacttaa agagagcatt gccgcaacca atgaggctgt     540

gcatgaggtc actgacggat tatcccaact agcagtggca gttgggaaga tgcagcagtt     600

tgttaatgac caatttaata aaacagctca ggaattagac tgcataaaaa ttgcacagca     660

agttggtgta gagctcaacc tgtacctaac cgaattgact acagtattcg gaccacaaat     720

cacttcacct gccttaaaca agctgactat tcaggcactt tacaatctag ctggtgggaa     780

tatggattac ttattgacta agttaggtat agggaacaat caactcagct cattaatcgg     840

tagcggctta atcaccggta accctattct atacgactca cagactcaac tcttgggtat     900

acaggtaact ctaccttcag tcgggaacct aaataatatg cgtgccacct acttggaaac     960

cttatccgta agcacaacca ggggatttgc ctcggcactt gtcccaaaag tggtgacaca    1020

ggtcggttct gtgatagaag aacttgacac ctcatactgt atagaaactg acttagattt    1080

atattgtaca agaatagtaa cgttccctat gtcccctggt atttactcct gcttgagcgg    1140

caatacatcg gcctgtatgt actcaaagac cgaaggcgca cttactacac catatatgac    1200

tatcaaaggc tcagtcatcg ctaactgcaa gatgacaaca tgtagatgtg taaacccccc    1260

gggtatcata tcgcaaaact atggagaagc cgtgtctcta atagataaac aatcatgcaa    1320

tgttttatcc ttaggcggga taactttaag gctcagtggg gaattcgatg taacttatca    1380

gaagaatatc tcaatacaag attctcaagt aataataaca ggcaatcttg atatctcaac    1440

tgagcttggg aatgtcaaca actcgatcag taatgctttg aataagttag aggaaagcaa    1500

cagaaaacta gacaaagtca atgtcaaact gaccagcaca tctgctctca ttacctatat    1560

cgttttgact atcatatctc ttgtttttgg tatacttagc ctgattctag catgctacct    1620

aatgtacaag caaaaggcgc aacaaaagac cttattatgg cttgggaata ataccctaga    1680

tcagatgaga gccactacaa aaatgtgaac acagatgagg aacgaaggtt tccctaatag    1740

taatttgtgt gaaagttctg gtagtctgtc agttcggaga gt                       1782


<210> 22
<211> 553
<212> PRT
<213> Newcastle disease virus


<220> 
<223> NDV F (unmodified) protein (amino acid sequence)

<400> 22
Met Gly Ser Arg Pro Phe Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      
Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          
Asp Gly Arg Pro Phe Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              
Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  
Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  
Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      
Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Gly 
            100                 105                 110         
Arg Gln Gly Arg Leu Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             
Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 
Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 
Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     
Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         
Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             
Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 
Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 
Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     
Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         
Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             
Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 
Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 
Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     
Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         
Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             
Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 
Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 
Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     
Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         
Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             
Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 
Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 
Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     
Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         
Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             
Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 
Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             

<210> 23
<211> 1662
<212> DNA
<213> Artificial Sequence


<220> 
<223> NDV F3aa-modified fusion protein with L289A (nucleotide sequence)

<400> 23
atgggctcca gaccttctac caagaaccca gcacctatga tgctgactat ccgggtcgcg      60

ctggtactga gttgcatctg cccggcaaac tccattgatg gcaggcctct tgcagctgca     120

ggaattgtgg ttacaggaga caaagcagtc aacatataca cctcatccca gacaggatca     180

atcatagtta agctcctccc gaatctgccc aaggataagg aggcatgtgc gaaagccccc     240

ttggatgcat acaacaggac attgaccact ttgctcaccc cccttggtga ctctatccgt     300

aggatacaag agtctgtgac tacatctgga gggcggagac agaggcgctt tataggcgcc     360

attattggcg gtgtggctct tggggttgca actgccgcac aaataacagc ggccgcagct     420

ctgatacaag ccaaacaaaa tgctgccaac atcctccgac ttaaagagag cattgccgca     480

accaatgagg ctgtgcatga ggtcactgac ggattatcgc aactagcagt ggcagttggg     540

aagatgcagc agtttgttaa tgaccaattt aataaaacag ctcaggaatt agactgcatc     600

aaaattgcac agcaagttgg tgtagagctc aacctgtacc taaccgaatt gactacagta     660

ttcggaccac aaatcacttc acctgcctta aacaagctga ctattcaggc actttacaat     720

ctagctggtg ggaatatgga ttacttattg actaagttag gtatagggaa caatcaactc     780

agctcattaa tcggtagcgg cttaatcacc ggtaacccta ttctatacga ctcacagact     840

caactcttgg gtatacaggt aactgcacct tcagtcggga acctaaataa tatgcgtgcc     900

acctacttgg aaaccttatc cgtaagcaca accaggggat ttgcctcggc acttgtccca     960

aaagtggtga cacaggtcgg ttctgtgata gaagaacttg acacctcata ctgtatagaa    1020

actgacttag atttatattg tacaagaata gtaacgttcc ctatgtcccc tggtatttac    1080

tcctgcttga gcggcaatac atcggcctgt atgtactcaa agaccgaagg cgcacttact    1140

acaccatata tgactatcaa aggctcagtc atcgctaact gcaagatgac aacatgtaga    1200

tgtgtaaacc ccccgggtat catatcgcaa aactatggag aagccgtgtc tctaatagat    1260

aaacaatcat gcaatgtttt atccttaggc gggataactt taaggctcag tggggaattc    1320

gatgtaactt atcagaagaa tatctcaata caagattctc aagtaataat aacaggcaat    1380

cttgatatct caactgagct tgggaatgtc aacaactcga tcagtaatgc tttgaataag    1440

ttagaggaaa gcaacagaaa actagacaaa gtcaatgtca aactgaccag cacatctgct    1500

ctcattacct atatcgtttt gactatcata tctcttgttt ttggtatact tagcctgatt    1560

ctagcatgct acctaatgta caagcaaaag gcgcaacaaa agaccttatt atggcttggg    1620

aataataccc tagatcagat gagagccact acaaaaatgt ga                       1662


<210> 24
<211> 1662
<212> DNA
<213> Artificial Sequence


<220> 
<223> NDV F3aa-modifed fusion protein (nucleotide sequence)

<400> 24
atgggctcca gaccttctac caagaaccca gcacctatga tgctgactat ccgggtcgcg      60

ctggtactga gttgcatctg cccggcaaac tccattgatg gcaggcctct tgcagctgca     120

ggaattgtgg ttacaggaga caaagcagtc aacatataca cctcatccca gacaggatca     180

atcatagtta agctcctccc gaatctgccc aaggataagg aggcatgtgc gaaagccccc     240

ttggatgcat acaacaggac attgaccact ttgctcaccc cccttggtga ctctatccgt     300

aggatacaag agtctgtgac tacatctgga gggcggagac agaggcgctt tataggcgcc     360

attattggcg gtgtggctct tggggttgca actgccgcac aaataacagc ggccgcagct     420

ctgatacaag ccaaacaaaa tgctgccaac atcctccgac ttaaagagag cattgccgca     480

accaatgagg ctgtgcatga ggtcactgac ggattatcgc aactagcagt ggcagttggg     540

aagatgcagc agtttgttaa tgaccaattt aataaaacag ctcaggaatt agactgcatc     600

aaaattgcac agcaagttgg tgtagagctc aacctgtacc taaccgaatt gactacagta     660

ttcggaccac aaatcacttc acctgcctta aacaagctga ctattcaggc actttacaat     720

ctagctggtg ggaatatgga ttacttattg actaagttag gtatagggaa caatcaactc     780

agctcattaa tcggtagcgg cttaatcacc ggtaacccta ttctatacga ctcacagact     840

caactcttgg gtatacaggt aactctacct tcagtcggga acctaaataa tatgcgtgcc     900

acctacttgg aaaccttatc cgtaagcaca accaggggat ttgcctcggc acttgtccca     960

aaagtggtga cacaggtcgg ttctgtgata gaagaacttg acacctcata ctgtatagaa    1020

actgacttag atttatattg tacaagaata gtaacgttcc ctatgtcccc tggtatttac    1080

tcctgcttga gcggcaatac atcggcctgt atgtactcaa agaccgaagg cgcacttact    1140

acaccatata tgactatcaa aggctcagtc atcgctaact gcaagatgac aacatgtaga    1200

tgtgtaaacc ccccgggtat catatcgcaa aactatggag aagccgtgtc tctaatagat    1260

aaacaatcat gcaatgtttt atccttaggc gggataactt taaggctcag tggggaattc    1320

gatgtaactt atcagaagaa tatctcaata caagattctc aagtaataat aacaggcaat    1380

cttgatatct caactgagct tgggaatgtc aacaactcga tcagtaatgc tttgaataag    1440

ttagaggaaa gcaacagaaa actagacaaa gtcaatgtca aactgaccag cacatctgct    1500

ctcattacct atatcgtttt gactatcata tctcttgttt ttggtatact tagcctgatt    1560

ctagcatgct acctaatgta caagcaaaag gcgcaacaaa agaccttatt atggcttggg    1620

aataataccc tagatcagat gagagccact acaaaaatgt ga                       1662


<210> 25
<211> 553
<212> PRT
<213> Artificial Sequence


<220> 
<223> NDV F3aa-modified fusion protein (amino acid sequence)

<400> 25
Met Gly Ser Arg Pro Phe Thr Lys Asn Pro Ala Pro Met Met Leu Thr 
1               5                   10                  15      
Ile Arg Val Ala Leu Val Leu Ser Cys Ile Cys Pro Ala Asn Ser Ile 
            20                  25                  30          
Asp Gly Arg Pro Phe Ala Ala Ala Gly Ile Val Val Thr Gly Asp Lys 
        35                  40                  45              
Ala Val Asn Ile Tyr Thr Ser Ser Gln Thr Gly Ser Ile Ile Val Lys 
    50                  55                  60                  
Leu Leu Pro Asn Leu Pro Lys Asp Lys Glu Ala Cys Ala Lys Ala Pro 
65                  70                  75                  80  
Leu Asp Ala Tyr Asn Arg Thr Leu Thr Thr Leu Leu Thr Pro Leu Gly 
                85                  90                  95      
Asp Ser Ile Arg Arg Ile Gln Glu Ser Val Thr Thr Ser Gly Gly Arg 
            100                 105                 110         
Arg Gln Arg Arg Phe Ile Gly Ala Ile Ile Gly Gly Val Ala Leu Gly 
        115                 120                 125             
Val Ala Thr Ala Ala Gln Ile Thr Ala Ala Ala Ala Leu Ile Gln Ala 
    130                 135                 140                 
Lys Gln Asn Ala Ala Asn Ile Leu Arg Leu Lys Glu Ser Ile Ala Ala 
145                 150                 155                 160 
Thr Asn Glu Ala Val His Glu Val Thr Asp Gly Leu Ser Gln Leu Ala 
                165                 170                 175     
Val Ala Val Gly Lys Met Gln Gln Phe Val Asn Asp Gln Phe Asn Lys 
            180                 185                 190         
Thr Ala Gln Glu Leu Asp Cys Ile Lys Ile Ala Gln Gln Val Gly Val 
        195                 200                 205             
Glu Leu Asn Leu Tyr Leu Thr Glu Leu Thr Thr Val Phe Gly Pro Gln 
    210                 215                 220                 
Ile Thr Ser Pro Ala Leu Asn Lys Leu Thr Ile Gln Ala Leu Tyr Asn 
225                 230                 235                 240 
Leu Ala Gly Gly Asn Met Asp Tyr Leu Leu Thr Lys Leu Gly Ile Gly 
                245                 250                 255     
Asn Asn Gln Leu Ser Ser Leu Ile Gly Ser Gly Leu Ile Thr Gly Asn 
            260                 265                 270         
Pro Ile Leu Tyr Asp Ser Gln Thr Gln Leu Leu Gly Ile Gln Val Thr 
        275                 280                 285             
Leu Pro Ser Val Gly Asn Leu Asn Asn Met Arg Ala Thr Tyr Leu Glu 
    290                 295                 300                 
Thr Leu Ser Val Ser Thr Thr Arg Gly Phe Ala Ser Ala Leu Val Pro 
305                 310                 315                 320 
Lys Val Val Thr Gln Val Gly Ser Val Ile Glu Glu Leu Asp Thr Ser 
                325                 330                 335     
Tyr Cys Ile Glu Thr Asp Leu Asp Leu Tyr Cys Thr Arg Ile Val Thr 
            340                 345                 350         
Phe Pro Met Ser Pro Gly Ile Tyr Ser Cys Leu Ser Gly Asn Thr Ser 
        355                 360                 365             
Ala Cys Met Tyr Ser Lys Thr Glu Gly Ala Leu Thr Thr Pro Tyr Met 
    370                 375                 380                 
Thr Ile Lys Gly Ser Val Ile Ala Asn Cys Lys Met Thr Thr Cys Arg 
385                 390                 395                 400 
Cys Val Asn Pro Pro Gly Ile Ile Ser Gln Asn Tyr Gly Glu Ala Val 
                405                 410                 415     
Ser Leu Ile Asp Lys Gln Ser Cys Asn Val Leu Ser Leu Gly Gly Ile 
            420                 425                 430         
Thr Leu Arg Leu Ser Gly Glu Phe Asp Val Thr Tyr Gln Lys Asn Ile 
        435                 440                 445             
Ser Ile Gln Asp Ser Gln Val Ile Ile Thr Gly Asn Leu Asp Ile Ser 
    450                 455                 460                 
Thr Glu Leu Gly Asn Val Asn Asn Ser Ile Ser Asn Ala Leu Asn Lys 
465                 470                 475                 480 
Leu Glu Glu Ser Asn Arg Lys Leu Asp Lys Val Asn Val Lys Leu Thr 
                485                 490                 495     
Ser Thr Ser Ala Leu Ile Thr Tyr Ile Val Leu Thr Ile Ile Ser Leu 
            500                 505                 510         
Val Phe Gly Ile Leu Ser Leu Ile Leu Ala Cys Tyr Leu Met Tyr Lys 
        515                 520                 525             
Gln Lys Ala Gln Gln Lys Thr Leu Leu Trp Leu Gly Asn Asn Thr Leu 
    530                 535                 540                 
Asp Gln Met Arg Ala Thr Thr Lys Met 
545                 550             

<210> 26
<211> 510
<212> DNA
<213> Homo sapiens


<220> 
<223> Human soluble PD1 (sPD1)

<400> 26
atgcagatcc cacaggcgcc ctggccagtc gtctgggcgg tgctacaact gggctggcgg      60

ccaggatggt tcttagactc cccagacagg ccctggaacc cccccacctt ctccccagcc     120

ctgctcgtgg tgaccgaagg ggacaacgcc accttcacct gcagcttctc caacacatcg     180

gagagcttcg tgctaaactg gtaccgcatg agccccagca accagacgga caagctggcc     240

gccttccccg aggaccgcag ccagcccggc caggactgcc gcttccgtgt cacacaactg     300

cccaacgggc gtgacttcca catgagcgtg gtcagggccc ggcgcaatga cagcggcacc     360

tacctctgtg gggccatctc cctggccccc aaggcgcaga tcaaagagag cctgcgggca     420

gagctcaggg tgacagagag aagggcagaa gtgcccacag cccaccccag cccctcaccc     480

aggccagccg gccagttcca aaccctggtg                                      510


