                         SEQUENCE LISTING

<110>  Hummingbird Bioscience Holdings Limited (All states)
       Clegg, Richard I (LS Only)
 
<120>  BCMA/TACI Antigen-Binding Molecules

<130>  008127268

<150>  GB 2017319.1
<151>  2020-11-02

<150>  GB 2104935.8
<151>  2021-04-07

<160>  558   

<170>  PatentIn version 3.5

<210>  1
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  2
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Arg Ser Gly Leu Leu 
        35                  40                  45              


Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu Ile 
    50                  55                  60                  


Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
65                  70                  75                  80  


Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro 
                85                  90                  95      


Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
            100                 105                 110         


Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu Ile 
        115                 120                 125             


Glu Lys Ser Ile Ser Ala Arg 
    130                 135 


<210>  3
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala 
    50                  


<210>  4
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  4

Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Ala Cys Ile 
1               5                   10                  15      


Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln 
            20                  25                  30          


Arg Tyr Cys 
        35  


<210>  5
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  5

Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile Ile Ser Leu Ala Val 
1               5                   10                  15      


Phe Val Leu Met Phe Leu Leu 
            20              


<210>  6
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Lys Ile Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly 
1               5                   10                  15      


Ser Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr 
            20                  25                  30          


Gly Asp Glu Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu 
        35                  40                  45              


Cys Thr Cys Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp 
    50                  55                  60                  


His Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val 
65                  70                  75                  80  


Thr Thr Lys Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser 
                85                  90                  95      


Ala Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
            100                 105         


<210>  7
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu Asp Cys Ile Lys Ser 
1               5                   10                  15      


Lys Pro Lys Val Asp Ser Asp His Cys 
            20                  25  


<210>  8
<211>  183
<212>  PRT
<213>  Cynomorium macaque

<400>  8

Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Met Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile 
    50                  55                  60                  


Ile Ser Leu Ala Val Phe Val Leu Thr Phe Leu Leu Arg Lys Met Ser 
65                  70                  75                  80  


Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu Leu 
                85                  90                  95      


Gly Met Ala Asn Ile Asp Leu Glu Lys Gly Arg Thr Gly Asp Glu Ile 
            100                 105                 110         


Val Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
        115                 120                 125             


Asp Cys Ile Lys Asn Lys Pro Lys Val Asp Ser Asp His Cys Phe Pro 
    130                 135                 140                 


Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
145                 150                 155                 160 


Asn Asp Tyr Cys Asn Ser Leu Ser Ala Ala Leu Ser Val Thr Glu Ile 
                165                 170                 175     


Glu Lys Ser Ile Ser Ala Arg 
            180             


<210>  9
<211>  53
<212>  PRT
<213>  Cynomorium macaque

<400>  9

Met Leu Gln Met Ala Arg Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Asp Cys Lys Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Met Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Met Asn Ala 
    50              


<210>  10
<211>  34
<212>  PRT
<213>  Cynomorium macaque

<400>  10

Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu His Asp Cys Lys 
1               5                   10                  15      


Pro Cys Gln Leu Arg Cys Ser Ser Thr Pro Pro Leu Thr Cys Gln Arg 
            20                  25                  30          


Tyr Cys 
        


<210>  11
<211>  23
<212>  PRT
<213>  Cynomorium macaque

<400>  11

Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu Ile Ile Ser Leu Ala Val 
1               5                   10                  15      


Phe Val Leu Thr Phe Leu Leu 
            20              


<210>  12
<211>  107
<212>  PRT
<213>  Cynomorium macaque

<400>  12

Arg Lys Met Ser Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly 
1               5                   10                  15      


Ser Gly Leu Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Gly Arg Thr 
            20                  25                  30          


Gly Asp Glu Ile Val Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu 
        35                  40                  45              


Cys Thr Cys Glu Asp Cys Ile Lys Asn Lys Pro Lys Val Asp Ser Asp 
    50                  55                  60                  


His Cys Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val 
65                  70                  75                  80  


Thr Thr Lys Thr Asn Asp Tyr Cys Asn Ser Leu Ser Ala Ala Leu Ser 
                85                  90                  95      


Val Thr Glu Ile Glu Lys Ser Ile Ser Ala Arg 
            100                 105         


<210>  13
<211>  25
<212>  PRT
<213>  Cynomorium macaque

<400>  13

Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu Asp Cys Ile Lys Asn 
1               5                   10                  15      


Lys Pro Lys Val Asp Ser Asp His Cys 
            20                  25  


<210>  14
<211>  185
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 
1               5                   10                  15      


Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 
            20                  25                  30          


Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 
        35                  40                  45              


Thr Val Leu Trp Ile Phe Leu Gly Leu Thr Leu Val Leu Ser Leu Ala 
    50                  55                  60                  


Leu Phe Thr Ile Ser Phe Leu Leu Arg Lys Met Asn Pro Glu Ala Leu 
65                  70                  75                  80  


Lys Asp Glu Pro Gln Ser Pro Gly Gln Leu Asp Gly Ser Ala Gln Leu 
                85                  90                  95      


Asp Lys Ala Asp Thr Glu Leu Thr Arg Ile Arg Ala Gly Asp Asp Arg 
            100                 105                 110         


Ile Phe Pro Arg Ser Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu 
        115                 120                 125             


Asp Cys Val Lys Ser Lys Pro Lys Gly Asp Ser Asp His Phe Phe Pro 
    130                 135                 140                 


Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr 
145                 150                 155                 160 


Gly Asp Tyr Gly Lys Ser Ser Val Pro Thr Ala Leu Gln Ser Val Met 
                165                 170                 175     


Gly Met Glu Lys Pro Thr His Thr Arg 
            180                 185 


<210>  15
<211>  180
<212>  PRT
<213>  Mus musculus

<400>  15

Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 
1               5                   10                  15      


Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 
            20                  25                  30          


Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 
        35                  40                  45              


Thr Val Leu Trp Ile Phe Leu Gly Leu Thr Leu Val Leu Ser Leu Ala 
    50                  55                  60                  


Leu Phe Thr Ile Ser Phe Leu Leu Arg Lys Met Asn Pro Glu Ala Leu 
65                  70                  75                  80  


Lys Asp Glu Pro Gln Ser Gly Ser Ala Gln Leu Asp Lys Ala Asp Thr 
                85                  90                  95      


Glu Leu Thr Arg Ile Arg Ala Gly Asp Asp Arg Ile Phe Pro Arg Ser 
            100                 105                 110         


Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu Asp Cys Val Lys Ser 
        115                 120                 125             


Lys Pro Lys Gly Asp Ser Asp His Phe Phe Pro Leu Pro Ala Met Glu 
    130                 135                 140                 


Glu Gly Ala Thr Ile Leu Val Thr Thr Lys Thr Gly Asp Tyr Gly Lys 
145                 150                 155                 160 


Ser Ser Val Pro Thr Ala Leu Gln Ser Val Met Gly Met Glu Lys Pro 
                165                 170                 175     


Thr His Thr Arg 
            180 


<210>  16
<211>  49
<212>  PRT
<213>  Mus musculus

<400>  16

Met Ala Gln Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His 
1               5                   10                  15      


Ala Cys Lys Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys 
            20                  25                  30          


Gln Pro Tyr Cys Asp Pro Ser Val Thr Ser Ser Val Lys Gly Thr Tyr 
        35                  40                  45              


Thr 
    


<210>  17
<211>  33
<212>  PRT
<213>  Cynomorium macaque

<400>  17

Gln Cys Phe His Ser Glu Tyr Phe Asp Ser Leu Leu His Ala Cys Lys 
1               5                   10                  15      


Pro Cys His Leu Arg Cys Ser Asn Pro Pro Ala Thr Cys Gln Pro Tyr 
            20                  25                  30          


Cys 
    


<210>  18
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  18

Val Leu Trp Ile Phe Leu Gly Leu Thr Leu Val Leu Ser Leu Ala Leu 
1               5                   10                  15      


Phe Thr Ile Ser Phe 
            20      


<210>  19
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  19

Leu Leu Arg Lys Met Asn Pro Glu Ala Leu Lys Asp Glu Pro Gln Ser 
1               5                   10                  15      


Pro Gly Gln Leu Asp Gly Ser Ala Gln Leu Asp Lys Ala Asp Thr Glu 
            20                  25                  30          


Leu Thr Arg Ile Arg Ala Gly Asp Asp Arg Ile Phe Pro Arg Ser Leu 
        35                  40                  45              


Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu Asp Cys Val Lys Ser Lys 
    50                  55                  60                  


Pro Lys Gly Asp Ser Asp His Phe Phe Pro Leu Pro Ala Met Glu Glu 
65                  70                  75                  80  


Gly Ala Thr Ile Leu Val Thr Thr Lys Thr Gly Asp Tyr Gly Lys Ser 
                85                  90                  95      


Ser Val Pro Thr Ala Leu Gln Ser Val Met Gly Met Glu Lys Pro Thr 
            100                 105                 110         


His Thr Arg 
        115 


<210>  20
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  20

Leu Leu Arg Lys Met Asn Pro Glu Ala Leu Lys Asp Glu Pro Gln Ser 
1               5                   10                  15      


Gly Ser Ala Gln Leu Asp Lys Ala Asp Thr Glu Leu Thr Arg Ile Arg 
            20                  25                  30          


Ala Gly Asp Asp Arg Ile Phe Pro Arg Ser Leu Glu Tyr Thr Val Glu 
        35                  40                  45              


Glu Cys Thr Cys Glu Asp Cys Val Lys Ser Lys Pro Lys Gly Asp Ser 
    50                  55                  60                  


Asp His Phe Phe Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu 
65                  70                  75                  80  


Val Thr Thr Lys Thr Gly Asp Tyr Gly Lys Ser Ser Val Pro Thr Ala 
                85                  90                  95      


Leu Gln Ser Val Met Gly Met Glu Lys Pro Thr His Thr Arg 
            100                 105                 110 


<210>  21
<211>  25
<212>  PRT
<213>  Mus musculus

<400>  21

Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys Glu Asp Cys Val Lys Ser 
1               5                   10                  15      


Lys Pro Lys Gly Asp Ser Asp His Phe 
            20                  25  


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  23

Gly Tyr Thr Phe Thr Ser Tyr Val 
1               5               


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  24

Ile Leu Pro Phe Asn Asp Val Thr 
1               5               


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  25

Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  26

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  27

Met His Trp Val Lys Gln Lys Pro Gly Arg Gly Leu Glu Trp Ile Ala 
1               5                   10                  15      


Tyr 
    


<210>  28
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  28

Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  30
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  30

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  31

Gln Ser Leu Glu Asn Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  32
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  32

Arg Val Ser 
1           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  33

Leu Gln Val Ser His Val Pro Phe Thr 
1               5                   


<210>  34
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  34

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  35

Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  36
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  36

Asn Arg Phe Ser Gly Val Leu Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Val Tyr Phe Cys 
        35      


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  37

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  38
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  38

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Leu Pro Tyr Asn Asp Val Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Phe Asp Glu Gly Ile Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  39

Val Leu Pro Tyr Asn Asp Val Ile 
1               5               


<210>  40
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  40

Ala Arg Trp Gly Asp Phe Asp Glu Gly Ile Trp Phe Pro Tyr 
1               5                   10                  


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  41

Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  42
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  42

Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Asp Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  43

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  44
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  44

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Val Ser Cys Arg Ser Ser Gln Ser Ile Val His Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  45

Gln Ser Ile Val His Thr Asp Gly Asn Thr Tyr 
1               5                   10      


<210>  46
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  46

Lys Val Ser 
1           


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  47

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  48
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  48

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Val Ser Cys Arg Ser Ser 
            20                  25      


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  49

Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  50
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  50

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  51

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  52
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  52

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Val Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser 
        115             


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  53

Gly Tyr Thr Phe Thr Asn Tyr Val 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  54

Ile Leu Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  55

Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr 
1               5                   10      


<210>  56
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  56

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  57

Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  58
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  58

Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Phe Ser Val Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  59

Trp Gly Gln Gly Thr Ala Leu Thr Val Ser Ser 
1               5                   10      


<210>  60
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  60

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  61
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  61

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  62
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  62

Tyr Thr Ser 
1           


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  63

Gln Gln Gly Asn Thr Phe Pro Pro Thr 
1               5                   


<210>  64
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  64

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
            20                  25      


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  65

Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Met 
1               5                   10                  15      


Cys 
    


<210>  66
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  66

Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  67
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  67

Glu Val Met Leu Val Asp Ser Gly Gly Asn Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Val Gly Thr Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Arg His Lys Tyr Gly Tyr Asp Asp Pro Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120             


<210>  68
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  68

Gly Phe Thr Phe Ser Asn Tyr Val 
1               5               


<210>  69
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  69

Ile Ser Thr Val Gly Thr Asn Thr 
1               5               


<210>  70
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  70

Ser Arg His Lys Tyr Gly Tyr Asp Asp Pro Ser Tyr Ala Met Asp Tyr 
1               5                   10                  15      


<210>  71
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  71

Glu Val Met Leu Val Asp Ser Gly Gly Asn Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  72

Ile Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  15      


Thr 
    


<210>  73
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  73

Tyr Tyr Pro Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Glu Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  74

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  75
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  75

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Ala Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Val Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  76

Ser Gln His Ser Thr Tyr Thr 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  77

Leu Lys Lys Asp Gly Ser His 
1               5           


<210>  78
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  78

Gly Val Gly Asp Thr Val Lys Glu Gln Phe Val Tyr Val 
1               5                   10              


<210>  79
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  79

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser 
            20                  25  


<210>  80
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  80

Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
1               5                   10                  15      


Glu 
    


<210>  81
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  81

Ser Thr Gly Asp Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
1               5                   10                  15      


Ala Asp Arg Tyr Leu Ser Ile Ser Asn Ile Gln Ala Glu Asp Glu Ala 
            20                  25                  30          


Ile Tyr Ile Cys 
        35      


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  82

Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
1               5                   10  


<210>  83
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  83

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Ile Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Phe Ser Leu Thr Ser Glu Asp Ser Thr Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  84

Gly Tyr Ser Phe Thr Gly Tyr Ile 
1               5               


<210>  85
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  85

Ile Asn Pro Tyr Asn Gly Asp Ser 
1               5               


<210>  86
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  86

Ala Ala Gly Glu Glu Phe Ala Tyr 
1               5               


<210>  87
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  87

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  88
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  88

Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile Gly 
1               5                   10                  15      


Leu 
    


<210>  89
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  89

Ile Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Leu Phe Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Thr Val Tyr Tyr Cys 
        35              


<210>  90
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  90

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ile Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu His Pro Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser His Leu Glu His 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys 
            100                 105         


<210>  91
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  91

Gln Asp Ile Ser Ile Tyr 
1               5       


<210>  92
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  92

Phe Thr Ser 
1           


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  93

Gln Gln Gly Asn Thr Leu Pro Arg Thr 
1               5                   


<210>  94
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  94

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser 
            20                  25      


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  95

Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  96
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  96

Arg Leu His Pro Gly Val Pro Ser Arg Phe Ser Ala Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Tyr Ser Leu Thr Ile Ser His Leu Glu His Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  97

Phe Gly Gly Gly Thr Lys Val Glu Leu Lys 
1               5                   10  


<210>  98
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  98

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  99
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  99

Gly Tyr Thr Phe Thr Asp Tyr Ser 
1               5               


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  100

Ile Asn Thr Glu Thr Gly Glu Pro 
1               5               


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  101

Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  102
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  102

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  103
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  103

Ile Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  104
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  104

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Ser Ala Tyr Leu Gln Ile Asn Thr Leu Lys Asn Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Phe Cys 
        35              


<210>  105
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  105

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  106

Lys Ser Val Ser Thr Ser Gly Tyr Ser Phe 
1               5                   10  


<210>  107
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  107

Phe Ala Ser 
1           


<210>  108
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  108

Gln His Ser Arg Glu Leu Pro Arg Thr 
1               5                   


<210>  109
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  109

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            20                  25      


<210>  110
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  110

Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  111
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  111

Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  112
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  112

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Val Arg Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Ala Leu Asp Tyr Trp Gly His Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  113

Ala Ile Ser Tyr Tyr Tyr Ala Leu Asp Tyr 
1               5                   10  


<210>  114
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  114

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Met Ala Ser 
            20                  25  


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  115

Val Arg Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  116
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  116

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Phe Cys 
        35              


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  117

Trp Gly His Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  118
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  118

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Val Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  119

Lys Ser Val Ser Thr Ser Val Tyr Ser Phe 
1               5                   10  


<210>  120
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  120

Leu Ala Ser 
1           


<210>  121
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  121

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            20                  25      


<210>  122
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  122

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Val Arg Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala His Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ser Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Ala Leu Asp Tyr Trp Gly His Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  123
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  123

Thr Tyr Ala His Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp 
            20                  25                  30          


Thr Ser Thr Tyr Phe Cys 
        35              


<210>  124
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  124

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ala Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  125

Lys Ser Val Ser Thr Ser Gly Tyr Asn Phe 
1               5                   10  


<210>  126
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  126

Asn Leu Glu Ser Gly Ala Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  127
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  127

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Thr Ser 
        115         


<210>  128
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  128

Gly Tyr Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  129

Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr 
1               5                   10  


<210>  130
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  130

Met Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  131
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  131

Thr Tyr Ala Asp Asp Phe Lys Gly Arg Phe Val Phe Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Phe Cys 
        35              


<210>  132
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  132

Trp Gly Gln Gly Thr Ser Val Thr Val Thr Ser 
1               5                   10      


<210>  133
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  133

Asp Ile Ile Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  134
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  134

Asp Ile Ile Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  135

Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  136
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = Q or R

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = G or A

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa = I or V

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = Y or F

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = V or G

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = T or I

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = E or D

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = L or F

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = S or V

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa = W or Y

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = absent or G

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa = D or E

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa = W, F or Y

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = D or E

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = D, E or G

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = G or S

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = absent or I

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa = Y, W or absent

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = D or P

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa = T, L or A

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa = S or A

<400>  136

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Xaa 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Tyr 
            20                  25                  30          


Val Xaa His Trp Val Lys Gln Lys Pro Gly Xaa Gly Leu Glu Trp Ile 
        35                  40                  45              


Xaa Tyr Xaa Leu Pro Xaa Asn Asp Xaa Xaa Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Xaa Thr Ala Tyr 
65                  70                  75                  80  


Met Xaa Xaa Ser Xaa Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Xaa Xaa Thr Val Ser Xaa 
        115                 120     


<210>  137
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = S or N

<400>  137

Gly Tyr Thr Phe Thr Xaa Tyr Val 
1               5               


<210>  138
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = I or V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Y or F

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = V or G

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = T or I

<400>  138

Xaa Leu Pro Xaa Asn Asp Xaa Xaa 
1               5               


<210>  139
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = W or Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = absent or G

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = D or E

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = W, F or Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = D or E

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = D, E or G

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = G or S

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = absent or I

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Y, W or absent

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = D or P

<400>  139

Ala Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Tyr 
1               5                   10                  


<210>  140
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = A or S

<400>  140

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Xaa 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  141
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Q or R

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = G or A

<400>  141

Xaa His Trp Val Lys Gln Lys Pro Gly Xaa Gly Leu Glu Trp Ile Xaa 
1               5                   10                  15      


Tyr 
    


<210>  142
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = E or D

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = L or F

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = S or V

<400>  142

Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Xaa Thr Ala Tyr Met Xaa Xaa Ser Xaa Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  143
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = T, L or A

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = S or A

<400>  143

Trp Gly Gln Gly Thr Xaa Xaa Thr Val Ser Xaa 
1               5                   10      


<210>  144
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = K or M

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = V, I or M

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = Y or R

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa = K or E

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = D or H

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = A or V

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = N or T

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = N or D

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = A or G

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = L or M

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = Q or H

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa = S or T

<400>  144

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Xaa Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Xaa Xaa Xaa Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Xaa Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Xaa Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Xaa Phe Ser Leu Glu Thr Ser Ala Xaa Xaa Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Xaa Leu Lys Xaa Glu Asp Thr Xaa Thr Tyr Phe Cys 
                85                  90                  95      


Xaa Ile Ser Tyr Tyr Tyr Xaa Xaa Asp Tyr Trp Gly Xaa Gly Thr Ser 
            100                 105                 110         


Val Thr Val Xaa Ser 
        115         


<210>  145
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = S or T

<400>  145

Gly Tyr Thr Phe Thr Asp Tyr Xaa 
1               5               


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = A or G

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = L or M

<400>  146

Xaa Ile Ser Tyr Tyr Tyr Xaa Xaa Asp Tyr 
1               5                   10  


<210>  147
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = K or M

<400>  147

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Xaa Ala Ser 
            20                  25  


<210>  148
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = V, I or M

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Y or R

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = K or E

<400>  148

Xaa Xaa Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Xaa Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  149
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = D or H

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = A or V

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = N or T

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = N or D

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = A or S

<400>  149

Thr Tyr Ala Xaa Asp Phe Lys Gly Arg Phe Xaa Phe Ser Leu Glu Thr 
1               5                   10                  15      


Ser Ala Xaa Xaa Ala Tyr Leu Gln Ile Asn Xaa Leu Lys Xaa Glu Asp 
            20                  25                  30          


Thr Xaa Thr Tyr Phe Cys 
        35              


<210>  150
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Q or H

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = S or T

<400>  150

Trp Gly Xaa Gly Thr Ser Val Thr Val Xaa Ser 
1               5                   10      


<210>  151
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = T or A

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = G or V

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa = H or Y

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = L or F

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = V or A

<400>  151

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Xaa Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Xaa Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Xaa Tyr Xaa Phe Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Xaa Ala Ser Asn Leu Glu Ser Gly Xaa Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = G or V

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = S or N

<400>  152

Lys Ser Val Ser Thr Ser Xaa Tyr Xaa Phe 
1               5                   10  


<210>  153
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = L or F

<400>  153

Xaa Ala Ser 
1           


<210>  154
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = T or A

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = S or T

<400>  154

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Xaa Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Xaa Cys Arg Ala Ser 
            20                  25      


<210>  155
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = H or Y

<400>  155

Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  156
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = V or A

<400>  156

Asn Leu Glu Ser Gly Xaa Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  157
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  157

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Thr Tyr Arg Gly His Ser Asp Thr Tyr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  158
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  158

Gly Gly Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  159
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  159

Thr Tyr Arg Gly His Ser Asp Thr 
1               5               


<210>  160
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  160

Ala Arg Gly Ala Ile Tyr Asp Gly Tyr Asp Val Leu Asp Asn 
1               5                   10                  


<210>  161
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  161

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  162
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  162

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Ala 
    


<210>  163
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  163

Tyr Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Ala Asp Lys 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  164
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  164

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  165
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  165

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  166
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  166

Gln Gln Tyr Arg Lys Leu Pro Trp Thr 
1               5                   


<210>  167
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  167

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser 
            20                  25      


<210>  168
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  168

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  169
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  169

Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  170

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  171
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            


<210>  172
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val 
    290         


<210>  173
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 


<210>  174
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn 
305                 310     


<210>  175
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  175

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val 
        115                 120                 125             


Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile 
    130                 135                 140                 


Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala 
                165                 170                 175     


Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu 
            180                 185                 190         


Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr 
        195                 200                 205             


Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu 
    210                 215                 220                 


Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu 
225                 230                 235                 240 


Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly 
                245                 250                 255     


Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys 
            260                 265                 270         


Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala Val 
        275                 280                 285             


Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn Asp 
    290                 295                 300                 


Glu 
305 


<210>  176
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  176

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val 
        115                 120                 125             


Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile 
    130                 135                 140                 


Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala 
                165                 170                 175     


Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu 
            180                 185                 190         


Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr 
        195                 200                 205             


Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu 
    210                 215                 220                 


Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu 
225                 230                 235                 240 


Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly 
                245                 250                 255     


Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys 
            260                 265                 270         


Phe Val 
        


<210>  177
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  177

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val 
        115                 120                 125             


Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile 
    130                 135                 140                 


Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala 
                165                 170                 175     


Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu 
            180                 185                 190         


Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr 
        195                 200                 205             


Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu 
    210                 215                 220                 


Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu 
225                 230                 235                 240 


Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly 
                245                 250                 255     


Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys 
            260                 265                 270         


Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn Asn 
        275                 280                 285         


<210>  178
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  178

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu Ile Val 
        115                 120                 125             


Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe Gly Ile 
    130                 135                 140                 


Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr Ile Ala 
145                 150                 155                 160 


Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val Gly Ala 
                165                 170                 175     


Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr Gly Leu 
            180                 185                 190         


Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His Tyr Tyr 
        195                 200                 205             


Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala Ile Leu 
    210                 215                 220                 


Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu Ser Leu 
225                 230                 235                 240 


Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile Ser Gly 
                245                 250                 255     


Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr Met Lys 
            260                 265                 270         


Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala Val 
        275                 280                 285             


Glu Glu Pro Leu Asn 
    290             


<210>  179
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  179

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile 
            100                 105                 


<210>  180
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  180

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu 
        115                 120             


<210>  181
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  181

Asn Ile Leu Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp 
1               5                   10                  15      


Gly Gln Phe Gly Ile 
            20      


<210>  182
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  182

Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
1               5                   10                  


<210>  183
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  183

Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
1               5                   10                  15      


Gly Ala Ile Leu Phe 
            20      


<210>  184
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  184

Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala 
1               5                   10  


<210>  185
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  185

Thr Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu 
1               5                   10                  15      


His Tyr Tyr Val Phe 
            20      


<210>  186
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  186

Ser Thr Ala Ile Gly Leu Thr 
1               5           


<210>  187
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  187

Ser Phe Val Ile Ala Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu 
1               5                   10                  15      


Ala Val Val Gly Leu 
            20      


<210>  188
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  188

Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly 
1               5                   10          


<210>  189
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  189

Pro Leu Leu Ile Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu 
1               5                   10                  15      


Gly Leu Val Tyr Met 
            20      


<210>  190
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  190

Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala 
1               5                   10                  15      


Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met Asn 
            20                  25                  30          


Asp Glu 
        


<210>  191
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  191

Val Lys Trp Lys Phe Lys Gly Arg Asp Ile 
1               5                   10  


<210>  192
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  192

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Ser Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  193
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  193

Ile Asn Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  194
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  194

Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr 
1               5                   10  


<210>  195
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  195

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser 
            20                  25  


<210>  196
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  196

Ile His Trp Val Arg Gln Lys Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  197
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  197

Lys Ser Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Thr Ser Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  198
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  198

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  199
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  199

Gln His Leu Glu Tyr Ser Asn Gly Tyr Ser Tyr 
1               5                   10      


<210>  200
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  200

Lys Ile Ser 
1           


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  201

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  202
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  202

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  203
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  203

Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  204
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  204

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Ser Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Thr Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  205
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  205

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  206
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  206

Lys Ser Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Thr Ser Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  207
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  207

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Ser Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  208
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  208

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  209
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  209

Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  210
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  210

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
            20                  25                  30          


Val Tyr Phe Cys 
        35      


<210>  211
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  211

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Ser Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ser Asp Lys Ser Ser Thr Ser Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  212
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  212

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  213
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  213

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Ser Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  214
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  214

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Ser Asn Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val 
    


<210>  215
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  215

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val 
    


<210>  216
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  216

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  217
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  217

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Gln Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  218
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  218

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Thr Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  219
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  219

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  220
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  220

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Gly 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  221
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  221

Gly Tyr Thr Phe Thr Gly Tyr Val 
1               5               


<210>  222
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  222

Ile Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  223
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  223

Gln His Leu Glu Tyr Ser Gln Gly Tyr Ser Tyr 
1               5                   10      


<210>  224
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  224

Gln His Leu Glu Tyr Ser Thr Gly Tyr Ser Tyr 
1               5                   10      


<210>  225
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  225

Lys Val Ser 
1           


<210>  226
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  226

Ser Gln Gly Thr His Val Pro Tyr Thr 
1               5                   


<210>  227
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  227

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  228
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  228

Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  229
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  229

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  230
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  230

Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  231
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  231

Lys Ser Asn Glu Lys Phe Lys Gly Arg Val Thr Leu Thr Ser Asp Lys 
1               5                   10                  15      


Ser Ser Thr Ser Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  232
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  232

Lys Ser Asn Glu Lys Phe Lys Gly Arg Val Thr Leu Thr Ser Asp Thr 
1               5                   10                  15      


Ser Thr Thr Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  233
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  233

Lys Ser Asn Glu Lys Phe Gln Gly Arg Val Thr Leu Thr Ser Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  234
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  234

Lys Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ser Asp Thr 
1               5                   10                  15      


Ser Thr Thr Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  235
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  235

Asn Tyr Ala Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ser Asp Thr 
1               5                   10                  15      


Ser Thr Thr Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  236
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  236

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  237

Trp Gly Gln Gly Thr Leu Val 
1               5           


<210>  238
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  238

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser 
            20                  25      


<210>  239
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  239

Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  240
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  240

Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  241
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  241

Asn Arg Asp Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  242
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  242

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  243
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = N or G

<400>  243

Gly Tyr Thr Phe Thr Xaa Tyr Val 
1               5               


<210>  244
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = D or G

<400>  244

Ile Asn Pro Tyr Asn Xaa Gly Thr 
1               5               


<210>  245
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = N, Q or T

<400>  245

Gln His Leu Glu Tyr Ser Xaa Gly Tyr Ser Tyr 
1               5                   10      


<210>  246
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = I or V

<400>  246

Lys Xaa Ser 
1           


<210>  247
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = S or G

<400>  247

Ser Gln Xaa Thr His Val Pro Tyr Thr 
1               5                   


<210>  248
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = I or M

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Q or K

<400>  248

Xaa His Trp Val Arg Gln Ala Pro Gly Xaa Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  249
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = K or N

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = S or Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = N or A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = T or K

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = E or D

<400>  249

Xaa Xaa Xaa Xaa Lys Phe Xaa Arg Val Thr Leu Thr Ser Asp Xaa Ser 
1               5                   10                  15      


Xaa Ser Xaa Ala Tyr Met Glu Leu Ser Xaa Leu Arg Ser Xaa Asp Thr 
            20                  25                  30          


Ala Val Tyr Tyr Cys 
        35          


<210>  250
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = T or absent

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = V or absent

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = S or absent

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = S or absent

<400>  250

Trp Gly Gln Gly Thr Leu Val Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  251
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = D or F

<400>  251

Asn Arg Xaa Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  252
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = N or G

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = I or M

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = Q or K

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = D or G

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = K or N

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = S or Y

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa = N or A

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = T or K

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa = E or D

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa = T or absent

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa = V or absent

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa = S or absent

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa = S or absent

<400>  252

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Xaa Tyr 
            20                  25                  30          


Val Xaa His Trp Val Arg Gln Ala Pro Gly Xaa Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Xaa Gly Thr Xaa Xaa Xaa Xaa Lys Phe 
    50                  55                  60                  


Xaa Gly Arg Val Thr Leu Thr Ser Asp Xaa Ser Xaa Ser Xaa Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Xaa Leu Arg Ser Xaa Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Xaa Xaa Xaa Xaa 
        115         


<210>  253
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = N, Q or T

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = I or V

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = D or F

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa = S or G

<400>  253

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Xaa Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Xaa Ser Asn Arg Xaa Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Xaa 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  254
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  254

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  255
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  255

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  256
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  256

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10          


<210>  257
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  257

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  258
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  258

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  259
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  259

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  260
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  260

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  261
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  261

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  262
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  262

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  263
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  263

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  264
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  264

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  265
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  265

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  266
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  266

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  267
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  267

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Asn Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  268
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  268

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
1               5                   10          


<210>  269
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  269

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
        115                 120                 125             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  270
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  270

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  271
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  271

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  272
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  272

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  273
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  273

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  274
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  274

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  275
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  275

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
        115                 120                 125             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  276
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  276

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  277
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  277

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  278
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  278

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  279
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  279

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  280
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  280

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  281
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  281

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  282
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  282

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Asn Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
        115                 120                 125             


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
    130                 135                 140                 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
145                 150                 155                 160 


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
                165                 170                 175     


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
            180                 185                 190         


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
        195                 200                 205             


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
    210                 215                 220                 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
225                 230                 


<210>  283
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  283

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Leu 
                245         


<210>  284
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  284

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln His Ser Val Leu His Leu Val Pro Ile Asn 
                85                  90                  95      


Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro 
            100                 105                 110         


Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg 
        115                 120                 125             


Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln 
    130                 135                 140                 


Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly 
145                 150                 155                 160 


Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro 
                165                 170                 175     


Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His 
            180                 185                 190         


Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu 
        195                 200                 205             


Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
    210                 215                 220         


<210>  285
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  285

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                165                 170                 175     


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            180                 185                 190         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        195                 200                 205             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    210                 215                 220                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
225                 230                 235                 240 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                245                 250                 255     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            260                 265                 270         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        275                 280                 285             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    290                 295                 300                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
305                 310                 315                 320 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                325                 330 


<210>  286
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  286

Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp Leu 
1               5                   10                  15      


Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu Leu 
            20                  25                  30          


Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg Leu 
        35                  40                  45              


Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp Gln 
    50                  55                  60                  


Ser Leu Pro Glu Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala 
65                  70                  75                  80  


Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala 
                85                  90                  95      


Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile 
            100                 105                 110         


Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp 
        115                 120                 125             


Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg 
    130                 135                 140                 


Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp 
145                 150                 155                 160 


Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln 
                165                 170                 175     


Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn 
            180                 185                 190         


Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
        195                 200                 205 


<210>  287
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  287

Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      


Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          


Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              


Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  


Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  


Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      


Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         


Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             


Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 


Lys Leu 
145     


<210>  288
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  288

Ala Val Leu Thr Gln Lys Gln Lys Asn Asp Ser Asp Val Thr Glu Val 
1               5                   10                  15      


Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
            20                  25                  30          


Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
        35                  40                  45              


Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
    50                  55                  60                  


Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
65                  70                  75                  80  


Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
                85                  90                  95      


Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
            100                 105                 110         


Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
        115                 120                 125             


Lys Leu 
    130 


<210>  289
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  289

Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      


Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          


Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              


Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  


Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  


Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      


Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         


Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             


Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Leu 
    130                 135                 140             


<210>  290
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  290

Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      


Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          


Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              


Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  


Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  


Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      


Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         


Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             


Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 


Lys Leu 
145     


<210>  291
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  291

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  292
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  292

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr 
    130                 135                 140                 


Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu 
145                 150                 155                 160 


Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile 
                165                 170                 175     


Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu 
            180                 185                 190         


Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val 
        195                 200                 205             


Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn 
    210                 215                 220                 


Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu 
225                 230                 235                 240 


Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp 
                245                 250                 255     


Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
            260                 265     


<210>  293
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  293

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Phe Ile Tyr 
                


<210>  294
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  294

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys 
        35                  40                  45      


<210>  295
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  295

Leu Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr 
1               5                   10                  15      


Val Val Ser Phe Tyr 
            20      


<210>  296
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  296

Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg Ala Glu Leu 
1               5                   10                  15      


Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly Ala Pro Lys 
            20                  25                  30          


Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu Lys Ile Phe 
        35                  40                  45              


Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn Ser Arg Asn 
    50                  55                  60                  


Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu 
65                  70                  75                  80  


Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr 
                85                  90                  95      


Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu 
            100                 105                 110         


Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile 
        115                 120                 125             


Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu 
    130                 135                 140                 


Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val 
145                 150                 155                 160 


Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn 
                165                 170                 175     


Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu 
            180                 185                 190         


Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp 
        195                 200                 205             


Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
    210                 215             


<210>  297
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  297

Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg Ala Glu Leu 
1               5                   10                  15      


Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly Ala Pro Lys 
            20                  25                  30          


Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu Lys Ile Phe 
        35                  40                  45              


Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn Ser Arg Asn 
    50                  55                  60                  


Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr Thr Phe Val 
65                  70                  75                  80  


Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu 
                85                  90                  95      


Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln 
            100                 105                 110         


Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg 
        115                 120                 125             


Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe 
    130                 135                 140                 


Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr 
145                 150                 155                 160 


Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala 
                165                 170                 175     


Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe 
            180                 185                 190         


Phe Gly Ala Leu Lys Leu Leu 
        195                 


<210>  298
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  298

Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg Ala Glu Leu 
1               5                   10                  15      


Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly Ala Pro Lys 
            20                  25                  30          


Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu Lys Ile Phe 
        35                  40                  45              


Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn Ser Arg Asn 
    50                  55                  60                  


Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu 
65                  70                  75                  80  


Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Phe Ile 
                85                  90                  95      


Tyr 
    


<210>  299
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  299

Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu 
1               5                   10                  15      


Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe 
            20                  25                  30          


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys 
        35                  40                  45              


Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly 
    50                  55                  60                  


Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln 
65                  70                  75                  80  


Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
                85                  90                  95      


Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys 
            100                 105                 110         


Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu 
        115                 120                 125             


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr 
    130                 135                 140                 


Phe Phe Gly Ala Leu Lys Leu Leu 
145                 150         


<210>  300
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  300

Ala Val Gln Gly Pro Glu Glu Thr Gly Ser Tyr Thr Phe Val Pro Trp 
1               5                   10                  15      


Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys 
            20                  25                  30          


Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu 
        35                  40                  45              


Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys 
    50                  55                  60                  


Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys 
65                  70                  75                  80  


Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala 
                85                  90                  95      


Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro 
            100                 105                 110         


Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly 
        115                 120                 125             


Ala Leu Lys Leu Leu 
    130             


<210>  301
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  301

Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu 
1               5                   10                  15      


Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Phe Ile Tyr 
            20                  25                  30      


<210>  302
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  302

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  303
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  303

Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  304
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  304

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Val Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  305
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  305

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  306
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  306

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Leu Pro Tyr Asn Asp Val Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Phe Asp Glu Gly Ile Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  307
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  307

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp His Ala Ser Val Ser Cys Arg Ser Ser Gln Ser Ile Val His Thr 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  308
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  308

Glu Val Met Leu Val Asp Ser Gly Gly Asn Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Val Gly Thr Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Arg His Lys Tyr Gly Tyr Asp Asp Pro Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  309
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  309

Gln Leu Val Leu Thr Gln Ser Ser Ser Ala Ser Phe Ser Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Gln His Ser Thr Tyr Thr 
            20                  25                  30          


Ile Glu Trp Tyr Gln Gln Gln Pro Leu Lys Pro Pro Lys Tyr Val Met 
        35                  40                  45              


Glu Leu Lys Lys Asp Gly Ser His Ser Thr Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ser Ile Ser 
65                  70                  75                  80  


Asn Ile Gln Ala Glu Asp Glu Ala Ile Tyr Ile Cys Gly Val Gly Asp 
                85                  90                  95      


Thr Val Lys Glu Gln Phe Val Tyr Val Phe Gly Gly Gly Thr Lys Val 
            100                 105                 110         


Thr Val Leu Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro 
        115                 120                 125             


Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu 
    130                 135                 140                 


Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp 
145                 150                 155                 160 


Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln 
                165                 170                 175     


Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu 
            180                 185                 190         


Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly 
        195                 200                 205             


Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215                 220     


<210>  310
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  310

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Ile Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Phe Ser Leu Thr Ser Glu Asp Ser Thr Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  311
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  311

Asp Ile Gln Met Thr Gln Thr Ser Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ile Tyr 
            20                  25                  30          


Leu Asn Trp Phe Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Arg Leu His Pro Gly Val Pro Ser Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser His Leu Glu His 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  312
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  312

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  313
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  313

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  314
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  314

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Val Arg Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala His Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ser Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Ala Leu Asp Tyr Trp Gly His Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  315
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  315

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Ala Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  316
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  316

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Val Arg Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Ala Leu Asp Tyr Trp Gly His Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  317
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  317

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Val Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  318
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  318

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Thr Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  319
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  319

Asp Ile Ile Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  320
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  320

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Arg Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  321
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  321

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Phe Ser Val Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ala Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  322
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  322

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Val Leu Pro Tyr Asn Asp Val Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Gly Asp Phe Asp Glu Gly Ile Trp Phe Pro Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  323
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  323

Glu Val Met Leu Val Asp Ser Gly Gly Asn Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Thr Val Gly Thr Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ser Arg His Lys Tyr Gly Tyr Asp Asp Pro Ser Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  324
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  324

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Ile Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Asp Ser Ile Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Phe Ser Leu Thr Ser Glu Asp Ser Thr Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  325
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  325

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Ser Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Thr Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  326
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  326

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Val Arg Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala His Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asp Glu Asp Thr Ser Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Ala Leu Asp Tyr Trp Gly His Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  327
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  327

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Met Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Val Arg Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Ala Leu Asp Tyr Trp Gly His Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  328
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  328

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Val Phe Ser Leu Glu Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Thr Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  329
<211>  478
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  329

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln His Leu Glu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Val 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Tyr Ile Asn Pro Tyr Asn Gly Gly Thr Asn Tyr Ala Gln Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Leu Thr Ser Asp Thr Ser Thr Thr Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Arg Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ser Gly Gly Tyr Tyr Thr Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Gly Gly Arg Pro Lys Ser Ala Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
    370                 375                 380                 


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            420                 425                 430         


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475             


<210>  330
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  330

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210>  331
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  331

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Trp Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe 
            20                  25                  30          


Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly 
        35                  40                  45              


Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
    50                  55                  60                  


Pro Val Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val 
65                  70                  75                  80  


Glu Asn Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg 
                85                  90                  95      


Gly Ser Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp 
            100                 105                 110         


Gln Val Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val 
        115                 120                 125             


Leu Cys Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly 
    130                 135                 140                 


Asp Pro Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala 
145                 150                 155                 160 


Lys Ser Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr 
                165                 170                 175     


Ser Pro Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg 
            180                 185                 190         


Ala Pro Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr 
        195                 200                 205             


Cys Ala Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro 
    210                 215                 220                 


Cys Pro His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala 
225                 230                 235                 240 


Gln Glu Gly Gly Pro Gly Ala 
                245         


<210>  332
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  332

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Pro Arg Gly Cys Pro Ala Pro Gly Thr Arg Lys 
145                 150                 155                 160 


Ser Phe Trp Asp Lys Glu Asn Phe Gln Gly Glu Gly Phe His Leu Gly 
                165                 170                 175     


<210>  333
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  333

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser 
                165 


<210>  334
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  334

Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
1               5                   10                  15      


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
            20                  25                  30          


Phe Cys Arg 
        35  


<210>  335
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  335

Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp 
1               5                   10                  15      


Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala 
            20                  25                  30          


Tyr Phe Cys 
        35  


<210>  336
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  336

Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys Cys Phe Leu Val Ala 
1               5                   10                  15      


Val Ala Cys Phe Leu 
            20      


<210>  337
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  337

Lys Lys Arg Gly Asp Pro Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg 
1               5                   10                  15      


Gln Ser Pro Ala Lys Ser Ser Gln Asp His Ala Met Glu Ala Gly Ser 
            20                  25                  30          


Pro Val Ser Thr Ser Pro Glu Pro Val Glu Thr Cys Ser Phe Cys Phe 
        35                  40                  45              


Pro Glu Cys Arg Ala Pro Thr Gln Glu Ser Ala Val Thr Pro Gly Thr 
    50                  55                  60                  


Pro Asp Pro Thr Cys Ala Gly Arg Trp Gly Cys His Thr Arg Thr Thr 
65                  70                  75                  80  


Val Leu Gln Pro Cys Pro His Ile Pro Asp Ser Gly Leu Gly Ile Val 
                85                  90                  95      


Cys Val Pro Ala Gln Glu Gly Gly Pro Gly Ala 
            100                 105         


<210>  338
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  338

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Asn Tyr Ala Gln Asp Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  339
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  339

Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  340
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  340

Asn Tyr Ala Gln Asp Val Gln Gly Arg Phe Thr Met Thr Leu Asp Thr 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  341
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  341

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  342
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  342

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser 
            20                  25      


<210>  343
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  343

Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro Gln Leu Leu Ile 
1               5                   10                  15      


<210>  344
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  344

Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  345
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  345

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  346
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  346

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Thr Asn Tyr Ala Gln Asp Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Glu Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  347
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  347

Ile Asn Thr Glu Thr Gly Glu Thr 
1               5               


<210>  348
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  348

Asn Tyr Ala Gln Asp Phe Gln Gly Arg Val Thr Met Thr Thr Asp Thr 
1               5                   10                  15      


Glu Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  349
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  349

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Thr Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  350
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  350

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            20                  25      


<210>  351
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  351

Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  352
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  352

Asn Leu Glu Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  353
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  353

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  354
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  354

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  355
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  355

Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  356
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  356

Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  357
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  357

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  358
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  358

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  359
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  359

Val Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  360
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  360

Asn Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  361
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  361

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Thr Glu Thr Gly Glu Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  362
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  362

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  363
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  363

Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Asp 
    


<210>  364
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  364

Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  365
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  365

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  366
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  366

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  367
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  367

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  368
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  368

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Ala 
1               5                   10                  15      


Tyr 
    


<210>  369
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  369

Lys Tyr Asn Glu Lys Phe Lys Gly Arg Val Thr Met Thr Ser Asp Lys 
1               5                   10                  15      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  370
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  370

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  371
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  371

Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  372
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  372

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  373
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  373

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  374
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  374

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Ala 
1               5                   10                  15      


Tyr 
    


<210>  375
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  375

Asn Tyr Asn Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
1               5                   10                  15      


Ser Ile Ser Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  376
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  376

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Thr Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  377
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  377

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser 
            20                  25      


<210>  378
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  378

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  379
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  379

Thr Arg Phe Ser Gly Val Leu Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  380
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  380

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  381
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  381

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  382
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  382

Asn Tyr Asn Gln Lys Phe Gln Gly Arg Val Thr Met Thr Ser Asp Lys 
1               5                   10                  15      


Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  383
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  383

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  384
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  384

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  385
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  385

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
1               5                   10                  15      


Cys 
    


<210>  386
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  386

Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  387
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  387

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Tyr Asn Asp Gly Ala Asn Tyr Asn Glu Lys Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  388
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  388

Ile Leu Pro Tyr Asn Asp Gly Ala 
1               5               


<210>  389
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  389

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  390
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  390

Asn Tyr Asn Glu Lys Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  391
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  391

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ser Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  392
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  392

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ser Val Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  393
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = P or T

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa = V or F

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa = F or V

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = L or T

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa = S or E

<400>  393

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Xaa Asn Tyr Ala Gln Asp Xaa 
    50                  55                  60                  


Gln Gly Arg Xaa Thr Met Thr Xaa Asp Thr Xaa Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  394
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = P or T

<400>  394

Ile Asn Thr Glu Thr Gly Glu Xaa 
1               5               


<210>  395
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = V or F

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = F or V

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = L or T

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = S or E

<400>  395

Asn Tyr Ala Gln Asp Xaa Gln Gly Arg Xaa Thr Met Thr Xaa Asp Thr 
1               5                   10                  15      


Xaa Thr Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Arg Ser Asp Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  396
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = D or E

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = M or L

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = L or A

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = V or L

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = P or R

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = I or L

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = K or R

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = S or A

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa = L or Q

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa = P or A

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = Q or R

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = V or I

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa = D or A

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = K or T

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = V or L

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = A or P

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa = V or F

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = G or A

<220>
<221>  misc_feature
<222>  (108)..(108)
<223>  Xaa = V or L

<400>  396

Xaa Ile Val Xaa Thr Gln Xaa Pro Xaa Xaa Leu Ser Xaa Xaa Pro Gly 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Ser Cys Xaa Xaa Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Leu His Trp Tyr Xaa Gln Lys Pro Gly Gln Xaa Pro 
        35                  40                  45              


Xaa Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Xaa Gly Xaa Pro Xaa 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Xaa Ile Ser 
65                  70                  75                  80  


Arg Xaa Glu Xaa Glu Asp Xaa Xaa Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 110     


<210>  397
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = D or E

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = M or L

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = L or A

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = V or L

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = P or R

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = I or L

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = K or R

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = S or A

<400>  397

Xaa Ile Val Xaa Thr Gln Xaa Pro Xaa Xaa Leu Ser Xaa Xaa Pro Gly 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Ser Cys Xaa Xaa Ser 
            20                  25      


<210>  398
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = L or Q

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = P or A

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Q or R

<400>  398

Leu His Trp Tyr Xaa Gln Lys Pro Gly Gln Xaa Pro Xaa Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  399
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = V or I

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = D or A

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = K or T

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = V or L

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = A or P

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = V or F

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = G or A

<400>  399

Asn Leu Glu Xaa Gly Xaa Pro Xaa Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Xaa Ile Ser Arg Xaa Glu Xaa Glu Asp Xaa Xaa 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  400
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = V or L

<400>  400

Phe Gly Gln Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  401
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = G or E

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa = D or W

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = T or N

<400>  401

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Xaa Ile Asn Thr Glu Thr Gly Glu Thr Xaa Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  402
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = G or E

<400>  402

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Xaa 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  403
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = D or W

<400>  403

Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Xaa 
    


<210>  404
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = T or N

<400>  404

Xaa Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  405
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = A or V

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa = Q or K

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa = P or A

<400>  405

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  406
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = A or V

<400>  406

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Xaa Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  407
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Q or K

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = P or A

<400>  407

Val Tyr Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  408
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = V or M

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = K or N

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = K or T

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = T or I

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = V or A

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa = E or D

<400>  408

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Xaa Tyr Asn Xaa Lys Phe 
    50                  55                  60                  


Xaa Gly Arg Val Thr Met Thr Xaa Asp Xaa Ser Xaa Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Xaa Leu Arg Ser Xaa Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  409
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = V or M

<400>  409

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Xaa Ser Cys Lys Ala Ser 
            20                  25  


<210>  410
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = M or I

<400>  410

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa Ala 
1               5                   10                  15      


Tyr 
    


<210>  411
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = K or N

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = K or T

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = T or I

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = V or A

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = E or D

<400>  411

Xaa Tyr Asn Xaa Lys Phe Xaa Gly Arg Val Thr Met Thr Xaa Asp Xaa 
1               5                   10                  15      


Ser Xaa Ser Thr Xaa Tyr Met Glu Leu Ser Xaa Leu Arg Ser Xaa Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  412
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = D or L

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = L or P

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = R or P

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = N or S

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = Q or L

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa = P or S

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = T or N

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa = L or P

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = T or K

<220>
<221>  misc_feature
<222>  (82)..(84)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa = A or G

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = G or Q

<220>
<221>  misc_feature
<222>  (109)..(109)
<223>  Xaa = V or L

<400>  412

Asp Ile Val Met Thr Gln Xaa Pro Xaa Ser Leu Xaa Val Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Ala Xaa Ile Xaa Cys Lys Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Xaa Gln Lys Pro Gly Gln Xaa 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Xaa Arg Phe Ser Gly Val Xaa 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Xaa Ile 
65                  70                  75                  80  


Ser Xaa Xaa Xaa Ala Glu Asp Val Xaa Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Xaa Gly Thr Lys Xaa Glu Ile Lys 
            100                 105                 110         


<210>  413
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa= S or T

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = D or L

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = S or T

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = L or P

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = R or P

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = N or S

<400>  413

Asp Ile Val Met Thr Gln Xaa Pro Xaa Ser Leu Xaa Val Xaa Xaa Gly 
1               5                   10                  15      


Xaa Xaa Ala Xaa Ile Xaa Cys Lys Ser Ser 
            20                  25      


<210>  414
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Q or L

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = P or S

<400>  414

Leu Asn Trp Tyr Xaa Gln Lys Pro Gly Gln Xaa Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  415
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = T or N

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = L or P

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = T or K

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = A or G

<400>  415

Xaa Arg Phe Ser Gly Val Xaa Asp Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Xaa Ile Ser Xaa Xaa Xaa Ala Glu Asp Val Xaa 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  416
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = G or Q

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = V or L

<400>  416

Phe Gly Xaa Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  417
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = A or G

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = E or G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = V or L

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = K or R

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = M or L

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = K or A

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = G or A

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = T or A

<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa = F or V

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa = Q or K

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa = V or F

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = K or N

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = T or K

<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = A or L

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa = M or L

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = L or M

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = S or A

<400>  417

Gln Val Gln Leu Val Xaa Ser Gly Xaa Xaa Xaa Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Xaa Xaa Xaa Ser Cys Xaa Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Xaa Tyr Ile Leu Pro Tyr Asn Asp Gly Xaa Asn Tyr Asn Xaa Lys Xaa 
    50                  55                  60                  


Xaa Gly Arg Xaa Thr Xaa Xaa Xaa Asp Xaa Ser Xaa Xaa Thr Xaa Tyr 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Ser Leu Arg Xaa Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  418
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = T or A

<400>  418

Ile Leu Pro Tyr Asn Asp Gly Xaa 
1               5               


<210>  419
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa= A or G

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = E or G

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = L or V

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = V or L

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = K or R

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = M or L

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = K or A

<400>  419

Gln Val Gln Leu Val Xaa Ser Gly Xaa Xaa Xaa Val Xaa Pro Gly Xaa 
1               5                   10                  15      


Ser Xaa Xaa Xaa Ser Cys Xaa Ala Ser 
            20                  25  


<210>  420
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = G or A

<400>  420

Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa Xaa 
1               5                   10                  15      


Tyr 
    


<210>  421
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Q or E

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = F or V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Q or K

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = V or F

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = T or S

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = S or R

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = K or N

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa = T or K

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = A or L

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa = M or L

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = L or M

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = S or N

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = S or A

<400>  421

Asn Tyr Asn Xaa Lys Xaa Xaa Gly Arg Xaa Thr Xaa Xaa Xaa Asp Xaa 
1               5                   10                  15      


Ser Xaa Xaa Thr Xaa Tyr Xaa Xaa Xaa Xaa Ser Leu Arg Xaa Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  422
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = P or V

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = C or Y

<400>  422

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Xaa Lys Leu Leu Xaa 
        35                  40                  45              


Xaa Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  423
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = K or Q

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = A or S

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = P or V

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = M or I

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = C or Y

<400>  423

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Xaa Lys Leu Leu Xaa 
1               5                   10                  15      


Xaa 
    


<210>  424
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  424

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Asn Tyr Ala Gln Asp Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  425
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  425

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Gln Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  


Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  426
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  426

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Thr Asn Tyr Ala Gln Asp Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Glu Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  427
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  427

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Phe Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Phe Ala Ser Asn Leu Glu Thr Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  428
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  428

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  429
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  429

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  430
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  430

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Thr Glu Thr Gly Glu Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  431
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  431

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Asn Phe Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  432
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  432

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  433
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  433

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  434
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  434

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  435
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  435

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Glu Asn Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Arg Val Ser Thr Arg Phe Ser Gly Val Leu 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Gln Val 
                85                  90                  95      


Ser His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  436
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  436

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  437
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  437

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  438
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  438

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Tyr Asn Asp Gly Ala Asn Tyr Asn Glu Lys Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  439
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  439

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ser Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  440
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  440

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Asn Tyr Ala Gln Asp Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  441
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  441

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ser Ile Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Thr Asn Tyr Ala Gln Asp Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Glu Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Ile Ser Tyr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  442
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  442

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  443
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  443

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asp Ile Asn Thr Glu Thr Gly Glu Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Tyr Tyr Tyr Gly Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  444
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  444

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  445
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  445

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Phe Asn Asp Val Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Glu Trp Asp Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  446
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  446

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  447
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  447

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Tyr Ile Leu Pro Tyr Asn Asp Gly Ala Asn Tyr Asn Glu Lys Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  448
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  448

Tyr Phe Asp Ser Leu Leu 
1               5       


<210>  449
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  449

Tyr Trp Asp Pro Leu Leu 
1               5       


<210>  450
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  450

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Ala Phe Ala Ser 
1               5                   10                  15      


Gly Gly His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  451
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  451

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Ala Trp Ala Pro Gly Gly Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210>  452
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  452

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  453
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  453

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
            100                 105     


<210>  454
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  454

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Ala His Phe Arg Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Ser Asn Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Asn Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  455
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  455

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  456
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  456

Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr 
1               5                   10      


<210>  457
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  457

Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  458
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  458

Lys Tyr Ala Gln Lys Phe Gln Gly Lys Val Thr Met Thr Ser Asp Lys 
1               5                   10                  15      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  459
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  459

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Leu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  460
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  460

Gln Gln Gly Asn Leu Phe Pro Pro Thr 
1               5                   


<210>  461
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  461

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
1               5                   10                  15      


Arg 
    


<210>  462
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  462

Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  463
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  463

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  464
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  464

Ser Asp Ile Ser Asn Tyr 
1               5       


<210>  465
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  465

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  466
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  466

Gly Tyr Thr Phe Arg Asn Tyr Val 
1               5               


<210>  467
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  467

Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Trp 
    


<210>  468
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  468

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Leu Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  469
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  469

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
1               5                   10                  15      


Arg 
    


<210>  470
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  470

Leu Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  471
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  471

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met Phe Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Thr Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  472
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  472

Ile Thr Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  473
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  473

Met Phe Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  474
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  474

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  475
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  475

Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  476
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  476

Ser Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  477
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  477

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  478
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  478

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  479
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  479

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  480
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  480

Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  481
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  481

Lys Tyr Ser Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  482
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  482

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  483
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  483

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  484
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  484

Gln Asp Ile Gly Asn Tyr 
1               5       


<210>  485
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  485

Gln Gln Gly Phe Thr Phe Pro Pro Thr 
1               5                   


<210>  486
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  486

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Met 
1               5                   10                  15      


Arg 
    


<210>  487
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  487

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ala Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Arg Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  488
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  488

Gln Gln Gly Asn Arg Phe Pro Pro Thr 
1               5                   


<210>  489
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  489

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ala Ala Ser 
            20                  25      


<210>  490
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa = T or R

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = H or F

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = K or A

<220>
<221>  MISC_FEATURE
<222>  (44)..(44)
<223>  Xaa = G or R

<220>
<221>  MISC_FEATURE
<222>  (50)..(50)
<223>  Xaa = Y or W

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa = L or T

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa = A or S

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa = M or I

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa = S or R

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa = K or T

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa = T or A

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa = V or A

<220>
<221>  MISC_FEATURE
<222>  (87)..(87)
<223>  Xaa = T or R

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa = Y or W

<220>
<221>  MISC_FEATURE
<222>  (113)..(113)
<223>  Xaa = L or T

<400>  490

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Xaa Asn Tyr 
            20                  25                  30          


Val Met Xaa Trp Val Xaa Gln Xaa Pro Gly Gln Xaa Leu Glu Trp Met 
        35                  40                  45              


Gly Xaa Ile Xaa Pro Tyr Asn Asp Gly Thr Lys Tyr Xaa Gln Lys Phe 
    50                  55                  60                  


Gln Gly Xaa Val Thr Xaa Thr Xaa Asp Xaa Ser Xaa Ser Thr Xaa Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Xaa Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Xaa Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Xaa Val Thr Val Ser Ser 
        115             


<210>  491
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = T or R

<400>  491

Gly Tyr Thr Phe Xaa Asn Tyr Val 
1               5               


<210>  492
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = L or T

<400>  492

Ile Xaa Pro Tyr Asn Asp Gly Thr 
1               5               


<210>  493
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Y or W

<400>  493

Ala Arg Tyr Asp Xaa Glu Gly Ser Phe Asp Tyr 
1               5                   10      


<210>  494
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = H or F

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = K or R

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = K or A

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = G or R

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = Y or W

<400>  494

Met Xaa Trp Val Xaa Gln Xaa Pro Gly Gln Xaa Leu Glu Trp Met Gly 
1               5                   10                  15      


Xaa 
    


<210>  495
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = A or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = K or R

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = M or I

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = S or R

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa = K or T

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa = T or A

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa = V or A

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa = T or R

<400>  495

Lys Tyr Xaa Gln Lys Phe Gln Gly Xaa Val Thr Xaa Thr Xaa Asp Xaa 
1               5                   10                  15      


Ser Xaa Ser Thr Xaa Tyr Met Glu Leu Ser Ser Leu Xaa Ser Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  496
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = L or T

<400>  496

Trp Gly Gln Gly Thr Xaa Val Thr Val Ser Ser 
1               5                   10      


<210>  497
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = R or A

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = Q or S

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = S or G

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = N or S

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = P or V

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = R or C

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa = R or L

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = L or F

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = Q or P

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa = N or F

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = T, L or R

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa = F or S

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = V or L

<400>  497

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Xaa Ala Ser Xaa Asp Ile Xaa Asn Tyr 
            20                  25                  30          


Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Xaa Lys Leu Leu Met 
        35                  40                  45              


Xaa Tyr Thr Ser Xaa Xaa His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Xaa Xaa 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Xaa Xaa Phe Pro Pro 
                85                  90                  95      


Thr Xaa Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
            100                 105         


<210>  498
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = Q or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = S or G

<400>  498

Xaa Asp Ile Xaa Asn Tyr 
1               5       


<210>  499
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = N or F

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = T, L or R

<400>  499

Gln Gln Gly Xaa Xaa Phe Pro Pro Thr 
1               5                   


<210>  500
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = R or A

<400>  500

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Xaa Ala Ser 
            20                  25      


<210>  501
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = N or S

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = P or V

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = R or C

<400>  501

Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Xaa Lys Leu Leu Met 
1               5                   10                  15      


Xaa 
    


<210>  502
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = R or L

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = L or F

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = E or Q

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = Q or P

<400>  502

Xaa Xaa His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Xaa Xaa Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  503
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = F or S

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = V or L

<400>  503

Xaa Gly Gly Gly Thr Lys Xaa Glu Ile Lys 
1               5                   10  


<210>  504
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  504

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  505
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  505

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Leu Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  506
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  506

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  507
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  507

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  508
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  508

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Leu Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  509
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  509

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met Phe Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Thr Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  510
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  510

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Ser Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  511
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  511

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  512
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  512

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Cys Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  513
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  513

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  514
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  514

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Phe Thr Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  515
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  515

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ala Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Val Lys Leu Leu Met 
        35                  40                  45              


Arg Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Arg Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  516
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  516

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  517
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  517

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  518
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  518

Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  519
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  519

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  520
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  520

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  521
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  521

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Arg Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  522
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  522

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met Phe Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Thr Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  523
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  523

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Ser Asp Lys Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  524
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  524

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Leu Pro Tyr Asn Asp Gly Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Trp Glu Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  525
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  525

Gly Tyr Thr Phe Thr Arg Tyr Thr 
1               5               


<210>  526
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  526

Ile Asn Pro Ser Arg Gly Tyr Thr 
1               5               


<210>  527
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  527

Ala Arg Tyr Tyr Asp Asp His Tyr Cys Leu Asp Tyr 
1               5                   10          


<210>  528
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  528

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  529
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  529

Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  530
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  530

Asn Tyr Asn Gln Lys Phe Lys Asp Lys Ala Thr Leu Thr Thr Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Tyr Cys 
        35              


<210>  531
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  531

Ser Ser Val Ser Tyr 
1               5   


<210>  532
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  532

Asp Thr Ser 
1           


<210>  533
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  533

Gln Gln Trp Ser Ser Asn Pro Phe Thr 
1               5                   


<210>  534
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  534

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  535
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  535

Met Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  536
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  536

Lys Leu Ala Ser Gly Val Pro Ala His Phe Arg Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Ser Tyr Ser Leu Thr Ile Ser Gly Met Glu Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  537
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  537

Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn 
1               5                   10  


<210>  538
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  538

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120                 125 


<210>  539
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  539

Gly Phe Thr Phe Asn Thr Tyr Ala 
1               5               


<210>  540
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  540

Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  541
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  541

Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe Ala Tyr 
1               5                   10                  15      


<210>  542
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  542

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  543
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  543

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Arg 
    


<210>  544
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  544

Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys 
        35              


<210>  545
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  545

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  546
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  546

Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   


<210>  547
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  547

Gly Thr Asn 
1           


<210>  548
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  548

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  549
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  549

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser 
            20                  25  


<210>  550
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  550

Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile 
1               5                   10                  15      


Gly 
    


<210>  551
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  551

Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly 
1               5                   10                  15      


Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala 
            20                  25                  30          


Ile Tyr Phe Cys 
        35      


<210>  552
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  552

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
1               5                   10  


<210>  553
<211>  483
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  553

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Tyr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asn Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala Val 
    130                 135                 140                 


Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr Val Thr 
145                 150                 155                 160 


Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala 
                165                 170                 175     


Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu Ile Gly 
            180                 185                 190         


Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg Phe Ser Gly Ser 
        195                 200                 205             


Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Thr Glu 
    210                 215                 220                 


Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn Leu Trp Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Val Glu Pro Lys Ser Cys 
                245                 250                 255     


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
            260                 265                 270         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        275                 280                 285             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    290                 295                 300                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
305                 310                 315                 320 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                325                 330                 335     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            340                 345                 350         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        355                 360                 365             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    370                 375                 380                 


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
385                 390                 395                 400 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                405                 410                 415     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            420                 425                 430         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
        435                 440                 445             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    450                 455                 460                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
465                 470                 475                 480 


Pro Gly Lys 
            


<210>  554
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  554

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu His Ala Cys Ile Pro Cys Gln Leu 
            20                  25  


<210>  555
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  555

Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu 
1               5                   10          


<210>  556
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  556

His Ala Cys Ile Pro Cys Gln Leu 
1               5               


<210>  557
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  557

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu 
    


<210>  558
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  558

Asp Ser Leu Leu 
1               


