                         SEQUENCE LISTING

<110>  Pfizer Inc.
 
<120>  METHODS FOR MEASURING DYSTROPHIN IN TISSUE SAMPLES

<130>  PC072658

<160>  253   

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  1

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg 
1               5                   10              


<210>  2
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  2

Trp Val Asn Ala Gln Phe Ser Lys 
1               5               


<210>  3
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  3

Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
1               5                   10                  


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  4

Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys 
1               5                   10          


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  5

Val His Ala Leu Asn Asn Val Asn Lys 
1               5                   


<210>  6
<211>  23
<212>  PRT
<213>  Homo sapien

<400>  6

Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser Thr Asp 
1               5                   10                  15      


Ile Val Asp Gly Asn His Lys 
            20              


<210>  7
<211>  16
<212>  PRT
<213>  Homo sapien

<400>  7

Leu Thr Leu Gly Leu Ile Trp Asn Ile Ile Leu His Trp Gln Val Lys 
1               5                   10                  15      


<210>  8
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  8

Asn Ile Met Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys 
1               5                   10              


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  9

Ile Leu Leu Ser Trp Val Arg 
1               5           


<210>  10
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  10

Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala Thr 
1               5                   10                  15      


Gln Arg 
        


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  11

Leu Glu His Ala Phe Asn Ile Ala Arg 
1               5                   


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  12

Tyr Gln Leu Gly Ile Glu Lys 
1               5           


<210>  13
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  13

Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp Lys 
1               5                   10                  


<210>  14
<211>  26
<212>  PRT
<213>  Homo sapien

<400>  14

Glu Glu His Phe Gln Leu His His Gln Met His Tyr Ser Gln Gln Ile 
1               5                   10                  15      


Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
            20                  25      


<210>  15
<211>  17
<212>  PRT
<213>  Homo sapien

<400>  15

Ser Tyr Ala Tyr Thr Gln Ala Ala Tyr Val Thr Thr Ser Asp Pro Thr 
1               5                   10                  15      


Arg 
    


<210>  16
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  16

Ser Pro Phe Pro Ser Gln His Leu Glu Ala Pro Glu Asp Lys 
1               5                   10                  


<210>  17
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  17

Ser Phe Gly Ser Ser Leu Met Glu Ser Glu Val Asn Leu Asp Arg 
1               5                   10                  15  


<210>  18
<211>  33
<212>  PRT
<213>  Homo sapien

<400>  18

Tyr Gln Thr Ala Leu Glu Glu Val Leu Ser Trp Leu Leu Ser Ala Glu 
1               5                   10                  15      


Asp Thr Leu Gln Ala Gln Gly Glu Ile Ser Asn Asp Val Glu Val Val 
            20                  25                  30          


Lys 
    


<210>  19
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  19

Asp Gln Phe His Thr His Glu Gly Tyr Met Met Asp Leu Thr Ala His 
1               5                   10                  15      


Gln Gly Arg 
            


<210>  20
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  20

Val Gly Asn Ile Leu Gln Leu Gly Ser Lys 
1               5                   10  


<210>  21
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  21

Leu Ile Gly Thr Gly Lys 
1               5       


<210>  22
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  22

Leu Ser Glu Asp Glu Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu 
1               5                   10                  15      


Asn Ser Arg 
            


<210>  23
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  23

Val Ala Ser Met Glu Lys 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  24

Gln Ser Asn Leu His Arg 
1               5       


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  25

Val Leu Met Asp Leu Gln Asn Gln Lys 
1               5                   


<210>  26
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  26

Glu Leu Asn Asp Trp Leu Thr Lys 
1               5               


<210>  27
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  27

Met Glu Glu Glu Pro Leu Gly Pro Asp Leu Glu Asp Leu Lys 
1               5                   10                  


<210>  28
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  28

Gln Val Gln Gln His Lys 
1               5       


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  29

Val Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg 
1               5                   10          


<210>  30
<211>  28
<212>  PRT
<213>  Homo sapien

<400>  30

Val Asn Ser Leu Thr His Met Val Val Val Val Asp Glu Ser Ser Gly 
1               5                   10                  15      


Asp His Ala Thr Ala Ala Leu Glu Glu Gln Leu Lys 
            20                  25              


<210>  31
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  31

Trp Ala Asn Ile Cys Arg 
1               5       


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  32

Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
1               5                   10  


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  33

Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser Glu Lys 
1               5                   10                  15  


<210>  34
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  34

Glu Asp Ala Val Asn Lys 
1               5       


<210>  35
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  35

Ile His Thr Thr Gly Phe Lys 
1               5           


<210>  36
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  36

Asp Gln Asn Glu Met Leu Ser Ser Leu Gln Lys 
1               5                   10      


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  37

Gln Asp Leu Leu Ser Thr Leu Lys 
1               5               


<210>  38
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  38

Thr Glu Ala Trp Leu Asp Asn Phe Ala Arg 
1               5                   10  


<210>  39
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  39

Cys Trp Asp Asn Leu Val Gln Lys 
1               5               


<210>  40
<211>  31
<212>  PRT
<213>  Homo sapien

<400>  40

Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr Gln Pro Ser Leu 
1               5                   10                  15      


Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val Thr Thr Arg 
            20                  25                  30      


<210>  41
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  41

Glu Gln Ile Leu Val Lys 
1               5       


<210>  42
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  42

His Ala Gln Glu Glu Leu Pro Pro Pro Pro Pro Gln Lys 
1               5                   10              


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  43

Gln Ile Thr Val Asp Ser Glu Ile Arg 
1               5                   


<210>  44
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  44

Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr Arg 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  45

Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg 
1               5                   10                  


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  46

Glu Gly Asn Phe Ser Asp Leu Lys 
1               5               


<210>  47
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  47

Val Asn Ala Ile Glu Arg 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  48

Leu Gln Asp Ala Ser Arg 
1               5       


<210>  49
<211>  20
<212>  PRT
<213>  Homo sapien

<400>  49

Ser Ala Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala 
1               5                   10                  15      


Asp Ser Ile Lys 
            20  


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  50

Gln Ala Ser Glu Gln Leu Asn Ser Arg 
1               5                   


<210>  51
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  51

Trp Ile Glu Phe Cys Gln Leu Leu Ser Glu Arg 
1               5                   10      


<210>  52
<211>  32
<212>  PRT
<213>  Homo sapien

<400>  52

Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile Ile Ala Phe Tyr Asn Gln 
1               5                   10                  15      


Leu Gln Gln Leu Glu Gln Met Thr Thr Thr Ala Glu Asn Trp Leu Lys 
            20                  25                  30          


<210>  53
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  53

Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr Ala Ile Lys 
1               5                   10              


<210>  54
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  54

Leu Ser Asp Leu Gln Pro Gln Ile Glu Arg 
1               5                   10  


<210>  55
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  55

Ile Gln Ser Ile Ala Leu Lys 
1               5           


<210>  56
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  56

Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val Ala Phe Thr Asn 
1               5                   10                  15      


His Phe Lys 
            


<210>  57
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  57

Gln Val Phe Ser Asp Val Gln Ala Arg 
1               5                   


<210>  58
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  58

Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg 
1               5                   10              


<210>  59
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  59

Tyr Gln Glu Thr Met Ser Ala Ile Arg 
1               5                   


<210>  60
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  60

Thr Trp Val Gln Gln Ser Glu Thr Lys 
1               5                   


<210>  61
<211>  17
<212>  PRT
<213>  Homo sapien

<400>  61

Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu Gln 
1               5                   10                  15      


Arg 
    


<210>  62
<211>  26
<212>  PRT
<213>  Homo sapien

<400>  62

Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln Gln Ser 
1               5                   10                  15      


Gly Leu Tyr Tyr Leu Ser Thr Thr Val Lys 
            20                  25      


<210>  63
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  63

Ala Pro Ser Glu Ile Ser Arg 
1               5           


<210>  64
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  64

Tyr Gln Ser Glu Phe Glu Glu Ile Glu Gly Arg 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  65

Leu Ser Ser Gln Leu Val Glu His Cys Gln Lys 
1               5                   10      


<210>  66
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  66

Leu Glu Glu Gln Met Asn Lys 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  67

Ile Gln Asn His Ile Gln Thr Leu Lys 
1               5                   


<210>  68
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  68

Trp Met Ala Glu Val Asp Val Phe Leu Lys 
1               5                   10  


<210>  69
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  69

Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile Leu Lys 
1               5                   10              


<210>  70
<211>  22
<212>  PRT
<213>  Homo sapien

<400>  70

Leu Leu Val Ser Asp Ile Gln Thr Ile Gln Pro Ser Leu Asn Ser Val 
1               5                   10                  15      


Asn Glu Gly Gly Gln Lys 
            20          


<210>  71
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  71

Asn Glu Ala Glu Pro Glu Phe Ala Ser Arg 
1               5                   10  


<210>  72
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  72

Leu Glu Thr Glu Leu Lys 
1               5       


<210>  73
<211>  16
<212>  PRT
<213>  Homo sapien

<400>  73

Glu Leu Asn Thr Gln Trp Asp His Met Cys Gln Gln Val Tyr Ala Arg 
1               5                   10                  15      


<210>  74
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  74

Thr Val Ser Leu Gln Lys 
1               5       


<210>  75
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  75

Asp Leu Ser Glu Met His Glu Trp Met Thr Gln Ala Glu Glu Glu Tyr 
1               5                   10                  15      


Leu Glu Arg 
            


<210>  76
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  76

Thr Pro Asp Glu Leu Gln Lys 
1               5           


<210>  77
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  77

Ala Val Glu Glu Met Lys 
1               5       


<210>  78
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  78

Glu Glu Ala Gln Gln Lys 
1               5       


<210>  79
<211>  22
<212>  PRT
<213>  Homo sapien

<400>  79

Leu Leu Thr Glu Ser Val Asn Ser Val Ile Ala Gln Ala Pro Pro Val 
1               5                   10                  15      


Ala Gln Glu Ala Leu Lys 
            20          


<210>  80
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  80

Glu Leu Glu Thr Leu Thr Thr Asn Tyr Gln Trp Leu Cys Thr Arg 
1               5                   10                  15  


<210>  81
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  81

Thr Leu Glu Glu Val Trp Ala Cys Trp His Glu Leu Leu Ser Tyr Leu 
1               5                   10                  15      


Glu Lys 
        


<210>  82
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  82

Trp Leu Asn Glu Val Glu Phe Lys 
1               5               


<210>  83
<211>  24
<212>  PRT
<213>  Homo sapien

<400>  83

Thr Thr Glu Asn Ile Pro Gly Gly Ala Glu Glu Ile Ser Glu Val Leu 
1               5                   10                  15      


Asp Ser Leu Glu Asn Leu Met Arg 
            20                  


<210>  84
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  84

His Ser Glu Asp Asn Pro Asn Gln Ile Arg 
1               5                   10  


<210>  85
<211>  26
<212>  PRT
<213>  Homo sapien

<400>  85

Ile Leu Ala Gln Thr Leu Thr Asp Gly Gly Val Met Asp Glu Leu Ile 
1               5                   10                  15      


Asn Glu Glu Leu Glu Thr Phe Asn Ser Arg 
            20                  25      


<210>  86
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  86

Glu Leu His Glu Glu Ala Val Arg 
1               5               


<210>  87
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  87

Leu Leu Glu Gln Ser Ile Gln Ser Ala Gln Glu Thr Glu Lys 
1               5                   10                  


<210>  88
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  88

Ser Leu His Leu Ile Gln Glu Ser Leu Thr Phe Ile Asp Lys 
1               5                   10                  


<210>  89
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  89

Gln Leu Ala Ala Tyr Ile Ala Asp Lys 
1               5                   


<210>  90
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  90

Val Asp Ala Ala Gln Met Pro Gln Glu Ala Gln Lys 
1               5                   10          


<210>  91
<211>  16
<212>  PRT
<213>  Homo sapien

<400>  91

Ile Gln Ser Asp Leu Thr Ser His Glu Ile Ser Leu Glu Glu Met Lys 
1               5                   10                  15      


<210>  92
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  92

Val Leu Ser Gln Ile Asp Val Ala Gln Lys 
1               5                   10  


<210>  93
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  93

Leu Gln Asp Val Ser Met Lys 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  94

Pro Ala Asn Phe Glu Gln Arg 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  95

Met Ile Leu Asp Glu Val Lys 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  96

Met His Leu Pro Ala Leu Glu Thr Lys 
1               5                   


<210>  97
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  97

Ser Val Glu Gln Glu Val Val Gln Ser Gln Leu Asn His Cys Val Asn 
1               5                   10                  15      


Leu Tyr Lys 
            


<210>  98
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  98

Ser Leu Ser Glu Val Lys 
1               5       


<210>  99
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  99

Ser Glu Val Glu Met Val Ile Lys 
1               5               


<210>  100
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  100

Gln Thr Glu Asn Pro Lys 
1               5       


<210>  101
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  101

Leu His Tyr Asn Glu Leu Gly Ala Lys 
1               5                   


<210>  102
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  102

Glu Met Asn Val Leu Thr Glu Trp Leu Ala Ala Thr Asp Met Glu Leu 
1               5                   10                  15      


Thr Lys 
        


<210>  103
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  103

Ser Ala Val Glu Gly Met Pro Ser Asn Leu Asp Ser Glu Val Ala Trp 
1               5                   10                  15      


Gly Lys 
        


<210>  104
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  104

Ser Ile Thr Glu Val Gly Glu Ala Leu Lys 
1               5                   10  


<210>  105
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  105

Glu Thr Leu Val Glu Asp Lys 
1               5           


<210>  106
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  106

Leu Ser Leu Leu Asn Ser Asn Trp Ile Ala Val Thr Ser Arg 
1               5                   10                  


<210>  107
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  107

Ala Glu Glu Trp Leu Asn Leu Leu Leu Glu Tyr Gln Lys 
1               5                   10              


<210>  108
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  108

His Met Glu Thr Phe Asp Gln Asn Val Asp His Ile Thr Lys 
1               5                   10                  


<210>  109
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  109

Trp Ile Ile Gln Ala Asp Thr Leu Leu Asp Glu Ser Glu Lys 
1               5                   10                  


<210>  110
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  110

Asp Gln Ala Ala Asn Leu Met Ala Asn Arg 
1               5                   10  


<210>  111
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  111

Leu Val Glu Pro Gln Ile Ser Glu Leu Asn His Arg 
1               5                   10          


<210>  112
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  112

Phe Ala Ala Ile Ser His Arg 
1               5           


<210>  113
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  113

Ala Ser Ile Pro Leu Lys 
1               5       


<210>  114
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  114

Glu Leu Glu Gln Phe Asn Ser Asp Ile Gln Lys 
1               5                   10      


<210>  115
<211>  16
<212>  PRT
<213>  Homo sapien

<400>  115

Leu Leu Glu Pro Leu Glu Ala Glu Ile Gln Gln Gly Val Asn Leu Lys 
1               5                   10                  15      


<210>  116
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  116

Glu Glu Asp Phe Asn Lys 
1               5       


<210>  117
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  117

Asp Met Asn Glu Asp Asn Glu Gly Thr Val Lys 
1               5                   10      


<210>  118
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  118

Gly Asp Asn Leu Gln Gln Arg 
1               5           


<210>  119
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  119

Gln Gln Leu Leu Gln Thr Lys 
1               5           


<210>  120
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  120

Ala Leu Glu Ile Ser His Gln Trp Tyr Gln Tyr Lys 
1               5                   10          


<210>  121
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  121

Gln Ala Asp Asp Leu Leu Lys 
1               5           


<210>  122
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  122

Cys Leu Asp Asp Ile Glu Lys 
1               5           


<210>  123
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  123

Leu Ala Ser Leu Pro Glu Pro Arg 
1               5               


<210>  124
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  124

Glu Glu Leu Asn Ala Val Arg 
1               5           


<210>  125
<211>  23
<212>  PRT
<213>  Homo sapien

<400>  125

Gln Ala Glu Gly Leu Ser Glu Asp Gly Ala Ala Met Ala Val Glu Pro 
1               5                   10                  15      


Thr Gln Ile Gln Leu Ser Lys 
            20              


<210>  126
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  126

Leu Asn Phe Ala Gln Ile His Thr Val Arg 
1               5                   10  


<210>  127
<211>  48
<212>  PRT
<213>  Homo sapien

<400>  127

Glu Glu Thr Met Met Val Met Thr Glu Asp Met Pro Leu Glu Ile Ser 
1               5                   10                  15      


Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala 
            20                  25                  30          


Leu Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys 
        35                  40                  45              


<210>  128
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  128

Asp Phe Glu Asp Leu Phe Lys 
1               5           


<210>  129
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  129

Gln Glu Glu Ser Leu Lys 
1               5       


<210>  130
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  130

Asp Ser Leu Gln Gln Ser Ser Gly Arg 
1               5                   


<210>  131
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  131

Ile Asp Ile Ile His Ser Lys 
1               5           


<210>  132
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  132

Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
1               5                   10          


<210>  133
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  133

Leu Gln Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys 
1               5                   10                  


<210>  134
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  134

Phe His Tyr Asp Ile Lys 
1               5       


<210>  135
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  135

Ile Phe Asn Gln Trp Leu Thr Glu Ala Glu Gln Phe Leu Arg 
1               5                   10                  


<210>  136
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  136

Thr Gln Ile Pro Glu Asn Trp Glu His Ala Lys 
1               5                   10      


<210>  137
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  137

Glu Leu Gln Asp Gly Ile Gly Gln Arg 
1               5                   


<210>  138
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  138

Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln Gln Ser Ser Lys 
1               5                   10                  15  


<210>  139
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  139

Thr Asp Ala Ser Ile Leu Gln Glu Lys 
1               5                   


<210>  140
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  140

Leu Gly Ser Leu Asn Leu Arg 
1               5           


<210>  141
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  141

Trp Gln Glu Val Cys Lys 
1               5       


<210>  142
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  142

Asn Ile Leu Ser Glu Phe Gln Arg 
1               5               


<210>  143
<211>  24
<212>  PRT
<213>  Homo sapien

<400>  143

Asp Leu Asn Glu Phe Val Leu Trp Leu Glu Glu Ala Asp Asn Ile Ala 
1               5                   10                  15      


Ser Ile Pro Leu Glu Pro Gly Lys 
            20                  


<210>  144
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  144

Leu Leu Val Glu Glu Leu Pro Leu Arg 
1               5                   


<210>  145
<211>  22
<212>  PRT
<213>  Homo sapien

<400>  145

Gln Leu Asn Glu Thr Gly Gly Pro Val Leu Val Ser Ala Pro Ile Ser 
1               5                   10                  15      


Pro Glu Glu Gln Asp Lys 
            20          


<210>  146
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  146

Gln Thr Asn Leu Gln Trp Ile Lys 
1               5               


<210>  147
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  147

Gln Gly Glu Ile Glu Ala Gln Ile Lys 
1               5                   


<210>  148
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  148

Asp Leu Gly Gln Leu Glu Lys 
1               5           


<210>  149
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  149

Leu Glu Asp Leu Glu Glu Gln Leu Asn His Leu Leu Leu Trp Leu Ser 
1               5                   10                  15      


Pro Ile Arg 
            


<210>  150
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  150

Asn Gln Leu Glu Ile Tyr Asn Gln Pro Asn Gln Glu Gly Pro Phe Asp 
1               5                   10                  15      


Val Lys 
        


<210>  151
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  151

Glu Thr Glu Ile Ala Val Gln Ala Lys 
1               5                   


<210>  152
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  152

Gln Pro Asp Val Glu Glu Ile Leu Ser Lys 
1               5                   10  


<210>  153
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  153

Gly Gln His Leu Tyr Lys 
1               5       


<210>  154
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  154

Pro Ala Thr Gln Pro Val Lys 
1               5           


<210>  155
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  155

Leu Glu Asp Leu Ser Ser Glu Trp Lys 
1               5                   


<210>  156
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  156

Leu Leu Gln Glu Leu Arg 
1               5       


<210>  157
<211>  29
<212>  PRT
<213>  Homo sapien

<400>  157

Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr 
1               5                   10                  15      


Gln Thr Val Thr Leu Val Thr Gln Pro Val Val Thr Lys 
            20                  25                  


<210>  158
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  158

Glu Thr Ala Ile Ser Lys 
1               5       


<210>  159
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  159

Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Ala Leu Ala Asp 
1               5                   10                  15      


Phe Asn Arg 
            


<210>  160
<211>  17
<212>  PRT
<213>  Homo sapien

<400>  160

Ala Trp Thr Glu Leu Thr Asp Trp Leu Ser Leu Leu Asp Gln Val Ile 
1               5                   10                  15      


Lys 
    


<210>  161
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  161

Val Met Val Gly Asp Leu Glu Asp Ile Asn Glu Met Ile Ile Lys 
1               5                   10                  15  


<210>  162
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  162

Ala Thr Met Gln Asp Leu Glu Gln Arg 
1               5                   


<210>  163
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  163

Pro Gln Leu Glu Glu Leu Ile Thr Ala Ala Gln Asn Leu Lys 
1               5                   10                  


<210>  164
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  164

Thr Ser Asn Gln Glu Ala Arg 
1               5           


<210>  165
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  165

Thr Ile Ile Thr Asp Arg 
1               5       


<210>  166
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  166

Ile Gln Asn Gln Trp Asp Glu Val Gln Glu His Leu Gln Asn Arg 
1               5                   10                  15  


<210>  167
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  167

Gln Gln Leu Asn Glu Met Leu Lys 
1               5               


<210>  168
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  168

Asp Ser Thr Gln Trp Leu Glu Ala Lys 
1               5                   


<210>  169
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  169

Glu Glu Ala Glu Gln Val Leu Gly Gln Ala Arg 
1               5                   10      


<210>  170
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  170

Glu Gly Pro Tyr Thr Val Asp Ala Ile Gln Lys 
1               5                   10      


<210>  171
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  171

Gln Trp Gln Thr Asn Val Asp Val Ala Asn Asp Leu Ala Leu Lys 
1               5                   10                  15  


<210>  172
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  172

Asp Tyr Ser Ala Asp Asp Thr Arg 
1               5               


<210>  173
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  173

Val His Met Ile Thr Glu Asn Ile Asn Ala Ser Trp Arg 
1               5                   10              


<210>  174
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  174

Glu Ala Ala Leu Glu Glu Thr His Arg 
1               5                   


<210>  175
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  175

Leu Leu Gln Gln Phe Pro Leu Asp Leu Glu Lys 
1               5                   10      


<210>  176
<211>  20
<212>  PRT
<213>  Homo sapien

<400>  176

Phe Leu Ala Trp Leu Thr Glu Ala Glu Thr Thr Ala Asn Val Leu Gln 
1               5                   10                  15      


Asp Ala Thr Arg 
            20  


<210>  177
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  177

Leu Leu Glu Asp Ser Lys 
1               5       


<210>  178
<211>  25
<212>  PRT
<213>  Homo sapien

<400>  178

Gln Trp Gln Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr 
1               5                   10                  15      


His Asn Leu Asp Glu Asn Ser Gln Lys 
            20                  25  


<210>  179
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  179

Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln Arg 
1               5                   10              


<210>  180
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  180

Leu Asp Asn Met Asn Phe Lys 
1               5           


<210>  181
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  181

Ser His Leu Glu Ala Ser Ser Asp Gln Trp Lys 
1               5                   10      


<210>  182
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  182

Leu His Leu Ser Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys 
1               5                   10                  15  


<210>  183
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  183

Asp Asp Glu Leu Ser Arg 
1               5       


<210>  184
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  184

Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys 
1               5                   10              


<210>  185
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  185

Gln Asn Asp Val His Arg 
1               5       


<210>  186
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  186

Glu Pro Val Ile Met Ser Thr Leu Glu Thr Val Arg 
1               5                   10          


<210>  187
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  187

Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 
1               5                   10              


<210>  188
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  188

Leu Tyr Gln Glu Pro Arg 
1               5       


<210>  189
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  189

Glu Leu Pro Pro Glu Glu Arg 
1               5           


<210>  190
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  190

Ala Gln Asn Val Thr Arg 
1               5       


<210>  191
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  191

Gln Ala Glu Glu Val Asn Thr Glu Trp Glu Lys 
1               5                   10      


<210>  192
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  192

Leu Asn Leu His Ser Ala Asp Trp Gln Arg 
1               5                   10  


<210>  193
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  193

Ile Asp Glu Thr Leu Glu Arg 
1               5           


<210>  194
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  194

Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys 
1               5                   10                  


<210>  195
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  195

Gln Ala Glu Val Ile Lys 
1               5       


<210>  196
<211>  20
<212>  PRT
<213>  Homo sapien

<400>  196

Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 
1               5                   10                  15      


His Leu Glu Lys 
            20  


<210>  197
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  197

Gly Glu Ile Ala Pro Leu Lys 
1               5           


<210>  198
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  198

Glu Asn Val Ser His Val Asn Asp Leu Ala Arg 
1               5                   10      


<210>  199
<211>  23
<212>  PRT
<213>  Homo sapien

<400>  199

Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr 
1               5                   10                  15      


Leu Glu Asp Leu Asn Thr Arg 
            20              


<210>  200
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  200

Leu Leu Gln Val Ala Val Glu Asp Arg 
1               5                   


<210>  201
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  201

Gln Leu His Glu Ala His Arg 
1               5           


<210>  202
<211>  20
<212>  PRT
<213>  Homo sapien

<400>  202

Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 
1               5                   10                  15      


Pro Trp Glu Arg 
            20  


<210>  203
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  203

Ala Ile Ser Pro Asn Lys 
1               5       


<210>  204
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  204

Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His 
1               5                   10                  15      


Pro Lys 
        


<210>  205
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  205

Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val Arg 
1               5                   10                  15  


<210>  206
<211>  22
<212>  PRT
<213>  Homo sapien

<400>  206

Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu 
1               5                   10                  15      


Asp Gln His Asn Leu Lys 
            20          


<210>  207
<211>  21
<212>  PRT
<213>  Homo sapien

<400>  207

Gln Asn Asp Gln Pro Met Asp Ile Leu Gln Ile Ile Asn Cys Leu Thr 
1               5                   10                  15      


Thr Ile Tyr Asp Arg 
            20      


<210>  208
<211>  30
<212>  PRT
<213>  Homo sapien

<400>  208

Leu Glu Gln Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp 
1               5                   10                  15      


Met Cys Leu Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg 
            20                  25                  30  


<210>  209
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  209

Thr Gly Ile Ile Ser Leu Cys Lys 
1               5               


<210>  210
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  210

Ala His Leu Glu Asp Lys 
1               5       


<210>  211
<211>  12
<212>  PRT
<213>  Homo sapien

<400>  211

Gln Val Ala Ser Ser Thr Gly Phe Cys Asp Gln Arg 
1               5                   10          


<210>  212
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  212

Leu Gly Leu Leu Leu His Asp Ser Ile Gln Ile Pro Arg 
1               5                   10              


<210>  213
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  213

Gln Leu Gly Glu Val Ala Ser Phe Gly Gly Ser Asn Ile Glu Pro Ser 
1               5                   10                  15      


Val Arg 
        


<210>  214
<211>  13
<212>  PRT
<213>  Homo sapien

<400>  214

Pro Glu Ile Glu Ala Ala Leu Phe Leu Asp Trp Met Arg 
1               5                   10              


<210>  215
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  215

Leu Glu Pro Gln Ser Met Val Trp Leu Pro Val Leu His Arg 
1               5                   10                  


<210>  216
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  216

Val Ala Ala Ala Glu Thr Ala Lys 
1               5               


<210>  217
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  217

Glu Cys Pro Ile Ile Gly Phe Arg 
1               5               


<210>  218
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  218

His Phe Asn Tyr Asp Ile Cys Gln Ser Cys Phe Phe Ser Gly Arg 
1               5                   10                  15  


<210>  219
<211>  19
<212>  PRT
<213>  Homo sapien

<400>  219

Met His Tyr Pro Met Val Glu Tyr Cys Thr Pro Thr Thr Ser Gly Glu 
1               5                   10                  15      


Asp Val Arg 
            


<210>  220
<211>  45
<212>  PRT
<213>  Homo sapien

<400>  220

Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu 
1               5                   10                  15      


Thr Pro Val Thr Leu Ile Asn Phe Trp Pro Val Asp Ser Ala Pro Ala 
            20                  25                  30          


Ser Ser Pro Gln Leu Ser His Asp Asp Thr His Ser Arg 
        35                  40                  45  


<210>  221
<211>  7
<212>  PRT
<213>  Homo sapien

<400>  221

Ile Glu His Tyr Ala Ser Arg 
1               5           


<210>  222
<211>  46
<212>  PRT
<213>  Homo sapien

<400>  222

Leu Ala Glu Met Glu Asn Ser Asn Gly Ser Tyr Leu Asn Asp Ser Ile 
1               5                   10                  15      


Ser Pro Asn Glu Ser Ile Asp Asp Glu His Leu Leu Ile Gln His Tyr 
            20                  25                  30          


Cys Gln Ser Leu Asn Gln Asp Ser Pro Leu Ser Gln Pro Arg 
        35                  40                  45      


<210>  223
<211>  14
<212>  PRT
<213>  Homo sapien

<400>  223

Ser Pro Ala Gln Ile Leu Ile Ser Leu Glu Ser Glu Glu Arg 
1               5                   10                  


<210>  224
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  224

Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg 
1               5                   10  


<210>  225
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  225

Asn Leu Gln Ala Glu Tyr Asp Arg 
1               5               


<210>  226
<211>  6
<212>  PRT
<213>  Homo sapien

<400>  226

Gln Gln His Glu His Lys 
1               5       


<210>  227
<211>  20
<212>  PRT
<213>  Homo sapien

<400>  227

Gly Leu Ser Pro Leu Pro Ser Pro Pro Glu Met Met Pro Thr Ser Pro 
1               5                   10                  15      


Gln Ser Pro Arg 
            20  


<210>  228
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  228

Asp Ala Glu Leu Ile Ala Glu Ala Lys 
1               5                   


<210>  229
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  229

Met Gln Ile Leu Glu Asp His Asn Lys 
1               5                   


<210>  230
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  230

Gln Leu Glu Ser Gln Leu His Arg 
1               5               


<210>  231
<211>  11
<212>  PRT
<213>  Homo sapien

<400>  231

Gln Leu Leu Glu Gln Pro Gln Ala Glu Ala Lys 
1               5                   10      


<210>  232
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  232

Val Asn Gly Thr Thr Val Ser Ser Pro Ser Thr Ser Leu Gln Arg 
1               5                   10                  15  


<210>  233
<211>  10
<212>  PRT
<213>  Homo sapien

<400>  233

Ser Asp Ser Ser Gln Pro Met Leu Leu Arg 
1               5                   10  


<210>  234
<211>  41
<212>  PRT
<213>  Homo sapien

<400>  234

Val Val Gly Ser Gln Thr Ser Asp Ser Met Gly Glu Glu Asp Leu Leu 
1               5                   10                  15      


Ser Pro Pro Gln Asp Thr Ser Thr Gly Leu Glu Glu Val Met Glu Gln 
            20                  25                  30          


Leu Asn Asn Ser Phe Pro Ser Ser Arg 
        35                  40      


<210>  235
<211>  35
<212>  PRT
<213>  Homo sapien

<400>  235

Trp Val Leu Leu Gln Asp Gln Pro Asp Leu Ala Pro Gly Leu Thr Thr 
1               5                   10                  15      


Ile Gly Ala Ser Pro Thr Gln Thr Val Thr Leu Val Thr Gln Pro Val 
            20                  25                  30          


Val Thr Lys 
        35  


<210>  236
<211>  15
<212>  PRT
<213>  Homo sapien

<400>  236

Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr His Arg 
1               5                   10                  15  


<210>  237
<211>  17
<212>  PRT
<213>  Homo sapien

<400>  237

Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu 
1               5                   10                  15      


Thr 
    


<210>  238
<211>  38
<212>  PRT
<213>  Homo sapien

<400>  238

Gln Ser Asn Leu His Ser Tyr Val Pro Ser Thr Tyr Leu Thr Glu Ile 
1               5                   10                  15      


Thr His Val Ser Gln Ala Leu Leu Glu Val Glu Gln Leu Leu Asn Ala 
            20                  25                  30          


Pro Asp Leu Cys Ala Lys 
        35              


<210>  239
<211>  9
<212>  PRT
<213>  Homo sapien

<400>  239

Leu Glu Glu Gln Ser Asp Gln Trp Lys 
1               5                   


<210>  240
<211>  20
<212>  PRT
<213>  Homo sapien

<400>  240

Met Gly Tyr Leu Pro Val Gln Thr Val Leu Glu Gly Asp Asn Met Glu 
1               5                   10                  15      


Thr Asp Thr Met 
            20  


<210>  241
<211>  8
<212>  PRT
<213>  Homo sapien

<400>  241

Leu Gln Glu Leu Thr Leu Glu Arg 
1               5               


<210>  242
<211>  3685
<212>  PRT
<213>  Homo sapien

<400>  242

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Lys Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  243
<211>  1325
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant protein

<400>  243

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Gln Pro Asp Leu 
545                 550                 555                 560 


Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr 
                565                 570                 575     


Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu 
            580                 585                 590         


Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr His Arg Leu Leu 
        595                 600                 605             


Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu 
    610                 615                 620                 


Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg 
625                 630                 635                 640 


Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln 
                645                 650                 655     


Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu 
            660                 665                 670         


Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp 
        675                 680                 685             


Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser 
    690                 695                 700                 


Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser 
705                 710                 715                 720 


Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val 
                725                 730                 735     


Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly 
            740                 745                 750         


Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe 
        755                 760                 765             


Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu 
    770                 775                 780                 


Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 
785                 790                 795                 800 


Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn 
                805                 810                 815     


Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp 
            820                 825                 830         


Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu 
        835                 840                 845             


Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp 
    850                 855                 860                 


Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val 
865                 870                 875                 880 


Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys 
                885                 890                 895     


Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val 
            900                 905                 910         


Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 
        915                 920                 925             


Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu 
    930                 935                 940                 


Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg 
945                 950                 955                 960 


Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 
                965                 970                 975     


Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn 
            980                 985                 990         


His Glu Thr Gln Thr Thr Cys Trp  Asp His Pro Lys Met  Thr Glu Leu 
        995                 1000                 1005             


Tyr Gln  Ser Leu Ala Asp Leu  Asn Asn Val Arg Phe  Ser Ala Tyr 
    1010                 1015                 1020             


Arg Thr  Ala Met Lys Leu Arg  Arg Leu Gln Lys Ala  Leu Cys Leu 
    1025                 1030                 1035             


Asp Leu  Leu Ser Leu Ser Ala  Ala Cys Asp Ala Leu  Asp Gln His 
    1040                 1045                 1050             


Asn Leu  Lys Gln Asn Asp Gln  Pro Met Asp Ile Leu  Gln Ile Ile 
    1055                 1060                 1065             


Asn Cys  Leu Thr Thr Ile Tyr  Asp Arg Leu Glu Gln  Glu His Asn 
    1070                 1075                 1080             


Asn Leu  Val Asn Val Pro Leu  Cys Val Asp Met Cys  Leu Asn Trp 
    1085                 1090                 1095             


Leu Leu  Asn Val Tyr Asp Thr  Gly Arg Thr Gly Arg  Ile Arg Val 
    1100                 1105                 1110             


Leu Ser  Phe Lys Thr Gly Ile  Ile Ser Leu Cys Lys  Ala His Leu 
    1115                 1120                 1125             


Glu Asp  Lys Tyr Arg Tyr Leu  Phe Lys Gln Val Ala  Ser Ser Thr 
    1130                 1135                 1140             


Gly Phe  Cys Asp Gln Arg Arg  Leu Gly Leu Leu Leu  His Asp Ser 
    1145                 1150                 1155             


Ile Gln  Ile Pro Arg Gln Leu  Gly Glu Val Ala Ser  Phe Gly Gly 
    1160                 1165                 1170             


Ser Asn  Ile Glu Pro Ser Val  Arg Ser Cys Phe Gln  Phe Ala Asn 
    1175                 1180                 1185             


Asn Lys  Pro Glu Ile Glu Ala  Ala Leu Phe Leu Asp  Trp Met Arg 
    1190                 1195                 1200             


Leu Glu  Pro Gln Ser Met Val  Trp Leu Pro Val Leu  His Arg Val 
    1205                 1210                 1215             


Ala Ala  Ala Glu Thr Ala Lys  His Gln Ala Lys Cys  Asn Ile Cys 
    1220                 1225                 1230             


Lys Glu  Cys Pro Ile Ile Gly  Phe Arg Tyr Arg Ser  Leu Lys His 
    1235                 1240                 1245             


Phe Asn  Tyr Asp Ile Cys Gln  Ser Cys Phe Phe Ser  Gly Arg Val 
    1250                 1255                 1260             


Ala Lys  Gly His Lys Met His  Tyr Pro Met Val Glu  Tyr Cys Thr 
    1265                 1270                 1275             


Pro Thr  Thr Ser Gly Glu Asp  Val Arg Asp Phe Ala  Lys Val Leu 
    1280                 1285                 1290             


Lys Asn  Lys Phe Arg Thr Lys  Arg Tyr Phe Ala Lys  His Pro Arg 
    1295                 1300                 1305             


Met Gly  Tyr Leu Pro Val Gln  Thr Val Leu Glu Gly  Asp Asn Met 
    1310                 1315                 1320             


Glu Thr  
    1325 


<210>  244
<211>  1192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant protein

<400>  244

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Thr Leu Glu Arg Leu Gln Glu Leu 
705                 710                 715                 720 


Gln Glu Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val 
                725                 730                 735     


Ile Lys Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu 
            740                 745                 750         


Gln Asp His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro 
        755                 760                 765             


Leu Lys Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr 
    770                 775                 780                 


Thr Leu Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp 
785                 790                 795                 800 


Leu Asn Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val 
                805                 810                 815     


Arg Gln Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His 
            820                 825                 830         


Phe Leu Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro 
        835                 840                 845             


Asn Lys Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp 
    850                 855                 860                 


Asp His Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn 
865                 870                 875                 880 


Asn Val Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu 
                885                 890                 895     


Gln Lys Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp 
            900                 905                 910         


Ala Leu Asp Gln His Asn Leu Lys Gln Asn Asp Gln Pro Met Asp Ile 
        915                 920                 925             


Leu Gln Ile Ile Asn Cys Leu Thr Thr Ile Tyr Asp Arg Leu Glu Gln 
    930                 935                 940                 


Glu His Asn Asn Leu Val Asn Val Pro Leu Cys Val Asp Met Cys Leu 
945                 950                 955                 960 


Asn Trp Leu Leu Asn Val Tyr Asp Thr Gly Arg Thr Gly Arg Ile Arg 
                965                 970                 975     


Val Leu Ser Phe Lys Thr Gly Ile Ile Ser Leu Cys Lys Ala His Leu 
            980                 985                 990         


Glu Asp Lys Tyr Arg Tyr Leu Phe  Lys Gln Val Ala Ser  Ser Thr Gly 
        995                 1000                 1005             


Phe Cys  Asp Gln Arg Arg Leu  Gly Leu Leu Leu His  Asp Ser Ile 
    1010                 1015                 1020             


Gln Ile  Pro Arg Gln Leu Gly  Glu Val Ala Ser Phe  Gly Gly Ser 
    1025                 1030                 1035             


Asn Ile  Glu Pro Ser Val Arg  Ser Cys Phe Gln Phe  Ala Asn Asn 
    1040                 1045                 1050             


Lys Pro  Glu Ile Glu Ala Ala  Leu Phe Leu Asp Trp  Met Arg Leu 
    1055                 1060                 1065             


Glu Pro  Gln Ser Met Val Trp  Leu Pro Val Leu His  Arg Val Ala 
    1070                 1075                 1080             


Ala Ala  Glu Thr Ala Lys His  Gln Ala Lys Cys Asn  Ile Cys Lys 
    1085                 1090                 1095             


Glu Cys  Pro Ile Ile Gly Phe  Arg Tyr Arg Ser Leu  Lys His Phe 
    1100                 1105                 1110             


Asn Tyr  Asp Ile Cys Gln Ser  Cys Phe Phe Ser Gly  Arg Val Ala 
    1115                 1120                 1125             


Lys Gly  His Lys Met His Tyr  Pro Met Val Glu Tyr  Cys Thr Pro 
    1130                 1135                 1140             


Thr Thr  Ser Gly Glu Asp Val  Arg Asp Phe Ala Lys  Val Leu Lys 
    1145                 1150                 1155             


Asn Lys  Phe Arg Thr Lys Arg  Tyr Phe Ala Lys His  Pro Arg Met 
    1160                 1165                 1170             


Gly Tyr  Leu Pro Val Gln Thr  Val Leu Glu Gly Asp  Asn Met Glu 
    1175                 1180                 1185             


Thr Asp  Thr Met 
    1190         


<210>  245
<211>  1270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  recombinant protein

<400>  245

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Ser Tyr 
        435                 440                 445             


Val Pro Ser Thr Tyr Leu Thr Glu Ile Thr His Val Ser Gln Ala Leu 
    450                 455                 460                 


Leu Glu Val Glu Gln Leu Leu Asn Ala Pro Asp Leu Cys Ala Lys Asp 
465                 470                 475                 480 


Phe Glu Asp Leu Phe Lys Gln Glu Glu Ser Leu Lys Asn Ile Lys Asp 
                485                 490                 495     


Ser Leu Gln Gln Ser Ser Gly Arg Ile Asp Ile Ile His Ser Lys Lys 
            500                 505                 510         


Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg Val Lys Leu Gln 
        515                 520                 525             


Glu Ala Leu Ser Gln Leu Asp Phe Gln Trp Glu Lys Val Asn Lys Met 
    530                 535                 540                 


Tyr Lys Asp Arg Gln Gly Arg Phe Asp Arg Ser Val Glu Lys Trp Arg 
545                 550                 555                 560 


Arg Phe His Tyr Asp Ile Lys Ile Phe Asn Gln Trp Leu Thr Glu Ala 
                565                 570                 575     


Glu Gln Phe Leu Arg Lys Thr Gln Ile Pro Glu Asn Trp Glu His Ala 
            580                 585                 590         


Lys Tyr Lys Trp Tyr Leu Lys Glu Leu Gln Asp Gly Ile Gly Gln Arg 
        595                 600                 605             


Gln Thr Val Val Arg Thr Leu Asn Ala Thr Gly Glu Glu Ile Ile Gln 
    610                 615                 620                 


Gln Ser Ser Lys Thr Asp Ala Ser Ile Leu Gln Glu Lys Leu Gly Ser 
625                 630                 635                 640 


Leu Asn Leu Arg Trp Gln Glu Val Cys Lys Gln Leu Ser Asp Arg Lys 
                645                 650                 655     


Lys Arg Leu Glu Glu Gln Ser Asp Gln Trp Lys Arg Leu His Leu Ser 
            660                 665                 670         


Leu Gln Glu Leu Leu Val Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser 
        675                 680                 685             


Arg Gln Ala Pro Ile Gly Gly Asp Phe Pro Ala Val Gln Lys Gln Asn 
    690                 695                 700                 


Asp Val His Arg Ala Phe Lys Arg Glu Leu Lys Thr Lys Glu Pro Val 
705                 710                 715                 720 


Ile Met Ser Thr Leu Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro 
                725                 730                 735     


Leu Glu Gly Leu Glu Lys Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro 
            740                 745                 750         


Glu Glu Arg Ala Gln Asn Val Thr Arg Leu Leu Arg Lys Gln Ala Glu 
        755                 760                 765             


Glu Val Asn Thr Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp 
    770                 775                 780                 


Gln Arg Lys Ile Asp Glu Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu 
785                 790                 795                 800 


Ala Thr Asp Glu Leu Asp Leu Lys Leu Arg Gln Ala Glu Val Ile Lys 
                805                 810                 815     


Gly Ser Trp Gln Pro Val Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp 
            820                 825                 830         


His Leu Glu Lys Val Lys Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys 
        835                 840                 845             


Glu Asn Val Ser His Val Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu 
    850                 855                 860                 


Gly Ile Gln Leu Ser Pro Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn 
865                 870                 875                 880 


Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln 
                885                 890                 895     


Leu His Glu Ala His Arg Asp Phe Gly Pro Ala Ser Gln His Phe Leu 
            900                 905                 910         


Ser Thr Ser Val Gln Gly Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys 
        915                 920                 925             


Val Pro Tyr Tyr Ile Asn His Glu Thr Gln Thr Thr Cys Trp Asp His 
    930                 935                 940                 


Pro Lys Met Thr Glu Leu Tyr Gln Ser Leu Ala Asp Leu Asn Asn Val 
945                 950                 955                 960 


Arg Phe Ser Ala Tyr Arg Thr Ala Met Lys Leu Arg Arg Leu Gln Lys 
                965                 970                 975     


Ala Leu Cys Leu Asp Leu Leu Ser Leu Ser Ala Ala Cys Asp Ala Leu 
            980                 985                 990         


Asp Gln His Asn Leu Lys Gln Asn  Asp Gln Pro Met Asp  Ile Leu Gln 
        995                 1000                 1005             


Ile Ile  Asn Cys Leu Thr Thr  Ile Tyr Asp Arg Leu  Glu Gln Glu 
    1010                 1015                 1020             


His Asn  Asn Leu Val Asn Val  Pro Leu Cys Val Asp  Met Cys Leu 
    1025                 1030                 1035             


Asn Trp  Leu Leu Asn Val Tyr  Asp Thr Gly Arg Thr  Gly Arg Ile 
    1040                 1045                 1050             


Arg Val  Leu Ser Phe Lys Thr  Gly Ile Ile Ser Leu  Cys Lys Ala 
    1055                 1060                 1065             


His Leu  Glu Asp Lys Tyr Arg  Tyr Leu Phe Lys Gln  Val Ala Ser 
    1070                 1075                 1080             


Ser Thr  Gly Phe Cys Asp Gln  Arg Arg Leu Gly Leu  Leu Leu His 
    1085                 1090                 1095             


Asp Ser  Ile Gln Ile Pro Arg  Gln Leu Gly Glu Val  Ala Ser Phe 
    1100                 1105                 1110             


Gly Gly  Ser Asn Ile Glu Pro  Ser Val Arg Ser Cys  Phe Gln Phe 
    1115                 1120                 1125             


Ala Asn  Asn Lys Pro Glu Ile  Glu Ala Ala Leu Phe  Leu Asp Trp 
    1130                 1135                 1140             


Met Arg  Leu Glu Pro Gln Ser  Met Val Trp Leu Pro  Val Leu His 
    1145                 1150                 1155             


Arg Val  Ala Ala Ala Glu Thr  Ala Lys His Gln Ala  Lys Cys Asn 
    1160                 1165                 1170             


Ile Cys  Lys Glu Cys Pro Ile  Ile Gly Phe Arg Tyr  Arg Ser Leu 
    1175                 1180                 1185             


Lys His  Phe Asn Tyr Asp Ile  Cys Gln Ser Cys Phe  Phe Ser Gly 
    1190                 1195                 1200             


Arg Val  Ala Lys Gly His Lys  Met His Tyr Pro Met  Val Glu Tyr 
    1205                 1210                 1215             


Cys Thr  Pro Thr Thr Ser Gly  Glu Asp Val Arg Asp  Phe Ala Lys 
    1220                 1225                 1230             


Val Leu  Lys Asn Lys Phe Arg  Thr Lys Arg Tyr Phe  Ala Lys His 
    1235                 1240                 1245             


Pro Arg  Met Gly Tyr Leu Pro  Val Gln Thr Val Leu  Glu Gly Asp 
    1250                 1255                 1260             


Asn Met  Glu Thr Asp Thr Met  
    1265                 1270 


<210>  246
<211>  23
<212>  PRT
<213>  Homo sapien

<400>  246

Ala Ile Ser Lys Leu Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro 
1               5                   10                  15      


Thr His Arg Leu Leu Gln Gln 
            20              


<210>  247
<211>  21
<212>  PRT
<213>  Homo sapien

<400>  247

Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr Ala Ile 
1               5                   10                  15      


Lys Ser Gln Leu Lys 
            20      


<210>  248
<211>  21
<212>  PRT
<213>  Homo sapien

<400>  248

His Ser Lys Lys Thr Ala Ala Leu Gln Ser Ala Thr Pro Val Glu Arg 
1               5                   10                  15      


Val Lys Leu Gln Glu 
            20      


<210>  249
<211>  21
<212>  PRT
<213>  Homo sapien

<400>  249

Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp Ala Val Leu Leu Gln 
1               5                   10                  15      


Arg Arg Leu Asp Asn 
            20      


<210>  250
<211>  21
<212>  PRT
<213>  Homo sapien

<400>  250

Glu Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu 
1               5                   10                  15      


Lys Leu Tyr Gln Glu 
            20      


<210>  251
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  251

Glu Trp Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile 
1               5                   10                  15      


Asp Glu 
        


<210>  252
<211>  17
<212>  PRT
<213>  Homo sapien

<400>  252

Thr Arg Trp Lys Leu Leu Gln Val Ala Val Glu Asp Arg Val Arg Gln 
1               5                   10                  15      


Leu 
    


<210>  253
<211>  18
<212>  PRT
<213>  Homo sapien

<400>  253

Glu Leu Glu Arg Ile Leu Ala Asp Leu Glu Glu Glu Asn Arg Asn Leu 
1               5                   10                  15      


Gln Ala 
        


