<110>    SK bioscience Co., Ltd.

<120>    Vaccine composition for preventing or treating infection of
         SARS-CoV-2

<130>    PCT21-306

<150>    KR 10-2020-0141598
<151>    2020-10-28

<160>    28

<170>    KoPatentIn 3.0

<210>    1
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Tetanus toxoid P2 epitope  peptide


<400>    1
Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu
  1               5                  10                  15


<210>    2
<211>    673
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    the fragment from 14 to 686 amino acids of S protein of
         Sars-cov-2


<400>    2
Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr
  1               5                  10                  15 

Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser
             20                  25                  30 

Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn
         35                  40                  45 

Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys
     50                  55                  60 

Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala
 65                  70                  75                  80 

Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr
                 85                  90                  95 

Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn
            100                 105                 110 

Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu
        115                 120                 125 

Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe
    130                 135                 140 

Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln
145                 150                 155                 160 

Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu
                165                 170                 175 

Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser
            180                 185                 190 

Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser
        195                 200                 205 

Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg
    210                 215                 220 

Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp
225                 230                 235                 240 

Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr
                245                 250                 255 

Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile
            260                 265                 270 

Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys
        275                 280                 285 

Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn
    290                 295                 300 

Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr
305                 310                 315                 320 

Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser
                325                 330                 335 

Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr
            340                 345                 350 

Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly
        355                 360                 365 

Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala
    370                 375                 380 

Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly
385                 390                 395                 400 

Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe
                405                 410                 415 

Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val
            420                 425                 430 

Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu
        435                 440                 445 

Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser
    450                 455                 460 

Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln
465                 470                 475                 480 

Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg
                485                 490                 495 

Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys
            500                 505                 510 

Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe
        515                 520                 525 

Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys
    530                 535                 540 

Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr
545                 550                 555                 560 

Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro
                565                 570                 575 

Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser
            580                 585                 590 

Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro
        595                 600                 605 

Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser
    610                 615                 620 

Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala
625                 630                 635                 640 

Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly
                645                 650                 655 

Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg
            660                 665                 670 

Ser
   


<210>    3
<211>    269
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    the fragment from 323 to 591 amino acids of S protein of
         Sars-cov-2


<400>    3
Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe
  1               5                  10                  15 

Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn
             20                  25                  30 

Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn
         35                  40                  45 

Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys
     50                  55                  60 

Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile
 65                  70                  75                  80 

Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile
                 85                  90                  95 

Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile
            100                 105                 110 

Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn
        115                 120                 125 

Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg
    130                 135                 140 

Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly
145                 150                 155                 160 

Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln
                165                 170                 175 

Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser
            180                 185                 190 

Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser
        195                 200                 205 

Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu
    210                 215                 220 

Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe
225                 230                 235                 240 

Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp
                245                 250                 255 

Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser
            260                 265                


<210>    4
<211>    217
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    the fragment from 321 to 537 amino acids of S protein of
         Sars-cov-2


<400>    4
Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys
  1               5                  10                  15 

Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala
             20                  25                  30 

Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu
         35                  40                  45 

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro
     50                  55                  60 

Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe
 65                  70                  75                  80 

Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly
                 85                  90                  95 

Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys
            100                 105                 110 

Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn
        115                 120                 125 

Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe
    130                 135                 140 

Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys
145                 150                 155                 160 

Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly
                165                 170                 175 

Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val
            180                 185                 190 

Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys
        195                 200                 205 

Lys Ser Thr Asn Leu Val Lys Asn Lys
    210                 215        


<210>    5
<211>    181
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    the fragment from 336 to 516 amino acids of S protein of
         Sars-cov-2


<400>    5
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr
  1               5                  10                  15 

Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val
             20                  25                  30 

Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser
         35                  40                  45 

Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser
     50                  55                  60 

Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr
 65                  70                  75                  80 

Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly
                 85                  90                  95 

Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly
            100                 105                 110 

Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro
        115                 120                 125 

Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro
    130                 135                 140 

Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr
145                 150                 155                 160 

Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val
                165                 170                 175 

Val Leu Ser Phe Glu
            180    


<210>    6
<211>    694
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SK-E-S1-P2


<400>    6
Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu
  1               5                  10                  15 

Gly Ser Gly Ser Gly Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu
             20                  25                  30 

Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp
         35                  40                  45 

Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu
     50                  55                  60 

Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly
 65                  70                  75                  80 

Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp
                 85                  90                  95 

Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp
            100                 105                 110 

Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val
        115                 120                 125 

Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys
    130                 135                 140 

Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp
145                 150                 155                 160 

Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe
                165                 170                 175 

Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly
            180                 185                 190 

Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr
        195                 200                 205 

Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu
    210                 215                 220 

Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly
225                 230                 235                 240 

Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr
                245                 250                 255 

Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala
            260                 265                 270 

Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn
        275                 280                 285 

Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu
    290                 295                 300 

Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile
305                 310                 315                 320 

Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg
                325                 330                 335 

Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala
            340                 345                 350 

Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn
        355                 360                 365 

Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr
    370                 375                 380 

Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe
385                 390                 395                 400 

Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg
                405                 410                 415 

Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys
            420                 425                 430 

Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn
        435                 440                 445 

Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe
    450                 455                 460 

Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile
465                 470                 475                 480 

Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys
                485                 490                 495 

Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly
            500                 505                 510 

Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala
        515                 520                 525 

Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn
    530                 535                 540 

Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu
545                 550                 555                 560 

Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp
                565                 570                 575 

Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile
            580                 585                 590 

Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro
        595                 600                 605 

Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn
    610                 615                 620 

Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr
625                 630                 635                 640 

Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly
                645                 650                 655 

Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile
            660                 665                 670 

Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser
        675                 680                 685 

Pro Arg Arg Ala Arg Ser
    690                


<210>    7
<211>    290
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SK-E-S1-T1-P2


<400>    7
Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu
  1               5                  10                  15 

Gly Ser Gly Ser Gly Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr
             20                  25                  30 

Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser
         35                  40                  45 

Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr
     50                  55                  60 

Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly
 65                  70                  75                  80 

Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala
                 85                  90                  95 

Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly
            100                 105                 110 

Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe
        115                 120                 125 

Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val
    130                 135                 140 

Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu
145                 150                 155                 160 

Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser
                165                 170                 175 

Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln
            180                 185                 190 

Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg
        195                 200                 205 

Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys
    210                 215                 220 

Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe
225                 230                 235                 240 

Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys
                245                 250                 255 

Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr
            260                 265                 270 

Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro
        275                 280                 285 

Cys Ser
    290


<210>    8
<211>    238
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SK-E-RBD-Ex3-P2


<400>    8
Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu
  1               5                  10                  15 

Gly Ser Gly Ser Gly Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn
             20                  25                  30 

Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe
         35                  40                  45 

Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala
     50                  55                  60 

Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys
 65                  70                  75                  80 

Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val
                 85                  90                  95 

Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala
            100                 105                 110 

Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp
        115                 120                 125 

Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser
    130                 135                 140 

Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser
145                 150                 155                 160 

Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala
                165                 170                 175 

Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro
            180                 185                 190 

Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro
        195                 200                 205 

Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr
    210                 215                 220 

Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys
225                 230                 235            


<210>    9
<211>    202
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SK-E-RBD-P2


<400>    9
Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu
  1               5                  10                  15 

Gly Ser Gly Ser Gly Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg
             20                  25                  30 

Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val
         35                  40                  45 

Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys
     50                  55                  60 

Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn
 65                  70                  75                  80 

Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile
                 85                  90                  95 

Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro
            100                 105                 110 

Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp
        115                 120                 125 

Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys
    130                 135                 140 

Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln
145                 150                 155                 160 

Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe
                165                 170                 175 

Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln
            180                 185                 190 

Pro Tyr Arg Val Val Val Leu Ser Phe Glu
        195                 200        


<210>    10
<211>    270
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SK-E-RBD-Ex3-foldon-P2


<400>    10
Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu
  1               5                  10                  15 

Gly Ser Gly Ser Gly Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn
             20                  25                  30 

Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe
         35                  40                  45 

Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala
     50                  55                  60 

Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys
 65                  70                  75                  80 

Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val
                 85                  90                  95 

Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala
            100                 105                 110 

Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp
        115                 120                 125 

Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser
    130                 135                 140 

Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser
145                 150                 155                 160 

Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala
                165                 170                 175 

Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro
            180                 185                 190 

Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro
        195                 200                 205 

Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr
    210                 215                 220 

Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Gly Ser
225                 230                 235                 240 

Gly Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr
                245                 250                 255 

Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu
            260                 265                 270


<210>    11
<211>    2085
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the optimized codon of SK-E-S1-P2


<400>    11
atgcagtata taaaagcaaa ttctaaattt ataggtataa ctgaactagg ctccggctca         60

ggccagtgtg ttaatcttac aaccagaact caattacccc ctgcatacac taattctttc        120

acacgtggtg tttattaccc tgacaaagtt ttcagatcct cagttttaca ttcaactcag        180

gacttgttct tacctttctt ttccaatgtt acttggttcc atgctataca tgtctctggg        240

accaatggta ctaagaggtt tgataaccct gtcctaccat ttaatgatgg tgtttatttt        300

gcttccactg agaagtctaa cataataaga ggctggattt ttggtactac tttagattcg        360

aagacccagt ccctacttat tgttaataac gctactaatg ttgttattaa agtctgtgaa        420

tttcaatttt gtaatgatcc atttttgggt gtttattacc acaaaaacaa caaaagttgg        480

atggaaagtg agttcagagt ttattctagt gcgaataatt gcacttttga atatgtctct        540

cagccttttc ttatggacct tgaaggaaaa cagggtaatt tcaaaaatct tagggaattt        600

gtgtttaaga atattgatgg ttattttaaa atatattcta agcacacgcc tattaattta        660

gtgcgtgatc tccctcaggg tttttcggct ttagaaccat tggtagattt gccaataggt        720

attaacatca ctaggtttca aactttactt gctttacata gaagttattt gactcctggt        780

gattcttctt caggttggac agctggtgct gcagcttatt atgtgggtta tcttcaacct        840

aggacttttc tattaaaata taatgaaaat ggaaccatta cagatgctgt agactgtgca        900

cttgaccctc tctcagaaac aaagtgtacg ttgaaatcct tcactgtaga aaaaggaatc        960

tatcaaactt ctaactttag agtccaacca acagaatcta ttgttagatt tcctaatatt       1020

acaaacttgt gcccttttgg tgaagttttt aacgccacca gatttgcatc tgtttatgct       1080

tggaacagga agagaatcag caactgtgtt gctgattatt ctgtcctata taattccgca       1140

tcattttcca cttttaagtg ttatggagtg tctcctacta aattaaatga tctctgcttt       1200

actaatgtct atgcagattc atttgtaatt agaggtgatg aagtcagaca aatcgctcca       1260

gggcaaactg gaaagattgc tgattataat tataaattac cagatgattt tacaggctgc       1320

gttatagctt ggaattctaa caatcttgat tctaaggttg gtggtaatta taattacctg       1380

tatagattgt ttaggaagtc taatctcaaa ccttttgaga gagatatttc aactgaaatc       1440

tatcaggccg gtagcacacc ttgtaatggt gttgaaggtt ttaattgtta ctttccttta       1500

caatcttatg gtttccaacc cactaatggt gttggttacc aaccatacag agtagtagta       1560

ctttcttttg aacttctaca tgcaccagca actgtttgtg gacctaaaaa gtctactaat       1620

ttggttaaaa acaaatgtgt caatttcaac ttcaatggtt taacaggcac aggtgttctt       1680

actgagtcta acaaaaagtt tctgcctttc caacaatttg gcagagacat tgctgacact       1740

actgatgctg tccgtgatcc acagacactt gagattcttg acattacacc atgttctttt       1800

ggtggtgtca gtgttataac accaggaaca aatacttcta accaggttgc tgttctttat       1860

caggatgtta actgcacaga agtccctgtt gctattcatg cagatcaact tactcctact       1920

tggcgtgttt attctacagg ttctaatgtt tttcaaacac gtgcaggctg tttaataggg       1980

gctgaacatg tcaacaactc ttatgagtgt gacataccca ttggtgcagg tatatgcgct       2040

agttatcaga ctcagactaa ttctcctcgg cgggcacgta gttga                       2085


<210>    12
<211>    873
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the optimized codon of SK-E-S1-T1-P2


<400>    12
atgcagtata taaaagcaaa ttctaaattt ataggtataa ctgaactagg ctccggctca         60

ggcaccgaaa gcattgttcg tttcccgaac atcaccaacc tgtgcccgtt tggcgaggtg        120

ttcaacgcga cccgtttcgc gagcgtttat gcgtggaacc gtaaacgtat cagcaactgc        180

gttgcggatt atagcgtgct gtacaacagc gcgagcttca gcacctttaa gtgctatggt        240

gttagcccga ccaaactgaa cgacctgtgc tttaccaacg tttacgcgga tagcttcgtg        300

attcgtggcg acgaagttcg tcagatcgcg ccgggtcaaa ccggcaagat tgcggattac        360

aactataaac tgccggacga tttcaccggt tgcgtgattg cgtggaacag caacaacctg        420

gacagcaagg ttggtggcaa ctacaactat ctgtaccgtc tgtttcgtaa gagcaacctg        480

aaaccgttcg agcgtgatat tagcaccgaa atctaccagg cgggtagcac cccgtgcaac        540

ggtgtggaag gctttaactg ctatttcccg ctgcagagct acggctttca accgaccaac        600

ggtgttggct atcaaccgta ccgtgtggtt gttctgagct tcgagctgct gcatgcgccg        660

gcgaccgttt gcggtccgaa gaaaagcacc aacctggtta agaacaaatg cgtgaacttc        720

aactttaacg gcctgaccgg caccggtgtg ctgaccgaaa gcaacaagaa attcctgccg        780

tttcagcaat tcggtcgtga catcgcggat accaccgacg cggttcgtga tccgcagacc        840

ctggagattc tggacatcac cccgtgcagc taa                                     873


<210>    13
<211>    714
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the optimized codon of SK-E-RBD-Ex3-P2


<400>    13
atgcagtata taaaagcaaa ttctaaattt ataggtataa ctgaactagg ctccggctca         60

ggccaaccga ccgaaagcat tgttcgtttc ccgaacatca ccaacctgtg cccgtttggc        120

gaggtgttca acgcgacccg tttcgcgagc gtttatgcgt ggaaccgtaa acgtatcagc        180

aactgcgttg cggattatag cgtgctgtac aacagcgcga gcttcagcac ctttaagtgc        240

tatggtgtta gcccgaccaa actgaacgac ctgtgcttta ccaacgttta cgcggatagc        300

ttcgtgattc gtggcgacga agttcgtcag atcgcgccgg gtcaaaccgg caagattgcg        360

gattacaact ataaactgcc ggacgatttc accggttgcg tgattgcgtg gaacagcaac        420

aacctggaca gcaaggttgg tggcaactac aactatctgt accgtctgtt tcgtaagagc        480

aacctgaaac cgttcgagcg tgatattagc accgaaatct accaggcggg tagcaccccg        540

tgcaacggtg tggaaggctt taactgctat ttcccgctgc agagctacgg ctttcaaccg        600

accaacggtg ttggctatca accgtaccgt gtggttgttc tgagcttcga gctgctgcat        660

gcgccggcga ccgtttgcgg tccgaagaaa agcaccaacc tggttaagaa caaa              714


<210>    14
<211>    609
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the optimized codon of SK-E-RBD-P2


<400>    14
atgcagtata taaaagcaaa ttctaaattt ataggtataa ctgaactagg ctccggctca         60

ggctgccctt ttggtgaagt ttttaacgcc accagatttg catctgttta tgcttggaac        120

aggaagagaa tcagcaactg tgttgctgat tattctgtcc tatataattc cgcatcattt        180

tccactttta agtgttatgg agtgtctcct actaaattaa atgatctctg ctttactaat        240

gtctatgcag attcatttgt aattagaggt gatgaagtca gacaaatcgc tccagggcaa        300

actggaaaga ttgctgatta taattataaa ttaccagatg attttacagg ctgcgttata        360

gcttggaatt ctaacaatct tgattctaag gttggtggta attataatta cctgtataga        420

ttgtttagga agtctaatct caaacctttt gagagagata tttcaactga aatctatcag        480

gccggtagca caccttgtaa tggtgttgaa ggttttaatt gttactttcc tttacaatct        540

tatggtttcc aacccactaa tggtgttggt taccaaccat acagagtagt agtactttct        600

tttgaataa                                                                609


<210>    15
<211>    810
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the optimized codon of SK-E-RBD-Ex3-foldon-P2


<400>    15
atgcagtata taaaagcaaa ttctaaattt ataggtataa ctgaactagg ctccggctca         60

ggccaaccga ccgaaagcat tgttcgtttc ccgaacatca ccaacctgtg cccgtttggc        120

gaggtgttca acgcgacccg tttcgcgagc gtttatgcgt ggaaccgtaa acgtatcagc        180

aactgcgttg cggattatag cgtgctgtac aacagcgcga gcttcagcac ctttaagtgc        240

tatggtgtta gcccgaccaa actgaacgac ctgtgcttta ccaacgttta cgcggatagc        300

ttcgtgattc gtggcgacga agttcgtcag atcgcgccgg gtcaaaccgg caagattgcg        360

gattacaact ataaactgcc ggacgatttc accggttgcg tgattgcgtg gaacagcaac        420

aacctggaca gcaaggttgg tggcaactac aactatctgt accgtctgtt tcgtaagagc        480

aacctgaaac cgttcgagcg tgatattagc accgaaatct accaggcggg tagcaccccg        540

tgcaacggtg tggaaggctt taactgctat ttcccgctgc agagctacgg ctttcaaccg        600

accaacggtg ttggctatca accgtaccgt gtggttgttc tgagcttcga gctgctgcat        660

gcgccggcga ccgtttgcgg tccgaagaaa agcaccaacc tggttaagaa caaaggtagc        720

ggtggcagcg gttacatccc tgaagctccc cgcgacggac aggcctacgt ccgtaaggac        780

ggagaatggg tactcctgtc tacgttcctg                                         810


<210>    16
<211>    439
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    SK-E-N


<400>    16
Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu
  1               5                  10                  15 

Gly Ser Gly Ser Gly Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala
             20                  25                  30 

Pro Arg Ile Thr Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln
         35                  40                  45 

Asn Gly Glu Arg Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly
     50                  55                  60 

Leu Pro Asn Asn Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly
 65                  70                  75                  80 

Lys Glu Asp Leu Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr
                 85                  90                  95 

Asn Ser Ser Pro Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg
            100                 105                 110 

Arg Ile Arg Gly Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp
        115                 120                 125 

Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly
    130                 135                 140 

Ala Asn Lys Asp Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn
145                 150                 155                 160 

Thr Pro Lys Asp His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala
                165                 170                 175 

Ile Val Leu Gln Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr
            180                 185                 190 

Ala Glu Gly Ser Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser
        195                 200                 205 

Arg Ser Arg Asn Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly
    210                 215                 220 

Thr Ser Pro Ala Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala
225                 230                 235                 240 

Leu Leu Leu Leu Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly
                245                 250                 255 

Lys Gly Gln Gln Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala
            260                 265                 270 

Glu Ala Ser Lys Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr
        275                 280                 285 

Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly
    290                 295                 300 

Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His
305                 310                 315                 320 

Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly
                325                 330                 335 

Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr
            340                 345                 350 

Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp
        355                 360                 365 

Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro
    370                 375                 380 

Pro Thr Glu Pro Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln
385                 390                 395                 400 

Ala Leu Pro Gln Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro
                405                 410                 415 

Ala Ala Asp Leu Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser
            420                 425                 430 

Ser Ala Asp Ser Thr Gln Ala
        435                


<210>    17
<211>    2022
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the nucleotide sequences encoding the fragment from 14 to 686
         amino acids of S protein


<400>    17
caatgcgtta atctgaccac ccgcacccaa ctgccgccgg cgtacaccaa tagcttcacc         60

cgtggcgttt actacccgga caaggttttc cgtagcagcg tgctgcacag cacccaggac        120

ctgtttctgc cgttctttag caacgtgacc tggttccacg cgatccacgt tagcggcacc        180

aacggcacca aacgttttga taacccggtg ctgccgttta acgacggtgt ttacttcgcg        240

agcaccgaaa agagcaacat cattcgtggt tggattttcg gcaccaccct ggatagcaaa        300

acccagagcc tgctgatcgt gaacaacgcg accaacgtgg ttattaaggt ttgcgagttc        360

caattttgca acgacccgtt tctgggcgtg tactatcaca agaacaacaa aagctggatg        420

gagagcgagt tccgtgtgta tagcagcgcg aacaactgca cctttgagta cgttagccag        480

ccgttcctga tggatctgga aggcaagcaa ggcaacttta aaaacctgcg tgagttcgtt        540

ttcaagaaca tcgacggtta cttcaaaatc tacagcaaac acaccccgat caacctggtg        600

cgtgatctgc cgcagggttt tagcgcgctg gaaccgctgg ttgacctgcc gatcggcatt        660

aacatcaccc gtttccaaac cctgctggcg ctgcaccgta gctacctgac cccgggtgac        720

agcagcagcg gttggaccgc gggtgctgcg gcgtactatg tgggttatct gcagccgcgt        780

acctttctgc tgaaatacaa cgagaacggc accatcaccg atgcggtgga ttgcgcgctg        840

gacccgctga gcgaaaccaa gtgcaccctg aagagcttca ccgttgagaa gggtatttac        900

cagaccagca actttcgtgt gcaaccgacc gaaagcattg ttcgtttccc gaacatcacc        960

aacctgtgcc cgtttggcga ggtgttcaac gcgacccgtt tcgcgagcgt ttatgcgtgg       1020

aaccgtaaac gtatcagcaa ctgcgttgcg gattatagcg tgctgtacaa cagcgcgagc       1080

ttcagcacct ttaagtgcta tggtgttagc ccgaccaaac tgaacgacct gtgctttacc       1140

aacgtttacg cggatagctt cgtgattcgt ggcgacgaag ttcgtcagat cgcgccgggt       1200

caaaccggca agattgcgga ttacaactat aaactgccgg acgatttcac cggttgcgtg       1260

attgcgtgga acagcaacaa cctggacagc aaggttggtg gcaactacaa ctatctgtac       1320

cgtctgtttc gtaagagcaa cctgaaaccg ttcgagcgtg atattagcac cgaaatctac       1380

caggcgggta gcaccccgtg caacggtgtg gaaggcttta actgctattt cccgctgcag       1440

agctacggct ttcaaccgac caacggtgtt ggctatcaac cgtaccgtgt ggttgttctg       1500

agcttcgagc tgctgcatgc gccggcgacc gtttgcggtc cgaagaaaag caccaacctg       1560

gttaagaaca aatgcgtgaa cttcaacttt aacggcctga ccggcaccgg tgtgctgacc       1620

gaaagcaaca agaaattcct gccgtttcag caattcggtc gtgacatcgc ggataccacc       1680

gacgcggttc gtgatccgca gaccctggag attctggaca tcaccccgtg cagctttggt       1740

ggcgttagcg tgatcacccc gggcaccaac accagcaacc aggttgcggt gctgtatcaa       1800

gatgtgaact gcaccgaggt tccggtggcg attcatgcgg accagctgac cccgacctgg       1860

cgtgtgtaca gcaccggtag caacgttttc caaacccgtg cgggttgcct gattggtgcg       1920

gagcacgtta acaacagcta tgaatgcgac attccgatcg gcgcgggtat ttgcgcgagc       1980

tatcagaccc agaccaacag cccgcgtcgt gcgcgtagct aa                          2022


<210>    18
<211>    807
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the nucleotide sequences encoding the fragment from 323 to 591
         amino acids of S protein


<400>    18
accgaaagca ttgttcgttt cccgaacatc accaacctgt gcccgtttgg cgaggtgttc         60

aacgcgaccc gtttcgcgag cgtttatgcg tggaaccgta aacgtatcag caactgcgtt        120

gcggattata gcgtgctgta caacagcgcg agcttcagca cctttaagtg ctatggtgtt        180

agcccgacca aactgaacga cctgtgcttt accaacgttt acgcggatag cttcgtgatt        240

cgtggcgacg aagttcgtca gatcgcgccg ggtcaaaccg gcaagattgc ggattacaac        300

tataaactgc cggacgattt caccggttgc gtgattgcgt ggaacagcaa caacctggac        360

agcaaggttg gtggcaacta caactatctg taccgtctgt ttcgtaagag caacctgaaa        420

ccgttcgagc gtgatattag caccgaaatc taccaggcgg gtagcacccc gtgcaacggt        480

gtggaaggct ttaactgcta tttcccgctg cagagctacg gctttcaacc gaccaacggt        540

gttggctatc aaccgtaccg tgtggttgtt ctgagcttcg agctgctgca tgcgccggcg        600

accgtttgcg gtccgaagaa aagcaccaac ctggttaaga acaaatgcgt gaacttcaac        660

tttaacggcc tgaccggcac cggtgtgctg accgaaagca acaagaaatt cctgccgttt        720

cagcaattcg gtcgtgacat cgcggatacc accgacgcgg ttcgtgatcc gcagaccctg        780

gagattctgg acatcacccc gtgcagc                                            807


<210>    19
<211>    651
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the nucleotide sequences encoding the fragment from 321 to 537
         amino acids of S protein


<400>    19
caaccgaccg aaagcattgt tcgtttcccg aacatcacca acctgtgccc gtttggcgag         60

gtgttcaacg cgacccgttt cgcgagcgtt tatgcgtgga accgtaaacg tatcagcaac        120

tgcgttgcgg attatagcgt gctgtacaac agcgcgagct tcagcacctt taagtgctat        180

ggtgttagcc cgaccaaact gaacgacctg tgctttacca acgtttacgc ggatagcttc        240

gtgattcgtg gcgacgaagt tcgtcagatc gcgccgggtc aaaccggcaa gattgcggat        300

tacaactata aactgccgga cgatttcacc ggttgcgtga ttgcgtggaa cagcaacaac        360

ctggacagca aggttggtgg caactacaac tatctgtacc gtctgtttcg taagagcaac        420

ctgaaaccgt tcgagcgtga tattagcacc gaaatctacc aggcgggtag caccccgtgc        480

aacggtgtgg aaggctttaa ctgctatttc ccgctgcaga gctacggctt tcaaccgacc        540

aacggtgttg gctatcaacc gtaccgtgtg gttgttctga gcttcgagct gctgcatgcg        600

ccggcgaccg tttgcggtcc gaagaaaagc accaacctgg ttaagaacaa a                 651


<210>    20
<211>    543
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the nucleotide sequences encoding the fragment from 336 to 516
         amino acids of S protein


<400>    20
tgcccgtttg gcgaggtgtt caacgcgacc cgtttcgcga gcgtttatgc gtggaaccgt         60

aaacgtatca gcaactgcgt tgcggattat agcgtgctgt acaacagcgc gagcttcagc        120

acctttaagt gctatggtgt tagcccgacc aaactgaacg acctgtgctt taccaacgtt        180

tacgcggata gcttcgtgat tcgtggcgac gaagttcgtc agatcgcgcc gggtcaaacc        240

ggcaagattg cggattacaa ctataaactg ccggacgatt tcaccggttg cgtgattgcg        300

tggaacagca acaacctgga cagcaaggtt ggtggcaact acaactatct gtaccgtctg        360

tttcgtaaga gcaacctgaa accgttcgag cgtgatatta gcaccgaaat ctaccaggcg        420

ggtagcaccc cgtgcaacgg tgtggaaggc tttaactgct atttcccgct gcagagctac        480

ggctttcaac cgaccaacgg tgttggctat caaccgtacc gtgtggttgt tctgagcttc        540

gag                                                                      543


<210>    21
<211>    27
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    foldon domain


<400>    21
Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys
  1               5                  10                  15 

Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu
             20                  25        


<210>    22
<211>    1260
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    the optimized codon of SK-E-N


<400>    22
atgtctgata atggacccca aaatcagcga aatgcacccc gcattacgtt tggtggaccc         60

tcagattcaa ctggcagtaa ccagaatgga gaacgcagtg gggcgcgatc aaaacaacgt        120

cggccccaag gtttacccaa taatactgcg tcttggttca ccgctctcac tcaacatggc        180

aaggaagacc ttaaattccc tcgaggacaa ggcgttccaa ttaacaccaa tagcagtcca        240

gatgaccaaa ttggctacta ccgaagagct accagacgaa ttcgtggtgg tgacggtaaa        300

atgaaagatc tcagtccaag atggtatttc tactacctag gaactgggcc agaagctgga        360

cttccctatg gtgctaacaa agacggcatc atttgggttg caactgaggg agccttgaat        420

acaccaaaag atcacattgg cacccgcaat cctgctaaca atgctgcaat cgtgctacaa        480

cttcctcaag gaacaacatt gccaaaaggc ttctacgcag aagggagcag aggcggcagt        540

caagcctctt ctcgttcctc atcacgtagt cgcaacagtt caagaaattc aactccaggc        600

agcagtaggg gaacttctcc tgctagaatg gctggcaatg gcggtgatgc tgctcttgct        660

ttgctgctgc ttgacagatt gaaccagctt gagagcaaaa tgtctggtaa aggccaacaa        720

caacaaggcc aaactgtcac taagaaatct gctgctgagg cttctaagaa gcctcggcaa        780

aaacgtactg ccactaaagc atacaatgta acacaagctt tcggcagacg tggtccagaa        840

caaacccaag gaaattttgg ggaccaggaa ctaatcagac aaggaactga ttacaaacat        900

tggccgcaaa ttgcacaatt tgcccccagc gcttcagcgt tcttcggaat gtcgcgcatt        960

ggcatggaag tcacaccttc gggaacgtgg ttgacctaca caggtgccat caaattggat       1020

gacaaagatc caaatttcaa agatcaagtc attttgctga ataagcatat tgacgcatac       1080

aaaacattcc caccaacaga gcctaaaaag gacaaaaaga agaaggctga tgaaactcaa       1140

gccttaccgc agagacagaa gaaacagcaa actgtgactc ttcttcctgc tgcagatttg       1200

gatgatttct ccaaacaatt gcaacaatcc atgagcagtg ctgactcaac tcaggcctaa       1260

                                                                        1260


<210>    23
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    GSGSG linker


<400>    23
Gly Ser Gly Ser Gly
  1               5


<210>    24
<211>    4
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    GSSG linker


<400>    24
Gly Ser Ser Gly
  1            


<210>    25
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    GSGGS linker


<400>    25
Gly Ser Gly Gly Ser
  1               5


<210>    26
<211>    4
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    GSGS linker


<400>    26
Gly Ser Gly Ser
  1            


<210>    27
<211>    6
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    GSGSSG linker


<400>    27
Gly Ser Gly Ser Ser Gly
  1               5    


<210>    28
<211>    21
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    pelB leader sequence


<400>    28
Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala Ala
  1               5                  10                  15 

Gln Pro Ala Met Ala
             20    
