                         SEQUENCE LISTING

<110>  Kiniksa Pharmaceuticals, Ltd.
       Kiniksa Pharmaceuticals Corp.
 
<120>  TREATMENT OF CANCERS WITH GM-CSF ANTAGONISTS

<130>  KPL-035BWO

<150>  63/105,773
<151>  2020-10-26

<150>  63/120,319
<151>  2020-12-02

<150>  63/242,849
<151>  2021-09-10

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Glu Asn Glu Ile Val Tyr Ala Gln Arg Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Val Gly Ser Phe Ser Pro Leu Thr Leu Gly Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  2
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Gly Ser Asn Ile Gly Ala Pro 
            20                  25                  30          


Tyr Asp Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr His Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Val Glu Ala Gly 
                85                  90                  95      


Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Glu Leu Ser Ile His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gly Phe Asp Pro Glu Glu Asn Glu Ile Val Tyr Ala Gln Arg Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Val Gly Ser Phe Ser Pro Leu Thr Leu Gly Leu 
1               5                   10      


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Thr Gly Ser Gly Ser Asn Ile Gly Ala Pro Tyr Asp Val Ser 
1               5                   10                  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

His Asn Asn Lys Arg Pro Ser 
1               5           


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Ala Thr Val Glu Ala Gly Leu Ser Gly Ser Val 
1               5                   10      


<210>  9
<211>  5430
<212>  DNA
<213>  Homo sapiens

<400>  9
ctaggcggcg gccgcggcgg cggaggcagc agcggcggcg gcagtggcgg cggcgaaggt       60

ggcggcggct cggccagtac tcccggcccc cgccatttcg gactgggagc gagcgcggcg      120

caggcactga aggcggcggc ggggccagag gctcagcggc tcccaggtgc gggagagagg      180

cctgctgaaa atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag      240

tgccttgacg atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga      300

ggattcctac aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga      360

cacagcaggt caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg      420

ctttctttgt gtatttgcca taaataatac taaatcattt gaagatattc accattatag      480

agaacaaatt aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa      540

atgtgatttg ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta      600

tggaattcct tttattgaaa catcagcaaa gacaagacag agagtggagg atgcttttta      660

tacattggtg agagagatcc gacaatacag attgaaaaaa atcagcaaag aagaaaagac      720

tcctggctgt gtgaaaatta aaaaatgcat tataatgtaa tctgggtgtt gatgatgcct      780

tctatacatt agttcgagaa attcgaaaac ataaagaaaa gatgagcaaa gatggtaaaa      840

agaagaaaaa gaagtcaaag acaaagtgtg taattatgta aatacaattt gtactttttt      900

cttaaggcat actagtacaa gtggtaattt ttgtacatta cactaaatta ttagcatttg      960

ttttagcatt acctaatttt tttcctgctc catgcagact gttagctttt accttaaatg     1020

cttattttaa aatgacagtg gaagtttttt tttcctctaa gtgccagtat tcccagagtt     1080

ttggtttttg aactagcaat gcctgtgaaa aagaaactga atacctaaga tttctgtctt     1140

ggggcttttg gtgcatgcag ttgattactt cttatttttc ttaccaattg tgaatgttgg     1200

tgtgaaacaa attaatgaag cttttgaatc atccctattc tgtgttttat ctagtcacat     1260

aaatggatta attactaatt tcagttgaga ccttctaatt ggtttttact gaaacattga     1320

gggaacacaa atttatgggc ttcctgatga tgattcttct aggcatcatg tcctatagtt     1380

tgtcatccct gatgaatgta aagttacact gttcacaaag gttttgtctc ctttccactg     1440

ctattagtca tggtcactct ccccaaaata ttatattttt tctataaaaa gaaaaaaatg     1500

gaaaaaaatt acaaggcaat ggaaactatt ataaggccat ttccttttca cattagataa     1560

attactataa agactcctaa tagcttttcc tgttaaggca gacccagtat gaaatgggga     1620

ttattatagc aaccattttg gggctatatt tacatgctac taaattttta taataattga     1680

aaagatttta acaagtataa aaaattctca taggaattaa atgtagtctc cctgtgtcag     1740

actgctcttt catagtataa ctttaaatct tttcttcaac ttgagtcttt gaagatagtt     1800

ttaattctgc ttgtgacatt aaaagattat ttgggccagt tatagcttat taggtgttga     1860

agagaccaag gttgcaaggc caggccctgt gtgaaccttt gagctttcat agagagtttc     1920

acagcatgga ctgtgtcccc acggtcatcc agtgttgtca tgcattggtt agtcaaaatg     1980

gggagggact agggcagttt ggatagctca acaagataca atctcactct gtggtggtcc     2040

tgctgacaaa tcaagagcat tgcttttgtt tcttaagaaa acaaactctt ttttaaaaat     2100

tacttttaaa tattaactca aaagttgaga ttttggggtg gtggtgtgcc aagacattaa     2160

tttttttttt aaacaatgaa gtgaaaaagt tttacaatct ctaggtttgg ctagttctct     2220

taacactggt taaattaaca ttgcataaac acttttcaag tctgatccat atttaataat     2280

gctttaaaat aaaaataaaa acaatccttt tgataaattt aaaatgttac ttattttaaa     2340

ataaatgaag tgagatggca tggtgaggtg aaagtatcac tggactagga agaaggtgac     2400

ttaggttcta gataggtgtc ttttaggact ctgattttga ggacatcact tactatccat     2460

ttcttcatgt taaaagaagt catctcaaac tcttagtttt ttttttttac aactatgtaa     2520

tttatattcc atttacataa ggatacactt atttgtcaag ctcagcacaa tctgtaaatt     2580

tttaacctat gttacaccat cttcagtgcc agtcttgggc aaaattgtgc aagaggtgaa     2640

gtttatattt gaatatccat tctcgtttta ggactcttct tccatattag tgtcatcttg     2700

cctccctacc ttccacatgc cccatgactt gatgcagttt taatacttgt aattccccta     2760

accataagat ttactgctgc tgtggatatc tccatgaagt tttcccactg agtcacatca     2820

gaaatgccct acatcttatt tcctcagggc tcaagagaat ctgacagata ccataaaggg     2880

atttgaccta atcactaatt ttcaggtggt ggctgatgct ttgaacatct ctttgctgcc     2940

caatccatta gcgacagtag gatttttcaa acctggtatg aatagacaga accctatcca     3000

gtggaaggag aatttaataa agatagtgct gaaagaattc cttaggtaat ctataactag     3060

gactactcct ggtaacagta atacattcca ttgttttagt aaccagaaat cttcatgcaa     3120

tgaaaaatac tttaattcat gaagcttact tttttttttt ggtgtcagag tctcgctctt     3180

gtcacccagg ctggaatgca gtggcgccat ctcagctcac tgcaacctcc atctcccagg     3240

ttcaagcgat tctcgtgcct cggcctcctg agtagctggg attacaggcg tgtgccacta     3300

cactcaacta atttttgtat ttttaggaga gacggggttt caccctgttg gccaggctgg     3360

tctcgaactc ctgacctcaa gtgattcacc caccttggcc tcataaacct gttttgcaga     3420

actcatttat tcagcaaata tttattgagt gcctaccaga tgccagtcac cacacaaggc     3480

actgggtata tggtatcccc aaacaagaga cataatcccg gtccttaggt agtgctagtg     3540

tggtctgtaa tatcttacta aggcctttgg tatacgaccc agagataaca cgatgcgtat     3600

tttagttttg caaagaaggg gtttggtctc tgtgccagct ctataattgt tttgctacga     3660

ttccactgaa actcttcgat caagctactt tatgtaaatc acttcattgt tttaaaggaa     3720

taaacttgat tatattgttt ttttatttgg cataactgtg attcttttag gacaattact     3780

gtacacatta aggtgtatgt cagatattca tattgaccca aatgtgtaat attccagttt     3840

tctctgcata agtaattaaa atatacttaa aaattaatag ttttatctgg gtacaaataa     3900

acaggtgcct gaactagttc acagacaagg aaacttctat gtaaaaatca ctatgatttc     3960

tgaattgcta tgtgaaacta cagatctttg gaacactgtt taggtagggt gttaagactt     4020

acacagtacc tcgtttctac acagagaaag aaatggccat acttcaggaa ctgcagtgct     4080

tatgagggga tatttaggcc tcttgaattt ttgatgtaga tgggcatttt tttaaggtag     4140

tggttaatta cctttatgtg aactttgaat ggtttaacaa aagatttgtt tttgtagaga     4200

ttttaaaggg ggagaattct agaaataaat gttacctaat tattacagcc ttaaagacaa     4260

aaatccttgt tgaagttttt ttaaaaaaag ctaaattaca tagacttagg cattaacatg     4320

tttgtggaag aatatagcag acgtatattg tatcatttga gtgaatgttc ccaagtaggc     4380

attctaggct ctatttaact gagtcacact gcataggaat ttagaaccta acttttatag     4440

gttatcaaaa ctgttgtcac cattgcacaa ttttgtccta atatatacat agaaactttg     4500

tggggcatgt taagttacag tttgcacaag ttcatctcat ttgtattcca ttgatttttt     4560

ttttcttcta aacatttttt cttcaaacag tatataactt tttttagggg attttttttt     4620

agacagcaaa aactatctga agatttccat ttgtcaaaaa gtaatgattt cttgataatt     4680

gtgtagtaat gttttttaga acccagcagt taccttaaag ctgaatttat atttagtaac     4740

ttctgtgtta atactggata gcatgaattc tgcattgaga aactgaatag ctgtcataaa     4800

atgaaacttt ctttctaaag aaagatactc acatgagttc ttgaagaata gtcataacta     4860

gattaagatc tgtgttttag tttaatagtt tgaagtgcct gtttgggata atgataggta     4920

atttagatga atttagggga aaaaaaagtt atctgcagat atgttgaggg cccatctctc     4980

cccccacacc cccacagagc taactgggtt acagtgtttt atccgaaagt ttccaattcc     5040

actgtcttgt gttttcatgt tgaaaatact tttgcatttt tcctttgagt gccaatttct     5100

tactagtact atttcttaat gtaacatgtt tacctggaat gtattttaac tatttttgta     5160

tagtgtaaac tgaaacatgc acattttgta cattgtgctt tcttttgtgg gacatatgca     5220

gtgtgatcca gttgttttcc atcatttggt tgcgctgacc taggaatgtt ggtcatatca     5280

aacattaaaa atgaccactc ttttaattga aattaacttt taaatgttta taggagtatg     5340

tgctgtgaag tgatctaaaa tttgtaatat ttttgtcatg aactgtacta ctcctaatta     5400

ttgtaatgta ataaaaatag ttacagtgac                                      5430


<210>  10
<211>  5306
<212>  DNA
<213>  Homo sapiens

<400>  10
ctaggcggcg gccgcggcgg cggaggcagc agcggcggcg gcagtggcgg cggcgaaggt       60

ggcggcggct cggccagtac tcccggcccc cgccatttcg gactgggagc gagcgcggcg      120

caggcactga aggcggcggc ggggccagag gctcagcggc tcccaggtgc gggagagagg      180

cctgctgaaa atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag      240

tgccttgacg atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga      300

ggattcctac aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga      360

cacagcaggt caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg      420

ctttctttgt gtatttgcca taaataatac taaatcattt gaagatattc accattatag      480

agaacaaatt aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa      540

atgtgatttg ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta      600

tggaattcct tttattgaaa catcagcaaa gacaagacag ggtgttgatg atgccttcta      660

tacattagtt cgagaaattc gaaaacataa agaaaagatg agcaaagatg gtaaaaagaa      720

gaaaaagaag tcaaagacaa agtgtgtaat tatgtaaata caatttgtac ttttttctta      780

aggcatacta gtacaagtgg taatttttgt acattacact aaattattag catttgtttt      840

agcattacct aatttttttc ctgctccatg cagactgtta gcttttacct taaatgctta      900

ttttaaaatg acagtggaag tttttttttc ctctaagtgc cagtattccc agagttttgg      960

tttttgaact agcaatgcct gtgaaaaaga aactgaatac ctaagatttc tgtcttgggg     1020

cttttggtgc atgcagttga ttacttctta tttttcttac caattgtgaa tgttggtgtg     1080

aaacaaatta atgaagcttt tgaatcatcc ctattctgtg ttttatctag tcacataaat     1140

ggattaatta ctaatttcag ttgagacctt ctaattggtt tttactgaaa cattgaggga     1200

acacaaattt atgggcttcc tgatgatgat tcttctaggc atcatgtcct atagtttgtc     1260

atccctgatg aatgtaaagt tacactgttc acaaaggttt tgtctccttt ccactgctat     1320

tagtcatggt cactctcccc aaaatattat attttttcta taaaaagaaa aaaatggaaa     1380

aaaattacaa ggcaatggaa actattataa ggccatttcc ttttcacatt agataaatta     1440

ctataaagac tcctaatagc ttttcctgtt aaggcagacc cagtatgaaa tggggattat     1500

tatagcaacc attttggggc tatatttaca tgctactaaa tttttataat aattgaaaag     1560

attttaacaa gtataaaaaa ttctcatagg aattaaatgt agtctccctg tgtcagactg     1620

ctctttcata gtataacttt aaatcttttc ttcaacttga gtctttgaag atagttttaa     1680

ttctgcttgt gacattaaaa gattatttgg gccagttata gcttattagg tgttgaagag     1740

accaaggttg caaggccagg ccctgtgtga acctttgagc tttcatagag agtttcacag     1800

catggactgt gtccccacgg tcatccagtg ttgtcatgca ttggttagtc aaaatgggga     1860

gggactaggg cagtttggat agctcaacaa gatacaatct cactctgtgg tggtcctgct     1920

gacaaatcaa gagcattgct tttgtttctt aagaaaacaa actctttttt aaaaattact     1980

tttaaatatt aactcaaaag ttgagatttt ggggtggtgg tgtgccaaga cattaatttt     2040

ttttttaaac aatgaagtga aaaagtttta caatctctag gtttggctag ttctcttaac     2100

actggttaaa ttaacattgc ataaacactt ttcaagtctg atccatattt aataatgctt     2160

taaaataaaa ataaaaacaa tccttttgat aaatttaaaa tgttacttat tttaaaataa     2220

atgaagtgag atggcatggt gaggtgaaag tatcactgga ctaggaagaa ggtgacttag     2280

gttctagata ggtgtctttt aggactctga ttttgaggac atcacttact atccatttct     2340

tcatgttaaa agaagtcatc tcaaactctt agtttttttt ttttacaact atgtaattta     2400

tattccattt acataaggat acacttattt gtcaagctca gcacaatctg taaattttta     2460

acctatgtta caccatcttc agtgccagtc ttgggcaaaa ttgtgcaaga ggtgaagttt     2520

atatttgaat atccattctc gttttaggac tcttcttcca tattagtgtc atcttgcctc     2580

cctaccttcc acatgcccca tgacttgatg cagttttaat acttgtaatt cccctaacca     2640

taagatttac tgctgctgtg gatatctcca tgaagttttc ccactgagtc acatcagaaa     2700

tgccctacat cttatttcct cagggctcaa gagaatctga cagataccat aaagggattt     2760

gacctaatca ctaattttca ggtggtggct gatgctttga acatctcttt gctgcccaat     2820

ccattagcga cagtaggatt tttcaaacct ggtatgaata gacagaaccc tatccagtgg     2880

aaggagaatt taataaagat agtgctgaaa gaattcctta ggtaatctat aactaggact     2940

actcctggta acagtaatac attccattgt tttagtaacc agaaatcttc atgcaatgaa     3000

aaatacttta attcatgaag cttacttttt ttttttggtg tcagagtctc gctcttgtca     3060

cccaggctgg aatgcagtgg cgccatctca gctcactgca acctccatct cccaggttca     3120

agcgattctc gtgcctcggc ctcctgagta gctgggatta caggcgtgtg ccactacact     3180

caactaattt ttgtattttt aggagagacg gggtttcacc ctgttggcca ggctggtctc     3240

gaactcctga cctcaagtga ttcacccacc ttggcctcat aaacctgttt tgcagaactc     3300

atttattcag caaatattta ttgagtgcct accagatgcc agtcaccaca caaggcactg     3360

ggtatatggt atccccaaac aagagacata atcccggtcc ttaggtagtg ctagtgtggt     3420

ctgtaatatc ttactaaggc ctttggtata cgacccagag ataacacgat gcgtatttta     3480

gttttgcaaa gaaggggttt ggtctctgtg ccagctctat aattgttttg ctacgattcc     3540

actgaaactc ttcgatcaag ctactttatg taaatcactt cattgtttta aaggaataaa     3600

cttgattata ttgttttttt atttggcata actgtgattc ttttaggaca attactgtac     3660

acattaaggt gtatgtcaga tattcatatt gacccaaatg tgtaatattc cagttttctc     3720

tgcataagta attaaaatat acttaaaaat taatagtttt atctgggtac aaataaacag     3780

gtgcctgaac tagttcacag acaaggaaac ttctatgtaa aaatcactat gatttctgaa     3840

ttgctatgtg aaactacaga tctttggaac actgtttagg tagggtgtta agacttacac     3900

agtacctcgt ttctacacag agaaagaaat ggccatactt caggaactgc agtgcttatg     3960

aggggatatt taggcctctt gaatttttga tgtagatggg cattttttta aggtagtggt     4020

taattacctt tatgtgaact ttgaatggtt taacaaaaga tttgtttttg tagagatttt     4080

aaagggggag aattctagaa ataaatgtta cctaattatt acagccttaa agacaaaaat     4140

ccttgttgaa gtttttttaa aaaaagctaa attacataga cttaggcatt aacatgtttg     4200

tggaagaata tagcagacgt atattgtatc atttgagtga atgttcccaa gtaggcattc     4260

taggctctat ttaactgagt cacactgcat aggaatttag aacctaactt ttataggtta     4320

tcaaaactgt tgtcaccatt gcacaatttt gtcctaatat atacatagaa actttgtggg     4380

gcatgttaag ttacagtttg cacaagttca tctcatttgt attccattga tttttttttt     4440

cttctaaaca ttttttcttc aaacagtata taactttttt taggggattt ttttttagac     4500

agcaaaaact atctgaagat ttccatttgt caaaaagtaa tgatttcttg ataattgtgt     4560

agtaatgttt tttagaaccc agcagttacc ttaaagctga atttatattt agtaacttct     4620

gtgttaatac tggatagcat gaattctgca ttgagaaact gaatagctgt cataaaatga     4680

aactttcttt ctaaagaaag atactcacat gagttcttga agaatagtca taactagatt     4740

aagatctgtg ttttagttta atagtttgaa gtgcctgttt gggataatga taggtaattt     4800

agatgaattt aggggaaaaa aaagttatct gcagatatgt tgagggccca tctctccccc     4860

cacaccccca cagagctaac tgggttacag tgttttatcc gaaagtttcc aattccactg     4920

tcttgtgttt tcatgttgaa aatacttttg catttttcct ttgagtgcca atttcttact     4980

agtactattt cttaatgtaa catgtttacc tggaatgtat tttaactatt tttgtatagt     5040

gtaaactgaa acatgcacat tttgtacatt gtgctttctt ttgtgggaca tatgcagtgt     5100

gatccagttg ttttccatca tttggttgcg ctgacctagg aatgttggtc atatcaaaca     5160

ttaaaaatga ccactctttt aattgaaatt aacttttaaa tgtttatagg agtatgtgct     5220

gtgaagtgat ctaaaatttg taatattttt gtcatgaact gtactactcc taattattgt     5280

aatgtaataa aaatagttac agtgac                                          5306


<210>  11
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  12
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


