                         SEQUENCE LISTING

<110>  THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
       Baric, Ralph S
       Martinez, David R
 
<120>  CHIMERIC CORONAVIRUS S PROTEIN COMPOSITIONS AND METHODS OF USE

<130>  5470.885.WO

<150>  63/106247
<151>  2020-10-27

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Unknown

<220>
<223>  SARS-CoV-2

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  1259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HKU3 NTD/SARS1 RBD/SARS2 S2 chimera

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Gly 
1               5                   10                  15      


Ile Ile Ser Arg Lys Pro Gln Pro Lys Met Ala Gln Val Ser Ser Ser 
            20                  25                  30          


Arg Arg Gly Val Tyr Tyr Asn Asp Asp Ile Phe Arg Ser Asp Val Leu 
        35                  40                  45              


His Leu Thr Gln Asp Tyr Phe Leu Pro Phe Asp Ser Asn Leu Thr Gln 
    50                  55                  60                  


Tyr Phe Ser Leu Asn Val Asp Ser Asp Arg Tyr Thr Tyr Phe Asp Asn 
65                  70                  75                  80  


Pro Ile Leu Asp Phe Gly Asp Gly Val Tyr Phe Ala Ala Thr Glu Lys 
                85                  90                  95      


Ser Asn Val Ile Arg Gly Trp Ile Phe Gly Ser Ser Phe Asp Asn Thr 
            100                 105                 110         


Thr Gln Ser Ala Val Ile Val Asn Asn Ser Thr His Ile Ile Ile Arg 
        115                 120                 125             


Val Cys Asn Phe Asn Leu Cys Lys Glu Pro Met Tyr Thr Val Ser Arg 
    130                 135                 140                 


Gly Thr Gln Gln Asn Ala Trp Val Tyr Gln Ser Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Tyr Asp Arg Val Glu Lys Ser Phe Gln Leu Asp Thr Thr Pro Lys Thr 
                165                 170                 175     


Gly Asn Phe Lys Asp Leu Arg Glu Tyr Val Phe Lys Asn Arg Asp Gly 
            180                 185                 190         


Phe Leu Ser Val Tyr Gln Thr Tyr Thr Ala Val Asn Leu Pro Arg Gly 
        195                 200                 205             


Leu Pro Thr Gly Phe Ser Val Leu Lys Pro Ile Leu Lys Leu Pro Phe 
    210                 215                 220                 


Gly Ile Asn Ile Thr Ser Tyr Arg Val Val Met Ala Met Phe Ser Gln 
225                 230                 235                 240 


Thr Thr Ser Asn Phe Leu Pro Glu Ser Ala Ala Tyr Tyr Val Gly Asn 
                245                 250                 255     


Leu Lys Tyr Ser Thr Phe Met Leu Arg Phe Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Thr Ile Lys Asn Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
    530                 535                 540                 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
545                 550                 555                 560 


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
            580                 585                 590         


Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val 
        595                 600                 605             


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
    610                 615                 620                 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
625                 630                 635                 640 


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
                645                 650                 655     


Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser 
            660                 665                 670         


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
705                 710                 715                 720 


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
    850                 855                 860                 


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1085                 1090                 1095             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1130                 1135                 1140             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1145                 1150                 1155             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1160                 1165                 1170             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1175                 1180                 1185             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp 
    1190                 1195                 1200             


Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile Val Met  Val Thr Ile 
    1205                 1210                 1215             


Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys 
    1220                 1225                 1230             


Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu 
    1235                 1240                 1245             


Pro Val  Leu Lys Gly Val Lys  Leu His Tyr Thr 
    1250                 1255                 


<210>  3
<211>  1256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS2 RBD/SARS1 S1 and S2 chimera

<400>  3

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys 
    530                 535                 540                 


Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr 
545                 550                 555                 560 


Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser 
            580                 585                 590         


Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser 
        595                 600                 605             


Thr Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser 
    610                 615                 620                 


Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln 
            660                 665                 670         


Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile 
        675                 680                 685             


Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser 
    690                 695                 700                 


Ile Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp 
705                 710                 715                 720 


Cys Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu 
                725                 730                 735     


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly 
            740                 745                 750         


Ile Ala Ala Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val 
        755                 760                 765             


Lys Gln Met Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn 
    770                 775                 780                 


Phe Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe 
785                 790                 795                 800 


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
                805                 810                 815     


Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu 
            820                 825                 830         


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
        835                 840                 845             


Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr 
    850                 855                 860                 


Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
865                 870                 875                 880 


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
                885                 890                 895     


Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys 
            900                 905                 910         


Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu 
        915                 920                 925             


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
    930                 935                 940                 


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
945                 950                 955                 960 


Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile 
                965                 970                 975     


Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr 
            980                 985                 990         


Gln Gln Leu Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
        995                 1000                 1005             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1010                 1015                 1020             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala 
    1025                 1030                 1035             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ser 
    1040                 1045                 1050             


Gln Glu  Arg Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly 
    1055                 1060                 1065             


Lys Ala  Tyr Phe Pro Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr 
    1070                 1075                 1080             


Ser Trp  Phe Ile Thr Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile 
    1085                 1090                 1095             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Asn Cys Asp  Val Val Ile 
    1100                 1105                 1110             


Gly Ile  Ile Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1115                 1120                 1125             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1130                 1135                 1140             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1145                 1150                 1155             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1160                 1165                 1170             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1175                 1180                 1185             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe 
    1190                 1195                 1200             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Leu Leu Cys 
    1205                 1210                 1215             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Ala  Cys Ser Cys 
    1220                 1225                 1230             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1235                 1240                 1245             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1250                 1255     


<210>  4
<211>  1272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS1 RBD/SARS2 S1 and S2 chimera

<400>  4

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala 
            340                 345                 350         


Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys 
            420                 425                 430         


Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys 
465                 470                 475                 480 


Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe 
                485                 490                 495     


Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
            500                 505                 510         


Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
        515                 520                 525             


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
    530                 535                 540                 


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
545                 550                 555                 560 


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
                565                 570                 575     


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
            580                 585                 590         


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
        595                 600                 605             


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
    610                 615                 620                 


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
625                 630                 635                 640 


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
                645                 650                 655     


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            660                 665                 670         


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        675                 680                 685             


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    690                 695                 700                 


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
705                 710                 715                 720 


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp 
                725                 730                 735     


Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu 
            740                 745                 750         


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
        755                 760                 765             


Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
    770                 775                 780                 


Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn 
785                 790                 795                 800 


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
                805                 810                 815     


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
            820                 825                 830         


Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu 
        835                 840                 845             


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
    850                 855                 860                 


Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr 
865                 870                 875                 880 


Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
                885                 890                 895     


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
            900                 905                 910         


Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser 
        915                 920                 925             


Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu 
    930                 935                 940                 


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
945                 950                 955                 960 


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
                965                 970                 975     


Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile 
            980                 985                 990         


Asp Arg Leu Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
        995                 1000                 1005             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1010                 1015                 1020             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1025                 1030                 1035             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1040                 1045                 1050             


Ser Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1055                 1060                 1065             


Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp 
    1070                 1075                 1080             


Gly Lys  Ala His Phe Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly 
    1085                 1090                 1095             


Thr His  Trp Phe Val Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile 
    1100                 1105                 1110             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1115                 1120                 1125             


Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1130                 1135                 1140             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1145                 1150                 1155             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1160                 1165                 1170             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1175                 1180                 1185             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1190                 1195                 1200             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly 
    1205                 1210                 1215             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Met Leu 
    1220                 1225                 1230             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser 
    1235                 1240                 1245             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1250                 1255                 1260             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1265                 1270         


<210>  5
<211>  1272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCH014 RBD/SARS2 S1 and S2 chimera

<400>  5

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Thr Phe Pro Ser Val Tyr Ala 
            340                 345                 350         


Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Leu Gly Cys 
            420                 425                 430         


Val Leu Ala Trp Asn Thr Asn Ser Lys Asp Ser Ser Thr Ser Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Trp Val Arg Arg Ser Lys Leu Asn Pro Tyr 
    450                 455                 460                 


Glu Arg Asp Leu Ser Asn Asp Ile Tyr Ser Pro Gly Gly Gln Ser Cys 
465                 470                 475                 480 


Ser Ala Val Gly Pro Asn Cys Tyr Asn Pro Leu Arg Pro Tyr Gly Phe 
                485                 490                 495     


Phe Thr Thr Ala Gly Val Gly His Gln Pro Tyr Arg Val Val Val Leu 
            500                 505                 510         


Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
        515                 520                 525             


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
    530                 535                 540                 


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
545                 550                 555                 560 


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
                565                 570                 575     


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
            580                 585                 590         


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
        595                 600                 605             


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
    610                 615                 620                 


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
625                 630                 635                 640 


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
                645                 650                 655     


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            660                 665                 670         


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        675                 680                 685             


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    690                 695                 700                 


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
705                 710                 715                 720 


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp 
                725                 730                 735     


Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu 
            740                 745                 750         


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
        755                 760                 765             


Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
    770                 775                 780                 


Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn 
785                 790                 795                 800 


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
                805                 810                 815     


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
            820                 825                 830         


Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu 
        835                 840                 845             


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
    850                 855                 860                 


Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr 
865                 870                 875                 880 


Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
                885                 890                 895     


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
            900                 905                 910         


Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser 
        915                 920                 925             


Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu 
    930                 935                 940                 


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
945                 950                 955                 960 


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
                965                 970                 975     


Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile 
            980                 985                 990         


Asp Arg Leu Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
        995                 1000                 1005             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1010                 1015                 1020             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1025                 1030                 1035             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1040                 1045                 1050             


Ser Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1055                 1060                 1065             


Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp 
    1070                 1075                 1080             


Gly Lys  Ala His Phe Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly 
    1085                 1090                 1095             


Thr His  Trp Phe Val Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile 
    1100                 1105                 1110             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1115                 1120                 1125             


Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1130                 1135                 1140             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1145                 1150                 1155             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1160                 1165                 1170             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1175                 1180                 1185             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1190                 1195                 1200             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly 
    1205                 1210                 1215             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Met Leu 
    1220                 1225                 1230             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser 
    1235                 1240                 1245             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1250                 1255                 1260             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1265                 1270         


<210>  6
<211>  1259
<212>  PRT
<213>  Unknown

<220>
<223>  SARS-CoV-1

<400>  6

Met Lys Ile Leu Ile Phe Ala Phe Leu Ala Asn Leu Ala Lys Ala Gln 
1               5                   10                  15      


Glu Gly Cys Gly Ile Ile Ser Arg Lys Pro Gln Pro Lys Met Ala Gln 
            20                  25                  30          


Val Ser Ser Ser Arg Arg Gly Val Tyr Tyr Asn Asp Asp Ile Phe Arg 
        35                  40                  45              


Ser Asp Val Leu His Leu Thr Gln Asp Tyr Phe Leu Pro Phe Asp Ser 
    50                  55                  60                  


Asn Leu Thr Gln Tyr Phe Ser Leu Asn Val Asp Ser Asp Arg Tyr Thr 
65                  70                  75                  80  


Tyr Phe Asp Asn Pro Ile Leu Asp Phe Gly Asp Gly Val Tyr Phe Ala 
                85                  90                  95      


Ala Thr Glu Lys Ser Asn Val Ile Arg Gly Trp Ile Phe Gly Ser Ser 
            100                 105                 110         


Phe Asp Asn Thr Thr Gln Ser Ala Val Ile Val Asn Asn Ser Thr His 
        115                 120                 125             


Ile Ile Ile Arg Val Cys Asn Phe Asn Leu Cys Lys Glu Pro Met Tyr 
    130                 135                 140                 


Thr Val Ser Arg Gly Thr Gln Gln Asn Ala Trp Val Tyr Gln Ser Ala 
145                 150                 155                 160 


Phe Asn Cys Thr Tyr Asp Arg Val Glu Lys Ser Phe Gln Leu Asp Thr 
                165                 170                 175     


Thr Pro Lys Thr Gly Asn Phe Lys Asp Leu Arg Glu Tyr Val Phe Lys 
            180                 185                 190         


Asn Arg Asp Gly Phe Leu Ser Val Tyr Gln Thr Tyr Thr Ala Val Asn 
        195                 200                 205             


Leu Pro Arg Gly Leu Pro Thr Gly Phe Ser Val Leu Lys Pro Ile Leu 
    210                 215                 220                 


Lys Leu Pro Phe Gly Ile Asn Ile Thr Ser Tyr Arg Val Val Met Ala 
225                 230                 235                 240 


Met Phe Ser Gln Thr Thr Ser Asn Phe Leu Pro Glu Ser Ala Ala Tyr 
                245                 250                 255     


Tyr Val Gly Asn Leu Lys Tyr Ser Thr Phe Met Leu Arg Phe Asn Glu 
            260                 265                 270         


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala 
        275                 280                 285             


Glu Leu Lys Cys Thr Ile Lys Asn Phe Asn Val Asp Lys Gly Ile Tyr 
    290                 295                 300                 


Gln Thr Ser Asn Phe Arg Val Ser Pro Thr Gln Glu Val Ile Arg Phe 
305                 310                 315                 320 


Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr 
                325                 330                 335     


Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys 
            340                 345                 350         


Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe 
        355                 360                 365             


Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser 
    370                 375                 380                 


Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln 
385                 390                 395                 400 


Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu 
                405                 410                 415     


Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile 
            420                 425                 430         


Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg 
        435                 440                 445             


His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe 
    450                 455                 460                 


Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp 
465                 470                 475                 480 


Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln 
                485                 490                 495     


Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala 
            500                 505                 510         


Thr Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Val Lys Asn Gln Cys 
        515                 520                 525             


Val Asn Phe Asn Phe Asn Gly Leu Lys Gly Thr Gly Val Leu Thr Ser 
    530                 535                 540                 


Ser Ser Lys Arg Phe Gln Ser Phe Gln Gln Phe Gly Arg Asp Thr Ser 
545                 550                 555                 560 


Asp Phe Thr Asp Ser Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp 
                565                 570                 575     


Ile Ser Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr 
            580                 585                 590         


Asn Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
        595                 600                 605             


Asp Val Pro Thr Ala Ile Arg Ala Asp Gln Leu Thr Pro Ala Trp Arg 
    610                 615                 620                 


Val Tyr Ser Thr Gly Val Asn Val Phe Gln Thr Gln Ala Gly Cys Leu 
625                 630                 635                 640 


Ile Gly Ala Glu His Val Asn Ala Ser Tyr Glu Cys Asp Ile Pro Ile 
                645                 650                 655     


Gly Ala Gly Ile Cys Ala Ser Tyr His Thr Ala Ser Val Leu Arg Ser 
            660                 665                 670         


Thr Gly Gln Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Glu 
        675                 680                 685             


Asn Ser Ile Ala Tyr Ala Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
    690                 695                 700                 


Ser Ile Ser Val Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr 
705                 710                 715                 720 


Ala Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Leu Glu Cys Ser 
                725                 730                 735     


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
            740                 745                 750         


Leu Thr Gly Ile Ala Ile Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
        755                 760                 765             


Ala Gln Val Lys Gln Met Tyr Lys Thr Pro Ala Ile Lys Asp Phe Gly 
    770                 775                 780                 


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Thr Lys 
785                 790                 795                 800 


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
                805                 810                 815     


Ala Gly Phe Met Lys Gln Tyr Gly Asp Cys Leu Gly Asp Val Ser Ala 
            820                 825                 830         


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
        835                 840                 845             


Pro Leu Leu Thr Asp Glu Met Val Ala Ala Tyr Thr Ala Ala Leu Val 
    850                 855                 860                 


Ser Gly Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
865                 870                 875                 880 


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
                885                 890                 895     


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
            900                 905                 910         


Phe Asn Ser Ala Ile Gly Lys Ile Gln Glu Ser Leu Ser Ser Thr Ala 
        915                 920                 925             


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
    930                 935                 940                 


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
945                 950                 955                 960 


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
                965                 970                 975     


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
            980                 985                 990         


Tyr Val Thr Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
        995                 1000                 1005             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1010                 1015                 1020             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1025                 1030                 1035             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1040                 1045                 1050             


Val Pro  Ser Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1055                 1060                 1065             


His Glu  Gly Lys Ala Tyr Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1070                 1075                 1080             


Asn Gly  Thr Ser Trp Phe Ile  Thr Gln Arg Asn Phe  Tyr Ser Pro 
    1085                 1090                 1095             


Gln Leu  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1100                 1105                 1110             


Val Val  Ile Gly Ile Ile Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1115                 1120                 1125             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1130                 1135                 1140             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1145                 1150                 1155             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1160                 1165                 1170             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1175                 1180                 1185             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro Trp  Tyr Val Trp 
    1190                 1195                 1200             


Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile Val Met  Val Thr Ile 
    1205                 1210                 1215             


Leu Leu  Cys Cys Met Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Ala 
    1220                 1225                 1230             


Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu 
    1235                 1240                 1245             


Pro Val  Leu Lys Gly Val Lys  Leu His Tyr Thr 
    1250                 1255                 


<210>  7
<211>  1242
<212>  PRT
<213>  Unknown

<220>
<223>  Bat CoV HKU3

<400>  7

Met Lys Ile Leu Ile Phe Ala Phe Leu Ala Asn Leu Ala Lys Ala Gln 
1               5                   10                  15      


Glu Gly Cys Gly Ile Ile Ser Arg Lys Pro Gln Pro Lys Met Ala Gln 
            20                  25                  30          


Val Ser Ser Ser Arg Arg Gly Val Tyr Tyr Asn Asp Asp Ile Phe Arg 
        35                  40                  45              


Ser Asp Val Leu His Leu Thr Gln Asp Tyr Phe Leu Pro Phe Asp Ser 
    50                  55                  60                  


Asn Leu Thr Gln Tyr Phe Ser Leu Asn Val Asp Ser Asp Arg Tyr Thr 
65                  70                  75                  80  


Tyr Phe Asp Asn Pro Ile Leu Asp Phe Gly Asp Gly Val Tyr Phe Ala 
                85                  90                  95      


Ala Thr Glu Lys Ser Asn Val Ile Arg Gly Trp Ile Phe Gly Ser Ser 
            100                 105                 110         


Phe Asp Asn Thr Thr Gln Ser Ala Val Ile Val Asn Asn Ser Thr His 
        115                 120                 125             


Ile Ile Ile Arg Val Cys Asn Phe Asn Leu Cys Lys Glu Pro Met Tyr 
    130                 135                 140                 


Thr Val Ser Arg Gly Thr Gln Gln Asn Ala Trp Val Tyr Gln Ser Ala 
145                 150                 155                 160 


Phe Asn Cys Thr Tyr Asp Arg Val Glu Lys Ser Phe Gln Leu Asp Thr 
                165                 170                 175     


Thr Pro Lys Thr Gly Asn Phe Lys Asp Leu Arg Glu Tyr Val Phe Lys 
            180                 185                 190         


Asn Arg Asp Gly Phe Leu Ser Val Tyr Gln Thr Tyr Thr Ala Val Asn 
        195                 200                 205             


Leu Pro Arg Gly Leu Pro Thr Gly Phe Ser Val Leu Lys Pro Ile Leu 
    210                 215                 220                 


Lys Leu Pro Phe Gly Ile Asn Ile Thr Ser Tyr Arg Val Val Met Ala 
225                 230                 235                 240 


Met Phe Ser Gln Thr Thr Ser Asn Phe Leu Pro Glu Ser Ala Ala Tyr 
                245                 250                 255     


Tyr Val Gly Asn Leu Lys Tyr Ser Thr Phe Met Leu Arg Phe Asn Glu 
            260                 265                 270         


Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala 
        275                 280                 285             


Glu Leu Lys Cys Thr Ile Lys Asn Phe Asn Val Asp Lys Gly Ile Tyr 
    290                 295                 300                 


Gln Thr Ser Asn Phe Arg Val Ser Pro Thr Gln Glu Val Ile Arg Phe 
305                 310                 315                 320 


Pro Asn Ile Thr Asn Arg Cys Pro Phe Asp Lys Val Phe Asn Ala Thr 
                325                 330                 335     


Arg Phe Pro Asn Val Tyr Ala Trp Glu Arg Thr Lys Ile Ser Asp Cys 
            340                 345                 350         


Val Ala Asp Tyr Thr Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe 
        355                 360                 365             


Lys Cys Tyr Gly Val Ser Pro Ser Lys Leu Ile Asp Leu Cys Phe Thr 
    370                 375                 380                 


Ser Val Tyr Ala Asp Thr Phe Leu Ile Arg Ser Ser Glu Val Arg Gln 
385                 390                 395                 400 


Val Ala Pro Gly Glu Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu 
                405                 410                 415     


Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Thr Ala Lys His 
            420                 425                 430         


Asp Thr Gly Asn Tyr Tyr Tyr Arg Ser His Arg Lys Thr Lys Leu Lys 
        435                 440                 445             


Pro Phe Glu Arg Asp Leu Ser Ser Asp Asp Gly Asn Gly Val Tyr Thr 
    450                 455                 460                 


Leu Ser Thr Tyr Asp Phe Asn Pro Asn Val Pro Val Ala Tyr Gln Ala 
465                 470                 475                 480 


Thr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
                485                 490                 495     


Val Cys Gly Pro Lys Leu Ser Thr Glu Leu Val Lys Asn Gln Cys Val 
            500                 505                 510         


Asn Phe Asn Phe Asn Gly Leu Lys Gly Thr Gly Val Leu Thr Ser Ser 
        515                 520                 525             


Ser Lys Arg Phe Gln Ser Phe Gln Gln Phe Gly Arg Asp Thr Ser Asp 
    530                 535                 540                 


Phe Thr Asp Ser Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
545                 550                 555                 560 


Ser Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
                565                 570                 575     


Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp 
            580                 585                 590         


Val Pro Thr Ala Ile Arg Ala Asp Gln Leu Thr Pro Ala Trp Arg Val 
        595                 600                 605             


Tyr Ser Thr Gly Val Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile 
    610                 615                 620                 


Gly Ala Glu His Val Asn Ala Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
625                 630                 635                 640 


Ala Gly Ile Cys Ala Ser Tyr His Thr Ala Ser Val Leu Arg Ser Thr 
                645                 650                 655     


Gly Gln Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
            660                 665                 670         


Ser Ile Ala Tyr Ala Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Ser 
        675                 680                 685             


Ile Ser Val Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ala 
    690                 695                 700                 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Leu Glu Cys Ser Asn 
705                 710                 715                 720 


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
                725                 730                 735     


Thr Gly Ile Ala Ile Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
            740                 745                 750         


Gln Val Lys Gln Met Tyr Lys Thr Pro Ala Ile Lys Asp Phe Gly Gly 
        755                 760                 765             


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Thr Lys Arg 
    770                 775                 780                 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
785                 790                 795                 800 


Gly Phe Met Lys Gln Tyr Gly Asp Cys Leu Gly Asp Val Ser Ala Arg 
                805                 810                 815     


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
            820                 825                 830         


Leu Leu Thr Asp Glu Met Val Ala Ala Tyr Thr Ala Ala Leu Val Ser 
        835                 840                 845             


Gly Thr Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
    850                 855                 860                 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
865                 870                 875                 880 


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
                885                 890                 895     


Asn Ser Ala Ile Gly Lys Ile Gln Glu Ser Leu Ser Ser Thr Ala Ser 
            900                 905                 910         


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
        915                 920                 925             


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
    930                 935                 940                 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
945                 950                 955                 960 


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
                965                 970                 975     


Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
            980                 985                 990         


Leu Ala Ala Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
        995                 1000                 1005             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1010                 1015                 1020             


Ser Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1025                 1030                 1035             


Ser Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Glu 
    1040                 1045                 1050             


Gly Lys  Ala Tyr Phe Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly 
    1055                 1060                 1065             


Thr Ser  Trp Phe Ile Thr Gln  Arg Asn Phe Tyr Ser  Pro Gln Leu 
    1070                 1075                 1080             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1085                 1090                 1095             


Ile Gly  Ile Ile Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1100                 1105                 1110             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1115                 1120                 1125             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1130                 1135                 1140             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1145                 1150                 1155             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1160                 1165                 1170             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Val  Trp Leu Gly 
    1175                 1180                 1185             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Leu Leu 
    1190                 1195                 1200             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Ala Cys Ser 
    1205                 1210                 1215             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1220                 1225                 1230             


Leu Lys  Gly Val Lys Leu His  Tyr Thr 
    1235                 1240         


<210>  8
<211>  1256
<212>  PRT
<213>  Unknown

<220>
<223>  Bat CoV SHC014

<400>  8

Met Lys Leu Leu Val Leu Val Phe Ala Thr Leu Val Ser Ser Tyr Thr 
1               5                   10                  15      


Ile Glu Lys Cys Leu Asp Phe Asp Asp Arg Thr Pro Pro Ala Asn Thr 
            20                  25                  30          


Gln Phe Leu Ser Ser His Arg Gly Val Tyr Tyr Pro Asp Asp Ile Phe 
        35                  40                  45              


Arg Ser Asn Val Leu His Leu Val Gln Asp His Phe Leu Pro Phe Asp 
    50                  55                  60                  


Ser Asn Val Thr Arg Phe Ile Thr Phe Gly Leu Asn Phe Asp Asn Pro 
65                  70                  75                  80  


Ile Ile Pro Phe Arg Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser 
                85                  90                  95      


Asn Val Ile Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser 
            100                 105                 110         


Gln Ser Val Ile Ile Met Asn Asn Ser Thr Asn Leu Val Ile Arg Ala 
        115                 120                 125             


Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Val Val Leu Lys Ser 
    130                 135                 140                 


Asn Asn Thr Gln Ile Pro Ser Tyr Ile Phe Asn Asn Ala Phe Asn Cys 
145                 150                 155                 160 


Thr Phe Glu Tyr Val Ser Lys Asp Phe Asn Leu Asp Leu Gly Glu Lys 
                165                 170                 175     


Pro Gly Asn Phe Lys Asp Leu Arg Glu Phe Val Phe Arg Asn Lys Asp 
            180                 185                 190         


Gly Phe Leu His Val Tyr Ser Gly Tyr Gln Pro Ile Ser Ala Ala Ser 
        195                 200                 205             


Gly Leu Pro Thr Gly Phe Asn Ala Leu Lys Pro Ile Phe Lys Leu Pro 
    210                 215                 220                 


Leu Gly Ile Asn Ile Thr Asn Phe Arg Thr Leu Leu Thr Ala Phe Pro 
225                 230                 235                 240 


Pro Arg Pro Asp Tyr Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly 
                245                 250                 255     


Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys 
        275                 280                 285             


Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Ala Pro Ser Lys Glu Val Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Thr Phe Pro 
                325                 330                 335     


Ser Val Tyr Ala Trp Glu Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Thr Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Leu Gly Cys Val Leu Ala Trp Asn Thr Asn Ser Lys Asp Ser Ser 
            420                 425                 430         


Thr Ser Gly Asn Tyr Asn Tyr Leu Tyr Arg Trp Val Arg Arg Ser Lys 
        435                 440                 445             


Leu Asn Pro Tyr Glu Arg Asp Leu Ser Asn Asp Ile Tyr Ser Pro Gly 
    450                 455                 460                 


Gly Gln Ser Cys Ser Ala Val Gly Pro Asn Cys Tyr Asn Pro Leu Arg 
465                 470                 475                 480 


Pro Tyr Gly Phe Phe Thr Thr Ala Gly Val Gly His Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys 
    530                 535                 540                 


Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr 
545                 550                 555                 560 


Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Ser Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr His Thr Val Ser Ser Leu Arg Ser Thr Ser Gln 
            660                 665                 670         


Lys Ser Ile Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile 
        675                 680                 685             


Ala Tyr Ser Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser 
    690                 695                 700                 


Ile Thr Thr Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp 
705                 710                 715                 720 


Cys Asn Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu 
                725                 730                 735     


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly 
            740                 745                 750         


Ile Ala Val Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val 
        755                 760                 765             


Lys Gln Met Tyr Lys Thr Pro Thr Leu Lys Asp Phe Gly Gly Phe Asn 
    770                 775                 780                 


Phe Ser Gln Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe 
785                 790                 795                 800 


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
                805                 810                 815     


Met Lys Gln Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu 
            820                 825                 830         


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
        835                 840                 845             


Thr Asp Asp Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr 
    850                 855                 860                 


Ala Thr Ala Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
865                 870                 875                 880 


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
                885                 890                 895     


Asn Val Leu Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys 
            900                 905                 910         


Ala Ile Ser Gln Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu 
        915                 920                 925             


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
    930                 935                 940                 


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
945                 950                 955                 960 


Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile 
                965                 970                 975     


Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr 
            980                 985                 990         


Gln Gln Leu Ile Arg Ala Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala 
        995                 1000                 1005             


Ala Thr  Lys Met Ser Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val 
    1010                 1015                 1020             


Asp Phe  Cys Gly Lys Gly Tyr  His Leu Met Ser Phe  Pro Gln Ala 
    1025                 1030                 1035             


Ala Pro  His Gly Val Val Phe  Leu His Val Thr Tyr  Val Pro Ser 
    1040                 1045                 1050             


Gln Glu  Arg Asn Phe Thr Thr  Ala Pro Ala Ile Cys  His Glu Gly 
    1055                 1060                 1065             


Lys Ala  Tyr Phe Pro Arg Glu  Gly Val Phe Val Phe  Asn Gly Thr 
    1070                 1075                 1080             


Ser Trp  Phe Ile Thr Gln Arg  Asn Phe Phe Ser Pro  Gln Ile Ile 
    1085                 1090                 1095             


Thr Thr  Asp Asn Thr Phe Val  Ser Gly Ser Cys Asp  Val Val Ile 
    1100                 1105                 1110             


Gly Ile  Ile Asn Asn Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu 
    1115                 1120                 1125             


Asp Ser  Phe Lys Glu Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr 
    1130                 1135                 1140             


Ser Pro  Asp Val Asp Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser 
    1145                 1150                 1155             


Val Val  Asn Ile Gln Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala 
    1160                 1165                 1170             


Lys Asn  Leu Asn Glu Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys 
    1175                 1180                 1185             


Tyr Glu  Gln Tyr Ile Lys Trp  Pro Trp Tyr Val Trp  Leu Gly Phe 
    1190                 1195                 1200             


Ile Ala  Gly Leu Ile Ala Ile  Val Met Val Thr Ile  Leu Leu Cys 
    1205                 1210                 1215             


Cys Met  Thr Ser Cys Cys Ser  Cys Leu Lys Gly Ala  Cys Ser Cys 
    1220                 1225                 1230             


Gly Ser  Cys Cys Lys Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu 
    1235                 1240                 1245             


Lys Gly  Val Lys Leu His Tyr  Thr 
    1250                 1255     


<210>  9
<211>  1269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimera 1 HKU3-1 NTD/SARS-COV RBD/SARS-CoV-2 S2

<400>  9

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Gly Ile Ile Ser Arg Lys Pro 
            20                  25                  30          


Gln Pro Lys Met Ala Gln Val Ser Ser Ser Arg Arg Gly Val Tyr Tyr 
        35                  40                  45              


Asn Asp Asp Ile Phe Arg Ser Asp Val Leu His Leu Thr Gln Asp Tyr 
    50                  55                  60                  


Phe Leu Pro Phe Asp Ser Asn Leu Thr Gln Tyr Phe Ser Leu Asn Val 
65                  70                  75                  80  


Asp Ser Asp Arg Tyr Thr Tyr Phe Asp Asn Pro Ile Leu Asp Phe Gly 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Ser Ser Phe Asp Asn Thr Thr Gln Ser Ala Val Ile 
        115                 120                 125             


Val Asn Asn Ser Thr His Ile Ile Ile Arg Val Cys Asn Phe Asn Leu 
    130                 135                 140                 


Cys Lys Glu Pro Met Tyr Thr Val Ser Arg Gly Thr Gln Gln Asn Ala 
145                 150                 155                 160 


Trp Val Tyr Gln Ser Ala Phe Asn Cys Thr Tyr Asp Arg Val Glu Lys 
                165                 170                 175     


Ser Phe Gln Leu Asp Thr Thr Pro Lys Thr Gly Asn Phe Lys Asp Leu 
            180                 185                 190         


Arg Glu Tyr Val Phe Lys Asn Arg Asp Gly Phe Leu Ser Val Tyr Gln 
        195                 200                 205             


Thr Tyr Thr Ala Val Asn Leu Pro Arg Gly Leu Pro Thr Gly Phe Ser 
    210                 215                 220                 


Val Leu Lys Pro Ile Leu Lys Leu Pro Phe Gly Ile Asn Ile Thr Ser 
225                 230                 235                 240 


Tyr Arg Val Val Met Ala Met Phe Ser Gln Thr Thr Ser Asn Phe Leu 
                245                 250                 255     


Pro Glu Ser Ala Ala Tyr Tyr Val Gly Asn Leu Lys Tyr Ser Thr Phe 
            260                 265                 270         


Met Leu Arg Phe Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys Thr Ile Lys Asn Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg 
            340                 345                 350         


Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys 
385                 390                 395                 400 


Gly Asp Asp Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala 
            420                 425                 430         


Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Asn Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro 
465                 470                 475                 480 


Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr 
                485                 490                 495     


Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
            500                 505                 510         


Leu Leu Asn Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
        515                 520                 525             


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
    530                 535                 540                 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
545                 550                 555                 560 


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
                565                 570                 575     


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
            580                 585                 590         


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
        595                 600                 605             


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
    610                 615                 620                 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
625                 630                 635                 640 


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
                645                 650                 655     


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
            660                 665                 670         


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
        675                 680                 685             


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
    690                 695                 700                 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
705                 710                 715                 720 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
                725                 730                 735     


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
            740                 745                 750         


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
        755                 760                 765             


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
    770                 775                 780                 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
785                 790                 795                 800 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
                805                 810                 815     


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
            820                 825                 830         


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
        835                 840                 845             


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
    850                 855                 860                 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
865                 870                 875                 880 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
                885                 890                 895     


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
            900                 905                 910         


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
        915                 920                 925             


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
    930                 935                 940                 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
945                 950                 955                 960 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
                965                 970                 975     


Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu 
            980                 985                 990         


Ile Thr Gly Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
        995                 1000                 1005             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
    1010                 1015                 1020             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1025                 1030                 1035             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1040                 1045                 1050             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1055                 1060                 1065             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1070                 1075                 1080             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1085                 1090                 1095             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1100                 1105                 1110             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1115                 1120                 1125             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1130                 1135                 1140             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1145                 1150                 1155             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1160                 1165                 1170             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1175                 1180                 1185             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1190                 1195                 1200             


Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala 
    1205                 1210                 1215             


Gly Leu  Ile Ala Ile Val Met  Val Thr Ile Met Leu  Cys Cys Met 
    1220                 1225                 1230             


Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser 
    1235                 1240                 1245             


Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly 
    1250                 1255                 1260             


Val Lys  Leu His Tyr Thr 
    1265                 


<210>  10
<211>  1268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimera 2 SARS-CoV-2 RBD/SARS-CoV NTD and S2

<400>  10

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Ser Asp Leu Asp Arg Cys Thr 
            20                  25                  30          


Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln His Thr Ser Ser 
        35                  40                  45              


Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg Ser Asp Thr Leu 
    50                  55                  60                  


Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser Asn Val Thr Gly 
65                  70                  75                  80  


Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val Ile Pro Phe Lys 
                85                  90                  95      


Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn Val Val Arg Gly 
            100                 105                 110         


Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln Ser Val Ile Ile 
        115                 120                 125             


Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys Asn Phe Glu Leu 
    130                 135                 140                 


Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met Gly Thr Gln Thr 
145                 150                 155                 160 


His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr Phe Glu Tyr Ile 
                165                 170                 175     


Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser Gly Asn Phe Lys 
            180                 185                 190         


His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly Phe Leu Tyr Val 
        195                 200                 205             


Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp Leu Pro Ser Gly 
    210                 215                 220                 


Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu Gly Ile Asn Ile 
225                 230                 235                 240 


Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro Ala Gln Asp Ile 
                245                 250                 255     


Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr Leu Lys Pro Thr 
            260                 265                 270         


Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile Thr Asp Ala Val 
        275                 280                 285             


Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys Ser Val Lys Ser 
    290                 295                 300                 


Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Val 
305                 310                 315                 320 


Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
                325                 330                 335     


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
            340                 345                 350         


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
        355                 360                 365             


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
    370                 375                 380                 


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
385                 390                 395                 400 


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
                405                 410                 415     


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
            420                 425                 430         


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
        435                 440                 445             


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
    450                 455                 460                 


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
465                 470                 475                 480 


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
                485                 490                 495     


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
            500                 505                 510         


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Leu 
        515                 520                 525             


Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn Phe Asn Gly 
    530                 535                 540                 


Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro 
545                 550                 555                 560 


Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser Val Arg 
                565                 570                 575     


Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly 
            580                 585                 590         


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser Glu Val Ala 
        595                 600                 605             


Val Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr Ala Ile His 
    610                 615                 620                 


Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn 
625                 630                 635                 640 


Val Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp 
                645                 650                 655     


Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            660                 665                 670         


Tyr His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys Ser Ile Val 
        675                 680                 685             


Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn 
    690                 695                 700                 


Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu 
705                 710                 715                 720 


Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met Tyr 
                725                 730                 735     


Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly 
            740                 745                 750         


Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu 
        755                 760                 765             


Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met Tyr 
    770                 775                 780                 


Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile 
785                 790                 795                 800 


Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu 
                805                 810                 815     


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr 
            820                 825                 830         


Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln 
        835                 840                 845             


Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met 
    850                 855                 860                 


Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly 
865                 870                 875                 880 


Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln 
                885                 890                 895     


Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr 
            900                 905                 910         


Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln 
        915                 920                 925             


Ile Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln 
    930                 935                 940                 


Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln 
945                 950                 955                 960 


Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu 
                965                 970                 975     


Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile 
            980                 985                 990         


Thr Gly Arg Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
        995                 1000                 1005             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1010                 1015                 1020             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1025                 1030                 1035             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ala  Ala Pro His 
    1040                 1045                 1050             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ser  Gln Glu Arg 
    1055                 1060                 1065             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Glu Gly  Lys Ala Tyr 
    1070                 1075                 1080             


Phe Pro  Arg Glu Gly Val Phe  Val Phe Asn Gly Thr  Ser Trp Phe 
    1085                 1090                 1095             


Ile Thr  Gln Arg Asn Phe Phe  Ser Pro Gln Ile Ile  Thr Thr Asp 
    1100                 1105                 1110             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Ile 
    1115                 1120                 1125             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1130                 1135                 1140             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1145                 1150                 1155             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1160                 1165                 1170             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1175                 1180                 1185             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1190                 1195                 1200             


Tyr Ile  Lys Trp Pro Trp Tyr  Val Trp Leu Gly Phe  Ile Ala Gly 
    1205                 1210                 1215             


Leu Ile  Ala Ile Val Met Val  Thr Ile Leu Leu Cys  Cys Met Thr 
    1220                 1225                 1230             


Ser Cys  Cys Ser Cys Leu Lys  Gly Ala Cys Ser Cys  Gly Ser Cys 
    1235                 1240                 1245             


Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro Val Leu  Lys Gly Val 
    1250                 1255                 1260             


Lys Leu  His Tyr Thr 
    1265             


<210>  11
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimera 3 SARS-CoV RBD/SARS-CoV-2 NTD and S2

<400>  11

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Val Asn Leu Thr Thr Arg Thr 
            20                  25                  30          


Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
        35                  40                  45              


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
    50                  55                  60                  


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
65                  70                  75                  80  


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
                85                  90                  95      


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
            100                 105                 110         


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
        115                 120                 125             


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
    130                 135                 140                 


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
145                 150                 155                 160 


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
                165                 170                 175     


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
            180                 185                 190         


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
        195                 200                 205             


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
    210                 215                 220                 


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
225                 230                 235                 240 


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
                245                 250                 255     


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
            260                 265                 270         


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
        275                 280                 285             


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
    290                 295                 300                 


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
305                 310                 315                 320 


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
                325                 330                 335     


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            340                 345                 350         


Asn Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile 
        355                 360                 365             


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe 
    370                 375                 380                 


Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu 
385                 390                 395                 400 


Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp 
                405                 410                 415     


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn 
            420                 425                 430         


Tyr Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr 
        435                 440                 445             


Arg Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg 
    450                 455                 460                 


Tyr Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn 
465                 470                 475                 480 


Val Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn 
                485                 490                 495     


Cys Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Lys Val Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser 
    1235                 1240                 1245             


Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys 
    1250                 1255                 1260             


Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys 
    1265                 1270                 1275             


Leu His  Tyr Thr 
    1280         


<210>  12
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimera 4 RsSHC014 RBD/Remaining Spike SARS-CoV-2

<400>  12

Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val 
1               5                   10                  15      


Leu Met Ser Ala Gln Glu Ser Trp Ala Val Asn Leu Thr Thr Arg Thr 
            20                  25                  30          


Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
        35                  40                  45              


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
    50                  55                  60                  


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
65                  70                  75                  80  


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
                85                  90                  95      


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
            100                 105                 110         


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
        115                 120                 125             


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
    130                 135                 140                 


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
145                 150                 155                 160 


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
                165                 170                 175     


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
            180                 185                 190         


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
        195                 200                 205             


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
    210                 215                 220                 


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
225                 230                 235                 240 


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
                245                 250                 255     


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
            260                 265                 270         


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
        275                 280                 285             


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
    290                 295                 300                 


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
305                 310                 315                 320 


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
                325                 330                 335     


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
            340                 345                 350         


Asn Ala Thr Thr Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Arg Ile 
        355                 360                 365             


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Ser Phe 
    370                 375                 380                 


Ser Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu 
385                 390                 395                 400 


Cys Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp 
                405                 410                 415     


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn 
            420                 425                 430         


Tyr Lys Leu Pro Asp Asp Phe Leu Gly Cys Val Leu Ala Trp Asn Thr 
        435                 440                 445             


Asn Ser Lys Asp Ser Ser Thr Ser Gly Asn Tyr Asn Tyr Leu Tyr Arg 
    450                 455                 460                 


Trp Val Arg Arg Ser Lys Leu Asn Pro Tyr Glu Arg Asp Leu Ser Asn 
465                 470                 475                 480 


Asp Ile Tyr Ser Pro Gly Gly Gln Ser Cys Ser Ala Val Gly Pro Asn 
                485                 490                 495     


Cys Tyr Asn Pro Leu Arg Pro Tyr Gly Phe Phe Thr Thr Ala Gly Val 
            500                 505                 510         


Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Lys Val Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser 
    1235                 1240                 1245             


Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys 
    1250                 1255                 1260             


Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys 
    1265                 1270                 1275             


Leu His  Tyr Thr 
    1280         


