                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
 
<120>  REDIRECTING GLUCOSE METABOLISM TO LIMIT STRESS AND IMPROVE 
       ADOPTIVE CELL THERAPY

<130>  8123-104998-02

<150>  63/106,340
<151>  2020-10-27

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  2672
<212>  DNA
<213>  Homo sapiens

<400>  1
gaaacctggc gtactggctg tggcttctct agcgggactc ggcatgaggc tggcgcggct       60

gcttcgcgga gccgccttgg ccggcccggg cccggggctg cgcgccgccg gcttcagccg      120

cagcttcagc tcggactcgg gctccagccc ggcgtccgag cgcggcgttc cgggccaggt      180

ggacttctac gcgcgcttct cgccgtcccc gctctccatg aagcagttcc tggacttcgg      240

atcagtgaat gcttgtgaaa agacctcatt tatgtttctg cggcaagagt tgcctgtcag      300

actggcaaat ataatgaaag aaataagtct ccttccagat aatcttctca ggacaccatc      360

cgttcaattg gtacaaagct ggtatatcca gagtcttcag gagcttcttg attttaagga      420

caaaagtgct gaggatgcta aagctattta tgactttaca gatactgtga tacggatcag      480

aaaccgacac aatgatgtca ttcccacaat ggcccagggt gtgattgaat acaaggagag      540

ctttggggtg gatcctgtca ccagccagaa tgttcagtac tttttggatc gattctacat      600

gagtcgcatt tcaattagaa tgttactcaa tcagcactct ttattgtttg gtggaaaagg      660

caaaggaagt ccatctcatc gaaaacacat tggaagcata aatccaaact gcaatgtact      720

tgaagttatt aaagatggct atgaaaatgc taggcgtctg tgtgatttgt attatattaa      780

ctctcccgaa ctagaacttg aagaactaaa tgcaaaatca ccaggacagc caatacaagt      840

ggtttatgta ccatcccatc tctatcacat ggtgtttgaa cttttcaaga atgcaatgag      900

agccactatg gaacaccatg ccaacagagg tgtttacccc cctattcaag ttcatgtcac      960

gctgggtaat gaggatttga ctgtgaagat gagtgaccga ggaggtggcg ttcctttgag     1020

gaaaattgac agacttttca actacatgta ttcaactgca ccaagacctc gtgttgagac     1080

ctcccgcgca gtgcctctgg ctggttttgg ttatggattg cccatatcac gtctttacgc     1140

acaatacttc caaggagacc tgaagctgta ttccctagag ggttacggga cagatgcagt     1200

tatctacatt aaggctctgt caacagactc aatagaaaga ctcccagtgt ataacaaagc     1260

tgcctggaag cattacaaca ccaaccacga ggctgatgac tggtgcgtcc ccagcagaga     1320

acccaaagac atgacgacgt tccgcagtgc ctagacacac ttgggacatc ggaaaatcca     1380

aatgtggctt ttgtattaaa tttggaagtg tggcccagag ttgctcagaa ttggagcaga     1440

gcctgagacg tatctgcaga tcctgtcatc agctggcaag tccaggagac tgtgtcattt     1500

agagactgtg ttgttagtta tccctcaaca tcttctaagg tggcaggaaa taatattgga     1560

aataacattt taaagtaaaa attttaaagt ttaaagaaga gttttgccac ttaaacaggg     1620

gagctttgtc tggaaaatac actgagttga aacacttcat ccttggaagg attatataag     1680

atgaacagtt gtgataaatg tgtagattag agggatgtga atgggcagtt agtccagtgc     1740

cctcatttaa gaggccaaga tcctgattca gaggaggcat cctttgccca gagctgctta     1800

gctaatctga ccaaatgttg ggaaaaatgt ctcacctaac ccactattcc ttaattatgg     1860

attttgtgaa aaacaataga acatgttaat gagtaattta tattagttcg atgtattaca     1920

attttttagc tttaaattac agttttctta taatgttgaa atgttttaga atcctttgaa     1980

tctaagtatt tgtttcctaa atgaaacatt tgtacaacat ttgatgtttt tacttatgaa     2040

atattctcct cccccaagaa aatttaaact ttttctctct atttaaaagc taagaaatgt     2100

tttaaaggaa aaatgaaatt atcttccttt agcttatttt taaggtaaaa cagcttttta     2160

ctctgttatt gtggtaatgg acagaatatt acatacaaaa atattctggg agagcttttt     2220

cctagttggt tttaaatcat tgtgccacct gaaaggtttt tagattttat aggagctaat     2280

ttgtccacca gcattaatgt aacacagtgt agttatgaaa atatattgaa ggacaggaag     2340

tggacacgaa gtgatttttg taacctgagc agttaatgaa tgtgccaaca ttttctagga     2400

agggacagca agaatattct gctctgtagt taaaatactg gctggctttt gatgtcttca     2460

tgcttaattg tgatcacttt cttgcactgt gatgttttta cgtgaatatg ttgaagtaga     2520

agtctaccat attattttat aaaatgtttt ctgtatggca ataaactgaa aacatggatc     2580

aacccttctt ttgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2640

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                   2672


<210>  2
<211>  436
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Leu Ala Arg Leu Leu Arg Gly Ala Ala Leu Ala Gly Pro Gly 
1               5                   10                  15      


Pro Gly Leu Arg Ala Ala Gly Phe Ser Arg Ser Phe Ser Ser Asp Ser 
            20                  25                  30          


Gly Ser Ser Pro Ala Ser Glu Arg Gly Val Pro Gly Gln Val Asp Phe 
        35                  40                  45              


Tyr Ala Arg Phe Ser Pro Ser Pro Leu Ser Met Lys Gln Phe Leu Asp 
    50                  55                  60                  


Phe Gly Ser Val Asn Ala Cys Glu Lys Thr Ser Phe Met Phe Leu Arg 
65                  70                  75                  80  


Gln Glu Leu Pro Val Arg Leu Ala Asn Ile Met Lys Glu Ile Ser Leu 
                85                  90                  95      


Leu Pro Asp Asn Leu Leu Arg Thr Pro Ser Val Gln Leu Val Gln Ser 
            100                 105                 110         


Trp Tyr Ile Gln Ser Leu Gln Glu Leu Leu Asp Phe Lys Asp Lys Ser 
        115                 120                 125             


Ala Glu Asp Ala Lys Ala Ile Tyr Asp Phe Thr Asp Thr Val Ile Arg 
    130                 135                 140                 


Ile Arg Asn Arg His Asn Asp Val Ile Pro Thr Met Ala Gln Gly Val 
145                 150                 155                 160 


Ile Glu Tyr Lys Glu Ser Phe Gly Val Asp Pro Val Thr Ser Gln Asn 
                165                 170                 175     


Val Gln Tyr Phe Leu Asp Arg Phe Tyr Met Ser Arg Ile Ser Ile Arg 
            180                 185                 190         


Met Leu Leu Asn Gln His Ser Leu Leu Phe Gly Gly Lys Gly Lys Gly 
        195                 200                 205             


Ser Pro Ser His Arg Lys His Ile Gly Ser Ile Asn Pro Asn Cys Asn 
    210                 215                 220                 


Val Leu Glu Val Ile Lys Asp Gly Tyr Glu Asn Ala Arg Arg Leu Cys 
225                 230                 235                 240 


Asp Leu Tyr Tyr Ile Asn Ser Pro Glu Leu Glu Leu Glu Glu Leu Asn 
                245                 250                 255     


Ala Lys Ser Pro Gly Gln Pro Ile Gln Val Val Tyr Val Pro Ser His 
            260                 265                 270         


Leu Tyr His Met Val Phe Glu Leu Phe Lys Asn Ala Met Arg Ala Thr 
        275                 280                 285             


Met Glu His His Ala Asn Arg Gly Val Tyr Pro Pro Ile Gln Val His 
    290                 295                 300                 


Val Thr Leu Gly Asn Glu Asp Leu Thr Val Lys Met Ser Asp Arg Gly 
305                 310                 315                 320 


Gly Gly Val Pro Leu Arg Lys Ile Asp Arg Leu Phe Asn Tyr Met Tyr 
                325                 330                 335     


Ser Thr Ala Pro Arg Pro Arg Val Glu Thr Ser Arg Ala Val Pro Leu 
            340                 345                 350         


Ala Gly Phe Gly Tyr Gly Leu Pro Ile Ser Arg Leu Tyr Ala Gln Tyr 
        355                 360                 365             


Phe Gln Gly Asp Leu Lys Leu Tyr Ser Leu Glu Gly Tyr Gly Thr Asp 
    370                 375                 380                 


Ala Val Ile Tyr Ile Lys Ala Leu Ser Thr Asp Ser Ile Glu Arg Leu 
385                 390                 395                 400 


Pro Val Tyr Asn Lys Ala Ala Trp Lys His Tyr Asn Thr Asn His Glu 
                405                 410                 415     


Ala Asp Asp Trp Cys Val Pro Ser Arg Glu Pro Lys Asp Met Thr Thr 
            420                 425                 430         


Phe Arg Ser Ala 
        435     


<210>  3
<211>  9146
<212>  DNA
<213>  Homo sapiens

<400>  3
ggcggccccg cacggtaggg gagcagagtg ggcaggccgg gggtgagggc tcgcgctccg       60

ggagctgcac ggggctgcgt ggaaagagcg ccgagcggtg gcgtcgttgt cgccccctcc      120

tcgtcgggaa gaatcgtttg gtctcctgcc gtgcccggtt cgtattccct actccctgcc      180

acgagccgcc ccgtccggga tcctccaccc gtccaaagtt gtgagggggc gccgggcgtg      240

ctcgcggatc ggcggccgcg ggcgtgcgga gggctggacg agccctggag cgccaggtgc      300

gcgccgggcg tccgggctgt ggggcgggcg tggcggcgct gggggccgtc ggggggctgg      360

gggcgggggc gggggcgccg tgcagcccta gcgtcttccg gcccctgcgc tccagctgtc      420

agcacgaagg gcgccgcggg gccggcggca gagtgagctc cagggaggct gtagggctgc      480

ggcactgcct gagggtctcc ctgacgcacc ccgggtcagg gctggccccg ctggcagcct      540

gacaccggcc ggcccctgtt cgtctggact gaaacgggca cccctggggc ggggccgggc      600

cgggcagggc ggggcgggca gcgggcgggg ctgcagtcca tgggcttcgc gccccggctg      660

gatggagggg ctggccctcg gggcgcaccc ctgctcgcgc ctgggccccg ctgccttggg      720

ctgtggcttt gcctccccgg cggggtgggt tggtttggtt ggcttccttg ttctctccac      780

ccctttatcc ctcctccatc ctcttccccc ccacctccca gcccattcac cgggctggag      840

cgagacctcg cccctcctcc gctcccgcct ccccgccgcc gcctcctcta atgagcatct      900

ctgccttgct ttcaatgggc cggtgctgct gtcgctgctg ctgcccgcgc gggttgtgga      960

tgttgtcggc tccgtgttgt gatgacagga gaatgtgtgt gtgtcccggg cccagacgaa     1020

ttggtaggta ttcacttaac tacctgcgtt gggtacccag gaaggatggt gacagatttt     1080

tgtgtatgga tggttttaga tgaatcagcg tggtattaag ggatgagata gattggaaaa     1140

agggacaaac gcgtcttgga ttgagatagc tttgatgtct ttgtgagtgc agtttttcag     1200

gtagcgacaa aggaaactaa tcaaaaaaat actggcgtgt ggtgcttcgt atctttcttc     1260

atttatgtaa aaagatagca ggagctgtga aatggctagg catttccaga aaaatgttga     1320

aaaatcgcgg atggtcttta tgtagagtgt ttaatgcaat cggattacat aaactggggt     1380

tccgacacat taaatgatta gcatagcttt tctttttcat ttacatcaga agctttgcaa     1440

agctaaaggg ctctggagtc ggtgccttaa tagcatttgc taattaattt ggtccgtggg     1500

tctattgatg gagtggaaaa aatgtcttgg cacaggctct gctaagcaca tcagtaagaa     1560

tggacggctc tctttcctgt ttctggttgc agtgcatctt tctttattag tcattggcaa     1620

aatcagccca atctgcctgg gatgaagatg ctacatacaa cgtggctgag tctagatcat     1680

ggaataggaa attttccgtg aaaattgtga tcaagaataa cttgcaaatt tgacactgct     1740

ctgttttacc aacagttgta cctggatgct gttcttattg cctgatcaag agccttctac     1800

actaatttaa caagcttgtc agcaaaagtt atgatgtaga gtgttttctt gttgttgaat     1860

cagtggataa tctgaaggat attaagagtt tttcattgct tacttattta tgaaagcatt     1920

tgaaagtact ttgactccca agggtatctg atctgatgga gagaatgtat cacttgtacc     1980

gatgcggata gaacgctcat taattacagc acagttttca taaattccaa cttccctagg     2040

aattttgtct tttgaaggca tgttggaagt tggggcatta ggatataatc tcagtccatg     2100

tactaagcct ctgcataact gaaagataga gtcaataaaa ttcactctct cattttttgt     2160

ttttaatctc aagaattttt gccttgaagg aaaaatgtag tggagaattt gatgtttgaa     2220

cgtaagtatt gttaaaagca cctgctgtgt caatcattgc tttttgtcac tagatttcat     2280

tcattttgca gtcaattaca aaagtagaaa agatgtcata ccaagccggg tgcagtggct     2340

catgcctgta atcccagcac tttgggaggc tgaggcgggt ggatggcctg aggtcaggag     2400

ttcgagacca acctgaccaa catggtgaaa ccccatctct actgaaaata cagaattagc     2460

cgggcaggag aatcgcttga accagggagg cggaggttgc gatgagctga gatcacgcca     2520

ttgcacttca gcctgggcaa caagagcaaa attcctcccc ccgctgccct ccctcccccc     2580

ccccggcaaa aaaatgtcga agcaaaggaa tttaaggaaa gtgcaggttt ccaggacttg     2640

ttattcctta attaaacaat caaaccctgt tatgcatcta tcaaccctcc ctccccccca     2700

cacaaatagt attttgagtc agtttacgtt ccatacaggc acattttcat tgtttttttc     2760

tgtaagattc ttaagtttta aagaaagagc aaatgcagtc ataaaattat gaagaaaaat     2820

tcattaagat tacattagtt tacattttta atgatagaaa acctttattc aaagcacaaa     2880

atgagttgat atgctttctg cacgcaaacc taaaaagaga tatggtttaa gtatggaagc     2940

cactgtcatg tggcccaaca tttgagcaca tcttctggct cagtcatgta cacttaacct     3000

ctggatgact ttcaggtatt cagtttgaat ttcttttatt taaatggtta ctcctgatgg     3060

attcccgttt ttctggaatt tctgtttttc attagtgcat ttcagaatgc ttttttagtt     3120

acggattctt atttccaaaa ttttagccat tactttctat tgcctgatct tgtcttcatt     3180

ttcgtaaaca aatcccttct tagatagtgc agttaaaatg atggtacttt ctactacttg     3240

cagaagagaa tctgtgtggc tggcttatgc agtgcttatt acagaaacaa acaagaatca     3300

gtgattattc agtgtttagt tttctttgct tccctctacc ccaatttatt actttttctc     3360

aaattattct tcaaaaaagg tacatgaaaa taatatatgg ctgacacatg ctatgatatt     3420

tgtttagccg tgggaaggaa tagttgctat taactcagat ggttttattt tctgtgttcc     3480

tttttgttta ttgcatttgt ttatttaaag tatttccaaa gtgtttcttt atagtacaaa     3540

tgactatttt gaagcagtat ctcaagaatt cagggaaaat atatgttatt gaggaagaag     3600

agggattttt tttcttgccc aaattatcta gattaatgat atattcatta aatttcccaa     3660

ataaatgccc agaaattatt ttcagcgcac atagtgagtg ataggatttt ttttaagttt     3720

gtaattatat tgctgtacct tttcaatcca aaccttagac tattatttga ctatactgct     3780

tccctggagc aagtaaatac cttttttttt tttttttaat gtgagagaaa acatttttgg     3840

tcttttaaaa tttattttta atttacaatt gacacataat attatatatt tatggggtac     3900

aatgtgatgt ttcagtgcat gtatatattg gtagacattg tgtaatgatc aaatcagagt     3960

gattaccata tccaagaaaa catttttcta ggggttaatt ctactttgga tccatagtag     4020

atgaaaatac ttctatgggt tttccttata gctgctaagc agggaacatt gttagtaggt     4080

aaattaagtt ctaggactga aaccatttat gttactaaca aagctttaga gctactgcaa     4140

tacttaaact tttttttttt ttttaatcat gaagggcacg gtagaattca acagtgaata     4200

aatgaaacct gaattttatt taaaaacctc acttccataa gcataaaggc atgaatccta     4260

gaagagcctt agatagcatc tgctctgttg atgttccttt acaggttaga agagtgagac     4320

tcaaagatgt gagctgactt ttccaagatt atttgggagt tggtggcaga cctatgcccg     4380

ttagcctggc aaattgccac agtggactag agaagcaagt tttgcaagac catctactgg     4440

ggtacaggag agaaatactg gaatttcttt ttttatttaa ttatgtagaa atttttctat     4500

atatgttaca atgcatatta ctgtagtcat atatgtatat gatgtacacg taattcataa     4560

atacacatat gtttggctgc ctcttaacat ttttggtcat agccatgtgt aatcatgcca     4620

aaaattgacc acaggtctat gtaaagggtc ttcataaatg gaagaagtcc ctgtgtaaaa     4680

tgggagattt caaggcattt tttaagaata gggagggaga aggatgattg gtcaggtaga     4740

cggctactgc ataatgttat ataaccttca tctcctcagc tttccccagc caaatctgtt     4800

gtacattctg cacagtttgt actgcacaaa ggacgacaaa gaaaagagaa aattgaagtt     4860

tgagtatagg agccaggagt tcagtcgtgg ttccacgaat gattgggagt tgtgcctgcc     4920

agaatatacc ctgtagaaat agtacatgat gtgtgtataa aatgtagtac cttctagcaa     4980

aggcttaaca tgtagattga cttgcttaat atttgttata aaggcaaagc tagattaagt     5040

atcctgaaat gtaactcttt cctttgtgta catctgtcta atttgctgtc taggaatccc     5100

agtcagaagt tccagcctgc cactgttctc tgatgccatg ccagcaccaa ctcaactgtt     5160

ttttcctctc atccgtaact gtgaactgag caggatctat ggcactgcat gttactgcca     5220

ccacaaacat ctctgttgtt cctcatcgta cattcctcag agtcgactga gatacacacc     5280

tcatccagca tatgctacct tttgcaggcc aaaggagaac tggtggcagt acacccaagg     5340

aaggagatat gcttccacac cacagaaatt ttacctcaca cctccacaag tcaatagcat     5400

ccttaaagct aatgaataca gtttcaaagt gccagaattt gacggcaaaa atgtcagttc     5460

tatccttgga tttgacagca atcagctgcc tgcaaatgca cccattgagg accggagaag     5520

tgcagcaacc tgcttgcaga ccagagggat gcttttgggg gtttttgatg gccatgcagg     5580

ttgtgcttgt tcccaggcag tcagtgaaag actcttttat tatattgctg tctctttgtt     5640

accccatgag actttgctag agattgaaaa tgcagtggag agcggccggg cactgctacc     5700

cattctccag tggcacaagc accccaatga ttactttagt aaggaggcat ccaaattgta     5760

ctttaacagc ttgaggactt actggcaaga gcttatagac ctcaacactg gtgagtcgac     5820

tgatattgat gttaaggagg ctctaattaa tgccttcaag aggcttgata atgacatctc     5880

cttggaggcg caagttggtg atcctaattc ttttctcaac tacctggtgc ttcgagtggc     5940

attttctgga gccactgctt gtgtggccca tgtggatggt gttgaccttc atgtggccaa     6000

tactggcgat agcagagcca tgctgggtgt gcaggaagag gacggctcat ggtcagcagt     6060

cacgctgtct aatgaccaca atgctcaaaa tgaaagagaa ctagaacggc tgaaattgga     6120

acatccaaag agtgaggcca agagtgtcgt gaaacaggat cggctgcttg gcttgctgat     6180

gccatttagg gcatttggag atgtaaagtt caaatggagc attgaccttc aaaagagagt     6240

gatagaatct ggcccagacc agttgaatga caatgaatat accaagttta ttcctcctaa     6300

ttatcacaca cctccttatc tcactgctga gccagaggta acttaccacc gattaaggcc     6360

acaggataag tttctggtgt tggctactga tgggttgtgg gagactatgc ataggcagga     6420

tgtggttagg attgtgggtg agtacctaac tggcatgcat caccaacagc caatagctgt     6480

tggtggctac aaggtgactc tgggacagat gcatggcctt ttaacagaaa ggagaaccaa     6540

aatgtcctcg gtatttgagg atcagaacgc agcaacccat ctcattcgcc acgctgtggg     6600

caacaacgag tttgggactg ttgatcatga gcgcctctct aaaatgctta gtcttcctga     6660

agagcttgct cgaatgtaca gagatgacat tacaatcatt gtagttcagt tcaattctca     6720

tgttgtaggg gcgtatcaaa accaagaata gtgagtggct ctttcactgg caattctcaa     6780

atgatataca tttaaagggc agatttttta aaaagatact actataataa acatttccag     6840

ttggtcattc taagcattta cccttttgat actctagcta gtcaggtact ccaaattgac     6900

tttgcagcag ggtggcaggg tcaggagagt ctggtcctgc ctagctcaga tttcatggca     6960

cctgcacttg aagcaagtca cttctttatc acaggtgtct tgaaacatta gcttctttta     7020

ccaacctgag aaaattagga tgacctggca aataagatct tgaataggcc aaaagcaagt     7080

atcttgctgt gtgtagtctc ttggttaaag tgaagaaaca gtactgttca cacctttctt     7140

cactgagatt ccagtgtaca tgagaacata tatttattgc atgattttct agatacacag     7200

tctatgcatt attcatatac atttatttta gcctaaagtg gttttcaaat ccagttcttc     7260

aagccataaa tgaccaagat ccaagcaatc tgaatttgtt tttgtgatta tttgactgga     7320

atgcttctta agtggaataa ctatactccg ttatccaccc gatttcctaa tgtaattgaa     7380

agattttcta ttttgccaca cacttggaga caataagggt ttttagtttt atctactctt     7440

ctattgaagt taaagaaaga aaaaaagatt tttttatttg tattaatgaa aagctttagt     7500

ttaaaataag gagatccaga ataaaaagaa gagactgatc tcttcaatta ttgtcatctg     7560

tagccaccag cacatcactc ttatgtaatc cccaaaggct tggcatgccg taagtgtgtg     7620

gtgggtagac tgctgccggg gaatcgtact tcttatttag taatgataag acttttcatt     7680

atttttggaa ttttaaagat gacataaata agtttaaata tcaatttggg gagtaaggtt     7740

taatattgcc atcgggtatt gagacaggag gaagtttctg tttttctcca tttagacata     7800

ggtcaattaa aatatttggg tttaaaatga ctaaatgctt taaacatatt gtagcttaag     7860

atatatgtgt taagatatat acatgagaaa ctttaaaagg taactactgt gcatgcctga     7920

tgcttaatag aatacttagt ggcatcaaat gtttgcagca gtctccataa ttatattcag     7980

tcccttctaa tactgtatca atgtaaatga aataaatata ttcaaattgg ctttttgata     8040

tgcatcaagt ggcattttgt tcctgtgttt aatagtgatc tgtatacagc tgtgcacata     8100

ttgtcatcac ttattctagc atcactgtta aggctgtgat tatgtttgat attcacctgg     8160

attttaatac aagccaatat cagcttccca ttgtgtaata acttgggtgt ttaggagtct     8220

tttcacattt tttggggata tgaactagat gttcaagaac tccttctgga ctgtggatac     8280

tgaatcagtg tactattggc tgcagaattt gtttcaattg aaaatagact caggaagatt     8340

gctgctcaga atatcatata atgtttattt tttgaggtgt ttttgttttt atttgtgtgt     8400

tttttttttt ttaagtcagc ttggaacttt tttcctgggt agtatttggg agagggaaag     8460

gctgtactat atatttattt ctaaatgttt tgactgggca tttttctttt aatgaaatat     8520

gtggactgct ctagcaaacc ctattttcag ctactatttg aatattcttg aacaccacca     8580

ctgaagagtt tcatatacac caaataatgt ctcatctcta tagtacaggg aatataaaat     8640

tggtttcctg tggtcatgat caagatagta gtattattac acaagaaact tggtctgcag     8700

tctggaagct tgtctgctct atagaaatga aaatgcagca tgaagttgac attgtggaaa     8760

tgaaagtaat tgggtattag aaatctgaaa gtactgtcat ctaaaagcaa ttgtgatttt     8820

attgtaattg gttgtcactg ttgtacggtg tctagaatta aagaatacat gtaaactttc     8880

atggtattta gcctttctta aattttttta aaatttaaac tttctaacct atgtattcaa     8940

cttctgtatt tatatttaat cagtggttca tgttatataa tacaccctta actagttaaa     9000

tggaatgttg gtatggtaca gagtaccata ttgctaagaa aactgtctta taaaagatgt     9060

atatgtgtga agacatgaaa gtttaatgta cagaatggtt ggagaaatgc ctatggtgaa     9120

ttaaagcttc atatctgctt tctgaa                                          9146


<210>  4
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ala Pro Thr Gln Leu Phe Phe Pro Leu Ile Arg Asn Cys Glu 
1               5                   10                  15      


Leu Ser Arg Ile Tyr Gly Thr Ala Cys Tyr Cys His His Lys His Leu 
            20                  25                  30          


Cys Cys Ser Ser Ser Tyr Ile Pro Gln Ser Arg Leu Arg Tyr Thr Pro 
        35                  40                  45              


His Pro Ala Tyr Ala Thr Phe Cys Arg Pro Lys Glu Asn Trp Trp Gln 
    50                  55                  60                  


Tyr Thr Gln Gly Arg Arg Tyr Ala Ser Thr Pro Gln Lys Phe Tyr Leu 
65                  70                  75                  80  


Thr Pro Pro Gln Val Asn Ser Ile Leu Lys Ala Asn Glu Tyr Ser Phe 
                85                  90                  95      


Lys Val Pro Glu Phe Asp Gly Lys Asn Val Ser Ser Ile Leu Gly Phe 
            100                 105                 110         


Asp Ser Asn Gln Leu Pro Ala Asn Ala Pro Ile Glu Asp Arg Arg Ser 
        115                 120                 125             


Ala Ala Thr Cys Leu Gln Thr Arg Gly Met Leu Leu Gly Val Phe Asp 
    130                 135                 140                 


Gly His Ala Gly Cys Ala Cys Ser Gln Ala Val Ser Glu Arg Leu Phe 
145                 150                 155                 160 


Tyr Tyr Ile Ala Val Ser Leu Leu Pro His Glu Thr Leu Leu Glu Ile 
                165                 170                 175     


Glu Asn Ala Val Glu Ser Gly Arg Ala Leu Leu Pro Ile Leu Gln Trp 
            180                 185                 190         


His Lys His Pro Asn Asp Tyr Phe Ser Lys Glu Ala Ser Lys Leu Tyr 
        195                 200                 205             


Phe Asn Ser Leu Arg Thr Tyr Trp Gln Glu Leu Ile Asp Leu Asn Thr 
    210                 215                 220                 


Gly Glu Ser Thr Asp Ile Asp Val Lys Glu Ala Leu Ile Asn Ala Phe 
225                 230                 235                 240 


Lys Arg Leu Asp Asn Asp Ile Ser Leu Glu Ala Gln Val Gly Asp Pro 
                245                 250                 255     


Asn Ser Phe Leu Asn Tyr Leu Val Leu Arg Val Ala Phe Ser Gly Ala 
            260                 265                 270         


Thr Ala Cys Val Ala His Val Asp Gly Val Asp Leu His Val Ala Asn 
        275                 280                 285             


Thr Gly Asp Ser Arg Ala Met Leu Gly Val Gln Glu Glu Asp Gly Ser 
    290                 295                 300                 


Trp Ser Ala Val Thr Leu Ser Asn Asp His Asn Ala Gln Asn Glu Arg 
305                 310                 315                 320 


Glu Leu Glu Arg Leu Lys Leu Glu His Pro Lys Ser Glu Ala Lys Ser 
                325                 330                 335     


Val Val Lys Gln Asp Arg Leu Leu Gly Leu Leu Met Pro Phe Arg Ala 
            340                 345                 350         


Phe Gly Asp Val Lys Phe Lys Trp Ser Ile Asp Leu Gln Lys Arg Val 
        355                 360                 365             


Ile Glu Ser Gly Pro Asp Gln Leu Asn Asp Asn Glu Tyr Thr Lys Phe 
    370                 375                 380                 


Ile Pro Pro Asn Tyr His Thr Pro Pro Tyr Leu Thr Ala Glu Pro Glu 
385                 390                 395                 400 


Val Thr Tyr His Arg Leu Arg Pro Gln Asp Lys Phe Leu Val Leu Ala 
                405                 410                 415     


Thr Asp Gly Leu Trp Glu Thr Met His Arg Gln Asp Val Val Arg Ile 
            420                 425                 430         


Val Gly Glu Tyr Leu Thr Gly Met His His Gln Gln Pro Ile Ala Val 
        435                 440                 445             


Gly Gly Tyr Lys Val Thr Leu Gly Gln Met His Gly Leu Leu Thr Glu 
    450                 455                 460                 


Arg Arg Thr Lys Met Ser Ser Val Phe Glu Asp Gln Asn Ala Ala Thr 
465                 470                 475                 480 


His Leu Ile Arg His Ala Val Gly Asn Asn Glu Phe Gly Thr Val Asp 
                485                 490                 495     


His Glu Arg Leu Ser Lys Met Leu Ser Leu Pro Glu Glu Leu Ala Arg 
            500                 505                 510         


Met Tyr Arg Asp Asp Ile Thr Ile Ile Val Val Gln Phe Asn Ser His 
        515                 520                 525             


Val Val Gly Ala Tyr Gln Asn Gln Glu 
    530                 535         


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary tobacco etch virus (TEV) protease cleavage site


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  "X" is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  "X" is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  "X" is G or S

<400>  5

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary tobacco etch virus (TEV) protease cleavage sites

<400>  6

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary tobacco etch virus (TEV) protease cleavage site

<400>  7

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  8

Asp Gly Gly Gly Ser 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  9

Thr Gly Glu Lys Pro 
1               5   


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  10

Gly Gly Arg Arg 
1               


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Sequence repeated 1, 2, 3, 4 or 5 times

<400>  11

Gly Gly Gly Gly Ser 
1               5   


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  12

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  13

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  14

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  15

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  16
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  16

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  17
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker

<400>  17

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  18
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Trp Asp Met Cys Asn Gln Asp Ser Glu Ser Val Trp Ser Asp 
1               5                   10                  15      


Ile Glu Cys Ala Ala Leu Val Gly Glu Asp Gln Pro Leu Cys Pro Asp 
            20                  25                  30          


Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val Asn Asp Leu Asp Thr 
        35                  40                  45              


Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser Asp Gln Ser Glu Ile 
    50                  55                  60                  


Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn Ile Phe Glu Lys Ile 
65                  70                  75                  80  


Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val Leu Thr Glu Thr Leu 
                85                  90                  95      


Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro Ser Phe Asp Ala Leu 
            100                 105                 110         


Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala Ser Pro Ser Ser Met 
        115                 120                 125             


Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu Glu Pro Ser Leu Leu 
    130                 135                 140                 


Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln Leu Ser Tyr Asn Glu 
145                 150                 155                 160 


Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn His Asn His Arg Ile 
                165                 170                 175     


Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn Ser Trp Ser Asn Lys 
            180                 185                 190         


Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln Arg Arg Pro Cys Ser 
        195                 200                 205             


Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp Pro Pro His Thr Lys 
    210                 215                 220                 


Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys Cys Thr Ser Lys Lys 
225                 230                 235                 240 


Lys Ser His Thr Gln Ser Gln Ser Gln His Leu Gln Ala Lys Pro Thr 
                245                 250                 255     


Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro Asn Asp Pro Lys Gly 
            260                 265                 270         


Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr Leu Ser Val Glu Leu 
        275                 280                 285             


Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr Pro Pro His Lys Ala 
    290                 295                 300                 


Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys Leu Lys Ser Ser Cys 
305                 310                 315                 320 


Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro Arg Tyr Ser Glu Ser 
                325                 330                 335     


Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys Gly Pro Glu Gln Ser 
            340                 345                 350         


Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val Leu Thr Gly Gly His 
        355                 360                 365             


Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg Leu Phe Gly Asp His 
    370                 375                 380                 


Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu Ile Leu Ile Asn Ile 
385                 390                 395                 400 


Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu Asn Lys Asp Val Ser 
                405                 410                 415     


Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr Asp Ser Asp Gln Cys 
            420                 425                 430         


Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln Val Ser Pro Cys Ser 
        435                 440                 445             


Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg Ala Glu Leu Asn Lys 
    450                 455                 460                 


His Phe Gly His Pro Ser Gln Ala Val Phe Asp Asp Glu Ala Asp Lys 
465                 470                 475                 480 


Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn Glu Gln Phe Ser Lys 
                485                 490                 495     


Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met Asp Gly Leu Phe Asp 
            500                 505                 510         


Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr Pro Trp Asp Gly Thr 
        515                 520                 525             


Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser Cys Ser Ser Phe Asn 
    530                 535                 540                 


Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys Ser Leu Phe Ser Gln 
545                 550                 555                 560 


Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser Phe Ser Arg His Arg 
                565                 570                 575     


Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg Ser Arg Ser Pro Gly 
            580                 585                 590         


Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr Glu Ser Ser His Tyr 
        595                 600                 605             


Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr Val Arg Ser Arg Ser 
    610                 615                 620                 


Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp Ser Tyr Glu Glu Tyr 
625                 630                 635                 640 


Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg Arg Glu Tyr Glu Lys 
                645                 650                 655     


Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg Gln Arg Gln Lys Ala 
            660                 665                 670         


Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys Ile Arg Pro Asp Thr 
        675                 680                 685             


Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val Phe Gly Glu Ile Glu 
    690                 695                 700                 


Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp Ser Tyr Gly Phe Ile 
705                 710                 715                 720 


Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala Leu Glu Asn Gly Tyr 
                725                 730                 735     


Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu Leu Tyr Phe Cys Gly 
            740                 745                 750         


Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp Leu Asp Ser Asn Ser 
        755                 760                 765             


Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys Tyr Asp Ser Leu Asp 
    770                 775                 780                 


Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser Leu Arg Arg 
785                 790                 795             


<210>  19
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asp Glu Thr Ser Pro Arg Leu Glu Glu Asp Trp Lys Lys Val Leu 
1               5                   10                  15      


Gln Arg Glu Ala Gly Trp Gln Cys Ala Ala Leu Val Gly Glu Asp Gln 
            20                  25                  30          


Pro Leu Cys Pro Asp Leu Pro Glu Leu Asp Leu Ser Glu Leu Asp Val 
        35                  40                  45              


Asn Asp Leu Asp Thr Asp Ser Phe Leu Gly Gly Leu Lys Trp Cys Ser 
    50                  55                  60                  


Asp Gln Ser Glu Ile Ile Ser Asn Gln Tyr Asn Asn Glu Pro Ser Asn 
65                  70                  75                  80  


Ile Phe Glu Lys Ile Asp Glu Glu Asn Glu Ala Asn Leu Leu Ala Val 
                85                  90                  95      


Leu Thr Glu Thr Leu Asp Ser Leu Pro Val Asp Glu Asp Gly Leu Pro 
            100                 105                 110         


Ser Phe Asp Ala Leu Thr Asp Gly Asp Val Thr Thr Asp Asn Glu Ala 
        115                 120                 125             


Ser Pro Ser Ser Met Pro Asp Gly Thr Pro Pro Pro Gln Glu Ala Glu 
    130                 135                 140                 


Glu Pro Ser Leu Leu Lys Lys Leu Leu Leu Ala Pro Ala Asn Thr Gln 
145                 150                 155                 160 


Leu Ser Tyr Asn Glu Cys Ser Gly Leu Ser Thr Gln Asn His Ala Asn 
                165                 170                 175     


His Asn His Arg Ile Arg Thr Asn Pro Ala Ile Val Lys Thr Glu Asn 
            180                 185                 190         


Ser Trp Ser Asn Lys Ala Lys Ser Ile Cys Gln Gln Gln Lys Pro Gln 
        195                 200                 205             


Arg Arg Pro Cys Ser Glu Leu Leu Lys Tyr Leu Thr Thr Asn Asp Asp 
    210                 215                 220                 


Pro Pro His Thr Lys Pro Thr Glu Asn Arg Asn Ser Ser Arg Asp Lys 
225                 230                 235                 240 


Cys Thr Ser Lys Lys Lys Ser His Thr Gln Ser Gln Ser Gln His Leu 
                245                 250                 255     


Gln Ala Lys Pro Thr Thr Leu Ser Leu Pro Leu Thr Pro Glu Ser Pro 
            260                 265                 270         


Asn Asp Pro Lys Gly Ser Pro Phe Glu Asn Lys Thr Ile Glu Arg Thr 
        275                 280                 285             


Leu Ser Val Glu Leu Ser Gly Thr Ala Gly Leu Thr Pro Pro Thr Thr 
    290                 295                 300                 


Pro Pro His Lys Ala Asn Gln Asp Asn Pro Phe Arg Ala Ser Pro Lys 
305                 310                 315                 320 


Leu Lys Ser Ser Cys Lys Thr Val Val Pro Pro Pro Ser Lys Lys Pro 
                325                 330                 335     


Arg Tyr Ser Glu Ser Ser Gly Thr Gln Gly Asn Asn Ser Thr Lys Lys 
            340                 345                 350         


Gly Pro Glu Gln Ser Glu Leu Tyr Ala Gln Leu Ser Lys Ser Ser Val 
        355                 360                 365             


Leu Thr Gly Gly His Glu Glu Arg Lys Thr Lys Arg Pro Ser Leu Arg 
    370                 375                 380                 


Leu Phe Gly Asp His Asp Tyr Cys Gln Ser Ile Asn Ser Lys Thr Glu 
385                 390                 395                 400 


Ile Leu Ile Asn Ile Ser Gln Glu Leu Gln Asp Ser Arg Gln Leu Glu 
                405                 410                 415     


Asn Lys Asp Val Ser Ser Asp Trp Gln Gly Gln Ile Cys Ser Ser Thr 
            420                 425                 430         


Asp Ser Asp Gln Cys Tyr Leu Arg Glu Thr Leu Glu Ala Ser Lys Gln 
        435                 440                 445             


Val Ser Pro Cys Ser Thr Arg Lys Gln Leu Gln Asp Gln Glu Ile Arg 
    450                 455                 460                 


Ala Glu Leu Asn Lys His Phe Gly His Pro Ser Gln Ala Val Phe Asp 
465                 470                 475                 480 


Asp Glu Ala Asp Lys Thr Gly Glu Leu Arg Asp Ser Asp Phe Ser Asn 
                485                 490                 495     


Glu Gln Phe Ser Lys Leu Pro Met Phe Ile Asn Ser Gly Leu Ala Met 
            500                 505                 510         


Asp Gly Leu Phe Asp Asp Ser Glu Asp Glu Ser Asp Lys Leu Ser Tyr 
        515                 520                 525             


Pro Trp Asp Gly Thr Gln Ser Tyr Ser Leu Phe Asn Val Ser Pro Ser 
    530                 535                 540                 


Cys Ser Ser Phe Asn Ser Pro Cys Arg Asp Ser Val Ser Pro Pro Lys 
545                 550                 555                 560 


Ser Leu Phe Ser Gln Arg Pro Gln Arg Met Arg Ser Arg Ser Arg Ser 
                565                 570                 575     


Phe Ser Arg His Arg Ser Cys Ser Arg Ser Pro Tyr Ser Arg Ser Arg 
            580                 585                 590         


Ser Arg Ser Pro Gly Ser Arg Ser Ser Ser Arg Ser Cys Tyr Tyr Tyr 
        595                 600                 605             


Glu Ser Ser His Tyr Arg His Arg Thr His Arg Asn Ser Pro Leu Tyr 
    610                 615                 620                 


Val Arg Ser Arg Ser Arg Ser Pro Tyr Ser Arg Arg Pro Arg Tyr Asp 
625                 630                 635                 640 


Ser Tyr Glu Glu Tyr Gln His Glu Arg Leu Lys Arg Glu Glu Tyr Arg 
                645                 650                 655     


Arg Glu Tyr Glu Lys Arg Glu Ser Glu Arg Ala Lys Gln Arg Glu Arg 
            660                 665                 670         


Gln Arg Gln Lys Ala Ile Glu Glu Arg Arg Val Ile Tyr Val Gly Lys 
        675                 680                 685             


Ile Arg Pro Asp Thr Thr Arg Thr Glu Leu Arg Asp Arg Phe Glu Val 
    690                 695                 700                 


Phe Gly Glu Ile Glu Glu Cys Thr Val Asn Leu Arg Asp Asp Gly Asp 
705                 710                 715                 720 


Ser Tyr Gly Phe Ile Thr Tyr Arg Tyr Thr Cys Asp Ala Phe Ala Ala 
                725                 730                 735     


Leu Glu Asn Gly Tyr Thr Leu Arg Arg Ser Asn Glu Thr Asp Phe Glu 
            740                 745                 750         


Leu Tyr Phe Cys Gly Arg Lys Gln Phe Phe Lys Ser Asn Tyr Ala Asp 
        755                 760                 765             


Leu Asp Ser Asn Ser Asp Asp Phe Asp Pro Ala Ser Thr Lys Ser Lys 
    770                 775                 780                 


Tyr Asp Ser Leu Asp Phe Asp Ser Leu Leu Lys Glu Ala Gln Arg Ser 
785                 790                 795                 800 


Leu Arg Arg 


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary phosphorothioate antisense oligonucleotides

<400>  20
agctggctgg tggtcctggc                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary phosphorothioate antisense oligonucleotides

<400>  21
tgaatgatgc ccttgccgtg                                                   20


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary PDK1 RNAi sequence

<400>  22
gctctgtcaa cagactcaat a                                                 21


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary PDK1 RNAi sequence

<400>  23
catccgttca attggtacaa a                                                 21


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Exemplary PDK1 RNAi sequence

<400>  24
cgtgaatatg ttgaagtaga a                                                 21

            


