                         SEQUENCE LISTING

<110>  REGENXBIO INC
 
<120>  VECTORIZED ANTI-TNF-? ANTIBODIES FOR OCULAR INDICATIONS

<130>  38013.0015P1

<150>  63/106,832
<151>  2020-10-28

<160>  277   

<170>  PatentIn version 3.5

<210>  1
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Adalimumab


<220>
<221>  misc
<222>  (226)..(229)
<223>  amino acids 226 to 229 can be present or absent

<220>
<221>  misc
<222>  (230)..(236)
<223>  amino acids 230 to 236 can be present or absent

<220>
<221>  misc
<222>  (237)..(246)
<223>  amino acids 237 to 246 can be present or absent

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu 
                245     


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Adalimumab

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Infliximab


<220>
<221>  misc
<222>  (224)..(228)
<223>  amino acids 224 to 228 can be present or absent

<220>
<221>  misc
<222>  (229)..(234)
<223>  amino acids 229 to 234 can be present or absent

<220>
<221>  misc
<222>  (234)..(245)
<223>  amino acids 235 to 245 can be present or absent

<400>  3

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu 
                245 


<210>  4
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Infliximab

<400>  4

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Golimumab


<220>
<221>  misc
<222>  (234)..(237)
<223>  amino acids 234 to 237 can be present or absent

<220>
<221>  misc
<222>  (238)..(243)
<223>  amino acids 238 to 243 can be present or absent

<220>
<221>  misc
<222>  (244)..(254)
<223>  amino acids 238 to 243 can be present or absent

<220>
<221>  misc
<222>  (244)..(254)
<223>  amino acids 244 to 254 can be present or absent

<400>  5

Ser Lys Leu Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
1               5                   10                  15      


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe 
            20                  25                  30          


Ser Ser Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Phe Met Ser Tyr Asp Gly Ser Asn Lys Lys Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr 
            100                 105                 110         


Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
    130                 135                 140                 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
145                 150                 155                 160 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
                165                 170                 175     


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
            180                 185                 190         


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
        195                 200                 205             


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
    210                 215                 220                 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 


<210>  6
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Golimumab

<400>  6

Ala Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu 
1               5                   10                  15      


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 
            20                  25                  30          


Tyr Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
        35                  40                  45              


Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn 
                85                  90                  95      


Trp Pro Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  7
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Satralizumab


<220>
<221>  misc
<222>  (225)..(230)
<223>  amino acids 225 to 230 can be present or absent

<220>
<221>  misc
<222>  (231)..(235)
<223>  amino acids 231 to 235 can be present or absent

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly His Ser Ile Ser His Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Glu Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Phe Ile Ser Tyr Ser Gly Ile Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Glu Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Ser Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235 


<210>  8
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Satralizumab

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Ser Val Thr Ile Thr Cys Gln Ala Ser Thr Asp Ile Ser Ser His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Gly Ser His Leu Leu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gly Gln Gly Asn Arg Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Glu Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  9
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Sarilumab


<220>
<221>  misc
<222>  (221)..(224)
<223>  amino acids 221 to 224 can be present or absent

<220>
<221>  misc
<222>  (225)..(230)
<223>  amino acids 225 to 230 can be present or absent

<220>
<221>  misc
<222>  (231)..(241)
<223>  amino acids 231 to 241 can be present or absent

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Arg Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Arg Asp Ser Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210>  10
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sythetic construct; light chain Sarilumab

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ser Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  11
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Siltuximab


<220>
<221>  misc
<222>  (224)..(227)
<223>  amino acids 224 to 227 can be present or absent

<220>
<221>  misc
<222>  (228)..(233)
<223>  amino acids 228 to 233 can be present or absent

<220>
<221>  misc
<222>  (234)..(244)
<223>  amino acids 234 to 244 can be present or absent

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Lys Leu Leu Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Trp Gly Tyr Tyr Ala Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210>  12
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Siltuximab

<400>  12

Gln Ile Val Leu Ile Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  13
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Clazakizumab


<220>
<221>  misc
<222>  (225)..(228)
<223>  amino acids 225 to 228 can be present or absent

<220>
<221>  misc
<222>  (229)..(234)
<223>  amino acids 229 to 234 can be present or absent

<220>
<221>  misc
<222>  (235)..(245)
<223>  amino acids 235 to 245 can be present or absent

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Asn Tyr 
            20                  25                  30          


Tyr Val Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ile Ile Tyr Gly Ser Asp Glu Thr Ala Tyr Ala Thr Ser Ala Ile 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Asp Ser Ser Asp Trp Asp Ala Lys Phe Asn Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu 
                245 


<210>  14
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Clazakizumab

<400>  14

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Asn Asn Glu 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Arg Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Leu Arg Asn 
                85                  90                  95      


Ile Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  15
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Sirukumab


<220>
<221>  misc
<222>  (224)..(227)
<223>  amino acids 224 to 227 can be present or absent

<220>
<221>  misc
<222>  (228)..(233)
<223>  amino acids 228 to 233 can be present or absent

<220>
<221>  misc
<222>  (234)..(244)
<223>  amino acids 234 to 244 can be present or absent

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro Phe 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Lys Ile Ser Pro Gly Gly Ser Trp Thr Tyr Tyr Ser Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Trp Gly Tyr Tyr Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210>  16
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Sirukumab

<400>  16

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Ser Ile Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Met Ser Asn Leu Ala Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Met Gln Trp Ser Gly Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  17
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Olokizumab


<220>
<221>  mis
<222>  (223)..(231)
<223>  amino acids 223 to 231 can be present or absent

<220>
<221>  mis
<222>  (232)..(242)
<223>  amino acids 232 to 242 can be present or absent

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Asp Tyr 
            20                  25                  30          


Phe Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gln Met Arg Asn Lys Asn Tyr Gln Tyr Gly Thr Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Leu Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Glu Ser Tyr Tyr Gly Phe Thr Ser Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu 
        


<210>  18
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Olokizumab

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Ile Ser 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  19
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Gerilimzumab


<220>
<221>  misc
<222>  (227)..(230)
<223>  amino acids 227 to 230 can be present or absent

<220>
<221>  misc
<222>  (231)..(236)
<223>  amino acids 231 to 236 can be present or absent

<220>
<221>  misc
<222>  (237)..(247)
<223>  amino acids 237 to 247 can be present or absent

<400>  19

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Thr Ser Arg 
            20                  25                  30          


Tyr Tyr Ala Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Val Ile Asp Tyr Asp Gly Asp Thr Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ser Ile Ser Trp Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Pro Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Pro Asp Val Val Thr Gly Phe His Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu 
                245         


<210>  20
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Gerilimzumab

<400>  20

Gln Ser Ala Leu Thr Gln Pro Pro Ser Val Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Ala Gly Ala Asn Asn Asp Ile Gly Thr Tyr 
            20                  25                  30          


Ala Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Lys Val Thr Thr Arg Ala Ser Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Tyr Arg Asn Phe 
                85                  90                  95      


Asn Asn Ala Val Phe Gly Thr Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  21
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Tocilizumab


<220>
<221>  misc
<222>  (224)..(227)
<223>  amino acids 224 to 227 can be present or absent

<220>
<221>  misc
<222>  (228)..(233)
<223>  amino acids 228 to 233 can be present or absent

<220>
<221>  misc
<222>  (234)..(244)
<223>  amino acids 234 to 244 can be present or absent

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Arg Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


His Ala Trp Ser Trp Val Arg Gln Pro Pro Gly Arg Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Ser Gly Ile Thr Thr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Leu Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Arg Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Arg Thr Thr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ser Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu 
                


<210>  22
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Tocilizumab

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  23
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Adalimumab Heavy Chain

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  24
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Adalimumab Vectorized IgG- fully encoded 
       protein

<400>  24

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Arg Lys Arg Arg Gly Ser Gly Glu Gly 
465                 470                 475                 480 


Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
                485                 490                 495     


Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
            500                 505                 510         


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
        515                 520                 525             


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
    530                 535                 540                 


Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
545                 550                 555                 560 


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
                565                 570                 575     


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
            580                 585                 590         


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn 
        595                 600                 605             


Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
    610                 615                 620                 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
625                 630                 635                 640 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
                645                 650                 655     


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
            660                 665                 670         


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
        675                 680                 685             


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
    690                 695                 700                 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
705                 710                 715                 720 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730 


<210>  25
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Adalimumab Vectorized Fab- fully encoded 
       protein

<400>  25

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Arg Lys Arg Arg Gly Ser Gly Glu 
                245                 250                 255     


Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly 
            260                 265                 270         


Pro Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala 
        275                 280                 285             


Leu Val Thr Asn Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    290                 295                 300                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
305                 310                 315                 320 


Gly Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                325                 330                 335     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro 
            340                 345                 350         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        355                 360                 365             


Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr 
    370                 375                 380                 


Asn Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
385                 390                 395                 400 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
                405                 410                 415     


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            420                 425                 430         


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        435                 440                 445             


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    450                 455                 460                 


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
465                 470                 475                 480 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                485                 490                 495     


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            500                 505         


<210>  26
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (676)..(687)
<223>  nucleotides 676 to 687 can be present or absent

<220>
<221>  misc
<222>  (688)..(705)
<223>  nucleotides 688 to 705 can be present or absent

<220>
<221>  misc
<222>  (706)..(738)
<223>  nucleotides706 to 738 can be present or absent

<400>  26

Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Gly 
1               5                   10                  15      


Ala Gly Ala Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Cys Ala Gly Cys Cys Cys Gly Gly Cys Ala Gly Gly 
        35                  40                  45              


Ala Gly Cys Cys Thr Gly Ala Gly Gly Cys Thr Gly Ala Gly Cys Thr 
    50                  55                  60                  


Gly Cys Gly Cys Cys Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Gly Ala Cys Gly Ala Cys Thr Ala Cys 
                85                  90                  95      


Gly Cys Cys Ala Thr Gly Cys Ala Cys Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Gly Gly Cys Ala Gly Gly Cys Cys Cys Cys Cys Gly Gly Cys Ala Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ala Gly Cys Gly Cys Cys Ala Thr Cys Ala Cys Cys Thr Gly Gly Ala 
145                 150                 155                 160 


Ala Cys Ala Gly Cys Gly Gly Cys Cys Ala Cys Ala Thr Cys Gly Ala 
                165                 170                 175     


Cys Thr Ala Cys Gly Cys Cys Gly Ala Cys Ala Gly Cys Gly Thr Gly 
            180                 185                 190         


Gly Ala Gly Gly Gly Cys Ala Gly Gly Thr Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Ala Gly Cys Ala Gly Gly Gly Ala Cys Ala Ala Cys Gly Cys 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Gly Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys 
        275                 280                 285             


Gly Cys Cys Ala Ala Gly Gly Thr Gly Ala Gly Cys Thr Ala Cys Cys 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Cys Cys Gly Cys Cys Ala Gly Cys Ala Gly 
305                 310                 315                 320 


Cys Cys Thr Gly Gly Ala Cys Thr Ala Cys Thr Gly Gly Gly Gly Cys 
                325                 330                 335     


Cys Ala Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Gly Thr Gly Ala 
            340                 345                 350         


Cys Cys Gly Thr Gly Ala Gly Cys Ala Gly Cys Gly Cys Cys Ala Gly 
        355                 360                 365             


Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys Cys Cys Cys Ala Gly Cys 
    370                 375                 380                 


Gly Thr Gly Thr Thr Cys Cys Cys Cys Cys Thr Gly Gly Cys Cys Cys 
385                 390                 395                 400 


Cys Cys Ala Gly Cys Ala Gly Cys Ala Ala Gly Ala Gly Cys Ala Cys 
                405                 410                 415     


Cys Ala Gly Cys Gly Gly Cys Gly Gly Cys Ala Cys Cys Gly Cys Cys 
            420                 425                 430         


Gly Cys Cys Cys Thr Gly Gly Gly Cys Thr Gly Cys Cys Thr Gly Gly 
        435                 440                 445             


Thr Gly Ala Ala Gly Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys Cys 
    450                 455                 460                 


Cys Gly Ala Gly Cys Cys Cys Gly Thr Gly Ala Cys Cys Gly Thr Gly 
465                 470                 475                 480 


Ala Gly Cys Thr Gly Gly Ala Ala Cys Ala Gly Cys Gly Gly Cys Gly 
                485                 490                 495     


Cys Cys Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly Thr 
            500                 505                 510         


Gly Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Cys Gly Cys Cys 
        515                 520                 525             


Gly Thr Gly Cys Thr Gly Cys Ala Gly Ala Gly Cys Ala Gly Cys Gly 
    530                 535                 540                 


Gly Cys Cys Thr Gly Thr Ala Cys Ala Gly Cys Cys Thr Gly Ala Gly 
545                 550                 555                 560 


Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr Gly 
                565                 570                 575     


Cys Cys Cys Ala Gly Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Gly 
            580                 585                 590         


Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys Thr Ala Cys Ala Thr 
        595                 600                 605             


Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly Ala Ala Cys Cys Ala Cys 
    610                 615                 620                 


Ala Ala Gly Cys Cys Cys Ala Gly Cys Ala Ala Cys Ala Cys Cys Ala 
625                 630                 635                 640 


Ala Gly Gly Thr Gly Gly Ala Cys Ala Ala Gly Ala Ala Gly Gly Thr 
                645                 650                 655     


Gly Gly Ala Gly Cys Cys Cys Ala Ala Gly Ala Gly Cys Thr Gly Cys 
            660                 665                 670         


Gly Ala Cys Ala Ala Gly Ala Cys Cys Cys Ala Cys Ala Cys Cys Thr 
        675                 680                 685             


Gly Cys Cys Cys Cys Cys Cys Cys Thr Gly Cys Cys Cys Cys Gly Cys 
    690                 695                 700                 


Cys Cys Cys Cys Gly Ala Gly Cys Thr Gly Cys Thr Gly Gly Gly Cys 
705                 710                 715                 720 


Gly Gly Cys Cys Cys Cys Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys 
                725                 730                 735     


Thr Gly 
        


<210>  27
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody

<400>  27
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gggcatcagg aactacctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gccagcaccc tgcagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacgtgg ccacctacta ctgccagagg tacaacaggg ccccctacac cttcggccag      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  28
<211>  734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (673)..(684)
<223>  nucleotides 673 to 684 can be present or absent

<220>
<221>  misc
<222>  (685)..(702)
<223>  nucleotides 685 to 702 can be present or absent

<220>
<221>  misc
<222>  (703)..(734)
<223>  nucleotides 703 to 734 can be present or absent

<400>  28
gaggtgaagc tggaggagag cggcggcggc ctggtgcagc ccggcggcag catgaagctg       60

agctgcgtgg ccagcggctt catcttcagc aaccactgga tgaactgggt gaggcagagc      120

cccgagaagg gcctggagtg ggtggccgag atcaggagca agagcatcaa cagcgccacc      180

cactacgccg agagcgtgaa gggcaggttc accatcagca gggacgacag caagagcgcc      240

gtgtacctgc agatgaccga cctgaggacc gaggacaccg gcgtgtacta ctgcagcagg      300

aactactacg gcagcaccta cgactactgg ggccagggca ccaccctgac cgtgagcagc      360

gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc      420

ggcaccgccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc      480

tggaacagcg gcgccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      660

aagagctgcg acaagaccca cacctgcccc ccctgccccg cccccgagct gctgggcggc      720

cccagcggtt cctg                                                        734


<210>  29
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  29
gacatcctgc tgacccagag ccccgccatc ctgagcgtga gccccggcga gagggtgagc       60

ttcagctgca gggccagcca gttcgtgggc agcagcatcc actggtacca gcagaggacc      120

aacggcagcc ccaggctgct gatcaagtac gccagcgaga gcatgagcgg catccccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga gcatcaacac cgtggagagc      240

gaggacatcg ccgactacta ctgccagcag agccacagct ggcccttcac cttcggcagc      300

ggcaccaacc tggaggtgaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  30
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (659)..(669)
<223>  amino acids 659 to 669 can be present or absent

<220>
<221>  misc
<222>  (670)..(687)
<223>  amino acids 670 to 687 can be present or absent

<220>
<221>  misc
<222>  (688)..(720)
<223>  amino acids 688 to 720 can be present or absent

<400>  30
agcaagctgc aggtgcagct ggtggagagc ggcggcggcg tggtgcagcc cggcaggagc       60

ctgaggctga gctgcgccgc cagcggcttc atcttcagca gctacgccat gcactgggtg      120

aggcaggccc ccggcaacgg cctggagtgg gtggccttca tgagctacga cggcagcaac      180

aagaagtacg ccgacagcgt gaagggcagg ttcaccatca gcagggacaa cagcaagaac      240

accctgtacc tgcagatgaa cagcctgagg gccgaggaca ccgccgtgta ctactgcgcc      300

agggacaggg gcatcgccgc cggcggcaac tactactact acggcatgga cgtgtggggc      360

cagggcacca ccgtgaccgt gagcagcgcc agcaccaagg gccccagcgt gttccccctg      420

gcccccagca gcaagagcac cagcggcggc accgccgccc tgggctgcct ggtgaaggac      480

tacttccccg agcccgtgac cgtgagctgg aacagcggcg ccctgaccag cggcgtgcac      540

accttccccg ccgtgctgca gagcagcggc ctgtacagcc tgagcagcgt ggtgaccgtg      600

cccagcagca gcctgggcac ccagacctac atctgcaacg tgaaccacaa gcccagcaag      660

acccacacct gccccccctg ccccgccccc gagctgctgg gcggccccag cgtgttcctg      720


<210>  31
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  31
gccggcagcg agatcgtgct gacccagagc cccgccaccc tgagcctgag ccccggcgag       60

agggccaccc tgagctgcag ggccagccag agcgtgtaca gctacctggc ctggtaccag      120

cagaagcccg gccaggcccc caggctgctg atctacgacg ccagcaacag ggccaccggc      180

atccccgcca ggttcagcgg cagcggcagc ggcaccgact tcaccctgac catcagcagc      240

ctggagcccg aggacttcgc cgtgtactac tgccagcaga ggagcaactg gccccccttc      300

accttcggcc ccggcaccaa ggtggacatc aagaggaccg tggccgcccc cagcgtgttc      360

atcttccccc ccagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgcctgctg      420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc      480

ggcaacagcc aggagagcgt gaccgagcag gacagcaagg acagcaccta cagcctgagc      540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgcgaggtg      600

acccaccagg gcctgagcag ccccgtgacc aagagcttca acaggggcga gtgc            654


<210>  32
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (673)..(690)
<223>  amino acids 673 to 690 can be present or absent

<220>
<221>  misc
<222>  (691)..(705)
<223>  amino acids 691 to 705 can be present or absent

<400>  32
caggtgcagc tgcaggagag cggccccggc ctggtgaagc ccagcgagac cctgagcctg       60

acctgcgccg tgagcggcca cagcatcagc cacgaccacg cctggagctg ggtgaggcag      120

ccccccggcg agggcctgga gtggatcggc ttcatcagct acagcggcat caccaactac      180

aaccccagcc tgcagggcag ggtgaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caggagcctg      300

gccaggacca ccgccatgga ctactggggc gagggcaccc tggtgaccgt gagcagcgcc      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg      480

aacagcggcg ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca acttcggcac ccagacctac      600

acctgcaacg tggaccacaa gcccagcaac accaaggtgg acaagaccgt ggagaggaag      660

agctgcgtgg agtgcccccc ctgccccgcc ccccccgtgg ccggc                      705


<210>  33
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  33
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagcgtgacc       60

atcacctgcc aggccagcac cgacatcagc agccacctga actggtacca gcagaagccc      120

ggcaaggccc ccgagctgct gatctactac ggcagccacc tgctgagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccttca ccatcagcag cctggaggcc      240

gaggacgccg ccacctacta ctgcggccag ggcaacaggc tgccctacac cttcggccag      300

ggcaccaagg tggagatcga gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  34
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (661)..(672)
<223>  nucleotids 661 to 672 can be present or absent

<220>
<221>  misc
<222>  (673)..(690)
<223>  nucleotids 673 to 690 can be present or absent

<220>
<221>  misc
<222>  (691)..(723)
<223>  nucleotids 691 to 723 can be present or absent

<400>  34
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcaggag cctgaggctg       60

agctgcgccg ccagcaggtt caccttcgac gactacgcca tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcggc atcagctgga acagcggcag gatcggctac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acgccgagaa cagcctgttc      240

ctgcagatga acggcctgag ggccgaggac accgccctgt actactgcgc caagggcagg      300

gacagcttcg acatctgggg ccagggcacc atggtgaccg tgagcagcgc cagcaccaag      360

ggccccagcg tgttccccct ggcccccagc agcaagagca ccagcggcgg caccgccgcc      420

ctgggctgcc tggtgaagga ctacttcccc gagcccgtga ccgtgagctg gaacagcggc      480

gccctgacca gcggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc      540

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgcgac      660

aagacccaca cctgcccccc ctgccccgcc cccgagctgc tgggcggccc cagcgtgttc      720

ctg                                                                    723


<210>  35
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  35
gacatccaga tgacccagag ccccagcagc gtgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcca gggcatcagc agctggctgg cctggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacggc gccagcagcc tggagagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccagctacta ctgccagcag gccaacagct tcccctacac cttcggccag      300

ggcaccaagc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  36
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (670)..(681)
<223>  nucleotides 670 to 681 can be present or absent

<220>
<221>  misc
<222>  (682)..(699)
<223>  nucleotides 682 to 699 can be present or absent

<220>
<221>  misc
<222>  (700)..(732)
<223>  nucleotides 700 to 732 can be present or absent

<400>  36
gaagtgcagc tggtggaaag cggcggcaaa ctgctgaaac cgggcggcag cctgaaactg       60

agctgcgcgg cgagcggctt tacctttagc agctttgcga tgagctggtt tcgccagagc      120

ccggaaaaac gcctggaatg ggtggcggaa attagcagcg gcggcagcta tacctattat      180

ccggataccg tgaccggccg ctttaccatt agccgcgata acgcgaaaaa caccctgtat      240

ctggaaatga gcagcctgcg cagcgaagat accgcgatgt attattgcgc gcgcggcctg      300

tggggctatt atgcgctgga ttattggggc cagggcacca gcgtgaccgt gagcagcgcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210>  37
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  37
cagattgtgc tgattcagag cccggcgatt atgagcgcga gcccgggcga aaaagtgacc       60

atgacctgca gcgcgagcag cagcgtgagc tatatgtatt ggtatcagca gaaaccgggc      120

agcagcccgc gcctgctgat ttatgatacc agcaacctgg cgagcggcgt gccggtgcgc      180

tttagcggca gcggcagcgg caccagctat agcctgacca ttagccgcat ggaagcggaa      240

gatgcggcga cctattattg ccagcagtgg agcggctatc cgtatacctt tggcggcggc      300

accaaactgg aaattaaacg caccgtggcg gcgccgagcg tgtttatttt tccgccgagc      360

gatgaacagc tgaaaagcgg caccgcgagc gtggtgtgcc tgctgaacaa cttttatccg      420

cgcgaagcga aagtgcagtg gaaagtggat aacgcgctgc agagcggcaa cagccaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccctg      540

agcaaagcgg attatgaaaa acataaagtg tatgcgtgcg aagtgaccca tcagggcctg      600

agcagcccgg tgaccaaaag ctttaaccgc ggcgaatgc                             639


<210>  38
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (673)..(684)
<223>  nucleotides 673 to 684 can be present or absent

<220>
<221>  misc
<222>  (685)..(702)
<223>  nucleotides 685 to 702 can be present or absent

<220>
<221>  misc
<222>  (703)..(735)
<223>  nucleotides 703 to 735 can be present or absent

<400>  38
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tagcctgagc aactattatg tgacctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtgggcatt atttatggca gcgatgaaac cgcgtatgcg      180

accagcgcga ttggccgctt taccattagc cgcgataaca gcaaaaacac cctgtatctg      240

cagatgaaca gcctgcgcgc ggaagatacc gcggtgtatt attgcgcgcg cgatgatagc      300

agcgattggg atgcgaaatt taacctgtgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca aaggcccgag cgtgtttccg ctggcgccga gcagcaaaag caccagcggc      420

ggcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct gcagagcagc      540

ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcagcctggg cacccagacc      600

tatatttgca acgtgaacca taaaccgagc aacaccaaag tggataaacg cgtggaaccg      660

aaaagctgcg ataagaccca cacctgcccc ccctgccccg cccccgagct gctgggcggc      720

cccagcgtgt tcctg                                                       735


<210>  39
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (670)..(681)
<223>  nucleotides 670 to 681 can be present or absent

<220>
<221>  misc
<222>  (682)..(699)
<223>  nucleotides 682 to 699 can be present or absent

<220>
<221>  misc
<222>  (700)..(732)
<223>  nucleotides 700 to 732 can be present or absent

<400>  39
gcgattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc aggcgagcca gagcattaac aacgaactga gctggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttatcgc gcgagcaccc tggcgagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gatgattttg cgacctatta ttgccagcag ggctatagcc tgcgcaacat tgataacgcg      300

tttggcggcg gcaccaaagt ggaaattaaa cgcaccgtgg cggcgccgag cgtgtttatt      360

tttccgccga gcgatgaaca gctgaaaagc ggcaccgcga gcgtggtgtg cctgctgaac      420

aacttttatc cgcgcgaagc gaaagtgcag tggaaagtgg ataacgcgct gcagagcggc      480

aacagccagg aaagcgtgac cgaacaggat agcaaagata gcacctatag cctgagcagc      540

accctgaccc tgagcaaagc ggattatgaa aaacataaag tgtatgcgtg cgaagtgacc      600

catcagggcc tgagcagccc ggtgaccaaa agctttaacc gcggcgaatg cgaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210>  40
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (670)..(681)
<223>  nucleotides 670 to 681 can be present or absent

<220>
<221>  misc
<222>  (682)..(699)
<223>  nucleotides 682 to 699 can be present or absent

<220>
<221>  misc
<222>  (700)..(732)
<223>  nucleotides 700 to 732 can be present or absent

<400>  40
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt tacctttagc ccgtttgcga tgagctgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcgaaa attagcccgg gcggcagctg gacctattat      180

agcgataccg tgaccggccg ctttaccatt agccgcgata acgcgaaaaa cagcctgtat      240

ctgcagatga acagcctgcg cgcggaagat accgcggtgt attattgcgc gcgccagctg      300

tggggctatt atgcgctgga tatttggggc cagggcacca ccgtgaccgt gagcagcgcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210>  41
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  41
gaaattgtgc tgacccagag cccggcgacc ctgagcctga gcccgggcga acgcgcgacc       60

ctgagctgca gcgcgagcat tagcgtgagc tatatgtatt ggtatcagca gaaaccgggc      120

caggcgccgc gcctgctgat ttatgatatg agcaacctgg cgagcggcat tccggcgcgc      180

tttagcggca gcggcagcgg caccgatttt accctgacca ttagcagcct ggaaccggaa      240

gattttgcgg tgtattattg catgcagtgg agcggctatc cgtatacctt tggcggcggc      300

accaaagtgg aaattaaacg caccgtggcg gcgccgagcg tgtttatttt tccgccgagc      360

gatgaacagc tgaaaagcgg caccgcgagc gtggtgtgcc tgctgaacaa cttttatccg      420

cgcgaagcga aagtgcagtg gaaagtggat aacgcgctgc agagcggcaa cagccaggaa      480

agcgtgaccg aacaggatag caaagatagc acctatagcc tgagcagcac cctgaccctg      540

agcaaagcgg attatgaaaa acataaagtg tatgcgtgcg aagtgaccca tcagggcctg      600

agcagcccgg tgaccaaaag ctttaaccgc ggcgaatgc                             639


<210>  42
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (667)..(693)
<223>  nucleotides 667 to 693 can be present or absent

<220>
<221>  misc
<222>  (694)..(726)
<223>  nucleotides 694 to 726 can be present or absent

<400>  42
gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg       60

agctgcgcgg cgagcggctt taactttaac gattatttta tgaactgggt gcgccaggcg      120

ccgggcaaag gcctggaatg ggtggcgcag atgcgcaaca aaaactatca gtatggcacc      180

tattatgcgg aaagcctgga aggccgcttt accattagcc gcgatgatag caaaaacagc      240

ctgtatctgc agatgaacag cctgaaaacc gaagataccg cggtgtatta ttgcgcgcgc      300

gaaagctatt atggctttac cagctattgg ggccagggca ccctggtgac cgtgagcagc      360

gcgagcacca aaggcccgag cgtgtttccg ctggcgccgt gcagccgcag caccagcgaa      420

agcaccgcgg cgctgggctg cctggtgaaa gattattttc cggaaccggt gaccgtgagc      480

tggaacagcg gcgcgctgac cagcggcgtg catacctttc cggcggtgct gcagagcagc      540

ggcctgtata gcctgagcag cgtggtgacc gtgccgagca gcagcctggg caccaaaacc      600

tatacctgca acgtggatca taaaccgagc aacaccaaag tggataaacg cgtggagagc      660

aagtacggcc ccccctgccc cccctgcccc gcccccgagt tcctgggcgg ccccagcgtg      720

ttcctg                                                                 726


<210>  43
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  43
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc aggcgagcca ggatattggc attagcctga gctggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttataac gcgaacaacc tggcggatgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccctga ccattagcag cctgcagccg      240

gaagattttg cgacctatta ttgcctgcag cataacagcg cgccgtatac ctttggccag      300

ggcaccaaac tggaaattaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210>  44
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (679)..(690)
<223>  nucleotides 679 to 690 can be present or absent

<220>
<221>  misc
<222>  (691)..(708)
<223>  nucleotides 691 to 708 can be present or absent

<220>
<221>  misc
<222>  (709)..(741)
<223>  nucleotides 709 to 741 can be present or absent

<400>  44
gaagtgcagc tgcaggaaag cggcccgggc ctggtgaaac cgagccagac cctgagcctg       60

acctgcaccg tgagcggcgg cagcattacc agccgctatt atgcgtggag ctggattcgc      120

cagccgccgg gcaaaggcct ggaatggatt ggcgtgattg attatgatgg cgatacctat      180

tatagcccga gcctgaaaag ccgcgtgagc attagctggg ataccagcaa aaaccagttt      240

agcctgaaac tgagcagcgt gaccccggcg gataccgcgg tgtattattg cgcgcgcgat      300

ccggatgtgg tgaccggctt tcattatgat tattggggcc agggcaccat ggtgaccgtg      360

agcagcgcga gcaccaaagg cccgagcgtg tttccgctgg cgccgagcag caaaagcacc      420

agcggcggca ccgcggcgct gggctgcctg gtgaaagatt attttccgga accggtgacc      480

gtgagctgga acagcggcgc gctgaccagc ggcgtgcata cctttccggc ggtgctgcag      540

agcagcggcc tgtatagcct gagcagcgtg gtgaccgtgc cgagcagcag cctgggcacc      600

cagacctata tttgcaacgt gaaccataaa ccgagcaaca ccaaagtgga taaaaaagtg      660

gaaccgaaaa gctgcgataa gacccacacc tgccccccct gccccgcccc cgagctgctg      720

ggcggcccca gcgtgttcct g                                                741


<210>  45
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  45
cagagcgcgc tgacccagcc gccgagcgtg agcggcaccc cgggccagag cgtgaccatt       60

agctgcgcgg gcgcgaacaa cgatattggc acctatgcgt atgtgagctg gtatcagcag      120

ctgccgggca ccgcgccgaa actgatgatt tataaagtga ccacccgcgc gagcggcatt      180

ccggatcgct ttagcggcag caaaagcggc aacaccgcga gcctgaccat tagcggcctg      240

caggcggaag atgaagcgga ttattattgc gcgagctatc gcaactttaa caacgcggtg      300

tttggcaccg gcaccaaact gaccgtgctg ggccagccga aagcggcgcc gagcgtgacc      360

ctgtttccgc cgagcagcga agaactgcag gcgaacaaag cgaccctggt gtgcctgatt      420

agcgattttt atccgggcgc ggtgaccgtg gcgtggaaag cggatagcag cccggtgaaa      480

gcgggcgtgg aaaccaccac cccgagcaaa cagagcaaca acaaatatgc ggcgagcagc      540

tatctgagcc tgaccccgga acagtggaaa agccatcgca gctatagctg ccaggtgacc      600

catgaaggca gcaccgtgga aaaaaccgtg gcgccgaccg aatgcagc                   648


<210>  46
<211>  4513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  46
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct     1980

ggccctggtc accaattctg aagtgcagct ggtggaaagt ggtggtggac tggtgcagcc     2040

tggcagaagc ctgagactgt cttgtgctgc ctctggcttc acctttgatg actatgccat     2100

gcactgggtc agacaggccc ctggcaaagg actggaatgg gtgtcagcca tcacctggaa     2160

ctctggccac attgactatg ctgactctgt ggaaggcaga ttcaccatca gcagagacaa     2220

tgccaagaac agcctgtacc tgcagatgaa ctccctgaga gctgaggaca cagcagtgta     2280

ctactgtgcc aaggtgtcct acctgagcac agccagcagc ctggattatt ggggccaggg     2340

cacactggtt acagtgtcct ctgccagcac aaagggcccc tctgtttttc cactggctcc     2400

cagcagcaag agcaccagtg gtggaacagc tgccctgggc tgtctggtca aggattactt     2460

ccctgagcct gtgacagtgt cttggaactc aggggctctg acctctgggg tgcacacatt     2520

tccagctgtg ctgcagtcct ctggcctgta ctctctgtcc tctgtggtca cagtgcctag     2580

ctctagcctg ggcacccaga cctacatctg caatgtgaac cacaagccta gcaacaccaa     2640

ggtggacaag aaggtggaac ccaagagctg tgacaagacc cacacctgtc ctccatgtcc     2700

tgctccagaa ctgcttggag gcccttctgt gttcctgttt cctccaaagc ctaaggacac     2760

cctgatgatc agcagaaccc ctgaagtgac ctgtgtggtg gttgatgtgt cccatgagga     2820

cccagaagtg aagttcaatt ggtatgtgga tggggttgaa gtgcacaatg ctaagaccaa     2880

gcctagagag gaacagtaca acagcaccta cagagtggtg tctgtgctga cagtgctgca     2940

tcaggactgg ctgaatggca aagagtacaa gtgcaaagtg tccaacaagg ccctgcctgc     3000

tcctattgag aaaaccatct ccaaggccaa gggccagcca agagaacccc aggtttacac     3060

actgccacct agcagagatg agctgaccaa gaaccaggtg tccctgacct gcctggttaa     3120

gggcttctac ccctctgaca ttgctgtgga atgggagagc aatggccagc ctgagaacaa     3180

ctacaagaca acccctcctg tgctggactc tgatggctca ttcttcctgt acagcaagct     3240

gactgtggac aagtccagat ggcagcaggg gaatgtgttc agctgctctg tgatgcatga     3300

ggccctgcac aaccactaca cccagaaaag tctgagtctg agccctggca agagaaagag     3360

aagaggctct ggagaaggca gaggctccct gctgacatgt ggggatgttg aagagaatcc     3420

tgggcctatg tataggatgc aactgctcct cctgattgct ctgagcctgg ctcttgtgac     3480

caactctgac atccagatga cacagagccc tagcagcctg tctgcttctg tgggagacag     3540

agtgaccatc acatgcagag ccagccaggg aatcagaaac tacctggcct ggtatcagca     3600

aaagcctggc aaggccccta agctgctgat ctatgcagcc agcacactgc agtcaggggt     3660

gccaagcaga ttttcaggct ctggctctgg cacagacttc accctgacca tttctagcct     3720

gcagcctgag gatgtggcca cctactactg ccagagatac aacagagccc catacacctt     3780

tggacagggc acaaaggtgg aaatcaagag aacagtggct gccccatctg tgttcatctt     3840

cccaccatct gatgaacagc tgaagtctgg cactgcctct gttgtgtgcc tgctgaacaa     3900

cttctaccct agagaagcca aggtgcagtg gaaggttgac aatgccctgc agtctggcaa     3960

tagccaagaa tctgtgacag agcaggactc caaggattcc acctacagcc tgagcagcac     4020

cctgacactg agcaaggctg actatgagaa gcacaaagtg tatgcctgtg aagtgacaca     4080

ccagggactg agcagcccag tgaccaagag cttcaacagg ggagagtgct gataactcga     4140

ggacggggtg aactacgcct gaggatccga tctttttccc tctgccaaaa attatgggga     4200

catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta ttttcattgc     4260

aatagtgtgt tggaattttt tgtgtctctc actcggaagc aattcgttga tctgaatttc     4320

gaccacccat aatacccatt accctggtag ataagtagca tggcgggtta atcattaact     4380

acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     4440

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     4500

agcgagcgcg cag                                                        4513


<210>  47
<211>  4092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  47
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccaccatgt     1740

acagaatgca gctgctgctg ctcattgccc tgtctctggc cctggtcacc aattctgaag     1800

tgcagctggt ggaaagtggt ggtggactgg tgcagcctgg cagaagcctg agactgtctt     1860

gtgctgcctc tggcttcacc tttgatgact atgccatgca ctgggtcaga caggcccctg     1920

gcaaaggact ggaatgggtg tcagccatca cctggaactc tggccacatt gactatgctg     1980

actctgtgga aggcagattc accatcagca gagacaatgc caagaacagc ctgtacctgc     2040

agatgaactc cctgagagct gaggacacag cagtgtacta ctgtgccaag gtgtcctacc     2100

tgagcacagc cagcagcctg gattattggg gccagggcac actggttaca gtgtcctctg     2160

ccagcacaaa gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg     2220

gaacagctgc cctgggctgt ctggtcaagg attacttccc tgagcctgtg acagtgtctt     2280

ggaactcagg ggctctgacc tctggggtgc acacatttcc agctgtgctg cagtcctctg     2340

gcctgtactc tctgtcctct gtggtcacag tgcctagctc tagcctgggc acccagacct     2400

acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag gtggaaccca     2460

agagctgtga caagacccac acctgtcctc catgtcctgc tccagaactg cttggaggcc     2520

cttctgtgtt cctgtttcct ccaaagccta aggacaccct gatgatcagc agaacccctg     2580

aagtgacctg tgtggtggtt gatgtgtccc atgaggaccc agaagtgaag ttcaattggt     2640

atgtggatgg ggttgaagtg cacaatgcta agaccaagcc tagagaggaa cagtacaaca     2700

gcacctacag agtggtgtct gtgctgacag tgctgcatca ggactggctg aatggcaaag     2760

agtacaagtg caaagtgtcc aacaaggccc tgcctgctcc tattgagaaa accatctcca     2820

aggccaaggg ccagccaaga gaaccccagg tttacacact gccacctagc agagatgagc     2880

tgaccaagaa ccaggtgtcc ctgacctgcc tggttaaggg cttctacccc tctgacattg     2940

ctgtggaatg ggagagcaat ggccagcctg agaacaacta caagacaacc cctcctgtgc     3000

tggactctga tggctcattc ttcctgtaca gcaagctgac tgtggacaag tccagatggc     3060

agcaggggaa tgtgttcagc tgctctgtga tgcatgaggc cctgcacaac cactacaccc     3120

agaaaagtct gagtctgagc cctggcaaga gaaagagaag aggctctgga gaaggcagag     3180

gctccctgct gacatgtggg gatgttgaag agaatcctgg gcctatgtat aggatgcaac     3240

tgctcctcct gattgctctg agcctggctc ttgtgaccaa ctctgacatc cagatgacac     3300

agagccctag cagcctgtct gcttctgtgg gagacagagt gaccatcaca tgcagagcca     3360

gccagggaat cagaaactac ctggcctggt atcagcaaaa gcctggcaag gcccctaagc     3420

tgctgatcta tgcagccagc acactgcagt caggggtgcc aagcagattt tcaggctctg     3480

gctctggcac agacttcacc ctgaccattt ctagcctgca gcctgaggat gtggccacct     3540

actactgcca gagatacaac agagccccat acacctttgg acagggcaca aaggtggaaa     3600

tcaagagaac agtggctgcc ccatctgtgt tcatcttccc accatctgat gaacagctga     3660

agtctggcac tgcctctgtt gtgtgcctgc tgaacaactt ctaccctaga gaagccaagg     3720

tgcagtggaa ggttgacaat gccctgcagt ctggcaatag ccaagaatct gtgacagagc     3780

aggactccaa ggattccacc tacagcctga gcagcaccct gacactgagc aaggctgact     3840

atgagaagca caaagtgtat gcctgtgaag tgacacacca gggactgagc agcccagtga     3900

ccaagagctt caacagggga gagtgctgat aactcgagga cggggtgaac tacgcctgag     3960

gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4020

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4080

gtctctcact cg                                                         4092


<210>  48
<211>  2193
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  48
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg      120

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      180

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      240

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      360

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      420

tctgccagca caaagggccc ctctgttttt ccactggctc ccagcagcaa gagcaccagt      480

ggtggaacag ctgccctggg ctgtctggtc aaggattact tccctgagcc tgtgacagtg      540

tcttggaact caggggctct gacctctggg gtgcacacat ttccagctgt gctgcagtcc      600

tctggcctgt actctctgtc ctctgtggtc acagtgccta gctctagcct gggcacccag      660

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      720

cccaagagct gtgacaagac ccacacctgt cctccatgtc ctgctccaga actgcttgga      780

ggcccttctg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc      840

cctgaagtga cctgtgtggt ggttgatgtg tcccatgagg acccagaagt gaagttcaat      900

tggtatgtgg atggggttga agtgcacaat gctaagacca agcctagaga ggaacagtac      960

aacagcacct acagagtggt gtctgtgctg acagtgctgc atcaggactg gctgaatggc     1020

aaagagtaca agtgcaaagt gtccaacaag gccctgcctg ctcctattga gaaaaccatc     1080

tccaaggcca agggccagcc aagagaaccc caggtttaca cactgccacc tagcagagat     1140

gagctgacca agaaccaggt gtccctgacc tgcctggtta agggcttcta cccctctgac     1200

attgctgtgg aatgggagag caatggccag cctgagaaca actacaagac aacccctcct     1260

gtgctggact ctgatggctc attcttcctg tacagcaagc tgactgtgga caagtccaga     1320

tggcagcagg ggaatgtgtt cagctgctct gtgatgcatg aggccctgca caaccactac     1380

acccagaaaa gtctgagtct gagccctggc aagagaaaga gaagaggctc tggagaaggc     1440

agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg     1500

caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg     1560

acacagagcc ctagcagcct gtctgcttct gtgggagaca gagtgaccat cacatgcaga     1620

gccagccagg gaatcagaaa ctacctggcc tggtatcagc aaaagcctgg caaggcccct     1680

aagctgctga tctatgcagc cagcacactg cagtcagggg tgccaagcag attttcaggc     1740

tctggctctg gcacagactt caccctgacc atttctagcc tgcagcctga ggatgtggcc     1800

acctactact gccagagata caacagagcc ccatacacct ttggacaggg cacaaaggtg     1860

gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag     1920

ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc     1980

aaggtgcagt ggaaggttga caatgccctg cagtctggca atagccaaga atctgtgaca     2040

gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct     2100

gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact gagcagccca     2160

gtgaccaaga gcttcaacag gggagagtgc tga                                  2193


<210>  49
<211>  3844
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  49
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct     1980

ggccctggtc accaattctg aagtgcagct ggtggaaagt ggtggtggac tggtgcagcc     2040

tggcagaagc ctgagactgt cttgtgctgc ctctggcttc acctttgatg actatgccat     2100

gcactgggtc agacaggccc ctggcaaagg actggaatgg gtgtcagcca tcacctggaa     2160

ctctggccac attgactatg ctgactctgt ggaaggcaga ttcaccatca gcagagacaa     2220

tgccaagaac agcctgtacc tgcagatgaa ctccctgaga gctgaggaca cagcagtgta     2280

ctactgtgcc aaggtgtcct acctgagcac agccagcagc ctggattatt ggggccaggg     2340

cacactggtt acagtgtcct ctgccagcac aaagggcccc tctgtttttc cactggctcc     2400

cagcagcaag agcaccagtg gtggaacagc tgccctgggc tgtctggtca aggattactt     2460

ccctgagcct gtgacagtgt cttggaactc aggggctctg acctctgggg tgcacacatt     2520

tccagctgtg ctgcagtcct ctggcctgta ctctctgtcc tctgtggtca cagtgcctag     2580

ctctagcctg ggcacccaga cctacatctg caatgtgaac cacaagccta gcaacaccaa     2640

ggtggacaag aaggtggaac ccaagagctg tgacaagacc cacagaaaga gaagaggctc     2700

tggagaaggc agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat     2760

gtataggatg caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga     2820

catccagatg acacagagcc ctagcagcct gtctgcttct gtgggagaca gagtgaccat     2880

cacatgcaga gccagccagg gcatcagaaa ctacctggcc tggtatcagc agaagccagg     2940

caaggcccct aagctgctga tctatgcagc cagcacactg cagagtgggg tgccaagcag     3000

attttcaggc tctggctctg gcacagactt caccctgacc atttctagcc tgcagcctga     3060

ggatgtggcc acctactact gccagagata caacagagcc ccatacacct ttggacaggg     3120

cacaaaggtg gaaatcaaga gaacagttgc agcaccctca gttttcatct tccccccctc     3180

agatgaacag ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca acttctaccc     3240

cagagaagcc aaggtgcagt ggaaggttga caatgccctg cagtcaggca acagccaaga     3300

atctgtgact gaacaggatt ccaaggatag cacctacagc ctgagcagca ccctgacact     3360

gagcaaggct gactatgaga agcacaaagt gtatgcctgt gaagtgaccc accagggact     3420

gagcagccca gtgaccaaga gcttcaacag gggagagtgc tgataactcg aggacggggt     3480

gaactacgcc tgaggatccg atctttttcc ctctgccaaa aattatgggg acatcatgaa     3540

gccccttgag catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg     3600

ttggaatttt ttgtgtctct cactcggaag caattcgttg atctgaattt cgaccaccca     3660

taatacccat taccctggta gataagtagc atggcgggtt aatcattaac tacaaggaac     3720

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     3780

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     3840

gcag                                                                  3844


<210>  50
<211>  3423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  50
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaagaattc gccaccatgt     1740

acagaatgca gctgctgctg ctcattgccc tgtctctggc cctggtcacc aattctgaag     1800

tgcagctggt ggaaagtggt ggtggactgg tgcagcctgg cagaagcctg agactgtctt     1860

gtgctgcctc tggcttcacc tttgatgact atgccatgca ctgggtcaga caggcccctg     1920

gcaaaggact ggaatgggtg tcagccatca cctggaactc tggccacatt gactatgctg     1980

actctgtgga aggcagattc accatcagca gagacaatgc caagaacagc ctgtacctgc     2040

agatgaactc cctgagagct gaggacacag cagtgtacta ctgtgccaag gtgtcctacc     2100

tgagcacagc cagcagcctg gattattggg gccagggcac actggttaca gtgtcctctg     2160

ccagcacaaa gggcccctct gtttttccac tggctcccag cagcaagagc accagtggtg     2220

gaacagctgc cctgggctgt ctggtcaagg attacttccc tgagcctgtg acagtgtctt     2280

ggaactcagg ggctctgacc tctggggtgc acacatttcc agctgtgctg cagtcctctg     2340

gcctgtactc tctgtcctct gtggtcacag tgcctagctc tagcctgggc acccagacct     2400

acatctgcaa tgtgaaccac aagcctagca acaccaaggt ggacaagaag gtggaaccca     2460

agagctgtga caagacccac agaaagagaa gaggctctgg agaaggcaga ggctccctgc     2520

tgacatgtgg ggatgttgaa gagaatcctg ggcctatgta taggatgcaa ctgctcctcc     2580

tgattgctct gagcctggct cttgtgacca actctgacat ccagatgaca cagagcccta     2640

gcagcctgtc tgcttctgtg ggagacagag tgaccatcac atgcagagcc agccagggca     2700

tcagaaacta cctggcctgg tatcagcaga agccaggcaa ggcccctaag ctgctgatct     2760

atgcagccag cacactgcag agtggggtgc caagcagatt ttcaggctct ggctctggca     2820

cagacttcac cctgaccatt tctagcctgc agcctgagga tgtggccacc tactactgcc     2880

agagatacaa cagagcccca tacacctttg gacagggcac aaaggtggaa atcaagagaa     2940

cagttgcagc accctcagtt ttcatcttcc ccccctcaga tgaacagctg aagtctggca     3000

ctgcctctgt tgtgtgcctg ctgaacaact tctaccccag agaagccaag gtgcagtgga     3060

aggttgacaa tgccctgcag tcaggcaaca gccaagaatc tgtgactgaa caggattcca     3120

aggatagcac ctacagcctg agcagcaccc tgacactgag caaggctgac tatgagaagc     3180

acaaagtgta tgcctgtgaa gtgacccacc agggactgag cagcccagtg accaagagct     3240

tcaacagggg agagtgctga taactcgagg acggggtgaa ctacgcctga ggatccgatc     3300

tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg     3360

gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac     3420

tcg                                                                   3423


<210>  51
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  51
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg      120

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      180

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      240

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      300

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      360

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      420

tctgccagca caaagggccc ctctgttttt ccactggctc ccagcagcaa gagcaccagt      480

ggtggaacag ctgccctggg ctgtctggtc aaggattact tccctgagcc tgtgacagtg      540

tcttggaact caggggctct gacctctggg gtgcacacat ttccagctgt gctgcagtcc      600

tctggcctgt actctctgtc ctctgtggtc acagtgccta gctctagcct gggcacccag      660

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      720

cccaagagct gtgacaagac ccacagaaag agaagaggct ctggagaagg cagaggctcc      780

ctgctgacat gtggggatgt tgaagagaat cctgggccta tgtataggat gcaactgctc      840

ctcctgattg ctctgagcct ggctcttgtg accaactctg acatccagat gacacagagc      900

cctagcagcc tgtctgcttc tgtgggagac agagtgacca tcacatgcag agccagccag      960

ggcatcagaa actacctggc ctggtatcag cagaagccag gcaaggcccc taagctgctg     1020

atctatgcag ccagcacact gcagagtggg gtgccaagca gattttcagg ctctggctct     1080

ggcacagact tcaccctgac catttctagc ctgcagcctg aggatgtggc cacctactac     1140

tgccagagat acaacagagc cccatacacc tttggacagg gcacaaaggt ggaaatcaag     1200

agaacagttg cagcaccctc agttttcatc ttccccccct cagatgaaca gctgaagtct     1260

ggcactgcct ctgttgtgtg cctgctgaac aacttctacc ccagagaagc caaggtgcag     1320

tggaaggttg acaatgccct gcagtcaggc aacagccaag aatctgtgac tgaacaggat     1380

tccaaggata gcacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag     1440

aagcacaaag tgtatgcctg tgaagtgacc caccagggac tgagcagccc agtgaccaag     1500

agcttcaaca ggggagagtg ctga                                            1524


<210>  52
<211>  3159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  52
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg      240

cggccccttg gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg      300

gattgtcttt ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg      360

atttagcctg gtgctgtgtc agccccgggc tcccaggggc ttcccagtgg tccccaggaa      420

ccctcgacag ggccagggcg tctctctcgt ccagcaaggg cagggacggg ccacaggcca      480

agggccaggt gagtatctca gggatccaga catggggata tgggaggtgc ctctgatccc      540

agggctcact gtgggtctct ctgttcacag gttgaattcg ccaccatgta cagaatgcag      600

ctgctgctgc tcattgccct gtctctggcc ctggtcacca attctgaagt gcagctggtg      660

gaaagtggtg gtggactggt gcagcctggc agaagcctga gactgtcttg tgctgcctct      720

ggcttcacct ttgatgacta tgccatgcac tgggtcagac aggcccctgg caaaggactg      780

gaatgggtgt cagccatcac ctggaactct ggccacattg actatgctga ctctgtggaa      840

ggcagattca ccatcagcag agacaatgcc aagaacagcc tgtacctgca gatgaactcc      900

ctgagagctg aggacacagc agtgtactac tgtgccaagg tgtcctacct gagcacagcc      960

agcagcctgg attattgggg ccagggcaca ctggttacag tgtcctctgc cagcacaaag     1020

ggcccctctg tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc     1080

ctgggctgtc tggtcaagga ttacttccct gagcctgtga cagtgtcttg gaactcaggg     1140

gctctgacct ctggggtgca cacatttcca gctgtgctgc agtcctctgg cctgtactct     1200

ctgtcctctg tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat     1260

gtgaaccaca agcctagcaa caccaaggtg gacaagaagg tggaacccaa gagctgtgac     1320

aagacccaca cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc     1380

ctgtttcctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt     1440

gtggtggttg atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg     1500

gttgaagtgc acaatgctaa gaccaagcct agagaggaac agtacaacag cacctacaga     1560

gtggtgtctg tgctgacagt gctgcatcag gactggctga atggcaaaga gtacaagtgc     1620

aaagtgtcca acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggc     1680

cagccaagag aaccccaggt ttacacactg ccacctagca gagatgagct gaccaagaac     1740

caggtgtccc tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg     1800

gagagcaatg gccagcctga gaacaactac aagacaaccc ctcctgtgct ggactctgat     1860

ggctcattct tcctgtacag caagctgact gtggacaagt ccagatggca gcaggggaat     1920

gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagtctg     1980

agtctgagcc ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg     2040

acatgtgggg atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg     2100

attgctctga gcctggctct tgtgaccaac tctgacatcc agatgacaca gagccctagc     2160

agcctgtctg cttctgtggg agacagagtg accatcacat gcagagccag ccagggaatc     2220

agaaactacc tggcctggta tcagcaaaag cctggcaagg cccctaagct gctgatctat     2280

gcagccagca cactgcagtc aggggtgcca agcagatttt caggctctgg ctctggcaca     2340

gacttcaccc tgaccatttc tagcctgcag cctgaggatg tggccaccta ctactgccag     2400

agatacaaca gagccccata cacctttgga cagggcacaa aggtggaaat caagagaaca     2460

gtggctgccc catctgtgtt catcttccca ccatctgatg aacagctgaa gtctggcact     2520

gcctctgttg tgtgcctgct gaacaacttc taccctagag aagccaaggt gcagtggaag     2580

gttgacaatg ccctgcagtc tggcaatagc caagaatctg tgacagagca ggactccaag     2640

gattccacct acagcctgag cagcaccctg acactgagca aggctgacta tgagaagcac     2700

aaagtgtatg cctgtgaagt gacacaccag ggactgagca gcccagtgac caagagcttc     2760

aacaggggag agtgctgata actcgaggac ggggtgaact acgcctgagg atccgatctt     2820

tttccctctg ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc     2880

taataaagga aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc     2940

ggaagcaatt cgttgatctg aatttcgacc acccataata cccattaccc tggtagataa     3000

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     3060

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     3120

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                            3159


<210>  53
<211>  2751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  53
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccgggc tcccaggggc ttcccagtgg tccccaggaa ccctcgacag      240

ggccagggcg tctctctcgt ccagcaaggg cagggacggg ccacaggcca agggccaggt      300

gagtatctca gggatccaga catggggata tgggaggtgc ctctgatccc agggctcact      360

gtgggtctct ctgttcacag gttgaattcg ccaccatgta cagaatgcag ctgctgctgc      420

tcattgccct gtctctggcc ctggtcacca attctgaagt gcagctggtg gaaagtggtg      480

gtggactggt gcagcctggc agaagcctga gactgtcttg tgctgcctct ggcttcacct      540

ttgatgacta tgccatgcac tgggtcagac aggcccctgg caaaggactg gaatgggtgt      600

cagccatcac ctggaactct ggccacattg actatgctga ctctgtggaa ggcagattca      660

ccatcagcag agacaatgcc aagaacagcc tgtacctgca gatgaactcc ctgagagctg      720

aggacacagc agtgtactac tgtgccaagg tgtcctacct gagcacagcc agcagcctgg      780

attattgggg ccagggcaca ctggttacag tgtcctctgc cagcacaaag ggcccctctg      840

tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc ctgggctgtc      900

tggtcaagga ttacttccct gagcctgtga cagtgtcttg gaactcaggg gctctgacct      960

ctggggtgca cacatttcca gctgtgctgc agtcctctgg cctgtactct ctgtcctctg     1020

tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat gtgaaccaca     1080

agcctagcaa caccaaggtg gacaagaagg tggaacccaa gagctgtgac aagacccaca     1140

cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc ctgtttcctc     1200

caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt gtggtggttg     1260

atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg gttgaagtgc     1320

acaatgctaa gaccaagcct agagaggaac agtacaacag cacctacaga gtggtgtctg     1380

tgctgacagt gctgcatcag gactggctga atggcaaaga gtacaagtgc aaagtgtcca     1440

acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggc cagccaagag     1500

aaccccaggt ttacacactg ccacctagca gagatgagct gaccaagaac caggtgtccc     1560

tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg gagagcaatg     1620

gccagcctga gaacaactac aagacaaccc ctcctgtgct ggactctgat ggctcattct     1680

tcctgtacag caagctgact gtggacaagt ccagatggca gcaggggaat gtgttcagct     1740

gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagtctg agtctgagcc     1800

ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg acatgtgggg     1860

atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg attgctctga     1920

gcctggctct tgtgaccaac tctgacatcc agatgacaca gagccctagc agcctgtctg     1980

cttctgtggg agacagagtg accatcacat gcagagccag ccagggaatc agaaactacc     2040

tggcctggta tcagcaaaag cctggcaagg cccctaagct gctgatctat gcagccagca     2100

cactgcagtc aggggtgcca agcagatttt caggctctgg ctctggcaca gacttcaccc     2160

tgaccatttc tagcctgcag cctgaggatg tggccaccta ctactgccag agatacaaca     2220

gagccccata cacctttgga cagggcacaa aggtggaaat caagagaaca gtggctgccc     2280

catctgtgtt catcttccca ccatctgatg aacagctgaa gtctggcact gcctctgttg     2340

tgtgcctgct gaacaacttc taccctagag aagccaaggt gcagtggaag gttgacaatg     2400

ccctgcagtc tggcaatagc caagaatctg tgacagagca ggactccaag gattccacct     2460

acagcctgag cagcaccctg acactgagca aggctgacta tgagaagcac aaagtgtatg     2520

cctgtgaagt gacacaccag ggactgagca gcccagtgac caagagcttc aacaggggag     2580

agtgctgata actcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg     2640

ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga     2700

aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc g              2751


<210>  54
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  54
gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg       60

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      180

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      240

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      300

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      360

tctgccagca caaagggccc ctctgttttt ccactggctc ccagcagcaa gagcaccagt      420

ggtggaacag ctgccctggg ctgtctggtc aaggattact tccctgagcc tgtgacagtg      480

tcttggaact caggggctct gacctctggg gtgcacacat ttccagctgt gctgcagtcc      540

tctggcctgt actctctgtc ctctgtggtc acagtgccta gctctagcct gggcacccag      600

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      660

cccaagagct gtgacaagac ccacacctgt cctccatgtc ctgctccaga actgcttgga      720

ggcccttctg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc      780

cctgaagtga cctgtgtggt ggttgatgtg tcccatgagg acccagaagt gaagttcaat      840

tggtatgtgg atggggttga agtgcacaat gctaagacca agcctagaga ggaacagtac      900

aacagcacct acagagtggt gtctgtgctg acagtgctgc atcaggactg gctgaatggc      960

aaagagtaca agtgcaaagt gtccaacaag gccctgcctg ctcctattga gaaaaccatc     1020

tccaaggcca agggccagcc aagagaaccc caggtttaca cactgccacc tagcagagat     1080

gagctgacca agaaccaggt gtccctgacc tgcctggtta agggcttcta cccctctgac     1140

attgctgtgg aatgggagag caatggccag cctgagaaca actacaagac aacccctcct     1200

gtgctggact ctgatggctc attcttcctg tacagcaagc tgactgtgga caagtccaga     1260

tggcagcagg ggaatgtgtt cagctgctct gtgatgcatg aggccctgca caaccactac     1320

acccagaaaa gtctgagtct gagccctggc aag                                  1353


<210>  55
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  55
gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc ctggcagaag cctgagactg       60

tcttgtgctg cctctggctt cacctttgat gactatgcca tgcactgggt cagacaggcc      120

cctggcaaag gactggaatg ggtgtcagcc atcacctgga actctggcca cattgactat      180

gctgactctg tggaaggcag attcaccatc agcagagaca atgccaagaa cagcctgtac      240

ctgcagatga actccctgag agctgaggac acagcagtgt actactgtgc caaggtgtcc      300

tacctgagca cagccagcag cctggattat tggggccagg gcacactggt tacagtgtcc      360

tct                                                                    363


<210>  56
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  56
gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag caccagtggt       60

ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt gacagtgtct      120

tggaactcag gggctctgac ctctggggtg cacacatttc cagctgtgct gcagtcctct      180

ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg cacccagacc      240

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagaa ggtg            294


<210>  57
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  57
gctccagaac tgcttggagg cccttctgtg ttcctgtttc ctccaaagcc taaggacacc       60

ctgatgatca gcagaacccc tgaagtgacc tgtgtggtgg ttgatgtgtc ccatgaggac      120

ccagaagtga agttcaattg gtatgtggat ggggttgaag tgcacaatgc taagaccaag      180

cctagagagg aacagtacaa cagcacctac agagtggtgt ctgtgctgac agtgctgcat      240

caggactggc tgaatggcaa agagtacaag tgcaaagtgt ccaacaaggc cctgcctgct      300

cctattgaga aaaccatctc caaggccaag ggccagccaa gagaacccca ggtttacaca      360

ctgccaccta gcagagatga gctgaccaag aaccaggtgt ccctgacctg cctggttaag      420

ggcttctacc cctctgacat tgctgtggaa tgggagagca atggccagcc tgagaacaac      480

tacaagacaa cccctcctgt gctggactct gatggctcat tcttcctgta cagcaagctg      540

actgtggaca agtccagatg gcagcagggg aatgtgttca gctgctctgt gatgcatgag      600

gccctgcaca accactacac ccagaaaagt ctgagtctga gccctggcaa g               651


<210>  58
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  58
gctccagaac tgcttggagg cccttctgtg ttcctgtttc ctccaaagcc taaggacacc       60

ctgatgatca gcagaacccc tgaagtgacc tgtgtggtgg ttgatgtgtc ccatgaggac      120

ccagaagtga agttcaattg gtatgtggat ggggttgaag tgcacaatgc taagaccaag      180

cctagagagg aacagtacaa cagcacctac agagtggtgt ctgtgctgac agtgctgcat      240

caggactggc tgaatggcaa agagtacaag tgcaaagtgt ccaacaaggc cctgcctgct      300

cctattgaga aaaccatctc caaggccaag ggccagccaa gagaacccca ggtttacaca      360

ctgccaccta gcagagatga gctgaccaag aaccaggtgt ccctgacctg cctggttaag      420

ggcttctacc cctctgacat tgctgtggaa tgggagagca atggccagcc tgagaacaac      480

tacaagacaa cccctcctgt gctggactct gatggctcat tcttcctgta cagcaagctg      540

actgtggaca agtccagatg gcagcagggg aatgtgttca gctgctctgt gatgcatgag      600

gccctgcaca accactacac ccagaaaagt ctgagtctga gccctggcaa g               651


<210>  59
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  59
gacatccaga tgacacagag ccctagcagc ctgtctgctt ctgtgggaga cagagtgacc       60

atcacatgca gagccagcca gggaatcaga aactacctgg cctggtatca gcaaaagcct      120

ggcaaggccc ctaagctgct gatctatgca gccagcacac tgcagtcagg ggtgccaagc      180

agattttcag gctctggctc tggcacagac ttcaccctga ccatttctag cctgcagcct      240

gaggatgtgg ccacctacta ctgccagaga tacaacagag ccccatacac ctttggacag      300

ggcacaaagg tggaaatcaa g                                                321


<210>  60
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  60
agaacagttg cagcaccctc agttttcatc ttccccccct cagatgaaca gctgaagtct       60

ggcactgcct ctgttgtgtg cctgctgaac aacttctacc ccagagaagc caaggtgcag      120

tggaaggttg acaatgccct gcagtcaggc aacagccaag aatctgtgac tgaacaggat      180

tccaaggata gcacctacag cctgagcagc accctgacac tgagcaaggc tgactatgag      240

aagcacaaag tgtatgcctg tgaagtgacc caccagggac tgagcagccc agtgaccaag      300

agcttcaaca ggggagagtg ctga                                             324


<210>  61
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  61

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  62
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  62

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  63
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  63

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210>  64
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  64

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  65
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  65

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  66
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  66

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  67
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  67

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Ala 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        195                 200             


<210>  68
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  68

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  69
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  69

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  70
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  70

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  71
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  71

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210>  72
<211>  204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment

<400>  72

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        195                 200                 


<210>  73
<211>  1725
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  73

Gly Ala Cys Ala Thr Thr Gly Ala Thr Thr Ala Thr Thr Gly Ala Cys 
1               5                   10                  15      


Thr Ala Gly Thr Thr Ala Thr Thr Ala Ala Thr Ala Gly Thr Ala Ala 
            20                  25                  30          


Thr Cys Ala Ala Thr Thr Ala Cys Gly Gly Gly Gly Thr Cys Ala Thr 
        35                  40                  45              


Thr Ala Gly Thr Thr Cys Ala Thr Ala Gly Cys Cys Cys Ala Thr Ala 
    50                  55                  60                  


Thr Ala Thr Gly Gly Ala Gly Thr Thr Cys Cys Gly Cys Gly Thr Thr 
65                  70                  75                  80  


Ala Cys Ala Thr Ala Ala Cys Thr Thr Ala Cys Gly Gly Thr Ala Ala 
                85                  90                  95      


Ala Thr Gly Gly Cys Cys Cys Gly Cys Cys Thr Gly Gly Cys Thr Gly 
            100                 105                 110         


Ala Cys Cys Gly Cys Cys Cys Ala Ala Cys Gly Ala Cys Cys Cys Cys 
        115                 120                 125             


Cys Gly Cys Cys Cys Ala Thr Thr Gly Ala Cys Gly Thr Cys Ala Ala 
    130                 135                 140                 


Thr Ala Ala Thr Gly Ala Cys Gly Thr Ala Thr Gly Thr Thr Cys Cys 
145                 150                 155                 160 


Cys Ala Thr Ala Gly Thr Ala Ala Cys Gly Cys Cys Ala Ala Thr Ala 
                165                 170                 175     


Gly Gly Gly Ala Cys Thr Thr Thr Cys Cys Ala Thr Thr Gly Ala Cys 
            180                 185                 190         


Gly Thr Cys Ala Ala Thr Gly Gly Gly Thr Gly Gly Ala Gly Thr Ala 
        195                 200                 205             


Thr Thr Thr Ala Cys Gly Gly Thr Ala Ala Ala Cys Thr Gly Cys Cys 
    210                 215                 220                 


Cys Ala Cys Thr Thr Gly Gly Cys Ala Gly Thr Ala Cys Ala Thr Cys 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Thr Ala Thr Cys Ala Thr Ala Thr Gly Cys Cys 
                245                 250                 255     


Ala Ala Gly Thr Ala Cys Gly Cys Cys Cys Cys Cys Thr Ala Thr Thr 
            260                 265                 270         


Gly Ala Cys Gly Thr Cys Ala Ala Thr Gly Ala Cys Gly Gly Thr Ala 
        275                 280                 285             


Ala Ala Thr Gly Gly Cys Cys Cys Gly Cys Cys Thr Gly Gly Cys Ala 
    290                 295                 300                 


Thr Thr Ala Thr Gly Cys Cys Cys Ala Gly Thr Ala Cys Ala Thr Gly 
305                 310                 315                 320 


Ala Cys Cys Thr Thr Ala Thr Gly Gly Gly Ala Cys Thr Thr Thr Cys 
                325                 330                 335     


Cys Thr Ala Cys Thr Thr Gly Gly Cys Ala Gly Thr Ala Cys Ala Thr 
            340                 345                 350         


Cys Thr Ala Cys Gly Thr Ala Thr Thr Ala Gly Thr Cys Ala Thr Cys 
        355                 360                 365             


Gly Cys Thr Ala Thr Thr Ala Cys Cys Ala Thr Gly Gly Thr Cys Gly 
    370                 375                 380                 


Ala Gly Gly Thr Gly Ala Gly Cys Cys Cys Cys Ala Cys Gly Thr Thr 
385                 390                 395                 400 


Cys Thr Gly Cys Thr Thr Cys Ala Cys Thr Cys Thr Cys Cys Cys Cys 
                405                 410                 415     


Ala Thr Cys Thr Cys Cys Cys Cys Cys Cys Cys Cys Thr Cys Cys Cys 
            420                 425                 430         


Cys Ala Cys Cys Cys Cys Cys Ala Ala Thr Thr Thr Thr Gly Thr Ala 
        435                 440                 445             


Thr Thr Thr Ala Thr Thr Thr Ala Thr Thr Thr Thr Thr Thr Ala Ala 
    450                 455                 460                 


Thr Thr Ala Thr Thr Thr Thr Gly Thr Gly Cys Ala Gly Cys Gly Ala 
465                 470                 475                 480 


Thr Gly Gly Gly Gly Gly Cys Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                485                 490                 495     


Gly Gly Gly Gly Gly Gly Gly Cys Gly Cys Gly Cys Gly Cys Cys Ala 
            500                 505                 510         


Gly Gly Cys Gly Gly Gly Gly Cys Gly Gly Gly Gly Cys Gly Gly Gly 
        515                 520                 525             


Gly Cys Gly Ala Gly Gly Gly Gly Cys Gly Gly Gly Gly Cys Gly Gly 
    530                 535                 540                 


Gly Gly Cys Gly Ala Gly Gly Cys Gly Gly Ala Gly Ala Gly Gly Thr 
545                 550                 555                 560 


Gly Cys Gly Gly Cys Gly Gly Cys Ala Gly Cys Cys Ala Ala Thr Cys 
                565                 570                 575     


Ala Gly Ala Gly Cys Gly Gly Cys Gly Cys Gly Cys Thr Cys Cys Gly 
            580                 585                 590         


Ala Ala Ala Gly Thr Thr Thr Cys Cys Thr Thr Thr Thr Ala Thr Gly 
        595                 600                 605             


Gly Cys Gly Ala Gly Gly Cys Gly Gly Cys Gly Gly Cys Gly Gly Cys 
    610                 615                 620                 


Gly Gly Cys Gly Gly Cys Cys Cys Thr Ala Thr Ala Ala Ala Ala Ala 
625                 630                 635                 640 


Gly Cys Gly Ala Ala Gly Cys Gly Cys Gly Cys Gly Gly Cys Gly Gly 
                645                 650                 655     


Gly Cys Gly Gly Gly Ala Gly Thr Cys Gly Cys Thr Gly Cys Gly Cys 
            660                 665                 670         


Gly Cys Thr Gly Cys Cys Thr Thr Cys Gly Cys Cys Cys Cys Gly Thr 
        675                 680                 685             


Gly Cys Cys Cys Cys Gly Cys Thr Cys Cys Gly Cys Cys Gly Cys Cys 
    690                 695                 700                 


Gly Cys Cys Thr Cys Gly Cys Gly Cys Cys Gly Cys Cys Cys Gly Cys 
705                 710                 715                 720 


Cys Cys Cys Gly Gly Cys Thr Cys Thr Gly Ala Cys Thr Gly Ala Cys 
                725                 730                 735     


Cys Gly Cys Gly Thr Thr Ala Cys Thr Cys Cys Cys Ala Cys Ala Gly 
            740                 745                 750         


Gly Thr Gly Ala Gly Cys Gly Gly Gly Cys Gly Gly Gly Ala Cys Gly 
        755                 760                 765             


Gly Cys Cys Cys Thr Thr Cys Thr Cys Cys Thr Cys Cys Gly Gly Gly 
    770                 775                 780                 


Cys Thr Gly Thr Ala Ala Thr Thr Ala Gly Cys Gly Cys Thr Thr Gly 
785                 790                 795                 800 


Gly Thr Thr Thr Ala Ala Thr Gly Ala Cys Gly Gly Cys Thr Thr Gly 
                805                 810                 815     


Thr Thr Thr Cys Thr Thr Thr Thr Cys Thr Gly Thr Gly Gly Cys Thr 
            820                 825                 830         


Gly Cys Gly Thr Gly Ala Ala Ala Gly Cys Cys Thr Thr Gly Ala Gly 
        835                 840                 845             


Gly Gly Gly Cys Thr Cys Cys Gly Gly Gly Ala Gly Gly Gly Cys Cys 
    850                 855                 860                 


Cys Thr Thr Thr Gly Thr Gly Cys Gly Gly Gly Gly Gly Gly Ala Gly 
865                 870                 875                 880 


Cys Gly Gly Cys Thr Cys Gly Gly Gly Gly Gly Gly Thr Gly Cys Gly 
                885                 890                 895     


Thr Gly Cys Gly Thr Gly Thr Gly Thr Gly Thr Gly Thr Gly Cys Gly 
            900                 905                 910         


Thr Gly Gly Gly Gly Ala Gly Cys Gly Cys Cys Gly Cys Gly Thr Gly 
        915                 920                 925             


Cys Gly Gly Cys Thr Cys Cys Gly Cys Gly Cys Thr Gly Cys Cys Cys 
    930                 935                 940                 


Gly Gly Cys Gly Gly Cys Thr Gly Thr Gly Ala Gly Cys Gly Cys Thr 
945                 950                 955                 960 


Gly Cys Gly Gly Gly Cys Gly Cys Gly Gly Cys Gly Cys Gly Gly Gly 
                965                 970                 975     


Gly Cys Thr Thr Thr Gly Thr Gly Cys Gly Cys Thr Cys Cys Gly Cys 
            980                 985                 990         


Ala Gly Thr Gly Thr Gly Cys Gly  Cys Gly Ala Gly Gly  Gly Gly Ala 
        995                 1000                 1005             


Gly Cys  Gly Cys Gly Gly Cys  Cys Gly Gly Gly Gly  Gly Cys Gly 
    1010                 1015                 1020             


Gly Thr  Gly Cys Cys Cys Cys  Gly Cys Gly Gly Thr  Gly Cys Gly 
    1025                 1030                 1035             


Gly Gly  Gly Gly Gly Gly Gly  Cys Thr Gly Cys Gly  Ala Gly Gly 
    1040                 1045                 1050             


Gly Gly  Ala Ala Cys Ala Ala  Ala Gly Gly Cys Thr  Gly Cys Gly 
    1055                 1060                 1065             


Thr Gly  Cys Gly Gly Gly Gly  Thr Gly Thr Gly Thr  Gly Cys Gly 
    1070                 1075                 1080             


Thr Gly  Gly Gly Gly Gly Gly  Gly Thr Gly Ala Gly  Cys Ala Gly 
    1085                 1090                 1095             


Gly Gly  Gly Gly Thr Gly Thr  Gly Gly Gly Cys Gly  Cys Gly Thr 
    1100                 1105                 1110             


Cys Gly  Gly Thr Cys Gly Gly  Gly Cys Thr Gly Cys  Ala Ala Cys 
    1115                 1120                 1125             


Cys Cys  Cys Cys Cys Cys Thr  Gly Cys Ala Cys Cys  Cys Cys Cys 
    1130                 1135                 1140             


Cys Thr  Cys Cys Cys Cys Gly  Ala Gly Thr Thr Gly  Cys Thr Gly 
    1145                 1150                 1155             


Ala Gly  Cys Ala Cys Gly Gly  Cys Cys Cys Gly Gly  Cys Thr Thr 
    1160                 1165                 1170             


Cys Gly  Gly Gly Thr Gly Cys  Gly Gly Gly Gly Cys  Thr Cys Cys 
    1175                 1180                 1185             


Gly Thr  Ala Cys Gly Gly Gly  Gly Cys Gly Thr Gly  Gly Cys Gly 
    1190                 1195                 1200             


Cys Gly  Gly Gly Gly Cys Thr  Cys Gly Cys Cys Gly  Thr Gly Cys 
    1205                 1210                 1215             


Cys Gly  Gly Gly Cys Gly Gly  Gly Gly Gly Gly Thr  Gly Gly Cys 
    1220                 1225                 1230             


Gly Gly  Cys Ala Gly Gly Thr  Gly Gly Gly Gly Gly  Thr Gly Cys 
    1235                 1240                 1245             


Cys Gly  Gly Gly Cys Gly Gly  Gly Gly Cys Gly Gly  Gly Gly Cys 
    1250                 1255                 1260             


Cys Gly  Cys Cys Thr Cys Gly  Gly Gly Cys Cys Gly  Gly Gly Gly 
    1265                 1270                 1275             


Ala Gly  Gly Gly Cys Thr Cys  Gly Gly Gly Gly Gly  Ala Gly Gly 
    1280                 1285                 1290             


Gly Gly  Cys Gly Cys Gly Gly  Cys Gly Gly Cys Cys  Cys Cys Cys 
    1295                 1300                 1305             


Gly Gly  Ala Gly Cys Gly Cys  Cys Gly Gly Cys Gly  Gly Cys Thr 
    1310                 1315                 1320             


Gly Thr  Cys Gly Ala Gly Gly  Cys Gly Cys Gly Gly  Cys Gly Ala 
    1325                 1330                 1335             


Gly Cys  Cys Gly Cys Ala Gly  Cys Cys Ala Thr Thr  Gly Cys Cys 
    1340                 1345                 1350             


Thr Thr  Thr Thr Ala Thr Gly  Gly Thr Ala Ala Thr  Cys Gly Thr 
    1355                 1360                 1365             


Gly Cys  Gly Ala Gly Ala Gly  Gly Gly Cys Gly Cys  Ala Gly Gly 
    1370                 1375                 1380             


Gly Ala  Cys Thr Thr Cys Cys  Thr Thr Thr Gly Thr  Cys Cys Cys 
    1385                 1390                 1395             


Ala Ala  Ala Thr Cys Thr Gly  Thr Gly Cys Gly Gly  Ala Gly Cys 
    1400                 1405                 1410             


Cys Gly  Ala Ala Ala Thr Cys  Thr Gly Gly Gly Ala  Gly Gly Cys 
    1415                 1420                 1425             


Gly Cys  Cys Gly Cys Cys Gly  Cys Ala Cys Cys Cys  Cys Cys Thr 
    1430                 1435                 1440             


Cys Thr  Ala Gly Cys Gly Gly  Gly Cys Gly Cys Gly  Gly Gly Gly 
    1445                 1450                 1455             


Cys Gly  Ala Ala Gly Cys Gly  Gly Thr Gly Cys Gly  Gly Cys Gly 
    1460                 1465                 1470             


Cys Cys  Gly Gly Cys Ala Gly  Gly Ala Ala Gly Gly  Ala Ala Ala 
    1475                 1480                 1485             


Thr Gly  Gly Gly Cys Gly Gly  Gly Gly Ala Gly Gly  Gly Cys Cys 
    1490                 1495                 1500             


Thr Thr  Cys Gly Thr Gly Cys  Gly Thr Cys Gly Cys  Cys Gly Cys 
    1505                 1510                 1515             


Gly Cys  Cys Gly Cys Cys Gly  Thr Cys Cys Cys Cys  Thr Thr Cys 
    1520                 1525                 1530             


Thr Cys  Cys Cys Thr Cys Thr  Cys Cys Ala Gly Cys  Cys Thr Cys 
    1535                 1540                 1545             


Gly Gly  Gly Gly Cys Thr Gly  Thr Cys Cys Gly Cys  Gly Gly Gly 
    1550                 1555                 1560             


Gly Gly  Gly Ala Cys Gly Gly  Cys Thr Gly Cys Cys  Thr Thr Cys 
    1565                 1570                 1575             


Gly Gly  Gly Gly Gly Gly Gly  Ala Cys Gly Gly Gly  Gly Cys Ala 
    1580                 1585                 1590             


Gly Gly  Gly Cys Gly Gly Gly  Gly Thr Thr Cys Gly  Gly Cys Thr 
    1595                 1600                 1605             


Thr Cys  Thr Gly Gly Cys Gly  Thr Gly Thr Gly Ala  Cys Cys Gly 
    1610                 1615                 1620             


Gly Cys  Gly Gly Cys Thr Cys  Thr Ala Gly Ala Gly  Cys Cys Thr 
    1625                 1630                 1635             


Cys Thr  Gly Cys Thr Ala Ala  Cys Cys Ala Thr Gly  Thr Thr Cys 
    1640                 1645                 1650             


Ala Thr  Gly Cys Cys Thr Thr  Cys Thr Thr Cys Thr  Thr Thr Thr 
    1655                 1660                 1665             


Thr Cys  Cys Thr Ala Cys Ala  Gly Cys Thr Cys Cys  Thr Gly Gly 
    1670                 1675                 1680             


Gly Cys  Ala Ala Cys Gly Thr  Gly Cys Thr Gly Gly  Thr Thr Ala 
    1685                 1690                 1695             


Thr Thr  Gly Thr Gly Cys Thr  Gly Thr Cys Thr Cys  Ala Thr Cys 
    1700                 1705                 1710             


Ala Thr  Thr Thr Thr Gly Gly  Cys Ala Ala Ala Gly  
    1715                 1720                 1725 


<210>  74
<211>  1676
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  74
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacag         1676


<210>  75
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  75
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac t                                                           251


<210>  76
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  76
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  77
<211>  295
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  77
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccgggc tcccaggggc ttcccagtgg tccccaggaa ccctcgacag      240

ggccagggcg tctctctcgt ccagcaaggg cagggacggg ccacaggcca agggc           295


<210>  78
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; polyA

<400>  78
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  79
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; chimeric intron

<400>  79
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  80
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; intron

<400>  80
gtgagtatct cagggatcca gacatgggga tatgggaggt gcctctgatc ccagggctca       60

ctgtgggtct ctctgttcac ag                                                82


<210>  81
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; ITR

<400>  81
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  82
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; ITR

<400>  82
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  83
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; ITR

<400>  83
gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caa                                              143


<210>  84
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; ITR

<400>  84
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                 110


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  85

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  86
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal sequence

<400>  86
atgtatagga tgcaactgct cctcctgatt gctctgagcc tggctcttgt gaccaactct       60


<210>  87
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  87

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala 
            20                  25      


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  88

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala 
            20                  25                  


<210>  89
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  89

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  90
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  90

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala 
        


<210>  91
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  91

Met Arg Leu Leu Ala Phe Leu Ser Leu Leu Ala Leu Val Leu Gln Glu 
1               5                   10                  15      


Thr Gly Thr 
            


<210>  92
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  92

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  93
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  93

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  94
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  94

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  95
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  95

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  96
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  96

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  97
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  97

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  98

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala 
        


<210>  99
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  99

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly 
        


<210>  100
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  100

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala 
            20                  25          


<210>  101
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  101

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys 
            20                  25              


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  102

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser 
            20  


<210>  103
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  103

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly 
        


<210>  104
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  104

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly 
        


<210>  105
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  105

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr 
            


<210>  106
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  106

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser 
            20                  25                  30  


<210>  107
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  107

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala 
            20                  25      


<210>  108
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  108

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser 
        


<210>  109
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  109

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala 
            20              


<210>  110
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  110

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr 
        


<210>  111
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  111

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser 
            20  


<210>  112
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  112

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  113
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  113

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser 
            20                  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  114

Met Ile Ser Arg Met Glu Lys Met Thr Met Met Met Lys Ile Leu Ile 
1               5                   10                  15      


Met Phe Ala Leu Gly Met Asn Tyr Trp Ser Cys Ser Gly 
            20                  25                  


<210>  115
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  115

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


<210>  116
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  116

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  117
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  117

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  118
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  118

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly 
            20          


<210>  119
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  119

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  120
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  120

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly 
            20          


<210>  121
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  121

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly 
        


<210>  122
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  122

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala 
            20                  25          


<210>  123
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  123

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala 
            20          


<210>  124
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  124

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys 
            


<210>  125
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  125

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala 
            20              


<210>  126
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  126

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala 
            20  


<210>  127
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  127

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala 
            20              


<210>  128
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  128

Gly Ser Gly 
1           


<210>  129
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  129

Arg Lys Arg Arg 
1               


<210>  130
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  130

Arg Arg Arg Arg 
1               


<210>  131
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  131

Arg Arg Lys Arg 
1               


<210>  132
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  132

Arg Lys Lys Arg 
1               


<210>  133
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  133

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  134
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  134

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  135
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  135

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  136
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  136

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  137
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  137

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  138
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  138

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  139
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  139

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  140
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  140

Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
1               5                   10                  15      


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25          


<210>  141
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  141

Arg Lys Arg Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  142
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  142

Arg Lys Arg Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25  


<210>  143
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  143

Arg Lys Arg Arg Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu 
1               5                   10                  15      


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25              


<210>  144
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  144

Arg Lys Arg Arg Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe 
1               5                   10                  15      


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25                  30      


<210>  145
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  145
agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg ggatgttgaa       60

gagaatcctg ggcct                                                        75


<210>  146
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  146
agaaagagaa ga                                                           12


<210>  147
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  147
agaaagagaa gaggctctgg a                                                 21


<210>  148
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  148
ggctctgga                                                                9


<210>  149
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  149
gaaggcagag gctccctgct gacatgtggg gatgttgaag agaatcctgg gcct             54


<210>  150
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  150

Cys Pro Pro Cys Pro Ala 
1               5       


<210>  151
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  151

Cys Pro Pro Cys Pro 
1               5   


<210>  152
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  152

Cys Pro Pro Cys Ala 
1               5   


<210>  153
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  153

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  154
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  154

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  155

Glu Pro Lys Ser Cys Asp Lys Thr His Leu 
1               5                   10  


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  156

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  157
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  157

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  158
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  158

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  159
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  159

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  160
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  160

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  161
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  161

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly 
            20          


<210>  162
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  162

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  163
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  163

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  164
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  164

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  165
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  165

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  166

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  167
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  167

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
1               5                   10              


<210>  168
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  168

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  169
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  169

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  170
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  170

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  171
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  171

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  172
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  172

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala 
            20          


<210>  173
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  173

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  174
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  174

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  175
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  175

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly 
            20          


<210>  176
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  176

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  177
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  177

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  178
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  178

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala 
1               5                   10                  15  


<210>  179
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  179

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala 
    


<210>  180
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  180

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala 
    


<210>  181
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  181

Met Leu Leu Ile Leu Leu Ser Val Ala Leu Leu Ala Phe Ser Ser Ala 
1               5                   10                  15      


<210>  182
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  182

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala 
            20  


<210>  183
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody heavy chain


<220>
<221>  misc
<222>  (670)..(681)
<223>  nucleotides 670-681 can be present or absent

<220>
<221>  misc
<222>  (682)..(699)
<223>  nucleotides 682-699 can be present or absent

<220>
<221>  misc
<222>  (700)..(732)
<223>  nucleotides 700-732 can be present or absent

<400>  183
caggtgcagc tgcaggaaag cggcccgggc ctggtgcgcc cgagccagac cctgagcctg       60

acctgcaccg tgagcggcta tagcattacc agcgatcatg cgtggagctg ggtgcgccag      120

ccgccgggcc gcggcctgga atggattggc tatattagct atagcggcat taccacctat      180

aacccgagcc tgaaaagccg cgtgaccatg ctgcgcgata ccagcaaaaa ccagtttagc      240

ctgcgcctga gcagcgtgac cgcggcggat accgcggtgt attattgcgc gcgcagcctg      300

gcgcgcacca ccgcgatgga ttattggggc cagggcagcc tggtgaccgt gagcagcgcg      360

agcaccaaag gcccgagcgt gtttccgctg gcgccgagca gcaaaagcac cagcggcggc      420

accgcggcgc tgggctgcct ggtgaaagat tattttccgg aaccggtgac cgtgagctgg      480

aacagcggcg cgctgaccag cggcgtgcat acctttccgg cggtgctgca gagcagcggc      540

ctgtatagcc tgagcagcgt ggtgaccgtg ccgagcagca gcctgggcac ccagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgcgata agacccacac ctgccccccc tgccccgccc ccgagctgct gggcggcccc      720

agcgtgttcc tg                                                          732


<210>  184
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody light chain

<400>  184
gatattcaga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc       60

attacctgcc gcgcgagcca ggatattagc agctatctga actggtatca gcagaaaccg      120

ggcaaagcgc cgaaactgct gatttattat accagccgcc tgcatagcgg cgtgccgagc      180

cgctttagcg gcagcggcag cggcaccgat tttaccttta ccattagcag cctgcagccg      240

gaagatattg cgacctatta ttgccagcag ggcaacaccc tgccgtatac ctttggccag      300

ggcaccaaag tggaaattaa acgcaccgtg gcggcgccga gcgtgtttat ttttccgccg      360

agcgatgaac agctgaaaag cggcaccgcg agcgtggtgt gcctgctgaa caacttttat      420

ccgcgcgaag cgaaagtgca gtggaaagtg gataacgcgc tgcagagcgg caacagccag      480

gaaagcgtga ccgaacagga tagcaaagat agcacctata gcctgagcag caccctgacc      540

ctgagcaaag cggattatga aaaacataaa gtgtatgcgt gcgaagtgac ccatcagggc      600

ctgagcagcc cggtgaccaa aagctttaac cgcggcgaat gc                         642


<210>  185
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fc domain

<400>  185

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  186
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  186

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  187
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  187

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  188
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  188

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  189
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  189

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  190
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  190

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  191
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  191

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  192
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  192

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  193
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  193

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  194
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  194

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  195
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  195

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  196
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  196

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  197
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  197

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  198
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  198

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  199
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  199

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  200
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  200

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  201
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  201

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  202
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  202

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Arg Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  203
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  203

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Thr Lys Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  204
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  204

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  205
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  205

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Pro Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  206
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  206

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  207
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  207

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  208
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  208

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  209
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  209

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  210
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic constructs; AAV vector

<400>  210

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  211
<211>  1212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  211
gtctaacaaa aaagccaaaa acggccagaa tttagcggac aatttactag tctaacactg       60

aaaattacat attgacccaa atgattacat ttcaaaaggt gcctaaaaaa cttcacaaaa      120

cacactcgcc aaccccgagc gcatagttca aaaccggagc ttcagctact taagaagata      180

ggtacataaa accgaccaaa gaaactgacg cctcacttat ccctcccctc accagaggtc      240

cggcgcctgt cgattcagga gagcctaccc taggcccgaa ccctgcgtcc tgcgacggag      300

aaaagcctac cgcacaccta ccggcaggtg gccccaccct gcattataag ccaacagaac      360

gggtgacgtc acgacacgac gagggcgcgc gctcccaaag gtacgggtgc actgcccaac      420

ggcaccgcca taactgccgc ccccgcaaca gacgacaaac cgagttctcc agtcagtgac      480

aaacttcacg tcagggtccc cagatggtgc cccagcccat ctcacccgaa taagagcttt      540

cccgcattag cgaaggcctc aagaccttgg gttcttgccg cccaccatgc cccccacctt      600

gtttcaacga cctcacagcc cgcctcacaa gcgtcttcca ttcaagactc gggaacagcc      660

gccattttgc tgcgctcccc ccaaccccca gttcagggca accttgctcg cggacccaga      720

ctacagccct tggcggtctc tccacacgct tccgtcccac cgagcggccc ggcggccacg      780

aaagccccgg ccagcccagc agcccgctac tcaccaagtg acgatcacag cgatccacaa      840

acaagaaccg cgacccaaat cccggctgcg acggaactag ctgtgccaca cccggcgcgt      900

ccttatataa tcatcggcgt tcaccgcccc acggagatcc ctccgcagaa tcgccgagaa      960

gggactactt ttcctcgcct gttccgctct ctggaaagaa aaccagtgcc ctagagtcac     1020

ccaagtcccg tcctaaaatg tccttctgct gatactgggg ttctaaggcc gagtcttatg     1080

agcagcgggc cgctgtcctg agcgtccggg cggaaggatc aggacgctcg ctgcgccctt     1140

cgtctgacgt ggcagcgctc gccgtgagga ggggggcgcc cgcgggaggc gccaaaaccc     1200

ggcgcggagg cc                                                         1212


<210>  212
<211>  1724
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  212
ggaggctgag gggtggggaa agggcatggg tgtttcatga ggacagagct tccgtttcat       60

gcaatgaaaa gagtttggag acggatggtg gtgactggac tatacactta cacacggtag      120

cgatggtaca ctttgtatta tgtatatttt accacgatct ttttaaagtg tcaaaggcaa      180

atggccaaat ggttccttgt cctatagctg tagcagccat cggctgttag tgacaaagcc      240

cctgagtcaa gatgacagca gcccccataa ctcctaatcg gctctcccgc gtggagtcat      300

ttaggagtag tcgcattaga gacaagtcca acatctaatc ttccaccctg gccagggccc      360

cagctggcag cgagggtggg agactccggg cagagcagag ggcgctgaca ttggggcccg      420

gcctggcttg ggtccctctg gcctttcccc aggggccctc tttccttggg gctttcttgg      480

gccgccactg ctcccgctcc tctcccccca tcccaccccc tcaccccctc gttcttcata      540

tccttctcta gtgctccctc cactttcatc cacccttctg caagagtgtg ggaccacaaa      600

tgagttttca cctggcctgg ggacacacgt gcccccacag gtgctgagtg actttctagg      660

acagtaatct gctttaggct aaaatgggac ttgatcttct gttagcccta atcatcaatt      720

agcagagccg gtgaaggtgc agaacctacc gcctttccag gcctcctccc acctctgcca      780

cctccactct ccttcctggg atgtgggggc tggcacacgt gtggcccagg gcattggtgg      840

gattgcactg agctgggtca ttagcgtaat cctggacaag ggcagacagg gcgagcggag      900

ggccagctcc ggggctcagg caaggctggg ggcttccccc agacacccca ctcctcctct      960

gctggacccc cacttcatag ggcacttcgt gttctcaaag ggcttccaaa tagcatggtg     1020

gccttggatg cccagggaag cctcagagtt gcttatctcc ctctagacag aaggggaatc     1080

tcggtcaaga gggagaggtc gccctgttca aggccaccca gccagctcat ggcggtaatg     1140

ggacaaggct ggccagccat cccaccctca gaagggaccc ggtggggcag gtgatctcag     1200

aggaggctca cttctgggtc tcacattctt ggatccggtt ccaggcctcg gccctaaata     1260

gtctccctgg gctttcaaga gaaccacatg agaaaggagg attcgggctc tgagcagttt     1320

caccacccac cccccagtct gcaaatcctg acccgtgggt ccacctgccc caaaggcgga     1380

cgcaggacag tagaagggaa cagagaacac ataaacacag agagggccac agcggctccc     1440

acagtcaccg ccaccttcct ggcggggatg ggtggggcgt ctgagtttgg ttcccagcaa     1500

atccctctga gccgcccttg cgggctcgcc tcaggagcag gggagcaaga ggtgggagga     1560

ggaggtctaa gtcccaggcc caattaagag atcaggtagt gtagggtttg ggagctttta     1620

aggtgaagag gcccgggctg atcccacagg ccagtataaa gcgccgtgac cctcaggtga     1680

tgcgccaggg ccggctgccg tcggggacag ggctttccat agcc                      1724


<210>  213
<211>  806
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  213
agatcttccc cacctagcca cctggcaaac tgctccttct ctcaaaggcc caaacatggc       60

ctcccagact gcaaccccca ggcagtcagg ccctgtctcc acaacctcac agccaccctg      120

gacggaatct gcttcttccc acatttgagt cctcctcagc ccctgagctc ctctgggcag      180

ggctgtttct ttccatcttt gtattcccag gggcctgcaa ataaatgttt aatgaacgaa      240

caagagagtg aattccaatt ccatgcaaca aggattgggc tcctgggccc taggctatgt      300

gtctggcacc agaaacggaa gctgcaggtt gcagcccctg ccctcatgga gctcctcctg      360

tcagaggagt gtggggactg gatgactcca gaggtaactt gtgggggaac gaacaggtaa      420

ggggctgtgt gacgagatga gagactggga gaataaacca gaaagtctct agctgtccag      480

aggacatagc acagaggccc atggtcccta tttcaaaccc aggccaccag actgagctgg      540

gaccttggga cagacaagtc atgcagaagt taggggacct tctcctccct tttcctggat      600

ggatcctgag taccttctcc tccctgacct caggcttcct cctagtgtca ccttggcccc      660

tcttagaagc caattaggcc ctcagtttct gcagcgggga ttaatatgat tatgaacacc      720

cccaatctcc cagatgctga ttcagccagg agcttaggag ggggaggtca ctttataagg      780

gtctgggggg gtcagaaccc agagtc                                           806


<210>  214
<211>  1003
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  214
tggccctggc attcccctat actgggacat agaaccttca caggaccaag ggcctctcct       60

cccattgatg actgactagg ccatcctcta gctacatagg tggtggagcc tagagtccct      120

ccttgtgtac tctttggtgg tggttactct gggggtacta ggttagttcg tattgttgtt      180

cctcctaggg gactgcaaac cccttcagct ccttgggtcc tttctctagt tccttctttg      240

gggaccctgt gctcagttca atggatggcc aatttccttc ttaaatgccc ctagcagtaa      300

ctgttaggtc tcaatcccaa gacaaatgtc tgaggtgcct atttaacaga tcaaagcgga      360

cctgtcctca ggttaaccca gtcactccct gtacctcagt ccctacccat cacaattctc      420

cagcccatga gcttcgggct gtacttcccc aacgggttct cccattttgg gtacatggcc      480

tttttttttt acctttttgg ttcctttggc cttttggctt ttggcttcca gggcttctgg      540

atccccccca acccctccca tacacataca catgtgcact cgtgcactca acccagcaca      600

ggataatgtt cattcttgac ctttccacat acatctggct atgttctctc tcttatctac      660

aataaatctc ctccactata cttaggagca gttatgttct tcttctttct ttcttttttt      720

tttttttttc attcagtaac atcatcagaa tcccctagct ctggcctacc tcctcagtaa      780

caatcagctg atccctggcc actaatctgt actcactaat ctgttttcca aactcttggc      840

ccctgagcta attatagcag tgcttcatgc cacccacccc aaccctatcc ttgttctctg      900

actcccacta atctacacat tcagaggatt gtggatataa gaggctggga ggccagctta      960

gcaaccagag ctcgaggctg atgcgagctt catctcttcc ctc                       1003


<210>  215
<211>  523
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  215
tttttttttt acctttttgg ttcctttggc cttttggctt ttggcttcca gggcttctgg       60

atccccccca acccctccca tacacataca catgtgcact cgtgcactca acccagcaca      120

ggataatgtt cattcttgac ctttccacat acatctggct atgttctctc tcttatctac      180

aataaatctc ctccactata cttaggagca gttatgttct tcttctttct ttcttttttt      240

tttttttttc attcagtaac atcatcagaa tcccctagct ctggcctacc tcctcagtaa      300

caatcagctg atccctggcc actaatctgt actcactaat ctgttttcca aactcttggc      360

ccctgagcta attatagcag tgcttcatgc cacccacccc aaccctatcc ttgttctctg      420

actcccacta atctacacat tcagaggatt gtggatataa gaggctggga ggccagctta      480

gcaaccagag ctcgaggctg atgcgagctt catctcttcc ctc                        523


<210>  216
<211>  215
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  216
tgatccctgg ccactaatct gtactcacta atctgttttc caaactcttg gcccctgagc       60

taattatagc agtgcttcat gccacccacc ccaaccctat ccttgttctc tgactcccac      120

taatctacac attcagagga ttgtggatat aagaggctgg gaggccagct tagcaaccag      180

agctcgaggc tgatgcgagc ttcatctctt ccctc                                 215


<210>  217
<211>  198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  217
gggccccaga agcctggtgg ttgtttgtcc ttctcagggg aaaagtgagg cggccccttg       60

gaggaagggg ccgggcagaa tgatctaatc ggattccaag cagctcaggg gattgtcttt      120

ttctagcacc ttcttgccac tcctaagcgt cctccgtgac cccggctggg atttagcctg      180

gtgctgtgtc agccccgg                                                    198


<210>  218
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  218
aaggactcct ttgtggaggt cctggcttag ggagtcaagt gacggcggct cagcactcac       60

gtgggcagtg ccagcctcta agagtgggca ggggcactgg ccacagagtc ccagggagtc      120

ccaccagcct agtcgccaga cc                                               142


<210>  219
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  219
gtcaagtgac ggcggctcag cactcacgtg ggcagtgcca gcctctaaga gtgggcaggg       60

gcactggcca cagagtccca gggagtccca ccagcctagt cgccagacc                  109


<210>  220
<211>  93
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  220
ctcagcactc acgtgggcag tgccagcctc taagagtggg caggggcact ggccacagag       60

tcccagggag tcccaccagc ctagtcgcca gac                                    93


<210>  221
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  221
ttaataaaca tttgggcgat tcttacggcc tctaaagacc aagaaccact gctgcctaga       60

gctctgctct cttcattgaa caatacaaga ggagtgtgta ggtagacacc caccacttcc      120

aacagcttag gagagccctt gagtatggat tgatgtatta aaatttattg aatcacatgc      180

tgagattttc accagctgcc cgtggggatc tgggcattta ttcccatatt gcactggctg      240

gctggaagcc agcagcataa actccagggc tgttctgtca acccccacca gactcacccc      300

gctccaccag ccccggcagg cttctccttc catctctctg aagcaactta ctgatgggcc      360

ctgccagcca atcacagcca gaataacgta tgatgtcacc agcagccaat cagagctcct      420

cgtcagcata tgcagaattc tgtcatttta ctagggtgat gaaattccca agcaacacca      480

tccttttcag ataagggcac tgaggctgag agaggagctg aaacctaccc ggcgtcacca      540

cacacaggtg gcaaggctgg gaccagaaac caggactgtt gactgcagcc cggtattcat      600

tctttccata gcccacaggg ctgtcaaaga ccccagggcc tagtcagagg ctcctccttc      660

ctggagagtt cctggcacag aagttgaagc tcagcacagc cccctaaccc ccaactctct      720

ctgcaaggcc tcaggggtca gaacactggt ggagcagatc ctttagcctc tggattttag      780

ggccatggta gagggggtgt tgccctaaat tccagccctg gtctcagccc aacaccctcc      840

aagaagaaat tagaggggcc atggccaggc tgtgctagcc gttgcttctg agcagattac      900

aagaagggac caagacaagg actcctttgt ggaggtcctg gcttagggag tcaagtgacg      960

gcggctcagc actcacgtgg gcagtgccag cctctaagag tgggcagggg cactggccac     1020

agagtcccag ggagtcccac cagcctagtc gccagacctt ctgtgggatc atcggaccca     1080


<210>  222
<211>  2280
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV-antibody construct

<400>  222
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatt cacgcgtggg      120

cagagcgcac atcgcccaca gtccccgaga agttgggggg aggggtcggc aattgaacgg      180

gtgcctagag aaggtggcgc ggggtaaact gggaaagtga tgtcgtgtac tggctccgcc      240

tttttcccga gggtggggga gaaccgtata taagtgcagt agtcgccgtg aacgttcttt      300

ttcgcaacgg gtttgccgcc agaacacagc aggtgagtat ctcagggatc cagacatggg      360

gatatgggag gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttacc      420

ggtgccacca tgtacagaat gcagctgctg ctgctcattg ccctgtctct ggccctggtc      480

accaattctg aagtgcagct ggtggaaagt ggtggtggac tggtgcagcc tggcagaagc      540

ctgagactgt cttgtgctgc ctctggcttc acctttgatg actatgccat gcactgggtc      600

agacaggccc ctggcaaagg actggaatgg gtgtcagcca tcacctggaa ctctggccac      660

attgactatg ctgactctgt ggaaggcaga ttcaccatca gcagagacaa tgccaagaac      720

agcctgtacc tgcagatgaa ctccctgaga gctgaggaca cagcagtgta ctactgtgcc      780

aaggtgtcct acctgagcac agccagcagc ctggattatt ggggccaggg cacactggtt      840

acagtgtcct ctgccagcac aaagggcccc tctgtttttc cactggctcc cagcagcaag      900

agcaccagtg gtggaacagc tgccctgggc tgtctggtca aggattactt ccctgagcct      960

gtgacagtgt cttggaactc aggggctctg acctctgggg tgcacacatt tccagctgtg     1020

ctgcagtcct ctggcctgta ctctctgtcc tctgtggtca cagtgcctag ctctagcctg     1080

ggcacccaga cctacatctg caatgtgaac cacaagccta gcaacaccaa ggtggacaag     1140

aaggtggaac ccaagagctg tgacaagacc cacagaaaga gaagaggctc tggagaaggc     1200

agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg     1260

caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg     1320

acacagagcc ctagcagcct gtctgcttct gtgggagaca gagtgaccat cacatgcaga     1380

gccagccagg gcatcagaaa ctacctggcc tggtatcagc agaagccagg caaggcccct     1440

aagctgctga tctatgcagc cagcacactg cagagtgggg tgccaagcag attttcaggc     1500

tctggctctg gcacagactt caccctgacc atttctagcc tgcagcctga ggatgtggcc     1560

acctactact gccagagata caacagagcc ccatacacct ttggacaggg cacaaaggtg     1620

gaaatcaaga gaacagttgc agcaccctca gttttcatct tccccccctc agatgaacag     1680

ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca acttctaccc cagagaagcc     1740

aaggtgcagt ggaaggttga caatgccctg cagtcaggca acagccaaga atctgtgact     1800

gaacaggatt ccaaggatag cacctacagc ctgagcagca ccctgacact gagcaaggct     1860

gactatgaga agcacaaagt gtatgcctgt gaagtgaccc accagggact gagcagccca     1920

gtgaccaaga gcttcaacag gggagagtgc tgataaaagc ttgatctttt tccctctgcc     1980

aaaaattatg gggacatcat gaagcccctt gagcatctga cttctggcta ataaaggaaa     2040

tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg ctagcgaagc     2100

aattctagca ggcatgctgg ggagagatcg atctgaggaa cccctagtga tggagttggc     2160

cactccctct ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg     2220

ggcgaccttt ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa     2280


<210>  223
<211>  1972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV-antibody construct

<400>  223
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac agcaggtgag tatctcaggg atccagacat      240

ggggatatgg gaggtgcctc tgatcccagg gctcactgtg ggtctctctg ttcacaggtt      300

accggtgcca ccatgtacag aatgcagctg ctgctgctca ttgccctgtc tctggccctg      360

gtcaccaatt ctgaagtgca gctggtggaa agtggtggtg gactggtgca gcctggcaga      420

agcctgagac tgtcttgtgc tgcctctggc ttcacctttg atgactatgc catgcactgg      480

gtcagacagg cccctggcaa aggactggaa tgggtgtcag ccatcacctg gaactctggc      540

cacattgact atgctgactc tgtggaaggc agattcacca tcagcagaga caatgccaag      600

aacagcctgt acctgcagat gaactccctg agagctgagg acacagcagt gtactactgt      660

gccaaggtgt cctacctgag cacagccagc agcctggatt attggggcca gggcacactg      720

gttacagtgt cctctgccag cacaaagggc ccctctgttt ttccactggc tcccagcagc      780

aagagcacca gtggtggaac agctgccctg ggctgtctgg tcaaggatta cttccctgag      840

cctgtgacag tgtcttggaa ctcaggggct ctgacctctg gggtgcacac atttccagct      900

gtgctgcagt cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagctctagc      960

ctgggcaccc agacctacat ctgcaatgtg aaccacaagc ctagcaacac caaggtggac     1020

aagaaggtgg aacccaagag ctgtgacaag acccacagaa agagaagagg ctctggagaa     1080

ggcagaggct ccctgctgac atgtggggat gttgaagaga atcctgggcc tatgtatagg     1140

atgcaactgc tcctcctgat tgctctgagc ctggctcttg tgaccaactc tgacatccag     1200

atgacacaga gccctagcag cctgtctgct tctgtgggag acagagtgac catcacatgc     1260

agagccagcc agggcatcag aaactacctg gcctggtatc agcagaagcc aggcaaggcc     1320

cctaagctgc tgatctatgc agccagcaca ctgcagagtg gggtgccaag cagattttca     1380

ggctctggct ctggcacaga cttcaccctg accatttcta gcctgcagcc tgaggatgtg     1440

gccacctact actgccagag atacaacaga gccccataca cctttggaca gggcacaaag     1500

gtggaaatca agagaacagt tgcagcaccc tcagttttca tcttcccccc ctcagatgaa     1560

cagctgaagt ctggcactgc ctctgttgtg tgcctgctga acaacttcta ccccagagaa     1620

gccaaggtgc agtggaaggt tgacaatgcc ctgcagtcag gcaacagcca agaatctgtg     1680

actgaacagg attccaagga tagcacctac agcctgagca gcaccctgac actgagcaag     1740

gctgactatg agaagcacaa agtgtatgcc tgtgaagtga cccaccaggg actgagcagc     1800

ccagtgacca agagcttcaa caggggagag tgctgataaa agcttgatct ttttccctct     1860

gccaaaaatt atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg     1920

aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact cg             1972


<210>  224
<211>  2319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV-antibody construct

<400>  224
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggaatt cacgcgtatg      120

gaggcggtac tatgtagatg agaattcagg agcaaactgg gaaaagcaac tgcttccaaa      180

tatttgtgat ttttacagtg tagttttgga aaaactctta gcctaccaat tcttctaagt      240

gttttaaaat gtgggagcca gtacacatga agttatagag tgttttaatg aggcttaaat      300

atttaccgta actatgaaat gctacgcata tcatgctgtt caggctccgt ggccacgcaa      360

ctcatactca ggtgagtatc tcagggatcc agacatgggg atatgggagg tgcctctgat      420

cccagggctc actgtgggtc tctctgttca caggttaccg gtgccaccat gtacagaatg      480

cagctgctgc tgctcattgc cctgtctctg gccctggtca ccaattctga agtgcagctg      540

gtggaaagtg gtggtggact ggtgcagcct ggcagaagcc tgagactgtc ttgtgctgcc      600

tctggcttca cctttgatga ctatgccatg cactgggtca gacaggcccc tggcaaagga      660

ctggaatggg tgtcagccat cacctggaac tctggccaca ttgactatgc tgactctgtg      720

gaaggcagat tcaccatcag cagagacaat gccaagaaca gcctgtacct gcagatgaac      780

tccctgagag ctgaggacac agcagtgtac tactgtgcca aggtgtccta cctgagcaca      840

gccagcagcc tggattattg gggccagggc acactggtta cagtgtcctc tgccagcaca      900

aagggcccct ctgtttttcc actggctccc agcagcaaga gcaccagtgg tggaacagct      960

gccctgggct gtctggtcaa ggattacttc cctgagcctg tgacagtgtc ttggaactca     1020

ggggctctga cctctggggt gcacacattt ccagctgtgc tgcagtcctc tggcctgtac     1080

tctctgtcct ctgtggtcac agtgcctagc tctagcctgg gcacccagac ctacatctgc     1140

aatgtgaacc acaagcctag caacaccaag gtggacaaga aggtggaacc caagagctgt     1200

gacaagaccc acagaaagag aagaggctct ggagaaggca gaggctccct gctgacatgt     1260

ggggatgttg aagagaatcc tgggcctatg tataggatgc aactgctcct cctgattgct     1320

ctgagcctgg ctcttgtgac caactctgac atccagatga cacagagccc tagcagcctg     1380

tctgcttctg tgggagacag agtgaccatc acatgcagag ccagccaggg catcagaaac     1440

tacctggcct ggtatcagca gaagccaggc aaggccccta agctgctgat ctatgcagcc     1500

agcacactgc agagtggggt gccaagcaga ttttcaggct ctggctctgg cacagacttc     1560

accctgacca tttctagcct gcagcctgag gatgtggcca cctactactg ccagagatac     1620

aacagagccc catacacctt tggacagggc acaaaggtgg aaatcaagag aacagttgca     1680

gcaccctcag ttttcatctt ccccccctca gatgaacagc tgaagtctgg cactgcctct     1740

gttgtgtgcc tgctgaacaa cttctacccc agagaagcca aggtgcagtg gaaggttgac     1800

aatgccctgc agtcaggcaa cagccaagaa tctgtgactg aacaggattc caaggatagc     1860

acctacagcc tgagcagcac cctgacactg agcaaggctg actatgagaa gcacaaagtg     1920

tatgcctgtg aagtgaccca ccagggactg agcagcccag tgaccaagag cttcaacagg     1980

ggagagtgct gataaaagct tgatcttttt ccctctgcca aaaattatgg ggacatcatg     2040

aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat tgcaatagtg     2100

tgttggaatt ttttgtgtct ctcactcggc tagcgaagca attctagcag gcatgctggg     2160

gagagatcga tctgaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     2220

ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc     2280

ctcagtgagc gagcgagcgc gcagagaggg agtggccaa                            2319


<210>  225
<211>  2011
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV-antibody construct

<400>  225
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac tcaggtgagt atctcaggga tccagacatg gggatatggg aggtgcctct      300

gatcccaggg ctcactgtgg gtctctctgt tcacaggtta ccggtgccac catgtacaga      360

atgcagctgc tgctgctcat tgccctgtct ctggccctgg tcaccaattc tgaagtgcag      420

ctggtggaaa gtggtggtgg actggtgcag cctggcagaa gcctgagact gtcttgtgct      480

gcctctggct tcacctttga tgactatgcc atgcactggg tcagacaggc ccctggcaaa      540

ggactggaat gggtgtcagc catcacctgg aactctggcc acattgacta tgctgactct      600

gtggaaggca gattcaccat cagcagagac aatgccaaga acagcctgta cctgcagatg      660

aactccctga gagctgagga cacagcagtg tactactgtg ccaaggtgtc ctacctgagc      720

acagccagca gcctggatta ttggggccag ggcacactgg ttacagtgtc ctctgccagc      780

acaaagggcc cctctgtttt tccactggct cccagcagca agagcaccag tggtggaaca      840

gctgccctgg gctgtctggt caaggattac ttccctgagc ctgtgacagt gtcttggaac      900

tcaggggctc tgacctctgg ggtgcacaca tttccagctg tgctgcagtc ctctggcctg      960

tactctctgt cctctgtggt cacagtgcct agctctagcc tgggcaccca gacctacatc     1020

tgcaatgtga accacaagcc tagcaacacc aaggtggaca agaaggtgga acccaagagc     1080

tgtgacaaga cccacagaaa gagaagaggc tctggagaag gcagaggctc cctgctgaca     1140

tgtggggatg ttgaagagaa tcctgggcct atgtatagga tgcaactgct cctcctgatt     1200

gctctgagcc tggctcttgt gaccaactct gacatccaga tgacacagag ccctagcagc     1260

ctgtctgctt ctgtgggaga cagagtgacc atcacatgca gagccagcca gggcatcaga     1320

aactacctgg cctggtatca gcagaagcca ggcaaggccc ctaagctgct gatctatgca     1380

gccagcacac tgcagagtgg ggtgccaagc agattttcag gctctggctc tggcacagac     1440

ttcaccctga ccatttctag cctgcagcct gaggatgtgg ccacctacta ctgccagaga     1500

tacaacagag ccccatacac ctttggacag ggcacaaagg tggaaatcaa gagaacagtt     1560

gcagcaccct cagttttcat cttccccccc tcagatgaac agctgaagtc tggcactgcc     1620

tctgttgtgt gcctgctgaa caacttctac cccagagaag ccaaggtgca gtggaaggtt     1680

gacaatgccc tgcagtcagg caacagccaa gaatctgtga ctgaacagga ttccaaggat     1740

agcacctaca gcctgagcag caccctgaca ctgagcaagg ctgactatga gaagcacaaa     1800

gtgtatgcct gtgaagtgac ccaccaggga ctgagcagcc cagtgaccaa gagcttcaac     1860

aggggagagt gctgataaaa gcttgatctt tttccctctg ccaaaaatta tggggacatc     1920

atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt cattgcaata     1980

gtgtgttgga attttttgtg tctctcactc g                                    2011


<210>  226
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  226

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg 
            20                  25                  30      


<210>  227
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; HIF1alpha site

<400>  227

Arg Cys Gly Thr Gly 
1               5   


<210>  228
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  228
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagt                                                              969


<210>  229
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  229
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt                                      1050


<210>  230
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  230
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagt                                                             1089


<210>  231
<211>  1430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  231
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagcc cttaagctag caggttaatt tttaaaaagc      360

agtcaaaagt ccaagtggcc cttggcagca tttactctct ctgtttgctc tggttaataa      420

tctcaggagc acaaacattc cagatccagg ttaattttta aaaagcagtc aaaagtccaa      480

gtggcccttg gcagcattta ctctctctgt ttgctctggt taataatctc aggagcacaa      540

acattccaga tccggcgcgc cagggctgga agctaccttt gacatcattt cctctgcgaa      600

tgcatgtata atttctacag aacctattag aaaggatcac ccagcctctg cttttgtaca      660

actttccctt aaaaaactgc caattccact gctgtttggc ccaatagtga gaactttttc      720

ctgctgcctc ttggtgcttt tgcctatggc ccctattctg cctgctgaag acactcttgc      780

cagcatggac ttaaacccct ccagctctga caatcctctt tctcttttgt tttacatgaa      840

gggtctggca gccaaagcaa tcactcaaag ttcaaacctt atcatttttt gctttgttcc      900

tcttggcctt ggttttgtac atcagctttg aaaataccat cccagggtta atgctggggt      960

taatttataa ctaagagtgc tctagttttg caatacagga catgctataa aaatggaaag     1020

atgttgcttt ctgagaggat cttgctacca gtggaacagc cactaaggat tctgcagtga     1080

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1140

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1200

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1260

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1320

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1380

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1430


<210>  232
<211>  1318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  232
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagta aaacaggtaa gtccgctgtt tgtgtgctgc ctctgaagtc cacactgaac     1140

aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac     1200

acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggc     1260

ctctactaac catgttcatg ttttcttttt ttttctacag gtcctgggtg acgaacag       1318


<210>  233
<211>  1579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  233
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagt                                                  1579


<210>  234
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  234
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtctaga ggccgtccgc      360

cctcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg tggggagtta      420

tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa aaataactcc      480

cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac ggttcctcac      540

ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg gccgggcggt      600

gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag ctacccggag      660

gagcgggagg cgccaagcgt gagtatcgat cttgctacca gtggaacagc cactaaggat      720

tctgcagtga gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg      780

ccaccccctc caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct      840

ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg      900

ggcgactcag atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg      960

accttggtta atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat     1020

acggacgagg acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt     1080


<210>  235
<211>  568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  235
gaatggtgga cacccaaata tggcgacggt tcctcacccg tcgccatatt tgggtgtccg       60

ccctcggccg gggccgcatt cctgggggcc gggcggtgct cccgcccgcc tcgataaaag      120

gctccggggc cggcggcggc ccacgagcta cccggaggag cgggaggcgc caagcgatct      180

tgctaccagt ggaacagcca ctaaggattc tgcagtgaga gcagagggcc agctaagtgg      240

tactctccca gagactgtct gactcacgcc accccctcca ccttggacac aggacgctgt      300

ggtttctgag ccaggtacag tgactccttt cggtaagtgc agtggaagct gtacactgcc      360

caggcaaagc gtccgggcag cgtaggcggg cgactcagat cccagccagt ggacttagcc      420

cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc agcctccccc      480

gttgcccctc tggatccact gcttaaatac ggacgaggac agggccctgt ctcctcagct      540

tcaggcacca ccactgacct gggacagt                                         568


<210>  236
<211>  895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  236
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagaa tggtggacac ccaaatatgg cgacggttcc      360

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg      420

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc      480

ggaggagcgg gaggcgccaa gcgatcttgc taccagtgga acagccacta aggattctgc      540

agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac tcacgccacc      600

ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacagtga ctcctttcgg      660

taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt aggcgggcga      720

ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg gggtgacctt      780

ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct taaatacgga      840

cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg acagt           895


<210>  237
<211>  1291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  237
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccctg catgcgaaga      480

tcttcgaaca aggctgtggg ggactgaggg caggctgtaa caggcttggg ggccagggct      540

tatacgtgcc tgggactccc aaagtattac tgttccatgt tcccggcgaa gggccagctg      600

tcccccgcca gctagactca gcacttagtt taggaaccag tgagcaagtc agcccttggg      660

gcagcccata caaggccatg gggctgggca agctgcacgc ctgggtccgg ggtgggcacg      720

gtgcccgggc aacgagctga aagctcatct gctctcaggg gcccctccct ggggacagcc      780

cctcctggct agtcacaccc tgtaggctcc tctatataac ccaggggcac aggggctgcc      840

ctcattctac caccacctcc acagcacaga cagacactca ggagccagcc agcgtcgaga      900

tcttgctacc agtggaacag ccactaagga ttctgcagtg agagcagagg gccagctaag      960

tggtactctc ccagagactg tctgactcac gccaccccct ccaccttgga cacaggacgc     1020

tgtggtttct gagccaggta cagtgactcc tttcggtaag tgcagtggaa gctgtacact     1080

gcccaggcaa agcgtccggg cagcgtaggc gggcgactca gatcccagcc agtggactta     1140

gcccctgttt gctcctccga taactggggt gaccttggtt aatattcacc agcagcctcc     1200

cccgttgccc ctctggatcc actgcttaaa tacggacgag gacagggccc tgtctcctca     1260

gcttcaggca ccaccactga cctgggacag t                                    1291


<210>  238
<211>  1147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  238
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccctgcatg cgaagatctt cgaacaaggc tgtgggggac      360

tgagggcagg ctgtaacagg cttgggggcc agggcttata cgtgcctggg actcccaaag      420

tattactgtt ccatgttccc ggcgaagggc cagctgtccc ccgccagcta gactcagcac      480

ttagtttagg aaccagtgag caagtcagcc cttggggcag cccatacaag gccatggggc      540

tgggcaagct gcacgcctgg gtccggggtg ggcacggtgc ccgggcaacg agctgaaagc      600

tcatctgctc tcaggggccc ctccctgggg acagcccctc ctggctagtc acaccctgta      660

ggctcctcta tataacccag gggcacaggg gctgccctca ttctaccacc acctccacag      720

cacagacaga cactcaggag ccagccagcg tcgagatctt gctaccagtg gaacagccac      780

taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg      840

actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacagt      900

gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc      960

gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac     1020

tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg     1080

cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg     1140

ggacagt                                                               1147


<210>  239
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  239
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gcccttcaga ttaaaaataa ctgaggtaag ggcctgggta      360

ggggaggtgg tgtgagacgc tcctgtctct cctctatctg cccatcggcc ctttggggag      420

gaggaatgtg cccaaggact aaaaaaaggc catggagcca gaggggcgag ggcaacagac      480

ctttcatggg caaaccttgg ggccctgctg aagctttggc ccactacggg tttaggctgc      540

ccatgtaagg aggcaaggcc tggggacacc cgagatgcct ggttataatt aacccagaca      600

tgtggctgcc cccccccccc ccaacacctg ctgcctctaa aaataaccct gtccctggtg      660

gatcccctgc atgcgaagat cttcgaacaa ggctgtgggg gactgagggc aggctgtaac      720

aggcttgggg gccagggctt atacgtgcct gggactccca aagtattact gttccatgtt      780

cccggcgaag ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt      840

gagcaagtca gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc      900

tgggtccggg gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg      960

cccctccctg gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc     1020

caggggcaca ggggctgccc tcattctacc accacctcca cagcacagac agacactcag     1080

gagccagcca gcgtcgagat cttgctacca gtggaacagc cactaaggat tctgcagtga     1140

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1200

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1260

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1320

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1380

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1440

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1490


<210>  240
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  240
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agt                                                                    723


<210>  241
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  241
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc                            100


<210>  242
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  242
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc aggttaattt ttaaaaagca      120

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat      180

ctcaggagca caaacattcc                                                  200


<210>  243
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  243
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210>  244
<211>  554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  244
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctg                                                        554


<210>  245
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  245
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  246
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  246
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  247
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  247
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatc                                             144


<210>  248
<211>  288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  248
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatc                   288


<210>  249
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  249
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tc                                                          432


<210>  250
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory element

<400>  250
cccttcagat taaaaataac tgaggtaagg gcctgggtag gggaggtggt gtgagacgct       60

cctgtctctc ctctatctgc ccatcggccc tttggggagg aggaatgtgc ccaaggacta      120

aaaaaaggcc atggagccag aggggcgagg gcaacagacc tttcatgggc aaaccttggg      180

gccctgctga agctttggc                                                   199


<210>  251
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; cleavage site


<220>
<221>  misc
<222>  (2)..(2)
<223>  Xaa can be any amino acid

<400>  251

Arg Xaa Lys Arg 
1               


<210>  252
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; cleavage site


<220>
<221>  misc
<222>  (2)..(2)
<223>  Xaa can be any amino acid

<400>  252

Arg Xaa Arg Arg 
1               


<210>  253
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  253

Asp Thr Ala Val Tyr Tyr 
1               5       


<210>  254
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  254

Glu Asp Ile Ala Thr Tyr Tyr 
1               5           


<210>  255
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  255

Glu Asp Glu Ala Asp Tyr Tyr 
1               5           


<210>  256
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  256

Glu Asp Thr Ala Val Tyr Tyr 
1               5           


<210>  257
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge

<400>  257

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  258

Glu Asp Phe Ala Thr Tyr Tyr 
1               5           


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  259

Glu Asp Phe Ala Val Tyr Tyr 
1               5           


<210>  260
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  260

Asp Asp Phe Ala Thr Tyr Tyr 
1               5           


<210>  261
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  261

Glu Asp Thr Ala Met Tyr Tyr 
1               5           


<210>  262
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  262

Glu Asp Ala Ala Thr Tyr Tyr 
1               5           


<210>  263
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  263

Phe Thr Phe Asp Asp Tyr Ala 
1               5           


<210>  264
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  264

Glu Asp Thr Ala Leu Tyr Tyr 
1               5           


<210>  265
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  265

Glu Asp Phe Ala Ser Tyr Tyr 
1               5           


<210>  266
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  266

Tyr Thr Cys Asn Val Asp 
1               5       


<210>  267
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  267

Glu Leu Leu Ile Tyr Tyr 
1               5       


<210>  268
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  268

Tyr Tyr Tyr Gly Met Asp 
1               5       


<210>  269
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  269

Glu Asp Thr Gly Val Tyr Tyr 
1               5           


<210>  270
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  270

Glu Asp Ile Ala Asp Tyr Tyr 
1               5           


<210>  271
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  271

Glu Asp Val Ala Thr Tyr Tyr 
1               5           


<210>  272
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; intron

<400>  272

Gly Thr Ala Ala Gly Thr Thr Thr Ala Gly Thr Cys Thr Thr Thr Thr 
1               5                   10                  15      


Thr Gly Thr Cys Thr Thr Thr Thr Ala Thr Thr Thr Cys Ala Gly Gly 
            20                  25                  30          


Thr Cys Cys Cys Gly Gly Ala Thr Cys Cys Gly Gly Thr Gly Gly Thr 
        35                  40                  45              


Gly Gly Thr Gly Cys Ala Ala Ala Thr Cys Ala Ala Ala Gly Ala Ala 
    50                  55                  60                  


Cys Thr Gly Cys Thr Cys Cys Thr Cys Ala Gly Thr Gly Gly Ala Thr 
65                  70                  75                  80  


Gly Thr Thr Gly Cys Cys Thr Thr Thr Ala Cys Thr Thr Cys Thr Ala 
                85                  90                  95      


Gly 
    


<210>  273
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  273
gacgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgg                                                                    663


<210>  274
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  274
gacgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cg                         762


<210>  275
<211>  935
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  275
gtcgacaaat tctgtcattt tactagggtg atgaaattcc caagcaacac catccttttc       60

agataagggc actgaggctg agagaggagc tgaaacctac ccggggtcac cacacacagg      120

tggcaaggct gggaccagaa accaggactg ttgactgcag cccggtattc attctttcca      180

tagcccacag ggctgtcaaa gaccccaggg cctagtcaga ggctcctcct tcctggagag      240

ttcctggcac agaagttgaa gctcagcaca gccccctaac ccccaactct ctctgcaagg      300

cctcaggggt cagaacactg gtggagcaga tcctttagcc tctggatttt agggccatgg      360

tagagggggt gttgccctaa attccagccc tggtctcagc ccaacaccct ccaagaagaa      420

attagagggg ccatggccag gctgtgctag ccgttgcttc tgagcagatt acaagaaggg      480

actaagacaa ggactccttt gtggaggtcc tggcttaggg agtcaagtga cggcggctca      540

gcactcacgt gggcagtgcc agcctctaag agtgggcagg ggcactggcc acagagtccc      600

agggagtccc accagcctag tcgccagatc tagagggccc cagaagcctg gtggttgttt      660

gtccttctca ggggaaaagt gaggcggccc cttggaggaa ggggccgggc agaagatcta      720

atcggattcc aagcagctca ggggattgtc tttttctagc accttcttgc cactcctaag      780

cgtcctccgt gaccccggct gggatttagc ctggtgctgt gtcagccccg ggctcccagg      840

ggcttcccag tggtccccag gaaccctcga cagggccagg gcgtctctct cgtccagcaa      900

gggcagggac gggccacagg ccaagggcct taagc                                 935


<210>  276
<211>  3133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody construct

<400>  276
gacgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cggacgcgtc aggtgagtat ctcagggatc cagacatggg gatatgggag gtgcctctga      720

tcccagggct cactgtgggt ctctctgttc acaggttgac cgagtgaatt cgccaccatg      780

tacagaatgc agctgctgct gctcattgcc ctgtctctgg ccctggtcac caattctgaa      840

gtgcagctgg tggaaagtgg tggtggactg gtgcagcctg gcagaagcct gagactgtct      900

tgtgctgcct ctggcttcac ctttgatgac tatgccatgc actgggtcag acaggcccct      960

ggcaaaggac tggaatgggt gtcagccatc acctggaact ctggccacat tgactatgct     1020

gactctgtgg aaggcagatt caccatcagc agagacaatg ccaagaacag cctgtacctg     1080

cagatgaact ccctgagagc tgaggacaca gcagtgtact actgtgccaa ggtgtcctac     1140

ctgagcacag ccagcagcct ggattattgg ggccagggca cactggttac agtgtcctct     1200

gccagcacaa agggcccctc tgtttttcca ctggctccca gcagcaagag caccagtggt     1260

ggaacagctg ccctgggctg tctggtcaag gattacttcc ctgagcctgt gacagtgtct     1320

tggaactcag gggctctgac ctctggggtg cacacatttc cagctgtgct gcagtcctct     1380

ggcctgtact ctctgtcctc tgtggtcaca gtgcctagct ctagcctggg cacccagacc     1440

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagaa ggtggaaccc     1500

aagagctgtg acaagaccca cacctgtcct ccatgtcctg ctccagaact gcttggaggc     1560

ccttctgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct     1620

gaagtgacct gtgtggtggt tgatgtgtcc catgaggacc cagaagtgaa gttcaattgg     1680

tatgtggatg gggttgaagt gcacaatgct aagaccaagc ctagagagga acagtacaac     1740

agcacctaca gagtggtgtc tgtgctgaca gtgctgcatc aggactggct gaatggcaaa     1800

gagtacaagt gcaaagtgtc caacaaggcc ctgcctgctc ctattgagaa aaccatctcc     1860

aaggccaagg gccagccaag agaaccccag gtttacacac tgccacctag cagagatgag     1920

ctgaccaaga accaggtgtc cctgacctgc ctggttaagg gcttctaccc ctctgacatt     1980

gctgtggaat gggagagcaa tggccagcct gagaacaact acaagacaac ccctcctgtg     2040

ctggactctg atggctcatt cttcctgtac agcaagctga ctgtggacaa gtccagatgg     2100

cagcagggga atgtgttcag ctgctctgtg atgcatgagg ccctgcacaa ccactacacc     2160

cagaaaagtc tgagtctgag ccctggcaag agaaagagaa gaggctctgg agaaggcaga     2220

ggctccctgc tgacatgtgg ggatgttgaa gagaatcctg ggcctatgta taggatgcaa     2280

ctgctcctcc tgattgctct gagcctggct cttgtgacca actctgacat ccagatgaca     2340

cagagcccta gcagcctgtc tgcttctgtg ggagacagag tgaccatcac atgcagagcc     2400

agccagggaa tcagaaacta cctggcctgg tatcagcaaa agcctggcaa ggcccctaag     2460

ctgctgatct atgcagccag cacactgcag tcaggggtgc caagcagatt ttcaggctct     2520

ggctctggca cagacttcac cctgaccatt tctagcctgc agcctgagga tgtggccacc     2580

tactactgcc agagatacaa cagagcccca tacacctttg gacagggcac aaaggtggaa     2640

atcaagagaa cagtggctgc cccatctgtg ttcatcttcc caccatctga tgaacagctg     2700

aagtctggca ctgcctctgt tgtgtgcctg ctgaacaact tctaccctag agaagccaag     2760

gtgcagtgga aggttgacaa tgccctgcag tctggcaata gccaagaatc tgtgacagag     2820

caggactcca aggattccac ctacagcctg agcagcaccc tgacactgag caaggctgac     2880

tatgagaagc acaaagtgta tgcctgtgaa gtgacacacc agggactgag cagcccagtg     2940

accaagagct tcaacagggg agagtgctga taactcgagg acggggtgaa ctacgcctga     3000

ggatccgatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat     3060

ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg     3120

tgtctctcac tcg                                                        3133


<210>  277
<211>  3554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody construct

<400>  277
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacgaca ttgattattg actagttatt aatagtaatc      240

aattacgggg tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt      300

aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta      360

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      420

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      480

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      540

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc      600

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt      660

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      720

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa      780

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      840

taaaaagcga agcgcgcggc gggcggacgc gtcaggtgag tatctcaggg atccagacat      900

ggggatatgg gaggtgcctc tgatcccagg gctcactgtg ggtctctctg ttcacaggtt      960

gaccgagtga attcgccacc atgtacagaa tgcagctgct gctgctcatt gccctgtctc     1020

tggccctggt caccaattct gaagtgcagc tggtggaaag tggtggtgga ctggtgcagc     1080

ctggcagaag cctgagactg tcttgtgctg cctctggctt cacctttgat gactatgcca     1140

tgcactgggt cagacaggcc cctggcaaag gactggaatg ggtgtcagcc atcacctgga     1200

actctggcca cattgactat gctgactctg tggaaggcag attcaccatc agcagagaca     1260

atgccaagaa cagcctgtac ctgcagatga actccctgag agctgaggac acagcagtgt     1320

actactgtgc caaggtgtcc tacctgagca cagccagcag cctggattat tggggccagg     1380

gcacactggt tacagtgtcc tctgccagca caaagggccc ctctgttttt ccactggctc     1440

ccagcagcaa gagcaccagt ggtggaacag ctgccctggg ctgtctggtc aaggattact     1500

tccctgagcc tgtgacagtg tcttggaact caggggctct gacctctggg gtgcacacat     1560

ttccagctgt gctgcagtcc tctggcctgt actctctgtc ctctgtggtc acagtgccta     1620

gctctagcct gggcacccag acctacatct gcaatgtgaa ccacaagcct agcaacacca     1680

aggtggacaa gaaggtggaa cccaagagct gtgacaagac ccacacctgt cctccatgtc     1740

ctgctccaga actgcttgga ggcccttctg tgttcctgtt tcctccaaag cctaaggaca     1800

ccctgatgat cagcagaacc cctgaagtga cctgtgtggt ggttgatgtg tcccatgagg     1860

acccagaagt gaagttcaat tggtatgtgg atggggttga agtgcacaat gctaagacca     1920

agcctagaga ggaacagtac aacagcacct acagagtggt gtctgtgctg acagtgctgc     1980

atcaggactg gctgaatggc aaagagtaca agtgcaaagt gtccaacaag gccctgcctg     2040

ctcctattga gaaaaccatc tccaaggcca agggccagcc aagagaaccc caggtttaca     2100

cactgccacc tagcagagat gagctgacca agaaccaggt gtccctgacc tgcctggtta     2160

agggcttcta cccctctgac attgctgtgg aatgggagag caatggccag cctgagaaca     2220

actacaagac aacccctcct gtgctggact ctgatggctc attcttcctg tacagcaagc     2280

tgactgtgga caagtccaga tggcagcagg ggaatgtgtt cagctgctct gtgatgcatg     2340

aggccctgca caaccactac acccagaaaa gtctgagtct gagccctggc aagagaaaga     2400

gaagaggctc tggagaaggc agaggctccc tgctgacatg tggggatgtt gaagagaatc     2460

ctgggcctat gtataggatg caactgctcc tcctgattgc tctgagcctg gctcttgtga     2520

ccaactctga catccagatg acacagagcc ctagcagcct gtctgcttct gtgggagaca     2580

gagtgaccat cacatgcaga gccagccagg gaatcagaaa ctacctggcc tggtatcagc     2640

aaaagcctgg caaggcccct aagctgctga tctatgcagc cagcacactg cagtcagggg     2700

tgccaagcag attttcaggc tctggctctg gcacagactt caccctgacc atttctagcc     2760

tgcagcctga ggatgtggcc acctactact gccagagata caacagagcc ccatacacct     2820

ttggacaggg cacaaaggtg gaaatcaaga gaacagtggc tgccccatct gtgttcatct     2880

tcccaccatc tgatgaacag ctgaagtctg gcactgcctc tgttgtgtgc ctgctgaaca     2940

acttctaccc tagagaagcc aaggtgcagt ggaaggttga caatgccctg cagtctggca     3000

atagccaaga atctgtgaca gagcaggact ccaaggattc cacctacagc ctgagcagca     3060

ccctgacact gagcaaggct gactatgaga agcacaaagt gtatgcctgt gaagtgacac     3120

accagggact gagcagccca gtgaccaaga gcttcaacag gggagagtgc tgataactcg     3180

aggacggggt gaactacgcc tgaggatccg atctttttcc ctctgccaaa aattatgggg     3240

acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt attttcattg     3300

caatagtgtg ttggaatttt ttgtgtctct cactcggaag caattcgttg atctgaattt     3360

cgaccaccca taatacccat taccctggta gataagtagc atggcgggtt aatcattaac     3420

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     3480

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     3540

gagcgagcgc gcag                                                       3554


