                         SEQUENCE LISTING

<110>  Albert Einstein College of Medicine
 
<120>  REPORTER MYCOBACTERIOPHAGE, ASSAYS AND METHODS COMPRISING THE 
       REPORTER MYCOBACTERIOPHAGE

<130>  EIC0038PCT (C-00001409)

<150>  US 63/107,744
<151>  2020-10-30

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  257
<212>  DNA
<213>  Artificial sequence

<220>
<223>  L5 promoter

<400>  1
ctagaggaaa cagctatgac catgattacg ccaagcttgc atgcctgcag ctagggcacc       60

aatttgcgat tagggcttga cagccacccg gccagtagtg cattcttgtg tcaccgcagc      120

agcaaggcgg taggcggatc cgagaggatc gtgccggtgc cggtgaaaat ccggcggcaa      180

gattctccgg tttgacagcc acccggttat cgggtaagct gcaagcatca ccaacttgga      240

cgggaaaggg agatcgc                                                     257


<210>  2
<211>  1367
<212>  DNA
<213>  Artificial sequence

<220>
<223>  OriM

<400>  2
gtggggtggc ccctcagcga aatatctgac ttggagctcg tgtcggacca tacaccggtg       60

attaatcgtg gtttattatc aagcgtgagc cacgtcgccg acgaatttga gcagctctgg      120

ctgccgtact ggtccctggc aagcgacgat ctgctcgagg ggatctaccg ccaaagccgc      180

gcgtcggccc taggccgccg gtacatcgag gcgaacccaa cagcgctggc aaacctgctg      240

gtcgtggacg tagaccatcc agacgcagcg ctccgagcgc tcagcgcccg ggggtcccat      300

ccgctgccca acgcgatcgt gggcaatcgc gccaacggcc acgcacacgc agtgtgggca      360

ctcaacgccc ctgttccacg caccgaatac gcgcggcgta agccgctcgc atacatggcg      420

gcgtgcgccg aaggccttcg gcgcgccgtc gatggcgacc gcagttactc aggcctcatg      480

accaaaaacc ccggccacat cgcctgggaa acggaatggc tccactcaga tctctacaca      540

ctcagccaca tcgaggccga gctcggcgcg aacatgccac cgccgcgctg gcgtcagcag      600

accacgtaca aagcggctcc gacgccgcta gggcggaatt gcgcactgtt cgattccgtc      660

aggttgtggg cctatcttcc cgccctcatg cggatctacc tgccgacccg gaacgtggac      720

ggactcggcc gcgcgatcta tgccgagtgc cacgcgcgaa acgccgaatt tccgtgcaac      780

gacgtgtgtc ccggaccgct accggacagc gaggtccgcg ccatcgccaa cagcatttgg      840

cgttggatca caaccaagtc gcgcatttgg gcggacggga tcgtggtcta cgaggccaca      900

ctcagtgcgc gccatgcggc catctcgcgg aagggcgcag cagcgcgcac ggcggcgagc      960

acagttgcgc ggcgcgcaaa gtccgcgtca gccatggagg cattgctatg agcgacggct     1020

acagcgacgg ctacagcgac ggctacaact ggcagccgac tgtccgcaaa aagcggcgcg     1080

tgaccgccgc cgaaggcgct cgaatcaccg gactatccga acgccacgtc gtccggctcg     1140

tggcgcagga acgcagcgag tggttcgccg agcaggctgc acgccgcgaa cgcatccgcg     1200

cctatcacga cgacgagggc cactcttggc cgcaaacggc caaacatttc gggctgcatc     1260

tggacaccgt taagcgactc ggctatcggg cgaggaaaga gcgtgcggca gaacaggaag     1320

cggctcaaaa ggcccacaac gaagccgaca atccaccgct gttctaa                   1367


<210>  3
<211>  1185
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mNeon_green-nLuc

<400>  3
atggtgtcca agggcgaaga ggacaacatg gccagcctgc ctgccaccca cgagctgcac       60

atcttcggca gcatcaacgg cgtggacttc gacatggtgg gacagggcac cggcaacccc      120

aacgacggct acgaggaact gaacctgaag tccacaaagg gcgacctgca gttcagcccc      180

tggattctgg tgccccacat cggctacggc ttccaccagt acctgcccta ccccgacggc      240

atgagccctt tccaggccgc tatggtggat ggcagcggct accaggtgca ccggaccatg      300

cagtttgagg acggcgccag cctgaccgtg aactaccggt acacatacga gggcagccac      360

atcaagggcg aggcccaagt gaagggcaca ggctttccag ccgacggccc cgtgatgacc      420

aatagcctga cagccgccga ctggtgcaga agcaagaaaa cctaccccaa tgacaagacc      480

atcatcagca ccttcaagtg gtcctacacc accggcaatg gcaagcggta cagaagcacc      540

gcccggacca cctacacctt cgccaaacct atggccgcca actacctgaa gaaccagcct      600

atgtacgtgt tccgcaagac cgagctgaag cactccaaga cagaactgaa cttcaaagag      660

tggcagaaag ccttcaccgg gtttgaagat ttcgttgggg actggcgaca gacagccggc      720

tacaacctgg accaagtcct tgaacaggga ggtgtgtcca gtttgtttca gaatctcggg      780

gtgtccgtaa ctccgatcca aaggattgtc ctgagcggtg aaaatgggct gaagatcgac      840

atccatgtca tcatcccgta tgaaggtctg agcggcgacc aaatgggcca gatcgaaaaa      900

atttttaagg tggtgtaccc tgtggatgat catcacttta aggtgatcct gcactatggc      960

acactggtaa tcgacggggt tacgccgaac atgatcgact atttcggacg gccgtatgaa     1020

ggcatcgccg tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac     1080

aaaattatcg acgagcgcct gatcaacccc gacggctccc tgctgttccg agtaaccatc     1140

aacggagtga ccggctggcg gctgtgcgaa cgcattctgg cgtaa                     1185


<210>  4
<211>  394
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mNeon_green-nLuc

<400>  4

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ser Leu Pro Ala Thr 
1               5                   10                  15      


His Glu Leu His Ile Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met 
            20                  25                  30          


Val Gly Gln Gly Thr Gly Asn Pro Asn Asp Gly Tyr Glu Glu Leu Asn 
        35                  40                  45              


Leu Lys Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val 
    50                  55                  60                  


Pro His Ile Gly Tyr Gly Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly 
65                  70                  75                  80  


Met Ser Pro Phe Gln Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val 
                85                  90                  95      


His Arg Thr Met Gln Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr 
            100                 105                 110         


Arg Tyr Thr Tyr Glu Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys 
        115                 120                 125             


Gly Thr Gly Phe Pro Ala Asp Gly Pro Val Met Thr Asn Ser Leu Thr 
    130                 135                 140                 


Ala Ala Asp Trp Cys Arg Ser Lys Lys Thr Tyr Pro Asn Asp Lys Thr 
145                 150                 155                 160 


Ile Ile Ser Thr Phe Lys Trp Ser Tyr Thr Thr Gly Asn Gly Lys Arg 
                165                 170                 175     


Tyr Arg Ser Thr Ala Arg Thr Thr Tyr Thr Phe Ala Lys Pro Met Ala 
            180                 185                 190         


Ala Asn Tyr Leu Lys Asn Gln Pro Met Tyr Val Phe Arg Lys Thr Glu 
        195                 200                 205             


Leu Lys His Ser Lys Thr Glu Leu Asn Phe Lys Glu Trp Gln Lys Ala 
    210                 215                 220                 


Phe Thr Gly Phe Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
                245                 250                 255     


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
            260                 265                 270         


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
        275                 280                 285             


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
    290                 295                 300                 


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
305                 310                 315                 320 


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
                325                 330                 335     


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
            340                 345                 350         


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
        355                 360                 365             


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
    370                 375                 380                 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
385                 390                 


<210>  5
<211>  1200
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mTurquoise-nLuc

<400>  5
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgtcctg gggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactactt tagcgacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggttg catacactcg aagatttcgt tggggactgg      720

cgacagacag ccggctacaa cctggaccaa gtccttgaac agggaggtgt gtccagtttg      780

tttcagaatc tcggggtgtc cgtaactccg atccaaagga ttgtcctgag cggtgaaaat      840

gggctgaaga tcgacatcca tgtcatcatc ccgtatgaag gtctgagcgg cgaccaaatg      900

ggccagatcg aaaaaatttt taaggtggtg taccctgtgg atgatcatca ctttaaggtg      960

atcctgcact atggcacact ggtaatcgac ggggttacgc cgaacatgat cgactatttc     1020

ggacggccgt atgaaggcat cgccgtgttc gacggcaaaa agatcactgt aacagggacc     1080

ctgtggaacg gcaacaaaat tatcgacgag cgcctgatca accccgacgg ctccctgctg     1140

ttccgagtaa ccatcaacgg agtgaccggc tggcggctgt gcgaacgcat tctggcgtaa     1200


<210>  6
<211>  399
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mTurquoise-nLuc

<400>  6

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Phe Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Leu His Thr Leu Glu Asp Phe Val Gly Asp Trp 
225                 230                 235                 240 


Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly 
                245                 250                 255     


Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln 
            260                 265                 270         


Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val 
        275                 280                 285             


Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu 
    290                 295                 300                 


Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
305                 310                 315                 320 


Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
                325                 330                 335     


Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
            340                 345                 350         


Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
        355                 360                 365             


Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
    370                 375                 380                 


Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
385                 390                 395                 


<210>  7
<211>  1875
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mNeon_green-nLuc-mNeon_green

<400>  7
atggtgtcca agggcgaaga ggacaacatg gccagcctgc ctgccaccca cgagctgcac       60

atcttcggca gcatcaacgg cgtggacttc gacatggtgg gacagggcac cggcaacccc      120

aacgacggct acgaggaact gaacctgaag tccacaaagg gcgacctgca gttcagcccc      180

tggattctgg tgccccacat cggctacggc ttccaccagt acctgcccta ccccgacggc      240

atgagccctt tccaggccgc tatggtggat ggcagcggct accaggtgca ccggaccatg      300

cagtttgagg acggcgccag cctgaccgtg aactaccggt acacatacga gggcagccac      360

atcaagggcg aggcccaagt gaagggcaca ggctttccag ccgacggccc cgtgatgacc      420

aatagcctga cagccgccga ctggtgcaga agcaagaaaa cctaccccaa tgacaagacc      480

atcatcagca ccttcaagtg gtcctacacc accggcaatg gcaagcggta cagaagcacc      540

gcccggacca cctacacctt cgccaaacct atggccgcca actacctgaa gaaccagcct      600

atgtacgtgt tccgcaagac cgagctgaag cactccaaga cagaactgaa cttcaaagag      660

tggcagaaag ccttcaccgg gtttgaagat ttcgttgggg actggcgaca gacagccggc      720

tacaacctgg accaagtcct tgaacaggga ggtgtgtcca gtttgtttca gaatctcggg      780

gtgtccgtaa ctccgatcca aaggattgtc ctgagcggtg aaaatgggct gaagatcgac      840

atccatgtca tcatcccgta tgaaggtctg agcggcgacc aaatgggcca gatcgaaaaa      900

atttttaagg tggtgtaccc tgtggatgat catcacttta aggtgatcct gcactatggc      960

acactggtaa tcgacggggt tacgccgaac atgatcgact atttcggacg gccgtatgaa     1020

ggcatcgccg tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac     1080

aaaattatcg acgagcgcct gatcaacccc gacggctccc tgctgttccg agtaaccatc     1140

aacggagtga ccggctggcg gctgtgcgaa cgcattctgg cgggtggcgg ttctggtgtg     1200

tccaagggcg aagaggacaa catggccagc ctgcctgcca cccacgagct gcacatcttc     1260

ggcagcatca acggcgtgga cttcgacatg gtgggacagg gcaccggcaa ccccaacgac     1320

ggctacgagg aactgaacct gaagtccaca aagggcgacc tgcagttcag cccctggatt     1380

ctggtgcccc acatcggcta cggcttccac cagtacctgc cctaccccga cggcatgagc     1440

cctttccagg ccgctatggt ggatggcagc ggctaccagg tgcaccggac catgcagttt     1500

gaggacggcg ccagcctgac cgtgaactac cggtacacat acgagggcag ccacatcaag     1560

ggcgaggccc aagtgaaggg cacaggcttt ccagccgacg gccccgtgat gaccaatagc     1620

ctgacagccg ccgactggtg cagaagcaag aaaacctacc ccaatgacaa gaccatcatc     1680

agcaccttca agtggtccta caccaccggc aatggcaagc ggtacagaag caccgcccgg     1740

accacctaca ccttcgccaa acctatggcc gccaactacc tgaagaacca gcctatgtac     1800

gtgttccgca agaccgagct gaagcactcc aagacagaac tgaacttcaa agagtggcag     1860

aaagccttca cctaa                                                      1875


<210>  8
<211>  624
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mNeon_green-nLuc-mNeon_green

<400>  8

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ser Leu Pro Ala Thr 
1               5                   10                  15      


His Glu Leu His Ile Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met 
            20                  25                  30          


Val Gly Gln Gly Thr Gly Asn Pro Asn Asp Gly Tyr Glu Glu Leu Asn 
        35                  40                  45              


Leu Lys Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val 
    50                  55                  60                  


Pro His Ile Gly Tyr Gly Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly 
65                  70                  75                  80  


Met Ser Pro Phe Gln Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val 
                85                  90                  95      


His Arg Thr Met Gln Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr 
            100                 105                 110         


Arg Tyr Thr Tyr Glu Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys 
        115                 120                 125             


Gly Thr Gly Phe Pro Ala Asp Gly Pro Val Met Thr Asn Ser Leu Thr 
    130                 135                 140                 


Ala Ala Asp Trp Cys Arg Ser Lys Lys Thr Tyr Pro Asn Asp Lys Thr 
145                 150                 155                 160 


Ile Ile Ser Thr Phe Lys Trp Ser Tyr Thr Thr Gly Asn Gly Lys Arg 
                165                 170                 175     


Tyr Arg Ser Thr Ala Arg Thr Thr Tyr Thr Phe Ala Lys Pro Met Ala 
            180                 185                 190         


Ala Asn Tyr Leu Lys Asn Gln Pro Met Tyr Val Phe Arg Lys Thr Glu 
        195                 200                 205             


Leu Lys His Ser Lys Thr Glu Leu Asn Phe Lys Glu Trp Gln Lys Ala 
    210                 215                 220                 


Phe Thr Gly Phe Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
                245                 250                 255     


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
            260                 265                 270         


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
        275                 280                 285             


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
    290                 295                 300                 


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
305                 310                 315                 320 


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
                325                 330                 335     


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
            340                 345                 350         


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
        355                 360                 365             


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
    370                 375                 380                 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly Ser Gly Val 
385                 390                 395                 400 


Ser Lys Gly Glu Glu Asp Asn Met Ala Ser Leu Pro Ala Thr His Glu 
                405                 410                 415     


Leu His Ile Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met Val Gly 
            420                 425                 430         


Gln Gly Thr Gly Asn Pro Asn Asp Gly Tyr Glu Glu Leu Asn Leu Lys 
        435                 440                 445             


Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val Pro His 
    450                 455                 460                 


Ile Gly Tyr Gly Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly Met Ser 
465                 470                 475                 480 


Pro Phe Gln Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val His Arg 
                485                 490                 495     


Thr Met Gln Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr Arg Tyr 
            500                 505                 510         


Thr Tyr Glu Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys Gly Thr 
        515                 520                 525             


Gly Phe Pro Ala Asp Gly Pro Val Met Thr Asn Ser Leu Thr Ala Ala 
    530                 535                 540                 


Asp Trp Cys Arg Ser Lys Lys Thr Tyr Pro Asn Asp Lys Thr Ile Ile 
545                 550                 555                 560 


Ser Thr Phe Lys Trp Ser Tyr Thr Thr Gly Asn Gly Lys Arg Tyr Arg 
                565                 570                 575     


Ser Thr Ala Arg Thr Thr Tyr Thr Phe Ala Lys Pro Met Ala Ala Asn 
            580                 585                 590         


Tyr Leu Lys Asn Gln Pro Met Tyr Val Phe Arg Lys Thr Glu Leu Lys 
        595                 600                 605             


His Ser Lys Thr Glu Leu Asn Phe Lys Glu Trp Gln Lys Ala Phe Thr 
    610                 615                 620                 


<210>  9
<211>  1884
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mNeon_green-nLuc-mTurquoise

<400>  9
atggtgtcca agggcgaaga ggacaacatg gccagcctgc ctgccaccca cgagctgcac       60

atcttcggca gcatcaacgg cgtggacttc gacatggtgg gacagggcac cggcaacccc      120

aacgacggct acgaggaact gaacctgaag tccacaaagg gcgacctgca gttcagcccc      180

tggattctgg tgccccacat cggctacggc ttccaccagt acctgcccta ccccgacggc      240

atgagccctt tccaggccgc tatggtggat ggcagcggct accaggtgca ccggaccatg      300

cagtttgagg acggcgccag cctgaccgtg aactaccggt acacatacga gggcagccac      360

atcaagggcg aggcccaagt gaagggcaca ggctttccag ccgacggccc cgtgatgacc      420

aatagcctga cagccgccga ctggtgcaga agcaagaaaa cctaccccaa tgacaagacc      480

atcatcagca ccttcaagtg gtcctacacc accggcaatg gcaagcggta cagaagcacc      540

gcccggacca cctacacctt cgccaaacct atggccgcca actacctgaa gaaccagcct      600

atgtacgtgt tccgcaagac cgagctgaag cactccaaga cagaactgaa cttcaaagag      660

tggcagaaag ccttcaccgg gtttgaagat ttcgttgggg actggcgaca gacagccggc      720

tacaacctgg accaagtcct tgaacaggga ggtgtgtcca gtttgtttca gaatctcggg      780

gtgtccgtaa ctccgatcca aaggattgtc ctgagcggtg aaaatgggct gaagatcgac      840

atccatgtca tcatcccgta tgaaggtctg agcggcgacc aaatgggcca gatcgaaaaa      900

atttttaagg tggtgtaccc tgtggatgat catcacttta aggtgatcct gcactatggc      960

acactggtaa tcgacggggt tacgccgaac atgatcgact atttcggacg gccgtatgaa     1020

ggcatcgccg tgttcgacgg caaaaagatc actgtaacag ggaccctgtg gaacggcaac     1080

aaaattatcg acgagcgcct gatcaacccc gacggctccc tgctgttccg agtaaccatc     1140

aacggagtga ccggctggcg gctgtgcgaa cgcattctgg cgggtggcgg ttctggtgtg     1200

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac     1260

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag     1320

ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg     1380

accaccctgt cctggggcgt gcagtgcttc gcccgctacc ccgaccacat gaagcagcac     1440

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag     1500

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac     1560

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg     1620

gagtacaact actttagcga caacgtctat atcaccgccg acaagcagaa gaacggcatc     1680

aaggccaact tcaagatccg ccacaacatc gaggacggcg gcgtgcagct cgccgaccac     1740

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg     1800

agcacccagt ccaagctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg     1860

gagttcgtga ccgccgccgg gtaa                                            1884


<210>  10
<211>  627
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mNeon_green-nLuc-mTurquoise

<400>  10

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ser Leu Pro Ala Thr 
1               5                   10                  15      


His Glu Leu His Ile Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met 
            20                  25                  30          


Val Gly Gln Gly Thr Gly Asn Pro Asn Asp Gly Tyr Glu Glu Leu Asn 
        35                  40                  45              


Leu Lys Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val 
    50                  55                  60                  


Pro His Ile Gly Tyr Gly Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly 
65                  70                  75                  80  


Met Ser Pro Phe Gln Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val 
                85                  90                  95      


His Arg Thr Met Gln Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr 
            100                 105                 110         


Arg Tyr Thr Tyr Glu Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys 
        115                 120                 125             


Gly Thr Gly Phe Pro Ala Asp Gly Pro Val Met Thr Asn Ser Leu Thr 
    130                 135                 140                 


Ala Ala Asp Trp Cys Arg Ser Lys Lys Thr Tyr Pro Asn Asp Lys Thr 
145                 150                 155                 160 


Ile Ile Ser Thr Phe Lys Trp Ser Tyr Thr Thr Gly Asn Gly Lys Arg 
                165                 170                 175     


Tyr Arg Ser Thr Ala Arg Thr Thr Tyr Thr Phe Ala Lys Pro Met Ala 
            180                 185                 190         


Ala Asn Tyr Leu Lys Asn Gln Pro Met Tyr Val Phe Arg Lys Thr Glu 
        195                 200                 205             


Leu Lys His Ser Lys Thr Glu Leu Asn Phe Lys Glu Trp Gln Lys Ala 
    210                 215                 220                 


Phe Thr Gly Phe Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
225                 230                 235                 240 


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
                245                 250                 255     


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
            260                 265                 270         


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
        275                 280                 285             


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
    290                 295                 300                 


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
305                 310                 315                 320 


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
                325                 330                 335     


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
            340                 345                 350         


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
        355                 360                 365             


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
    370                 375                 380                 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly Ser Gly Val 
385                 390                 395                 400 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
                405                 410                 415     


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            420                 425                 430         


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        435                 440                 445             


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser 
    450                 455                 460                 


Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
465                 470                 475                 480 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                485                 490                 495     


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            500                 505                 510         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        515                 520                 525             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    530                 535                 540                 


Phe Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
545                 550                 555                 560 


Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln 
                565                 570                 575     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            580                 585                 590         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys 
        595                 600                 605             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    610                 615                 620                 


Ala Ala Gly 
625         


<210>  11
<211>  1893
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mTurquoise-nLuc-mNeon_green

<400>  11
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgtcctg gggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactactt tagcgacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggttg catacactcg aagatttcgt tggggactgg      720

cgacagacag ccggctacaa cctggaccaa gtccttgaac agggaggtgt gtccagtttg      780

tttcagaatc tcggggtgtc cgtaactccg atccaaagga ttgtcctgag cggtgaaaat      840

gggctgaaga tcgacatcca tgtcatcatc ccgtatgaag gtctgagcgg cgaccaaatg      900

ggccagatcg aaaaaatttt taaggtggtg taccctgtgg atgatcatca ctttaaggtg      960

atcctgcact atggcacact ggtaatcgac ggggttacgc cgaacatgat cgactatttc     1020

ggacggccgt atgaaggcat cgccgtgttc gacggcaaaa agatcactgt aacagggacc     1080

ctgtggaacg gcaacaaaat tatcgacgag cgcctgatca accccgacgg ctccctgctg     1140

ttccgagtaa ccatcaacgg agtgaccggc tggcggctgt gcgaacgcat tctggcgggt     1200

ggcggttctg gtatggtgtc caagggcgaa gaggacaaca tggccagcct gcctgccacc     1260

cacgagctgc acatcttcgg cagcatcaac ggcgtggact tcgacatggt gggacagggc     1320

accggcaacc ccaacgacgg ctacgaggaa ctgaacctga agtccacaaa gggcgacctg     1380

cagttcagcc cctggattct ggtgccccac atcggctacg gcttccacca gtacctgccc     1440

taccccgacg gcatgagccc tttccaggcc gctatggtgg atggcagcgg ctaccaggtg     1500

caccggacca tgcagtttga ggacggcgcc agcctgaccg tgaactaccg gtacacatac     1560

gagggcagcc acatcaaggg cgaggcccaa gtgaagggca caggctttcc agccgacggc     1620

cccgtgatga ccaatagcct gacagccgcc gactggtgca gaagcaagaa aacctacccc     1680

aatgacaaga ccatcatcag caccttcaag tggtcctaca ccaccggcaa tggcaagcgg     1740

tacagaagca ccgcccggac cacctacacc ttcgccaaac ctatggccgc caactacctg     1800

aagaaccagc ctatgtacgt gttccgcaag accgagctga agcactccaa gacagaactg     1860

aacttcaaag agtggcagaa agccttcacc taa                                  1893


<210>  12
<211>  630
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mTurquoise-nLuc-mNeon_green

<400>  12

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Phe Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Leu His Thr Leu Glu Asp Phe Val Gly Asp Trp 
225                 230                 235                 240 


Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly 
                245                 250                 255     


Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln 
            260                 265                 270         


Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val 
        275                 280                 285             


Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu 
    290                 295                 300                 


Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
305                 310                 315                 320 


Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
                325                 330                 335     


Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
            340                 345                 350         


Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
        355                 360                 365             


Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
    370                 375                 380                 


Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ser 
                405                 410                 415     


Leu Pro Ala Thr His Glu Leu His Ile Phe Gly Ser Ile Asn Gly Val 
            420                 425                 430         


Asp Phe Asp Met Val Gly Gln Gly Thr Gly Asn Pro Asn Asp Gly Tyr 
        435                 440                 445             


Glu Glu Leu Asn Leu Lys Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro 
    450                 455                 460                 


Trp Ile Leu Val Pro His Ile Gly Tyr Gly Phe His Gln Tyr Leu Pro 
465                 470                 475                 480 


Tyr Pro Asp Gly Met Ser Pro Phe Gln Ala Ala Met Val Asp Gly Ser 
                485                 490                 495     


Gly Tyr Gln Val His Arg Thr Met Gln Phe Glu Asp Gly Ala Ser Leu 
            500                 505                 510         


Thr Val Asn Tyr Arg Tyr Thr Tyr Glu Gly Ser His Ile Lys Gly Glu 
        515                 520                 525             


Ala Gln Val Lys Gly Thr Gly Phe Pro Ala Asp Gly Pro Val Met Thr 
    530                 535                 540                 


Asn Ser Leu Thr Ala Ala Asp Trp Cys Arg Ser Lys Lys Thr Tyr Pro 
545                 550                 555                 560 


Asn Asp Lys Thr Ile Ile Ser Thr Phe Lys Trp Ser Tyr Thr Thr Gly 
                565                 570                 575     


Asn Gly Lys Arg Tyr Arg Ser Thr Ala Arg Thr Thr Tyr Thr Phe Ala 
            580                 585                 590         


Lys Pro Met Ala Ala Asn Tyr Leu Lys Asn Gln Pro Met Tyr Val Phe 
        595                 600                 605             


Arg Lys Thr Glu Leu Lys His Ser Lys Thr Glu Leu Asn Phe Lys Glu 
    610                 615                 620                 


Trp Gln Lys Ala Phe Thr 
625                 630 


<210>  13
<211>  1899
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mTurquoise-nLuc-mTurquoise

<400>  13
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgtcctg gggcgtgcag tgcttcgccc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactactt tagcgacaac gtctatatca ccgccgacaa gcagaagaac      480

ggcatcaagg ccaacttcaa gatccgccac aacatcgagg acggcggcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccaa gctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggttg catacactcg aagatttcgt tggggactgg      720

cgacagacag ccggctacaa cctggaccaa gtccttgaac agggaggtgt gtccagtttg      780

tttcagaatc tcggggtgtc cgtaactccg atccaaagga ttgtcctgag cggtgaaaat      840

gggctgaaga tcgacatcca tgtcatcatc ccgtatgaag gtctgagcgg cgaccaaatg      900

ggccagatcg aaaaaatttt taaggtggtg taccctgtgg atgatcatca ctttaaggtg      960

atcctgcact atggcacact ggtaatcgac ggggttacgc cgaacatgat cgactatttc     1020

ggacggccgt atgaaggcat cgccgtgttc gacggcaaaa agatcactgt aacagggacc     1080

ctgtggaacg gcaacaaaat tatcgacgag cgcctgatca accccgacgg ctccctgctg     1140

ttccgagtaa ccatcaacgg agtgaccggc tggcggctgt gcgaacgcat tctggcggtg     1200

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac     1260

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag     1320

ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg     1380

accaccctgt cctggggcgt gcagtgcttc gcccgctacc ccgaccacat gaagcagcac     1440

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag     1500

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac     1560

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg     1620

gagtacaact actttagcga caacgtctat atcaccgccg acaagcagaa gaacggcatc     1680

aaggccaact tcaagatccg ccacaacatc gaggacggcg gcgtgcagct cgccgaccac     1740

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg     1800

agcacccagt ccaagctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg     1860

gagttcgtga ccgccgccgg gggtggcggt ggttcttaa                            1899


<210>  14
<211>  632
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mTurquoise-nLuc-mTurquoise

<400>  14

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Ser Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Phe Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Leu His Thr Leu Glu Asp Phe Val Gly Asp Trp 
225                 230                 235                 240 


Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly 
                245                 250                 255     


Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln 
            260                 265                 270         


Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val 
        275                 280                 285             


Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu 
    290                 295                 300                 


Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
305                 310                 315                 320 


Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
                325                 330                 335     


Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
            340                 345                 350         


Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
        355                 360                 365             


Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
    370                 375                 380                 


Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Val 
385                 390                 395                 400 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
                405                 410                 415     


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            420                 425                 430         


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        435                 440                 445             


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Ser 
    450                 455                 460                 


Trp Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
465                 470                 475                 480 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                485                 490                 495     


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            500                 505                 510         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        515                 520                 525             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    530                 535                 540                 


Phe Ser Asp Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn Gly Ile 
545                 550                 555                 560 


Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Gly Val Gln 
                565                 570                 575     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            580                 585                 590         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Lys Leu Ser Lys 
        595                 600                 605             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    610                 615                 620                 


Ala Ala Gly Gly Gly Gly Gly Ser 
625                 630         


<210>  15
<211>  1884
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Antares2

<400>  15
atggtgagca agggcgagga gctgatcaag gagaacatga gaagcaagct gtacctggaa       60

ggcagcgtga acggccacca gttcaagtgc acccacgaag gggagggcaa gccctacgag      120

ggcaagcaga ccaacaggat caaggtggtg gagggaggcc ccctgccgtt cgcattcgac      180

atcctggcca cccactttat gtacgggagc aaggtgttca tcaagtaccc cgccgacctc      240

cccgattatt ttaagcagtc cttccctgag ggcttcacat gggagagagt catggtgttc      300

gaagacgggg gcgtgctgac cgccacccag gacaccagcc tccaggacgg cgagctcatc      360

tacaacgtca aggtcagagg ggtgaacttc ccagccaacg gccccgtgat gcagaagaaa      420

acactgggct gggagcccag caccgagacc atgtaccccg ctgacggcgg cctggaaggc      480

agatgcgaca aggccctgaa gctcgtgggc gggggccacc tgcacgtcaa cttcaagacc      540

acatacaagt ccaagaaacc cgtgaagatg cccggcgtcc actacgtgga ccgcagactg      600

gaaagaatca aggaggccga caacgagacc tacgtcgagc agtacgagca cgctgtggcc      660

agatactcca acctgggcgg aggcttcaca ctcgaagatt tcgttgggga ctggcgacag      720

acagccggct acaacctgag tcaagtcctt gaacagggag gtgtgtccag tttgtttcag      780

aatctcgggg tgtccgtaac tccgatccaa aggattgtcc tgagcggtga aaatgggctg      840

aagatcgaca tccatgtcat catcccgtat gaaggtctga gcggcgacca aatgggccag      900

atcgaaaaaa tttttaaggt ggtgtaccct gtggataatc atcactttaa ggtgatcctg      960

cactatggca cactggtaat cgacggggtt acgccgaaca tgatcgacta tttcggacgg     1020

ccgtatgaag gcatcgccgt gttcgacggc aaaaagatca ctgtaacagg gaccctgtgg     1080

aacggcaaca aaattatcga cgagcgcctg atcaaccccg acggctccct gctgttccga     1140

gtaaccatca acggagtgac cggctggcgt ctgcatgaac gcattctggc gaggcacgag     1200

ctgatcaagg agaacatgag aagcaagctg tacctggaag gcagcgtgaa cggccaccag     1260

ttcaagtgca cccacgaagg ggagggcaag ccctacgagg gcaagcagac caacaggatc     1320

aaggtggtgg agggaggccc cctgccgttc gcattcgaca tcctggccac ccactttatg     1380

tacgggagca aggtgttcat caagtacccc gccgacctcc ccgattattt taagcagtcc     1440

ttccctgagg gcttcacatg ggagagagtc atggtgttcg aagacggggg cgtgctgacc     1500

gccacccagg acaccagcct ccaggacggc gagctcatct acaacgtcaa ggtcagaggg     1560

gtgaacttcc cagccaacgg ccccgtgatg cagaagaaaa cactgggctg ggagcccagc     1620

accgagacca tgtaccccgc tgacggcggc ctggaaggca gatgcgacaa ggccctgaag     1680

ctcgtgggcg ggggccacct gcacgtcaac ttcaagacca catacaagtc caagaaaccc     1740

gtgaagatgc ccggcgtcca ctacgtggac cgcagactgg aaagaatcaa ggaggccgac     1800

aacgagacct acgtcgagca gtacgagcac gctgtggcca gatactccaa cctgggcgga     1860

ggcatggacg agctgtacaa gtaa                                            1884


<210>  16
<211>  627
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antares2

<400>  16

Met Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met Arg Ser Lys 
1               5                   10                  15      


Leu Tyr Leu Glu Gly Ser Val Asn Gly His Gln Phe Lys Cys Thr His 
            20                  25                  30          


Glu Gly Glu Gly Lys Pro Tyr Glu Gly Lys Gln Thr Asn Arg Ile Lys 
        35                  40                  45              


Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr 
    50                  55                  60                  


His Phe Met Tyr Gly Ser Lys Val Phe Ile Lys Tyr Pro Ala Asp Leu 
65                  70                  75                  80  


Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg 
                85                  90                  95      


Val Met Val Phe Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr 
            100                 105                 110         


Ser Leu Gln Asp Gly Glu Leu Ile Tyr Asn Val Lys Val Arg Gly Val 
        115                 120                 125             


Asn Phe Pro Ala Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp 
    130                 135                 140                 


Glu Pro Ser Thr Glu Thr Met Tyr Pro Ala Asp Gly Gly Leu Glu Gly 
145                 150                 155                 160 


Arg Cys Asp Lys Ala Leu Lys Leu Val Gly Gly Gly His Leu His Val 
                165                 170                 175     


Asn Phe Lys Thr Thr Tyr Lys Ser Lys Lys Pro Val Lys Met Pro Gly 
            180                 185                 190         


Val His Tyr Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala Asp Asn 
        195                 200                 205             


Glu Thr Tyr Val Glu Gln Tyr Glu His Ala Val Ala Arg Tyr Ser Asn 
    210                 215                 220                 


Leu Gly Gly Gly Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 
225                 230                 235                 240 


Thr Ala Gly Tyr Asn Leu Ser Gln Val Leu Glu Gln Gly Gly Val Ser 
                245                 250                 255     


Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 
            260                 265                 270         


Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 
        275                 280                 285             


Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 
    290                 295                 300                 


Phe Lys Val Val Tyr Pro Val Asp Asn His His Phe Lys Val Ile Leu 
305                 310                 315                 320 


His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 
                325                 330                 335     


Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 
            340                 345                 350         


Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 
        355                 360                 365             


Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 
    370                 375                 380                 


Gly Val Thr Gly Trp Arg Leu His Glu Arg Ile Leu Ala Arg His Glu 
385                 390                 395                 400 


Leu Ile Lys Glu Asn Met Arg Ser Lys Leu Tyr Leu Glu Gly Ser Val 
                405                 410                 415     


Asn Gly His Gln Phe Lys Cys Thr His Glu Gly Glu Gly Lys Pro Tyr 
            420                 425                 430         


Glu Gly Lys Gln Thr Asn Arg Ile Lys Val Val Glu Gly Gly Pro Leu 
        435                 440                 445             


Pro Phe Ala Phe Asp Ile Leu Ala Thr His Phe Met Tyr Gly Ser Lys 
    450                 455                 460                 


Val Phe Ile Lys Tyr Pro Ala Asp Leu Pro Asp Tyr Phe Lys Gln Ser 
465                 470                 475                 480 


Phe Pro Glu Gly Phe Thr Trp Glu Arg Val Met Val Phe Glu Asp Gly 
                485                 490                 495     


Gly Val Leu Thr Ala Thr Gln Asp Thr Ser Leu Gln Asp Gly Glu Leu 
            500                 505                 510         


Ile Tyr Asn Val Lys Val Arg Gly Val Asn Phe Pro Ala Asn Gly Pro 
        515                 520                 525             


Val Met Gln Lys Lys Thr Leu Gly Trp Glu Pro Ser Thr Glu Thr Met 
    530                 535                 540                 


Tyr Pro Ala Asp Gly Gly Leu Glu Gly Arg Cys Asp Lys Ala Leu Lys 
545                 550                 555                 560 


Leu Val Gly Gly Gly His Leu His Val Asn Phe Lys Thr Thr Tyr Lys 
                565                 570                 575     


Ser Lys Lys Pro Val Lys Met Pro Gly Val His Tyr Val Asp Arg Arg 
            580                 585                 590         


Leu Glu Arg Ile Lys Glu Ala Asp Asn Glu Thr Tyr Val Glu Gln Tyr 
        595                 600                 605             


Glu His Ala Val Ala Arg Tyr Ser Asn Leu Gly Gly Gly Met Asp Glu 
    610                 615                 620                 


Leu Tyr Lys 
625         


<210>  17
<211>  692
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Antares

<400>  17
tggtgagcaa gggcgaggag ctgatcaagg agaacatgag aagcaagctg tacctggaag       60

gcagcgtgaa cggccaccag ttcaagtgca cccacgaagg ggagggcaag ccctacgagg      120

gcaagcagac caacaggatc aaggtggtgg agggaggccc cctgccgttc gcattcgaca      180

tcctggccac ccactttatg tacgggagca aggtgttcat caagtacccc gccgacctcc      240

ccgattattt taagcagtcc ttccctgagg gcttcacatg ggagagagtc atggtgttcg      300

aagacggggg cgtgctgacc gccacccagg acaccagcct ccaggacggc gagctcatct      360

acaacgtcaa ggtcagaggg gtgaacttcc cagccaacgg ccccgtgatg cagaagaaaa      420

cactgggctg ggagcccagc accgagacca tgtaccccgc tgacggcggc ctggaaggca      480

gatgcgacaa ggccctgaag ctcgtgggcg ggggccacct gcacgtcaac ttcaagacca      540

catacaagtc caagaaaccc gtgaagatgc ccggcgtcca ctacgtggac cgcagactgg      600

aaagaatcaa ggaggccgac aacgagacct acgtcgagca gtacgagcac gctgtggcca      660

gatactccaa cctgggcgga ggcttcacac tc                                    692


<210>  18
<211>  231
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Antares

<400>  18

Met Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met Arg Ser Lys 
1               5                   10                  15      


Leu Tyr Leu Glu Gly Ser Val Asn Gly His Gln Phe Lys Cys Thr His 
            20                  25                  30          


Glu Gly Glu Gly Lys Pro Tyr Glu Gly Lys Gln Thr Asn Arg Ile Lys 
        35                  40                  45              


Val Val Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr 
    50                  55                  60                  


His Phe Met Tyr Gly Ser Lys Val Phe Ile Lys Tyr Pro Ala Asp Leu 
65                  70                  75                  80  


Pro Asp Tyr Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg 
                85                  90                  95      


Val Met Val Phe Glu Asp Gly Gly Val Leu Thr Ala Thr Gln Asp Thr 
            100                 105                 110         


Ser Leu Gln Asp Gly Glu Leu Ile Tyr Asn Val Lys Val Arg Gly Val 
        115                 120                 125             


Asn Phe Pro Ala Asn Gly Pro Val Met Gln Lys Lys Thr Leu Gly Trp 
    130                 135                 140                 


Glu Pro Ser Thr Glu Thr Met Tyr Pro Ala Asp Gly Gly Leu Glu Gly 
145                 150                 155                 160 


Arg Cys Asp Lys Ala Leu Lys Leu Val Gly Gly Gly His Leu His Val 
                165                 170                 175     


Asn Phe Lys Thr Thr Tyr Lys Ser Lys Lys Pro Val Lys Met Pro Gly 
            180                 185                 190         


Val His Tyr Val Asp Arg Arg Leu Glu Arg Ile Lys Glu Ala Asp Asn 
        195                 200                 205             


Glu Thr Tyr Val Glu Gln Tyr Glu His Ala Val Ala Arg Tyr Ser Asn 
    210                 215                 220                 


Leu Gly Gly Gly Phe Thr Leu 
225                 230     


<210>  19
<211>  501
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Nanoluciferase

<400>  19
gaagatttcg ttggggactg gcgacagaca gccggctaca acctggacca agtccttgaa       60

cagggaggtg tgtccagttt gtttcagaat ctcggggtgt ccgtaactcc gatccaaagg      120

attgtcctga gcggtgaaaa tgggctgaag atcgacatcc atgtcatcat cccgtatgaa      180

ggtctgagcg gcgaccaaat gggccagatc gaaaaaattt ttaaggtggt gtaccctgtg      240

gatgatcatc actttaaggt gatcctgcac tatggcacac tggtaatcga cggggttacg      300

ccgaacatga tcgactattt cggacggccg tatgaaggca tcgccgtgtt cgacggcaaa      360

aagatcactg taacagggac cctgtggaac ggcaacaaaa ttatcgacga gcgcctgatc      420

aaccccgacg gctccctgct gttccgagta accatcaacg gagtgaccgg ctggcggctg      480

tgcgaacgca ttctggcgta a                                                501


<210>  20
<211>  166
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Nanoluciferase

<400>  20

Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp 
1               5                   10                  15      


Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly 
            20                  25                  30          


Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly 
        35                  40                  45              


Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly 
    50                  55                  60                  


Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val 
65                  70                  75                  80  


Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile 
                85                  90                  95      


Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu 
            100                 105                 110         


Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu 
        115                 120                 125             


Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly 
    130                 135                 140                 


Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg Leu 
145                 150                 155                 160 


Cys Glu Arg Ile Leu Ala 
                165     


<210>  21
<211>  516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  teLuc

<400>  21
atggtcttca cactcgaaga tttcgttggg gactggcgac agacagccgg ctacaacttg       60

agtcaagtcc ttgaacaggg aggtgtgtcc agtttgtttc agaatctcgg ggtgtccgta      120

actccgatcc aaaggattgt cctgagcggt gaaaatgggc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcggcgac caaatgggcc agatcgaaaa aatttttaag      240

gtggtgtacc ctgtggataa tcatcacttt aaggtgatcc tgcactatgg cacactggta      300

atcgacgggg ttacgccgaa catgatcgac tatttcggac ggccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc tgatcaaccc cgacggctcc ctgctgttcc gagtaaccat caacggagtg      480

accggctggc gtctgcatga acgcattctg gcgtaa                                516


<210>  22
<211>  516
<212>  DNA
<213>  Artificial sequence

<220>
<223>  yeLuc

<400>  22
atggtcctca ctctcgaaga tttcgttggg gactggcgac agacagacgg ctataaccag       60

gctcaagtcc ttgaacaggg aggtttgacc agtttgtttc agaacctcgg ggtgtccgta      120

actccgatcc aaaggattgt cctgagcggt gaaaatgggc tgaagatcga catccatgtc      180

atcatcccgt atgaaggtct gagcggcgac cgaatgggcc agatcgaaaa aatttttaag      240

gtggtgtacc ctgtggatga tcatcatttt aaggtgatcc tgcactatgg cacactggta      300

atcgacgggg ttacgccgaa catgatcgac tatttcggac agccgtatga aggcatcgcc      360

gtgttcgacg gcaaaaagat cactgtaaca gggaccctgt ggaacggcaa caaaattatc      420

gacgagcgcc ggatcaaccc cgacggctcc ctgctgttcc gagtaaccat caacggagtg      480

accggctggc gtctgagtga acgcattctg gcgtaa                                516


