                         SEQUENCE LISTING

<110>  THE HOSPITAL FOR SICK CHILDREN
 
<120>  SARS-COV-2 CONSTRUCT, VACCINES, AND METHODS

<130>  3206-5045 (169477) ELL

<140>  PCT/CA2021/051581
<141>  2021-11-05

<150>  US 63/110881
<151>  2020-11-06

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric H chain + RBD

<400>  1

Met Ala Leu Leu Val Leu Phe Leu Ser Leu Ala Ala Phe Pro Ser Cys 
1               5                   10                  15      


Gly Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
        35                  40                  45              


Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Ile Asn Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Phe Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Ser Ser Leu Gln Thr Asp Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Gly Asp Tyr Val His Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Ala Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
                485                 490                 495     


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            500                 505                 510         


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        515                 520                 525             


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    530                 535                 540                 


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
545                 550                 555                 560 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                565                 570                 575     


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            580                 585                 590         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        595                 600                 605             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    610                 615                 620                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
625                 630                 635                 640 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                645                 650                 655     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            660                 665                 670         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        675                 680                 685             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    690                 695                 700             


<210>  2
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + RBD

<400>  2

Met Asp Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Gln Arg Val Ser Leu Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Glu Ile Ser Gly Tyr Leu Thr Trp Leu Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Ile Lys Arg Leu Val Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Thr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
                245                 250                 255     


Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            260                 265                 270         


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        275                 280                 285             


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    290                 295                 300                 


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
305                 310                 315                 320 


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                325                 330                 335     


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            340                 345                 350         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        355                 360                 365             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    370                 375                 380                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
385                 390                 395                 400 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                405                 410                 415     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            420                 425                 430         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        435                 440                 445             


Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn 
    450                 455                 460                 


Lys Cys Val Asn Phe 
465                 


<210>  3
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + TpD

<400>  3

Met Asp Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Gln Arg Val Ser Leu Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Glu Ile Ser Gly Tyr Leu Thr Trp Leu Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Ile Lys Arg Leu Val Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Thr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Ile Leu Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
                245                 250                 255     


Ile Pro Met Gly Leu Pro Gln Ser Ile Ala Leu Ser Ser Leu Met Val 
            260                 265                 270         


Ala Gln 
        


<210>  4

<400>  4
000

<210>  5
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric H chain

<400>  5

Met Ala Leu Leu Val Leu Phe Leu Ser Leu Ala Ala Phe Pro Ser Cys 
1               5                   10                  15      


Gly Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
        35                  40                  45              


Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Ile Asn Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Phe Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Ser Ser Leu Gln Thr Asp Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Gly Asp Tyr Val His Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Ala Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  6
<211>  1410
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric H chain

<400>  6
atggctctgc tggtgctgtt tctgagcctg gccgcctttc cttcttgtgg cgtgctgtct       60

caggtgcagc tgaaagagtc tggccctgga ctggtggccc caagccagtc tctgagcatc      120

acctgtaccg tgtccggctt cagcctgaca agctatggcg tgcactgggt ccgacagcct      180

ccaggcaaag gactggaatg gctgggagtg atttgggctg gcggcagcat caactacaac      240

agcgccctga tgagccggct gagcatctcc aaggacaact tcaagagcca ggtgttcctg      300

aagatgagca gcctgcagac cgacgacacc gccatgtact attgcgccag agcctacggc      360

gactacgtgc actacgccat ggattattgg ggccagggca caagcgtgac agccagctct      420

gcctctacaa agggccctag cgttttccca ctggctccca gcagcaagtc tacatctggc      480

ggaacagccg ctctgggctg cctggtcaag gattactttc ccgagccagt gaccgtgtcc      540

tggaattctg gcgctctgac aagcggcgtg cacacctttc cagctgtgct gcaaagcagc      600

ggcctgtact ctctgtccag cgtggtcaca gtgcctagct ctagcctggg cacccagacc      660

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagaa ggtggaaccc      720

aagagctgcg acaagaccca cacctgtcct ccatgtcctg ctccagaact gctcggcgga      780

ccttccgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct      840

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggatc ccgaagtgaa gttcaattgg      900

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac      960

agcacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa     1020

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctatcgagaa aaccatcagc     1080

aaggccaagg gccagcctag ggaaccccag gtttacacac tgcctccaag cagggacgag     1140

ctgaccaaga atcaggtgtc cctgacctgc ctcgtgaagg gcttctaccc ttccgatatc     1200

gccgtggaat gggagagcaa tggccagcct gagaacaact acaagacaac ccctcctgtg     1260

ctggacagcg acggctcatt cttcctgtac agcaagctga cagtggacaa gtccagatgg     1320

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagtccc tgagcctgtc tcctggcaag                                      1410


<210>  7
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain

<400>  7

Met Asp Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Gln Arg Val Ser Leu Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Glu Ile Ser Gly Tyr Leu Thr Trp Leu Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Ile Lys Arg Leu Val Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Thr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210>  8
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain

<400>  8
atggacatga gagtgcctgc tcacgtgttc ggctttctgc tgctgtggtt ccctggcacc       60

agatgcgaca tccagatgac acagagcccc agcagcctgt ctgcctctct gggacagaga      120

gtgtccctga cctgtagagc cagccaagag atcagcggct acctgacatg gctgcagcag      180

aagcctgacg gcaccatcaa gagactggtg tacgccgcca gcacactgga tagcggagtg      240

cccaagagat tctccggcag cagatccggc agcgactaca gcctgacaat cagctccctg      300

gaaagcgagg acttcgccga ctactactgc ctgcagtaca caaactaccc tctgaccttc      360

ggagccggca ccaagctgga actgaagaga acagtggccg ctcctagcgt gttcatcttc      420

ccaccttccg acgagcagct gaagtctggc acagcctctg tcgtgtgcct gctgaacaac      480

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaat      540

agccaagagt ctgtgaccga gcaggacagc aaggactcca cctatagcct gagcagcacc      600

ctgacactga gcaaggccga ctacgagaag cacaaagtgt acgcctgcga agtgacccac      660

cagggccttt ctagccctgt gaccaagagc ttcaaccggg gcgagtgt                   708


<210>  9
<211>  703
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric H chain + RBD

<400>  9

Met Ala Leu Leu Val Leu Phe Leu Ser Leu Ala Ala Phe Pro Ser Cys 
1               5                   10                  15      


Gly Val Leu Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val 
            20                  25                  30          


Ala Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser 
        35                  40                  45              


Leu Thr Ser Tyr Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Ser Ile Asn Tyr Asn 
65                  70                  75                  80  


Ser Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn Phe Lys Ser 
                85                  90                  95      


Gln Val Phe Leu Lys Met Ser Ser Leu Gln Thr Asp Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Tyr Gly Asp Tyr Val His Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Ala Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
                485                 490                 495     


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            500                 505                 510         


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        515                 520                 525             


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    530                 535                 540                 


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
545                 550                 555                 560 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                565                 570                 575     


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            580                 585                 590         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        595                 600                 605             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    610                 615                 620                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
625                 630                 635                 640 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                645                 650                 655     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            660                 665                 670         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        675                 680                 685             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    690                 695                 700             


<210>  10
<211>  2109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric H chain + RBD

<400>  10
atggctctgc tggtgctgtt tctgagcctg gccgcctttc cttcttgtgg cgtgctgtct       60

caggtgcagc tgaaagagtc tggccctgga ctggtggccc caagccagtc tctgagcatc      120

acctgtaccg tgtccggctt cagcctgaca agctatggcg tgcactgggt ccgacagcct      180

ccaggcaaag gactggaatg gctgggagtg atttgggctg gcggcagcat caactacaac      240

agcgccctga tgagccggct gagcatctcc aaggacaact tcaagagcca ggtgttcctg      300

aagatgagca gcctgcagac cgacgacacc gccatgtact attgcgccag agcctacggc      360

gactacgtgc actacgccat ggattattgg ggccagggca caagcgtgac agccagctct      420

gcctctacaa agggccctag cgttttccca ctggctccca gcagcaagtc tacatctggc      480

ggaacagccg ctctgggctg cctggtcaag gattactttc ccgagccagt gaccgtgtcc      540

tggaattctg gcgctctgac aagcggcgtg cacacctttc cagctgtgct gcaaagcagc      600

ggcctgtact ctctgtccag cgtggtcaca gtgcctagct ctagcctggg cacccagacc      660

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagaa ggtggaaccc      720

aagagctgcg acaagaccca cacctgtcct ccatgtcctg ctccagaact gctcggcgga      780

ccttccgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct      840

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggatc ccgaagtgaa gttcaattgg      900

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac      960

agcacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa     1020

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctatcgagaa aaccatcagc     1080

aaggccaagg gccagcctag ggaaccccag gtttacacac tgcctccaag cagggacgag     1140

ctgaccaaga atcaggtgtc cctgacctgc ctcgtgaagg gcttctaccc ttccgatatc     1200

gccgtggaat gggagagcaa tggccagcct gagaacaact acaagacaac ccctcctgtg     1260

ctggacagcg acggctcatt cttcctgtac agcaagctga cagtggacaa gtccagatgg     1320

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa ccactacacc     1380

cagaagtccc tgagcctgtc tcctggaaaa ggcggcggag gaagtggtgg cggaggatct     1440

agagttcagc ccaccgagag catcgtgcgg ttccccaaca tcaccaatct gtgccctttc     1500

ggcgaggtgt tcaacgccac cagattcgcc tctgtgtacg cctggaaccg gaagcggatc     1560

agcaattgcg tggccgacta ctccgtgctg tacaactccg ccagcttcag caccttcaag     1620

tgctacggcg tgtcccctac caagctgaac gacctgtgct tcaccaacgt gtacgccgac     1680

agcttcgtga tcagaggcga cgaagtgcgg cagattgccc ctggacagac aggcaagatc     1740

gccgactaca attacaagct gcccgacgac ttcaccggct gcgtgatcgc ttggaacagc     1800

aacaacctgg acagcaaagt cggcgggaac tacaactacc tgtatcggct gtttcggaag     1860

tccaacctga agcctttcga gcgggacatc agcaccgaga tctatcaggc cggcagcacc     1920

ccttgcaatg gcgtcgaagg cttcaactgc tacttcccac tgcagtccta cggcttccag     1980

cctaccaatg gcgtgggcta ccagccttat agagtggtgg tgctgagctt cgagctgctg     2040

catgctcctg ccacagtgtg cggccctaag aaaagcacca atctcgtgaa gaacaaatgc     2100

gtgaacttc                                                             2109


<210>  11
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + TpD

<400>  11

Met Asp Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Gln Arg Val Ser Leu Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Glu Ile Ser Gly Tyr Leu Thr Trp Leu Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Ile Lys Arg Leu Val Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Thr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Ile Leu Met Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly 
                245                 250                 255     


Ile Pro Met Gly Leu Pro Gln Ser Ile Ala Leu Ser Ser Leu Met Val 
            260                 265                 270         


Ala Gln 
        


<210>  12
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + TpD

<400>  12
atggacatga gagtgcctgc tcacgtgttc ggctttctgc tgctgtggtt ccctggcacc       60

agatgcgaca tccagatgac acagagcccc agcagcctgt ctgcctctct gggacagaga      120

gtgtccctga cctgtagagc cagccaagag atcagcggct acctgacatg gctgcagcag      180

aagcctgacg gcaccatcaa gagactggtg tacgccgcca gcacactgga tagcggagtg      240

cccaagagat tctccggcag cagatccggc agcgactaca gcctgacaat cagctccctg      300

gaaagcgagg acttcgccga ctactactgc ctgcagtaca caaactaccc tctgaccttc      360

ggagccggca ccaagctgga actgaagaga acagtggccg ctcctagcgt gttcatcttc      420

ccaccttccg acgagcagct gaagtctggc acagcctctg tcgtgtgcct gctgaacaac      480

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaat      540

agccaagagt ctgtgaccga gcaggacagc aaggactcca cctatagcct gagcagcacc      600

ctgacactga gcaaggccga ctacgagaag cacaaagtgt acgcctgcga agtgacccac      660

cagggccttt ctagccctgt gaccaagagc ttcaacagag gcgagtgtgg tggcagcggc      720

ggctctatcc tgatgcagta catcaaggcc aacagcaagt tcatcggcat ccccatgggc      780

ctgcctcagt ctattgctct gagcagcctg atggtggccc ag                         822


<210>  13
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + PADRE

<400>  13

Met Asp Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Gln Arg Val Ser Leu Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Glu Ile Ser Gly Tyr Leu Thr Trp Leu Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Ile Lys Arg Leu Val Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Thr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Ser Gly 
225                 230                 235                 240 


Gly Ser Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
                245                 250                 255 


<210>  14
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + PADRE

<400>  14
atggacatga gagtgcctgc tcacgtgttc ggctttctgc tgctgtggtt ccctggcacc       60

agatgcgaca tccagatgac acagagcccc agcagcctgt ctgcctctct gggacagaga      120

gtgtccctga cctgtagagc cagccaagag atcagcggct acctgacatg gctgcagcag      180

aagcctgacg gcaccatcaa gagactggtg tacgccgcca gcacactgga tagcggagtg      240

cccaagagat tctccggcag cagatccggc agcgactaca gcctgacaat cagctccctg      300

gaaagcgagg acttcgccga ctactactgc ctgcagtaca caaactaccc tctgaccttc      360

ggagccggca ccaagctgga actgaagaga acagtggccg ctcctagcgt gttcatcttc      420

ccaccttccg acgagcagct gaagtctggc acagcctctg tcgtgtgcct gctgaacaac      480

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaat      540

agccaagagt ctgtgaccga gcaggacagc aaggactcca cctatagcct gagcagcacc      600

ctgacactga gcaaggccga ctacgagaag cacaaagtgt acgcctgcga agtgacccac      660

cagggccttt ctagccctgt gaccaagagc ttcaacagag gcgagtgtgg cggcagcgga      720

ggctctgcta aatttgtggc tgcctggaca ctgaaggccg ctgct                      765


<210>  15
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + RBD

<400>  15

Met Asp Met Arg Val Pro Ala His Val Phe Gly Phe Leu Leu Leu Trp 
1               5                   10                  15      


Phe Pro Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Leu Gly Gln Arg Val Ser Leu Thr Cys Arg Ala Ser 
        35                  40                  45              


Gln Glu Ile Ser Gly Tyr Leu Thr Trp Leu Gln Gln Lys Pro Asp Gly 
    50                  55                  60                  


Thr Ile Lys Arg Leu Val Tyr Ala Ala Ser Thr Leu Asp Ser Gly Val 
65                  70                  75                  80  


Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Glu Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Leu Gln 
            100                 105                 110         


Tyr Thr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
                245                 250                 255     


Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
            260                 265                 270         


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
        275                 280                 285             


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
    290                 295                 300                 


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
305                 310                 315                 320 


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
                325                 330                 335     


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
            340                 345                 350         


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
        355                 360                 365             


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
    370                 375                 380                 


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
385                 390                 395                 400 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                405                 410                 415     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
            420                 425                 430         


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
        435                 440                 445             


Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn 
    450                 455                 460                 


Lys Cys Val Asn Phe 
465                 


<210>  16
<211>  1407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric L chain + RBD

<400>  16
atggacatga gagtgcctgc tcacgtgttc ggctttctgc tgctgtggtt ccctggcacc       60

agatgcgaca tccagatgac acagagcccc agcagcctgt ctgcctctct gggacagaga      120

gtgtccctga cctgtagagc cagccaagag atcagcggct acctgacatg gctgcagcag      180

aagcctgacg gcaccatcaa gagactggtg tacgccgcca gcacactgga tagcggagtg      240

cccaagagat tctccggcag cagatccggc agcgactaca gcctgacaat cagctccctg      300

gaaagcgagg acttcgccga ctactactgc ctgcagtaca caaactaccc tctgaccttc      360

ggagccggca ccaagctgga actgaagaga acagtggccg ctcctagcgt gttcatcttc      420

ccaccttccg acgagcagct gaagtctggc acagcctctg tcgtgtgcct gctgaacaac      480

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca acgccctgca gagcggcaat      540

agccaagagt ctgtgaccga gcaggacagc aaggactcca cctatagcct gagcagcacc      600

ctgacactga gcaaggccga ctacgagaag cacaaagtgt acgcctgcga agtgacccac      660

cagggccttt ctagccctgt gaccaagagc ttcaacagag gcgaatgtgg cggcggagga      720

tctggcggag gcggatctag agttcagcct accgagagca tcgtgcggtt ccccaacatc      780

accaatctgt gccctttcgg cgaggtgttc aacgccacca gattcgccag tgtgtatgcc      840

tggaaccgga agcggatcag caactgcgtg gccgattaca gcgtgctgta caacagcgcc      900

agcttcagca ccttcaagtg ctacggcgtg tcccctacca agctgaacga cctgtgcttc      960

accaacgtgt acgctgacag cttcgtgatc cggggagatg aagtgcggca gattgcccct     1020

ggacagacag gcaagattgc cgactacaac tacaagctgc ccgacgactt caccggctgt     1080

gtgatcgcct ggaatagcaa caacctggac agcaaagtcg gcggcaacta caattacctg     1140

taccggctgt tccggaagtc caacctgaag cctttcgagc gggacatcag caccgagatc     1200

tatcaggccg gcagcacccc ttgcaatggc gtggaaggct tcaactgcta cttcccactg     1260

cagtcctacg gcttccagcc tacaaacggc gtgggctacc agccttacag agtggtggtg     1320

ctgagcttcg agctgctgca tgctcctgcc acagtgtgcg gccctaagaa aagcaccaac     1380

ctggtcaaga acaaatgcgt gaacttc                                         1407


