                         б

<110>  ϺҽҩƼ޹˾ż޹˾

<120>  SARS-CoV-2弰Ӧ

<130>  0134-PA-020

<160>  104

<170>  PatentIn version 3.5

<210>  1
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am01/Ab2001.08 LCDR1

<400>  1

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala Trp 
1               5                   10          


<210>  2
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am02 LCDR1

<400>  2

Arg Ala Ser Gln Gly Ile Trp Ser Trp Leu Ala Trp 
1               5                   10          


<210>  3
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am03 LCDR1

<400>  3

Arg Ser Ser Gln Ala Ile Phe Arg Trp Leu Ala Trp 
1               5                   10          


<210>  4
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am04/Ab2002.08Am05/Ab2002.08Am06/ LCDR1

<400>  4

Arg Ala Ser Gln Gly Ile Phe Arg Trp Leu Ala Trp 
1               5                   10          


<210>  5
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ͨʽI

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = PheSerTrp

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = ArgSer

<400>  5

Arg Xaa Ser Gln Xaa Ile Xaa Xaa Trp Leu Ala Trp 
1               5                   10          


<210>  6
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2ͨʽI

<400>  6

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  7
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am01/Ab2002.08Am02 LCDR3

<400>  7

Gln Gln Tyr Gln His Leu Pro Ile Thr 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am03/Ab2002.08Am06 LCDR3

<400>  8

Gln Gln Tyr Gln His Leu Pro Leu Thr 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am04/Ab2002.08Am05 LCDR3

<400>  9

Gln Gln Tyr Ala His Leu Pro Leu Thr 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.08 LCDR3

<400>  10

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3 ͨʽI

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaGln

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = IleLeu

<400>  11

Gln Gln Tyr Xaa His Leu Pro Xaa Thr 
1               5                   


<210>  12
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1 ͨʽI

<400>  12

Gly Gly Thr Phe Ser Ser Tyr 
1               5           


<210>  13
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am01 HCDR2

<400>  13

Ile Phe Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  14
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am02 HCDR2

<400>  14

Ile Phe Pro Ile Phe Gly Thr Ala Asn Val Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  15
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am03 HCDR2

<400>  15

Ile Phe Pro Val Phe Gly Thr Ala His Val Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  16
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am04 HCDR2

<400>  16

Ile Phe Pro Ala Phe Gly Thr Ala His His Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  17
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am05 HCDR2

<400>  17

Ile Phe Pro Met Phe Gly Thr Ala Asn Thr Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  18
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am06 HCDR2

<400>  18

Ile Phe Pro Val Phe Gly Thr Ala Asn Asn Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.08 HCDR2

<400>  19

Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  20
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2ͨʽI

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaIleMetVal

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = HisAsnThrValTyr

<400>  20

Ile Phe Pro Xaa Phe Gly Thr Ala Xaa Xaa Ala Gln Lys Phe Gln Gly 
1               5                   10                  15      


<210>  21
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am01/Ab2002.08Am03 HCDR3

<400>  21

Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Tyr Asp Ile 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am02/Ab2001.08 HCDR3

<400>  22

Leu Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ile 
1               5                   10                  


<210>  23
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am04/Ab2002.08Am06 HCDR3

<400>  23

Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ser 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am05 HCDR3

<400>  24

Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ile 
1               5                   10                  


<210>  25
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3ͨʽI

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = IleSer

<400>  25

Xaa Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Xaa Asp Xaa 
1               5                   10                  


<210>  26
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1ͨʽI

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  27
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2ͨʽI

<400>  27

Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  


<210>  28
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR3ͨʽI

<400>  28

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  29
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4ͨʽI

<400>  29

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  30
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽI

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  31
<211>  18
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽI

<400>  31

Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
1               5                   10                  15      


Gly Arg 
        


<210>  32
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽI

<400>  32

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  33
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR4ͨʽ

<400>  33

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  34
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am01 VL

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln His Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am02 VL

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Trp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln His Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  36
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am03 VL

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln Ala Ile Phe Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln His Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  37
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am04/Ab2002.08Am05 VL

<400>  37

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Phe Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala His Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  38
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am06 VL

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Phe Arg Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln His Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  39
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.08 VL

<400>  39

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  40
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLͨʽI

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = AlaSer

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = PheSerTrp

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa = AlaGln

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa = IleLeu

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Xaa Ser Gln Xaa Ile Xaa Xaa Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Xaa His Leu Pro Xaa 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am01 VH

<400>  41

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Tyr Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  42
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am02 VH

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Ile Phe Gly Thr Ala Asn Val Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  43
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am03 VH

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Val Phe Gly Thr Ala His Val Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Tyr Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  44
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am04 VH

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Ala Phe Gly Thr Ala His His Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am05 VH

<400>  45

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Met Phe Gly Thr Ala Asn Thr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  46
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.08Am06 VH

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Val Phe Gly Thr Ala Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Met Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  47
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.08 VH

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  48
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHͨʽI

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = AlaIleMetVal

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = HisAsn

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = HisAsnThrValTyr

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (110)..(110)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa = IleSer

<400>  48

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Phe Pro Xaa Phe Gly Thr Ala Xaa Xaa Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Xaa Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Xaa Asp Xaa 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  49
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am01 LCDR1

<400>  49

Arg Ala Ser Gln Ser Asp Leu Ser Ser Trp Leu Ala 
1               5                   10          


<210>  50
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am02 LCDR1

<400>  50

Arg Ala Ser Gln Ser Glu Leu Ser His Trp Leu Ala 
1               5                   10          


<210>  51
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am03 LCDR1

<400>  51

Arg Ala Ser Gln Ser Glu Leu Ser Ser Trp Leu Ala 
1               5                   10          


<210>  52
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am04/Ab2002.10Am05 LCDR1

<400>  52

Arg Ala Ser Gln Ser Gly Ile Ser Ser Trp Leu Ala 
1               5                   10          


<210>  53
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am06 LCDR1

<400>  53

Arg Ala Ser Gln Ser Gly Lys Ser Ser Trp Leu Ala 
1               5                   10          


<210>  54
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am07 LCDR1

<400>  54

Arg Ala Ser Gln Ser Gly Leu Ser Ser Trp Leu Ala 
1               5                   10          


<210>  55
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am08/Ab2002.10Am09 LCDR1

<400>  55

Arg Ala Ser Gln Ser Gly Thr Ser Ser Trp Leu Ala 
1               5                   10          


<210>  56
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am10 LCDR1

<400>  56

Arg Gly Ser Gln Ser Gly Leu Ser Ser Trp Leu Ala 
1               5                   10          


<210>  57
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.10 LCDR1

<400>  57

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  58
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1ͨʽII

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AspGluGly

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = IleLysLeuThr

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = HisSer

<400>  58

Arg Xaa Ser Gln Ser Xaa Xaa Ser Xaa Trp Leu Ala 
1               5                   10          


<210>  59
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2ͨʽII

<400>  59

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am01 LCDR3

<400>  60

Gln Gln Tyr Asp Thr Ser Pro Val Thr 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am02 LCDR3

<400>  61

Gln Gln Tyr Asp Arg Ser Pro Val Thr 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am03/Ab2002.10Am05/Ab2002.10Am07/Ab2002.10Am10/Ab2001.10 LCDR3

<400>  62

Gln Gln Tyr Asp Ser Ser Pro Ile Thr 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am04/Ab2002.10Am06/Ab2002.10Am08 LCDR3

<400>  63

Gln Gln Tyr Asp Ser Ser Pro Val Thr 
1               5                   


<210>  64
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am09 LCDR3

<400>  64

Gln Gln Tyr Asp Lys Ser Pro Val Thr 
1               5                   


<210>  65
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3ͨʽII

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = LysArgSerThr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = IleVal

<400>  65

Gln Gln Tyr Asp Xaa Ser Pro Xaa Thr 
1               5                   


<210>  66
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1ͨʽII

<400>  66

Gly Asp Thr Phe Ser Ser Phe 
1               5           


<210>  67
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am01 HCDR2

<400>  67

Trp Met His Ala Gly Ser Gly Met Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  68
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am02 HCDR2

<400>  68

Trp Met His Ala Gly Ser Gly Ile Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  69
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am03/Ab2002.10Am04/Ab2002.10Am09/Ab2002.10Am10 HCDR2

<400>  69

Trp Met His Ala Gly Ser Gly Leu Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am05 HCDR2

<400>  70

Trp Met His Ser Gly Ser Gly Ile Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am06 HCDR2

<400>  71

Trp Met His Ala Gly Ser Gly Leu Ala Gly Ser Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am07 HCDR2

<400>  72

Trp Met His Ser Gly Ser Gly Met Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am08 HCDR2

<400>  73

Trp Met His Val Gly Ser Gly Met Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  74
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.10 HCDR2

<400>  74

Trp Met His Ala Gly Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2ͨʽII

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AlaSerVal

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = IleLeuMet

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = SerTyr

<400>  75

Trp Met His Xaa Gly Ser Gly Xaa Ala Gly Xaa Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  76
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3ͨʽII

<400>  76

Tyr Val Pro His Gly Ala Phe Gln Ile 
1               5                   


<210>  77
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR1ͨʽII

<400>  77

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  78
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR2ͨʽII

<400>  78

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  79
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR3ͨʽII

<400>  79

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  80
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  L-FR4ͨʽII

<400>  80

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  81
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR1ͨʽII

<400>  81

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  82
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR2ͨʽII

<400>  82

Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  H-FR3ͨʽII

<400>  83

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asn 
            20                  25                  30          


<210>  84
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am01 VL

<400>  84

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Asp Leu Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Thr Ser Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  85
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am02 VL

<400>  85

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Glu Leu Ser His 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Arg Ser Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  86
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am03 VL

<400>  86

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Glu Leu Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  87
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am04 VL

<400>  87

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Ile Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  88
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am05 VL

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Ile Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  89
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am06 VL

<400>  89

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Lys Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  90
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am07 VL

<400>  90

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Leu Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  91
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am08 VL

<400>  91

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Thr Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  92
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am09 VL

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Gly Thr Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Lys Ser Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  93
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am10 VL

<400>  93

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Gly Ser Gln Ser Gly Leu Ser Ser 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  94
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.10 VL

<400>  94

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  95
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VLͨʽII

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = AlaGly

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = AspGluGly

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = IleLysLeuThr

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = HisSer

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa = LysArgSerThr

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = IleVal

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Xaa Ser Gln Ser Xaa Xaa Ser Xaa 
            20                  25                  30          


Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Xaa Ser Pro 
                85                  90                  95      


Xaa Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  96
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am01 VH

<400>  96

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ala Gly Ser Gly Met Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  97
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am02 VH

<400>  97

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ala Gly Ser Gly Ile Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  98
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am03/Ab2002.10Am04/Ab2002.10Am09/Ab2002.10Am10 VH

<400>  98

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ala Gly Ser Gly Leu Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  99
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am05 VH

<400>  99

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ser Gly Ser Gly Ile Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  100
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am06 VH

<400>  100

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ala Gly Ser Gly Leu Ala Gly Ser Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  101
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am07 VH

<400>  101

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ser Gly Ser Gly Met Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  102
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2002.10Am08 VH

<400>  102

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Val Gly Ser Gly Met Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  103
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.10 VH

<400>  103

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ala Gly Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  104
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VHͨʽII

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa = AlaSerVal

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = IleLeuMet

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = SerTyr

<400>  104

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Xaa Gly Ser Gly Xaa Ala Gly Xaa Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             



