                         SEQUENCE LISTING

<110>  NOVARTIS AG
 
<120>  DOSING REGIMEN FOR COMBINATION THERAPIES WITH MULTISPECIFIC 
       ANTIBODIES TARGETING B-CELL MATURATION ANTIGEN AND GAMMA
       SECRETASE INHIBITORS

<130>  PAT058995-WO-PCT

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Thr Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Gly Ser Gly Tyr Ala Leu His Asp Asp Tyr Tyr Gly Leu Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asp Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
225                 230                 235                 240 


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Lys 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Glu Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Asp Val Ser Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asp Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Glu Gln Gly Asp Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  2
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Leu Arg Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Ala Leu Tyr Val Phe Gly Ser Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
    130                 135                 140                 


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
145                 150                 155                 160 


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
                165                 170                 175     


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
            180                 185                 190         


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
        195                 200                 205             


Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215         


<210>  3
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Arg Ser Lys Ala Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Arg His Gly Asn Phe Gly Asp Ser Tyr Val Ser Trp Phe 
            100                 105                 110         


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Lys Pro 
        115                 120                 125             


Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly 
    130                 135                 140                 


Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
145                 150                 155                 160 


Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Thr 
                165                 170                 175     


Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Lys Ser Pro Arg 
            180                 185                 190         


Gly Leu Ile Gly Gly Thr Asn Lys Arg Ala Pro Gly Val Pro Ala Arg 
        195                 200                 205             


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Ile Ser Gly 
    210                 215                 220                 


Ala Gln Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser 
225                 230                 235                 240 


Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Glu Pro 
                245                 250                 255     


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro 
            260                 265                 270         


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        275                 280                 285             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    290                 295                 300                 


Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
305                 310                 315                 320 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                325                 330                 335     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            340                 345                 350         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        355                 360                 365             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    370                 375                 380                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Gln Met Thr Lys Asn Gln 
385                 390                 395                 400 


Val Lys Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                405                 410                 415     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            420                 425                 430         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        435                 440                 445             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    450                 455                 460                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
465                 470                 475                 480 


Leu Ser Pro Gly Lys 
                485 


<210>  4
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
caagtgcagc tcgtggagtc tggaggggga gtcgtgcagc ctggacgctc cctgagactg       60

tcctgtgcgg cttcgggatt cactgtgtcc agctacggca tgcattgggt ccgccaagca      120

ccgggaaaag gcctggagtg ggtggccgtg atctcctaca ccggctcaaa caagtactac      180

gccgacagcg tgaagggccg gttcaccatt tcaagggaca actccaagaa taccctgtat      240

ctgcaaatga actcgctgcg ggcagaggac accgccgtgt actactgcgg tggctccggt      300

tacgccctgc acgatgacta ctacgggctc gatgtctggg gacaggggac gctcgtgact      360

gtgtcctcgg ctagcaccaa gggcccgtca gtgtttcctc tggccccaag ctccaagtcc      420

acctccggtg gtacagccgc gttgggatgc ttggtcaagg actactttcc ggaacccgtg      480

accgtgtcct ggaactccgg cgccctgact agcggagtgc acaccttccc cgctgtgctg      540

cagtctagcg ggctgtattc cctctcgtcc gtggtcaccg tgccgtcctc atccctggga      600

acccagacct acatttgcaa cgtgaaccac aagccgtcag acaccaaggt ggacaagaag      660

gtggagccga agtcctgcga caagacccat acttgtcctc cttgccccgc tccacctgtg      720

gcgggacctt ccgtgttcct tttcccgccg aagccgaagg acactctgat gatctcgcgg      780

actcccgaag tcacttgcgt ggtggtggac gtcaaacacg aagatcccga ggtcaagttc      840

aattggtacg tggacggggt ggaagtccac aacgccaaga ctaagccgcg cgaggaagag      900

tacaattcca cttaccgggt cgtgtcggtg ctgactgtgc tgcatcagga ctggctgaac      960

ggaaaggagt acaagtgcaa agtgtcgaac aaggccctgc ctgcaccaat cgaaaagacc     1020

attagcaaag ccaagggcca gccgagagaa ccccaagtct acactctgcc accatcccgc     1080

gaagaaatga ccaagaacca agtgtcgctg acgtgcgacg tgtcgggatt ctacccgtcc     1140

gatattgccg tggaatggga gagcgacggc caacccgaga acaactacaa gactaccccc     1200

cccgtcttgg attccgatgg ttccttcttc ctgtactcca agctgaccgt ggataagtcc     1260

cgatgggagc agggcgatgt gttctcgtgc tccgtgatgc atgaagccct gcacaaccac     1320

tatacccaga agtcactgtc gctgagccct gggaag                               1356


<210>  5
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
cagtcggcgc tgactcagcc cgcatccgtg agcggttcac cgggacagag catcaccatt       60

tcctgcaccg gaacctcaag cgacgtgggc ggctacaact acgtgtcctg gtatcagcag      120

cacccgggaa aggccccaaa gctcatgatc tacgacgtgt ccaatagact gcggggagtg      180

tccaaccggt tctcgggaag caaatccggc aacactgctt ccctgaccat cagcggactc      240

caggccgaag atgaggccga ctactactgc tcatcctaca cgtcctcttc ggcgctttac      300

gtgttcgggt cggggaccaa ggtcaccgtc ctgggccaac ctaaggcggc gccctcagtg      360

accctgttcc ctccgtcgtc tgaagaactc caggccaaca aggccaccct cgtgtgcctg      420

atttcggact tctacccggg agccgtcact gtggcctgga aggccgacag cagcccagtg      480

aaggccggcg tggaaactac caccccgtcc aagcagtcca acaataagta cgcagccagc      540

tcctacctgt ccctgacccc cgaacaatgg aagtcacaca gatcctactc ctgtcaagtc      600

acccacgagg gcagcactgt cgaaaagacc gtggcaccga ctgagtgctc g               651


<210>  6
<211>  1455
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
gaagtgcagc ttgtggagtc cgggggagga ttggtccaac ccggtggctc gctgaggctg       60

agttgcgccg cttcggggtt taccttcagc acctacgcta tgaactgggt cagacaggcg      120

cctggaaagg gtttggagtg ggtcggacgc atccggtcca aggccaacaa ctacgcgact      180

tactatgccg actccgtcaa gggacggttc accatctccc gggacgacag caagaacacc      240

ctgtacctcc aaatgaactc ccttcgggcc gaagataccg ccgtgtacta ctgcgtgaga      300

cacggcaact tcggcgactc ctacgtgtcc tggtttgcct actggggcca gggtactctc      360

gtgaccgtgt catcaggaaa gccaggctcg gggaagcctg gctccggaaa gcctgggagc      420

ggaaagccgg gatcgcaggc tgtggtcacc caggaaccct ccctgactgt gtccccggga      480

ggaaccgtga cactgacttg tggcagctcc accggagccg tgaccacctc caactacgcc      540

aactgggtgc agcaaaagcc aggaaagtcc cctagggggc tgatcggtgg cacgaacaag      600

cgggcacctg gagtgcctgc ccgattctcg ggtagcctgc tggggggaaa agccgccctg      660

accatttcgg gcgctcagcc agaggacgaa gccgactatt actgcgcact ctggtactcc      720

aaccactggg tgttcggtgg aggcaccaag ctgaccgtgc tggagccaaa gtcaagcgac      780

aaaactcaca cttgccctcc ttgtccggct cctcctgtgg ctggtccctc cgtgttcctc      840

ttcccgccga agccgaagga caccctcatg atttcccgga cgcccgaagt cacttgtgtg      900

gtggtcgatg tgaagcatga ggaccccgaa gtgaagttca attggtacgt ggatggcgtg      960

gaggtccaca acgccaagac caagccgcgc gaagaacagt acaacagcac ctaccgcgtc     1020

gtgagcgtgc tcaccgtgct ccaccaagat tggctgaacg gaaaggagta caagtgcaaa     1080

gtgtccaaca aggcccttcc tgcacctatt gaaaagacta ttagcaaggc caagggacag     1140

ccccgcgaac ctcaagtgta cactctgccg ccgtccagag agcagatgac caaaaaccag     1200

gtcaagctca cttgtctcgt gaagggcttc tacccgtccg atatcgcggt cgaatgggag     1260

tcaaacggcc agcccgagaa caactacaag actaccccac cggtgcttga ctccgacggt     1320

tcgttctttc tgtactccaa gctgaccgtg gacaagtccc ggtggcagca agggaatgtg     1380

ttcagctgct ccgtgatgca cgaagccctg cataaccact acacccagaa gtcgctcagc     1440

ctgtcccctg gaaaa                                                      1455


