                         SEQUENCE LISTING

<110>  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
 
<120>  ENGINEERED T CELL RECEPTORS TARGETING EGFR ANTIGENS AND METHODS 
       OF USE

<130>  MDAC.P1246WO

<150>  63/110,136
<151>  2020-11-05

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  1827
<212>  DNA
<213>  Homo Sapiens

<400>  1
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcaa agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgacgagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtat ttctgtgcaa tgaacacagg ctttcagaaa      360

cttgtatttg gaactggcac ccgacttctg gtcagtccaa atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaat      540

gctgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gccgtgccaa gcgaagcgga      840

tctggcgcca cgaacttctc tctgttaaag caagcaggag atgttgaaga aaaccccggg      900

cctatgggct cctggaccct ctgctgtgtg tccctttgca tcctggtagc aaagcacaca      960

gatgctggag ttatccagtc accccggcac gaggtgacag agatgggaca agaagtgact     1020

ctgagatgta aaccaatttc aggacacgac taccttttct ggtacagaca gaccatgatg     1080

cggggactgg agttgctcat ttactttaac aacaacgttc cgatagatga ttcagggatg     1140

cccgaggatc gattctcagc taagatgcct aatgcatcat tctccactct gaagatccag     1200

ccctcagaac ccagggactc agctgtgtac ttctgtgcca gcagaaacgg gcctgaagct     1260

ttctttggac aaggcaccag actcacagtt gtagaggacc tgaacaaggt gttcccaccc     1320

gaggtcgctg tgtttgagcc atcagaagca gagatctccc acacccaaaa ggccacactg     1380

gtgtgcctgg ccacaggctt cttccctgac cacgtggagc tgagctggtg ggtgaatggg     1440

aaggaggtgc acagtggggt ctgcacggac ccgcagcccc tcaaggagca gcccgccctc     1500

aatgactcca gatactgcct gagcagccgc ctgagggtct cggccacctt ctggcagaac     1560

ccccgcaacc acttccgctg tcaagtccag ttctacgggc tctcggagaa tgacgagtgg     1620

acccaggata gggccaaacc cgtcacccag atcgtcagcg ccgaggcctg gggtagagca     1680

gactgtggct ttacctcggt gtcctaccag caaggggtcc tgtctgccac catcctctat     1740

gagatcctgc tagggaaggc caccctgtat gctgtgctgg tcagcgccct tgtgttgatg     1800

gccatggtca agagaaagga tttctga                                         1827


<210>  2
<211>  608
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Asn Thr Gly Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg 
        115                 120                 125             


Leu Leu Val Ser Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Asn Ala Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
        275                 280                 285             


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Ser 
    290                 295                 300                 


Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys His Thr 
305                 310                 315                 320 


Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
                325                 330                 335     


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asp Tyr Leu 
            340                 345                 350         


Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr 
        355                 360                 365             


Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
    370                 375                 380                 


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
385                 390                 395                 400 


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Asn 
                405                 410                 415     


Gly Pro Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu 
            420                 425                 430         


Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
        435                 440                 445             


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
    450                 455                 460                 


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
465                 470                 475                 480 


Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu 
                485                 490                 495     


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
            500                 505                 510         


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
        515                 520                 525             


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
    530                 535                 540                 


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
545                 550                 555                 560 


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
                565                 570                 575     


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
            580                 585                 590         


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
        595                 600                 605             


<210>  3
<211>  280
<212>  PRT
<213>  Homo Sapiens

<400>  3

Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys Glu 
1               5                   10                  15      


Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr Gly 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu Ile 
        35                  40                  45              


Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr Ser 
    50                  55                  60                  


Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser Ala 
65                  70                  75                  80  


Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Asn Thr Gly 
                85                  90                  95      


Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu Leu Val Ser Pro 
            100                 105                 110         


Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys 
        115                 120                 125             


Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr 
    130                 135                 140                 


Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Asn Ala 
145                 150                 155                 160 


Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala 
                165                 170                 175     


Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser 
            180                 185                 190         


Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp 
        195                 200                 205             


Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe 
    210                 215                 220                 


Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala 
225                 230                 235                 240 


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys 
                245                 250                 255     


Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
            260                 265                 270         


Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280 


<210>  4
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  4

Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys Glu 
1               5                   10                  15      


Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr Gly 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu Ile 
        35                  40                  45              


Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr Ser 
    50                  55                  60                  


Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser Ala 
65                  70                  75                  80  


Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Asn Thr Gly 
                85                  90                  95      


Phe Gln Lys Leu Val Phe Gly Thr Gly Thr Arg Leu Leu Val Ser Pro 
            100                 105                 110         


<210>  5
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala 
            20      


<210>  6
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  6

Thr Ser Asp Gln Ser Tyr Gly 
1               5           


<210>  7
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  7

Gln Gly Ser Tyr Asp Glu Gln Asn 
1               5               


<210>  8
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  8

Ala Met Asn Thr Gly Phe Gln Lys Leu Val 
1               5                   10  


<210>  9
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  9

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asp Tyr Leu Phe Trp 
            20                  25                  30          


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        35                  40                  45              


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Asn Gly Pro 
                85                  90                  95      


Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu 
            100                 105                 110         


Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
        115                 120                 125             


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
    130                 135                 140                 


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
145                 150                 155                 160 


Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
                165                 170                 175     


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            180                 185                 190         


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        195                 200                 205             


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
    210                 215                 220                 


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
225                 230                 235                 240 


Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                245                 250                 255     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            260                 265                 270         


Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
        275                 280                 285     


<210>  10
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  10

Asp Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly 
1               5                   10                  15      


Gln Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asp Tyr Leu 
            20                  25                  30          


Phe Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr 
        35                  40                  45              


Phe Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg 
    50                  55                  60                  


Phe Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln 
65                  70                  75                  80  


Pro Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Asn 
                85                  90                  95      


Gly Pro Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
            100                 105                 110     


<210>  11
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala 
            20      


<210>  12
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  12

Ser Gly His Asp Tyr 
1               5   


<210>  13
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  13

Phe Asn Asn Asn Val Pro 
1               5       


<210>  14
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  14

Ala Ser Arg Asn Gly Pro Glu Ala Phe 
1               5                   


<210>  15
<211>  1866
<212>  DNA
<213>  Homo Sapiens

<400>  15
atgaacatgc tgactgcccg cctgttgagg gcagtcatag cctccatctg tgttgtatcc       60

agcatggctc agaaggtaac tcaagcgcag actgaaattt ctgtggtgga gaaggaggat      120

gtgaccttgg actgtgtgta tgaaacccgt gatactactt attacttatt ctggtacaag      180

caaccaccaa gtggagaatt ggttttcctt attcgtcgga actcttttga tgagcaaaat      240

gaaataagtg gtcggtattc ttggaacttc cagaaatcca ccagttcctt caacttcacc      300

atcacagcct cacaagtcgt ggactcagca gtatacttct gtgccttggg ggcgggaggg      360

gctagcaaca caggcaaact aatctttggg caagggacaa ctttacaagt aaaaccagat      420

atccagaacc ctgaccctgc cgtgtaccag ctgagagact ctaaatccag tgacaagtct      480

gtctgcctat tcaccgattt tgattctcaa acaaatgtgt cacaaagtaa ggattctgat      540

gtgtatatca cagacaatgc tgtgctagac atgaggtcta tggacttcaa gagcaacagt      600

gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa caacagcatt      660

attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa gctggtcgag      720

aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga      780

atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc      840

cgtgccaagc gaagcggatc tggcgccacg aacttctctc tgttaaagca agcaggagat      900

gttgaagaaa accccgggcc tatgggcacc agcctcctct gctggatggc cctgtgtctc      960

ctgggggcag atcacgcaga tactggagtc tcccaggacc ccagacacaa gatcacaaag     1020

aggggacaga atgtaacttt caggtgtgat ccaatttctg aacacaaccg cctttattgg     1080

taccgacaga ccctggggca gggcccagag tttctgactt acttccagaa tgaagctcaa     1140

ctagaaaaat caaggctgct cagtgatcgg ttctctgcag agaggcctaa gggatctttc     1200

tccaccttgg agatccagcg cacagagcag ggggactcgg ccatgtatct ctgtgccagc     1260

agcttagcga caggactttc ggggttagtt gaaaaactgt tttttggcag tggaacccag     1320

ctctctgtct tggaggacct gaacaaggtg ttcccacccg aggtcgctgt gtttgagcca     1380

tcagaagcag agatctccca cacccaaaag gccacactgg tgtgcctggc cacaggcttc     1440

ttccctgacc acgtggagct gagctggtgg gtgaatggga aggaggtgca cagtggggtc     1500

tgcacggacc cgcagcccct caaggagcag cccgccctca atgactccag atactgcctg     1560

agcagccgcc tgagggtctc ggccaccttc tggcagaacc cccgcaacca cttccgctgt     1620

caagtccagt tctacgggct ctcggagaat gacgagtgga cccaggatag ggccaaaccc     1680

gtcacccaga tcgtcagcgc cgaggcctgg ggtagagcag actgtggctt tacctcggtg     1740

tcctaccagc aaggggtcct gtctgccacc atcctctatg agatcctgct agggaaggcc     1800

accctgtatg ctgtgctggt cagcgccctt gtgttgatgg ccatggtcaa gagaaaggat     1860

ttctga                                                                1866


<210>  16
<211>  621
<212>  PRT
<213>  Homo Sapiens

<400>  16

Met Asn Met Leu Thr Ala Arg Leu Leu Arg Ala Val Ile Ala Ser Ile 
1               5                   10                  15      


Cys Val Val Ser Ser Met Ala Gln Lys Val Thr Gln Ala Gln Thr Glu 
            20                  25                  30          


Ile Ser Val Val Glu Lys Glu Asp Val Thr Leu Asp Cys Val Tyr Glu 
        35                  40                  45              


Thr Arg Asp Thr Thr Tyr Tyr Leu Phe Trp Tyr Lys Gln Pro Pro Ser 
    50                  55                  60                  


Gly Glu Leu Val Phe Leu Ile Arg Arg Asn Ser Phe Asp Glu Gln Asn 
65                  70                  75                  80  


Glu Ile Ser Gly Arg Tyr Ser Trp Asn Phe Gln Lys Ser Thr Ser Ser 
                85                  90                  95      


Phe Asn Phe Thr Ile Thr Ala Ser Gln Val Val Asp Ser Ala Val Tyr 
            100                 105                 110         


Phe Cys Ala Leu Gly Ala Gly Gly Ala Ser Asn Thr Gly Lys Leu Ile 
        115                 120                 125             


Phe Gly Gln Gly Thr Thr Leu Gln Val Lys Pro Asp Ile Gln Asn Pro 
    130                 135                 140                 


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
145                 150                 155                 160 


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
                165                 170                 175     


Lys Asp Ser Asp Val Tyr Ile Thr Asp Asn Ala Val Leu Asp Met Arg 
            180                 185                 190         


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
        195                 200                 205             


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
    210                 215                 220                 


Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu 
225                 230                 235                 240 


Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val 
                245                 250                 255     


Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
            260                 265                 270         


Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly 
        275                 280                 285             


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
    290                 295                 300                 


Pro Gly Pro Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu 
305                 310                 315                 320 


Leu Gly Ala Asp His Ala Asp Thr Gly Val Ser Gln Asp Pro Arg His 
                325                 330                 335     


Lys Ile Thr Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile 
            340                 345                 350         


Ser Glu His Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly 
        355                 360                 365             


Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser 
    370                 375                 380                 


Arg Leu Leu Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe 
385                 390                 395                 400 


Ser Thr Leu Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr 
                405                 410                 415     


Leu Cys Ala Ser Ser Leu Ala Thr Gly Leu Ser Gly Leu Val Glu Lys 
            420                 425                 430         


Leu Phe Phe Gly Ser Gly Thr Gln Leu Ser Val Leu Glu Asp Leu Asn 
        435                 440                 445             


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
    450                 455                 460                 


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
465                 470                 475                 480 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
                485                 490                 495     


His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
            500                 505                 510         


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
        515                 520                 525             


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
    530                 535                 540                 


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
545                 550                 555                 560 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
                565                 570                 575     


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
            580                 585                 590         


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
        595                 600                 605             


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
    610                 615                 620     


<210>  17
<211>  284
<212>  PRT
<213>  Homo Sapiens

<400>  17

Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser Val Val Glu Lys Glu 
1               5                   10                  15      


Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg Asp Thr Thr Tyr Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu Leu Val Phe Leu Ile 
        35                  40                  45              


Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile Ser Gly Arg Tyr Ser 
    50                  55                  60                  


Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn Phe Thr Ile Thr Ala 
65                  70                  75                  80  


Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys Ala Leu Gly Ala Gly 
                85                  90                  95      


Gly Ala Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Gln Val Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
        115                 120                 125             


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
    130                 135                 140                 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
145                 150                 155                 160 


Thr Asp Asn Ala Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
                165                 170                 175     


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
            180                 185                 190         


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
        195                 200                 205             


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
    210                 215                 220                 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
225                 230                 235                 240 


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
                245                 250                 255     


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
            260                 265                 270         


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280                 


<210>  18
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  18

Gln Lys Val Thr Gln Ala Gln Thr Glu Ile Ser Val Val Glu Lys Glu 
1               5                   10                  15      


Asp Val Thr Leu Asp Cys Val Tyr Glu Thr Arg Asp Thr Thr Tyr Tyr 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Pro Ser Gly Glu Leu Val Phe Leu Ile 
        35                  40                  45              


Arg Arg Asn Ser Phe Asp Glu Gln Asn Glu Ile Ser Gly Arg Tyr Ser 
    50                  55                  60                  


Trp Asn Phe Gln Lys Ser Thr Ser Ser Phe Asn Phe Thr Ile Thr Ala 
65                  70                  75                  80  


Ser Gln Val Val Asp Ser Ala Val Tyr Phe Cys Ala Leu Gly Ala Gly 
                85                  90                  95      


Gly Ala Ser Asn Thr Gly Lys Leu Ile Phe Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Gln Val Lys Pro 
        115     


<210>  19
<211>  23
<212>  PRT
<213>  Homo Sapiens

<400>  19

Met Asn Met Leu Thr Ala Arg Leu Leu Arg Ala Val Ile Ala Ser Ile 
1               5                   10                  15      


Cys Val Val Ser Ser Met Ala 
            20              


<210>  20
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  20

Thr Arg Asp Thr Thr Tyr Tyr 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  21

Arg Asn Ser Phe Asp Glu Gln Asn 
1               5               


<210>  22
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  22

Ala Leu Gly Ala Gly Gly Ala Ser Asn Thr Gly Lys Leu Ile 
1               5                   10                  


<210>  23
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  23

Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly Gln Asn 
1               5                   10                  15      


Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln 
        35                  40                  45              


Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln Arg Thr 
65                  70                  75                  80  


Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Leu Ala Thr 
                85                  90                  95      


Gly Leu Ser Gly Leu Val Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
            100                 105                 110         


Leu Ser Val Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala 
        115                 120                 125             


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
    130                 135                 140                 


Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser 
145                 150                 155                 160 


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
                165                 170                 175     


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
            180                 185                 190         


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
        195                 200                 205             


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
    210                 215                 220                 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
225                 230                 235                 240 


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln 
                245                 250                 255     


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
            260                 265                 270         


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
        275                 280                 285             


Lys Arg Lys Asp Phe 
    290             


<210>  24
<211>  116
<212>  PRT
<213>  Homo Sapiens

<400>  24

Gly Val Ser Gln Asp Pro Arg His Lys Ile Thr Lys Arg Gly Gln Asn 
1               5                   10                  15      


Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu Tyr Trp 
            20                  25                  30          


Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln 
        35                  40                  45              


Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg Phe Ser 
    50                  55                  60                  


Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln Arg Thr 
65                  70                  75                  80  


Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Leu Ala Thr 
                85                  90                  95      


Gly Leu Ser Gly Leu Val Glu Lys Leu Phe Phe Gly Ser Gly Thr Gln 
            100                 105                 110         


Leu Ser Val Leu 
        115     


<210>  25
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr 
            20      


<210>  26
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  26

Ser Glu His Asn Arg 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  27

Phe Gln Asn Glu Ala Gln 
1               5       


<210>  28
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  28

Ala Ser Ser Leu Ala Thr Gly Leu Ser Gly Leu Val Glu Lys Leu Phe 
1               5                   10                  15      


<210>  29
<211>  1824
<212>  DNA
<213>  Homo Sapiens

<400>  29
atgatgatat ccttgagagt tttactggtg atcctgtggc ttcagttaag ctgggtttgg       60

agccaacgga aggaggtgga gcaggatcct ggacccttca atgttccaga gggagccact      120

gtcgctttca actgtactta cagcaacagt gcttctcagt ctttcttctg gtacagacag      180

gattgcagga aagaacctaa gttgctgatg tccgtatact ccagtggtaa tgaagatgga      240

aggtttacag cacagctcaa tagagccagc cagtatattt ccctgctcat cagagactcc      300

aagctcagtg attcagccac ctacctctgt gtggtgatag gaggaggtgc tgacggactc      360

acctttggca aagggactca tctaatcatc cagccctata tccagaaccc tgaccctgcc      420

gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt      480

gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaatgct      540

gtgctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa      600

tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc      660

cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg      720

aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc      780

gggtttaatc tgctcatgac gctgcggctg tggtccagcc gtgccaagcg aagcggatct      840

ggcgccacga acttctctct gttaaagcaa gcaggagatg ttgaagaaaa ccccgggcct      900

atgggctcct ggaccctctg ctgtgtgtcc ctttgcatcc tggtagcaaa gcacacagat      960

gctggagtta tccagtcacc ccggcacgag gtgacagaga tgggacaaga agtgactctg     1020

agatgtaaac caatttcagg acacgactac cttttctggt acagacagac catgatgcgg     1080

ggactggagt tgctcattta ctttaacaac aacgttccga tagatgattc agggatgccc     1140

gaggatcgat tctcagctaa gatgcctaat gcatcattct ccactctgaa gatccagccc     1200

tcagaaccca gggactcagc tgtgtacttc tgtgccagca gaaacgggcc tgaagctttc     1260

tttggacaag gcaccagact cacagttgta gaggacctga acaaggtgtt cccacccgag     1320

gtcgctgtgt ttgagccatc agaagcagag atctcccaca cccaaaaggc cacactggtg     1380

tgcctggcca caggcttctt ccctgaccac gtggagctga gctggtgggt gaatgggaag     1440

gaggtgcaca gtggggtctg cacggacccg cagcccctca aggagcagcc cgccctcaat     1500

gactccagat actgcctgag cagccgcctg agggtctcgg ccaccttctg gcagaacccc     1560

cgcaaccact tccgctgtca agtccagttc tacgggctct cggagaatga cgagtggacc     1620

caggataggg ccaaacccgt cacccagatc gtcagcgccg aggcctgggg tagagcagac     1680

tgtggcttta cctcggtgtc ctaccagcaa ggggtcctgt ctgccaccat cctctatgag     1740

atcctgctag ggaaggccac cctgtatgct gtgctggtca gcgcccttgt gttgatggcc     1800

atggtcaaga gaaaggattt ctga                                            1824


<210>  30
<211>  607
<212>  PRT
<213>  Homo Sapiens

<400>  30

Met Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Phe Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys 
    50                  55                  60                  


Glu Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val 
            100                 105                 110         


Ile Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu 
        115                 120                 125             


Ile Ile Gln Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Asn Ala Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Ser Trp 
    290                 295                 300                 


Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys His Thr Asp 
305                 310                 315                 320 


Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln 
                325                 330                 335     


Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asp Tyr Leu Phe 
            340                 345                 350         


Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe 
        355                 360                 365             


Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe 
    370                 375                 380                 


Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro 
385                 390                 395                 400 


Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Asn Gly 
                405                 410                 415     


Pro Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp 
            420                 425                 430         


Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
        435                 440                 445             


Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
    450                 455                 460                 


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
465                 470                 475                 480 


Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln 
                485                 490                 495     


Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            500                 505                 510         


Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        515                 520                 525             


Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala 
    530                 535                 540                 


Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp 
545                 550                 555                 560 


Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                565                 570                 575     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            580                 585                 590         


Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
        595                 600                 605         


<210>  31
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  31

Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val Pro Glu 
1               5                   10                  15      


Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp Ser Lys 
65                  70                  75                  80  


Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Ile Gly Gly Gly Ala 
                85                  90                  95      


Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro Tyr 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Asn Ala Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
        195                 200                 205             


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
    210                 215                 220                 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
225                 230                 235                 240 


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
                245                 250                 255     


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            260                 265                 270         


Val Glu Glu Asn Pro Gly Pro 
        275                 


<210>  32
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  32

Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val Pro Glu 
1               5                   10                  15      


Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp Ser Lys 
65                  70                  75                  80  


Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Ile Gly Gly Gly Ala 
                85                  90                  95      


Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro 
            100                 105                 110     


<210>  33
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  33

Met Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser 
            20      


<210>  34
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  34

Asn Ser Ala Ser Gln Ser 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  35

Val Tyr Ser Ser Gly Asn 
1               5       


<210>  36
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  36

Val Val Ile Gly Gly Gly Ala Asp Gly Leu Thr 
1               5                   10      


<210>  37
<211>  286
<212>  PRT
<213>  Homo Sapiens

<400>  37

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asp Tyr Leu Phe Trp 
            20                  25                  30          


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        35                  40                  45              


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Asn Gly Pro 
                85                  90                  95      


Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu 
            100                 105                 110         


Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
        115                 120                 125             


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
    130                 135                 140                 


Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
145                 150                 155                 160 


Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
                165                 170                 175     


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            180                 185                 190         


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        195                 200                 205             


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
    210                 215                 220                 


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
225                 230                 235                 240 


Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                245                 250                 255     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            260                 265                 270         


Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
        275                 280                 285     


<210>  38
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  38

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asp Tyr Leu Phe Trp 
            20                  25                  30          


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        35                  40                  45              


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Asn Gly Pro 
                85                  90                  95      


Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
            100                 105                 


<210>  39
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  39

Met Gly Ser Trp Thr Leu Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala 
            20      


<210>  40
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  40

Ser Gly His Asp Tyr 
1               5   


<210>  41
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  41

Phe Asn Asn Asn Val Pro 
1               5       


<210>  42
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  42

Ala Ser Arg Asn Gly Pro Glu Ala Phe 
1               5                   


<210>  43
<211>  1905
<212>  DNA
<213>  Homo Sapiens

<400>  43
atgatgatat ccttgagagt tttactggtg atcctgtggc ttcagttaag ctgggtttgg       60

agccaacgga aggaggtgga gcaggatcct ggacccttca atgttccaga gggagccact      120

gtcgctttca actgtactta cagcaacagt gcttctcagt ctttcttctg gtacagacag      180

gattgcagga aagaacctaa gttgctgatg tccgtatact ccagtggtaa tgaagatgga      240

aggtttacag cacagctcaa tagagccagc cagtatattt ccctgctcat cagagactcc      300

aagctcagtg attcagccac ctacctctgt gtggtgatag gaggaggtgc tgacggactc      360

acctttggca aagggactca tctaatcatc cagccctata tccagaaccc tgaccctgcc      420

gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt      480

gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaatgct      540

gtgctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa      600

tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc      660

cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg      720

aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc      780

gggtttaatc tgctcatgac gctgcggctg tggtccagcc gtgccaagcg aagcggatct      840

ggcgccacga acttctctct gttaaagcaa gcaggagatg ttgaagaaaa ccccgggcct      900

atggggagaa ttcactcggc tcttccccag gaggaccaag ccctgaatca ggtgcagtgc      960

tgcctgcccc actgtgccat gggccctggg ctcctctgct gggcgctgct ttgtctcctg     1020

ggagcaggct cagtggagac tggagtcacc caaagtccca cacacctgat caaaacgaga     1080

ggacagcaag tgactctgag atgctcttct cagtctgggc acaacactgt gtcctggtac     1140

caacaggccc tgggtcaggg gccccagttt atctttcagt attataggga ggaagagaat     1200

ggcagaggaa acttccctcc tagattctca ggtctccagt tccctaatta tagctctgag     1260

ctgaatgtga acgccttgga gctggacgac tcggccctgt atctctgtgc cagcagcgtg     1320

gggggggaca ctgaagcttt ctttggacaa ggcaccagac tcacagttgt agaggacctg     1380

aacaaggtgt tcccacccga ggtcgctgtg tttgagccat cagaagcaga gatctcccac     1440

acccaaaagg ccacactggt gtgcctggcc acaggcttct tccctgacca cgtggagctg     1500

agctggtggg tgaatgggaa ggaggtgcac agtggggtct gcacggaccc gcagcccctc     1560

aaggagcagc ccgccctcaa tgactccaga tactgcctga gcagccgcct gagggtctcg     1620

gccaccttct ggcagaaccc ccgcaaccac ttccgctgtc aagtccagtt ctacgggctc     1680

tcggagaatg acgagtggac ccaggatagg gccaaacccg tcacccagat cgtcagcgcc     1740

gaggcctggg gtagagcaga ctgtggcttt acctcggtgt cctaccagca aggggtcctg     1800

tctgccacca tcctctatga gatcctgcta gggaaggcca ccctgtatgc tgtgctggtc     1860

agcgcccttg tgttgatggc catggtcaag agaaaggatt tctga                     1905


<210>  44
<211>  634
<212>  PRT
<213>  Homo Sapiens

<400>  44

Met Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Phe Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys 
    50                  55                  60                  


Glu Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val 
            100                 105                 110         


Ile Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu 
        115                 120                 125             


Ile Ile Gln Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Asn Ala Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg Ile 
    290                 295                 300                 


His Ser Ala Leu Pro Gln Glu Asp Gln Ala Leu Asn Gln Val Gln Cys 
305                 310                 315                 320 


Cys Leu Pro His Cys Ala Met Gly Pro Gly Leu Leu Cys Trp Ala Leu 
                325                 330                 335     


Leu Cys Leu Leu Gly Ala Gly Ser Val Glu Thr Gly Val Thr Gln Ser 
            340                 345                 350         


Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln Val Thr Leu Arg Cys 
        355                 360                 365             


Ser Ser Gln Ser Gly His Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu 
    370                 375                 380                 


Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn 
385                 390                 395                 400 


Gly Arg Gly Asn Phe Pro Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn 
                405                 410                 415     


Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Glu Leu Asp Asp Ser Ala 
            420                 425                 430         


Leu Tyr Leu Cys Ala Ser Ser Val Gly Gly Asp Thr Glu Ala Phe Phe 
        435                 440                 445             


Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp Leu Asn Lys Val Phe 
    450                 455                 460                 


Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His 
465                 470                 475                 480 


Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp 
                485                 490                 495     


His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly 
            500                 505                 510         


Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp 
        515                 520                 525             


Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp 
    530                 535                 540                 


Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu 
545                 550                 555                 560 


Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln 
                565                 570                 575     


Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser 
            580                 585                 590         


Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile 
        595                 600                 605             


Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val 
    610                 615                 620                 


Leu Met Ala Met Val Lys Arg Lys Asp Phe 
625                 630                 


<210>  45
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  45

Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val Pro Glu 
1               5                   10                  15      


Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp Ser Lys 
65                  70                  75                  80  


Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Ile Gly Gly Gly Ala 
                85                  90                  95      


Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro Tyr 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Asn Ala Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
        195                 200                 205             


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
    210                 215                 220                 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
225                 230                 235                 240 


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
                245                 250                 255     


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            260                 265                 270         


Val Glu Glu Asn Pro Gly Pro 
        275                 


<210>  46
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  46

Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val Pro Glu 
1               5                   10                  15      


Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp Ser Lys 
65                  70                  75                  80  


Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Ile Gly Gly Gly Ala 
                85                  90                  95      


Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro 
            100                 105                 110     


<210>  47
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  47

Met Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser 
            20      


<210>  48
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  48

Asn Ser Ala Ser Gln 
1               5   


<210>  49
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  49

Val Tyr Ser Ser Gly Asn 
1               5       


<210>  50
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  50

Val Val Ile Gly Gly Gly Ala Asp Gly Leu Thr 
1               5                   10      


<210>  51
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  51

Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln 
1               5                   10                  15      


Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His Asn Thr Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr 
        35                  40                  45              


Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Glu 
65                  70                  75                  80  


Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Val Gly Gly Asp 
                85                  90                  95      


Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val Glu Asp 
            100                 105                 110         


Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
        115                 120                 125             


Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
    130                 135                 140                 


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
145                 150                 155                 160 


Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln 
                165                 170                 175     


Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val 
            180                 185                 190         


Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val 
        195                 200                 205             


Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala 
    210                 215                 220                 


Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp 
225                 230                 235                 240 


Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
                245                 250                 255     


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
            260                 265                 270         


Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
        275                 280                 285         


<210>  52
<211>  110
<212>  PRT
<213>  Homo Sapiens

<400>  52

Gly Val Thr Gln Ser Pro Thr His Leu Ile Lys Thr Arg Gly Gln Gln 
1               5                   10                  15      


Val Thr Leu Arg Cys Ser Ser Gln Ser Gly His Asn Thr Val Ser Trp 
            20                  25                  30          


Tyr Gln Gln Ala Leu Gly Gln Gly Pro Gln Phe Ile Phe Gln Tyr Tyr 
        35                  40                  45              


Arg Glu Glu Glu Asn Gly Arg Gly Asn Phe Pro Pro Arg Phe Ser Gly 
    50                  55                  60                  


Leu Gln Phe Pro Asn Tyr Ser Ser Glu Leu Asn Val Asn Ala Leu Glu 
65                  70                  75                  80  


Leu Asp Asp Ser Ala Leu Tyr Leu Cys Ala Ser Ser Val Gly Gly Asp 
                85                  90                  95      


Thr Glu Ala Phe Phe Gly Gln Gly Thr Arg Leu Thr Val Val 
            100                 105                 110 


<210>  53
<211>  47
<212>  PRT
<213>  Homo Sapiens

<400>  53

Met Gly Arg Ile His Ser Ala Leu Pro Gln Glu Asp Gln Ala Leu Asn 
1               5                   10                  15      


Gln Val Gln Cys Cys Leu Pro His Cys Ala Met Gly Pro Gly Leu Leu 
            20                  25                  30          


Cys Trp Ala Leu Leu Cys Leu Leu Gly Ala Gly Ser Val Glu Thr 
        35                  40                  45          


<210>  54
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  54

Ser Gly His Asn Thr 
1               5   


<210>  55
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  55

Tyr Tyr Arg Glu Glu Glu 
1               5       


<210>  56
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  56

Ala Ser Ser Val Gly Gly Asp Thr Glu Ala Phe 
1               5                   10      


<210>  57
<211>  1836
<212>  DNA
<213>  Homo Sapiens

<400>  57
atgatgatat ccttgagagt tttactggtg atcctgtggc ttcagttaag ctgggtttgg       60

agccaacgga aggaggtgga gcaggatcct ggacccttca atgttccaga gggagccact      120

gtcgctttca actgtactta cagcaacagt gcttctcagt ctttcttctg gtacagacag      180

gattgcagga aagaacctaa gttgctgatg tccgtatact ccagtggtaa tgaagatgga      240

aggtttacag cacagctcaa tagagccagc cagtatattt ccctgctcat cagagactcc      300

aagctcagtg attcagccac ctacctctgt gtggtgatag gaggaggtgc tgacggactc      360

acctttggca aagggactca tctaatcatc cagccctata tccagaaccc tgaccctgcc      420

gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt      480

gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaatgct      540

gtgctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa      600

tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc      660

cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg      720

aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc      780

gggtttaatc tgctcatgac gctgcggctg tggtccagcc gtgccaagcg aagcggatct      840

ggcgccacga acttctctct gttaaagcaa gcaggagatg ttgaagaaaa ccccgggcct      900

atggatacct ggctcgtatg ctgggcaatt tttagtctct tgaaagcagg actcacagaa      960

cctgaagtca cccagactcc cagccatcag gtcacacaga tgggacagga agtgatcttg     1020

cgctgtgtcc ccatctctaa tcacttatac ttctattggt acagacaaat cttggggcag     1080

aaagtcgagt ttctggtttc cttttataat aatgaaatct cagagaagtc tgaaatattc     1140

gatgatcaat tctcagttga aaggcctgat ggatcaaatt tcactctgaa gatccggtcc     1200

acaaagctgg aggactcagc catgtacttc tgtgccagca gtggacaggg cgacttactc     1260

tatggctaca ccttcggttc ggggaccagg ttaaccgttg tagaggacct gaacaaggtg     1320

ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     1380

gccacactgg tgtgcctggc cacaggcttc ttccctgacc acgtggagct gagctggtgg     1440

gtgaatggga aggaggtgca cagtggggtc tgcacggacc cgcagcccct caaggagcag     1500

cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     1560

tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     1620

gacgagtgga cccaggatag ggccaaaccc gtcacccaga tcgtcagcgc cgaggcctgg     1680

ggtagagcag actgtggctt tacctcggtg tcctaccagc aaggggtcct gtctgccacc     1740

atcctctatg agatcctgct agggaaggcc accctgtatg ctgtgctggt cagcgccctt     1800

gtgttgatgg ccatggtcaa gagaaaggat ttctga                               1836


<210>  58
<211>  611
<212>  PRT
<213>  Homo Sapiens

<400>  58

Met Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro 
            20                  25                  30          


Phe Asn Val Pro Glu Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser 
        35                  40                  45              


Asn Ser Ala Ser Gln Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys 
    50                  55                  60                  


Glu Pro Lys Leu Leu Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly 
65                  70                  75                  80  


Arg Phe Thr Ala Gln Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu 
                85                  90                  95      


Ile Arg Asp Ser Lys Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val 
            100                 105                 110         


Ile Gly Gly Gly Ala Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu 
        115                 120                 125             


Ile Ile Gln Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Asn Ala Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Thr Trp 
    290                 295                 300                 


Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala Gly Leu Thr Glu 
305                 310                 315                 320 


Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly Gln 
                325                 330                 335     


Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe Tyr 
            340                 345                 350         


Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser Phe 
        355                 360                 365             


Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln Phe 
    370                 375                 380                 


Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg Ser 
385                 390                 395                 400 


Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Gly Gln 
                405                 410                 415     


Gly Asp Leu Leu Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu Thr 
            420                 425                 430         


Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe 
        435                 440                 445             


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    450                 455                 460                 


Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
465                 470                 475                 480 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro 
                485                 490                 495     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
            500                 505                 510         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
        515                 520                 525             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    530                 535                 540                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
545                 550                 555                 560 


Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val 
                565                 570                 575     


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
            580                 585                 590         


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
        595                 600                 605             


Lys Asp Phe 
    610     


<210>  59
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  59

Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val Pro Glu 
1               5                   10                  15      


Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp Ser Lys 
65                  70                  75                  80  


Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Ile Gly Gly Gly Ala 
                85                  90                  95      


Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro Tyr 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Asn Ala Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
        195                 200                 205             


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
    210                 215                 220                 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
225                 230                 235                 240 


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
                245                 250                 255     


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            260                 265                 270         


Val Glu Glu Asn Pro Gly Pro 
        275                 


<210>  60
<211>  111
<212>  PRT
<213>  Homo Sapiens

<400>  60

Gln Arg Lys Glu Val Glu Gln Asp Pro Gly Pro Phe Asn Val Pro Glu 
1               5                   10                  15      


Gly Ala Thr Val Ala Phe Asn Cys Thr Tyr Ser Asn Ser Ala Ser Gln 
            20                  25                  30          


Ser Phe Phe Trp Tyr Arg Gln Asp Cys Arg Lys Glu Pro Lys Leu Leu 
        35                  40                  45              


Met Ser Val Tyr Ser Ser Gly Asn Glu Asp Gly Arg Phe Thr Ala Gln 
    50                  55                  60                  


Leu Asn Arg Ala Ser Gln Tyr Ile Ser Leu Leu Ile Arg Asp Ser Lys 
65                  70                  75                  80  


Leu Ser Asp Ser Ala Thr Tyr Leu Cys Val Val Ile Gly Gly Gly Ala 
                85                  90                  95      


Asp Gly Leu Thr Phe Gly Lys Gly Thr His Leu Ile Ile Gln Pro 
            100                 105                 110     


<210>  61
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  61

Met Met Ile Ser Leu Arg Val Leu Leu Val Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Trp Val Trp Ser 
            20      


<210>  62
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  62

Asn Ser Ala Ser Gln Ser 
1               5       


<210>  63
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  63

Val Tyr Ser Ser Gly Asn 
1               5       


<210>  64
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  64

Val Val Ile Gly Gly Gly Ala Asp Gly Leu Thr 
1               5                   10      


<210>  65
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  65

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Gly 
                85                  90                  95      


Gln Gly Asp Leu Leu Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Val Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val 
        115                 120                 125             


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
    210                 215                 220                 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly 
                245                 250                 255     


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
            260                 265                 270         


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
        275                 280                 285             


Arg Lys Asp Phe 
    290         


<210>  66
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  66

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Gly 
                85                  90                  95      


Gln Gly Asp Leu Leu Tyr Gly Tyr Thr Phe Gly Ser Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Val 
        115 


<210>  67
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  67

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr 
            


<210>  68
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  68

Ser Asn His Leu Tyr 
1               5   


<210>  69
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  69

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  70
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  70

Ala Ser Ser Gly Gln Gly Asp Leu Leu Tyr Gly Tyr Thr 
1               5                   10              


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  71

Lys Ile Thr Asp Phe Gly Arg Ala Lys 
1               5                   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  72

Gly Ser Gly Gly Ser 
1               5   


<210>  73
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  73

Gly Gly Gly Ser 
1               


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  74

Gly Gly Ser Gly 
1               


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  75

Gly Gly Ser Gly Gly 
1               5   


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  76

Gly Ser Gly Ser Gly 
1               5   


<210>  77
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  77

Gly Ser Gly Gly Gly 
1               5   


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  78

Gly Gly Gly Ser Gly 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  79

Gly Ser Ser Ser Gly 
1               5   


