                               SEQUENCE LISTING

<110> PETRICHOR HEALTHCARE CAPITAL MANAGEMENT LP
 
<120> MEMBRANE PROTEIN TARGETING ENGINEERED DEUBIQUITINASES AND METHODS
      OF USE THEREOF

<130> 723693-PHG-004PC

<140> PCT/US2021/058291
<141> 2021-11-05

<150> 63/110,619
<151> 2020-11-06

<160> 448   

<170> PatentIn version 3.5

<210> 1
<211> 438
<212> PRT
<213> Homo sapiens

<400> 1
Met Cys Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys 
1               5                   10                  15      


Glu Glu Gln Gly Glu Ala Leu Lys Leu Gln Ala Ser Thr Ser Thr Glu 
            20                  25                  30          


Val Ser His Gln Gln Cys Ser Val Pro Gly Leu Gly Glu Lys Phe Pro 
        35                  40                  45              


Thr Trp Glu Thr Thr Lys Pro Glu Leu Glu Leu Leu Gly His Asn Pro 
    50                  55                  60                  


Arg Arg Arg Arg Ile Thr Ser Ser Phe Thr Ile Gly Leu Arg Gly Leu 
65                  70                  75                  80  


Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu 
                85                  90                  95      


Thr His Thr Pro Ile Leu Arg Asp Phe Phe Leu Ser Asp Arg His Arg 
            100                 105                 110         


Cys Glu Met Pro Ser Pro Glu Leu Cys Leu Val Cys Glu Met Ser Ser 
        115                 120                 125             


Leu Phe Arg Glu Leu Tyr Ser Gly Asn Pro Ser Pro His Val Pro Tyr 
    130                 135                 140                 


Lys Leu Leu His Leu Val Trp Ile His Ala Arg His Leu Ala Gly Tyr 
145                 150                 155                 160 


Arg Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp Val Leu 
                165                 170                 175     


His Arg His Cys Lys Gly Asp Asp Val Gly Lys Ala Ala Asn Asn Pro 
            180                 185                 190         


Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln 
        195                 200                 205             


Ser Asp Val Thr Cys Gln Ala Cys His Gly Val Ser Thr Thr Ile Asp 
    210                 215                 220                 


Pro Cys Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Thr Ser Phe 
225                 230                 235                 240 


Trp Pro Met Ser Pro Gly Arg Glu Ser Ser Val Asn Gly Glu Ser His 
                245                 250                 255     


Ile Pro Gly Ile Thr Thr Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg 
            260                 265                 270         


Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Gly Ser Cys Gln 
        275                 280                 285             


Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Asn Lys Leu Pro Val 
    290                 295                 300                 


Val Ala Cys Phe His Phe Lys Arg Phe Glu His Ser Ala Lys Gln Arg 
305                 310                 315                 320 


Arg Lys Ile Thr Thr Tyr Ile Ser Phe Pro Leu Glu Leu Asp Met Thr 
                325                 330                 335     


Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly Gln Leu Gln 
            340                 345                 350         


Leu Pro Thr Asn Ser Gly Asn Asn Glu Asn Lys Tyr Ser Leu Phe Ala 
        355                 360                 365             


Val Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe 
    370                 375                 380                 


Ile Arg His His Lys Asp Gln Trp Phe Lys Cys Asp Asp Ala Val Ile 
385                 390                 395                 400 


Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu 
                405                 410                 415     


Phe Tyr His Lys Gln Val Leu Glu His Glu Ser Glu Lys Val Lys Glu 
            420                 425                 430         


Met Asn Thr Gln Ala Tyr 
        435             


<210> 2
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp Leu Gln Lys 
                485                 490                 495     


Trp Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn His Ala Cys 
            500                 505                 510         


Leu Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser Ile Met Lys 
        515                 520                 525             


Arg Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg Tyr Gly Gly 
    530                 535                 540                 


Gly Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys Val Val Glu 
545                 550                 555                 560 


Arg Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu Asp Tyr Lys 
                565                 570                 575     


Thr Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Ser Asp Gly Phe 
            580                 585                 590         


Trp Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala Leu Glu 
        595                 600                 605             


Gln Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly Lys Met 
    610                 615                 620                 


Asn Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg Lys Glu 
625                 630                 635                 640 


Glu Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His Gly Glu 
                645                 650                 655     


Leu Cys Ile Ser Glu Asn Glu Arg Arg Leu Val Ser Lys Glu Ala Trp 
            660                 665                 670         


Ser Lys Leu Gln Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro Ser Tyr 
        675                 680                 685             


Lys Glu Cys Cys Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly Glu Glu 
    690                 695                 700                 


Asn Glu Ala Leu His Lys Met Ile Ala Asn Glu Gln Lys Thr Ser Leu 
705                 710                 715                 720 


Pro Asn Leu Phe Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn Trp Pro 
                725                 730                 735     


Glu Asp Thr Asp Val Leu Tyr Ile Val Ser Gln Phe Phe Val Glu Glu 
            740                 745                 750         


Trp Arg Lys Phe Val Arg Lys Pro Thr Arg Cys Ser Pro Val Ser Ser 
        755                 760                 765             


Val Gly Asn Ser Ala Leu Leu Cys Pro His Gly Gly Leu Met Phe Thr 
    770                 775                 780                 


Phe Ala Ser Met Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu Ile Trp 
785                 790                 795                 800 


Pro Ser Glu Trp Gln Met Ile Gln Lys Leu Phe Val Val Asp His Val 
                805                 810                 815     


Ile Lys Ile Thr Arg Ile Glu Val Gly Asp Val Asn Pro Ser Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ser Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu Gly Leu 
        835                 840                 845             


Leu Cys Gln Gln Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala Thr Ile 
    850                 855                 860                 


Tyr Val His Lys Val Val Asp Asn Lys Lys Val Met Lys Asp Ser Ala 
865                 870                 875                 880 


Pro Glu Leu Asn Val Ser Ser Ser Glu Thr Glu Glu Asp Lys Glu Glu 
                885                 890                 895     


Ala Lys Pro Asp Gly Glu Lys Asp Pro Asp Phe Asn Gln Ser Asn Gly 
            900                 905                 910         


Gly Thr Lys Arg Gln Lys Ile Ser His Gln Asn Tyr Ile Ala Tyr Gln 
        915                 920                 925             


Lys Gln Val Ile Arg Arg Ser Met Arg His Arg Lys Val Arg Gly Glu 
    930                 935                 940                 


Lys Ala Leu Leu Val Ser Ala Asn Gln Thr Leu Lys Glu Leu Lys Ile 
945                 950                 955                 960 


Gln Ile Met His Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser 
                965                 970                 975     


Ile Asp Gly Lys Ile Leu Ser Asp Asp Cys Ala Thr Leu Gly Thr Leu 
            980                 985                 990         


Gly Val Ile Pro Glu Ser Val Ile  Leu Leu Lys Ala Asp  Glu Pro Ile 
        995                 1000                 1005             


Ala Asp  Tyr Ala Ala Met Asp  Asp Val Met Gln Val  Cys Met Pro 
    1010                 1015                 1020             


Glu Glu  Gly Phe Lys Gly Thr  Gly Leu Leu Gly His  
    1025                 1030                 1035 


<210> 3
<211> 520
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210> 4
<211> 470
<212> PRT
<213> Homo sapiens

<400> 4
Gln Leu Ala Pro Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala 
1               5                   10                  15      


Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
            20                  25                  30          


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
        35                  40                  45              


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
    50                  55                  60                  


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
65                  70                  75                  80  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
                85                  90                  95      


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
            100                 105                 110         


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
        115                 120                 125             


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
    130                 135                 140                 


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
145                 150                 155                 160 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
                165                 170                 175     


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
            180                 185                 190         


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
        195                 200                 205             


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
    210                 215                 220                 


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
225                 230                 235                 240 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
                245                 250                 255     


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
            260                 265                 270         


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
        275                 280                 285             


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
    290                 295                 300                 


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
305                 310                 315                 320 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
                325                 330                 335     


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
            340                 345                 350         


Pro Cys Leu Gln Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala 
        355                 360                 365             


Thr Gln Glu Ser Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn 
    370                 375                 380                 


Lys Thr Lys Pro Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro 
385                 390                 395                 400 


Pro Asp Val Leu Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys 
                405                 410                 415     


Asn His His Pro Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr 
            420                 425                 430         


Thr Pro Thr His Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu 
        435                 440                 445             


Arg Gly Arg Ala Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg 
    450                 455                 460                 


Ala Leu Leu Val Cys Gln 
465                 470 


<210> 5
<211> 785
<212> PRT
<213> Homo sapiens

<400> 5
Met Pro Gly Val Ile Pro Ser Glu Ser Asn Gly Leu Ser Arg Gly Ser 
1               5                   10                  15      


Pro Ser Lys Lys Asn Arg Leu Ser Leu Lys Phe Phe Gln Lys Lys Glu 
            20                  25                  30          


Thr Lys Arg Ala Leu Asp Phe Thr Asp Ser Gln Glu Asn Glu Glu Lys 
        35                  40                  45              


Ala Ser Glu Tyr Arg Ala Ser Glu Ile Asp Gln Val Val Pro Ala Ala 
    50                  55                  60                  


Gln Ser Ser Pro Ile Asn Cys Glu Lys Arg Glu Asn Leu Leu Pro Phe 
65                  70                  75                  80  


Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn Ser Ile Leu 
                85                  90                  95      


Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val Lys His Leu 
            100                 105                 110         


Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp Glu Ala Asn 
        115                 120                 125             


Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala Ser Tyr Glu 
    130                 135                 140                 


Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu Gln Leu Gln 
145                 150                 155                 160 


Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu Leu Ala Thr 
                165                 170                 175     


Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn Pro Met Tyr 
            180                 185                 190         


Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln Cys Ile Leu 
        195                 200                 205             


Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu Glu Val Lys 
    210                 215                 220                 


Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro His Pro Lys 
225                 230                 235                 240 


Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser Met Arg His 
                245                 250                 255     


Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly Lys Arg Lys 
            260                 265                 270         


Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys Leu Ser Lys 
        275                 280                 285             


Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg Ser Lys Arg 
    290                 295                 300                 


Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile Ile Pro Lys 
305                 310                 315                 320 


Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys Lys Ser Arg 
                325                 330                 335     


Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro Ser Ile Leu 
            340                 345                 350         


Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln Gly Val Lys 
        355                 360                 365             


Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp Leu Gly Lys 
    370                 375                 380                 


Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu Ser Pro Gly 
385                 390                 395                 400 


Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro Ile Asn Lys 
                405                 410                 415     


Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu Phe Gln Gly 
            420                 425                 430         


Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser Leu Thr Glu 
        435                 440                 445             


Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln Glu Asp Glu 
    450                 455                 460                 


Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu Pro Lys Thr 
465                 470                 475                 480 


Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala Ser Val Glu 
                485                 490                 495     


Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys His His Tyr 
            500                 505                 510         


Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro Glu Val Ile 
        515                 520                 525             


Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu Phe Asp Cys 
    530                 535                 540                 


Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu Thr Pro Leu 
545                 550                 555                 560 


Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn Asp Ser Tyr 
                565                 570                 575     


Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile Ser Ser Gly 
            580                 585                 590         


His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser Leu Glu Leu 
        595                 600                 605             


Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile Gly Lys Pro 
    610                 615                 620                 


Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu Asn Tyr Asn 
625                 630                 635                 640 


Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln Pro Ser Lys 
                645                 650                 655     


Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu Gly Gly Gln 
            660                 665                 670         


Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser Asn Pro Asp 
        675                 680                 685             


Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser Glu Thr Ser 
    690                 695                 700                 


Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu Ser Ser Asp 
705                 710                 715                 720 


Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile Ser Tyr Val 
                725                 730                 735     


Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu Phe Asp Asp 
            740                 745                 750         


Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn Ser Leu Ser 
        755                 760                 765             


Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe Tyr Lys Lys 
    770                 775                 780                 


Leu 
785 


<210> 6
<211> 1235
<212> PRT
<213> Homo sapiens

<400> 6
Met Phe Gly Asp Leu Phe Glu Glu Glu Tyr Ser Thr Val Ser Asn Asn 
1               5                   10                  15      


Gln Tyr Gly Lys Gly Lys Lys Leu Lys Thr Lys Ala Leu Glu Pro Pro 
            20                  25                  30          


Ala Pro Arg Glu Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly 
        35                  40                  45              


Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu 
    50                  55                  60                  


Phe Arg Glu Ala Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe 
65                  70                  75                  80  


Glu Asp Lys Asp Lys Pro Asp Ala Lys Val Arg Ile Ile Pro Leu Gln 
                85                  90                  95      


Leu Gln Arg Leu Phe Ala Gln Leu Leu Leu Leu Asp Gln Glu Ala Ala 
            100                 105                 110         


Ser Thr Ala Asp Leu Thr Asp Ser Phe Gly Trp Thr Ser Asn Glu Glu 
        115                 120                 125             


Met Arg Gln His Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala 
    130                 135                 140                 


Leu Glu Thr Ser Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg 
145                 150                 155                 160 


Leu Tyr His Gly Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys 
                165                 170                 175     


Asn Val Ser Glu Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val 
            180                 185                 190         


Lys Asn Val Ser Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu 
        195                 200                 205             


Glu Glu Val Phe Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp 
    210                 215                 220                 


Arg Leu Val Lys Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro 
225                 230                 235                 240 


Phe Leu Thr Val Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys 
                245                 250                 255     


Glu Arg Tyr Lys Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn 
            260                 265                 270         


Leu Lys Pro Phe Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile 
        275                 280                 285             


Tyr Asp Leu Phe Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly 
    290                 295                 300                 


His Tyr His Val Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln 
305                 310                 315                 320 


Phe Gln Glu Glu Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln 
                325                 330                 335     


Ser Glu Glu Glu Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu 
            340                 345                 350         


Leu Glu Glu Asn Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu 
        355                 360                 365             


Leu Lys Lys Ile Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His 
    370                 375                 380                 


Gly Pro Leu Arg Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu 
385                 390                 395                 400 


Ser Ser Asp Glu Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln 
                405                 410                 415     


Ala Glu Ser Asp Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu 
            420                 425                 430         


Pro Pro Glu Ser Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp 
        435                 440                 445             


Phe Asp Ile Asn Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile 
    450                 455                 460                 


Glu Gln Gln Phe Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg 
465                 470                 475                 480 


Lys Ser Gln Leu Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr 
                485                 490                 495     


Gly Val Pro Cys His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu 
            500                 505                 510         


Leu Gln Thr Lys Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu 
        515                 520                 525             


Leu His Leu His Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu 
    530                 535                 540                 


His Pro Val Val Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp 
545                 550                 555                 560 


Lys Arg Lys Thr Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu 
                565                 570                 575     


Glu Phe Trp Glu Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro 
            580                 585                 590         


Ala Gly Leu His Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu 
        595                 600                 605             


Cys Glu Thr Glu Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly 
    610                 615                 620                 


Val Glu Val Gly Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro 
625                 630                 635                 640 


Leu Leu Leu Asn Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys 
                645                 650                 655     


Cys Cys Gln Val Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu 
            660                 665                 670         


Val Gly Thr Val Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe 
        675                 680                 685             


Ile Asn Ser Ala Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro 
    690                 695                 700                 


Lys Glu Asp Met Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly 
705                 710                 715                 720 


Ser Ser Ile Leu Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr 
                725                 730                 735     


Lys Glu Glu Lys Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His 
            740                 745                 750         


Val Lys Asn Leu Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile 
        755                 760                 765             


Ser Ala Thr Val Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile 
    770                 775                 780                 


Lys Glu Leu Lys Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg 
785                 790                 795                 800 


Pro Ile Asp Arg Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr 
                805                 810                 815     


Thr Leu Lys Glu Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys 
            820                 825                 830         


Leu Gly Lys Ala Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met 
        835                 840                 845             


Gly Ser Asp Val Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu 
    850                 855                 860                 


Thr Ile Ser Val Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly 
865                 870                 875                 880 


Leu Gln Gly Asp Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu 
                885                 890                 895     


Ala Gly Glu Pro Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu 
            900                 905                 910         


Ile Cys Ser Gly Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro 
        915                 920                 925             


Leu Gly Phe Leu Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro 
    930                 935                 940                 


Ser Gly His Trp Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser 
945                 950                 955                 960 


Trp Gly Arg Val Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn 
                965                 970                 975     


Glu Pro Ala Gln Val Ser Leu Leu Tyr Leu Gly Asp Ile Glu Ile Ser 
            980                 985                 990         


Glu Asp Ala Thr Leu Ala Glu Leu  Lys Ser Gln Ala Met  Thr Leu Pro 
        995                 1000                 1005             


Pro Phe  Leu Glu Phe Gly Val  Pro Ser Pro Ala His  Leu Arg Ala 
    1010                 1015                 1020             


Trp Thr  Val Glu Arg Lys Arg  Pro Gly Arg Leu Leu  Arg Thr Asp 
    1025                 1030                 1035             


Arg Gln  Pro Leu Arg Glu Tyr  Lys Leu Gly Arg Arg  Ile Glu Ile 
    1040                 1045                 1050             


Cys Leu  Glu Pro Leu Gln Lys  Gly Glu Asn Leu Gly  Pro Gln Asp 
    1055                 1060                 1065             


Val Leu  Leu Arg Thr Gln Val  Arg Ile Pro Gly Glu  Arg Thr Tyr 
    1070                 1075                 1080             


Ala Pro  Ala Leu Asp Leu Val  Trp Asn Ala Ala Gln  Gly Gly Thr 
    1085                 1090                 1095             


Ala Gly  Ser Leu Arg Gln Arg  Val Ala Asp Phe Tyr  Arg Leu Pro 
    1100                 1105                 1110             


Val Glu  Lys Ile Glu Ile Ala  Lys Tyr Phe Pro Glu  Lys Phe Glu 
    1115                 1120                 1125             


Trp Leu  Pro Ile Ser Ser Trp  Asn Gln Gln Ile Thr  Lys Arg Lys 
    1130                 1135                 1140             


Lys Lys  Lys Lys Gln Asp Tyr  Leu Gln Gly Ala Pro  Tyr Tyr Leu 
    1145                 1150                 1155             


Lys Asp  Gly Asp Thr Ile Gly  Val Lys Asn Leu Leu  Ile Asp Asp 
    1160                 1165                 1170             


Asp Asp  Asp Phe Ser Thr Ile  Arg Asp Asp Thr Gly  Lys Glu Lys 
    1175                 1180                 1185             


Gln Lys  Gln Arg Ala Leu Gly  Arg Arg Lys Ser Gln  Glu Ala Leu 
    1190                 1195                 1200             


His Glu  Gln Ser Ser Tyr Ile  Leu Ser Ser Ala Glu  Thr Pro Ala 
    1205                 1210                 1215             


Arg Pro  Arg Ala Pro Glu Thr  Ser Leu Ser Ile His  Val Gly Ser 
    1220                 1225                 1230             


Phe Arg  
    1235 


<210> 7
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln 
1               5                   10                  15      


Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp 
            20                  25                  30          


Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu 
        35                  40                  45              


Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser 
    50                  55                  60                  


Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg 
65                  70                  75                  80  


Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro 
                85                  90                  95      


Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln 
            100                 105                 110         


Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr 
        115                 120                 125             


Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg 
    130                 135                 140                 


Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His 
145                 150                 155                 160 


Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val 
                165                 170                 175     


Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu 
            180                 185                 190         


Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys 
        195                 200                 205             


Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr 
    210                 215                 220                 


Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys 
225                 230                 235                 240 


Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val 
                245                 250                 255     


Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys 
            260                 265                 270         


Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu 
        275                 280                 285             


Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu 
    290                 295                 300                 


Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu 
                325                 330                 335     


Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu 
            340                 345                 350         


Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val 
        355                 360                 365             


Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His 
    370                 375                 380                 


Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro 
385                 390                 395                 400 


Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp 
                405                 410                 415     


Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro 
            420                 425                 430         


Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr 
        435                 440                 445             


Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His 
    450                 455                 460                 


Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe 
465                 470                 475                 480 


Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His 
                485                 490                 495     


Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn 
            500                 505                 510         


Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu 
        515                 520                 525             


Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu 
    530                 535                 540                 


Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu 
545                 550                 555                 560 


Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys 
                565                 570                 575     


Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr 
            580                 585                 590         


Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser 
        595                 600                 605             


Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro 
    610                 615                 620                 


Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn 
625                 630                 635                 640 


Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn 
                645                 650                 655     


Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser 
            660                 665                 670         


Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe 
        675                 680                 685             


Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His 
    690                 695                 700                 


Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met 
705                 710                 715                 720 


Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu 
                725                 730                 735     


Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser 
            740                 745                 750         


Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe 
        755                 760                 765             


Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys 
    770                 775                 780                 


Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp 
785                 790                 795                 800 


Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg 
                805                 810                 815     


Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr 
            820                 825                 830         


Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly 
        835                 840                 845             


Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu 
    850                 855                 860                 


Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln 
865                 870                 875                 880 


Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys 
                885                 890                 895     


Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro 
            900                 905                 910         


Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala 
        915                 920                 925             


Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile 
    930                 935                 940                 


Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu 
945                 950                 955                 960 


Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro 
                965                 970                 975     


Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val 
            980                 985                 990         


Ala His Phe His Lys Glu Val Phe  Gly Thr Phe Gly Ile  Pro Phe Leu 
        995                 1000                 1005             


Leu Arg  Ile His Gln Gly Glu  His Phe Arg Glu Val  Met Lys Arg 
    1010                 1015                 1020             


Ile Gln  Ser Leu Leu Asp Ile  Gln Glu Lys Glu Phe  Glu Lys Phe 
    1025                 1030                 1035             


Lys Phe  Ala Ile Val Met Met  Gly Arg His Gln Tyr  Ile Asn Glu 
    1040                 1045                 1050             


Asp Glu  Tyr Glu Val Asn Leu  Lys Asp Phe Glu Pro  Gln Pro Gly 
    1055                 1060                 1065             


Asn Met  Ser His Pro Arg Pro  Trp Leu Gly Leu Asp  His Phe Asn 
    1070                 1075                 1080             


Lys Ala  Pro Lys Arg Ser Arg  Tyr Thr Tyr Leu Glu  Lys Ala Ile 
    1085                 1090                 1095             


Lys Ile  His Asn 
    1100         


<210> 8
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Ala Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 9
<211> 530
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Asn Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr Leu Leu Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 10
<211> 530
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Pro Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Lys Pro Pro Leu Ala Asn Tyr Met Leu Phe Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Ile Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Arg Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp Arg His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Asn Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Pro Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Ser 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Val Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Arg Val Glu Gly Thr Val Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Arg Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 11
<211> 358
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Gly Val Leu Phe Arg Ala His Gln Cys Gln Tyr Val His Pro 
1               5                   10                  15      


Cys Val His Val Tyr Val Thr Val Gly Leu Met Asp Pro Leu Cys Glu 
            20                  25                  30          


Arg Lys Glu Lys Ala Ser Lys Gln Glu Arg Glu Asn Pro Leu Ala His 
        35                  40                  45              


Leu Ala Ala Trp Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Ala 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Trp Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Tyr Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Ala Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Met Ile Arg Met Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Leu Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Arg Leu Ser Phe Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp 
        355             


<210> 12
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 12
Met Asp Lys Ile Leu Glu Gly Leu Val Ser Ser Ser His Pro Leu Pro 
1               5                   10                  15      


Leu Lys Arg Val Ile Val Arg Lys Val Val Glu Ser Ala Glu His Trp 
            20                  25                  30          


Leu Asp Glu Ala Gln Cys Glu Ala Met Phe Asp Leu Thr Thr Arg Leu 
        35                  40                  45              


Ile Leu Glu Gly Gln Asp Pro Phe Gln Arg Gln Val Gly His Gln Val 
    50                  55                  60                  


Leu Glu Ala Tyr Ala Arg Tyr His Arg Pro Glu Phe Glu Ser Phe Phe 
65                  70                  75                  80  


Asn Lys Thr Phe Val Leu Gly Leu Leu His Gln Gly Tyr His Ser Leu 
                85                  90                  95      


Asp Arg Lys Asp Val Ala Ile Leu Asp Tyr Ile His Asn Gly Leu Lys 
            100                 105                 110         


Leu Ile Met Ser Cys Pro Ser Val Leu Asp Leu Phe Ser Leu Leu Gln 
        115                 120                 125             


Val Glu Val Leu Arg Met Val Cys Glu Arg Pro Glu Pro Gln Leu Cys 
    130                 135                 140                 


Ala Arg Leu Ser Asp Leu Leu Thr Asp Phe Val Gln Cys Ile Pro Lys 
145                 150                 155                 160 


Gly Lys Leu Ser Ile Thr Phe Cys Gln Gln Leu Val Arg Thr Ile Gly 
                165                 170                 175     


His Phe Gln Cys Val Ser Thr Gln Glu Arg Glu Leu Arg Glu Tyr Val 
            180                 185                 190         


Ser Gln Val Thr Lys Val Ser Asn Leu Leu Gln Asn Ile Trp Lys Ala 
        195                 200                 205             


Glu Pro Ala Thr Leu Leu Pro Ser Leu Gln Glu Val Phe Ala Ser Ile 
    210                 215                 220                 


Ser Ser Thr Asp Ala Ser Phe Glu Pro Ser Val Ala Leu Ala Ser Leu 
225                 230                 235                 240 


Val Gln His Ile Pro Leu Gln Met Ile Thr Val Leu Ile Arg Ser Leu 
                245                 250                 255     


Thr Thr Asp Pro Asn Val Lys Asp Ala Ser Met Thr Gln Ala Leu Cys 
            260                 265                 270         


Arg Met Ile Asp Trp Leu Ser Trp Pro Leu Ala Gln His Val Asp Thr 
        275                 280                 285             


Trp Val Ile Ala Leu Leu Lys Gly Leu Ala Ala Val Gln Lys Phe Thr 
    290                 295                 300                 


Ile Leu Ile Asp Val Thr Leu Leu Lys Ile Glu Leu Val Phe Asn Arg 
305                 310                 315                 320 


Leu Trp Phe Pro Leu Val Arg Pro Gly Ala Leu Ala Val Leu Ser His 
                325                 330                 335     


Met Leu Leu Ser Phe Gln His Ser Pro Glu Ala Phe His Leu Ile Val 
            340                 345                 350         


Pro His Val Val Asn Leu Val His Ser Phe Lys Asn Asp Gly Leu Pro 
        355                 360                 365             


Ser Ser Thr Ala Phe Leu Val Gln Leu Thr Glu Leu Ile His Cys Met 
    370                 375                 380                 


Met Tyr His Tyr Ser Gly Phe Pro Asp Leu Tyr Glu Pro Ile Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asp Phe Pro Lys Pro Ser Glu Glu Lys Ile Lys Leu Ile 
                405                 410                 415     


Leu Asn Gln Ser Ala Trp Thr Ser Gln Ser Asn Ser Leu Ala Ser Cys 
            420                 425                 430         


Leu Ser Arg Leu Ser Gly Lys Ser Glu Thr Gly Lys Thr Gly Leu Ile 
        435                 440                 445             


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Val Ile Gln Ala Leu Phe 
    450                 455                 460                 


Met Ala Thr Asp Phe Arg Arg Gln Val Leu Ser Leu Asn Leu Asn Gly 
465                 470                 475                 480 


Cys Asn Ser Leu Met Lys Lys Leu Gln His Leu Phe Ala Phe Leu Ala 
                485                 490                 495     


His Thr Gln Arg Glu Ala Tyr Ala Pro Arg Ile Phe Phe Glu Ala Ser 
            500                 505                 510         


Arg Pro Pro Trp Phe Thr Pro Arg Ser Gln Gln Asp Cys Ser Glu Tyr 
        515                 520                 525             


Leu Arg Phe Leu Leu Asp Arg Leu His Glu Glu Glu Lys Ile Leu Lys 
    530                 535                 540                 


Val Gln Ala Ser His Lys Pro Ser Glu Ile Leu Glu Cys Ser Glu Thr 
545                 550                 555                 560 


Ser Leu Gln Glu Val Ala Ser Lys Ala Ala Val Leu Thr Glu Thr Pro 
                565                 570                 575     


Arg Thr Ser Asp Gly Glu Lys Thr Leu Ile Glu Lys Met Phe Gly Gly 
            580                 585                 590         


Lys Leu Arg Thr His Ile Arg Cys Leu Asn Cys Arg Ser Thr Ser Gln 
        595                 600                 605             


Lys Val Glu Ala Phe Thr Asp Leu Ser Leu Ala Phe Cys Pro Ser Ser 
    610                 615                 620                 


Ser Leu Glu Asn Met Ser Val Gln Asp Pro Ala Ser Ser Pro Ser Ile 
625                 630                 635                 640 


Gln Asp Gly Gly Leu Met Gln Ala Ser Val Pro Gly Pro Ser Glu Glu 
                645                 650                 655     


Pro Val Val Tyr Asn Pro Thr Thr Ala Ala Phe Ile Cys Asp Ser Leu 
            660                 665                 670         


Val Asn Glu Lys Thr Ile Gly Ser Pro Pro Asn Glu Phe Tyr Cys Ser 
        675                 680                 685             


Glu Asn Thr Ser Val Pro Asn Glu Ser Asn Lys Ile Leu Val Asn Lys 
    690                 695                 700                 


Asp Val Pro Gln Lys Pro Gly Gly Glu Thr Thr Pro Ser Val Thr Asp 
705                 710                 715                 720 


Leu Leu Asn Tyr Phe Leu Ala Pro Glu Ile Leu Thr Gly Asp Asn Gln 
                725                 730                 735     


Tyr Tyr Cys Glu Asn Cys Ala Ser Leu Gln Asn Ala Glu Lys Thr Met 
            740                 745                 750         


Gln Ile Thr Glu Glu Pro Glu Tyr Leu Ile Leu Thr Leu Leu Arg Phe 
        755                 760                 765             


Ser Tyr Asp Gln Lys Tyr His Val Arg Arg Lys Ile Leu Asp Asn Val 
    770                 775                 780                 


Ser Leu Pro Leu Val Leu Glu Leu Pro Val Lys Arg Ile Thr Ser Phe 
785                 790                 795                 800 


Ser Ser Leu Ser Glu Ser Trp Ser Val Asp Val Asp Phe Thr Asp Leu 
                805                 810                 815     


Ser Glu Asn Leu Ala Lys Lys Leu Lys Pro Ser Gly Thr Asp Glu Ala 
            820                 825                 830         


Ser Cys Thr Lys Leu Val Pro Tyr Leu Leu Ser Ser Val Val Val His 
        835                 840                 845             


Ser Gly Ile Ser Ser Glu Ser Gly His Tyr Tyr Ser Tyr Ala Arg Asn 
    850                 855                 860                 


Ile Thr Ser Thr Asp Ser Ser Tyr Gln Met Tyr His Gln Ser Glu Ala 
865                 870                 875                 880 


Leu Ala Leu Ala Ser Ser Gln Ser His Leu Leu Gly Arg Asp Ser Pro 
                885                 890                 895     


Ser Ala Val Phe Glu Gln Asp Leu Glu Asn Lys Glu Met Ser Lys Glu 
            900                 905                 910         


Trp Phe Leu Phe Asn Asp Ser Arg Val Thr Phe Thr Ser Phe Gln Ser 
        915                 920                 925             


Val Gln Lys Ile Thr Ser Arg Phe Pro Lys Asp Thr Ala Tyr Val Leu 
    930                 935                 940                 


Leu Tyr Lys Lys Gln His Ser Thr Asn Gly Leu Ser Gly Asn Asn Pro 
945                 950                 955                 960 


Thr Ser Gly Leu Trp Ile Asn Gly Asp Pro Pro Leu Gln Lys Glu Leu 
                965                 970                 975     


Met Asp Ala Ile Thr Lys Asp Asn Lys Leu Tyr Leu Gln Glu Gln Glu 
            980                 985                 990         


Leu Asn Ala Arg Ala Arg Ala Leu  Gln Ala Ala Ser Ala  Ser Cys Ser 
        995                 1000                 1005             


Phe Arg  Pro Asn Gly Phe Asp  Asp Asn Asp Pro Pro  Gly Ser Cys 
    1010                 1015                 1020             


Gly Pro  Thr Gly Gly Gly Gly  Gly Gly Gly Phe Asn  Thr Val Gly 
    1025                 1030                 1035             


Arg Leu  Val Phe 
    1040         


<210> 13
<211> 1123
<212> PRT
<213> Homo sapiens

<400> 13
Met Asp Leu Gly Pro Gly Asp Ala Ala Gly Gly Gly Pro Leu Ala Pro 
1               5                   10                  15      


Arg Pro Arg Arg Arg Arg Ser Leu Arg Arg Leu Phe Ser Arg Phe Leu 
            20                  25                  30          


Leu Ala Leu Gly Ser Arg Ser Arg Pro Gly Asp Ser Pro Pro Arg Pro 
        35                  40                  45              


Gln Pro Gly His Cys Asp Gly Asp Gly Glu Gly Gly Phe Ala Cys Ala 
    50                  55                  60                  


Pro Gly Pro Val Pro Ala Ala Pro Gly Ser Pro Gly Glu Glu Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Gln Pro Gln Leu Gln Leu Pro Ala Gly Asp Gly Ala Arg 
                85                  90                  95      


Pro Pro Gly Ala Gln Gly Leu Lys Asn His Gly Asn Thr Cys Phe Met 
            100                 105                 110         


Asn Ala Val Val Gln Cys Leu Ser Asn Thr Asp Leu Leu Ala Glu Phe 
        115                 120                 125             


Leu Ala Leu Gly Arg Tyr Arg Ala Ala Pro Gly Arg Ala Glu Val Thr 
    130                 135                 140                 


Glu Gln Leu Ala Ala Leu Val Arg Ala Leu Trp Thr Arg Glu Tyr Thr 
145                 150                 155                 160 


Pro Gln Leu Ser Ala Glu Phe Lys Asn Ala Val Ser Lys Tyr Gly Ser 
                165                 170                 175     


Gln Phe Gln Gly Asn Ser Gln His Asp Ala Leu Glu Phe Leu Leu Trp 
            180                 185                 190         


Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly Ser Ser Arg Gly Pro 
        195                 200                 205             


Val Ser Glu Lys Leu Pro Pro Glu Ala Thr Lys Thr Ser Glu Asn Cys 
    210                 215                 220                 


Leu Ser Pro Ser Ala Gln Leu Pro Leu Gly Gln Ser Phe Val Gln Ser 
225                 230                 235                 240 


His Phe Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys Leu 
                245                 250                 255     


Lys Gln Ser Asn Thr Phe Asp Pro Phe Leu Cys Val Ser Leu Pro Ile 
            260                 265                 270         


Pro Leu Arg Gln Thr Arg Phe Leu Ser Val Thr Leu Val Phe Pro Ser 
        275                 280                 285             


Lys Ser Gln Arg Phe Leu Arg Val Gly Leu Ala Val Pro Ile Leu Ser 
    290                 295                 300                 


Thr Val Ala Ala Leu Arg Lys Met Val Ala Glu Glu Gly Gly Val Pro 
305                 310                 315                 320 


Ala Asp Glu Val Ile Leu Val Glu Leu Tyr Pro Ser Gly Phe Gln Arg 
                325                 330                 335     


Ser Phe Phe Asp Glu Glu Asp Leu Asn Thr Ile Ala Glu Gly Asp Asn 
            340                 345                 350         


Val Tyr Ala Phe Gln Val Pro Pro Ser Pro Ser Gln Gly Thr Leu Ser 
        355                 360                 365             


Ala His Pro Leu Gly Leu Ser Ala Ser Pro Arg Leu Ala Ala Arg Glu 
    370                 375                 380                 


Gly Gln Arg Phe Ser Leu Ser Leu His Ser Glu Ser Lys Val Leu Ile 
385                 390                 395                 400 


Leu Phe Cys Asn Leu Val Gly Ser Gly Gln Gln Ala Ser Arg Phe Gly 
                405                 410                 415     


Pro Pro Phe Leu Ile Arg Glu Asp Arg Ala Val Ser Trp Ala Gln Leu 
            420                 425                 430         


Gln Gln Ser Ile Leu Ser Lys Val Arg His Leu Met Lys Ser Glu Ala 
        435                 440                 445             


Pro Val Gln Asn Leu Gly Ser Leu Phe Ser Ile Arg Val Val Gly Leu 
    450                 455                 460                 


Ser Val Ala Cys Ser Tyr Leu Ser Pro Lys Asp Ser Arg Pro Leu Cys 
465                 470                 475                 480 


His Trp Ala Val Asp Arg Val Leu His Leu Arg Arg Pro Gly Gly Pro 
                485                 490                 495     


Pro His Val Lys Leu Ala Val Glu Trp Asp Ser Ser Val Lys Glu Arg 
            500                 505                 510         


Leu Phe Gly Ser Leu Gln Glu Glu Arg Ala Gln Asp Ala Asp Ser Val 
        515                 520                 525             


Trp Gln Gln Gln Gln Ala His Gln Gln His Ser Cys Thr Leu Asp Glu 
    530                 535                 540                 


Cys Phe Gln Phe Tyr Thr Lys Glu Glu Gln Leu Ala Gln Asp Asp Ala 
545                 550                 555                 560 


Trp Lys Cys Pro His Cys Gln Val Leu Gln Gln Gly Met Val Lys Leu 
                565                 570                 575     


Ser Leu Trp Thr Leu Pro Asp Ile Leu Ile Ile His Leu Lys Arg Phe 
            580                 585                 590         


Cys Gln Val Gly Glu Arg Arg Asn Lys Leu Ser Thr Leu Val Lys Phe 
        595                 600                 605             


Pro Leu Ser Gly Leu Asn Met Ala Pro His Val Ala Gln Arg Ser Thr 
    610                 615                 620                 


Ser Pro Glu Ala Gly Leu Gly Pro Trp Pro Ser Trp Lys Gln Pro Asp 
625                 630                 635                 640 


Cys Leu Pro Thr Ser Tyr Pro Leu Asp Phe Leu Tyr Asp Leu Tyr Ala 
                645                 650                 655     


Val Cys Asn His His Gly Asn Leu Gln Gly Gly His Tyr Thr Ala Tyr 
            660                 665                 670         


Cys Arg Asn Ser Leu Asp Gly Gln Trp Tyr Ser Tyr Asp Asp Ser Thr 
        675                 680                 685             


Val Glu Pro Leu Arg Glu Asp Glu Val Asn Thr Arg Gly Ala Tyr Ile 
    690                 695                 700                 


Leu Phe Tyr Gln Lys Arg Asn Ser Ile Pro Pro Trp Ser Ala Ser Ser 
705                 710                 715                 720 


Ser Met Arg Gly Ser Thr Ser Ser Ser Leu Ser Asp His Trp Leu Leu 
                725                 730                 735     


Arg Leu Gly Ser His Ala Gly Ser Thr Arg Gly Ser Leu Leu Ser Trp 
            740                 745                 750         


Ser Ser Ala Pro Cys Pro Ser Leu Pro Gln Val Pro Asp Ser Pro Ile 
        755                 760                 765             


Phe Thr Asn Ser Leu Cys Asn Gln Glu Lys Gly Gly Leu Glu Pro Arg 
    770                 775                 780                 


Arg Leu Val Arg Gly Val Lys Gly Arg Ser Ile Ser Met Lys Ala Pro 
785                 790                 795                 800 


Thr Thr Ser Arg Ala Lys Gln Gly Pro Phe Lys Thr Met Pro Leu Arg 
                805                 810                 815     


Trp Ser Phe Gly Ser Lys Glu Lys Pro Pro Gly Ala Ser Val Glu Leu 
            820                 825                 830         


Val Glu Tyr Leu Glu Ser Arg Arg Arg Pro Arg Ser Thr Ser Gln Ser 
        835                 840                 845             


Ile Val Ser Leu Leu Thr Gly Thr Ala Gly Glu Asp Glu Lys Ser Ala 
    850                 855                 860                 


Ser Pro Arg Ser Asn Val Ala Leu Pro Ala Asn Ser Glu Asp Gly Gly 
865                 870                 875                 880 


Arg Ala Ile Glu Arg Gly Pro Ala Gly Val Pro Cys Pro Ser Ala Gln 
                885                 890                 895     


Pro Asn His Cys Leu Ala Pro Gly Asn Ser Asp Gly Pro Asn Thr Ala 
            900                 905                 910         


Arg Lys Leu Lys Glu Asn Ala Gly Gln Asp Ile Lys Leu Pro Arg Lys 
        915                 920                 925             


Phe Asp Leu Pro Leu Thr Val Met Pro Ser Val Glu His Glu Lys Pro 
    930                 935                 940                 


Ala Arg Pro Glu Gly Gln Lys Ala Met Asn Trp Lys Glu Ser Phe Gln 
945                 950                 955                 960 


Met Gly Ser Lys Ser Ser Pro Pro Ser Pro Tyr Met Gly Phe Ser Gly 
                965                 970                 975     


Asn Ser Lys Asp Ser Arg Arg Gly Thr Ser Glu Leu Asp Arg Pro Leu 
            980                 985                 990         


Gln Gly Thr Leu Thr Leu Leu Arg  Ser Val Phe Arg Lys  Lys Glu Asn 
        995                 1000                 1005             


Arg Arg  Asn Glu Arg Ala Glu  Val Ser Pro Gln Val  Pro Pro Val 
    1010                 1015                 1020             


Ser Leu  Val Ser Gly Gly Leu  Ser Pro Ala Met Asp  Gly Gln Ala 
    1025                 1030                 1035             


Pro Gly  Ser Pro Pro Ala Leu  Arg Ile Pro Glu Gly  Leu Ala Arg 
    1040                 1045                 1050             


Gly Leu  Gly Ser Arg Leu Glu  Arg Asp Val Trp Ser  Ala Pro Ser 
    1055                 1060                 1065             


Ser Leu  Arg Leu Pro Arg Lys  Ala Ser Arg Ala Pro  Arg Gly Ser 
    1070                 1075                 1080             


Ala Leu  Gly Met Ser Gln Arg  Thr Val Pro Gly Glu  Gln Ala Ser 
    1085                 1090                 1095             


Tyr Gly  Thr Phe Gln Arg Val  Lys Tyr His Thr Leu  Ser Leu Gly 
    1100                 1105                 1110             


Arg Lys  Lys Thr Leu Pro Glu  Ser Ser Phe 
    1115                 1120             


<210> 14
<211> 605
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ala Arg 
1               5                   10                  15      


Tyr Thr Asp Ala His Tyr Ala Lys Ser Gly Tyr Gly Ala Tyr Thr Pro 
            20                  25                  30          


Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Leu Leu Glu Lys Glu Lys 
        35                  40                  45              


Leu Gly Phe Lys Pro Val Pro Thr Ser Ser Phe Leu Thr Arg Pro Arg 
    50                  55                  60                  


Thr Tyr Gly Pro Ser Ser Leu Leu Asp Tyr Asp Arg Gly Arg Pro Leu 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Thr Gly Gly Gly Lys Arg Ala Glu Ser Gln Thr 
                85                  90                  95      


Arg Gly Thr Glu Arg Pro Leu Gly Ser Gly Leu Ser Gly Gly Ser Gly 
            100                 105                 110         


Phe Pro Tyr Gly Val Thr Asn Asn Cys Leu Ser Tyr Leu Pro Ile Asn 
        115                 120                 125             


Ala Tyr Asp Gln Gly Val Thr Leu Thr Gln Lys Leu Asp Ser Gln Ser 
    130                 135                 140                 


Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr Arg 
145                 150                 155                 160 


Ile Asp Pro Arg Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg 
                165                 170                 175     


Lys Glu Leu Cys Thr Leu Gln Gly Leu Tyr Gln Thr Ala Ser Cys Pro 
            180                 185                 190         


Glu Tyr Leu Val Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala 
        195                 200                 205             


Ser Gln Val Pro Ser Gln Ala Pro Pro Ser Arg Val Pro Glu Ile Ile 
    210                 215                 220                 


Ser Pro Thr Tyr Arg Pro Ile Gly Arg Tyr Thr Leu Trp Glu Thr Gly 
225                 230                 235                 240 


Lys Gly Gln Ala Pro Gly Pro Ser Arg Ser Ser Ser Pro Gly Arg Asp 
                245                 250                 255     


Gly Met Asn Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu 
            260                 265                 270         


Gly Asn Thr Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr 
        275                 280                 285             


Arg Glu Leu Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu 
    290                 295                 300                 


His His Gly Ser Asn Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys 
305                 310                 315                 320 


Leu Ile Gln Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro 
                325                 330                 335     


Ser Glu Phe Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly 
            340                 345                 350         


Tyr Asn Gln Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly 
        355                 360                 365             


Leu His Asn Glu Val Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro 
    370                 375                 380                 


Glu Asn Leu Asp His Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp 
385                 390                 395                 400 


Arg Lys Tyr Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val 
                405                 410                 415     


Gly Gln Leu Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser 
            420                 425                 430         


Thr Val Phe Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg 
        435                 440                 445             


Gly Tyr Pro Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys 
    450                 455                 460                 


Glu Asp Val Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg 
465                 470                 475                 480 


Gly Arg Lys Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys 
                485                 490                 495     


Ile Leu Val Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr 
            500                 505                 510         


Ser Lys Leu Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu 
        515                 520                 525             


Arg Glu Phe Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr 
    530                 535                 540                 


Ala Val Ser Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala 
545                 550                 555                 560 


Tyr Cys Arg Ser Pro Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser 
                565                 570                 575     


Ser Val Thr Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr 
            580                 585                 590         


Leu Leu Phe Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
        595                 600                 605 


<210> 15
<211> 814
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Val Lys Asp Pro Thr Lys Ala Leu Pro Glu Lys Ala Lys Arg 
1               5                   10                  15      


Ser Lys Arg Pro Thr Val Pro His Asp Glu Asp Ser Ser Asp Asp Ile 
            20                  25                  30          


Ala Val Gly Leu Thr Cys Gln His Val Ser His Ala Ile Ser Val Asn 
        35                  40                  45              


His Val Lys Arg Ala Ile Ala Glu Asn Leu Trp Ser Val Cys Ser Glu 
    50                  55                  60                  


Cys Leu Lys Glu Arg Arg Phe Tyr Asp Gly Gln Leu Val Leu Thr Ser 
65                  70                  75                  80  


Asp Ile Trp Leu Cys Leu Lys Cys Gly Phe Gln Gly Cys Gly Lys Asn 
                85                  90                  95      


Ser Glu Ser Gln His Ser Leu Lys His Phe Lys Ser Ser Arg Thr Glu 
            100                 105                 110         


Pro His Cys Ile Ile Ile Asn Leu Ser Thr Trp Ile Ile Trp Cys Tyr 
        115                 120                 125             


Glu Cys Asp Glu Lys Leu Ser Thr His Cys Asn Lys Lys Val Leu Ala 
    130                 135                 140                 


Gln Ile Val Asp Phe Leu Gln Lys His Ala Ser Lys Thr Gln Thr Ser 
145                 150                 155                 160 


Ala Phe Ser Arg Ile Met Lys Leu Cys Glu Glu Lys Cys Glu Thr Asp 
                165                 170                 175     


Glu Ile Gln Lys Gly Gly Lys Cys Arg Asn Leu Ser Val Arg Gly Ile 
            180                 185                 190         


Thr Asn Leu Gly Asn Thr Cys Phe Phe Asn Ala Val Met Gln Asn Leu 
        195                 200                 205             


Ala Gln Thr Tyr Thr Leu Thr Asp Leu Met Asn Glu Ile Lys Glu Ser 
    210                 215                 220                 


Ser Thr Lys Leu Lys Ile Phe Pro Ser Ser Asp Ser Gln Leu Asp Pro 
225                 230                 235                 240 


Leu Val Val Glu Leu Ser Arg Pro Gly Pro Leu Thr Ser Ala Leu Phe 
                245                 250                 255     


Leu Phe Leu His Ser Met Lys Glu Thr Glu Lys Gly Pro Leu Ser Pro 
            260                 265                 270         


Lys Val Leu Phe Asn Gln Leu Cys Gln Lys Ala Pro Arg Phe Lys Asp 
        275                 280                 285             


Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu His Tyr Leu Leu Asp Ala 
    290                 295                 300                 


Val Arg Thr Glu Glu Thr Lys Arg Ile Gln Ala Ser Ile Leu Lys Ala 
305                 310                 315                 320 


Phe Asn Asn Pro Thr Thr Lys Thr Ala Asp Asp Glu Thr Arg Lys Lys 
                325                 330                 335     


Val Lys Ala Tyr Gly Lys Glu Gly Val Lys Met Asn Phe Ile Asp Arg 
            340                 345                 350         


Ile Phe Ile Gly Glu Leu Thr Ser Thr Val Met Cys Glu Glu Cys Ala 
        355                 360                 365             


Asn Ile Ser Thr Val Lys Asp Pro Phe Ile Asp Ile Ser Leu Pro Ile 
    370                 375                 380                 


Ile Glu Glu Arg Val Ser Lys Pro Leu Leu Trp Gly Arg Met Asn Lys 
385                 390                 395                 400 


Tyr Arg Ser Leu Arg Glu Thr Asp His Asp Arg Tyr Ser Gly Asn Val 
                405                 410                 415     


Thr Ile Glu Asn Ile His Gln Pro Arg Ala Ala Lys Lys His Ser Ser 
            420                 425                 430         


Ser Lys Asp Lys Ser Gln Leu Ile His Asp Arg Lys Cys Ile Arg Lys 
        435                 440                 445             


Leu Ser Ser Gly Glu Thr Val Thr Tyr Gln Lys Asn Glu Asn Leu Glu 
    450                 455                 460                 


Met Asn Gly Asp Ser Leu Met Phe Ala Ser Leu Met Asn Ser Glu Ser 
465                 470                 475                 480 


Arg Leu Asn Glu Ser Pro Thr Asp Asp Ser Glu Lys Glu Ala Ser His 
                485                 490                 495     


Ser Glu Ser Asn Val Asp Ala Asp Ser Glu Pro Ser Glu Ser Glu Ser 
            500                 505                 510         


Ala Ser Lys Gln Thr Gly Leu Phe Arg Ser Ser Ser Gly Ser Gly Val 
        515                 520                 525             


Gln Pro Asp Gly Pro Leu Tyr Pro Leu Ser Ala Gly Lys Leu Leu Tyr 
    530                 535                 540                 


Thr Lys Glu Thr Asp Ser Gly Asp Lys Glu Met Ala Glu Ala Ile Ser 
545                 550                 555                 560 


Glu Leu Arg Leu Ser Ser Thr Val Thr Gly Asp Gln Asp Phe Asp Arg 
                565                 570                 575     


Glu Asn Gln Pro Leu Asn Ile Ser Asn Asn Leu Cys Phe Leu Glu Gly 
            580                 585                 590         


Lys His Leu Arg Ser Tyr Ser Pro Gln Asn Ala Phe Gln Thr Leu Ser 
        595                 600                 605             


Gln Ser Tyr Ile Thr Thr Ser Lys Glu Cys Ser Ile Gln Ser Cys Leu 
    610                 615                 620                 


Tyr Gln Phe Thr Ser Met Glu Leu Leu Met Gly Asn Asn Lys Leu Leu 
625                 630                 635                 640 


Cys Glu Asn Cys Thr Lys Asn Lys Gln Lys Tyr Gln Glu Glu Thr Ser 
                645                 650                 655     


Phe Ala Glu Lys Lys Val Glu Gly Val Tyr Thr Asn Ala Arg Lys Gln 
            660                 665                 670         


Leu Leu Ile Ser Ala Val Pro Ala Val Leu Ile Leu His Leu Lys Arg 
        675                 680                 685             


Phe His Gln Ala Gly Leu Ser Leu Arg Lys Val Asn Arg His Val Asp 
    690                 695                 700                 


Phe Pro Leu Met Leu Asp Leu Ala Pro Phe Cys Ser Ala Thr Cys Lys 
705                 710                 715                 720 


Asn Ala Ser Val Gly Asp Lys Val Leu Tyr Gly Leu Tyr Gly Ile Val 
                725                 730                 735     


Glu His Ser Gly Ser Met Arg Glu Gly His Tyr Thr Ala Tyr Val Lys 
            740                 745                 750         


Val Arg Thr Pro Ser Arg Lys Leu Ser Glu His Asn Thr Lys Lys Lys 
        755                 760                 765             


Asn Val Pro Gly Leu Lys Ala Ala Asp Asn Glu Ser Ala Gly Gln Trp 
    770                 775                 780                 


Val His Val Ser Asp Thr Tyr Leu Gln Val Val Pro Glu Ser Arg Ala 
785                 790                 795                 800 


Leu Ser Ala Gln Ala Tyr Leu Leu Phe Tyr Glu Arg Val Leu 
                805                 810                 


<210> 16
<211> 1604
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Ala Lys Glu Ser Arg Ile Gly Phe Leu Ser Tyr Glu Glu Ala 
1               5                   10                  15      


Leu Arg Arg Val Thr Asp Val Glu Leu Lys Arg Leu Lys Asp Ala Phe 
            20                  25                  30          


Lys Arg Thr Cys Gly Leu Ser Tyr Tyr Met Gly Gln His Cys Phe Ile 
        35                  40                  45              


Arg Glu Val Leu Gly Asp Gly Val Pro Pro Lys Val Ala Glu Val Ile 
    50                  55                  60                  


Tyr Cys Ser Phe Gly Gly Thr Ser Lys Gly Leu His Phe Asn Asn Leu 
65                  70                  75                  80  


Ile Val Gly Leu Val Leu Leu Thr Arg Gly Lys Asp Glu Glu Lys Ala 
                85                  90                  95      


Lys Tyr Ile Phe Ser Leu Phe Ser Ser Glu Ser Gly Asn Tyr Val Ile 
            100                 105                 110         


Arg Glu Glu Met Glu Arg Met Leu His Val Val Asp Gly Lys Val Pro 
        115                 120                 125             


Asp Thr Leu Arg Lys Cys Phe Ser Glu Gly Glu Lys Val Asn Tyr Glu 
    130                 135                 140                 


Lys Phe Arg Asn Trp Leu Phe Leu Asn Lys Asp Ala Phe Thr Phe Ser 
145                 150                 155                 160 


Arg Trp Leu Leu Ser Gly Gly Val Tyr Val Thr Leu Thr Asp Asp Ser 
                165                 170                 175     


Asp Thr Pro Thr Phe Tyr Gln Thr Leu Ala Gly Val Thr His Leu Glu 
            180                 185                 190         


Glu Ser Asp Ile Ile Asp Leu Glu Lys Arg Tyr Trp Leu Leu Lys Ala 
        195                 200                 205             


Gln Ser Arg Thr Gly Arg Phe Asp Leu Glu Thr Phe Gly Pro Leu Val 
    210                 215                 220                 


Ser Pro Pro Ile Arg Pro Ser Leu Ser Glu Gly Leu Phe Asn Ala Phe 
225                 230                 235                 240 


Asp Glu Asn Arg Asp Asn His Ile Asp Phe Lys Glu Ile Ser Cys Gly 
                245                 250                 255     


Leu Ser Ala Cys Cys Arg Gly Pro Leu Ala Glu Arg Gln Lys Phe Cys 
            260                 265                 270         


Phe Lys Val Phe Asp Val Asp Arg Asp Gly Val Leu Ser Arg Val Glu 
        275                 280                 285             


Leu Arg Asp Met Val Val Ala Leu Leu Glu Val Trp Lys Asp Asn Arg 
    290                 295                 300                 


Thr Asp Asp Ile Pro Glu Leu His Met Asp Leu Ser Asp Ile Val Glu 
305                 310                 315                 320 


Gly Ile Leu Asn Ala His Asp Thr Thr Lys Met Gly His Leu Thr Leu 
                325                 330                 335     


Glu Asp Tyr Gln Ile Trp Ser Val Lys Asn Val Leu Ala Asn Glu Phe 
            340                 345                 350         


Leu Asn Leu Leu Phe Gln Val Cys His Ile Val Leu Gly Leu Arg Pro 
        355                 360                 365             


Ala Thr Pro Glu Glu Glu Gly Gln Ile Ile Arg Gly Trp Leu Glu Arg 
    370                 375                 380                 


Glu Ser Arg Tyr Gly Leu Gln Ala Gly His Asn Trp Phe Ile Ile Ser 
385                 390                 395                 400 


Met Gln Trp Trp Gln Gln Trp Lys Glu Tyr Val Lys Tyr Asp Ala Asn 
                405                 410                 415     


Pro Val Val Ile Glu Pro Ser Ser Val Leu Asn Gly Gly Lys Tyr Ser 
            420                 425                 430         


Phe Gly Thr Ala Ala His Pro Met Glu Gln Val Glu Asp Arg Ile Gly 
        435                 440                 445             


Ser Ser Leu Ser Tyr Val Asn Thr Thr Glu Glu Lys Phe Ser Asp Asn 
    450                 455                 460                 


Ile Ser Thr Ala Ser Glu Ala Ser Glu Thr Ala Gly Ser Gly Phe Leu 
465                 470                 475                 480 


Tyr Ser Ala Thr Pro Gly Ala Asp Val Cys Phe Ala Arg Gln His Asn 
                485                 490                 495     


Thr Ser Asp Asn Asn Asn Gln Cys Leu Leu Gly Ala Asn Gly Asn Ile 
            500                 505                 510         


Leu Leu His Leu Asn Pro Gln Lys Pro Gly Ala Ile Asp Asn Gln Pro 
        515                 520                 525             


Leu Val Thr Gln Glu Pro Val Lys Ala Thr Ser Leu Thr Leu Glu Gly 
    530                 535                 540                 


Gly Arg Leu Lys Arg Thr Pro Gln Leu Ile His Gly Arg Asp Tyr Glu 
545                 550                 555                 560 


Met Val Pro Glu Pro Val Trp Arg Ala Leu Tyr His Trp Tyr Gly Ala 
                565                 570                 575     


Asn Leu Ala Leu Pro Arg Pro Val Ile Lys Asn Ser Lys Thr Asp Ile 
            580                 585                 590         


Pro Glu Leu Glu Leu Phe Pro Arg Tyr Leu Leu Phe Leu Arg Gln Gln 
        595                 600                 605             


Pro Ala Thr Arg Thr Gln Gln Ser Asn Ile Trp Val Asn Met Gly Asn 
    610                 615                 620                 


Val Pro Ser Pro Asn Ala Pro Leu Lys Arg Val Leu Ala Tyr Thr Gly 
625                 630                 635                 640 


Cys Phe Ser Arg Met Gln Thr Ile Lys Glu Ile His Glu Tyr Leu Ser 
                645                 650                 655     


Gln Arg Leu Arg Ile Lys Glu Glu Asp Met Arg Leu Trp Leu Tyr Asn 
            660                 665                 670         


Ser Glu Asn Tyr Leu Thr Leu Leu Asp Asp Glu Asp His Lys Leu Glu 
        675                 680                 685             


Tyr Leu Lys Ile Gln Asp Glu Gln His Leu Val Ile Glu Val Arg Asn 
    690                 695                 700                 


Lys Asp Met Ser Trp Pro Glu Glu Met Ser Phe Ile Ala Asn Ser Ser 
705                 710                 715                 720 


Lys Ile Asp Arg His Lys Val Pro Thr Glu Lys Gly Ala Thr Gly Leu 
                725                 730                 735     


Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ser Ile Gln Cys Val 
            740                 745                 750         


Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe Ile Ser Gly Arg His Leu 
        755                 760                 765             


Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly Met Lys Gly His Met Ala 
    770                 775                 780                 


Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu Trp Ser Gly Thr Gln Lys 
785                 790                 795                 800 


Asn Val Ala Pro Leu Lys Leu Arg Trp Thr Ile Ala Lys Tyr Ala Pro 
                805                 810                 815     


Arg Phe Asn Gly Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe 
            820                 825                 830         


Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val His Glu Lys Pro 
        835                 840                 845             


Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg Pro Asp Trp Glu Val Ala 
    850                 855                 860                 


Ala Glu Ala Trp Asp Asn His Leu Arg Arg Asn Arg Ser Ile Val Val 
865                 870                 875                 880 


Asp Leu Phe His Gly Gln Leu Arg Ser Gln Val Lys Cys Lys Thr Cys 
                885                 890                 895     


Gly His Ile Ser Val Arg Phe Asp Pro Phe Asn Phe Leu Ser Leu Pro 
            900                 905                 910         


Leu Pro Met Asp Ser Tyr Met His Leu Glu Ile Thr Val Ile Lys Leu 
        915                 920                 925             


Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu Arg Leu Asn Met Asp Glu 
    930                 935                 940                 


Lys Tyr Thr Gly Leu Lys Lys Gln Leu Ser Asp Leu Cys Gly Leu Asn 
945                 950                 955                 960 


Ser Glu Gln Ile Leu Leu Ala Glu Val His Gly Ser Asn Ile Lys Asn 
                965                 970                 975     


Phe Pro Gln Asp Asn Gln Lys Val Arg Leu Ser Val Ser Gly Phe Leu 
            980                 985                 990         


Cys Ala Phe Glu Ile Pro Val Pro  Val Ser Pro Ile Ser  Ala Ser Ser 
        995                 1000                 1005             


Pro Thr  Gln Thr Asp Phe Ser  Ser Ser Pro Ser Thr  Asn Glu Met 
    1010                 1015                 1020             


Phe Thr  Leu Thr Thr Asn Gly  Asp Leu Pro Arg Pro  Ile Phe Ile 
    1025                 1030                 1035             


Pro Asn  Gly Met Pro Asn Thr  Val Val Pro Cys Gly  Thr Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Asn Gly Met Val  Asn Gly His Met Pro  Ser Leu Pro 
    1055                 1060                 1065             


Asp Ser  Pro Phe Thr Gly Tyr  Ile Ile Ala Val His  Arg Lys Met 
    1070                 1075                 1080             


Met Arg  Thr Glu Leu Tyr Phe  Leu Ser Ser Gln Lys  Asn Arg Pro 
    1085                 1090                 1095             


Ser Leu  Phe Gly Met Pro Leu  Ile Val Pro Cys Thr  Val His Thr 
    1100                 1105                 1110             


Arg Lys  Lys Asp Leu Tyr Asp  Ala Val Trp Ile Gln  Val Ser Arg 
    1115                 1120                 1125             


Leu Ala  Ser Pro Leu Pro Pro  Gln Glu Ala Ser Asn  His Ala Gln 
    1130                 1135                 1140             


Asp Cys  Asp Asp Ser Met Gly  Tyr Gln Tyr Pro Phe  Thr Leu Arg 
    1145                 1150                 1155             


Val Val  Gln Lys Asp Gly Asn  Ser Cys Ala Trp Cys  Pro Trp Tyr 
    1160                 1165                 1170             


Arg Phe  Cys Arg Gly Cys Lys  Ile Asp Cys Gly Glu  Asp Arg Ala 
    1175                 1180                 1185             


Phe Ile  Gly Asn Ala Tyr Ile  Ala Val Asp Trp Asp  Pro Thr Ala 
    1190                 1195                 1200             


Leu His  Leu Arg Tyr Gln Thr  Ser Gln Glu Arg Val  Val Asp Glu 
    1205                 1210                 1215             


His Glu  Ser Val Glu Gln Ser  Arg Arg Ala Gln Ala  Glu Pro Ile 
    1220                 1225                 1230             


Asn Leu  Asp Ser Cys Leu Arg  Ala Phe Thr Ser Glu  Glu Glu Leu 
    1235                 1240                 1245             


Gly Glu  Asn Glu Met Tyr Tyr  Cys Ser Lys Cys Lys  Thr His Cys 
    1250                 1255                 1260             


Leu Ala  Thr Lys Lys Leu Asp  Leu Trp Arg Leu Pro  Pro Ile Leu 
    1265                 1270                 1275             


Ile Ile  His Leu Lys Arg Phe  Gln Phe Val Asn Gly  Arg Trp Ile 
    1280                 1285                 1290             


Lys Ser  Gln Lys Ile Val Lys  Phe Pro Arg Glu Ser  Phe Asp Pro 
    1295                 1300                 1305             


Ser Ala  Phe Leu Val Pro Arg  Asp Pro Ala Leu Cys  Gln His Lys 
    1310                 1315                 1320             


Pro Leu  Thr Pro Gln Gly Asp  Glu Leu Ser Glu Pro  Arg Ile Leu 
    1325                 1330                 1335             


Ala Arg  Glu Val Lys Lys Val  Asp Ala Gln Ser Ser  Ala Gly Glu 
    1340                 1345                 1350             


Glu Asp  Val Leu Leu Ser Lys  Ser Pro Ser Ser Leu  Ser Ala Asn 
    1355                 1360                 1365             


Ile Ile  Ser Ser Pro Lys Gly  Ser Pro Ser Ser Ser  Arg Lys Ser 
    1370                 1375                 1380             


Gly Thr  Ser Cys Pro Ser Ser  Lys Asn Ser Ser Pro  Asn Ser Ser 
    1385                 1390                 1395             


Pro Arg  Thr Leu Gly Arg Ser  Lys Gly Arg Leu Arg  Leu Pro Gln 
    1400                 1405                 1410             


Ile Gly  Ser Lys Asn Lys Leu  Ser Ser Ser Lys Glu  Asn Leu Asp 
    1415                 1420                 1425             


Ala Ser  Lys Glu Asn Gly Ala  Gly Gln Ile Cys Glu  Leu Ala Asp 
    1430                 1435                 1440             


Ala Leu  Ser Arg Gly His Val  Leu Gly Gly Ser Gln  Pro Glu Leu 
    1445                 1450                 1455             


Val Thr  Pro Gln Asp His Glu  Val Ala Leu Ala Asn  Gly Phe Leu 
    1460                 1465                 1470             


Tyr Glu  His Glu Ala Cys Gly  Asn Gly Tyr Ser Asn  Gly Gln Leu 
    1475                 1480                 1485             


Gly Asn  His Ser Glu Glu Asp  Ser Thr Asp Asp Gln  Arg Glu Asp 
    1490                 1495                 1500             


Thr Arg  Ile Lys Pro Ile Tyr  Asn Leu Tyr Ala Ile  Ser Cys His 
    1505                 1510                 1515             


Ser Gly  Ile Leu Gly Gly Gly  His Tyr Val Thr Tyr  Ala Lys Asn 
    1520                 1525                 1530             


Pro Asn  Cys Lys Trp Tyr Cys  Tyr Asn Asp Ser Ser  Cys Lys Glu 
    1535                 1540                 1545             


Leu His  Pro Asp Glu Ile Asp  Thr Asp Ser Ala Tyr  Ile Leu Phe 
    1550                 1555                 1560             


Tyr Glu  Gln Gln Gly Ile Asp  Tyr Ala Gln Phe Leu  Pro Lys Thr 
    1565                 1570                 1575             


Asp Gly  Lys Lys Met Ala Asp  Thr Ser Ser Met Asp  Glu Asp Phe 
    1580                 1585                 1590             


Glu Ser  Asp Tyr Lys Lys Tyr  Cys Val Leu Gln 
    1595                 1600                 


<210> 17
<211> 398
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ser Glu Asp 
385                 390                 395             


<210> 18
<211> 1324
<212> PRT
<213> Homo sapiens

<400> 18
Met Thr Ile Val Asp Lys Ala Ser Glu Ser Ser Asp Pro Ser Ala Tyr 
1               5                   10                  15      


Gln Asn Gln Pro Gly Ser Ser Glu Ala Val Ser Pro Gly Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Ala Ser Trp Gly Ala Val Ser Ser Leu Asn Asp Val Ser 
        35                  40                  45              


Asn His Thr Leu Ser Leu Gly Pro Val Pro Gly Ala Val Val Tyr Ser 
    50                  55                  60                  


Ser Ser Ser Val Pro Asp Lys Ser Lys Pro Ser Pro Gln Lys Asp Gln 
65                  70                  75                  80  


Ala Leu Gly Asp Gly Ile Ala Pro Pro Gln Lys Val Leu Phe Pro Ser 
                85                  90                  95      


Glu Lys Ile Cys Leu Lys Trp Gln Gln Thr His Arg Val Gly Ala Gly 
            100                 105                 110         


Leu Gln Asn Leu Gly Asn Thr Cys Phe Ala Asn Ala Ala Leu Gln Cys 
        115                 120                 125             


Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser His Glu His 
    130                 135                 140                 


Ser Lys Thr Cys His Ala Glu Gly Phe Cys Met Met Cys Thr Met Gln 
145                 150                 155                 160 


Ala His Ile Thr Gln Ala Leu Ser Asn Pro Gly Asp Val Ile Lys Pro 
                165                 170                 175     


Met Phe Val Ile Asn Glu Met Arg Arg Ile Ala Arg His Phe Arg Phe 
            180                 185                 190         


Gly Asn Gln Glu Asp Ala His Glu Phe Leu Gln Tyr Thr Val Asp Ala 
        195                 200                 205             


Met Gln Lys Ala Cys Leu Asn Gly Ser Asn Lys Leu Asp Arg His Thr 
    210                 215                 220                 


Gln Ala Thr Thr Leu Val Cys Gln Ile Phe Gly Gly Tyr Leu Arg Ser 
225                 230                 235                 240 


Arg Val Lys Cys Leu Asn Cys Lys Gly Val Ser Asp Thr Phe Asp Pro 
                245                 250                 255     


Tyr Leu Asp Ile Thr Leu Glu Ile Lys Ala Ala Gln Ser Val Asn Lys 
            260                 265                 270         


Ala Leu Glu Gln Phe Val Lys Pro Glu Gln Leu Asp Gly Glu Asn Ser 
        275                 280                 285             


Tyr Lys Cys Ser Lys Cys Lys Lys Met Val Pro Ala Ser Lys Arg Phe 
    290                 295                 300                 


Thr Ile His Arg Ser Ser Asn Val Leu Thr Leu Ser Leu Lys Arg Phe 
305                 310                 315                 320 


Ala Asn Phe Thr Gly Gly Lys Ile Ala Lys Asp Val Lys Tyr Pro Glu 
                325                 330                 335     


Tyr Leu Asp Ile Arg Pro Tyr Met Ser Gln Pro Asn Gly Glu Pro Ile 
            340                 345                 350         


Val Tyr Val Leu Tyr Ala Val Leu Val His Thr Gly Phe Asn Cys His 
        355                 360                 365             


Ala Gly His Tyr Phe Cys Tyr Ile Lys Ala Ser Asn Gly Leu Trp Tyr 
    370                 375                 380                 


Gln Met Asn Asp Ser Ile Val Ser Thr Ser Asp Ile Arg Ser Val Leu 
385                 390                 395                 400 


Ser Gln Gln Ala Tyr Val Leu Phe Tyr Ile Arg Ser His Asp Val Lys 
                405                 410                 415     


Asn Gly Gly Glu Leu Thr His Pro Thr His Ser Pro Gly Gln Ser Ser 
            420                 425                 430         


Pro Arg Pro Val Ile Ser Gln Arg Val Val Thr Asn Lys Gln Ala Ala 
        435                 440                 445             


Pro Gly Phe Ile Gly Pro Gln Leu Pro Ser His Met Ile Lys Asn Pro 
    450                 455                 460                 


Pro His Leu Asn Gly Thr Gly Pro Leu Lys Asp Thr Pro Ser Ser Ser 
465                 470                 475                 480 


Met Ser Ser Pro Asn Gly Asn Ser Ser Val Asn Arg Ala Ser Pro Val 
                485                 490                 495     


Asn Ala Ser Ala Ser Val Gln Asn Trp Ser Val Asn Arg Ser Ser Val 
            500                 505                 510         


Ile Pro Glu His Pro Lys Lys Gln Lys Ile Thr Ile Ser Ile His Asn 
        515                 520                 525             


Lys Leu Pro Val Arg Gln Cys Gln Ser Gln Pro Asn Leu His Ser Asn 
    530                 535                 540                 


Ser Leu Glu Asn Pro Thr Lys Pro Val Pro Ser Ser Thr Ile Thr Asn 
545                 550                 555                 560 


Ser Ala Val Gln Ser Thr Ser Asn Ala Ser Thr Met Ser Val Ser Ser 
                565                 570                 575     


Lys Val Thr Lys Pro Ile Pro Arg Ser Glu Ser Cys Ser Gln Pro Val 
            580                 585                 590         


Met Asn Gly Lys Ser Lys Leu Asn Ser Ser Val Leu Val Pro Tyr Gly 
        595                 600                 605             


Ala Glu Ser Ser Glu Asp Ser Asp Glu Glu Ser Lys Gly Leu Gly Lys 
    610                 615                 620                 


Glu Asn Gly Ile Gly Thr Ile Val Ser Ser His Ser Pro Gly Gln Asp 
625                 630                 635                 640 


Ala Glu Asp Glu Glu Ala Thr Pro His Glu Leu Gln Glu Pro Met Thr 
                645                 650                 655     


Leu Asn Gly Ala Asn Ser Ala Asp Ser Asp Ser Asp Pro Lys Glu Asn 
            660                 665                 670         


Gly Leu Ala Pro Asp Gly Ala Ser Cys Gln Gly Gln Pro Ala Leu His 
        675                 680                 685             


Ser Glu Asn Pro Phe Ala Lys Ala Asn Gly Leu Pro Gly Lys Leu Met 
    690                 695                 700                 


Pro Ala Pro Leu Leu Ser Leu Pro Glu Asp Lys Ile Leu Glu Thr Phe 
705                 710                 715                 720 


Arg Leu Ser Asn Lys Leu Lys Gly Ser Thr Asp Glu Met Ser Ala Pro 
                725                 730                 735     


Gly Ala Glu Arg Gly Pro Pro Glu Asp Arg Asp Ala Glu Pro Gln Pro 
            740                 745                 750         


Gly Ser Pro Ala Ala Glu Ser Leu Glu Glu Pro Asp Ala Ala Ala Gly 
        755                 760                 765             


Leu Ser Ser Thr Lys Lys Ala Pro Pro Pro Arg Asp Pro Gly Thr Pro 
    770                 775                 780                 


Ala Thr Lys Glu Gly Ala Trp Glu Ala Met Ala Val Ala Pro Glu Glu 
785                 790                 795                 800 


Pro Pro Pro Ser Ala Gly Glu Asp Ile Val Gly Asp Thr Ala Pro Pro 
                805                 810                 815     


Asp Leu Cys Asp Pro Gly Ser Leu Thr Gly Asp Ala Ser Pro Leu Ser 
            820                 825                 830         


Gln Asp Ala Lys Gly Met Ile Ala Glu Gly Pro Arg Asp Ser Ala Leu 
        835                 840                 845             


Ala Glu Ala Pro Glu Gly Leu Ser Pro Ala Pro Pro Ala Arg Ser Glu 
    850                 855                 860                 


Glu Pro Cys Glu Gln Pro Leu Leu Val His Pro Ser Gly Asp His Ala 
865                 870                 875                 880 


Arg Asp Ala Gln Asp Pro Ser Gln Ser Leu Gly Ala Pro Glu Ala Ala 
                885                 890                 895     


Glu Arg Pro Pro Ala Pro Val Leu Asp Met Ala Pro Ala Gly His Pro 
            900                 905                 910         


Glu Gly Asp Ala Glu Pro Ser Pro Gly Glu Arg Val Glu Asp Ala Ala 
        915                 920                 925             


Ala Pro Lys Ala Pro Gly Pro Ser Pro Ala Lys Glu Lys Ile Gly Ser 
    930                 935                 940                 


Leu Arg Lys Val Asp Arg Gly His Tyr Arg Ser Arg Arg Glu Arg Ser 
945                 950                 955                 960 


Ser Ser Gly Glu Pro Ala Arg Glu Ser Arg Ser Lys Thr Glu Gly His 
                965                 970                 975     


Arg His Arg Arg Arg Arg Thr Cys Pro Arg Glu Arg Asp Arg Gln Asp 
            980                 985                 990         


Arg His Ala Pro Glu His His Pro  Gly His Gly Asp Arg  Leu Ser Pro 
        995                 1000                 1005             


Gly Glu  Arg Arg Ser Leu Gly  Arg Cys Ser His His  His Ser Arg 
    1010                 1015                 1020             


His Arg  Ser Gly Val Glu Leu  Asp Trp Val Arg His  His Tyr Thr 
    1025                 1030                 1035             


Glu Gly  Glu Arg Gly Trp Gly  Arg Glu Lys Phe Tyr  Pro Asp Arg 
    1040                 1045                 1050             


Pro Arg  Trp Asp Arg Cys Arg  Tyr Tyr His Asp Arg  Tyr Ala Leu 
    1055                 1060                 1065             


Tyr Ala  Ala Arg Asp Trp Lys  Pro Phe His Gly Gly  Arg Glu His 
    1070                 1075                 1080             


Glu Arg  Ala Gly Leu His Glu  Arg Pro His Lys Asp  His Asn Arg 
    1085                 1090                 1095             


Gly Arg  Arg Gly Cys Glu Pro  Ala Arg Glu Arg Glu  Arg His Arg 
    1100                 1105                 1110             


Pro Ser  Ser Pro Arg Ala Gly  Ala Pro His Ala Leu  Ala Pro His 
    1115                 1120                 1125             


Pro Asp  Arg Phe Ser His Asp  Arg Thr Ala Leu Val  Ala Gly Asp 
    1130                 1135                 1140             


Asn Cys  Asn Leu Ser Asp Arg  Phe His Glu His Glu  Asn Gly Lys 
    1145                 1150                 1155             


Ser Arg  Lys Arg Arg His Asp  Ser Val Glu Asn Ser  Asp Ser His 
    1160                 1165                 1170             


Val Glu  Lys Lys Ala Arg Arg  Ser Glu Gln Lys Asp  Pro Leu Glu 
    1175                 1180                 1185             


Glu Pro  Lys Ala Lys Lys His  Lys Lys Ser Lys Lys  Lys Lys Lys 
    1190                 1195                 1200             


Ser Lys  Asp Lys His Arg Asp  Arg Asp Ser Arg His  Gln Gln Asp 
    1205                 1210                 1215             


Ser Asp  Leu Ser Ala Ala Cys  Ser Asp Ala Asp Leu  His Arg His 
    1220                 1225                 1230             


Lys Lys  Lys Lys Lys Lys Lys  Lys Arg His Ser Arg  Lys Ser Glu 
    1235                 1240                 1245             


Asp Phe  Val Lys Asp Ser Glu  Leu His Leu Pro Arg  Val Thr Ser 
    1250                 1255                 1260             


Leu Glu  Thr Val Ala Gln Phe  Arg Arg Ala Gln Gly  Gly Phe Pro 
    1265                 1270                 1275             


Leu Ser  Gly Gly Pro Pro Leu  Glu Gly Val Gly Pro  Phe Arg Glu 
    1280                 1285                 1290             


Lys Thr  Lys His Leu Arg Met  Glu Ser Arg Asp Asp  Arg Cys Arg 
    1295                 1300                 1305             


Leu Phe  Glu Tyr Gly Gln Gly  Lys Arg Arg Tyr Leu  Glu Leu Gly 
    1310                 1315                 1320             


Arg 
    


<210> 19
<211> 530
<212> PRT
<213> Homo sapiens

<400> 19
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Asp Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Leu Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Ser Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Phe Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Lys Ile Gly Asn Thr Phe Tyr Val Asn Val Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ser Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


Asp Ser Gln Thr Cys His Leu His Lys Cys Cys Met Phe Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Val Leu Ala Ala Gly Phe His Arg Gly Glu Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Leu Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Ala Tyr Trp Arg Ser Gln Ile Lys Tyr Leu 
        195                 200                 205             


His Cys His Gly Val Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Lys Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Lys Ala Pro Ala Ser Lys Thr Leu Thr Leu Pro Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Lys Cys Arg Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Gly Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Lys Pro Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Ser Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Asn Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 20
<211> 530
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 21
<211> 863
<212> PRT
<213> Homo sapiens

<400> 21
Met Gln Arg Arg Gly Ala Leu Phe Gly Met Pro Gly Gly Ser Gly Gly 
1               5                   10                  15      


Arg Lys Met Ala Ala Gly Asp Ile Gly Glu Leu Leu Val Pro His Met 
            20                  25                  30          


Pro Thr Ile Arg Val Pro Arg Ser Gly Asp Arg Val Tyr Lys Asn Glu 
        35                  40                  45              


Cys Ala Phe Ser Tyr Asp Ser Pro Asn Ser Glu Gly Gly Leu Tyr Val 
    50                  55                  60                  


Cys Met Asn Thr Phe Leu Ala Phe Gly Arg Glu His Val Glu Arg His 
65                  70                  75                  80  


Phe Arg Lys Thr Gly Gln Ser Val Tyr Met His Leu Lys Arg His Val 
                85                  90                  95      


Arg Glu Lys Val Arg Gly Ala Ser Gly Gly Ala Leu Pro Lys Arg Arg 
            100                 105                 110         


Asn Ser Lys Ile Phe Leu Asp Leu Asp Thr Asp Asp Asp Leu Asn Ser 
        115                 120                 125             


Asp Asp Tyr Glu Tyr Glu Asp Glu Ala Lys Leu Val Ile Phe Pro Asp 
    130                 135                 140                 


His Tyr Glu Ile Ala Leu Pro Asn Ile Glu Glu Leu Pro Ala Leu Val 
145                 150                 155                 160 


Thr Ile Ala Cys Asp Ala Val Leu Ser Ser Lys Ser Pro Tyr Arg Lys 
                165                 170                 175     


Gln Asp Pro Asp Thr Trp Glu Asn Glu Leu Pro Val Ser Lys Tyr Ala 
            180                 185                 190         


Asn Asn Leu Thr Gln Leu Asp Asn Gly Val Arg Ile Pro Pro Ser Gly 
        195                 200                 205             


Trp Lys Cys Ala Arg Cys Asp Leu Arg Glu Asn Leu Trp Leu Asn Leu 
    210                 215                 220                 


Thr Asp Gly Ser Val Leu Cys Gly Lys Trp Phe Phe Asp Ser Ser Gly 
225                 230                 235                 240 


Gly Asn Gly His Ala Leu Glu His Tyr Arg Asp Met Gly Tyr Pro Leu 
                245                 250                 255     


Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala Asp Val Tyr Ser 
            260                 265                 270         


Phe Gln Glu Glu Glu Pro Val Leu Asp Pro His Leu Ala Lys His Leu 
        275                 280                 285             


Ala His Phe Gly Ile Asp Met Leu His Met His Gly Thr Glu Asn Gly 
    290                 295                 300                 


Leu Gln Asp Asn Asp Ile Lys Leu Arg Val Ser Glu Trp Glu Val Ile 
305                 310                 315                 320 


Gln Glu Ser Gly Thr Lys Leu Lys Pro Met Tyr Gly Pro Gly Tyr Thr 
                325                 330                 335     


Gly Leu Lys Asn Leu Gly Asn Ser Cys Tyr Leu Ser Ser Val Met Gln 
            340                 345                 350         


Ala Ile Phe Ser Ile Pro Glu Phe Gln Arg Ala Tyr Val Gly Asn Leu 
        355                 360                 365             


Pro Arg Ile Phe Asp Tyr Ser Pro Leu Asp Pro Thr Gln Asp Phe Asn 
    370                 375                 380                 


Thr Gln Met Thr Lys Leu Gly His Gly Leu Leu Ser Gly Gln Tyr Ser 
385                 390                 395                 400 


Lys Pro Pro Val Lys Ser Glu Leu Ile Glu Gln Val Met Lys Glu Glu 
                405                 410                 415     


His Lys Pro Gln Gln Asn Gly Ile Ser Pro Arg Met Phe Lys Ala Phe 
            420                 425                 430         


Val Ser Lys Ser His Pro Glu Phe Ser Ser Asn Arg Gln Gln Asp Ala 
        435                 440                 445             


Gln Glu Phe Phe Leu His Leu Val Asn Leu Val Glu Arg Asn Arg Ile 
    450                 455                 460                 


Gly Ser Glu Asn Pro Ser Asp Val Phe Arg Phe Leu Val Glu Glu Arg 
465                 470                 475                 480 


Ile Gln Cys Cys Gln Thr Arg Lys Val Arg Tyr Thr Glu Arg Val Asp 
                485                 490                 495     


Tyr Leu Met Gln Leu Pro Val Ala Met Glu Ala Ala Thr Asn Lys Asp 
            500                 505                 510         


Glu Leu Ile Ala Tyr Glu Leu Thr Arg Arg Glu Ala Glu Ala Asn Arg 
        515                 520                 525             


Arg Pro Leu Pro Glu Leu Val Arg Ala Lys Ile Pro Phe Ser Ala Cys 
    530                 535                 540                 


Leu Gln Ala Phe Ser Glu Pro Glu Asn Val Asp Asp Phe Trp Ser Ser 
545                 550                 555                 560 


Ala Leu Gln Ala Lys Ser Ala Gly Val Lys Thr Ser Arg Phe Ala Ser 
                565                 570                 575     


Phe Pro Glu Tyr Leu Val Val Gln Ile Lys Lys Phe Thr Phe Gly Leu 
            580                 585                 590         


Asp Trp Val Pro Lys Lys Phe Asp Val Ser Ile Asp Met Pro Asp Leu 
        595                 600                 605             


Leu Asp Ile Asn His Leu Arg Ala Arg Gly Leu Gln Pro Gly Glu Glu 
    610                 615                 620                 


Glu Leu Pro Asp Ile Ser Pro Pro Ile Val Ile Pro Asp Asp Ser Lys 
625                 630                 635                 640 


Asp Arg Leu Met Asn Gln Leu Ile Asp Pro Ser Asp Ile Asp Glu Ser 
                645                 650                 655     


Ser Val Met Gln Leu Ala Glu Met Gly Phe Pro Leu Glu Ala Cys Arg 
            660                 665                 670         


Lys Ala Val Tyr Phe Thr Gly Asn Met Gly Ala Glu Val Ala Phe Asn 
        675                 680                 685             


Trp Ile Ile Val His Met Glu Glu Pro Asp Phe Ala Glu Pro Leu Thr 
    690                 695                 700                 


Met Pro Gly Tyr Gly Gly Ala Ala Ser Ala Gly Ala Ser Val Phe Gly 
705                 710                 715                 720 


Ala Ser Gly Leu Asp Asn Gln Pro Pro Glu Glu Ile Val Ala Ile Ile 
                725                 730                 735     


Thr Ser Met Gly Phe Gln Arg Asn Gln Ala Ile Gln Ala Leu Arg Ala 
            740                 745                 750         


Thr Asn Asn Asn Leu Glu Arg Ala Leu Asp Trp Ile Phe Ser His Pro 
        755                 760                 765             


Glu Phe Glu Glu Asp Ser Asp Phe Val Ile Glu Met Glu Asn Asn Ala 
    770                 775                 780                 


Asn Ala Asn Ile Ile Ser Glu Ala Lys Pro Glu Gly Pro Arg Val Lys 
785                 790                 795                 800 


Asp Gly Ser Gly Thr Tyr Glu Leu Phe Ala Phe Ile Ser His Met Gly 
                805                 810                 815     


Thr Ser Thr Met Ser Gly His Tyr Ile Cys His Ile Lys Lys Glu Gly 
            820                 825                 830         


Arg Trp Val Ile Tyr Asn Asp His Lys Val Cys Ala Ser Glu Arg Pro 
        835                 840                 845             


Pro Lys Asp Leu Gly Tyr Met Tyr Phe Tyr Arg Arg Ile Pro Ser 
    850                 855                 860             


<210> 22
<211> 963
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Val Ala Pro Arg Leu Phe Gly Gly Leu Cys Phe Arg Phe Arg 
1               5                   10                  15      


Asp Gln Asn Pro Glu Val Ala Val Glu Gly Arg Leu Pro Ile Ser His 
            20                  25                  30          


Ser Cys Val Gly Cys Arg Arg Glu Arg Thr Ala Met Ala Thr Val Ala 
        35                  40                  45              


Ala Asn Pro Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Val 
    50                  55                  60                  


Thr Glu Asp Arg Glu Pro Gln His Glu Glu Leu Pro Gly Leu Asp Ser 
65                  70                  75                  80  


Gln Trp Arg Gln Ile Glu Asn Gly Glu Ser Gly Arg Glu Arg Pro Leu 
                85                  90                  95      


Arg Ala Gly Glu Ser Trp Phe Leu Val Glu Lys His Trp Tyr Lys Gln 
            100                 105                 110         


Trp Glu Ala Tyr Val Gln Gly Gly Asp Gln Asp Ser Ser Thr Phe Pro 
        115                 120                 125             


Gly Cys Ile Asn Asn Ala Thr Leu Phe Gln Asp Glu Ile Asn Trp Arg 
    130                 135                 140                 


Leu Lys Glu Gly Leu Val Glu Gly Glu Asp Tyr Val Leu Leu Pro Ala 
145                 150                 155                 160 


Ala Ala Trp His Tyr Leu Val Ser Trp Tyr Gly Leu Glu His Gly Gln 
                165                 170                 175     


Pro Pro Ile Glu Arg Lys Val Ile Glu Leu Pro Asn Ile Gln Lys Val 
            180                 185                 190         


Glu Val Tyr Pro Val Glu Leu Leu Leu Val Arg His Asn Asp Leu Gly 
        195                 200                 205             


Lys Ser His Thr Val Gln Phe Ser His Thr Asp Ser Ile Gly Leu Val 
    210                 215                 220                 


Leu Arg Thr Ala Arg Glu Arg Phe Leu Val Glu Pro Gln Glu Asp Thr 
225                 230                 235                 240 


Arg Leu Trp Ala Lys Asn Ser Glu Gly Ser Leu Asp Arg Leu Tyr Asp 
                245                 250                 255     


Thr His Ile Thr Val Leu Asp Ala Ala Leu Glu Thr Gly Gln Leu Ile 
            260                 265                 270         


Ile Met Glu Thr Arg Lys Lys Asp Gly Thr Trp Pro Ser Ala Gln Leu 
        275                 280                 285             


His Val Met Asn Asn Asn Met Ser Glu Glu Asp Glu Asp Phe Lys Gly 
    290                 295                 300                 


Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys Phe Met 
305                 310                 315                 320 


Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr Glu Tyr 
                325                 330                 335     


Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn Pro Leu 
            340                 345                 350         


Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val Lys Gln 
        355                 360                 365             


Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe Lys Asn 
    370                 375                 380                 


Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln His Asp 
385                 390                 395                 400 


Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu Asp Leu 
                405                 410                 415     


Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala Ala Gly 
            420                 425                 430         


Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His Lys Arg 
        435                 440                 445             


Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe Lys Ser 
    450                 455                 460                 


Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe Asp Pro 
465                 470                 475                 480 


Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg Val Leu 
                485                 490                 495     


Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu Gln His 
            500                 505                 510         


Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys Val Ala 
        515                 520                 525             


Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val Ala Asp 
    530                 535                 540                 


Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu Pro Leu 
545                 550                 555                 560 


Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val Ser Gly 
                565                 570                 575     


Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val Pro Val 
            580                 585                 590         


Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser Tyr Tyr 
        595                 600                 605             


Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro Arg Asp 
    610                 615                 620                 


Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg Leu Ser 
625                 630                 635                 640 


Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly Asp Glu 
                645                 650                 655     


Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro Ser Thr 
            660                 665                 670         


Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro Ser Ser 
        675                 680                 685             


Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu Gly Thr 
    690                 695                 700                 


Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr Leu Gln 
705                 710                 715                 720 


Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro Glu Glu 
                725                 730                 735     


Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu Met Lys 
            740                 745                 750         


Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys His Asp 
        755                 760                 765             


Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln Glu Cys 
    770                 775                 780                 


Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn Pro Trp 
785                 790                 795                 800 


Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys Leu Asp 
                805                 810                 815     


Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg Phe Ser 
            820                 825                 830         


Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu Phe Pro 
        835                 840                 845             


Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln Asn Glu 
    850                 855                 860                 


Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser Asn His 
865                 870                 875                 880 


Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys Asn Lys 
                885                 890                 895     


Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser Pro Val 
            900                 905                 910         


Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe Tyr Gln 
        915                 920                 925             


Arg Gln Asp Val Ala Arg Arg Leu Leu Ser Pro Ala Gly Ser Ser Gly 
    930                 935                 940                 


Ala Pro Ala Ser Pro Ala Cys Ser Ser Pro Pro Ser Ser Glu Phe Met 
945                 950                 955                 960 


Asp Val Asn 
            


<210> 23
<211> 530
<212> PRT
<213> Homo sapiens

<400> 23
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Cys Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Val Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Ile Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Gly Lys Val Glu Gly Thr Leu Pro Pro Asn Ala Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ala Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 24
<211> 494
<212> PRT
<213> Homo sapiens

<400> 24
Met Pro Leu Tyr Ser Val Thr Val Lys Trp Gly Lys Glu Lys Phe Glu 
1               5                   10                  15      


Gly Val Glu Leu Asn Thr Asp Glu Pro Pro Met Val Phe Lys Ala Gln 
            20                  25                  30          


Leu Phe Ala Leu Thr Gly Val Gln Pro Ala Arg Gln Lys Val Met Val 
        35                  40                  45              


Lys Gly Gly Thr Leu Lys Asp Asp Asp Trp Gly Asn Ile Lys Ile Lys 
    50                  55                  60                  


Asn Gly Met Thr Leu Leu Met Met Gly Ser Ala Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Glu Pro Ser Ala Lys Thr Val Phe Val Glu Asp Met Thr Glu Glu Gln 
                85                  90                  95      


Leu Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn 
            100                 105                 110         


Thr Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu 
        115                 120                 125             


Leu Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly 
    130                 135                 140                 


Glu Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe 
145                 150                 155                 160 


Asp Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu 
                165                 170                 175     


Gln Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln 
            180                 185                 190         


Gly Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met 
        195                 200                 205             


Arg Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys 
    210                 215                 220                 


Glu Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys 
225                 230                 235                 240 


Ser Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys 
                245                 250                 255     


Cys Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln 
            260                 265                 270         


Leu Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr 
        275                 280                 285             


Gly Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr 
    290                 295                 300                 


Leu Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu 
305                 310                 315                 320 


Pro Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys 
                325                 330                 335     


Glu Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met 
            340                 345                 350         


Leu Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val 
        355                 360                 365             


Ser Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln 
    370                 375                 380                 


Gln Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys 
385                 390                 395                 400 


Tyr Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly 
                405                 410                 415     


Tyr Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser 
            420                 425                 430         


Ser Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile 
        435                 440                 445             


Lys Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu 
    450                 455                 460                 


Arg Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr 
465                 470                 475                 480 


Gly Pro Arg Arg Val Glu Ile Met Glu Glu Glu Ser Glu Gln 
                485                 490                 


<210> 25
<211> 963
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Glu Gly Gly Gly Cys Arg Glu Arg Pro Asp Ala Glu Thr Gln 
1               5                   10                  15      


Lys Ser Glu Leu Gly Pro Leu Met Arg Thr Thr Leu Gln Arg Gly Ala 
            20                  25                  30          


Gln Trp Tyr Leu Ile Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr 
        35                  40                  45              


Val Gly Phe Asp Ser Trp Asp Met Tyr Asn Val Gly Glu His Asn Leu 
    50                  55                  60                  


Phe Pro Gly Pro Ile Asp Asn Ser Gly Leu Phe Ser Asp Pro Glu Ser 
65                  70                  75                  80  


Gln Thr Leu Lys Glu His Leu Ile Asp Glu Leu Asp Tyr Val Leu Val 
                85                  90                  95      


Pro Thr Glu Ala Trp Asn Lys Leu Leu Asn Trp Tyr Gly Cys Val Glu 
            100                 105                 110         


Gly Gln Gln Pro Ile Val Arg Lys Val Val Glu His Gly Leu Phe Val 
        115                 120                 125             


Lys His Cys Lys Val Glu Val Tyr Leu Leu Glu Leu Lys Leu Cys Glu 
    130                 135                 140                 


Asn Ser Asp Pro Thr Asn Val Leu Ser Cys His Phe Ser Lys Ala Asp 
145                 150                 155                 160 


Thr Ile Ala Thr Ile Glu Lys Glu Met Arg Lys Leu Phe Asn Ile Pro 
                165                 170                 175     


Ala Glu Arg Glu Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Tyr 
            180                 185                 190         


Glu Gln Leu Ser Lys Leu Asp Asn Thr Val Gln Asp Ala Gly Leu Tyr 
        195                 200                 205             


Gln Gly Gln Val Leu Val Ile Glu Pro Gln Asn Glu Asp Gly Thr Trp 
    210                 215                 220                 


Pro Arg Gln Thr Leu Gln Ser Lys Ser Ser Thr Ala Pro Ser Arg Asn 
225                 230                 235                 240 


Phe Thr Thr Ser Pro Lys Ser Ser Ala Ser Pro Tyr Ser Ser Val Ser 
                245                 250                 255     


Ala Ser Leu Ile Ala Asn Gly Asp Ser Thr Ser Thr Cys Gly Met His 
            260                 265                 270         


Ser Ser Gly Val Ser Arg Gly Gly Ser Gly Phe Ser Ala Ser Tyr Asn 
        275                 280                 285             


Cys Gln Glu Pro Pro Ser Ser His Ile Gln Pro Gly Leu Cys Gly Leu 
    290                 295                 300                 


Gly Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Leu Gln Cys Leu 
305                 310                 315                 320 


Ser Asn Thr Ala Pro Leu Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu 
                325                 330                 335     


Ala Glu Ile Asn Arg Asp Asn Pro Leu Gly Met Lys Gly Glu Ile Ala 
            340                 345                 350         


Glu Ala Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly Arg Asp Ala 
        355                 360                 365             


His Val Ala Pro Arg Met Phe Lys Thr Gln Val Gly Arg Phe Ala Pro 
    370                 375                 380                 


Gln Phe Ser Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe 
385                 390                 395                 400 


Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val Lys Lys Lys Pro 
                405                 410                 415     


Tyr Leu Glu Leu Lys Asp Ala Asn Gly Arg Pro Asp Ala Val Val Ala 
            420                 425                 430         


Lys Glu Ala Trp Glu Asn His Arg Leu Arg Asn Asp Ser Val Ile Val 
        435                 440                 445             


Asp Thr Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys Pro Glu Cys 
    450                 455                 460                 


Ala Lys Val Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro 
465                 470                 475                 480 


Leu Pro Leu Lys Lys Asp Arg Val Met Glu Val Phe Leu Val Pro Ala 
                485                 490                 495     


Asp Pro His Cys Arg Pro Thr Gln Tyr Arg Val Thr Val Pro Leu Met 
            500                 505                 510         


Gly Ala Val Ser Asp Leu Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile 
        515                 520                 525             


Ala Ala Glu Asn Met Val Val Ala Asp Val Tyr Asn His Arg Phe His 
    530                 535                 540                 


Lys Ile Phe Gln Met Asp Glu Gly Leu Asn His Ile Met Pro Arg Asp 
545                 550                 555                 560 


Asp Ile Phe Val Tyr Glu Val Cys Ser Thr Ser Val Asp Gly Ser Glu 
                565                 570                 575     


Cys Val Thr Leu Pro Val Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser 
            580                 585                 590         


Ser Thr Ser Ser Ala Ser Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser 
        595                 600                 605             


Val Pro Lys His Lys Leu Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys 
    610                 615                 620                 


Asp Arg Ile Ser Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe Gly 
625                 630                 635                 640 


Ser Ser Pro Leu Glu Pro Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys 
                645                 650                 655     


Glu Gly Glu Asp Glu Glu Glu Met Glu His Gln Glu Glu Gly Lys Glu 
            660                 665                 670         


Gln Leu Ser Glu Thr Glu Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp 
        675                 680                 685             


Pro Ser Glu Thr Thr Gln Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys 
    690                 695                 700                 


Arg Leu Phe Thr Phe Ser Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile 
705                 710                 715                 720 


Asn Ser Leu Ala Ala Asp Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser 
                725                 730                 735     


Thr Leu Ala Met Asp Trp Asp Ser Glu Thr Arg Arg Leu Tyr Tyr Asp 
            740                 745                 750         


Glu Gln Glu Ser Glu Ala Tyr Glu Lys His Val Ser Met Leu Gln Pro 
        755                 760                 765             


Gln Lys Lys Lys Lys Thr Thr Val Ala Leu Arg Asp Cys Ile Glu Leu 
    770                 775                 780                 


Phe Thr Thr Met Glu Thr Leu Gly Glu His Asp Pro Trp Tyr Cys Pro 
785                 790                 795                 800 


Asn Cys Lys Lys His Gln Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser 
                805                 810                 815     


Leu Pro Lys Ile Leu Val Val His Leu Lys Arg Phe Ser Tyr Asn Arg 
            820                 825                 830         


Tyr Trp Arg Asp Lys Leu Asp Thr Val Val Glu Phe Pro Ile Arg Gly 
        835                 840                 845             


Leu Asn Met Ser Glu Phe Val Cys Asn Leu Ser Ala Arg Pro Tyr Val 
    850                 855                 860                 


Tyr Asp Leu Ile Ala Val Ser Asn His Tyr Gly Ala Met Gly Val Gly 
865                 870                 875                 880 


His Tyr Thr Ala Tyr Ala Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr 
                885                 890                 895     


Phe Asp Asp Ser Asn Val Ser Leu Ala Ser Glu Asp Gln Ile Val Thr 
            900                 905                 910         


Lys Ala Ala Tyr Val Leu Phe Tyr Gln Arg Arg Asp Asp Glu Phe Tyr 
        915                 920                 925             


Lys Thr Pro Ser Leu Ser Ser Ser Gly Ser Ser Asp Gly Gly Thr Arg 
    930                 935                 940                 


Pro Ser Ser Ser Gln Gln Gly Phe Gly Asp Asp Glu Ala Cys Ser Met 
945                 950                 955                 960 


Asp Thr Asn 
            


<210> 26
<211> 913
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ala Leu Phe Leu Arg Gly Phe Val Gln Ile Gly Asn Cys Lys 
1               5                   10                  15      


Thr Gly Ile Ser Lys Ser Lys Glu Ala Phe Ile Glu Ala Val Glu Arg 
            20                  25                  30          


Lys Lys Lys Asp Arg Leu Val Leu Tyr Phe Lys Ser Gly Lys Tyr Ser 
        35                  40                  45              


Thr Phe Arg Leu Ser Asp Asn Ile Gln Asn Val Val Leu Lys Ser Tyr 
    50                  55                  60                  


Arg Gly Asn Gln Asn His Leu His Leu Thr Leu Gln Asn Asn Asn Gly 
65                  70                  75                  80  


Leu Phe Ile Glu Gly Leu Ser Ser Thr Asp Ala Glu Gln Leu Lys Ile 
                85                  90                  95      


Phe Leu Asp Arg Val His Gln Asn Glu Val Gln Pro Pro Val Arg Pro 
            100                 105                 110         


Gly Lys Gly Gly Ser Val Phe Ser Ser Thr Thr Gln Lys Glu Ile Asn 
        115                 120                 125             


Lys Thr Ser Phe His Lys Val Asp Glu Lys Ser Ser Ser Lys Ser Phe 
    130                 135                 140                 


Glu Ile Ala Lys Gly Ser Gly Thr Gly Val Leu Gln Arg Met Pro Leu 
145                 150                 155                 160 


Leu Thr Ser Lys Leu Thr Leu Thr Cys Gly Glu Leu Ser Glu Asn Gln 
                165                 170                 175     


His Lys Lys Arg Lys Arg Met Leu Ser Ser Ser Ser Glu Met Asn Glu 
            180                 185                 190         


Glu Phe Leu Lys Glu Asn Asn Ser Val Glu Tyr Lys Lys Ser Lys Ala 
        195                 200                 205             


Asp Cys Ser Arg Cys Val Ser Tyr Asn Arg Glu Lys Gln Leu Lys Leu 
    210                 215                 220                 


Lys Glu Leu Glu Glu Asn Lys Lys Leu Glu Cys Glu Ser Ser Cys Ile 
225                 230                 235                 240 


Met Asn Ala Thr Gly Asn Pro Tyr Leu Asp Asp Ile Gly Leu Leu Gln 
                245                 250                 255     


Ala Leu Thr Glu Lys Met Val Leu Val Phe Leu Leu Gln Gln Gly Tyr 
            260                 265                 270         


Ser Asp Gly Tyr Thr Lys Trp Asp Lys Leu Lys Leu Phe Phe Glu Leu 
        275                 280                 285             


Phe Pro Glu Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys 
    290                 295                 300                 


Tyr Met Asn Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala 
305                 310                 315                 320 


Asp Asp Leu Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn 
                325                 330                 335     


Ala Leu Thr Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr 
            340                 345                 350         


Asn Ile Glu Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile 
        355                 360                 365             


Ser Ala Ala Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His 
    370                 375                 380                 


Glu Phe Leu Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys 
385                 390                 395                 400 


Leu Asn Thr Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe 
                405                 410                 415     


Pro Lys Gln Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys 
            420                 425                 430         


Pro Val Ile Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys 
        435                 440                 445             


Lys Ala Cys Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu 
    450                 455                 460                 


Ser Ile Asn Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln 
465                 470                 475                 480 


Ser Thr Phe Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys 
                485                 490                 495     


Ala Lys Cys Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg 
            500                 505                 510         


Leu Pro Arg Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu 
        515                 520                 525             


Phe Cys Ala Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr 
    530                 535                 540                 


Leu Lys Val Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro 
545                 550                 555                 560 


Leu Ser Glu Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile 
                565                 570                 575     


Arg Lys Met Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys 
            580                 585                 590         


Glu Ser Lys Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser 
        595                 600                 605             


Glu Gln Lys Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln 
    610                 615                 620                 


Gln Gln Lys Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser 
625                 630                 635                 640 


Val Tyr Ser Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His 
                645                 650                 655     


Leu Met Thr Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala 
            660                 665                 670         


Gly Gly Lys Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp 
        675                 680                 685             


Phe Gln Thr Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr 
    690                 695                 700                 


Ser Lys Phe Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu 
705                 710                 715                 720 


Tyr Glu Asp Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser 
                725                 730                 735     


Glu Gln Thr Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro 
            740                 745                 750         


Gln Gln Ala Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His 
        755                 760                 765             


Thr Lys Asn Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn 
    770                 775                 780                 


Arg Asn Ser Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys 
785                 790                 795                 800 


Asp Ile Leu Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn 
                805                 810                 815     


Asp Asp Lys Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His 
            820                 825                 830         


Leu Gly Lys Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp 
        835                 840                 845             


Phe Glu Lys Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly 
    850                 855                 860                 


Ile Gln Glu Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile 
865                 870                 875                 880 


Phe Phe Tyr Met His Asn Glu Ile Phe Glu Glu Met Leu Lys Arg Glu 
                885                 890                 895     


Glu Asn Ala Gln Leu Asn Ser Lys Glu Val Glu Glu Thr Leu Gln Lys 
            900                 905                 910         


Glu 
    


<210> 27
<211> 1318
<212> PRT
<213> Homo sapiens

<400> 27
Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly 
1               5                   10                  15      


Leu Glu Asp Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln 
            20                  25                  30          


Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val 
        35                  40                  45              


Ala Gln Ala Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser 
    50                  55                  60                  


Ala Ser His Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu 
65                  70                  75                  80  


Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln 
                85                  90                  95      


Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro 
            100                 105                 110         


Thr Pro Glu Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile 
        115                 120                 125             


Val Lys Leu Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp 
    130                 135                 140                 


Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln 
145                 150                 155                 160 


Gln Trp Gly Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys 
                165                 170                 175     


Val Gln Thr Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys 
            180                 185                 190         


Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln 
        195                 200                 205             


Leu Cys Ile Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu 
    210                 215                 220                 


Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn 
225                 230                 235                 240 


Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp 
                245                 250                 255     


Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu 
            260                 265                 270         


Val Asp Glu Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp 
        275                 280                 285             


Ser Tyr Glu Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys 
    290                 295                 300                 


Glu Ile Cys Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe 
305                 310                 315                 320 


Thr Leu Ile Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro 
                325                 330                 335     


Gly Cys Gly Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn 
            340                 345                 350         


Leu Ile Glu Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile 
        355                 360                 365             


Asp Ile Cys Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu 
    370                 375                 380                 


Ala Pro Ala Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly 
385                 390                 395                 400 


Pro Thr Pro Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu 
                405                 410                 415     


Thr Gly Gln Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala 
            420                 425                 430         


Arg Ser Glu Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met 
        435                 440                 445             


Glu His Val Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro 
    450                 455                 460                 


Thr Cys Met Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser 
465                 470                 475                 480 


Val Glu Glu Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe 
                485                 490                 495     


Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile 
            500                 505                 510         


Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg 
        515                 520                 525             


Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly 
    530                 535                 540                 


Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly 
545                 550                 555                 560 


Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser 
                565                 570                 575     


Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe 
            580                 585                 590         


Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln 
        595                 600                 605             


Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu 
    610                 615                 620                 


Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser 
625                 630                 635                 640 


Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys 
                645                 650                 655     


Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu 
            660                 665                 670         


Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe 
        675                 680                 685             


Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser 
    690                 695                 700                 


Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser 
705                 710                 715                 720 


Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn 
                725                 730                 735     


Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser 
            740                 745                 750         


Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala 
        755                 760                 765             


Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro 
    770                 775                 780                 


Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser 
785                 790                 795                 800 


Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr 
                805                 810                 815     


Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu 
            820                 825                 830         


Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala 
        835                 840                 845             


Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala 
    850                 855                 860                 


Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met 
865                 870                 875                 880 


Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly 
                885                 890                 895     


Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu 
            900                 905                 910         


Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg 
        915                 920                 925             


Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile 
    930                 935                 940                 


Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro 
945                 950                 955                 960 


Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln 
                965                 970                 975     


His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr 
            980                 985                 990         


Lys Ile Asp Ser Ser Asn Arg Glu  Gln Arg Leu Glu Asp  Lys Gly Asp 
        995                 1000                 1005             


Thr Pro  Leu Glu Leu Gly Asp  Asp Cys Ser Leu Ala  Leu Val Trp 
    1010                 1015                 1020             


Arg Asn  Asn Glu Arg Leu Gln  Glu Phe Val Leu Val  Ala Ser Lys 
    1025                 1030                 1035             


Glu Leu  Glu Cys Ala Glu Asp  Pro Gly Ser Ala Gly  Glu Ala Ala 
    1040                 1045                 1050             


Arg Ala  Gly His Phe Thr Leu  Asp Gln Cys Leu Asn  Leu Phe Thr 
    1055                 1060                 1065             


Arg Pro  Glu Val Leu Ala Pro  Glu Glu Ala Trp Tyr  Cys Pro Gln 
    1070                 1075                 1080             


Cys Lys  Gln His Arg Glu Ala  Ser Lys Gln Leu Leu  Leu Trp Arg 
    1085                 1090                 1095             


Leu Pro  Asn Val Leu Ile Val  Gln Leu Lys Arg Phe  Ser Phe Arg 
    1100                 1105                 1110             


Ser Phe  Ile Trp Arg Asp Lys  Ile Asn Asp Leu Val  Glu Phe Pro 
    1115                 1120                 1125             


Val Arg  Asn Leu Asp Leu Ser  Lys Phe Cys Ile Gly  Gln Lys Glu 
    1130                 1135                 1140             


Glu Gln  Leu Pro Ser Tyr Asp  Leu Tyr Ala Val Ile  Asn His Tyr 
    1145                 1150                 1155             


Gly Gly  Met Ile Gly Gly His  Tyr Thr Ala Cys Ala  Arg Leu Pro 
    1160                 1165                 1170             


Asn Asp  Arg Ser Ser Gln Arg  Ser Asp Val Gly Trp  Arg Leu Phe 
    1175                 1180                 1185             


Asp Asp  Ser Thr Val Thr Thr  Val Asp Glu Ser Gln  Val Val Thr 
    1190                 1195                 1200             


Arg Tyr  Ala Tyr Val Leu Phe  Tyr Arg Arg Arg Asn  Ser Pro Val 
    1205                 1210                 1215             


Glu Arg  Pro Pro Arg Ala Gly  His Ser Glu His His  Pro Asp Leu 
    1220                 1225                 1230             


Gly Pro  Ala Ala Glu Ala Ala  Ala Ser Gln Ala Ser  Arg Ile Trp 
    1235                 1240                 1245             


Gln Glu  Leu Glu Ala Glu Glu  Glu Pro Val Pro Glu  Gly Ser Gly 
    1250                 1255                 1260             


Pro Leu  Gly Pro Trp Gly Pro  Gln Asp Trp Val Gly  Pro Leu Pro 
    1265                 1270                 1275             


Arg Gly  Pro Thr Thr Pro Asp  Glu Gly Cys Leu Arg  Tyr Phe Val 
    1280                 1285                 1290             


Leu Gly  Thr Val Ala Ala Leu  Val Ala Leu Val Leu  Asn Val Phe 
    1295                 1300                 1305             


Tyr Pro  Leu Val Ser Gln Ser  Arg Trp Arg 
    1310                 1315             


<210> 28
<211> 798
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Leu His Ser Pro Gln Tyr Ile Phe Gly Asp Phe Ser Pro Asp 
1               5                   10                  15      


Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser Val Glu Leu Pro 
            20                  25                  30          


Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala Val Asp Lys Leu 
        35                  40                  45              


Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly Val Asp Glu Val 
    50                  55                  60                  


Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser Tyr Ser Ile Ser 
65                  70                  75                  80  


Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu Gly Cys Thr Ala 
                85                  90                  95      


Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala Ser Tyr Gly Ser 
            100                 105                 110         


Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu Asp Gly Ser Ser 
        115                 120                 125             


Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val Ser Gly Gly Leu 
    130                 135                 140                 


Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro Pro Gly Tyr Tyr 
145                 150                 155                 160 


Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser Thr Glu Ala Leu 
                165                 170                 175     


Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser Val Ser Ala Glu 
            180                 185                 190         


Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val Thr Pro Arg Thr 
        195                 200                 205             


Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser Asp Ile Val Pro 
    210                 215                 220                 


Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr Arg Thr Ala Gly 
225                 230                 235                 240 


Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln Ser Cys Phe Pro 
                245                 250                 255     


Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala Gly Ala Gln Pro 
            260                 265                 270         


Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val Ala Asn Gly Gln 
        275                 280                 285             


Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn Gly Val Glu Leu 
    290                 295                 300                 


His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys Pro Glu Ser Ala 
305                 310                 315                 320 


Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly Thr Leu Pro Val 
                325                 330                 335     


Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp Ser Lys Pro Ser 
            340                 345                 350         


Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr Ser Pro Pro Ala 
        355                 360                 365             


Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val Lys Glu Gly Leu 
    370                 375                 380                 


Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile Ala Glu Leu Leu 
385                 390                 395                 400 


Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu Gln Pro Arg Gly 
                405                 410                 415     


Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala Thr Leu Gln Ala 
            420                 425                 430         


Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys Phe Ile Pro Leu 
        435                 440                 445             


Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro Met Ile Asp Ser 
    450                 455                 460                 


Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro Val Pro Pro Lys 
465                 470                 475                 480 


Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp Ile Arg Pro Gly 
                485                 490                 495     


Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu Thr Val Asn Lys 
            500                 505                 510         


Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala Glu Glu Tyr Leu 
        515                 520                 525             


Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu Asn Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser Asn Gly Pro Lys 
545                 550                 555                 560 


Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln Gly Glu Gly Ser 
                565                 570                 575     


Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys Thr Ser Val Thr 
            580                 585                 590         


Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly Ile Phe Gly Gly 
        595                 600                 605             


His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys Glu Ser Ala Thr 
    610                 615                 620                 


Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln Ser Asp Lys Ile 
625                 630                 635                 640 


Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala Arg Glu Ser Val 
                645                 650                 655     


Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu Ile Ser Arg Arg 
            660                 665                 670         


Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu His Leu Lys Arg 
        675                 680                 685             


Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu Ile Lys Asn Ile 
    690                 695                 700                 


Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu Leu Ser Pro Gly 
705                 710                 715                 720 


Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr Arg Leu Phe Ala 
                725                 730                 735     


Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly His Tyr Thr Thr 
            740                 745                 750         


Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg Ile Asp Asp Gln 
        755                 760                 765             


Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys Pro Thr Ala Glu 
    770                 775                 780                 


Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp Leu Leu 
785                 790                 795             


<210> 29
<211> 688
<212> PRT
<213> Homo sapiens

<400> 29
Met Asp Arg Cys Lys His Val Gly Arg Leu Arg Leu Ala Gln Asp His 
1               5                   10                  15      


Ser Ile Leu Asn Pro Gln Lys Trp Cys Cys Leu Glu Cys Ala Thr Thr 
            20                  25                  30          


Glu Ser Val Trp Ala Cys Leu Lys Cys Ser His Val Ala Cys Gly Arg 
        35                  40                  45              


Tyr Ile Glu Asp His Ala Leu Lys His Phe Glu Glu Thr Gly His Pro 
    50                  55                  60                  


Leu Ala Met Glu Val Arg Asp Leu Tyr Val Phe Cys Tyr Leu Cys Lys 
65                  70                  75                  80  


Asp Tyr Val Leu Asn Asp Asn Pro Glu Gly Asp Leu Lys Leu Leu Arg 
                85                  90                  95      


Ser Ser Leu Leu Ala Val Arg Gly Gln Lys Gln Asp Thr Pro Val Arg 
            100                 105                 110         


Arg Gly Arg Thr Leu Arg Ser Met Ala Ser Gly Glu Asp Val Val Leu 
        115                 120                 125             


Pro Gln Arg Ala Pro Gln Gly Gln Pro Gln Met Leu Thr Ala Leu Trp 
    130                 135                 140                 


Tyr Arg Arg Gln Arg Leu Leu Ala Arg Thr Leu Arg Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ser Ser Arg Gly Gln Ala Lys Leu Glu Gln Arg Arg Gln Glu Glu 
                165                 170                 175     


Ala Leu Glu Arg Lys Lys Glu Glu Ala Arg Arg Arg Arg Arg Glu Val 
            180                 185                 190         


Lys Arg Arg Leu Leu Glu Glu Leu Ala Ser Thr Pro Pro Arg Lys Ser 
        195                 200                 205             


Ala Arg Leu Leu Leu His Thr Pro Arg Asp Ala Gly Pro Ala Ala Ser 
    210                 215                 220                 


Arg Pro Ala Ala Leu Pro Thr Ser Arg Arg Val Pro Ala Ala Thr Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Gln Pro Ala Met Ala Pro Gly Val Thr Gly Leu Arg 
                245                 250                 255     


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Ile Leu Gln Val Leu Ser 
            260                 265                 270         


His Leu Gln Lys Phe Arg Glu Cys Phe Leu Asn Leu Asp Pro Ser Lys 
        275                 280                 285             


Thr Glu His Leu Phe Pro Lys Ala Thr Asn Gly Lys Thr Gln Leu Ser 
    290                 295                 300                 


Gly Lys Pro Thr Asn Ser Ser Ala Thr Glu Leu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Arg Ala Glu Ala Cys Glu Arg Glu Gly Phe Cys Trp Asn Gly Arg Ala 
                325                 330                 335     


Ser Ile Ser Arg Ser Leu Glu Leu Ile Gln Asn Lys Glu Pro Ser Ser 
            340                 345                 350         


Lys His Ile Ser Leu Cys Arg Glu Leu His Thr Leu Phe Arg Val Met 
        355                 360                 365             


Trp Ser Gly Lys Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser 
    370                 375                 380                 


Val Trp Ser Leu Ile Pro Ala Phe Arg Gly Tyr Asp Gln Gln Asp Ala 
385                 390                 395                 400 


Gln Glu Phe Leu Cys Glu Leu Leu His Lys Val Gln Gln Glu Leu Glu 
                405                 410                 415     


Ser Glu Gly Thr Thr Arg Arg Ile Leu Ile Pro Phe Ser Gln Arg Lys 
            420                 425                 430         


Leu Thr Lys Gln Val Leu Lys Val Val Asn Thr Ile Phe His Gly Gln 
        435                 440                 445             


Leu Leu Ser Gln Val Thr Cys Ile Ser Cys Asn Tyr Lys Ser Asn Thr 
    450                 455                 460                 


Ile Glu Pro Phe Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr His 
465                 470                 475                 480 


Cys Ile Glu Lys Gly Phe Val Pro Leu Asn Gln Thr Glu Cys Leu Leu 
                485                 490                 495     


Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu Ala Leu Glu Gly Arg 
            500                 505                 510         


Ile Tyr Ala Cys Asp Gln Cys Asn Ser Lys Arg Arg Lys Ser Asn Pro 
        515                 520                 525             


Lys Pro Leu Val Leu Ser Glu Ala Arg Lys Gln Leu Met Ile Tyr Arg 
    530                 535                 540                 


Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg Phe Arg Trp Ser Gly 
545                 550                 555                 560 


Arg Asn His Arg Glu Lys Ile Gly Val His Val Val Phe Asp Gln Val 
                565                 570                 575     


Leu Thr Met Glu Pro Tyr Cys Cys Arg Asp Met Leu Ser Ser Leu Asp 
            580                 585                 590         


Lys Glu Thr Phe Ala Tyr Asp Leu Ser Ala Val Val Met His His Gly 
        595                 600                 605             


Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr Cys Tyr Asn Thr Glu 
    610                 615                 620                 


Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys Leu Asn Val Cys Ser 
625                 630                 635                 640 


Val Glu Glu Val Cys Lys Thr Gln Ala Tyr Ile Leu Phe Tyr Thr Gln 
                645                 650                 655     


Arg Thr Val Gln Gly Asn Ala Arg Ile Ser Glu Thr His Leu Gln Ala 
            660                 665                 670         


Gln Val Gln Ser Ser Asn Asn Asp Glu Gly Arg Pro Gln Thr Phe Ser 
        675                 680                 685             


<210> 30
<211> 530
<212> PRT
<213> Homo sapiens

<400> 30
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Pro Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Leu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr Pro Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Cys Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly Tyr Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Glu Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Met Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Met Asn Ser Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 31
<211> 350
<212> PRT
<213> Homo sapiens

<400> 31
Gly Ser Lys Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala 
1               5                   10                  15      


Thr Cys Tyr Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln 
            20                  25                  30          


Leu Arg Lys Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser 
        35                  40                  45              


Lys Ser Val Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His 
    50                  55                  60                  


Ser Asp Lys Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp 
65                  70                  75                  80  


Glu Thr Leu Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg 
                85                  90                  95      


Val Leu Leu Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu 
            100                 105                 110         


Gly Thr Ile Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln 
        115                 120                 125             


Cys Lys Glu Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp 
    130                 135                 140                 


Ile Gln Leu Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val 
145                 150                 155                 160 


Asp Tyr Val Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala 
                165                 170                 175     


Gly Glu His Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr 
            180                 185                 190         


Leu Pro Pro Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro 
        195                 200                 205             


Gln Thr Asp Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu 
    210                 215                 220                 


Gln Leu Pro Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro 
225                 230                 235                 240 


Ala Asn Tyr Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His 
                245                 250                 255     


Gly Gly His Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp 
            260                 265                 270         


Cys Lys Phe Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala 
        275                 280                 285             


Ile Glu His Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His 
    290                 295                 300                 


Cys Thr Asn Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser 
305                 310                 315                 320 


Glu Val Leu Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val 
                325                 330                 335     


Glu Arg Leu Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg 
            340                 345                 350 


<210> 32
<211> 343
<212> PRT
<213> Homo sapiens

<400> 32
Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp Tyr 
            20                  25                  30          


Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn Ala 
        35                  40                  45              


His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile Trp 
    50                  55                  60                  


Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr Gln 
65                  70                  75                  80  


Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val Asn 
            100                 105                 110         


Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His Leu 
        115                 120                 125             


Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu Arg 
    130                 135                 140                 


Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro Phe 
                165                 170                 175     


Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val Thr 
            180                 185                 190         


Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp Gly 
        195                 200                 205             


Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys Ile 
    210                 215                 220                 


Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His Leu 
225                 230                 235                 240 


Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr Phe 
                245                 250                 255     


Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser Glu 
            260                 265                 270         


Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His Ser 
        275                 280                 285             


Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro Gly 
    290                 295                 300                 


Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met Ser 
305                 310                 315                 320 


Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu Leu 
                325                 330                 335     


Ala Ser Pro Pro Ser Arg Met 
            340             


<210> 33
<211> 374
<212> PRT
<213> Homo sapiens

<400> 33
Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr 
1               5                   10                  15      


Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser 
            20                  25                  30          


Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val 
        35                  40                  45              


Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn 
    50                  55                  60                  


Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu 
65                  70                  75                  80  


Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu 
                85                  90                  95      


Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu 
            100                 105                 110         


Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln 
        115                 120                 125             


Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly 
    130                 135                 140                 


Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn 
145                 150                 155                 160 


Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg 
                165                 170                 175     


Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu 
            180                 185                 190         


Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile 
        195                 200                 205             


Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro 
    210                 215                 220                 


Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr 
225                 230                 235                 240 


Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val 
                245                 250                 255     


Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile 
            260                 265                 270         


Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser 
        275                 280                 285             


His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu 
    290                 295                 300                 


Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn 
305                 310                 315                 320 


Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met 
                325                 330                 335     


Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys 
            340                 345                 350         


Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro 
        355                 360                 365             


Thr Met Ser Leu Tyr Lys 
    370                 


<210> 34
<211> 530
<212> PRT
<213> Homo sapiens

<400> 34
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 35
<211> 525
<212> PRT
<213> Homo sapiens

<400> 35
Met Val Ser Arg Pro Glu Pro Glu Gly Glu Ala Met Asp Ala Glu Leu 
1               5                   10                  15      


Ala Val Ala Pro Pro Gly Cys Ser His Leu Gly Ser Phe Lys Val Asp 
            20                  25                  30          


Asn Trp Lys Gln Asn Leu Arg Ala Ile Tyr Gln Cys Phe Val Trp Ser 
        35                  40                  45              


Gly Thr Ala Glu Ala Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His 
    50                  55                  60                  


Val Cys Gly Val His Leu Asn Arg Leu His Ser Cys Leu Tyr Cys Val 
65                  70                  75                  80  


Phe Phe Gly Cys Phe Thr Lys Lys His Ile His Glu His Ala Lys Ala 
                85                  90                  95      


Lys Arg His Asn Leu Ala Ile Asp Leu Met Tyr Gly Gly Ile Tyr Cys 
            100                 105                 110         


Phe Leu Cys Gln Asp Tyr Ile Tyr Asp Lys Asp Met Glu Ile Ile Ala 
        115                 120                 125             


Lys Glu Glu Gln Arg Lys Ala Trp Lys Met Gln Gly Val Gly Glu Lys 
    130                 135                 140                 


Phe Ser Thr Trp Glu Pro Thr Lys Arg Glu Leu Glu Leu Leu Lys His 
145                 150                 155                 160 


Asn Pro Lys Arg Arg Lys Ile Thr Ser Asn Cys Thr Ile Gly Leu Arg 
                165                 170                 175     


Gly Leu Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln 
            180                 185                 190         


Ala Leu Thr His Thr Pro Leu Leu Arg Asp Phe Phe Leu Ser Asp Arg 
        195                 200                 205             


His Arg Cys Glu Met Gln Ser Pro Ser Ser Cys Leu Val Cys Glu Met 
    210                 215                 220                 


Ser Ser Leu Phe Gln Glu Phe Tyr Ser Gly His Arg Ser Pro His Ile 
225                 230                 235                 240 


Pro Tyr Lys Leu Leu His Leu Val Trp Thr His Ala Arg His Leu Ala 
                245                 250                 255     


Gly Tyr Glu Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp 
            260                 265                 270         


Val Leu His Arg His Cys Lys Gly Asp Asp Asn Gly Lys Lys Ala Asn 
        275                 280                 285             


Asn Pro Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly 
    290                 295                 300                 


Leu Gln Ser Asp Val Thr Cys Gln Val Cys His Gly Val Ser Thr Thr 
305                 310                 315                 320 


Ile Asp Pro Phe Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Ser Thr 
                325                 330                 335     


Pro Phe Trp Pro Leu Ser Pro Gly Ser Glu Gly Asn Val Val Asn Gly 
            340                 345                 350         


Glu Ser His Val Ser Gly Thr Thr Thr Leu Thr Asp Cys Leu Arg Arg 
        355                 360                 365             


Phe Thr Arg Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Ser 
    370                 375                 380                 


Gly Cys His Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys 
385                 390                 395                 400 


Leu Pro Ile Val Ala Cys Phe His Leu Lys Arg Phe Glu His Ser Ala 
                405                 410                 415     


Lys Leu Arg Arg Lys Ile Thr Thr Tyr Val Ser Phe Pro Leu Glu Leu 
            420                 425                 430         


Asp Met Thr Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly 
        435                 440                 445             


Gln Tyr Gln Gln Pro Thr Asp Ser Leu Asn Asn Asp Asn Lys Tyr Ser 
    450                 455                 460                 


Leu Phe Ala Val Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr 
465                 470                 475                 480 


Thr Ser Phe Ile Arg Gln His Lys Asp Gln Trp Phe Lys Cys Asp Asp 
                485                 490                 495     


Ala Ile Ile Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly 
            500                 505                 510         


Tyr Leu Leu Phe Tyr His Lys Gln Phe Leu Glu Tyr Glu 
        515                 520                 525 


<210> 36
<211> 372
<212> PRT
<213> Homo sapiens

<400> 36
Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Thr Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210> 37
<211> 1077
<212> PRT
<213> Homo sapiens

<400> 37
Met Thr Ala Glu Leu Gln Gln Asp Asp Ala Ala Gly Ala Ala Asp Gly 
1               5                   10                  15      


His Gly Ser Ser Cys Gln Met Leu Leu Asn Gln Leu Arg Glu Ile Thr 
            20                  25                  30          


Gly Ile Gln Asp Pro Ser Phe Leu His Glu Ala Leu Lys Ala Ser Asn 
        35                  40                  45              


Gly Asp Ile Thr Gln Ala Val Ser Leu Leu Thr Asp Glu Arg Val Lys 
    50                  55                  60                  


Glu Pro Ser Gln Asp Thr Val Ala Thr Glu Pro Ser Glu Val Glu Gly 
65                  70                  75                  80  


Ser Ala Ala Asn Lys Glu Val Leu Ala Lys Val Ile Asp Leu Thr His 
                85                  90                  95      


Asp Asn Lys Asp Asp Leu Gln Ala Ala Ile Ala Leu Ser Leu Leu Glu 
            100                 105                 110         


Ser Pro Lys Ile Gln Ala Asp Gly Arg Asp Leu Asn Arg Met His Glu 
        115                 120                 125             


Ala Thr Ser Ala Glu Thr Lys Arg Ser Lys Arg Lys Arg Cys Glu Val 
    130                 135                 140                 


Trp Gly Glu Asn Pro Asn Pro Asn Asp Trp Arg Arg Val Asp Gly Trp 
145                 150                 155                 160 


Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val 
                165                 170                 175     


Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val Leu Ser 
            180                 185                 190         


Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His Thr Glu 
        195                 200                 205             


Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu 
    210                 215                 220                 


Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp 
225                 230                 235                 240 


Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln Asp Val 
                245                 250                 255     


Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln 
            260                 265                 270         


Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn Pro Met 
        275                 280                 285             


Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu Gly 
    290                 295                 300                 


Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln Val 
305                 310                 315                 320 


Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val Glu 
                325                 330                 335     


Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly Gln 
            340                 345                 350         


Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu Ser 
        355                 360                 365             


Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His Asn 
    370                 375                 380                 


Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr Arg 
385                 390                 395                 400 


Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu Lys 
                405                 410                 415     


Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys Tyr 
            420                 425                 430         


Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr Val 
        435                 440                 445             


Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro Glu 
    450                 455                 460                 


Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser Val 
465                 470                 475                 480 


Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser Gln 
                485                 490                 495     


Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys Ser 
            500                 505                 510         


Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln Pro 
        515                 520                 525             


Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr Cys 
    530                 535                 540                 


Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu Lys 
545                 550                 555                 560 


Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys Asp 
                565                 570                 575     


Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu Val His 
            580                 585                 590         


Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr Asn Gln 
        595                 600                 605             


Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr Glu Ser 
    610                 615                 620                 


Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg Asn Val 
625                 630                 635                 640 


Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr Phe Asn 
                645                 650                 655     


Ala Glu Ala Ala Pro Thr Glu Ser Asp Gln Met Ser Glu Val Glu Ala 
            660                 665                 670         


Leu Ser Val Glu Leu Lys His Tyr Ile Gln Glu Asp Asn Trp Arg Phe 
        675                 680                 685             


Glu Gln Glu Val Glu Glu Trp Glu Glu Glu Gln Ser Cys Lys Ile Pro 
    690                 695                 700                 


Gln Met Glu Ser Ser Thr Asn Ser Ser Ser Gln Asp Tyr Ser Thr Ser 
705                 710                 715                 720 


Gln Glu Pro Ser Val Ala Ser Ser His Gly Val Arg Cys Leu Ser Ser 
                725                 730                 735     


Glu His Ala Val Ile Val Lys Glu Gln Thr Ala Gln Ala Ile Ala Asn 
            740                 745                 750         


Thr Ala Arg Ala Tyr Glu Lys Ser Gly Val Glu Ala Ala Leu Ser Glu 
        755                 760                 765             


Val Met Leu Ser Pro Ala Met Gln Gly Val Ile Leu Ala Ile Ala Lys 
    770                 775                 780                 


Ala Arg Gln Thr Phe Asp Arg Asp Gly Ser Glu Ala Gly Leu Ile Lys 
785                 790                 795                 800 


Ala Phe His Glu Glu Tyr Ser Arg Leu Tyr Gln Leu Ala Lys Glu Thr 
                805                 810                 815     


Pro Thr Ser His Ser Asp Pro Arg Leu Gln His Val Leu Val Tyr Phe 
            820                 825                 830         


Phe Gln Asn Glu Ala Pro Lys Arg Val Val Glu Arg Thr Leu Leu Glu 
        835                 840                 845             


Gln Phe Ala Asp Lys Asn Leu Ser Tyr Asp Glu Arg Ser Ile Ser Ile 
    850                 855                 860                 


Met Lys Val Ala Gln Ala Lys Leu Lys Glu Ile Gly Pro Asp Asp Met 
865                 870                 875                 880 


Asn Met Glu Glu Tyr Lys Lys Trp His Glu Asp Tyr Ser Leu Phe Arg 
                885                 890                 895     


Lys Val Ser Val Tyr Leu Leu Thr Gly Leu Glu Leu Tyr Gln Lys Gly 
            900                 905                 910         


Lys Tyr Gln Glu Ala Leu Ser Tyr Leu Val Tyr Ala Tyr Gln Ser Asn 
        915                 920                 925             


Ala Ala Leu Leu Met Lys Gly Pro Arg Arg Gly Val Lys Glu Ser Val 
    930                 935                 940                 


Ile Ala Leu Tyr Arg Arg Lys Cys Leu Leu Glu Leu Asn Ala Lys Ala 
945                 950                 955                 960 


Ala Ser Leu Phe Glu Thr Asn Asp Asp His Ser Val Thr Glu Gly Ile 
                965                 970                 975     


Asn Val Met Asn Glu Leu Ile Ile Pro Cys Ile His Leu Ile Ile Asn 
            980                 985                 990         


Asn Asp Ile Ser Lys Asp Asp Leu  Asp Ala Ile Glu Val  Met Arg Asn 
        995                 1000                 1005             


His Trp  Cys Ser Tyr Leu Gly  Gln Asp Ile Ala Glu  Asn Leu Gln 
    1010                 1015                 1020             


Leu Cys  Leu Gly Glu Phe Leu  Pro Arg Leu Leu Asp  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ile  Ile Val Leu Lys Glu  Pro Pro Thr Ile Arg  Pro Asn Ser 
    1040                 1045                 1050             


Pro Tyr  Asp Leu Cys Ser Arg  Phe Ala Ala Val Met  Glu Ser Ile 
    1055                 1060                 1065             


Gln Gly  Val Ser Thr Val Thr  Val Lys 
    1070                 1075         


<210> 38
<211> 530
<212> PRT
<213> Homo sapiens

<400> 38
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Ala Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Lys Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Lys Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu Arg Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Val Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 39
<211> 1352
<212> PRT
<213> Homo sapiens

<400> 39
Met Ser Lys Val Thr Ala Pro Gly Ser Gly Pro Pro Ala Ala Ala Ser 
1               5                   10                  15      


Gly Lys Glu Lys Arg Ser Phe Ser Lys Arg Leu Phe Arg Ser Gly Arg 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser Gly Pro Ala Ala 
        35                  40                  45              


Pro Ser Ser Pro Ser Ser Pro Ser Ser Ala Arg Ser Val Gly Ser Phe 
    50                  55                  60                  


Met Ser Arg Val Leu Lys Thr Leu Ser Thr Leu Ser His Leu Ser Ser 
65                  70                  75                  80  


Glu Gly Ala Ala Pro Asp Arg Gly Gly Leu Arg Ser Cys Phe Pro Pro 
                85                  90                  95      


Gly Pro Ala Ala Ala Pro Thr Pro Pro Pro Cys Pro Pro Pro Pro Ala 
            100                 105                 110         


Ser Pro Ala Pro Pro Ala Cys Ala Ala Glu Pro Val Pro Gly Val Ala 
        115                 120                 125             


Gly Leu Arg Asn His Gly Asn Thr Cys Phe Met Asn Ala Thr Leu Gln 
    130                 135                 140                 


Cys Leu Ser Asn Thr Glu Leu Phe Ala Glu Tyr Leu Ala Leu Gly Gln 
145                 150                 155                 160 


Tyr Arg Ala Gly Arg Pro Glu Pro Ser Pro Asp Pro Glu Gln Pro Ala 
                165                 170                 175     


Gly Arg Gly Ala Gln Gly Gln Gly Glu Val Thr Glu Gln Leu Ala His 
            180                 185                 190         


Leu Val Arg Ala Leu Trp Thr Leu Glu Tyr Thr Pro Gln His Ser Arg 
        195                 200                 205             


Asp Phe Lys Thr Ile Val Ser Lys Asn Ala Leu Gln Tyr Arg Gly Asn 
    210                 215                 220                 


Ser Gln His Asp Ala Gln Glu Phe Leu Leu Trp Leu Leu Asp Arg Val 
225                 230                 235                 240 


His Glu Asp Leu Asn His Ser Val Lys Gln Ser Gly Gln Pro Pro Leu 
                245                 250                 255     


Lys Pro Pro Ser Glu Thr Asp Met Met Pro Glu Gly Pro Ser Phe Pro 
            260                 265                 270         


Val Cys Ser Thr Phe Val Gln Glu Leu Phe Gln Ala Gln Tyr Arg Ser 
        275                 280                 285             


Ser Leu Thr Cys Pro His Cys Gln Lys Gln Ser Asn Thr Phe Asp Pro 
    290                 295                 300                 


Phe Leu Cys Ile Ser Leu Pro Ile Pro Leu Pro His Thr Arg Pro Leu 
305                 310                 315                 320 


Tyr Val Thr Val Val Tyr Gln Gly Lys Cys Ser His Cys Met Arg Ile 
                325                 330                 335     


Gly Val Ala Val Pro Leu Ser Gly Thr Val Ala Arg Leu Arg Glu Ala 
            340                 345                 350         


Val Ser Met Glu Thr Lys Ile Pro Thr Asp Gln Ile Val Leu Thr Glu 
        355                 360                 365             


Met Tyr Tyr Asp Gly Phe His Arg Ser Phe Cys Asp Thr Asp Asp Leu 
    370                 375                 380                 


Glu Thr Val His Glu Ser Asp Cys Ile Phe Ala Phe Glu Thr Pro Glu 
385                 390                 395                 400 


Ile Phe Arg Pro Glu Gly Ile Leu Ser Gln Arg Gly Ile His Leu Asn 
                405                 410                 415     


Asn Asn Leu Asn His Leu Lys Phe Gly Leu Asp Tyr His Arg Leu Ser 
            420                 425                 430         


Ser Pro Thr Gln Thr Ala Ala Lys Gln Gly Lys Met Asp Ser Pro Thr 
        435                 440                 445             


Ser Arg Ala Gly Ser Asp Lys Ile Val Leu Leu Val Cys Asn Arg Ala 
    450                 455                 460                 


Cys Thr Gly Gln Gln Gly Lys Arg Phe Gly Leu Pro Phe Val Leu His 
465                 470                 475                 480 


Leu Glu Lys Thr Ile Ala Trp Asp Leu Leu Gln Lys Glu Ile Leu Glu 
                485                 490                 495     


Lys Met Lys Tyr Phe Leu Arg Pro Thr Val Cys Ile Gln Val Cys Pro 
            500                 505                 510         


Phe Ser Leu Arg Val Val Ser Val Val Gly Ile Thr Tyr Leu Leu Pro 
        515                 520                 525             


Gln Glu Glu Gln Pro Leu Cys His Pro Ile Val Glu Arg Ala Leu Lys 
    530                 535                 540                 


Ser Cys Gly Pro Gly Gly Thr Ala His Val Lys Leu Val Val Glu Trp 
545                 550                 555                 560 


Asp Lys Glu Thr Arg Asp Phe Leu Phe Val Asn Thr Glu Asp Glu Tyr 
                565                 570                 575     


Ile Pro Asp Ala Glu Ser Val Arg Leu Gln Arg Glu Arg His His Gln 
            580                 585                 590         


Pro Gln Thr Cys Thr Leu Ser Gln Cys Phe Gln Leu Tyr Thr Lys Glu 
        595                 600                 605             


Glu Arg Leu Ala Pro Asp Asp Ala Trp Arg Cys Pro His Cys Lys Gln 
    610                 615                 620                 


Leu Gln Gln Gly Ser Ile Thr Leu Ser Leu Trp Thr Leu Pro Asp Val 
625                 630                 635                 640 


Leu Ile Ile His Leu Lys Arg Phe Arg Gln Glu Gly Asp Arg Arg Met 
                645                 650                 655     


Lys Leu Gln Asn Met Val Lys Phe Pro Leu Thr Gly Leu Asp Met Thr 
            660                 665                 670         


Pro His Val Val Lys Arg Ser Gln Ser Ser Trp Ser Leu Pro Ser His 
        675                 680                 685             


Trp Ser Pro Trp Arg Arg Pro Tyr Gly Leu Gly Arg Asp Pro Glu Asp 
    690                 695                 700                 


Tyr Ile Tyr Asp Leu Tyr Ala Val Cys Asn His His Gly Thr Met Gln 
705                 710                 715                 720 


Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn Ser Val Asp Gly Leu Trp 
                725                 730                 735     


Tyr Cys Phe Asp Asp Ser Asp Val Gln Gln Leu Ser Glu Asp Glu Val 
            740                 745                 750         


Cys Thr Gln Thr Ala Tyr Ile Leu Phe Tyr Gln Arg Arg Thr Ala Ile 
        755                 760                 765             


Pro Ser Trp Ser Ala Asn Ser Ser Val Ala Gly Ser Thr Ser Ser Ser 
    770                 775                 780                 


Leu Cys Glu His Trp Val Ser Arg Leu Pro Gly Ser Lys Pro Ala Ser 
785                 790                 795                 800 


Val Thr Ser Ala Ala Ser Ser Arg Arg Thr Ser Leu Ala Ser Leu Ser 
                805                 810                 815     


Glu Ser Val Glu Met Thr Gly Glu Arg Ser Glu Asp Asp Gly Gly Phe 
            820                 825                 830         


Ser Thr Arg Pro Phe Val Arg Ser Val Gln Arg Gln Ser Leu Ser Ser 
        835                 840                 845             


Arg Ser Ser Val Thr Ser Pro Leu Ala Val Asn Glu Asn Cys Met Arg 
    850                 855                 860                 


Pro Ser Trp Ser Leu Ser Ala Lys Leu Gln Met Arg Ser Asn Ser Pro 
865                 870                 875                 880 


Ser Arg Phe Ser Gly Asp Ser Pro Ile His Ser Ser Ala Ser Thr Leu 
                885                 890                 895     


Glu Lys Ile Gly Glu Ala Ala Asp Asp Lys Val Ser Ile Ser Cys Phe 
            900                 905                 910         


Gly Ser Leu Arg Asn Leu Ser Ser Ser Tyr Gln Glu Pro Ser Asp Ser 
        915                 920                 925             


His Ser Arg Arg Glu His Lys Ala Val Gly Arg Ala Pro Leu Ala Val 
    930                 935                 940                 


Met Glu Gly Val Phe Lys Asp Glu Ser Asp Thr Arg Arg Leu Asn Ser 
945                 950                 955                 960 


Ser Val Val Asp Thr Gln Ser Lys His Ser Ala Gln Gly Asp Arg Leu 
                965                 970                 975     


Pro Pro Leu Ser Gly Pro Phe Asp Asn Asn Asn Gln Ile Ala Tyr Val 
            980                 985                 990         


Asp Gln Ser Asp Ser Val Asp Ser  Ser Pro Val Lys Glu  Val Lys Ala 
        995                 1000                 1005             


Pro Ser  His Pro Gly Ser Leu  Ala Lys Lys Pro Glu  Ser Thr Thr 
    1010                 1015                 1020             


Lys Arg  Ser Pro Ser Ser Lys  Gly Thr Ser Glu Pro  Glu Lys Ser 
    1025                 1030                 1035             


Leu Arg  Lys Gly Arg Pro Ala  Leu Ala Ser Gln Glu  Ser Ser Leu 
    1040                 1045                 1050             


Ser Ser  Thr Ser Pro Ser Ser  Pro Leu Pro Val Lys  Val Ser Leu 
    1055                 1060                 1065             


Lys Pro  Ser Arg Ser Arg Ser  Lys Ala Asp Ser Ser  Ser Arg Gly 
    1070                 1075                 1080             


Ser Gly  Arg His Ser Ser Pro  Ala Pro Ala Gln Pro  Lys Lys Glu 
    1085                 1090                 1095             


Ser Ser  Pro Lys Ser Gln Asp  Ser Val Ser Ser Pro  Ser Pro Gln 
    1100                 1105                 1110             


Lys Gln  Lys Ser Ala Ser Ala  Leu Thr Tyr Thr Ala  Ser Ser Thr 
    1115                 1120                 1125             


Ser Ala  Lys Lys Ala Ser Gly  Pro Ala Thr Arg Ser  Pro Phe Pro 
    1130                 1135                 1140             


Pro Gly  Lys Ser Arg Thr Ser  Asp His Ser Leu Ser  Arg Glu Gly 
    1145                 1150                 1155             


Ser Arg  Gln Ser Leu Gly Ser  Asp Arg Ala Ser Ala  Thr Ser Thr 
    1160                 1165                 1170             


Ser Lys  Pro Asn Ser Pro Arg  Val Ser Gln Ala Arg  Ala Gly Glu 
    1175                 1180                 1185             


Gly Arg  Gly Ala Gly Lys His  Val Arg Ser Ser Ser  Met Ala Ser 
    1190                 1195                 1200             


Leu Arg  Ser Pro Ser Thr Ser  Ile Lys Ser Gly Leu  Lys Arg Asp 
    1205                 1210                 1215             


Ser Lys  Ser Glu Asp Lys Gly  Leu Ser Phe Phe Lys  Ser Ala Leu 
    1220                 1225                 1230             


Arg Gln  Lys Glu Thr Arg Arg  Ser Thr Asp Leu Gly  Lys Thr Ala 
    1235                 1240                 1245             


Leu Leu  Ser Lys Lys Ala Gly  Gly Ser Ser Val Lys  Ser Val Cys 
    1250                 1255                 1260             


Lys Asn  Thr Gly Asp Asp Glu  Ala Glu Arg Gly His  Gln Pro Pro 
    1265                 1270                 1275             


Ala Ser  Gln Gln Pro Asn Ala  Asn Thr Thr Gly Lys  Glu Gln Leu 
    1280                 1285                 1290             


Val Thr  Lys Asp Pro Ala Ser  Ala Lys His Ser Leu  Leu Ser Ala 
    1295                 1300                 1305             


Arg Lys  Ser Lys Ser Ser Gln  Leu Asp Ser Gly Val  Pro Ser Ser 
    1310                 1315                 1320             


Pro Gly  Gly Arg Gln Ser Ala  Glu Lys Ser Ser Lys  Lys Leu Ser 
    1325                 1330                 1335             


Ser Ser  Met Gln Thr Ser Ala  Arg Pro Ser Gln Lys  Pro Gln 
    1340                 1345                 1350         


<210> 40
<211> 530
<212> PRT
<213> Homo sapiens

<400> 40
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Lys Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 41
<211> 553
<212> PRT
<213> Homo sapiens

<400> 41
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Asp Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Lys 
    290                 295                 300                 


Leu Tyr Met Ser Gln Thr Asn Ser Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln Trp Ser Gln Trp Lys Tyr Arg Pro Thr Arg Arg Gly Ala His 
    530                 535                 540                 


Thr His Ala His Thr Gln Thr His Thr 
545                 550             


<210> 42
<211> 1375
<212> PRT
<213> Homo sapiens

<400> 42
Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Asp Val Phe 
1               5                   10                  15      


Trp Arg Cys Arg Gln Asn Ile Phe Asp Glu Met Lys Lys Lys Phe Leu 
            20                  25                  30          


Gln Ile Glu Asn Ala Ala Glu Glu Pro Arg Val Leu Cys Ile Ile Gln 
        35                  40                  45              


Asp Thr Thr Asn Ser Lys Thr Val Asn Glu Arg Ile Thr Leu Asn Leu 
    50                  55                  60                  


Pro Ala Ser Thr Pro Val Arg Lys Leu Phe Glu Asp Val Ala Asn Lys 
65                  70                  75                  80  


Val Gly Tyr Ile Asn Gly Thr Phe Asp Leu Val Trp Gly Asn Gly Ile 
                85                  90                  95      


Asn Thr Ala Asp Met Ala Pro Leu Asp His Thr Ser Asp Lys Ser Leu 
            100                 105                 110         


Leu Asp Ala Asn Phe Glu Pro Gly Lys Lys Asn Phe Leu His Leu Thr 
        115                 120                 125             


Asp Lys Asp Gly Glu Gln Pro Gln Ile Leu Leu Glu Asp Ser Ser Ala 
    130                 135                 140                 


Gly Glu Asp Ser Val His Asp Arg Phe Ile Gly Pro Leu Pro Arg Glu 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Thr Ser Asp Tyr Val Ser Gln Ser Tyr Ser Tyr 
                165                 170                 175     


Ser Ser Ile Leu Asn Lys Ser Glu Thr Gly Tyr Val Gly Leu Val Asn 
            180                 185                 190         


Gln Ala Met Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu Phe Met 
        195                 200                 205             


Thr Pro Glu Phe Arg Asn Ala Leu Tyr Lys Trp Glu Phe Glu Glu Ser 
    210                 215                 220                 


Glu Glu Asp Pro Val Thr Ser Ile Pro Tyr Gln Leu Gln Arg Leu Phe 
225                 230                 235                 240 


Val Leu Leu Gln Thr Ser Lys Lys Arg Ala Ile Glu Thr Thr Asp Val 
                245                 250                 255     


Thr Arg Ser Phe Gly Trp Asp Ser Ser Glu Ala Trp Gln Gln His Asp 
            260                 265                 270         


Val Gln Glu Leu Cys Arg Val Met Phe Asp Ala Leu Glu Gln Lys Trp 
        275                 280                 285             


Lys Gln Thr Glu Gln Ala Asp Leu Ile Asn Glu Leu Tyr Gln Gly Lys 
    290                 295                 300                 


Leu Lys Asp Tyr Val Arg Cys Leu Glu Cys Gly Tyr Glu Gly Trp Arg 
305                 310                 315                 320 


Ile Asp Thr Tyr Leu Asp Ile Pro Leu Val Ile Arg Pro Tyr Gly Ser 
                325                 330                 335     


Ser Gln Ala Phe Ala Ser Val Glu Glu Ala Leu His Ala Phe Ile Gln 
            340                 345                 350         


Pro Glu Ile Leu Asp Gly Pro Asn Gln Tyr Phe Cys Glu Arg Cys Lys 
        355                 360                 365             


Lys Lys Cys Asp Ala Arg Lys Gly Leu Arg Phe Leu His Phe Pro Tyr 
    370                 375                 380                 


Leu Leu Thr Leu Gln Leu Lys Arg Phe Asp Phe Asp Tyr Thr Thr Met 
385                 390                 395                 400 


His Arg Ile Lys Leu Asn Asp Arg Met Thr Phe Pro Glu Glu Leu Asp 
                405                 410                 415     


Met Ser Thr Phe Ile Asp Val Glu Asp Glu Lys Ser Pro Gln Thr Glu 
            420                 425                 430         


Ser Cys Thr Asp Ser Gly Ala Glu Asn Glu Gly Ser Cys His Ser Asp 
        435                 440                 445             


Gln Met Ser Asn Asp Phe Ser Asn Asp Asp Gly Val Asp Glu Gly Ile 
    450                 455                 460                 


Cys Leu Glu Thr Asn Ser Gly Thr Glu Lys Ile Ser Lys Ser Gly Leu 
465                 470                 475                 480 


Glu Lys Asn Ser Leu Ile Tyr Glu Leu Phe Ser Val Met Val His Ser 
                485                 490                 495     


Gly Ser Ala Ala Gly Gly His Tyr Tyr Ala Cys Ile Lys Ser Phe Ser 
            500                 505                 510         


Asp Glu Gln Trp Tyr Ser Phe Asn Asp Gln His Val Ser Arg Ile Thr 
        515                 520                 525             


Gln Glu Asp Ile Lys Lys Thr His Gly Gly Ser Ser Gly Ser Arg Gly 
    530                 535                 540                 


Tyr Tyr Ser Ser Ala Phe Ala Ser Ser Thr Asn Ala Tyr Met Leu Ile 
545                 550                 555                 560 


Tyr Arg Leu Lys Asp Pro Ala Arg Asn Ala Lys Phe Leu Glu Val Asp 
                565                 570                 575     


Glu Tyr Pro Glu His Ile Lys Asn Leu Val Gln Lys Glu Arg Glu Leu 
            580                 585                 590         


Glu Glu Gln Glu Lys Arg Gln Arg Glu Ile Glu Arg Asn Thr Cys Lys 
        595                 600                 605             


Ile Lys Leu Phe Cys Leu His Pro Thr Lys Gln Val Met Met Glu Asn 
    610                 615                 620                 


Lys Leu Glu Val His Lys Asp Lys Thr Leu Lys Glu Ala Val Glu Met 
625                 630                 635                 640 


Ala Tyr Lys Met Met Asp Leu Glu Glu Val Ile Pro Leu Asp Cys Cys 
                645                 650                 655     


Arg Leu Val Lys Tyr Asp Glu Phe His Asp Tyr Leu Glu Arg Ser Tyr 
            660                 665                 670         


Glu Gly Glu Glu Asp Thr Pro Met Gly Leu Leu Leu Gly Gly Val Lys 
        675                 680                 685             


Ser Thr Tyr Met Phe Asp Leu Leu Leu Glu Thr Arg Lys Pro Asp Gln 
    690                 695                 700                 


Val Phe Gln Ser Tyr Lys Pro Gly Glu Val Met Val Lys Val His Val 
705                 710                 715                 720 


Val Asp Leu Lys Ala Glu Ser Val Ala Ala Pro Ile Thr Val Arg Ala 
                725                 730                 735     


Tyr Leu Asn Gln Thr Val Thr Glu Phe Lys Gln Leu Ile Ser Lys Ala 
            740                 745                 750         


Ile His Leu Pro Ala Glu Thr Met Arg Ile Val Leu Glu Arg Cys Tyr 
        755                 760                 765             


Asn Asp Leu Arg Leu Leu Ser Val Ser Ser Lys Thr Leu Lys Ala Glu 
    770                 775                 780                 


Gly Phe Phe Arg Ser Asn Lys Val Phe Val Glu Ser Ser Glu Thr Leu 
785                 790                 795                 800 


Asp Tyr Gln Met Ala Phe Ala Asp Ser His Leu Trp Lys Leu Leu Asp 
                805                 810                 815     


Arg His Ala Asn Thr Ile Arg Leu Phe Val Leu Leu Pro Glu Gln Ser 
            820                 825                 830         


Pro Val Ser Tyr Ser Lys Arg Thr Ala Tyr Gln Lys Ala Gly Gly Asp 
        835                 840                 845             


Ser Gly Asn Val Asp Asp Asp Cys Glu Arg Val Lys Gly Pro Val Gly 
    850                 855                 860                 


Ser Leu Lys Ser Val Glu Ala Ile Leu Glu Glu Ser Thr Glu Lys Leu 
865                 870                 875                 880 


Lys Ser Leu Ser Leu Gln Gln Gln Gln Asp Gly Asp Asn Gly Asp Ser 
                885                 890                 895     


Ser Lys Ser Thr Glu Thr Ser Asp Phe Glu Asn Ile Glu Ser Pro Leu 
            900                 905                 910         


Asn Glu Arg Asp Ser Ser Ala Ser Val Asp Asn Arg Glu Leu Glu Gln 
        915                 920                 925             


His Ile Gln Thr Ser Asp Pro Glu Asn Phe Gln Ser Glu Glu Arg Ser 
    930                 935                 940                 


Asp Ser Asp Val Asn Asn Asp Arg Ser Thr Ser Ser Val Asp Ser Asp 
945                 950                 955                 960 


Ile Leu Ser Ser Ser His Ser Ser Asp Thr Leu Cys Asn Ala Asp Asn 
                965                 970                 975     


Ala Gln Ile Pro Leu Ala Asn Gly Leu Asp Ser His Ser Ile Thr Ser 
            980                 985                 990         


Ser Arg Arg Thr Lys Ala Asn Glu  Gly Lys Lys Glu Thr  Trp Asp Thr 
        995                 1000                 1005             


Ala Glu  Glu Asp Ser Gly Thr  Asp Ser Glu Tyr Asp  Glu Ser Gly 
    1010                 1015                 1020             


Lys Ser  Arg Gly Glu Met Gln  Tyr Met Tyr Phe Lys  Ala Glu Pro 
    1025                 1030                 1035             


Tyr Ala  Ala Asp Glu Gly Ser  Gly Glu Gly His Lys  Trp Leu Met 
    1040                 1045                 1050             


Val His  Val Asp Lys Arg Ile  Thr Leu Ala Ala Phe  Lys Gln His 
    1055                 1060                 1065             


Leu Glu  Pro Phe Val Gly Val  Leu Ser Ser His Phe  Lys Val Phe 
    1070                 1075                 1080             


Arg Val  Tyr Ala Ser Asn Gln  Glu Phe Glu Ser Val  Arg Leu Asn 
    1085                 1090                 1095             


Glu Thr  Leu Ser Ser Phe Ser  Asp Asp Asn Lys Ile  Thr Ile Arg 
    1100                 1105                 1110             


Leu Gly  Arg Ala Leu Lys Lys  Gly Glu Tyr Arg Val  Lys Val Tyr 
    1115                 1120                 1125             


Gln Leu  Leu Val Asn Glu Gln  Glu Pro Cys Lys Phe  Leu Leu Asp 
    1130                 1135                 1140             


Ala Val  Phe Ala Lys Gly Met  Thr Val Arg Gln Ser  Lys Glu Glu 
    1145                 1150                 1155             


Leu Ile  Pro Gln Leu Arg Glu  Gln Cys Gly Leu Glu  Leu Ser Ile 
    1160                 1165                 1170             


Asp Arg  Phe Arg Leu Arg Lys  Lys Thr Trp Lys Asn  Pro Gly Thr 
    1175                 1180                 1185             


Val Phe  Leu Asp Tyr His Ile  Tyr Glu Glu Asp Ile  Asn Ile Ser 
    1190                 1195                 1200             


Ser Asn  Trp Glu Val Phe Leu  Glu Val Leu Asp Gly  Val Glu Lys 
    1205                 1210                 1215             


Met Lys  Ser Met Ser Gln Leu  Ala Val Leu Ser Arg  Arg Trp Lys 
    1220                 1225                 1230             


Pro Ser  Glu Met Lys Leu Asp  Pro Phe Gln Glu Val  Val Leu Glu 
    1235                 1240                 1245             


Ser Ser  Ser Val Asp Glu Leu  Arg Glu Lys Leu Ser  Glu Ile Ser 
    1250                 1255                 1260             


Gly Ile  Pro Leu Asp Asp Ile  Glu Phe Ala Lys Gly  Arg Gly Thr 
    1265                 1270                 1275             


Phe Pro  Cys Asp Ile Ser Val  Leu Asp Ile His Gln  Asp Leu Asp 
    1280                 1285                 1290             


Trp Asn  Pro Lys Val Ser Thr  Leu Asn Val Trp Pro  Leu Tyr Ile 
    1295                 1300                 1305             


Cys Asp  Asp Gly Ala Val Ile  Phe Tyr Arg Asp Lys  Thr Glu Glu 
    1310                 1315                 1320             


Leu Met  Glu Leu Thr Asp Glu  Gln Arg Asn Glu Leu  Met Lys Lys 
    1325                 1330                 1335             


Glu Ser  Ser Arg Leu Gln Lys  Thr Gly His Arg Val  Thr Tyr Ser 
    1340                 1345                 1350             


Pro Arg  Lys Glu Lys Ala Leu  Lys Ile Tyr Leu Asp  Gly Ala Pro 
    1355                 1360                 1365             


Asn Lys  Asp Leu Thr Gln Asp  
    1370                 1375 


<210> 43
<211> 711
<212> PRT
<213> Homo sapiens

<400> 43
Met Ala Gln Val Arg Glu Thr Ser Leu Pro Ser Gly Ser Gly Val Arg 
1               5                   10                  15      


Trp Ile Ser Gly Gly Gly Gly Gly Ala Ser Pro Glu Glu Ala Val Glu 
            20                  25                  30          


Lys Ala Gly Lys Met Glu Glu Ala Ala Ala Gly Ala Thr Lys Ala Ser 
        35                  40                  45              


Ser Arg Arg Glu Ala Glu Glu Met Lys Leu Glu Pro Leu Gln Glu Arg 
    50                  55                  60                  


Glu Pro Ala Pro Glu Glu Asn Leu Thr Trp Ser Ser Ser Gly Gly Asp 
65                  70                  75                  80  


Glu Lys Val Leu Pro Ser Ile Pro Leu Arg Cys His Ser Ser Ser Ser 
                85                  90                  95      


Pro Val Cys Pro Arg Arg Lys Pro Arg Pro Arg Pro Gln Pro Arg Ala 
            100                 105                 110         


Arg Ser Arg Ser Gln Pro Gly Leu Ser Ala Pro Pro Pro Pro Pro Ala 
        115                 120                 125             


Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Arg Pro 
    130                 135                 140                 


Arg Ala Trp Arg Gly Ser Arg Arg Arg Ser Arg Pro Gly Ser Arg Pro 
145                 150                 155                 160 


Gln Thr Arg Arg Ser Cys Ser Gly Asp Leu Asp Gly Ser Gly Asp Pro 
                165                 170                 175     


Gly Gly Leu Gly Asp Trp Leu Leu Glu Val Glu Phe Gly Gln Gly Pro 
            180                 185                 190         


Thr Gly Cys Ser His Val Glu Ser Phe Lys Val Gly Lys Asn Trp Gln 
        195                 200                 205             


Lys Asn Leu Arg Leu Ile Tyr Gln Arg Phe Val Trp Ser Gly Thr Pro 
    210                 215                 220                 


Glu Thr Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His Val Cys Ser 
225                 230                 235                 240 


Thr His Met Asn Arg Leu His Ser Cys Leu Ser Cys Val Phe Phe Gly 
                245                 250                 255     


Cys Phe Thr Glu Lys His Ile His Lys His Ala Glu Thr Lys Gln His 
            260                 265                 270         


His Leu Ala Val Asp Leu Tyr His Gly Val Ile Tyr Cys Phe Met Cys 
        275                 280                 285             


Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys Glu Thr 
    290                 295                 300                 


Lys Glu Lys Ile Leu Arg Leu Leu Thr Ser Thr Ser Thr Asp Val Ser 
305                 310                 315                 320 


His Gln Gln Phe Met Thr Ser Gly Phe Glu Asp Lys Gln Ser Thr Cys 
                325                 330                 335     


Glu Thr Lys Glu Gln Glu Pro Lys Leu Val Lys Pro Lys Lys Lys Arg 
            340                 345                 350         


Arg Lys Lys Ser Val Tyr Thr Val Gly Leu Arg Gly Leu Ile Asn Leu 
        355                 360                 365             


Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His Ile 
    370                 375                 380                 


Pro Leu Leu Lys Asp Phe Phe Leu Ser Asp Lys His Lys Cys Ile Met 
385                 390                 395                 400 


Thr Ser Pro Ser Leu Cys Leu Val Cys Glu Met Ser Ser Leu Phe His 
                405                 410                 415     


Ala Met Tyr Ser Gly Ser Arg Thr Pro His Ile Pro Tyr Lys Leu Leu 
            420                 425                 430         


His Leu Ile Trp Ile His Ala Glu His Leu Ala Gly Tyr Arg Gln Gln 
        435                 440                 445             


Asp Ala His Glu Phe Leu Ile Ala Ile Leu Asp Val Leu His Arg His 
    450                 455                 460                 


Ser Lys Asp Asp Ser Gly Gly Gln Glu Ala Asn Asn Pro Asn Cys Cys 
465                 470                 475                 480 


Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val 
                485                 490                 495     


Thr Cys Gln Ala Cys His Ser Val Ser Thr Thr Ile Asp Pro Cys Trp 
            500                 505                 510         


Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Ala Thr Phe Asp Ser Gln 
        515                 520                 525             


Asn Pro Glu Arg Ala Asp Ser Thr Val Ser Arg Asp Asp His Ile Pro 
    530                 535                 540                 


Gly Ile Pro Ser Leu Thr Asp Cys Leu Gln Trp Phe Thr Arg Pro Glu 
545                 550                 555                 560 


His Leu Gly Ser Ser Ala Lys Ile Lys Cys Asn Ser Cys Gln Ser Tyr 
                565                 570                 575     


Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile Val Ala 
            580                 585                 590         


Cys Phe His Leu Lys Arg Phe Glu His Val Gly Lys Gln Arg Arg Lys 
        595                 600                 605             


Ile Asn Thr Phe Ile Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe 
    610                 615                 620                 


Leu Ala Ser Thr Lys Glu Ser Arg Met Lys Glu Gly Gln Pro Pro Thr 
625                 630                 635                 640 


Asp Cys Val Pro Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val Ile Asn 
                645                 650                 655     


His His Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile Arg Gln 
            660                 665                 670         


Gln Lys Asp Gln Trp Phe Ser Cys Asp Asp Ala Ile Ile Thr Lys Ala 
        675                 680                 685             


Thr Ile Glu Asp Leu Leu Tyr Ser Glu Gly Tyr Leu Leu Phe Tyr His 
    690                 695                 700                 


Lys Gln Gly Leu Glu Lys Asp 
705                 710     


<210> 44
<211> 1123
<212> PRT
<213> Homo sapiens

<400> 44
Met Pro Ile Val Asp Lys Leu Lys Glu Ala Leu Lys Pro Gly Arg Lys 
1               5                   10                  15      


Asp Ser Ala Asp Asp Gly Glu Leu Gly Lys Leu Leu Ala Ser Ser Ala 
            20                  25                  30          


Lys Lys Val Leu Leu Gln Lys Ile Glu Phe Glu Pro Ala Ser Lys Ser 
        35                  40                  45              


Phe Ser Tyr Gln Leu Glu Ala Leu Lys Ser Lys Tyr Val Leu Leu Asn 
    50                  55                  60                  


Pro Lys Thr Glu Gly Ala Ser Arg His Lys Ser Gly Asp Asp Pro Pro 
65                  70                  75                  80  


Ala Arg Arg Gln Gly Ser Glu His Thr Tyr Glu Ser Cys Gly Asp Gly 
                85                  90                  95      


Val Pro Ala Pro Gln Lys Val Leu Phe Pro Thr Glu Arg Leu Ser Leu 
            100                 105                 110         


Arg Trp Glu Arg Val Phe Arg Val Gly Ala Gly Leu His Asn Leu Gly 
        115                 120                 125             


Asn Thr Cys Phe Leu Asn Ala Thr Ile Gln Cys Leu Thr Tyr Thr Pro 
    130                 135                 140                 


Pro Leu Ala Asn Tyr Leu Leu Ser Lys Glu His Ala Arg Ser Cys His 
145                 150                 155                 160 


Gln Gly Ser Phe Cys Met Leu Cys Val Met Gln Asn His Ile Val Gln 
                165                 170                 175     


Ala Phe Ala Asn Ser Gly Asn Ala Ile Lys Pro Val Ser Phe Ile Arg 
            180                 185                 190         


Asp Leu Lys Lys Ile Ala Arg His Phe Arg Phe Gly Asn Gln Glu Asp 
        195                 200                 205             


Ala His Glu Phe Leu Arg Tyr Thr Ile Asp Ala Met Gln Lys Ala Cys 
    210                 215                 220                 


Leu Asn Gly Cys Ala Lys Leu Asp Arg Gln Thr Gln Ala Thr Thr Leu 
225                 230                 235                 240 


Val His Gln Ile Phe Gly Gly Tyr Leu Arg Ser Arg Val Lys Cys Ser 
                245                 250                 255     


Val Cys Lys Ser Val Ser Asp Thr Tyr Asp Pro Tyr Leu Asp Val Ala 
            260                 265                 270         


Leu Glu Ile Arg Gln Ala Ala Asn Ile Val Arg Ala Leu Glu Leu Phe 
        275                 280                 285             


Val Lys Ala Asp Val Leu Ser Gly Glu Asn Ala Tyr Met Cys Ala Lys 
    290                 295                 300                 


Cys Lys Lys Lys Val Pro Ala Ser Lys Arg Phe Thr Ile His Arg Thr 
305                 310                 315                 320 


Ser Asn Val Leu Thr Leu Ser Leu Lys Arg Phe Ala Asn Phe Ser Gly 
                325                 330                 335     


Gly Lys Ile Thr Lys Asp Val Gly Tyr Pro Glu Phe Leu Asn Ile Arg 
            340                 345                 350         


Pro Tyr Met Ser Gln Asn Asn Gly Asp Pro Val Met Tyr Gly Leu Tyr 
        355                 360                 365             


Ala Val Leu Val His Ser Gly Tyr Ser Cys His Ala Gly His Tyr Tyr 
    370                 375                 380                 


Cys Tyr Val Lys Ala Ser Asn Gly Gln Trp Tyr Gln Met Asn Asp Ser 
385                 390                 395                 400 


Leu Val His Ser Ser Asn Val Lys Val Val Leu Asn Gln Gln Ala Tyr 
                405                 410                 415     


Val Leu Phe Tyr Leu Arg Ile Pro Gly Ser Lys Lys Ser Pro Glu Gly 
            420                 425                 430         


Leu Ile Ser Arg Thr Gly Ser Ser Ser Leu Pro Gly Arg Pro Ser Val 
        435                 440                 445             


Ile Pro Asp His Ser Lys Lys Asn Ile Gly Asn Gly Ile Ile Ser Ser 
    450                 455                 460                 


Pro Leu Thr Gly Lys Arg Gln Asp Ser Gly Thr Met Lys Lys Pro His 
465                 470                 475                 480 


Thr Thr Glu Glu Ile Gly Val Pro Ile Ser Arg Asn Gly Ser Thr Leu 
                485                 490                 495     


Gly Leu Lys Ser Gln Asn Gly Cys Ile Pro Pro Lys Leu Pro Ser Gly 
            500                 505                 510         


Ser Pro Ser Pro Lys Leu Ser Gln Thr Pro Thr His Met Pro Thr Ile 
        515                 520                 525             


Leu Asp Asp Pro Gly Lys Lys Val Lys Lys Pro Ala Pro Pro Gln His 
    530                 535                 540                 


Phe Ser Pro Arg Thr Ala Gln Gly Leu Pro Gly Thr Ser Asn Ser Asn 
545                 550                 555                 560 


Ser Ser Arg Ser Gly Ser Gln Arg Gln Gly Ser Trp Asp Ser Arg Asp 
                565                 570                 575     


Val Val Leu Ser Thr Ser Pro Lys Leu Leu Ala Thr Ala Thr Ala Asn 
            580                 585                 590         


Gly His Gly Leu Lys Gly Asn Asp Glu Ser Ala Gly Leu Asp Arg Arg 
        595                 600                 605             


Gly Ser Ser Ser Ser Ser Pro Glu His Ser Ala Ser Ser Asp Ser Thr 
    610                 615                 620                 


Lys Ala Pro Gln Thr Pro Arg Ser Gly Ala Ala His Leu Cys Asp Ser 
625                 630                 635                 640 


Gln Glu Thr Asn Cys Ser Thr Ala Gly His Ser Lys Thr Pro Pro Ser 
                645                 650                 655     


Gly Ala Asp Ser Lys Thr Val Lys Leu Lys Ser Pro Val Leu Ser Asn 
            660                 665                 670         


Thr Thr Thr Glu Pro Ala Ser Thr Met Ser Pro Pro Pro Ala Lys Lys 
        675                 680                 685             


Leu Ala Leu Ser Ala Lys Lys Ala Ser Thr Leu Trp Arg Ala Thr Gly 
    690                 695                 700                 


Asn Asp Leu Arg Pro Pro Pro Pro Ser Pro Ser Ser Asp Leu Thr His 
705                 710                 715                 720 


Pro Met Lys Thr Ser His Pro Val Val Ala Ser Thr Trp Pro Val His 
                725                 730                 735     


Arg Ala Arg Ala Val Ser Pro Ala Pro Gln Ser Ser Ser Arg Leu Gln 
            740                 745                 750         


Pro Pro Phe Ser Pro His Pro Thr Leu Leu Ser Ser Thr Pro Lys Pro 
        755                 760                 765             


Pro Gly Thr Ser Glu Pro Arg Ser Cys Ser Ser Ile Ser Thr Ala Leu 
    770                 775                 780                 


Pro Gln Val Asn Glu Asp Leu Val Ser Leu Pro His Gln Leu Pro Glu 
785                 790                 795                 800 


Ala Ser Glu Pro Pro Gln Ser Pro Ser Glu Lys Arg Lys Lys Thr Phe 
                805                 810                 815     


Val Gly Glu Pro Gln Arg Leu Gly Ser Glu Thr Arg Leu Pro Gln His 
            820                 825                 830         


Ile Arg Glu Ala Thr Ala Ala Pro His Gly Lys Arg Lys Arg Lys Lys 
        835                 840                 845             


Lys Lys Arg Pro Glu Asp Thr Ala Ala Ser Ala Leu Gln Glu Gly Gln 
    850                 855                 860                 


Thr Gln Arg Gln Pro Gly Ser Pro Met Tyr Arg Arg Glu Gly Gln Ala 
865                 870                 875                 880 


Gln Leu Pro Ala Val Arg Arg Gln Glu Asp Gly Thr Gln Pro Gln Val 
                885                 890                 895     


Asn Gly Gln Gln Val Gly Cys Val Thr Asp Gly His His Ala Ser Ser 
            900                 905                 910         


Arg Lys Arg Arg Arg Lys Gly Ala Glu Gly Leu Gly Glu Glu Gly Gly 
        915                 920                 925             


Leu His Gln Asp Pro Leu Arg His Ser Cys Ser Pro Met Gly Asp Gly 
    930                 935                 940                 


Asp Pro Glu Ala Met Glu Glu Ser Pro Arg Lys Lys Lys Lys Lys Lys 
945                 950                 955                 960 


Arg Lys Gln Glu Thr Gln Arg Ala Val Glu Glu Asp Gly His Leu Lys 
                965                 970                 975     


Cys Pro Arg Ser Ala Lys Pro Gln Asp Ala Val Val Pro Glu Ser Ser 
            980                 985                 990         


Ser Cys Ala Pro Ser Ala Asn Gly  Trp Cys Pro Gly Asp  Arg Met Gly 
        995                 1000                 1005             


Leu Ser  Gln Ala Pro Pro Val  Ser Trp Asn Gly Glu  Arg Glu Ser 
    1010                 1015                 1020             


Asp Val  Val Gln Glu Leu Leu  Lys Tyr Ser Ser Asp  Lys Ala Tyr 
    1025                 1030                 1035             


Gly Arg  Lys Val Leu Thr Trp  Asp Gly Lys Met Ser  Ala Val Ser 
    1040                 1045                 1050             


Gln Asp  Ala Ile Glu Asp Ser  Arg Gln Ala Arg Thr  Glu Thr Val 
    1055                 1060                 1065             


Val Asp  Asp Trp Asp Glu Glu  Phe Asp Arg Gly Lys  Glu Lys Lys 
    1070                 1075                 1080             


Ile Lys  Lys Phe Lys Arg Glu  Lys Arg Arg Asn Phe  Asn Ala Phe 
    1085                 1090                 1095             


Gln Lys  Leu Gln Thr Arg Arg  Asn Phe Trp Ser Val  Thr His Pro 
    1100                 1105                 1110             


Ala Lys  Ala Ala Ser Leu Ser  Tyr Arg Arg 
    1115                 1120             


<210> 45
<211> 712
<212> PRT
<213> Homo sapiens

<400> 45
Met Leu Ala Met Asp Thr Cys Lys His Val Gly Gln Leu Gln Leu Ala 
1               5                   10                  15      


Gln Asp His Ser Ser Leu Asn Pro Gln Lys Trp His Cys Val Asp Cys 
            20                  25                  30          


Asn Thr Thr Glu Ser Ile Trp Ala Cys Leu Ser Cys Ser His Val Ala 
        35                  40                  45              


Cys Gly Arg Tyr Ile Glu Glu His Ala Leu Lys His Phe Gln Glu Ser 
    50                  55                  60                  


Ser His Pro Val Ala Leu Glu Val Asn Glu Met Tyr Val Phe Cys Tyr 
65                  70                  75                  80  


Leu Cys Asp Asp Tyr Val Leu Asn Asp Asn Thr Thr Gly Asp Leu Lys 
                85                  90                  95      


Leu Leu Arg Arg Thr Leu Ser Ala Ile Lys Ser Gln Asn Tyr His Cys 
            100                 105                 110         


Thr Thr Arg Ser Gly Arg Phe Leu Arg Ser Met Gly Thr Gly Asp Asp 
        115                 120                 125             


Ser Tyr Phe Leu His Asp Gly Ala Gln Ser Leu Leu Gln Ser Glu Asp 
    130                 135                 140                 


Gln Leu Tyr Thr Ala Leu Trp His Arg Arg Arg Ile Leu Met Gly Lys 
145                 150                 155                 160 


Ile Phe Arg Thr Trp Phe Glu Gln Ser Pro Ile Gly Arg Lys Lys Gln 
                165                 170                 175     


Glu Glu Pro Phe Gln Glu Lys Ile Val Val Lys Arg Glu Val Lys Lys 
            180                 185                 190         


Arg Arg Gln Glu Leu Glu Tyr Gln Val Lys Ala Glu Leu Glu Ser Met 
        195                 200                 205             


Pro Pro Arg Lys Ser Leu Arg Leu Gln Gly Leu Ala Gln Ser Thr Ile 
    210                 215                 220                 


Ile Glu Ile Val Ser Val Gln Val Pro Ala Gln Thr Pro Ala Ser Pro 
225                 230                 235                 240 


Ala Lys Asp Lys Val Leu Ser Thr Ser Glu Asn Glu Ile Ser Gln Lys 
                245                 250                 255     


Val Ser Asp Ser Ser Val Lys Arg Arg Pro Ile Val Thr Pro Gly Val 
            260                 265                 270         


Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Val Leu 
        275                 280                 285             


Gln Val Leu Ser His Leu Leu Ile Phe Arg Gln Cys Phe Leu Lys Leu 
    290                 295                 300                 


Asp Leu Asn Gln Trp Leu Ala Met Thr Ala Ser Glu Lys Thr Arg Ser 
305                 310                 315                 320 


Cys Lys His Pro Pro Val Thr Asp Thr Val Val Tyr Gln Met Asn Glu 
                325                 330                 335     


Cys Gln Glu Lys Asp Thr Gly Phe Val Cys Ser Arg Gln Ser Ser Leu 
            340                 345                 350         


Ser Ser Gly Leu Ser Gly Gly Ala Ser Lys Gly Arg Lys Met Glu Leu 
        355                 360                 365             


Ile Gln Pro Lys Glu Pro Thr Ser Gln Tyr Ile Ser Leu Cys His Glu 
    370                 375                 380                 


Leu His Thr Leu Phe Gln Val Met Trp Ser Gly Lys Trp Ala Leu Val 
385                 390                 395                 400 


Ser Pro Phe Ala Met Leu His Ser Val Trp Arg Leu Ile Pro Ala Phe 
                405                 410                 415     


Arg Gly Tyr Ala Gln Gln Asp Ala Gln Glu Phe Leu Cys Glu Leu Leu 
            420                 425                 430         


Asp Lys Ile Gln Arg Glu Leu Glu Thr Thr Gly Thr Ser Leu Pro Ala 
        435                 440                 445             


Leu Ile Pro Thr Ser Gln Arg Lys Leu Ile Lys Gln Val Leu Asn Val 
    450                 455                 460                 


Val Asn Asn Ile Phe His Gly Gln Leu Leu Ser Gln Val Thr Cys Leu 
465                 470                 475                 480 


Ala Cys Asp Asn Lys Ser Asn Thr Ile Glu Pro Phe Trp Asp Leu Ser 
                485                 490                 495     


Leu Glu Phe Pro Glu Arg Tyr Gln Cys Ser Gly Lys Asp Ile Ala Ser 
            500                 505                 510         


Gln Pro Cys Leu Val Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu 
        515                 520                 525             


Ala Leu Glu Gly Lys Ile Tyr Val Cys Asp Gln Cys Asn Ser Lys Arg 
    530                 535                 540                 


Arg Arg Phe Ser Ser Lys Pro Val Val Leu Thr Glu Ala Gln Lys Gln 
545                 550                 555                 560 


Leu Met Ile Cys His Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg 
                565                 570                 575     


Phe Arg Trp Ser Gly Arg Asn Asn Arg Glu Lys Ile Gly Val His Val 
            580                 585                 590         


Gly Phe Glu Glu Ile Leu Asn Met Glu Pro Tyr Cys Cys Arg Glu Thr 
        595                 600                 605             


Leu Lys Ser Leu Arg Pro Glu Cys Phe Ile Tyr Asp Leu Ser Ala Val 
    610                 615                 620                 


Val Met His His Gly Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr 
625                 630                 635                 640 


Cys Tyr Asn Ser Glu Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys 
                645                 650                 655     


Leu Ser Met Cys Thr Met Asp Glu Val Cys Lys Ala Gln Ala Tyr Ile 
            660                 665                 670         


Leu Phe Tyr Thr Gln Arg Val Thr Glu Asn Gly His Ser Lys Leu Leu 
        675                 680                 685             


Pro Pro Glu Leu Leu Leu Gly Ser Gln His Pro Asn Glu Asp Ala Asp 
    690                 695                 700                 


Thr Ser Ser Asn Glu Ile Leu Ser 
705                 710         


<210> 46
<211> 1118
<212> PRT
<213> Homo sapiens

<400> 46
Met Pro Ala Val Ala Ser Val Pro Lys Glu Leu Tyr Leu Ser Ser Ser 
1               5                   10                  15      


Leu Lys Asp Leu Asn Lys Lys Thr Glu Val Lys Pro Glu Lys Ile Ser 
            20                  25                  30          


Thr Lys Ser Tyr Val His Ser Ala Leu Lys Ile Phe Lys Thr Ala Glu 
        35                  40                  45              


Glu Cys Arg Leu Asp Arg Asp Glu Glu Arg Ala Tyr Val Leu Tyr Met 
    50                  55                  60                  


Lys Tyr Val Thr Val Tyr Asn Leu Ile Lys Lys Arg Pro Asp Phe Lys 
65                  70                  75                  80  


Gln Gln Gln Asp Tyr Phe His Ser Ile Leu Gly Pro Gly Asn Ile Lys 
                85                  90                  95      


Lys Ala Val Glu Glu Ala Glu Arg Leu Ser Glu Ser Leu Lys Leu Arg 
            100                 105                 110         


Tyr Glu Glu Ala Glu Val Arg Lys Lys Leu Glu Glu Lys Asp Arg Gln 
        115                 120                 125             


Glu Glu Ala Gln Arg Leu Gln Gln Lys Arg Gln Glu Thr Gly Arg Glu 
    130                 135                 140                 


Asp Gly Gly Thr Leu Ala Lys Gly Ser Leu Glu Asn Val Leu Asp Ser 
145                 150                 155                 160 


Lys Asp Lys Thr Gln Lys Ser Asn Gly Glu Lys Asn Glu Lys Cys Glu 
                165                 170                 175     


Thr Lys Glu Lys Gly Ala Ile Thr Ala Lys Glu Leu Tyr Thr Met Met 
            180                 185                 190         


Thr Asp Lys Asn Ile Ser Leu Ile Ile Met Asp Ala Arg Arg Met Gln 
        195                 200                 205             


Asp Tyr Gln Asp Ser Cys Ile Leu His Ser Leu Ser Val Pro Glu Glu 
    210                 215                 220                 


Ala Ile Ser Pro Gly Val Thr Ala Ser Trp Ile Glu Ala His Leu Pro 
225                 230                 235                 240 


Asp Asp Ser Lys Asp Thr Trp Lys Lys Arg Gly Asn Val Glu Tyr Val 
                245                 250                 255     


Val Leu Leu Asp Trp Phe Ser Ser Ala Lys Asp Leu Gln Ile Gly Thr 
            260                 265                 270         


Thr Leu Arg Ser Leu Lys Asp Ala Leu Phe Lys Trp Glu Ser Lys Thr 
        275                 280                 285             


Val Leu Arg Asn Glu Pro Leu Val Leu Glu Gly Gly Tyr Glu Asn Trp 
    290                 295                 300                 


Leu Leu Cys Tyr Pro Gln Tyr Thr Thr Asn Ala Lys Val Thr Pro Pro 
305                 310                 315                 320 


Pro Arg Arg Gln Asn Glu Glu Val Ser Ile Ser Leu Asp Phe Thr Tyr 
                325                 330                 335     


Pro Ser Leu Glu Glu Ser Ile Pro Ser Lys Pro Ala Ala Gln Thr Pro 
            340                 345                 350         


Pro Ala Ser Ile Glu Val Asp Glu Asn Ile Glu Leu Ile Ser Gly Gln 
        355                 360                 365             


Asn Glu Arg Met Gly Pro Leu Asn Ile Ser Thr Pro Val Glu Pro Val 
    370                 375                 380                 


Ala Ala Ser Lys Ser Asp Val Ser Pro Ile Ile Gln Pro Val Pro Ser 
385                 390                 395                 400 


Ile Lys Asn Val Pro Gln Ile Asp Arg Thr Lys Lys Pro Ala Val Lys 
                405                 410                 415     


Leu Pro Glu Glu His Arg Ile Lys Ser Glu Ser Thr Asn His Glu Gln 
            420                 425                 430         


Gln Ser Pro Gln Ser Gly Lys Val Ile Pro Asp Arg Ser Thr Lys Pro 
        435                 440                 445             


Val Val Phe Ser Pro Thr Leu Met Leu Thr Asp Glu Glu Lys Ala Arg 
    450                 455                 460                 


Ile His Ala Glu Thr Ala Leu Leu Met Glu Lys Asn Lys Gln Glu Lys 
465                 470                 475                 480 


Glu Leu Arg Glu Arg Gln Gln Glu Glu Gln Lys Glu Lys Leu Arg Lys 
                485                 490                 495     


Glu Glu Gln Glu Gln Lys Ala Lys Lys Lys Gln Glu Ala Glu Glu Asn 
            500                 505                 510         


Glu Ile Thr Glu Lys Gln Gln Lys Ala Lys Glu Glu Met Glu Lys Lys 
        515                 520                 525             


Glu Ser Glu Gln Ala Lys Lys Glu Asp Lys Glu Thr Ser Ala Lys Arg 
    530                 535                 540                 


Gly Lys Glu Ile Thr Gly Val Lys Arg Gln Ser Lys Ser Glu His Glu 
545                 550                 555                 560 


Thr Ser Asp Ala Lys Lys Ser Val Glu Asp Arg Gly Lys Arg Cys Pro 
                565                 570                 575     


Thr Pro Glu Ile Gln Lys Lys Ser Thr Gly Asp Val Pro His Thr Ser 
            580                 585                 590         


Val Thr Gly Asp Ser Gly Ser Gly Lys Pro Phe Lys Ile Lys Gly Gln 
        595                 600                 605             


Pro Glu Ser Gly Ile Leu Arg Thr Gly Thr Phe Arg Glu Asp Thr Asp 
    610                 615                 620                 


Asp Thr Glu Arg Asn Lys Ala Gln Arg Glu Pro Leu Thr Arg Ala Arg 
625                 630                 635                 640 


Ser Glu Glu Met Gly Arg Ile Val Pro Gly Leu Pro Ser Gly Trp Ala 
                645                 650                 655     


Lys Phe Leu Asp Pro Ile Thr Gly Thr Phe Arg Tyr Tyr His Ser Pro 
            660                 665                 670         


Thr Asn Thr Val His Met Tyr Pro Pro Glu Met Ala Pro Ser Ser Ala 
        675                 680                 685             


Pro Pro Ser Thr Pro Pro Thr His Lys Ala Lys Pro Gln Ile Pro Ala 
    690                 695                 700                 


Glu Arg Asp Arg Glu Pro Ser Lys Leu Lys Arg Ser Tyr Ser Ser Pro 
705                 710                 715                 720 


Asp Ile Thr Gln Ala Ile Gln Glu Glu Glu Lys Arg Lys Pro Thr Val 
                725                 730                 735     


Thr Pro Thr Val Asn Arg Glu Asn Lys Pro Thr Cys Tyr Pro Lys Ala 
            740                 745                 750         


Glu Ile Ser Arg Leu Ser Ala Ser Gln Ile Arg Asn Leu Asn Pro Val 
        755                 760                 765             


Phe Gly Gly Ser Gly Pro Ala Leu Thr Gly Leu Arg Asn Leu Gly Asn 
    770                 775                 780                 


Thr Cys Tyr Met Asn Ser Ile Leu Gln Cys Leu Cys Asn Ala Pro His 
785                 790                 795                 800 


Leu Ala Asp Tyr Phe Asn Arg Asn Cys Tyr Gln Asp Asp Ile Asn Arg 
                805                 810                 815     


Ser Asn Leu Leu Gly His Lys Gly Glu Val Ala Glu Glu Phe Gly Ile 
            820                 825                 830         


Ile Met Lys Ala Leu Trp Thr Gly Gln Tyr Arg Tyr Ile Ser Pro Lys 
        835                 840                 845             


Asp Phe Lys Ile Thr Ile Gly Lys Ile Asn Asp Gln Phe Ala Gly Tyr 
    850                 855                 860                 


Ser Gln Gln Asp Ser Gln Glu Leu Leu Leu Phe Leu Met Asp Gly Leu 
865                 870                 875                 880 


His Glu Asp Leu Asn Lys Ala Asp Asn Arg Lys Arg Tyr Lys Glu Glu 
                885                 890                 895     


Asn Asn Asp His Leu Asp Asp Phe Lys Ala Ala Glu His Ala Trp Gln 
            900                 905                 910         


Lys His Lys Gln Leu Asn Glu Ser Ile Ile Val Ala Leu Phe Gln Gly 
        915                 920                 925             


Gln Phe Lys Ser Thr Val Gln Cys Leu Thr Cys His Lys Lys Ser Arg 
    930                 935                 940                 


Thr Phe Glu Ala Phe Met Tyr Leu Ser Leu Pro Leu Ala Ser Thr Ser 
945                 950                 955                 960 


Lys Cys Thr Leu Gln Asp Cys Leu Arg Leu Phe Ser Lys Glu Glu Lys 
                965                 970                 975     


Leu Thr Asp Asn Asn Arg Phe Tyr Cys Ser His Cys Arg Ala Arg Arg 
            980                 985                 990         


Asp Ser Leu Lys Lys Ile Glu Ile  Trp Lys Leu Pro Pro  Val Leu Leu 
        995                 1000                 1005             


Val His  Leu Lys Arg Phe Ser  Tyr Asp Gly Arg Trp  Lys Gln Lys 
    1010                 1015                 1020             


Leu Gln  Thr Ser Val Asp Phe  Pro Leu Glu Asn Leu  Asp Leu Ser 
    1025                 1030                 1035             


Gln Tyr  Val Ile Gly Pro Lys  Asn Asn Leu Lys Lys  Tyr Asn Leu 
    1040                 1045                 1050             


Phe Ser  Val Ser Asn His Tyr  Gly Gly Leu Asp Gly  Gly His Tyr 
    1055                 1060                 1065             


Thr Ala  Tyr Cys Lys Asn Ala  Ala Arg Gln Arg Trp  Phe Lys Phe 
    1070                 1075                 1080             


Asp Asp  His Glu Val Ser Asp  Ile Ser Val Ser Ser  Val Lys Ser 
    1085                 1090                 1095             


Ser Ala  Ala Tyr Ile Leu Phe  Tyr Thr Ser Leu Gly  Pro Arg Val 
    1100                 1105                 1110             


Thr Asp  Val Ala Thr 
    1115             


<210> 47
<211> 979
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Pro Leu Lys Ile His Gly Pro Ile Arg Ile Arg Ser Met Gln 
1               5                   10                  15      


Thr Gly Ile Thr Lys Trp Lys Glu Gly Ser Phe Glu Ile Val Glu Lys 
            20                  25                  30          


Glu Asn Lys Val Ser Leu Val Val His Tyr Asn Thr Gly Gly Ile Pro 
        35                  40                  45              


Arg Ile Phe Gln Leu Ser His Asn Ile Lys Asn Val Val Leu Arg Pro 
    50                  55                  60                  


Ser Gly Ala Lys Gln Ser Arg Leu Met Leu Thr Leu Gln Asp Asn Ser 
65                  70                  75                  80  


Phe Leu Ser Ile Asp Lys Val Pro Ser Lys Asp Ala Glu Glu Met Arg 
                85                  90                  95      


Leu Phe Leu Asp Ala Val His Gln Asn Arg Leu Pro Ala Ala Met Lys 
            100                 105                 110         


Pro Ser Gln Gly Ser Gly Ser Phe Gly Ala Ile Leu Gly Ser Arg Thr 
        115                 120                 125             


Ser Gln Lys Glu Thr Ser Arg Gln Leu Ser Tyr Ser Asp Asn Gln Ala 
    130                 135                 140                 


Ser Ala Lys Arg Gly Ser Leu Glu Thr Lys Asp Asp Ile Pro Phe Arg 
145                 150                 155                 160 


Lys Val Leu Gly Asn Pro Gly Arg Gly Ser Ile Lys Thr Val Ala Gly 
                165                 170                 175     


Ser Gly Ile Ala Arg Thr Ile Pro Ser Leu Thr Ser Thr Ser Thr Pro 
            180                 185                 190         


Leu Arg Ser Gly Leu Leu Glu Asn Arg Thr Glu Lys Arg Lys Arg Met 
        195                 200                 205             


Ile Ser Thr Gly Ser Glu Leu Asn Glu Asp Tyr Pro Lys Glu Asn Asp 
    210                 215                 220                 


Ser Ser Ser Asn Asn Lys Ala Met Thr Asp Pro Ser Arg Lys Tyr Leu 
225                 230                 235                 240 


Thr Ser Ser Arg Glu Lys Gln Leu Ser Leu Lys Gln Ser Glu Glu Asn 
                245                 250                 255     


Arg Thr Ser Gly Leu Leu Pro Leu Gln Ser Ser Ser Phe Tyr Gly Ser 
            260                 265                 270         


Arg Ala Gly Ser Lys Glu His Ser Ser Gly Gly Thr Asn Leu Asp Arg 
        275                 280                 285             


Thr Asn Val Ser Ser Gln Thr Pro Ser Ala Lys Arg Ser Leu Gly Phe 
    290                 295                 300                 


Leu Pro Gln Pro Val Pro Leu Ser Val Lys Lys Leu Arg Cys Asn Gln 
305                 310                 315                 320 


Asp Tyr Thr Gly Trp Asn Lys Pro Arg Val Pro Leu Ser Ser His Gln 
                325                 330                 335     


Gln Gln Gln Leu Gln Gly Phe Ser Asn Leu Gly Asn Thr Cys Tyr Met 
            340                 345                 350         


Asn Ala Ile Leu Gln Ser Leu Phe Ser Leu Gln Ser Phe Ala Asn Asp 
        355                 360                 365             


Leu Leu Lys Gln Gly Ile Pro Trp Lys Lys Ile Pro Leu Asn Ala Leu 
    370                 375                 380                 


Ile Arg Arg Phe Ala His Leu Leu Val Lys Lys Asp Ile Cys Asn Ser 
385                 390                 395                 400 


Glu Thr Lys Lys Asp Leu Leu Lys Lys Val Lys Asn Ala Ile Ser Ala 
                405                 410                 415     


Thr Ala Glu Arg Phe Ser Gly Tyr Met Gln Asn Asp Ala His Glu Phe 
            420                 425                 430         


Leu Ser Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn 
        435                 440                 445             


Lys Thr Trp Lys Thr Glu Pro Val Ser Gly Glu Glu Asn Ser Pro Asp 
    450                 455                 460                 


Ile Ser Ala Thr Arg Ala Tyr Thr Cys Pro Val Ile Thr Asn Leu Glu 
465                 470                 475                 480 


Phe Glu Val Gln His Ser Ile Ile Cys Lys Ala Cys Gly Glu Ile Ile 
                485                 490                 495     


Pro Lys Arg Glu Gln Phe Asn Asp Leu Ser Ile Asp Leu Pro Arg Arg 
            500                 505                 510         


Lys Lys Pro Leu Pro Pro Arg Ser Ile Gln Asp Ser Leu Asp Leu Phe 
        515                 520                 525             


Phe Arg Ala Glu Glu Leu Glu Tyr Ser Cys Glu Lys Cys Gly Gly Lys 
    530                 535                 540                 


Cys Ala Leu Val Arg His Lys Phe Asn Arg Leu Pro Arg Val Leu Ile 
545                 550                 555                 560 


Leu His Leu Lys Arg Tyr Ser Phe Asn Val Ala Leu Ser Leu Asn Asn 
                565                 570                 575     


Lys Ile Gly Gln Gln Val Ile Ile Pro Arg Tyr Leu Thr Leu Ser Ser 
            580                 585                 590         


His Cys Thr Glu Asn Thr Lys Pro Pro Phe Thr Leu Gly Trp Ser Ala 
        595                 600                 605             


His Met Ala Ile Ser Arg Pro Leu Lys Ala Ser Gln Met Val Asn Ser 
    610                 615                 620                 


Cys Ile Thr Ser Pro Ser Thr Pro Ser Lys Lys Phe Thr Phe Lys Ser 
625                 630                 635                 640 


Lys Ser Ser Leu Ala Leu Cys Leu Asp Ser Asp Ser Glu Asp Glu Leu 
                645                 650                 655     


Lys Arg Ser Val Ala Leu Ser Gln Arg Leu Cys Glu Met Leu Gly Asn 
            660                 665                 670         


Glu Gln Gln Gln Glu Asp Leu Glu Lys Asp Ser Lys Leu Cys Pro Ile 
        675                 680                 685             


Glu Pro Asp Lys Ser Glu Leu Glu Asn Ser Gly Phe Asp Arg Met Ser 
    690                 695                 700                 


Glu Glu Glu Leu Leu Ala Ala Val Leu Glu Ile Ser Lys Arg Asp Ala 
705                 710                 715                 720 


Ser Pro Ser Leu Ser His Glu Asp Asp Asp Lys Pro Thr Ser Ser Pro 
                725                 730                 735     


Asp Thr Gly Phe Ala Glu Asp Asp Ile Gln Glu Met Pro Glu Asn Pro 
            740                 745                 750         


Asp Thr Met Glu Thr Glu Lys Pro Lys Thr Ile Thr Glu Leu Asp Pro 
        755                 760                 765             


Ala Ser Phe Thr Glu Ile Thr Lys Asp Cys Asp Glu Asn Lys Glu Asn 
    770                 775                 780                 


Lys Thr Pro Glu Gly Ser Gln Gly Glu Val Asp Trp Leu Gln Gln Tyr 
785                 790                 795                 800 


Asp Met Glu Arg Glu Arg Glu Glu Gln Glu Leu Gln Gln Ala Leu Ala 
                805                 810                 815     


Gln Ser Leu Gln Glu Gln Glu Ala Trp Glu Gln Lys Glu Asp Asp Asp 
            820                 825                 830         


Leu Lys Arg Ala Thr Glu Leu Ser Leu Gln Glu Phe Asn Asn Ser Phe 
        835                 840                 845             


Val Asp Ala Leu Gly Ser Asp Glu Asp Ser Gly Asn Glu Asp Val Phe 
    850                 855                 860                 


Asp Met Glu Tyr Thr Glu Ala Glu Ala Glu Glu Leu Lys Arg Asn Ala 
865                 870                 875                 880 


Glu Thr Gly Asn Leu Pro His Ser Tyr Arg Leu Ile Ser Val Val Ser 
                885                 890                 895     


His Ile Gly Ser Thr Ser Ser Ser Gly His Tyr Ile Ser Asp Val Tyr 
            900                 905                 910         


Asp Ile Lys Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Glu Val Ser 
        915                 920                 925             


Lys Ile Gln Glu Ala Ala Val Gln Ser Asp Arg Asp Arg Ser Gly Tyr 
    930                 935                 940                 


Ile Phe Phe Tyr Met His Lys Glu Ile Phe Asp Glu Leu Leu Glu Thr 
945                 950                 955                 960 


Glu Lys Asn Ser Gln Ser Leu Ser Thr Glu Val Gly Lys Thr Thr Arg 
                965                 970                 975     


Gln Ala Leu 
            


<210> 48
<211> 530
<212> PRT
<213> Homo sapiens

<400> 48
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Leu Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Val Pro Glu Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His Pro Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp Arg Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 49
<211> 530
<212> PRT
<213> Homo sapiens

<400> 49
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ser Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Gly Lys Val Glu Gly Thr Leu Pro Pro Asn Ala Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ala Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 50
<211> 1684
<212> PRT
<213> Homo sapiens

<400> 50
Met Ser Trp Lys Arg Asn Tyr Phe Ser Gly Gly Arg Gly Ser Val Gln 
1               5                   10                  15      


Gly Met Phe Ala Pro Arg Ser Ser Thr Ser Ile Ala Pro Ser Lys Gly 
            20                  25                  30          


Leu Ser Asn Glu Pro Gly Gln Asn Ser Cys Phe Leu Asn Ser Ala Leu 
        35                  40                  45              


Gln Val Leu Trp His Leu Asp Ile Phe Arg Arg Ser Phe Arg Gln Leu 
    50                  55                  60                  


Thr Thr His Lys Cys Met Gly Asp Ser Cys Ile Phe Cys Ala Leu Lys 
65                  70                  75                  80  


Gly Ile Phe Asn Gln Phe Gln Cys Ser Ser Glu Lys Val Leu Pro Ser 
                85                  90                  95      


Asp Thr Leu Arg Ser Ala Leu Ala Lys Thr Phe Gln Asp Glu Gln Arg 
            100                 105                 110         


Phe Gln Leu Gly Ile Met Asp Asp Ala Ala Glu Cys Phe Glu Asn Leu 
        115                 120                 125             


Leu Met Arg Ile His Phe His Ile Ala Asp Glu Thr Lys Glu Asp Ile 
    130                 135                 140                 


Cys Thr Ala Gln His Cys Ile Ser His Gln Lys Phe Ala Met Thr Leu 
145                 150                 155                 160 


Phe Glu Gln Cys Val Cys Thr Ser Cys Gly Ala Thr Ser Asp Pro Leu 
                165                 170                 175     


Pro Phe Ile Gln Met Val His Tyr Ile Ser Thr Thr Ser Leu Cys Asn 
            180                 185                 190         


Gln Ala Ile Cys Met Leu Glu Arg Arg Glu Lys Pro Ser Pro Ser Met 
        195                 200                 205             


Phe Gly Glu Leu Leu Gln Asn Ala Ser Thr Met Gly Asp Leu Arg Asn 
    210                 215                 220                 


Cys Pro Ser Asn Cys Gly Glu Arg Ile Arg Ile Arg Arg Val Leu Met 
225                 230                 235                 240 


Asn Ala Pro Gln Ile Ile Thr Ile Gly Leu Val Trp Asp Ser Asp His 
                245                 250                 255     


Ser Asp Leu Ala Glu Asp Val Ile His Ser Leu Gly Thr Cys Leu Lys 
            260                 265                 270         


Leu Gly Asp Leu Phe Phe Arg Val Thr Asp Asp Arg Ala Lys Gln Ser 
        275                 280                 285             


Glu Leu Tyr Leu Val Gly Met Ile Cys Tyr Tyr Gly Lys His Tyr Ser 
    290                 295                 300                 


Thr Phe Phe Phe Gln Thr Lys Ile Arg Lys Trp Met Tyr Phe Asp Asp 
305                 310                 315                 320 


Ala His Val Lys Glu Ile Gly Pro Lys Trp Lys Asp Val Val Thr Lys 
                325                 330                 335     


Cys Ile Lys Gly His Tyr Gln Pro Leu Leu Leu Leu Tyr Ala Asp Pro 
            340                 345                 350         


Gln Gly Thr Pro Val Ser Thr Gln Asp Leu Pro Pro Gln Ala Glu Phe 
        355                 360                 365             


Gln Ser Tyr Ser Arg Thr Cys Tyr Asp Ser Glu Asp Ser Gly Arg Glu 
    370                 375                 380                 


Pro Ser Ile Ser Ser Asp Thr Arg Thr Asp Ser Ser Thr Glu Ser Tyr 
385                 390                 395                 400 


Pro Tyr Lys His Ser His His Glu Ser Val Val Ser His Phe Ser Ser 
                405                 410                 415     


Asp Ser Gln Gly Thr Val Ile Tyr Asn Val Glu Asn Asp Ser Met Ser 
            420                 425                 430         


Gln Ser Ser Arg Asp Thr Gly His Leu Thr Asp Ser Glu Cys Asn Gln 
        435                 440                 445             


Lys His Thr Ser Lys Lys Gly Ser Leu Ile Glu Arg Lys Arg Ser Ser 
    450                 455                 460                 


Gly Arg Val Arg Arg Lys Gly Asp Glu Pro Gln Ala Ser Gly Tyr His 
465                 470                 475                 480 


Ser Glu Gly Glu Thr Leu Lys Glu Lys Gln Ala Pro Arg Asn Ala Ser 
                485                 490                 495     


Lys Pro Ser Ser Ser Thr Asn Arg Leu Arg Asp Phe Lys Glu Thr Val 
            500                 505                 510         


Ser Asn Met Ile His Asn Arg Pro Ser Leu Ala Ser Gln Thr Asn Val 
        515                 520                 525             


Gly Ser His Cys Arg Gly Arg Gly Gly Asp Gln Pro Asp Lys Lys Pro 
    530                 535                 540                 


Pro Arg Thr Leu Pro Leu His Ser Arg Asp Trp Glu Ile Glu Ser Thr 
545                 550                 555                 560 


Ser Ser Glu Ser Lys Ser Ser Ser Ser Ser Lys Tyr Arg Pro Thr Trp 
                565                 570                 575     


Arg Pro Lys Arg Glu Ser Leu Asn Ile Asp Ser Ile Phe Ser Lys Asp 
            580                 585                 590         


Lys Arg Lys His Cys Gly Tyr Thr Gln Leu Ser Pro Phe Ser Glu Asp 
        595                 600                 605             


Ser Ala Lys Glu Phe Ile Pro Asp Glu Pro Ser Lys Pro Pro Ser Tyr 
    610                 615                 620                 


Asp Ile Lys Phe Gly Gly Pro Ser Pro Gln Tyr Lys Arg Trp Gly Pro 
625                 630                 635                 640 


Ala Arg Pro Gly Ser His Leu Leu Glu Gln His Pro Arg Leu Ile Gln 
                645                 650                 655     


Arg Met Glu Ser Gly Tyr Glu Ser Ser Glu Arg Asn Ser Ser Ser Pro 
            660                 665                 670         


Val Ser Leu Asp Ala Ala Leu Pro Glu Ser Ser Asn Val Tyr Arg Asp 
        675                 680                 685             


Pro Ser Ala Lys Arg Ser Ala Gly Leu Val Pro Ser Trp Arg His Ile 
    690                 695                 700                 


Pro Lys Ser His Ser Ser Ser Ile Leu Glu Val Asp Ser Thr Ala Ser 
705                 710                 715                 720 


Met Gly Gly Trp Thr Lys Ser Gln Pro Phe Ser Gly Glu Glu Ile Ser 
                725                 730                 735     


Ser Lys Ser Glu Leu Asp Glu Leu Gln Glu Glu Val Ala Arg Arg Ala 
            740                 745                 750         


Gln Glu Gln Glu Leu Arg Arg Lys Arg Glu Lys Glu Leu Glu Ala Ala 
        755                 760                 765             


Lys Gly Phe Asn Pro His Pro Ser Arg Phe Met Asp Leu Asp Glu Leu 
    770                 775                 780                 


Gln Asn Gln Gly Arg Ser Asp Gly Phe Glu Arg Ser Leu Gln Glu Ala 
785                 790                 795                 800 


Glu Ser Val Phe Glu Glu Ser Leu His Leu Glu Gln Lys Gly Asp Cys 
                805                 810                 815     


Ala Ala Ala Leu Ala Leu Cys Asn Glu Ala Ile Ser Lys Leu Arg Leu 
            820                 825                 830         


Ala Leu His Gly Ala Ser Cys Ser Thr His Ser Arg Ala Leu Val Asp 
        835                 840                 845             


Lys Lys Leu Gln Ile Ser Ile Arg Lys Ala Arg Ser Leu Gln Asp Arg 
    850                 855                 860                 


Met Gln Gln Gln Gln Ser Pro Gln Gln Pro Ser Gln Pro Ser Ala Cys 
865                 870                 875                 880 


Leu Pro Thr Gln Ala Gly Thr Leu Ser Gln Pro Thr Ser Glu Gln Pro 
                885                 890                 895     


Ile Pro Leu Gln Val Leu Leu Ser Gln Glu Ala Gln Leu Glu Ser Gly 
            900                 905                 910         


Met Asp Thr Glu Phe Gly Ala Ser Ser Phe Phe His Ser Pro Ala Ser 
        915                 920                 925             


Cys His Glu Ser His Ser Ser Leu Ser Pro Glu Ser Ser Ala Pro Gln 
    930                 935                 940                 


His Ser Ser Pro Ser Arg Ser Ala Leu Lys Leu Leu Thr Ser Val Glu 
945                 950                 955                 960 


Val Asp Asn Ile Glu Pro Ser Ala Phe His Arg Gln Gly Leu Pro Lys 
                965                 970                 975     


Ala Pro Gly Trp Thr Glu Lys Asn Ser His His Ser Trp Glu Pro Leu 
            980                 985                 990         


Asp Ala Pro Glu Gly Lys Leu Gln  Gly Ser Arg Cys Asp  Asn Ser Ser 
        995                 1000                 1005             


Cys Ser  Lys Leu Pro Pro Gln  Glu Gly Arg Gly Ile  Ala Gln Glu 
    1010                 1015                 1020             


Gln Leu  Phe Gln Glu Lys Lys  Asp Pro Ala Asn Pro  Ser Pro Val 
    1025                 1030                 1035             


Met Pro  Gly Ile Ala Thr Ser  Glu Arg Gly Asp Glu  His Ser Leu 
    1040                 1045                 1050             


Gly Cys  Ser Pro Ser Asn Ser  Ser Ala Gln Pro Ser  Leu Pro Leu 
    1055                 1060                 1065             


Tyr Arg  Thr Cys His Pro Ile  Met Pro Val Ala Ser  Ser Phe Val 
    1070                 1075                 1080             


Leu His  Cys Pro Asp Pro Val  Gln Lys Thr Asn Gln  Cys Leu Gln 
    1085                 1090                 1095             


Gly Gln  Ser Leu Lys Thr Ser  Leu Thr Leu Lys Val  Asp Arg Gly 
    1100                 1105                 1110             


Ser Glu  Glu Thr Tyr Arg Pro  Glu Phe Pro Ser Thr  Lys Gly Leu 
    1115                 1120                 1125             


Val Arg  Ser Leu Ala Glu Gln  Phe Gln Arg Met Gln  Gly Val Ser 
    1130                 1135                 1140             


Met Arg  Asp Ser Thr Gly Phe  Lys Asp Arg Ser Leu  Ser Gly Ser 
    1145                 1150                 1155             


Leu Arg  Lys Asn Ser Ser Pro  Ser Asp Ser Lys Pro  Pro Phe Ser 
    1160                 1165                 1170             


Gln Gly  Gln Glu Lys Gly His  Trp Pro Trp Ala Lys  Gln Gln Ser 
    1175                 1180                 1185             


Ser Leu  Glu Gly Gly Asp Arg  Pro Leu Ser Trp Glu  Glu Ser Thr 
    1190                 1195                 1200             


Glu His  Ser Ser Leu Ala Leu  Asn Ser Gly Leu Pro  Asn Gly Glu 
    1205                 1210                 1215             


Thr Ser  Ser Gly Gly Gln Pro  Arg Leu Ala Glu Pro  Asp Ile Tyr 
    1220                 1225                 1230             


Gln Glu  Lys Leu Ser Gln Val  Arg Asp Val Arg Ser  Lys Asp Leu 
    1235                 1240                 1245             


Gly Ser  Ser Thr Asp Leu Gly  Thr Ser Leu Pro Leu  Asp Ser Trp 
    1250                 1255                 1260             


Val Asn  Ile Thr Arg Phe Cys  Asp Ser Gln Leu Lys  His Gly Ala 
    1265                 1270                 1275             


Pro Arg  Pro Gly Met Lys Ser  Ser Pro His Asp Ser  His Thr Cys 
    1280                 1285                 1290             


Val Thr  Tyr Pro Glu Arg Asn  His Ile Leu Leu His  Pro His Trp 
    1295                 1300                 1305             


Asn Gln  Asp Thr Glu Gln Glu  Thr Ser Glu Leu Glu  Ser Leu Tyr 
    1310                 1315                 1320             


Gln Ala  Ser Leu Gln Ala Ser  Gln Ala Gly Cys Ser  Gly Trp Gly 
    1325                 1330                 1335             


Gln Gln  Asp Thr Ala Trp His  Pro Leu Ser Gln Thr  Gly Ser Ala 
    1340                 1345                 1350             


Asp Gly  Met Gly Arg Arg Leu  His Ser Ala His Asp  Pro Gly Leu 
    1355                 1360                 1365             


Ser Lys  Thr Ser Thr Ala Glu  Met Glu His Gly Leu  His Glu Ala 
    1370                 1375                 1380             


Arg Thr  Val Arg Thr Ser Gln  Ala Thr Pro Cys Arg  Gly Leu Ser 
    1385                 1390                 1395             


Arg Glu  Cys Gly Glu Asp Glu  Gln Tyr Ser Ala Glu  Asn Leu Arg 
    1400                 1405                 1410             


Arg Ile  Ser Arg Ser Leu Ser  Gly Thr Val Val Ser  Glu Arg Glu 
    1415                 1420                 1425             


Glu Ala  Pro Val Ser Ser His  Ser Phe Asp Ser Ser  Asn Val Arg 
    1430                 1435                 1440             


Lys Pro  Leu Glu Thr Gly His  Arg Cys Ser Ser Ser  Ser Ser Leu 
    1445                 1450                 1455             


Pro Val  Ile His Asp Pro Ser  Val Phe Leu Leu Gly  Pro Gln Leu 
    1460                 1465                 1470             


Tyr Leu  Pro Gln Pro Gln Phe  Leu Ser Pro Asp Val  Leu Met Pro 
    1475                 1480                 1485             


Thr Met  Ala Gly Glu Pro Asn  Arg Leu Pro Gly Thr  Ser Arg Ser 
    1490                 1495                 1500             


Val Gln  Gln Phe Leu Ala Met  Cys Asp Arg Gly Glu  Thr Ser Gln 
    1505                 1510                 1515             


Gly Ala  Lys Tyr Thr Gly Arg  Thr Leu Asn Tyr Gln  Ser Leu Pro 
    1520                 1525                 1530             


His Arg  Ser Arg Thr Asp Asn  Ser Trp Ala Pro Trp  Ser Glu Thr 
    1535                 1540                 1545             


Asn Gln  His Ile Gly Thr Arg  Phe Leu Thr Thr Pro  Gly Cys Asn 
    1550                 1555                 1560             


Pro Gln  Leu Thr Tyr Thr Ala  Thr Leu Pro Glu Arg  Ser Lys Gly 
    1565                 1570                 1575             


Leu Gln  Val Pro His Thr Gln  Ser Trp Ser Asp Leu  Phe His Ser 
    1580                 1585                 1590             


Pro Ser  His Pro Pro Ile Val  His Pro Val Tyr Pro  Pro Ser Ser 
    1595                 1600                 1605             


Ser Leu  His Val Pro Leu Arg  Ser Ala Trp Asn Ser  Asp Pro Val 
    1610                 1615                 1620             


Pro Gly  Ser Arg Thr Pro Gly  Pro Arg Arg Val Asp  Met Pro Pro 
    1625                 1630                 1635             


Asp Asp  Asp Trp Arg Gln Ser  Ser Tyr Ala Ser His  Ser Gly His 
    1640                 1645                 1650             


Arg Arg  Thr Val Gly Glu Gly  Phe Leu Phe Val Leu  Ser Asp Ala 
    1655                 1660                 1665             


Pro Arg  Arg Glu Gln Ile Arg  Ala Arg Val Leu Gln  His Ser Gln 
    1670                 1675                 1680             


Trp 
    


<210> 51
<211> 565
<212> PRT
<213> Homo sapiens

<400> 51
Met Ser Gly Arg Ser Lys Arg Glu Ser Arg Gly Ser Thr Arg Gly Lys 
1               5                   10                  15      


Arg Glu Ser Glu Ser Arg Gly Ser Ser Gly Arg Val Lys Arg Glu Arg 
            20                  25                  30          


Asp Arg Glu Arg Glu Pro Glu Ala Ala Ser Ser Arg Gly Ser Pro Val 
        35                  40                  45              


Arg Val Lys Arg Glu Phe Glu Pro Ala Ser Ala Arg Glu Ala Pro Ala 
    50                  55                  60                  


Ser Val Val Pro Phe Val Arg Val Lys Arg Glu Arg Glu Val Asp Glu 
65                  70                  75                  80  


Asp Ser Glu Pro Glu Arg Glu Val Arg Ala Lys Asn Gly Arg Val Asp 
                85                  90                  95      


Ser Glu Asp Arg Arg Ser Arg His Cys Pro Tyr Leu Asp Thr Ile Asn 
            100                 105                 110         


Arg Ser Val Leu Asp Phe Asp Phe Glu Lys Leu Cys Ser Ile Ser Leu 
        115                 120                 125             


Ser His Ile Asn Ala Tyr Ala Cys Leu Val Cys Gly Lys Tyr Phe Gln 
    130                 135                 140                 


Gly Arg Gly Leu Lys Ser His Ala Tyr Ile His Ser Val Gln Phe Ser 
145                 150                 155                 160 


His His Val Phe Leu Asn Leu His Thr Leu Lys Phe Tyr Cys Leu Pro 
                165                 170                 175     


Asp Asn Tyr Glu Ile Ile Asp Ser Ser Leu Glu Asp Ile Thr Tyr Val 
            180                 185                 190         


Leu Lys Pro Thr Phe Thr Lys Gln Gln Ile Ala Asn Leu Asp Lys Gln 
        195                 200                 205             


Ala Lys Leu Ser Arg Ala Tyr Asp Gly Thr Thr Tyr Leu Pro Gly Ile 
    210                 215                 220                 


Val Gly Leu Asn Asn Ile Lys Ala Asn Asp Tyr Ala Asn Ala Val Leu 
225                 230                 235                 240 


Gln Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr Phe Leu Glu Glu 
                245                 250                 255     


Asp Asn Tyr Lys Asn Ile Lys Arg Pro Pro Gly Asp Ile Met Phe Leu 
            260                 265                 270         


Leu Val Gln Arg Phe Gly Glu Leu Met Arg Lys Leu Trp Asn Pro Arg 
        275                 280                 285             


Asn Phe Lys Ala His Val Ser Pro His Glu Met Leu Gln Ala Val Val 
    290                 295                 300                 


Leu Cys Ser Lys Lys Thr Phe Gln Ile Thr Lys Gln Gly Asp Gly Val 
305                 310                 315                 320 


Asp Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser Ala Leu Gly Gly 
                325                 330                 335     


Thr Lys Lys Lys Lys Lys Thr Ile Val Thr Asp Val Phe Gln Gly Ser 
            340                 345                 350         


Met Arg Ile Phe Thr Lys Lys Leu Pro His Pro Asp Leu Pro Ala Glu 
        355                 360                 365             


Glu Lys Glu Gln Leu Leu His Asn Asp Glu Tyr Gln Glu Thr Met Val 
    370                 375                 380                 


Glu Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro Thr Ala Pro Leu 
385                 390                 395                 400 


Tyr Lys Asp Glu Lys Glu Gln Leu Ile Ile Pro Gln Val Pro Leu Phe 
                405                 410                 415     


Asn Ile Leu Ala Lys Phe Asn Gly Ile Thr Glu Lys Glu Tyr Lys Thr 
            420                 425                 430         


Tyr Lys Glu Asn Phe Leu Lys Arg Phe Gln Leu Thr Lys Leu Pro Pro 
        435                 440                 445             


Tyr Leu Ile Phe Cys Ile Lys Arg Phe Thr Lys Asn Asn Phe Phe Val 
    450                 455                 460                 


Glu Lys Asn Pro Thr Ile Val Asn Phe Pro Ile Thr Asn Val Asp Leu 
465                 470                 475                 480 


Arg Glu Tyr Leu Ser Glu Glu Val Gln Ala Val His Lys Asn Thr Thr 
                485                 490                 495     


Tyr Asp Leu Ile Ala Asn Ile Val His Asp Gly Lys Pro Ser Glu Gly 
            500                 505                 510         


Ser Tyr Arg Ile His Val Leu His His Gly Thr Gly Lys Trp Tyr Glu 
        515                 520                 525             


Leu Gln Asp Leu Gln Val Thr Asp Ile Leu Pro Gln Met Ile Thr Leu 
    530                 535                 540                 


Ser Glu Ala Tyr Ile Gln Ile Trp Lys Arg Arg Asp Asn Asp Glu Thr 
545                 550                 555                 560 


Asn Gln Gln Gly Ala 
                565 


<210> 52
<211> 1018
<212> PRT
<213> Homo sapiens

<400> 52
Met Asp Lys Ile Leu Glu Ala Val Val Thr Ser Ser Tyr Pro Val Ser 
1               5                   10                  15      


Val Lys Gln Gly Leu Val Arg Arg Val Leu Glu Ala Ala Arg Gln Pro 
            20                  25                  30          


Leu Glu Arg Glu Gln Cys Leu Ala Leu Leu Ala Leu Gly Ala Arg Leu 
        35                  40                  45              


Tyr Val Gly Gly Ala Glu Glu Leu Pro Arg Arg Val Gly Cys Gln Leu 
    50                  55                  60                  


Leu His Val Ala Gly Arg His His Pro Asp Val Phe Ala Glu Phe Phe 
65                  70                  75                  80  


Ser Ala Arg Arg Val Leu Arg Leu Leu Gln Gly Gly Ala Gly Pro Pro 
                85                  90                  95      


Gly Pro Arg Ala Leu Ala Cys Val Gln Leu Gly Leu Gln Leu Leu Pro 
            100                 105                 110         


Glu Gly Pro Ala Ala Asp Glu Val Phe Ala Leu Leu Arg Arg Glu Val 
        115                 120                 125             


Leu Arg Thr Val Cys Glu Arg Pro Gly Pro Ala Ala Cys Ala Gln Val 
    130                 135                 140                 


Ala Arg Leu Leu Ala Arg His Pro Arg Cys Val Pro Asp Gly Pro His 
145                 150                 155                 160 


Arg Leu Leu Phe Cys Gln Gln Leu Val Arg Cys Leu Gly Arg Phe Arg 
                165                 170                 175     


Cys Pro Ala Glu Gly Glu Glu Gly Ala Val Glu Phe Leu Glu Gln Ala 
            180                 185                 190         


Gln Gln Val Ser Gly Leu Leu Ala Gln Leu Trp Arg Ala Gln Pro Ala 
        195                 200                 205             


Ala Ile Leu Pro Cys Leu Lys Glu Leu Phe Ala Val Ile Ser Cys Ala 
    210                 215                 220                 


Glu Glu Glu Pro Pro Ser Ser Ala Leu Ala Ser Val Val Gln His Leu 
225                 230                 235                 240 


Pro Leu Glu Leu Met Asp Gly Val Val Arg Asn Leu Ser Asn Asp Asp 
                245                 250                 255     


Ser Val Thr Asp Ser Gln Met Leu Thr Ala Ile Ser Arg Met Ile Asp 
            260                 265                 270         


Trp Val Ser Trp Pro Leu Gly Lys Asn Ile Asp Lys Trp Ile Ile Ala 
        275                 280                 285             


Leu Leu Lys Gly Leu Ala Ala Val Lys Lys Phe Ser Ile Leu Ile Glu 
    290                 295                 300                 


Val Ser Leu Thr Lys Ile Glu Lys Val Phe Ser Lys Leu Leu Tyr Pro 
305                 310                 315                 320 


Ile Val Arg Gly Ala Ala Leu Ser Val Leu Lys Tyr Met Leu Leu Thr 
                325                 330                 335     


Phe Gln His Ser His Glu Ala Phe His Leu Leu Leu Pro His Ile Pro 
            340                 345                 350         


Pro Met Val Ala Ser Leu Val Lys Glu Asp Ser Asn Ser Gly Thr Ser 
        355                 360                 365             


Cys Leu Glu Gln Leu Ala Glu Leu Val His Cys Met Val Phe Arg Phe 
    370                 375                 380                 


Pro Gly Phe Pro Asp Leu Tyr Glu Pro Val Met Glu Ala Ile Lys Asp 
385                 390                 395                 400 


Leu His Val Pro Asn Glu Asp Arg Ile Lys Gln Leu Leu Gly Gln Asp 
                405                 410                 415     


Ala Trp Thr Ser Gln Lys Ser Glu Leu Ala Gly Phe Tyr Pro Arg Leu 
            420                 425                 430         


Met Ala Lys Ser Asp Thr Gly Lys Ile Gly Leu Ile Asn Leu Gly Asn 
        435                 440                 445             


Thr Cys Tyr Val Asn Ser Ile Leu Gln Ala Leu Phe Met Ala Ser Asp 
    450                 455                 460                 


Phe Arg His Cys Val Leu Arg Leu Thr Glu Asn Asn Ser Gln Pro Leu 
465                 470                 475                 480 


Met Thr Lys Leu Gln Trp Leu Phe Gly Phe Leu Glu His Ser Gln Arg 
                485                 490                 495     


Pro Ala Ile Ser Pro Glu Asn Phe Leu Ser Ala Ser Trp Thr Pro Trp 
            500                 505                 510         


Phe Ser Pro Gly Thr Gln Gln Asp Cys Ser Glu Tyr Leu Lys Tyr Leu 
        515                 520                 525             


Leu Asp Arg Leu His Glu Glu Glu Lys Thr Gly Thr Arg Ile Cys Gln 
    530                 535                 540                 


Lys Leu Lys Gln Ser Ser Ser Pro Ser Pro Pro Glu Glu Pro Pro Ala 
545                 550                 555                 560 


Pro Ser Ser Thr Ser Val Glu Lys Met Phe Gly Gly Lys Ile Val Thr 
                565                 570                 575     


Arg Ile Cys Cys Leu Cys Cys Leu Asn Val Ser Ser Arg Glu Glu Ala 
            580                 585                 590         


Phe Thr Asp Leu Ser Leu Ala Phe Pro Pro Pro Glu Arg Cys Arg Arg 
        595                 600                 605             


Arg Arg Leu Gly Ser Val Met Arg Pro Thr Glu Asp Ile Thr Ala Arg 
    610                 615                 620                 


Glu Leu Pro Pro Pro Thr Ser Ala Gln Gly Pro Gly Arg Val Gly Pro 
625                 630                 635                 640 


Arg Arg Gln Arg Lys His Cys Ile Thr Glu Asp Thr Pro Pro Thr Ser 
                645                 650                 655     


Leu Tyr Ile Glu Gly Leu Asp Ser Lys Glu Ala Gly Gly Gln Ser Ser 
            660                 665                 670         


Gln Glu Glu Arg Ile Glu Arg Glu Glu Glu Gly Lys Glu Glu Arg Thr 
        675                 680                 685             


Glu Lys Glu Glu Val Gly Glu Glu Glu Glu Ser Thr Arg Gly Glu Gly 
    690                 695                 700                 


Glu Arg Glu Lys Glu Glu Glu Val Glu Glu Glu Glu Glu Lys Val Glu 
705                 710                 715                 720 


Lys Glu Thr Glu Lys Glu Ala Glu Gln Glu Lys Glu Glu Asp Ser Leu 
                725                 730                 735     


Gly Ala Gly Thr His Pro Asp Ala Ala Ile Pro Ser Gly Glu Arg Thr 
            740                 745                 750         


Cys Gly Ser Glu Gly Ser Arg Ser Val Leu Asp Leu Val Asn Tyr Phe 
        755                 760                 765             


Leu Ser Pro Glu Lys Leu Thr Ala Glu Asn Arg Tyr Tyr Cys Glu Ser 
    770                 775                 780                 


Cys Ala Ser Leu Gln Asp Ala Glu Lys Val Val Glu Leu Ser Gln Gly 
785                 790                 795                 800 


Pro Cys Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Phe Asp Leu Arg 
                805                 810                 815     


Thr Met Arg Arg Arg Lys Ile Leu Asp Asp Val Ser Ile Pro Leu Leu 
            820                 825                 830         


Leu Arg Leu Pro Leu Ala Gly Gly Arg Gly Gln Ala Tyr Asp Leu Cys 
        835                 840                 845             


Ser Val Val Val His Ser Gly Val Ser Ser Glu Ser Gly His Tyr Tyr 
    850                 855                 860                 


Cys Tyr Ala Arg Glu Gly Ala Ala Arg Pro Ala Ala Ser Leu Gly Thr 
865                 870                 875                 880 


Ala Asp Arg Pro Glu Pro Glu Asn Gln Trp Tyr Leu Phe Asn Asp Thr 
                885                 890                 895     


Arg Val Ser Phe Ser Ser Phe Glu Ser Val Ser Asn Val Thr Ser Phe 
            900                 905                 910         


Phe Pro Lys Asp Thr Ala Tyr Val Leu Phe Tyr Arg Gln Arg Pro Arg 
        915                 920                 925             


Glu Gly Pro Glu Ala Glu Leu Gly Ser Ser Arg Val Arg Thr Glu Pro 
    930                 935                 940                 


Thr Leu His Lys Asp Leu Met Glu Ala Ile Ser Lys Asp Asn Ile Leu 
945                 950                 955                 960 


Tyr Leu Gln Glu Gln Glu Lys Glu Ala Arg Ser Arg Ala Ala Tyr Ile 
                965                 970                 975     


Ser Ala Leu Pro Thr Ser Pro His Trp Gly Arg Gly Phe Asp Glu Asp 
            980                 985                 990         


Lys Asp Glu Asp Glu Gly Ser Pro  Gly Gly Cys Asn Pro  Ala Gly Gly 
        995                 1000                 1005             


Asn Gly  Gly Asp Phe His Arg  Leu Val Phe 
    1010                 1015             


<210> 53
<211> 981
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Glu Gly Gly Ala Ala Asp Leu Asp Thr Gln Arg Ser Asp Ile 
1               5                   10                  15      


Ala Thr Leu Leu Lys Thr Ser Leu Arg Lys Gly Asp Thr Trp Tyr Leu 
            20                  25                  30          


Val Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr Val Gly Phe Asp 
        35                  40                  45              


Ser Trp Asp Lys Tyr Gln Met Gly Asp Gln Asn Val Tyr Pro Gly Pro 
    50                  55                  60                  


Ile Asp Asn Ser Gly Leu Leu Lys Asp Gly Asp Ala Gln Ser Leu Lys 
65                  70                  75                  80  


Glu His Leu Ile Asp Glu Leu Asp Tyr Ile Leu Leu Pro Thr Glu Gly 
                85                  90                  95      


Trp Asn Lys Leu Val Ser Trp Tyr Thr Leu Met Glu Gly Gln Glu Pro 
            100                 105                 110         


Ile Ala Arg Lys Val Val Glu Gln Gly Met Phe Val Lys His Cys Lys 
        115                 120                 125             


Val Glu Val Tyr Leu Thr Glu Leu Lys Leu Cys Glu Asn Gly Asn Met 
    130                 135                 140                 


Asn Asn Val Val Thr Arg Arg Phe Ser Lys Ala Asp Thr Ile Asp Thr 
145                 150                 155                 160 


Ile Glu Lys Glu Ile Arg Lys Ile Phe Ser Ile Pro Asp Glu Lys Glu 
                165                 170                 175     


Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Phe Glu Pro Leu Asn 
            180                 185                 190         


Lys Pro Asp Ser Thr Ile Gln Asp Ala Gly Leu Tyr Gln Gly Gln Val 
        195                 200                 205             


Leu Val Ile Glu Gln Lys Asn Glu Asp Gly Thr Trp Pro Arg Gly Pro 
    210                 215                 220                 


Ser Thr Pro Lys Ser Pro Gly Ala Ser Asn Phe Ser Thr Leu Pro Lys 
225                 230                 235                 240 


Ile Ser Pro Ser Ser Leu Ser Asn Asn Tyr Asn Asn Met Asn Asn Arg 
                245                 250                 255     


Asn Val Lys Asn Ser Asn Tyr Cys Leu Pro Ser Tyr Thr Ala Tyr Lys 
            260                 265                 270         


Asn Tyr Asp Tyr Ser Glu Pro Gly Arg Asn Asn Glu Gln Pro Gly Leu 
        275                 280                 285             


Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Ile 
    290                 295                 300                 


Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu Tyr Phe Leu Asn Asp 
305                 310                 315                 320 


Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro Leu Gly Met Arg Gly 
                325                 330                 335     


Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly 
            340                 345                 350         


Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys Thr Gln Val Gly Arg 
        355                 360                 365             


Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln Asp Cys Gln Glu Leu 
    370                 375                 380                 


Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Arg 
385                 390                 395                 400 


Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp Gly Arg Pro Asp Lys 
                405                 410                 415     


Val Val Ala Glu Glu Ala Trp Glu Asn His Leu Lys Arg Asn Asp Ser 
            420                 425                 430         


Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys 
        435                 440                 445             


Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu 
    450                 455                 460                 


Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr Leu Glu Val Tyr Leu 
465                 470                 475                 480 


Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln Tyr Lys Val Val Val 
                485                 490                 495     


Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr Ala Leu Ser Ala Leu 
            500                 505                 510         


Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr Asp Ile Tyr Asn His 
        515                 520                 525             


Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn Leu Ser Ser Ile Met 
    530                 535                 540                 


Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn Ile Asn Arg Thr Glu 
545                 550                 555                 560 


Asp Thr Glu His Val Ile Ile Pro Val Cys Leu Arg Glu Lys Phe Arg 
                565                 570                 575     


His Ser Ser Tyr Thr His His Thr Gly Ser Ser Leu Phe Gly Gln Pro 
            580                 585                 590         


Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu Asp Lys Leu Tyr Asn 
        595                 600                 605             


Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys Ile Ser Thr Glu Thr 
    610                 615                 620                 


Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys Asp Gln Asn Ile Asn 
625                 630                 635                 640 


Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly Ser Pro Ser Glu Met 
                645                 650                 655     


Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln Asp Gln Glu Leu Pro 
            660                 665                 670         


Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser Val Gly Gly Asp Asn 
        675                 680                 685             


Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr Cys Lys Gly Gln Leu 
    690                 695                 700                 


Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln Phe Asn Asn Leu Gly 
705                 710                 715                 720 


Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr Arg His Ile Arg Phe 
                725                 730                 735     


Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser Phe Leu Ala Leu Asp 
            740                 745                 750         


Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp Glu Asn Ala Ala Glu 
        755                 760                 765             


Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys Pro Pro Lys Lys Pro 
    770                 775                 780                 


Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe Thr Thr Lys Glu Lys 
785                 790                 795                 800 


Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn Cys Lys Glu His Gln 
                805                 810                 815     


Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu Pro Pro Val Leu Val 
            820                 825                 830         


Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr Met Arg Asp Lys Leu 
        835                 840                 845             


Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu Asp Met Ser Glu Phe 
    850                 855                 860                 


Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr Asn Leu Ile Ala Val 
865                 870                 875                 880 


Ser Asn His Tyr Gly Gly Met Gly Gly Gly His Tyr Thr Ala Phe Ala 
                885                 890                 895     


Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Ser Val 
            900                 905                 910         


Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys Ala Ala Tyr Val Leu 
        915                 920                 925             


Phe Tyr Gln Arg Gln Asp Thr Phe Ser Gly Thr Gly Phe Phe Pro Leu 
    930                 935                 940                 


Asp Arg Glu Thr Lys Gly Ala Ser Ala Ala Thr Gly Ile Pro Leu Glu 
945                 950                 955                 960 


Ser Asp Glu Asp Ser Asn Asp Asn Asp Asn Asp Ile Glu Asn Glu Asn 
                965                 970                 975     


Cys Met His Thr Asn 
            980     


<210> 54
<211> 922
<212> PRT
<213> Homo sapiens

<400> 54
Met Ile Ser Leu Lys Val Cys Gly Phe Ile Gln Ile Trp Ser Gln Lys 
1               5                   10                  15      


Thr Gly Met Thr Lys Leu Lys Glu Ala Leu Ile Glu Thr Val Gln Arg 
            20                  25                  30          


Gln Lys Glu Ile Lys Leu Val Val Thr Phe Lys Ser Gly Lys Phe Ile 
        35                  40                  45              


Arg Ile Phe Gln Leu Ser Asn Asn Ile Arg Ser Val Val Leu Arg His 
    50                  55                  60                  


Cys Lys Lys Arg Gln Ser His Leu Arg Leu Thr Leu Lys Asn Asn Val 
65                  70                  75                  80  


Phe Leu Phe Ile Asp Lys Leu Ser Tyr Arg Asp Ala Lys Gln Leu Asn 
                85                  90                  95      


Met Phe Leu Asp Ile Ile His Gln Asn Lys Ser Gln Gln Pro Met Lys 
            100                 105                 110         


Ser Asp Asp Asp Trp Ser Val Phe Glu Ser Arg Asn Met Leu Lys Glu 
        115                 120                 125             


Ile Asp Lys Thr Ser Phe Tyr Ser Ile Cys Asn Lys Pro Ser Tyr Gln 
    130                 135                 140                 


Lys Met Pro Leu Phe Met Ser Lys Ser Pro Thr His Val Lys Lys Gly 
145                 150                 155                 160 


Ile Leu Glu Asn Gln Gly Gly Lys Gly Gln Asn Thr Leu Ser Ser Asp 
                165                 170                 175     


Val Gln Thr Asn Glu Asp Ile Leu Lys Glu Asp Asn Pro Val Pro Asn 
            180                 185                 190         


Lys Lys Tyr Lys Thr Asp Ser Leu Lys Tyr Ile Gln Ser Asn Arg Lys 
        195                 200                 205             


Asn Pro Ser Ser Leu Glu Asp Leu Glu Lys Asp Arg Asp Leu Lys Leu 
    210                 215                 220                 


Gly Pro Ser Phe Asn Thr Asn Cys Asn Gly Asn Pro Asn Leu Asp Glu 
225                 230                 235                 240 


Thr Val Leu Ala Thr Gln Thr Leu Asn Ala Lys Asn Gly Leu Thr Ser 
                245                 250                 255     


Pro Leu Glu Pro Glu His Ser Gln Gly Asp Pro Arg Cys Asn Lys Ala 
            260                 265                 270         


Gln Val Pro Leu Asp Ser His Ser Gln Gln Leu Gln Gln Gly Phe Pro 
        275                 280                 285             


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ala Val Leu Gln Ser Leu Phe 
    290                 295                 300                 


Ala Ile Pro Ser Phe Ala Asp Asp Leu Leu Thr Gln Gly Val Pro Trp 
305                 310                 315                 320 


Glu Tyr Ile Pro Phe Glu Ala Leu Ile Met Thr Leu Thr Gln Leu Leu 
                325                 330                 335     


Ala Leu Lys Asp Phe Cys Ser Thr Lys Ile Lys Arg Glu Leu Leu Gly 
            340                 345                 350         


Asn Val Lys Lys Val Ile Ser Ala Val Ala Glu Ile Phe Ser Gly Asn 
        355                 360                 365             


Met Gln Asn Asp Ala His Glu Phe Leu Gly Gln Cys Leu Asp Gln Leu 
    370                 375                 380                 


Lys Glu Asp Met Glu Lys Leu Asn Ala Thr Leu Asn Thr Gly Lys Glu 
385                 390                 395                 400 


Cys Gly Asp Glu Asn Ser Ser Pro Gln Met His Val Gly Ser Ala Ala 
                405                 410                 415     


Thr Lys Val Phe Val Cys Pro Val Val Ala Asn Phe Glu Phe Glu Leu 
            420                 425                 430         


Gln Leu Ser Leu Ile Cys Lys Ala Cys Gly His Ala Val Leu Lys Val 
        435                 440                 445             


Glu Pro Asn Asn Tyr Leu Ser Ile Asn Leu His Gln Glu Thr Lys Pro 
    450                 455                 460                 


Leu Pro Leu Ser Ile Gln Asn Ser Leu Asp Leu Phe Phe Lys Glu Glu 
465                 470                 475                 480 


Glu Leu Glu Tyr Asn Cys Gln Met Cys Lys Gln Lys Ser Cys Val Ala 
                485                 490                 495     


Arg His Thr Phe Ser Arg Leu Ser Arg Val Leu Ile Ile His Leu Lys 
            500                 505                 510         


Arg Tyr Ser Phe Asn Asn Ala Trp Leu Leu Val Lys Asn Asn Glu Gln 
        515                 520                 525             


Val Tyr Ile Pro Lys Ser Leu Ser Leu Ser Ser Tyr Cys Asn Glu Ser 
    530                 535                 540                 


Thr Lys Pro Pro Leu Pro Leu Ser Ser Ser Ala Pro Val Gly Lys Cys 
545                 550                 555                 560 


Glu Val Leu Glu Val Ser Gln Glu Met Ile Ser Glu Ile Asn Ser Pro 
                565                 570                 575     


Leu Thr Pro Ser Met Lys Leu Thr Ser Glu Ser Ser Asp Ser Leu Val 
            580                 585                 590         


Leu Pro Val Glu Pro Asp Lys Asn Ala Asp Leu Gln Arg Phe Gln Arg 
        595                 600                 605             


Asp Cys Gly Asp Ala Ser Gln Glu Gln His Gln Arg Asp Leu Glu Asn 
    610                 615                 620                 


Gly Ser Ala Leu Glu Ser Glu Leu Val His Phe Arg Asp Arg Ala Ile 
625                 630                 635                 640 


Gly Glu Lys Glu Leu Pro Val Ala Asp Ser Leu Met Asp Gln Gly Asp 
                645                 650                 655     


Ile Ser Leu Pro Val Met Tyr Glu Asp Gly Gly Lys Leu Ile Ser Ser 
            660                 665                 670         


Pro Asp Thr Arg Leu Val Glu Val His Leu Gln Glu Val Pro Gln His 
        675                 680                 685             


Pro Glu Leu Gln Lys Tyr Glu Lys Thr Asn Thr Phe Val Glu Phe Asn 
    690                 695                 700                 


Phe Asp Ser Val Thr Glu Ser Thr Asn Gly Phe Tyr Asp Cys Lys Glu 
705                 710                 715                 720 


Asn Arg Ile Pro Glu Gly Ser Gln Gly Met Ala Glu Gln Leu Gln Gln 
                725                 730                 735     


Cys Ile Glu Glu Ser Ile Ile Asp Glu Phe Leu Gln Gln Ala Pro Pro 
            740                 745                 750         


Pro Gly Val Arg Lys Leu Asp Ala Gln Glu His Thr Glu Glu Thr Leu 
        755                 760                 765             


Asn Gln Ser Thr Glu Leu Arg Leu Gln Lys Ala Asp Leu Asn His Leu 
    770                 775                 780                 


Gly Ala Leu Gly Ser Asp Asn Pro Gly Asn Lys Asn Ile Leu Asp Ala 
785                 790                 795                 800 


Glu Asn Thr Arg Gly Glu Ala Lys Glu Leu Thr Arg Asn Val Lys Met 
                805                 810                 815     


Gly Asp Pro Leu Gln Ala Tyr Arg Leu Ile Ser Val Val Ser His Ile 
            820                 825                 830         


Gly Ser Ser Pro Asn Ser Gly His Tyr Ile Ser Asp Val Tyr Asp Phe 
        835                 840                 845             


Gln Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Cys Val Ser Glu Ile 
    850                 855                 860                 


Ser Glu Thr Lys Met Gln Glu Ala Arg Leu His Ser Gly Tyr Ile Phe 
865                 870                 875                 880 


Phe Tyr Met His Asn Gly Ile Phe Glu Glu Leu Leu Arg Lys Ala Glu 
                885                 890                 895     


Asn Ser Arg Leu Pro Ser Thr Gln Ala Gly Val Ile Pro Gln Gly Glu 
            900                 905                 910         


Tyr Glu Gly Asp Ser Leu Tyr Arg Pro Ala 
        915                 920         


<210> 55
<211> 1406
<212> PRT
<213> Homo sapiens

<400> 55
Met Asp Met Val Glu Asn Ala Asp Ser Leu Gln Ala Gln Glu Arg Lys 
1               5                   10                  15      


Asp Ile Leu Met Lys Tyr Asp Lys Gly His Arg Ala Gly Leu Pro Glu 
            20                  25                  30          


Asp Lys Gly Pro Glu Pro Val Gly Ile Asn Ser Ser Ile Asp Arg Phe 
        35                  40                  45              


Gly Ile Leu His Glu Thr Glu Leu Pro Pro Val Thr Ala Arg Glu Ala 
    50                  55                  60                  


Lys Lys Ile Arg Arg Glu Met Thr Arg Thr Ser Lys Trp Met Glu Met 
65                  70                  75                  80  


Leu Gly Glu Trp Glu Thr Tyr Lys His Ser Ser Lys Leu Ile Asp Arg 
                85                  90                  95      


Val Tyr Lys Gly Ile Pro Met Asn Ile Arg Gly Pro Val Trp Ser Val 
            100                 105                 110         


Leu Leu Asn Ile Gln Glu Ile Lys Leu Lys Asn Pro Gly Arg Tyr Gln 
        115                 120                 125             


Ile Met Lys Glu Arg Gly Lys Arg Ser Ser Glu His Ile His His Ile 
    130                 135                 140                 


Asp Leu Asp Val Arg Thr Thr Leu Arg Asn His Val Phe Phe Arg Asp 
145                 150                 155                 160 


Arg Tyr Gly Ala Lys Gln Arg Glu Leu Phe Tyr Ile Leu Leu Ala Tyr 
                165                 170                 175     


Ser Glu Tyr Asn Pro Glu Val Gly Tyr Cys Arg Asp Leu Ser His Ile 
            180                 185                 190         


Thr Ala Leu Phe Leu Leu Tyr Leu Pro Glu Glu Asp Ala Phe Trp Ala 
        195                 200                 205             


Leu Val Gln Leu Leu Ala Ser Glu Arg His Ser Leu Pro Gly Phe His 
    210                 215                 220                 


Ser Pro Asn Gly Gly Thr Val Gln Gly Leu Gln Asp Gln Gln Glu His 
225                 230                 235                 240 


Val Val Pro Lys Ser Gln Pro Lys Thr Met Trp His Gln Asp Lys Glu 
                245                 250                 255     


Gly Leu Cys Gly Gln Cys Ala Ser Leu Gly Cys Leu Leu Arg Asn Leu 
            260                 265                 270         


Ile Asp Gly Ile Ser Leu Gly Leu Thr Leu Arg Leu Trp Asp Val Tyr 
        275                 280                 285             


Leu Val Glu Gly Glu Gln Val Leu Met Pro Ile Thr Ser Ile Ala Leu 
    290                 295                 300                 


Lys Val Gln Gln Lys Arg Leu Met Lys Thr Ser Arg Cys Gly Leu Trp 
305                 310                 315                 320 


Ala Arg Leu Arg Asn Gln Phe Phe Asp Thr Trp Ala Met Asn Asp Asp 
                325                 330                 335     


Thr Val Leu Lys His Leu Arg Ala Ser Thr Lys Lys Leu Thr Arg Lys 
            340                 345                 350         


Gln Gly Asp Leu Pro Pro Pro Ala Lys Arg Glu Gln Gly Ser Leu Ala 
        355                 360                 365             


Pro Arg Pro Val Pro Ala Ser Arg Gly Gly Lys Thr Leu Cys Lys Gly 
    370                 375                 380                 


Tyr Arg Gln Ala Pro Pro Gly Pro Pro Ala Gln Phe Gln Arg Pro Ile 
385                 390                 395                 400 


Cys Ser Ala Ser Pro Pro Trp Ala Ser Arg Phe Ser Thr Pro Cys Pro 
                405                 410                 415     


Gly Gly Ala Val Arg Glu Asp Thr Tyr Pro Val Gly Thr Gln Gly Val 
            420                 425                 430         


Pro Ser Leu Ala Leu Ala Gln Gly Gly Pro Gln Gly Ser Trp Arg Phe 
        435                 440                 445             


Leu Glu Trp Lys Ser Met Pro Arg Leu Pro Thr Asp Leu Asp Ile Gly 
    450                 455                 460                 


Gly Pro Trp Phe Pro His Tyr Asp Phe Glu Trp Ser Cys Trp Val Arg 
465                 470                 475                 480 


Ala Ile Ser Gln Glu Asp Gln Leu Ala Thr Cys Trp Gln Ala Glu His 
                485                 490                 495     


Cys Gly Glu Val His Asn Lys Asp Met Ser Trp Pro Glu Glu Met Ser 
            500                 505                 510         


Phe Thr Ala Asn Ser Ser Lys Ile Asp Arg Gln Lys Val Pro Thr Glu 
        515                 520                 525             


Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 
    530                 535                 540                 


Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe 
545                 550                 555                 560 


Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly 
                565                 570                 575     


Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu 
            580                 585                 590         


Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr 
        595                 600                 605             


Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser 
    610                 615                 620                 


Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 
625                 630                 635                 640 


Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg 
                645                 650                 655     


Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg 
            660                 665                 670         


Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln 
        675                 680                 685             


Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Phe 
    690                 695                 700                 


Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu 
705                 710                 715                 720 


Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu 
                725                 730                 735     


Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg 
            740                 745                 750         


Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His 
        755                 760                 765             


Asp Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu 
    770                 775                 780                 


Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser 
785                 790                 795                 800 


Pro Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro 
                805                 810                 815     


Ser Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys 
            820                 825                 830         


Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly 
        835                 840                 845             


Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser 
    850                 855                 860                 


Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys 
865                 870                 875                 880 


Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro 
                885                 890                 895     


Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg 
            900                 905                 910         


Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala 
        915                 920                 925             


Arg Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp 
    930                 935                 940                 


Asn Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys 
945                 950                 955                 960 


Asp Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly 
                965                 970                 975     


Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr 
            980                 985                 990         


Ile Ala Val Asp Trp His Pro Thr  Ala Leu His Leu Arg  Tyr Gln Thr 
        995                 1000                 1005             


Ser Gln  Glu Arg Val Val Asp  Lys His Glu Ser Val  Glu Gln Ser 
    1010                 1015                 1020             


Arg Arg  Ala Gln Ala Glu Pro  Ile Asn Leu Asp Ser  Cys Leu Arg 
    1025                 1030                 1035             


Ala Phe  Thr Ser Glu Glu Glu  Leu Gly Glu Ser Glu  Met Tyr Tyr 
    1040                 1045                 1050             


Cys Ser  Lys Cys Lys Thr His  Cys Leu Ala Thr Lys  Lys Leu Asp 
    1055                 1060                 1065             


Leu Trp  Arg Leu Pro Pro Phe  Leu Ile Ile His Leu  Lys Arg Phe 
    1070                 1075                 1080             


Gln Phe  Val Asn Asp Gln Trp  Ile Lys Ser Gln Lys  Ile Val Arg 
    1085                 1090                 1095             


Phe Leu  Arg Glu Ser Phe Asp  Pro Ser Ala Phe Leu  Val Pro Arg 
    1100                 1105                 1110             


Asp Pro  Ala Leu Cys Gln His  Lys Pro Leu Thr Pro  Gln Gly Asp 
    1115                 1120                 1125             


Glu Leu  Ser Lys Pro Arg Ile  Leu Ala Arg Glu Val  Lys Lys Val 
    1130                 1135                 1140             


Asp Ala  Gln Ser Ser Ala Gly  Lys Glu Asp Met Leu  Leu Ser Lys 
    1145                 1150                 1155             


Ser Pro  Ser Ser Leu Ser Ala  Asn Ile Ser Ser Ser  Pro Lys Gly 
    1160                 1165                 1170             


Ser Pro  Ser Ser Ser Arg Lys  Ser Gly Thr Ser Cys  Pro Ser Ser 
    1175                 1180                 1185             


Lys Asn  Ser Ser Pro Asn Ser  Ser Pro Arg Thr Leu  Gly Arg Ser 
    1190                 1195                 1200             


Lys Gly  Arg Leu Arg Leu Pro  Gln Ile Gly Ser Lys  Asn Lys Pro 
    1205                 1210                 1215             


Ser Ser  Ser Lys Lys Asn Leu  Asp Ala Ser Lys Glu  Asn Gly Ala 
    1220                 1225                 1230             


Gly Gln  Ile Cys Glu Leu Ala  Asp Ala Leu Ser Arg  Gly His Met 
    1235                 1240                 1245             


Arg Gly  Gly Ser Gln Pro Glu  Leu Val Thr Pro Gln  Asp His Glu 
    1250                 1255                 1260             


Val Ala  Leu Ala Asn Gly Phe  Leu Tyr Glu His Glu  Ala Cys Gly 
    1265                 1270                 1275             


Asn Gly  Cys Gly Asp Gly Tyr  Ser Asn Gly Gln Leu  Gly Asn His 
    1280                 1285                 1290             


Ser Glu  Glu Asp Ser Thr Asp  Asp Gln Arg Glu Asp  Thr His Ile 
    1295                 1300                 1305             


Lys Pro  Ile Tyr Asn Leu Tyr  Ala Ile Ser Cys His  Ser Gly Ile 
    1310                 1315                 1320             


Leu Ser  Gly Gly His Tyr Ile  Thr Tyr Ala Lys Asn  Pro Asn Cys 
    1325                 1330                 1335             


Lys Trp  Tyr Cys Tyr Asn Asp  Ser Ser Cys Glu Glu  Leu His Pro 
    1340                 1345                 1350             


Asp Glu  Ile Asp Thr Asp Ser  Ala Tyr Ile Leu Phe  Tyr Glu Gln 
    1355                 1360                 1365             


Gln Gly  Ile Asp Tyr Ala Gln  Phe Leu Pro Lys Ile  Asp Gly Lys 
    1370                 1375                 1380             


Lys Met  Ala Asp Thr Ser Ser  Thr Asp Glu Asp Ser  Glu Ser Asp 
    1385                 1390                 1395             


Tyr Glu  Lys Tyr Ser Met Leu  Gln 
    1400                 1405     


<210> 56
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Trp Val Lys Phe Leu Arg Lys Pro Gly Gly Asn Leu Gly Lys 
1               5                   10                  15      


Val Tyr Gln Pro Gly Ser Met Leu Ser Leu Ala Pro Thr Lys Gly Leu 
            20                  25                  30          


Leu Asn Glu Pro Gly Gln Asn Ser Cys Phe Leu Asn Ser Ala Val Gln 
        35                  40                  45              


Val Leu Trp Gln Leu Asp Ile Phe Arg Arg Ser Leu Arg Val Leu Thr 
    50                  55                  60                  


Gly His Val Cys Gln Gly Asp Ala Cys Ile Phe Cys Ala Leu Lys Thr 
65                  70                  75                  80  


Ile Phe Ala Gln Phe Gln His Ser Arg Glu Lys Ala Leu Pro Ser Asp 
                85                  90                  95      


Asn Ile Arg His Ala Leu Ala Glu Ser Phe Lys Asp Glu Gln Arg Phe 
            100                 105                 110         


Gln Leu Gly Leu Met Asp Asp Ala Ala Glu Cys Phe Glu Asn Met Leu 
        115                 120                 125             


Glu Arg Ile His Phe His Ile Val Pro Ser Arg Asp Ala Asp Met Cys 
    130                 135                 140                 


Thr Ser Lys Ser Cys Ile Thr His Gln Lys Phe Ala Met Thr Leu Tyr 
145                 150                 155                 160 


Glu Gln Cys Val Cys Arg Ser Cys Gly Ala Ser Ser Asp Pro Leu Pro 
                165                 170                 175     


Phe Thr Glu Phe Val Arg Tyr Ile Ser Thr Thr Ala Leu Cys Asn Glu 
            180                 185                 190         


Val Glu Arg Met Leu Glu Arg His Glu Arg Phe Lys Pro Glu Met Phe 
        195                 200                 205             


Ala Glu Leu Leu Gln Ala Ala Asn Thr Thr Asp Asp Tyr Arg Lys Cys 
    210                 215                 220                 


Pro Ser Asn Cys Gly Gln Lys Ile Lys Ile Arg Arg Val Leu Met Asn 
225                 230                 235                 240 


Cys Pro Glu Ile Val Thr Ile Gly Leu Val Trp Asp Ser Glu His Ser 
                245                 250                 255     


Asp Leu Thr Glu Ala Val Val Arg Asn Leu Ala Thr His Leu Tyr Leu 
            260                 265                 270         


Pro Gly Leu Phe Tyr Arg Val Thr Asp Glu Asn Ala Lys Asn Ser Glu 
        275                 280                 285             


Leu Asn Leu Val Gly Met Ile Cys Tyr Thr Ser Gln His Tyr Cys Ala 
    290                 295                 300                 


Phe Ala Phe His Thr Lys Ser Ser Lys Trp Val Phe Phe Asp Asp Ala 
305                 310                 315                 320 


Asn Val Lys Glu Ile Gly Thr Arg Trp Lys Asp Val Val Ser Lys Cys 
                325                 330                 335     


Ile Arg Cys His Phe Gln Pro Leu Leu Leu Phe Tyr Ala Asn Pro Asp 
            340                 345                 350         


Gly Thr Ala Val Ser Thr Glu Asp Ala Leu Arg Gln Val Ile Ser Trp 
        355                 360                 365             


Ser His Tyr Lys Ser Val Ala Glu Asn Met Gly Cys Glu Lys Pro Val 
    370                 375                 380                 


Ile His Lys Ser Asp Asn Leu Lys Glu Asn Gly Phe Gly Asp Gln Ala 
385                 390                 395                 400 


Lys Gln Arg Glu Asn Gln Lys Phe Pro Thr Asp Asn Ile Ser Ser Ser 
                405                 410                 415     


Asn Arg Ser His Ser His Thr Gly Val Gly Lys Gly Pro Ala Lys Leu 
            420                 425                 430         


Ser His Ile Asp Gln Arg Glu Lys Ile Lys Asp Ile Ser Arg Glu Cys 
        435                 440                 445             


Ala Leu Lys Ala Ile Glu Gln Lys Asn Leu Leu Ser Ser Gln Arg Lys 
    450                 455                 460                 


Asp Leu Glu Lys Gly Gln Arg Lys Asp Leu Gly Arg His Arg Asp Leu 
465                 470                 475                 480 


Val Asp Glu Asp Leu Ser His Phe Gln Ser Gly Ser Pro Pro Ala Pro 
                485                 490                 495     


Asn Gly Phe Lys Gln His Gly Asn Pro His Leu Tyr His Ser Gln Gly 
            500                 505                 510         


Lys Gly Ser Tyr Lys His Asp Arg Val Val Pro Gln Ser Arg Ala Ser 
        515                 520                 525             


Ala Gln Ile Ile Ser Ser Ser Lys Ser Gln Ile Leu Ala Pro Gly Glu 
    530                 535                 540                 


Lys Ile Thr Gly Lys Val Lys Ser Asp Asn Gly Thr Gly Tyr Asp Thr 
545                 550                 555                 560 


Asp Ser Ser Gln Asp Ser Arg Asp Arg Gly Asn Ser Cys Asp Ser Ser 
                565                 570                 575     


Ser Lys Ser Arg Asn Arg Gly Trp Lys Pro Met Arg Glu Thr Leu Asn 
            580                 585                 590         


Val Asp Ser Ile Phe Ser Glu Ser Glu Lys Arg Gln His Ser Pro Arg 
        595                 600                 605             


His Lys Pro Asn Ile Ser Asn Lys Pro Lys Ser Ser Lys Asp Pro Ser 
    610                 615                 620                 


Phe Ser Asn Trp Pro Lys Glu Asn Pro Lys Gln Lys Gly Leu Met Thr 
625                 630                 635                 640 


Ile Tyr Glu Asp Glu Met Lys Gln Glu Ile Gly Ser Arg Ser Ser Leu 
                645                 650                 655     


Glu Ser Asn Gly Lys Gly Ala Glu Lys Asn Lys Gly Leu Val Glu Gly 
            660                 665                 670         


Lys Val His Gly Asp Asn Trp Gln Met Gln Arg Thr Glu Ser Gly Tyr 
        675                 680                 685             


Glu Ser Ser Asp His Ile Ser Asn Gly Ser Thr Asn Leu Asp Ser Pro 
    690                 695                 700                 


Val Ile Asp Gly Asn Gly Thr Val Met Asp Ile Ser Gly Val Lys Glu 
705                 710                 715                 720 


Thr Val Cys Phe Ser Asp Gln Ile Thr Thr Ser Asn Leu Asn Lys Glu 
                725                 730                 735     


Arg Gly Asp Cys Thr Ser Leu Gln Ser Gln His His Leu Glu Gly Phe 
            740                 745                 750         


Arg Lys Glu Leu Arg Asn Leu Glu Ala Gly Tyr Lys Ser His Glu Phe 
        755                 760                 765             


His Pro Glu Ser His Leu Gln Ile Lys Asn His Leu Ile Lys Arg Ser 
    770                 775                 780                 


His Val His Glu Asp Asn Gly Lys Leu Phe Pro Ser Ser Ser Leu Gln 
785                 790                 795                 800 


Ile Pro Lys Asp His Asn Ala Arg Glu His Ile His Gln Ser Asp Glu 
                805                 810                 815     


Gln Lys Leu Glu Lys Pro Asn Glu Cys Lys Phe Ser Glu Trp Leu Asn 
            820                 825                 830         


Ile Glu Asn Ser Glu Arg Thr Gly Leu Pro Phe His Val Asp Asn Ser 
        835                 840                 845             


Ala Ser Gly Lys Arg Val Asn Ser Asn Glu Pro Ser Ser Leu Trp Ser 
    850                 855                 860                 


Ser His Leu Arg Thr Val Gly Leu Lys Pro Glu Thr Ala Pro Leu Ile 
865                 870                 875                 880 


Gln Gln Gln Asn Ile Met Asp Gln Cys Tyr Phe Glu Asn Ser Leu Ser 
                885                 890                 895     


Thr Glu Cys Ile Ile Arg Ser Ala Ser Arg Ser Asp Gly Cys Gln Met 
            900                 905                 910         


Pro Lys Leu Phe Cys Gln Asn Leu Pro Pro Pro Leu Pro Pro Lys Lys 
        915                 920                 925             


Tyr Ala Ile Thr Ser Val Pro Gln Ser Glu Lys Ser Glu Ser Thr Pro 
    930                 935                 940                 


Asp Val Lys Leu Thr Glu Val Phe Lys Ala Thr Ser His Leu Pro Lys 
945                 950                 955                 960 


His Ser Leu Ser Thr Ala Ser Glu Pro Ser Leu Glu Val Ser Thr His 
                965                 970                 975     


Met Asn Asp Glu Arg His Lys Glu Thr Phe Gln Val Arg Glu Cys Phe 
            980                 985                 990         


Gly Asn Thr Pro Asn Cys Pro Ser  Ser Ser Ser Thr Asn  Asp Phe Gln 
        995                 1000                 1005             


Ala Asn  Ser Gly Ala Ile Asp  Ala Phe Cys Gln Pro  Glu Leu Asp 
    1010                 1015                 1020             


Ser Ile  Ser Thr Cys Pro Asn  Glu Thr Val Ser Leu  Thr Thr Tyr 
    1025                 1030                 1035             


Phe Ser  Val Asp Ser Cys Met  Thr Asp Thr Tyr Arg  Leu Lys Tyr 
    1040                 1045                 1050             


His Gln  Arg Pro Lys Leu Ser  Phe Pro Glu Ser Ser  Gly Phe Cys 
    1055                 1060                 1065             


Asn Asn  Ser Leu Ser 
    1070             


<210> 57
<211> 530
<212> PRT
<213> Homo sapiens

<400> 57
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 58
<211> 858
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
625                 630                 635                 640 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                645                 650                 655     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            660                 665                 670         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        675                 680                 685             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    690                 695                 700                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
705                 710                 715                 720 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                725                 730                 735     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            740                 745                 750         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        755                 760                 765             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    770                 775                 780                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
785                 790                 795                 800 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                805                 810                 815     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            820                 825                 830         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        835                 840                 845             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser 
    850                 855             


<210> 59
<211> 1055
<212> PRT
<213> Homo sapiens

<400> 59
Met Thr Val Glu Gln Asn Val Leu Gln Gln Ser Ala Ala Gln Lys His 
1               5                   10                  15      


Gln Gln Thr Phe Leu Asn Gln Leu Arg Glu Ile Thr Gly Ile Asn Asp 
            20                  25                  30          


Thr Gln Ile Leu Gln Gln Ala Leu Lys Asp Ser Asn Gly Asn Leu Glu 
        35                  40                  45              


Leu Ala Val Ala Phe Leu Thr Ala Lys Asn Ala Lys Thr Pro Gln Gln 
    50                  55                  60                  


Glu Glu Thr Thr Tyr Tyr Gln Thr Ala Leu Pro Gly Asn Asp Arg Tyr 
65                  70                  75                  80  


Ile Ser Val Gly Ser Gln Ala Asp Thr Asn Val Ile Asp Leu Thr Gly 
                85                  90                  95      


Asp Asp Lys Asp Asp Leu Gln Arg Ala Ile Ala Leu Ser Leu Ala Glu 
            100                 105                 110         


Ser Asn Arg Ala Phe Arg Glu Thr Gly Ile Thr Asp Glu Glu Gln Ala 
        115                 120                 125             


Ile Ser Arg Val Leu Glu Ala Ser Ile Ala Glu Asn Lys Ala Cys Leu 
    130                 135                 140                 


Lys Arg Thr Pro Thr Glu Val Trp Arg Asp Ser Arg Asn Pro Tyr Asp 
145                 150                 155                 160 


Arg Lys Arg Gln Asp Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn 
                165                 170                 175     


Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu 
            180                 185                 190         


Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp 
        195                 200                 205             


Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu 
    210                 215                 220                 


Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val 
225                 230                 235                 240 


Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn 
                245                 250                 255     


Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp 
            260                 265                 270         


Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu 
        275                 280                 285             


Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu 
    290                 295                 300                 


Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe 
305                 310                 315                 320 


Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys 
                325                 330                 335     


Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu 
            340                 345                 350         


Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro 
        355                 360                 365             


Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly 
    370                 375                 380                 


Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr 
385                 390                 395                 400 


Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg 
                405                 410                 415     


Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg 
            420                 425                 430         


Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu 
        435                 440                 445             


Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val 
    450                 455                 460                 


Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly 
465                 470                 475                 480 


Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala 
                485                 490                 495     


Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile 
            500                 505                 510         


Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro 
        515                 520                 525             


Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile Thr Glu Glu Glu 
    530                 535                 540                 


Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu 
545                 550                 555                 560 


Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr 
                565                 570                 575     


Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg 
            580                 585                 590         


Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn Ala Gly His Tyr 
        595                 600                 605             


Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn 
    610                 615                 620                 


Asp Ile Ala Val Thr Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser 
625                 630                 635                 640 


Phe Gly Gly Tyr Arg Asn Ala Ser Ala Tyr Cys Leu Met Tyr Ile Asn 
                645                 650                 655     


Asp Lys Ala Gln Phe Leu Ile Gln Glu Glu Phe Asn Lys Glu Thr Gly 
            660                 665                 670         


Gln Pro Leu Val Gly Ile Glu Thr Leu Pro Pro Asp Leu Arg Asp Phe 
        675                 680                 685             


Val Glu Glu Asp Asn Gln Arg Phe Glu Lys Glu Leu Glu Glu Trp Asp 
    690                 695                 700                 


Ala Gln Leu Ala Gln Lys Ala Leu Gln Glu Lys Leu Leu Ala Ser Gln 
705                 710                 715                 720 


Lys Leu Arg Glu Ser Glu Thr Ser Val Thr Thr Ala Gln Ala Ala Gly 
                725                 730                 735     


Asp Pro Glu Tyr Leu Glu Gln Pro Ser Arg Ser Asp Phe Ser Lys His 
            740                 745                 750         


Leu Lys Glu Glu Thr Ile Gln Ile Ile Thr Lys Ala Ser His Glu His 
        755                 760                 765             


Glu Asp Lys Ser Pro Glu Thr Val Leu Gln Ser Ala Ile Lys Leu Glu 
    770                 775                 780                 


Tyr Ala Arg Leu Val Lys Leu Ala Gln Glu Asp Thr Pro Pro Glu Thr 
785                 790                 795                 800 


Asp Tyr Arg Leu His His Val Val Val Tyr Phe Ile Gln Asn Gln Ala 
                805                 810                 815     


Pro Lys Lys Ile Ile Glu Lys Thr Leu Leu Glu Gln Phe Gly Asp Arg 
            820                 825                 830         


Asn Leu Ser Phe Asp Glu Arg Cys His Asn Ile Met Lys Val Ala Gln 
        835                 840                 845             


Ala Lys Leu Glu Met Ile Lys Pro Glu Glu Val Asn Leu Glu Glu Tyr 
    850                 855                 860                 


Glu Glu Trp His Gln Asp Tyr Arg Lys Phe Arg Glu Thr Thr Met Tyr 
865                 870                 875                 880 


Leu Ile Ile Gly Leu Glu Asn Phe Gln Arg Glu Ser Tyr Ile Asp Ser 
                885                 890                 895     


Leu Leu Phe Leu Ile Cys Ala Tyr Gln Asn Asn Lys Glu Leu Leu Ser 
            900                 905                 910         


Lys Gly Leu Tyr Arg Gly His Asp Glu Glu Leu Ile Ser His Tyr Arg 
        915                 920                 925             


Arg Glu Cys Leu Leu Lys Leu Asn Glu Gln Ala Ala Glu Leu Phe Glu 
    930                 935                 940                 


Ser Gly Glu Asp Arg Glu Val Asn Asn Gly Leu Ile Ile Met Asn Glu 
945                 950                 955                 960 


Phe Ile Val Pro Phe Leu Pro Leu Leu Leu Val Asp Glu Met Glu Glu 
                965                 970                 975     


Lys Asp Ile Leu Ala Val Glu Asp Met Arg Asn Arg Trp Cys Ser Tyr 
            980                 985                 990         


Leu Gly Gln Glu Met Glu Pro His  Leu Gln Glu Lys Leu  Thr Asp Phe 
        995                 1000                 1005             


Leu Pro  Lys Leu Leu Asp Cys  Ser Met Glu Ile Lys  Ser Phe His 
    1010                 1015                 1020             


Glu Pro  Pro Lys Leu Pro Ser  Tyr Ser Thr His Glu  Leu Cys Glu 
    1025                 1030                 1035             


Arg Phe  Ala Arg Ile Met Leu  Ser Leu Ser Arg Thr  Pro Ala Asp 
    1040                 1045                 1050             


Gly Arg  
    1055 


<210> 60
<211> 942
<212> PRT
<213> Homo sapiens

<400> 60
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg Val 
            100                 105                 110         


Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu Gly 
        115                 120                 125             


Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln Glu 
    130                 135                 140                 


Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys Thr 
145                 150                 155                 160 


Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu Glu 
                165                 170                 175     


Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn 
            180                 185                 190         


Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro 
        195                 200                 205             


Leu Thr Gln Phe Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys 
    210                 215                 220                 


Lys Pro Ala Ile Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp 
225                 230                 235                 240 


His Lys Ser Arg Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly 
                245                 250                 255     


Ile Lys Thr Val Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala 
            260                 265                 270         


Gln Glu Phe Leu Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys 
        275                 280                 285             


Glu Gln Val Met Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu 
    290                 295                 300                 


Glu Thr Met Glu Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser 
305                 310                 315                 320 


Cys Glu Ser Cys Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser 
                325                 330                 335     


Arg Cys Phe Ser Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp 
            340                 345                 350         


Asp Glu Asn Asn Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met 
        355                 360                 365             


Cys Asn Lys Ile Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp 
    370                 375                 380                 


Arg Asp Ser Ile Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val 
385                 390                 395                 400 


Lys Val Gln Ile His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His 
                405                 410                 415     


Ser Asn Asp Leu Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val 
            420                 425                 430         


Asn Pro Arg Leu Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro 
        435                 440                 445             


Gly Leu Ala Pro Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg 
    450                 455                 460                 


Lys Lys Gln His Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp 
465                 470                 475                 480 


Gly Thr Ile Ile Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser 
                485                 490                 495     


Val Thr Leu Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys 
            500                 505                 510         


Glu Asp Leu Ala Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val 
        515                 520                 525             


Lys Ala Gly Ser Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala 
    530                 535                 540                 


Phe Phe Met Glu Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser 
545                 550                 555                 560 


Trp Phe Trp Gly Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe 
                565                 570                 575     


Phe Ala Arg Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys 
            580                 585                 590         


Cys Lys Lys Leu Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe 
        595                 600                 605             


Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met 
    610                 615                 620                 


Phe Ser Thr Lys Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu 
625                 630                 635                 640 


Asp Leu Gln Pro Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr 
                645                 650                 655     


Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly 
            660                 665                 670         


His Tyr Ile Ala Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu 
        675                 680                 685             


Phe Asp Asp Gln Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn 
    690                 695                 700                 


Ala Glu Ala Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala Gln 
705                 710                 715                 720 


Lys Glu Arg Arg Arg Ile Ser Asn Leu Leu Asn Ile Met Glu Pro Ser 
                725                 730                 735     


Leu Leu Gln Phe Tyr Ile Ser Arg Gln Trp Leu Asn Lys Phe Lys Thr 
            740                 745                 750         


Phe Ala Glu Pro Gly Pro Ile Ser Asn Asn Asp Phe Leu Cys Ile His 
        755                 760                 765             


Gly Gly Val Pro Pro Arg Lys Ala Gly Tyr Ile Glu Asp Leu Val Leu 
    770                 775                 780                 


Met Leu Pro Gln Asn Ile Trp Asp Asn Leu Tyr Ser Arg Tyr Gly Gly 
785                 790                 795                 800 


Gly Pro Ala Val Asn His Leu Tyr Ile Cys His Thr Cys Gln Ile Glu 
                805                 810                 815     


Ala Glu Lys Ile Glu Lys Arg Arg Lys Thr Glu Leu Glu Ile Phe Ile 
            820                 825                 830         


Arg Leu Asn Arg Ala Phe Gln Lys Glu Asp Ser Pro Ala Thr Phe Tyr 
        835                 840                 845             


Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ser Phe Val Lys Gly 
    850                 855                 860                 


Lys Asp Gly Asp Pro Pro Gly Pro Ile Asp Asn Thr Lys Ile Ala Val 
865                 870                 875                 880 


Thr Lys Cys Gly Asn Val Met Leu Arg Gln Gly Ala Asp Ser Gly Gln 
                885                 890                 895     


Ile Ser Glu Glu Thr Trp Asn Phe Leu Gln Ser Ile Tyr Gly Gly Gly 
            900                 905                 910         


Pro Glu Val Ile Leu Arg Pro Pro Val Val His Val Asp Pro Asp Ile 
        915                 920                 925             


Leu Gln Ala Glu Glu Lys Ile Glu Val Glu Thr Arg Ser Leu 
    930                 935                 940         


<210> 61
<211> 565
<212> PRT
<213> Homo sapiens

<400> 61
Met Pro Gln Ala Ser Glu His Arg Leu Gly Arg Thr Arg Glu Pro Pro 
1               5                   10                  15      


Val Asn Ile Gln Pro Arg Val Gly Ser Lys Leu Pro Phe Ala Pro Arg 
            20                  25                  30          


Ala Arg Ser Lys Glu Arg Arg Asn Pro Ala Ser Gly Pro Asn Pro Met 
        35                  40                  45              


Leu Arg Pro Leu Pro Pro Arg Pro Gly Leu Pro Asp Glu Arg Leu Lys 
    50                  55                  60                  


Lys Leu Glu Leu Gly Arg Gly Arg Thr Ser Gly Pro Arg Pro Arg Gly 
65                  70                  75                  80  


Pro Leu Arg Ala Asp His Gly Val Pro Leu Pro Gly Ser Pro Pro Pro 
                85                  90                  95      


Thr Val Ala Leu Pro Leu Pro Ser Arg Thr Asn Leu Ala Arg Ser Lys 
            100                 105                 110         


Ser Val Ser Ser Gly Asp Leu Arg Pro Met Gly Ile Ala Leu Gly Gly 
        115                 120                 125             


His Arg Gly Thr Gly Glu Leu Gly Ala Ala Leu Ser Arg Leu Ala Leu 
    130                 135                 140                 


Arg Pro Glu Pro Pro Thr Leu Arg Arg Ser Thr Ser Leu Arg Arg Leu 
145                 150                 155                 160 


Gly Gly Phe Pro Gly Pro Pro Thr Leu Phe Ser Ile Arg Thr Glu Pro 
                165                 170                 175     


Pro Ala Ser His Gly Ser Phe His Met Ile Ser Ala Arg Ser Ser Glu 
            180                 185                 190         


Pro Phe Tyr Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly 
        195                 200                 205             


Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn 
    210                 215                 220                 


Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys 
225                 230                 235                 240 


Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln 
                245                 250                 255     


Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro 
            260                 265                 270         


Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln 
        275                 280                 285             


Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu 
    290                 295                 300                 


Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg 
305                 310                 315                 320 


Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro 
                325                 330                 335     


Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp 
            340                 345                 350         


Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser 
        355                 360                 365             


Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys 
    370                 375                 380                 


Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu 
385                 390                 395                 400 


Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu 
                405                 410                 415     


Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu 
            420                 425                 430         


Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys 
        435                 440                 445             


Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn 
    450                 455                 460                 


Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val 
465                 470                 475                 480 


Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys 
                485                 490                 495     


Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly 
            500                 505                 510         


Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly 
        515                 520                 525             


Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln 
    530                 535                 540                 


Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu 
545                 550                 555                 560 


Pro Pro Arg Cys Leu 
                565 


<210> 62
<211> 530
<212> PRT
<213> Homo sapiens

<400> 62
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly Tyr Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Glu Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Met Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Met Asn Ser Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 63
<211> 530
<212> PRT
<213> Homo sapiens

<400> 63
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 64
<211> 370
<212> PRT
<213> Homo sapiens

<400> 64
Met Glu Ile Leu Met Thr Val Ser Lys Phe Ala Ser Ile Cys Thr Met 
1               5                   10                  15      


Gly Ala Asn Ala Ser Ala Leu Glu Lys Glu Ile Gly Pro Glu Gln Phe 
            20                  25                  30          


Pro Val Asn Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys 
        35                  40                  45              


Tyr Cys Asn Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg 
    50                  55                  60                  


Glu Lys Val Leu Ala Tyr Lys Ser Gln Pro Arg Lys Lys Glu Ser Leu 
65                  70                  75                  80  


Leu Thr Cys Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys 
                85                  90                  95      


Lys Val Gly Val Ile Pro Pro Lys Lys Phe Ile Thr Arg Leu Arg Lys 
            100                 105                 110         


Glu Asn Glu Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe 
        115                 120                 125             


Leu Asn Tyr Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Arg 
    130                 135                 140                 


Lys Gln Glu Lys Gln Asn Gly Arg Leu Pro Asn Gly Asn Ile Asp Asn 
145                 150                 155                 160 


Glu Asn Asn Asn Ser Thr Pro Asp Pro Thr Trp Val His Glu Ile Phe 
                165                 170                 175     


Gln Gly Thr Leu Thr Asn Glu Thr Arg Cys Leu Thr Cys Glu Thr Ile 
            180                 185                 190         


Ser Ser Lys Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln 
        195                 200                 205             


Asn Thr Ser Ile Thr His Cys Leu Arg Gly Phe Ser Asn Thr Glu Thr 
    210                 215                 220                 


Leu Cys Ser Glu Tyr Lys Tyr Tyr Cys Glu Glu Cys Arg Ser Lys Gln 
225                 230                 235                 240 


Glu Ala His Lys Arg Met Lys Val Lys Lys Leu Pro Met Ile Leu Ala 
                245                 250                 255     


Leu His Leu Lys Arg Phe Lys Tyr Met Asp Gln Leu His Arg Tyr Thr 
            260                 265                 270         


Lys Leu Ser Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn 
        275                 280                 285             


Thr Ser Gly Asp Ala Thr Asn Pro Asp Arg Met Tyr Asp Leu Val Ala 
    290                 295                 300                 


Val Val Val His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Ala 
305                 310                 315                 320 


Ile Val Lys Ser His Asp Phe Trp Leu Leu Phe Asp Asp Asp Ile Val 
                325                 330                 335     


Glu Lys Ile Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser 
            340                 345                 350         


Asp Ile Ser Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser 
        355                 360                 365             


Arg Asp 
    370 


<210> 65
<211> 530
<212> PRT
<213> Homo sapiens

<400> 65
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Asn Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr Leu Leu Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Lys Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 66
<211> 914
<212> PRT
<213> Homo sapiens

<400> 66
Met Gly Asp Ser Arg Asp Leu Cys Pro His Leu Asp Ser Ile Gly Glu 
1               5                   10                  15      


Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Gly Thr Cys Gln Ser 
            20                  25                  30          


Cys Gly Val Thr Gly Pro Asn Leu Trp Ala Cys Leu Gln Val Ala Cys 
        35                  40                  45              


Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His 
    50                  55                  60                  


Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg 
65                  70                  75                  80  


Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu 
                85                  90                  95      


Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser 
            100                 105                 110         


Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp 
        115                 120                 125             


Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu 
    130                 135                 140                 


Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu 
145                 150                 155                 160 


Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe Phe Leu Glu Cys 
                165                 170                 175     


Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr 
            180                 185                 190         


Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val 
        195                 200                 205             


Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe 
    210                 215                 220                 


Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met 
225                 230                 235                 240 


Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala 
                245                 250                 255     


Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg 
            260                 265                 270         


Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser 
        275                 280                 285             


Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser 
    290                 295                 300                 


Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala 
305                 310                 315                 320 


Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln 
                325                 330                 335     


Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr 
            340                 345                 350         


Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser 
        355                 360                 365             


Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala 
    370                 375                 380                 


His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu 
385                 390                 395                 400 


Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg 
                405                 410                 415     


Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly 
            420                 425                 430         


Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile 
        435                 440                 445             


Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg 
    450                 455                 460                 


Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro 
465                 470                 475                 480 


Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val 
                485                 490                 495     


Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp 
            500                 505                 510         


Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr 
        515                 520                 525             


Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala 
    530                 535                 540                 


Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys 
545                 550                 555                 560 


Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu 
                565                 570                 575     


Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu 
            580                 585                 590         


Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu 
        595                 600                 605             


Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile 
    610                 615                 620                 


Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly 
625                 630                 635                 640 


Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp 
                645                 650                 655     


Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val 
            660                 665                 670         


Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu 
        675                 680                 685             


Ala Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu 
    690                 695                 700                 


Pro Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe 
705                 710                 715                 720 


Asn Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys 
                725                 730                 735     


Ser His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu 
            740                 745                 750         


Val Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe 
        755                 760                 765             


Gly Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln 
    770                 775                 780                 


Val Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr 
785                 790                 795                 800 


Phe Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val 
                805                 810                 815     


Ile Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val 
            820                 825                 830         


Lys Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile 
        835                 840                 845             


Ala Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp 
    850                 855                 860                 


Tyr Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr 
865                 870                 875                 880 


Gly Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu 
                885                 890                 895     


Gly Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg 
            900                 905                 910         


Ala Val 
        


<210> 67
<211> 366
<212> PRT
<213> Homo sapiens

<400> 67
Met Thr Val Arg Asn Ile Ala Ser Ile Cys Asn Met Gly Thr Asn Ala 
1               5                   10                  15      


Ser Ala Leu Glu Lys Asp Ile Gly Pro Glu Gln Phe Pro Ile Asn Glu 
            20                  25                  30          


His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn Ser 
        35                  40                  45              


Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Asn Val Leu 
    50                  55                  60                  


Ala Tyr Lys Ala Gln Gln Lys Lys Lys Glu Asn Leu Leu Thr Cys Leu 
65                  70                  75                  80  


Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly Val 
                85                  90                  95      


Ile Pro Pro Lys Lys Phe Ile Ser Arg Leu Arg Lys Glu Asn Asp Leu 
            100                 105                 110         


Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr Leu 
        115                 120                 125             


Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Lys Lys Gln Glu Lys 
    130                 135                 140                 


Gln Asn Gly Lys Leu Lys Asn Gly Asn Met Asn Glu Pro Ala Glu Asn 
145                 150                 155                 160 


Asn Lys Pro Glu Leu Thr Trp Val His Glu Ile Phe Gln Gly Thr Leu 
                165                 170                 175     


Thr Asn Glu Thr Arg Cys Leu Asn Cys Glu Thr Val Ser Ser Lys Asp 
            180                 185                 190         


Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser Ile 
        195                 200                 205             


Thr His Cys Leu Arg Asp Phe Ser Asn Thr Glu Thr Leu Cys Ser Glu 
    210                 215                 220                 


Gln Lys Tyr Tyr Cys Glu Thr Cys Cys Ser Lys Gln Glu Ala Gln Lys 
225                 230                 235                 240 


Arg Met Arg Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu Lys 
                245                 250                 255     


Arg Phe Lys Tyr Met Glu Gln Leu His Arg Tyr Thr Lys Leu Ser Tyr 
            260                 265                 270         


Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Ser Asp 
        275                 280                 285             


Ala Val Asn Leu Asp Arg Met Tyr Asp Leu Val Ala Val Val Val His 
    290                 295                 300                 


Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Thr Ile Val Lys Ser 
305                 310                 315                 320 


His Gly Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile Asp 
                325                 330                 335     


Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser Lys 
            340                 345                 350         


Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg Glu 
        355                 360                 365     


<210> 68
<211> 956
<212> PRT
<213> Homo sapiens

<400> 68
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Ala Leu Ser Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala 
305                 310                 315                 320 


Phe Met Ser Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys 
                325                 330                 335     


Pro Lys Ala Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser 
            340                 345                 350         


Glu Leu Phe Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln 
        355                 360                 365             


Ser Lys Ser Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro 
    370                 375                 380                 


Ala Lys Ser Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro 
385                 390                 395                 400 


Pro Leu Gln Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe 
                405                 410                 415     


His Ser Leu Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser 
            420                 425                 430         


Ile Gly His Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu 
        435                 440                 445             


Leu Asn Thr Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro 
    450                 455                 460                 


Gly Asn Ser His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu 
465                 470                 475                 480 


Asn Pro Pro Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly 
                485                 490                 495     


Leu Asn Glu Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly 
            500                 505                 510         


Cys Thr Asp Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu 
        515                 520                 525             


Lys Lys Ala Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg 
    530                 535                 540                 


Phe Ala Ser Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser 
545                 550                 555                 560 


Leu Ala Phe Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro 
                565                 570                 575     


Pro Lys Met Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys 
            580                 585                 590         


Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe 
        595                 600                 605             


Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro 
    610                 615                 620                 


Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu 
625                 630                 635                 640 


Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala 
                645                 650                 655     


Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala 
            660                 665                 670         


Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile 
        675                 680                 685             


Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser 
    690                 695                 700                 


Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu 
705                 710                 715                 720 


Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp 
                725                 730                 735     


Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu 
            740                 745                 750         


Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys 
        755                 760                 765             


Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr 
    770                 775                 780                 


Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg 
785                 790                 795                 800 


Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe 
                805                 810                 815     


Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn 
            820                 825                 830         


His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp 
        835                 840                 845             


Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val 
    850                 855                 860                 


Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys 
865                 870                 875                 880 


Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly 
                885                 890                 895     


Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val 
            900                 905                 910         


Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser 
        915                 920                 925             


Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met 
    930                 935                 940                 


Cys Met Tyr Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950                 955     


<210> 69
<211> 823
<212> PRT
<213> Homo sapiens

<400> 69
Met Gly Lys Lys Arg Thr Lys Gly Lys Thr Val Pro Ile Asp Asp Ser 
1               5                   10                  15      


Ser Glu Thr Leu Glu Pro Val Cys Arg His Ile Arg Lys Gly Leu Glu 
            20                  25                  30          


Gln Gly Asn Leu Lys Lys Ala Leu Val Asn Val Glu Trp Asn Ile Cys 
        35                  40                  45              


Gln Asp Cys Lys Thr Asp Asn Lys Val Lys Asp Lys Ala Glu Glu Glu 
    50                  55                  60                  


Thr Glu Glu Lys Pro Ser Val Trp Leu Cys Leu Lys Cys Gly His Gln 
65                  70                  75                  80  


Gly Cys Gly Arg Asn Ser Gln Glu Gln His Ala Leu Lys His Tyr Leu 
                85                  90                  95      


Thr Pro Arg Ser Glu Pro His Cys Leu Val Leu Ser Leu Asp Asn Trp 
            100                 105                 110         


Ser Val Trp Cys Tyr Val Cys Asp Asn Glu Val Gln Tyr Cys Ser Ser 
        115                 120                 125             


Asn Gln Leu Gly Gln Val Val Asp Tyr Val Arg Lys Gln Ala Ser Ile 
    130                 135                 140                 


Thr Thr Pro Lys Pro Ala Glu Lys Asp Asn Gly Asn Ile Glu Leu Glu 
145                 150                 155                 160 


Asn Lys Lys Leu Glu Lys Glu Ser Lys Asn Glu Gln Glu Arg Glu Lys 
                165                 170                 175     


Lys Glu Asn Met Ala Lys Glu Asn Pro Pro Met Asn Ser Pro Cys Gln 
            180                 185                 190         


Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
        195                 200                 205             


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
    210                 215                 220                 


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
225                 230                 235                 240 


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
                245                 250                 255     


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
            260                 265                 270         


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
        275                 280                 285             


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
    290                 295                 300                 


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
305                 310                 315                 320 


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
                325                 330                 335     


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
            340                 345                 350         


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
        355                 360                 365             


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
    370                 375                 380                 


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
385                 390                 395                 400 


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
                405                 410                 415     


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
            420                 425                 430         


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
        435                 440                 445             


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
    450                 455                 460                 


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
465                 470                 475                 480 


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
                485                 490                 495     


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
            500                 505                 510         


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
        515                 520                 525             


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
    530                 535                 540                 


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
545                 550                 555                 560 


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
                565                 570                 575     


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
            580                 585                 590         


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
        595                 600                 605             


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
    610                 615                 620                 


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
625                 630                 635                 640 


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
                645                 650                 655     


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
            660                 665                 670         


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
        675                 680                 685             


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
    690                 695                 700                 


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
705                 710                 715                 720 


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
                725                 730                 735     


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
            740                 745                 750         


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
        755                 760                 765             


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
    770                 775                 780                 


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
785                 790                 795                 800 


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
                805                 810                 815     


Leu Phe Tyr Glu Arg Ile Leu 
            820             


<210> 70
<211> 1137
<212> PRT
<213> Homo sapiens

<400> 70
Met Lys Cys Val Phe Val Thr Val Gly Thr Thr Ser Phe Asp Asp Leu 
1               5                   10                  15      


Ile Ala Cys Val Ser Ala Pro Asp Ser Leu Gln Lys Ile Glu Ser Leu 
            20                  25                  30          


Gly Tyr Asn Arg Leu Ile Leu Gln Ile Gly Arg Gly Thr Val Val Pro 
        35                  40                  45              


Glu Pro Phe Ser Thr Glu Ser Phe Thr Leu Asp Val Tyr Arg Tyr Lys 
    50                  55                  60                  


Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu Val Ile Ser His 
65                  70                  75                  80  


Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys Gly Lys Pro Leu 
                85                  90                  95      


Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His Gln Leu Glu Leu 
            100                 105                 110         


Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr Cys Thr Cys Arg 
        115                 120                 125             


Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala Ser Ala Pro Gly 
    130                 135                 140                 


Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala Phe Ser Gly Leu 
145                 150                 155                 160 


Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln Ala Leu Val Thr 
                165                 170                 175     


Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser Cys His Ala Phe 
            180                 185                 190         


Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met His Lys Gly Trp 
        195                 200                 205             


Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala Ser Met Asp Glu 
    210                 215                 220                 


Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr Ala Lys Asp Ala 
225                 230                 235                 240 


Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe Cys Ser Gln Val 
                245                 250                 255     


His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr Met Arg Glu Asn 
            260                 265                 270         


Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe Glu Lys Tyr Leu 
        275                 280                 285             


Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln Leu Glu Ile Arg 
    290                 295                 300                 


Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu Tyr Arg Phe Pro 
305                 310                 315                 320 


Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr Glu Asp Lys Ile 
                325                 330                 335     


Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser Val Tyr Ser Lys 
            340                 345                 350         


Gln Phe Gln Ser Ser Ala Ala Val Cys Gln Ala Val Leu Tyr Glu Ile 
        355                 360                 365             


Leu Tyr Lys Asp Val Phe Val Val Asp Glu Glu Glu Leu Lys Thr Ala 
    370                 375                 380                 


Ile Lys Leu Phe Arg Ser Gly Ser Lys Lys Asn Arg Asn Asn Ala Val 
385                 390                 395                 400 


Thr Gly Ser Glu Asp Ala His Thr Asp Tyr Lys Ser Ser Asn Gln Asn 
                405                 410                 415     


Arg Met Glu Glu Trp Gly Ala Cys Tyr Asn Ala Glu Asn Ile Pro Glu 
            420                 425                 430         


Gly Tyr Asn Lys Gly Thr Glu Glu Thr Lys Ser Pro Glu Asn Pro Ser 
        435                 440                 445             


Lys Met Pro Phe Pro Tyr Lys Val Leu Lys Ala Leu Asp Pro Glu Ile 
    450                 455                 460                 


Tyr Arg Asn Val Glu Phe Asp Val Trp Leu Asp Ser Arg Lys Glu Leu 
465                 470                 475                 480 


Gln Lys Ser Asp Tyr Met Glu Tyr Ala Gly Arg Gln Tyr Tyr Leu Gly 
                485                 490                 495     


Asp Lys Cys Gln Val Cys Leu Glu Ser Glu Gly Arg Tyr Tyr Asn Ala 
            500                 505                 510         


His Ile Gln Glu Val Gly Asn Glu Asn Asn Ser Val Thr Val Phe Ile 
        515                 520                 525             


Glu Glu Leu Ala Glu Lys His Val Val Pro Leu Ala Asn Leu Lys Pro 
    530                 535                 540                 


Val Thr Gln Val Met Ser Val Pro Ala Trp Asn Ala Met Pro Ser Arg 
545                 550                 555                 560 


Lys Gly Arg Gly Tyr Gln Lys Met Pro Gly Gly Tyr Val Pro Glu Ile 
                565                 570                 575     


Val Ile Ser Glu Met Asp Ile Lys Gln Gln Lys Lys Met Phe Lys Lys 
            580                 585                 590         


Ile Arg Gly Lys Glu Val Tyr Met Thr Met Ala Tyr Gly Lys Gly Asp 
        595                 600                 605             


Pro Leu Leu Pro Pro Arg Leu Gln His Ser Met His Tyr Gly His Asp 
    610                 615                 620                 


Pro Pro Met His Tyr Ser Gln Thr Ala Gly Asn Val Met Ser Asn Glu 
625                 630                 635                 640 


His Phe His Pro Gln His Pro Ser Pro Arg Gln Gly Arg Gly Tyr Gly 
                645                 650                 655     


Met Pro Arg Asn Ser Ser Arg Phe Ile Asn Arg His Asn Met Pro Gly 
            660                 665                 670         


Pro Lys Val Asp Phe Tyr Pro Gly Pro Gly Lys Arg Cys Cys Gln Ser 
        675                 680                 685             


Tyr Asp Asn Phe Ser Tyr Arg Ser Arg Ser Phe Arg Arg Ser His Arg 
    690                 695                 700                 


Gln Met Ser Cys Val Asn Lys Glu Ser Gln Tyr Gly Phe Thr Pro Gly 
705                 710                 715                 720 


Asn Gly Gln Met Pro Arg Gly Leu Glu Glu Thr Ile Thr Phe Tyr Glu 
                725                 730                 735     


Val Glu Glu Gly Asp Glu Thr Ala Tyr Pro Thr Leu Pro Asn His Gly 
            740                 745                 750         


Gly Pro Ser Thr Met Val Pro Ala Thr Ser Gly Tyr Cys Val Gly Arg 
        755                 760                 765             


Arg Gly His Ser Ser Gly Lys Gln Thr Leu Asn Leu Glu Glu Gly Asn 
    770                 775                 780                 


Gly Gln Ser Glu Asn Gly Arg Tyr His Glu Glu Tyr Leu Tyr Arg Ala 
785                 790                 795                 800 


Glu Pro Asp Tyr Glu Thr Ser Gly Val Tyr Ser Thr Thr Ala Ser Thr 
                805                 810                 815     


Ala Asn Leu Ser Leu Gln Asp Arg Lys Ser Cys Ser Met Ser Pro Gln 
            820                 825                 830         


Asp Thr Val Thr Ser Tyr Asn Tyr Pro Gln Lys Met Met Gly Asn Ile 
        835                 840                 845             


Ala Ala Val Ala Ala Ser Cys Ala Asn Asn Val Pro Ala Pro Val Leu 
    850                 855                 860                 


Ser Asn Gly Ala Ala Ala Asn Gln Ala Ile Ser Thr Thr Ser Val Ser 
865                 870                 875                 880 


Ser Gln Asn Ala Ile Gln Pro Leu Phe Val Ser Pro Pro Thr His Gly 
                885                 890                 895     


Arg Pro Val Ile Ala Ser Pro Ser Tyr Pro Cys His Ser Ala Ile Pro 
            900                 905                 910         


His Ala Gly Ala Ser Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    930                 935                 940                 


Pro Ala Leu Asp Val Gly Glu Thr Ser Asn Leu Gln Pro Pro Pro Pro 
945                 950                 955                 960 


Leu Pro Pro Pro Pro Tyr Ser Cys Asp Pro Ser Gly Ser Asp Leu Pro 
                965                 970                 975     


Gln Asp Thr Lys Val Leu Gln Tyr Tyr Phe Asn Leu Gly Leu Gln Cys 
            980                 985                 990         


Tyr Tyr His Ser Tyr Trp His Ser  Met Val Tyr Val Pro  Gln Met Gln 
        995                 1000                 1005             


Gln Gln  Leu His Val Glu Asn  Tyr Pro Val Tyr Thr  Glu Pro Pro 
    1010                 1015                 1020             


Leu Val  Asp Gln Thr Val Pro  Gln Cys Tyr Ser Glu  Val Arg Arg 
    1025                 1030                 1035             


Glu Asp  Gly Ile Gln Ala Glu  Ala Ser Ala Asn Asp  Thr Phe Pro 
    1040                 1045                 1050             


Asn Ala  Asp Ser Ser Ser Val  Pro His Gly Ala Val  Tyr Tyr Pro 
    1055                 1060                 1065             


Val Met  Ser Asp Pro Tyr Gly  Gln Pro Pro Leu Pro  Gly Phe Asp 
    1070                 1075                 1080             


Ser Cys  Leu Pro Val Val Pro  Asp Tyr Ser Cys Val  Pro Pro Trp 
    1085                 1090                 1095             


His Pro  Val Gly Thr Ala Tyr  Gly Gly Ser Ser Gln  Ile His Gly 
    1100                 1105                 1110             


Ala Ile  Asn Pro Gly Pro Ile  Gly Cys Ile Ala Pro  Ser Pro Pro 
    1115                 1120                 1125             


Ala Ser  His Tyr Val Pro Gln  Gly Met 
    1130                 1135         


<210> 71
<211> 348
<212> PRT
<213> Homo sapiens

<400> 71
Met Phe Gly Pro Ala Lys Gly Arg His Phe Gly Val His Pro Ala Pro 
1               5                   10                  15      


Gly Phe Pro Gly Gly Val Ser Gln Gln Ala Ala Gly Thr Lys Ala Gly 
            20                  25                  30          


Pro Ala Gly Ala Trp Pro Val Gly Ser Arg Thr Asp Thr Met Trp Arg 
        35                  40                  45              


Leu Arg Cys Lys Ala Lys Asp Gly Thr His Val Leu Gln Gly Leu Ser 
    50                  55                  60                  


Ser Arg Thr Arg Val Arg Glu Leu Gln Gly Gln Ile Ala Ala Ile Thr 
65                  70                  75                  80  


Gly Ile Ala Pro Gly Gly Gln Arg Ile Leu Val Gly Tyr Pro Pro Glu 
                85                  90                  95      


Cys Leu Asp Leu Ser Asn Gly Asp Thr Ile Leu Glu Asp Leu Pro Ile 
            100                 105                 110         


Gln Ser Gly Asp Met Leu Ile Ile Glu Glu Asp Gln Thr Arg Pro Arg 
        115                 120                 125             


Ser Ser Pro Ala Phe Thr Lys Arg Gly Ala Ser Ser Tyr Val Arg Glu 
    130                 135                 140                 


Thr Leu Pro Val Leu Thr Arg Thr Val Val Pro Ala Asp Asn Ser Cys 
145                 150                 155                 160 


Leu Phe Thr Ser Val Tyr Tyr Val Val Glu Gly Gly Val Leu Asn Pro 
                165                 170                 175     


Ala Cys Ala Pro Glu Met Arg Arg Leu Ile Ala Gln Ile Val Ala Ser 
            180                 185                 190         


Asp Pro Asp Phe Tyr Ser Glu Ala Ile Leu Gly Lys Thr Asn Gln Glu 
        195                 200                 205             


Tyr Cys Asp Trp Ile Lys Arg Asp Asp Thr Trp Gly Gly Ala Ile Glu 
    210                 215                 220                 


Ile Ser Ile Leu Ser Lys Phe Tyr Gln Cys Glu Ile Cys Val Val Asp 
225                 230                 235                 240 


Thr Gln Thr Val Arg Ile Asp Arg Phe Gly Glu Asp Ala Gly Tyr Thr 
                245                 250                 255     


Lys Arg Val Leu Leu Ile Tyr Asp Gly Ile His Tyr Asp Pro Leu Gln 
            260                 265                 270         


Arg Asn Phe Pro Asp Pro Asp Thr Pro Pro Leu Thr Ile Phe Ser Ser 
        275                 280                 285             


Asn Asp Asp Ile Val Leu Val Gln Ala Leu Glu Leu Ala Asp Glu Ala 
    290                 295                 300                 


Arg Arg Arg Arg Gln Phe Thr Asp Val Asn Arg Phe Thr Leu Arg Cys 
305                 310                 315                 320 


Met Val Cys Gln Lys Gly Leu Thr Gly Gln Ala Glu Ala Arg Glu His 
                325                 330                 335     


Ala Lys Glu Thr Gly His Thr Asn Phe Gly Glu Val 
            340                 345             


<210> 72
<211> 481
<212> PRT
<213> Homo sapiens

<400> 72
Met Gln Leu Tyr Ser Ser Val Cys Thr His Tyr Pro Ala Gly Ala Pro 
1               5                   10                  15      


Gly Pro Thr Ala Ala Ala Pro Ala Pro Pro Ala Ala Ala Thr Pro Phe 
            20                  25                  30          


Lys Val Ser Leu Gln Pro Pro Gly Ala Ala Gly Ala Ala Pro Glu Pro 
        35                  40                  45              


Glu Thr Gly Glu Cys Gln Pro Ala Ala Ala Ala Glu His Arg Glu Ala 
    50                  55                  60                  


Ala Ala Val Pro Ala Ala Lys Met Pro Ala Phe Ser Ser Cys Phe Glu 
65                  70                  75                  80  


Val Val Ser Gly Ala Ala Ala Pro Ala Ser Ala Ala Ala Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Cys Lys Pro Pro Leu Pro Pro His Tyr Thr Ser Thr Ala 
            100                 105                 110         


Gln Ile Thr Val Arg Ala Leu Gly Ala Asp Arg Leu Leu Leu His Gly 
        115                 120                 125             


Pro Asp Pro Val Pro Gly Ala Ala Gly Ser Ala Ala Ala Pro Arg Gly 
    130                 135                 140                 


Arg Cys Leu Leu Leu Ala Pro Ala Pro Ala Ala Pro Val Pro Pro Arg 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Trp Leu Leu Glu Glu Leu Leu Arg Pro Asp Cys 
                165                 170                 175     


Pro Glu Pro Ala Gly Leu Asp Ala Thr Arg Glu Gly Pro Asp Arg Asn 
            180                 185                 190         


Phe Arg Leu Ser Glu His Arg Gln Ala Leu Ala Ala Ala Lys His Arg 
        195                 200                 205             


Gly Pro Ala Ala Thr Pro Gly Ser Pro Asp Pro Gly Pro Gly Pro Trp 
    210                 215                 220                 


Gly Glu Glu His Leu Ala Glu Arg Gly Pro Arg Gly Trp Glu Arg Gly 
225                 230                 235                 240 


Gly Asp Arg Cys Asp Ala Pro Gly Gly Asp Ala Ala Arg Arg Pro Asp 
                245                 250                 255     


Pro Glu Ala Glu Ala Pro Pro Ala Gly Ser Ile Glu Ala Ala Pro Ser 
            260                 265                 270         


Ser Ala Ala Glu Pro Val Ile Val Ser Arg Ser Asp Pro Arg Asp Glu 
        275                 280                 285             


Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu 
    290                 295                 300                 


Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly Asn Cys 
305                 310                 315                 320 


Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser Leu His 
                325                 330                 335     


Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala Asp His Leu Asp 
            340                 345                 350         


His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile Ile Ala 
        355                 360                 365             


Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met 
    370                 375                 380                 


Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly Arg Leu 
385                 390                 395                 400 


Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro Glu Asp 
                405                 410                 415     


Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly His Tyr 
            420                 425                 430         


Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp 
        435                 440                 445             


Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys 
    450                 455                 460                 


Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys 
465                 470                 475                 480 


Ser 
    


<210> 73
<211> 293
<212> PRT
<213> Homo sapiens

<400> 73
Met Glu Ala Val Leu Thr Glu Glu Leu Asp Glu Glu Glu Gln Leu Leu 
1               5                   10                  15      


Arg Arg His Arg Lys Glu Lys Lys Glu Leu Gln Ala Lys Ile Gln Gly 
            20                  25                  30          


Met Lys Asn Ala Val Pro Lys Asn Asp Lys Lys Arg Arg Lys Gln Leu 
        35                  40                  45              


Thr Glu Asp Val Ala Lys Leu Glu Lys Glu Met Glu Gln Lys His Arg 
    50                  55                  60                  


Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu Asn Lys Ile Asp 
65                  70                  75                  80  


Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu Asn Gln Pro Pro 
                85                  90                  95      


Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys Ala Ala Leu Glu 
            100                 105                 110         


Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile Glu Asn Leu Thr 
        115                 120                 125             


Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln Ile Leu Ala Ala 
    130                 135                 140                 


Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly His Cys Met Tyr 
145                 150                 155                 160 


Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys Ala Leu Thr Val 
                165                 170                 175     


Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln Ser His Val Glu 
            180                 185                 190         


Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly Asp Met Tyr Thr 
        195                 200                 205             


Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val Asn Thr Ala Ala 
    210                 215                 220                 


Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His Ile Leu Gln Thr 
225                 230                 235                 240 


Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile Ile Val Gly Glu 
                245                 250                 255     


Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met Arg His Ala Tyr 
            260                 265                 270         


Gly Leu Gly Glu His Tyr Asn Ser Val Thr Arg Leu Val Asn Ile Val 
        275                 280                 285             


Thr Glu Asn Cys Ser 
    290             


<210> 74
<211> 288
<212> PRT
<213> Homo sapiens

<400> 74
Met Asp Asp Pro Lys Ser Glu Gln Gln Arg Ile Leu Arg Arg His Gln 
1               5                   10                  15      


Arg Glu Arg Gln Glu Leu Gln Ala Gln Ile Arg Ser Leu Lys Asn Ser 
            20                  25                  30          


Val Pro Lys Thr Asp Lys Thr Lys Arg Lys Gln Leu Leu Gln Asp Val 
        35                  40                  45              


Ala Arg Met Glu Ala Glu Met Ala Gln Lys His Arg Gln Glu Leu Glu 
    50                  55                  60                  


Lys Phe Gln Asp Asp Ser Ser Ile Glu Ser Val Val Glu Asp Leu Ala 
65                  70                  75                  80  


Lys Met Asn Leu Glu Asn Arg Pro Pro Arg Ser Ser Lys Ala His Arg 
                85                  90                  95      


Lys Arg Glu Arg Met Glu Ser Glu Glu Arg Glu Arg Gln Glu Ser Ile 
            100                 105                 110         


Phe Gln Ala Glu Met Ser Glu His Leu Ala Gly Phe Lys Arg Glu Glu 
        115                 120                 125             


Glu Glu Lys Leu Ala Ala Ile Leu Gly Ala Arg Gly Leu Glu Met Lys 
    130                 135                 140                 


Ala Ile Pro Ala Asp Gly His Cys Met Tyr Arg Ala Ile Gln Asp Gln 
145                 150                 155                 160 


Leu Val Phe Ser Val Ser Val Glu Met Leu Arg Cys Arg Thr Ala Ser 
                165                 170                 175     


Tyr Met Lys Lys His Val Asp Glu Phe Leu Pro Phe Phe Ser Asn Pro 
            180                 185                 190         


Glu Thr Ser Asp Ser Phe Gly Tyr Asp Asp Phe Met Ile Tyr Cys Asp 
        195                 200                 205             


Asn Ile Val Arg Thr Thr Ala Trp Gly Gly Gln Leu Glu Leu Arg Ala 
    210                 215                 220                 


Leu Ser His Val Leu Lys Thr Pro Ile Glu Val Ile Gln Ala Asp Ser 
225                 230                 235                 240 


Pro Thr Leu Ile Ile Gly Glu Glu Tyr Val Lys Lys Pro Ile Ile Leu 
                245                 250                 255     


Val Tyr Leu Arg Tyr Ala Tyr Ser Leu Gly Glu His Tyr Asn Ser Val 
            260                 265                 270         


Thr Pro Leu Glu Ala Gly Ala Ala Gly Gly Val Leu Pro Arg Leu Leu 
        275                 280                 285             


<210> 75
<211> 271
<212> PRT
<213> Homo sapiens

<400> 75
Met Ala Ala Glu Glu Pro Gln Gln Gln Lys Gln Glu Pro Leu Gly Ser 
1               5                   10                  15      


Asp Ser Glu Gly Val Asn Cys Leu Ala Tyr Asp Glu Ala Ile Met Ala 
            20                  25                  30          


Gln Gln Asp Arg Ile Gln Gln Glu Ile Ala Val Gln Asn Pro Leu Val 
        35                  40                  45              


Ser Glu Arg Leu Glu Leu Ser Val Leu Tyr Lys Glu Tyr Ala Glu Asp 
    50                  55                  60                  


Asp Asn Ile Tyr Gln Gln Lys Ile Lys Asp Leu His Lys Lys Tyr Ser 
65                  70                  75                  80  


Tyr Ile Arg Lys Thr Arg Pro Asp Gly Asn Cys Phe Tyr Arg Ala Phe 
                85                  90                  95      


Gly Phe Ser His Leu Glu Ala Leu Leu Asp Asp Ser Lys Glu Leu Gln 
            100                 105                 110         


Arg Phe Lys Ala Val Ser Ala Lys Ser Lys Glu Asp Leu Val Ser Gln 
        115                 120                 125             


Gly Phe Thr Glu Phe Thr Ile Glu Asp Phe His Asn Thr Phe Met Asp 
    130                 135                 140                 


Leu Ile Glu Gln Val Glu Lys Gln Thr Ser Val Ala Asp Leu Leu Ala 
145                 150                 155                 160 


Ser Phe Asn Asp Gln Ser Thr Ser Asp Tyr Leu Val Val Tyr Leu Arg 
                165                 170                 175     


Leu Leu Thr Ser Gly Tyr Leu Gln Arg Glu Ser Lys Phe Phe Glu His 
            180                 185                 190         


Phe Ile Glu Gly Gly Arg Thr Val Lys Glu Phe Cys Gln Gln Glu Val 
        195                 200                 205             


Glu Pro Met Cys Lys Glu Ser Asp His Ile His Ile Ile Ala Leu Ala 
    210                 215                 220                 


Gln Ala Leu Ser Val Ser Ile Gln Val Glu Tyr Met Asp Arg Gly Glu 
225                 230                 235                 240 


Gly Gly Thr Thr Asn Pro His Ile Phe Pro Glu Gly Ser Glu Pro Lys 
                245                 250                 255     


Val Tyr Leu Leu Tyr Arg Pro Gly His Tyr Asp Ile Leu Tyr Lys 
            260                 265                 270     


<210> 76
<211> 926
<212> PRT
<213> Homo sapiens

<400> 76
Met Val Ser Ser Val Leu Pro Asn Pro Thr Ser Ala Glu Cys Trp Ala 
1               5                   10                  15      


Ala Leu Leu His Asp Pro Met Thr Leu Asp Met Asp Ala Val Leu Ser 
            20                  25                  30          


Asp Phe Val Arg Ser Thr Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu 
        35                  40                  45              


Leu Glu Gly Lys Asn Trp Asp Leu Thr Ala Ala Leu Ser Asp Tyr Glu 
    50                  55                  60                  


Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His Val Phe Asn Glu 
65                  70                  75                  80  


Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln Pro Gly His Lys 
                85                  90                  95      


Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile Ala Gln Glu Lys 
            100                 105                 110         


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala Ile Val Ser Leu 
        115                 120                 125             


Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu Gln Phe Pro Leu 
    130                 135                 140                 


Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu Ser Val Tyr Ser 
145                 150                 155                 160 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ala Thr 
                165                 170                 175     


Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Ser Thr Val 
            180                 185                 190         


Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
        195                 200                 205             


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
    210                 215                 220                 


Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met Met Arg Thr Gly 
225                 230                 235                 240 


Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
                245                 250                 255     


Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr Glu Leu Leu Lys 
            260                 265                 270         


Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys Asn Gly Gly Thr 
        275                 280                 285             


Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr Glu Ser Leu Glu 
    290                 295                 300                 


Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Val 
305                 310                 315                 320 


Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala 
                325                 330                 335     


Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Pro Asn 
            340                 345                 350         


Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe 
        355                 360                 365             


Ser Ala Leu Val Ser Met Glu Gln Arg Asp Gln Gln Arg Glu Gln Ala 
    370                 375                 380                 


Val Ile Pro Leu Thr Asp Ser Glu His Lys Leu Leu Pro Leu His Phe 
385                 390                 395                 400 


Ala Val Asp Pro Gly Lys Asp Trp Glu Trp Gly Lys Asp Asp Asn Asp 
                405                 410                 415     


Asn Ala Arg Leu Ala His Leu Ile Leu Ser Leu Glu Ala Lys Leu Asn 
            420                 425                 430         


Leu Leu His Ser Tyr Met Asn Val Thr Trp Ile Arg Ile Pro Ser Glu 
        435                 440                 445             


Thr Arg Ala Pro Leu Ala Gln Pro Glu Ser Pro Thr Ala Ser Ala Gly 
    450                 455                 460                 


Glu Asp Val Gln Ser Leu Ala Asp Ser Leu Asp Ser Asp Arg Asp Ser 
465                 470                 475                 480 


Val Cys Ser Asn Ser Asn Ser Asn Asn Gly Lys Asn Gly Lys Asp Lys 
                485                 490                 495     


Glu Lys Glu Lys Gln Arg Lys Glu Lys Asp Lys Thr Arg Ala Asp Ser 
            500                 505                 510         


Val Ala Asn Lys Leu Gly Ser Phe Ser Lys Thr Leu Gly Ile Lys Leu 
        515                 520                 525             


Lys Lys Asn Met Gly Gly Leu Gly Gly Leu Val His Gly Lys Met Gly 
    530                 535                 540                 


Arg Ala Asn Ser Ala Asn Gly Lys Asn Gly Asp Ser Ala Glu Arg Gly 
545                 550                 555                 560 


Lys Glu Lys Lys Ala Lys Ser Arg Lys Gly Ser Lys Glu Glu Ser Gly 
                565                 570                 575     


Ala Ser Ala Ser Thr Ser Pro Ser Glu Lys Thr Thr Pro Ser Pro Thr 
            580                 585                 590         


Asp Lys Ala Ala Gly Ala Ser Pro Ala Glu Lys Gly Gly Gly Pro Arg 
        595                 600                 605             


Gly Asp Ala Trp Lys Tyr Ser Thr Asp Val Lys Leu Ser Leu Asn Ile 
    610                 615                 620                 


Leu Arg Ala Ala Met Gln Gly Glu Arg Lys Phe Ile Phe Ala Gly Leu 
625                 630                 635                 640 


Leu Leu Thr Ser His Arg His Gln Phe His Glu Glu Met Ile Gly Tyr 
                645                 650                 655     


Tyr Leu Thr Ser Ala Gln Glu Arg Phe Ser Ala Glu Gln Glu Gln Arg 
            660                 665                 670         


Arg Arg Asp Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        675                 680                 685             


Ala Thr Ala Lys Arg Pro Pro Arg Arg Pro Glu Thr Glu Gly Val Pro 
    690                 695                 700                 


Val Pro Glu Arg Ala Ser Pro Gly Pro Pro Thr Gln Leu Val Leu Lys 
705                 710                 715                 720 


Leu Lys Glu Arg Pro Ser Pro Gly Pro Ala Ala Gly Arg Ala Ala Arg 
                725                 730                 735     


Ala Ala Ala Gly Gly Thr Ala Ser Pro Gly Gly Gly Ala Arg Arg Ala 
            740                 745                 750         


Ser Ala Ser Gly Pro Val Pro Gly Arg Ser Pro Pro Ala Pro Ala Arg 
        755                 760                 765             


Gln Ser Val Ile His Val Gln Ala Ser Gly Ala Arg Asp Glu Ala Cys 
    770                 775                 780                 


Ala Pro Ala Val Gly Ala Leu Arg Pro Cys Ala Thr Tyr Pro Gln Gln 
785                 790                 795                 800 


Asn Arg Ser Leu Ser Ser Gln Ser Tyr Ser Pro Ala Arg Ala Ala Ala 
                805                 810                 815     


Leu Arg Thr Val Asn Thr Val Glu Ser Leu Ala Arg Ala Val Pro Gly 
            820                 825                 830         


Ala Leu Pro Gly Ala Ala Gly Thr Ala Gly Ala Ala Glu His Lys Ser 
        835                 840                 845             


Gln Thr Tyr Thr Asn Gly Phe Gly Ala Leu Arg Asp Gly Leu Glu Phe 
    850                 855                 860                 


Ala Asp Ala Asp Ala Pro Thr Ala Arg Ser Asn Gly Glu Cys Gly Arg 
865                 870                 875                 880 


Gly Gly Pro Gly Pro Val Gln Arg Arg Cys Gln Arg Glu Asn Cys Ala 
                885                 890                 895     


Phe Tyr Gly Arg Ala Glu Thr Glu His Tyr Cys Ser Tyr Cys Tyr Arg 
            900                 905                 910         


Glu Glu Leu Arg Arg Arg Arg Glu Ala Arg Gly Ala Arg Pro 
        915                 920                 925     


<210> 77
<211> 1113
<212> PRT
<213> Homo sapiens

<400> 77
Met Glu Ala Ala Val Gly Val Pro Asp Gly Gly Asp Gln Gly Gly Ala 
1               5                   10                  15      


Gly Pro Arg Glu Asp Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            20                  25                  30          


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        35                  40                  45              


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    50                  55                  60                  


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
65                  70                  75                  80  


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                85                  90                  95      


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            100                 105                 110         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        115                 120                 125             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    130                 135                 140                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser 
145                 150                 155                 160 


Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val 
                165                 170                 175     


Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu 
            180                 185                 190         


Val Ala Asp Glu Asp Asn Ser Glu Ile Ser Asp Ser Glu Asp Asp Ser 
        195                 200                 205             


Cys Lys Ser Lys Thr Ala Ala Ala Ala Ala Asp Val Asn Gly Phe Lys 
    210                 215                 220                 


Pro Leu Ser Gly Asn Glu Gln Leu Lys Asn Asn Gly Asn Ser Thr Ser 
225                 230                 235                 240 


Leu Pro Leu Ser Arg Lys Val Leu Lys Ser Leu Asn Pro Ala Val Tyr 
                245                 250                 255     


Arg Asn Val Glu Tyr Glu Ile Trp Leu Lys Ser Lys Gln Ala Gln Gln 
            260                 265                 270         


Lys Arg Asp Tyr Ser Ile Ala Ala Gly Leu Gln Tyr Glu Val Gly Asp 
        275                 280                 285             


Lys Cys Gln Val Arg Leu Asp His Asn Gly Lys Phe Leu Asn Ala Asp 
    290                 295                 300                 


Val Gln Gly Ile His Ser Glu Asn Gly Pro Val Leu Val Glu Glu Leu 
305                 310                 315                 320 


Gly Lys Lys His Thr Ser Lys Asn Leu Lys Ala Pro Pro Pro Glu Ser 
                325                 330                 335     


Trp Asn Thr Val Ser Gly Lys Lys Met Lys Lys Pro Ser Thr Ser Gly 
            340                 345                 350         


Gln Asn Phe His Ser Asp Val Asp Tyr Arg Gly Pro Lys Asn Pro Ser 
        355                 360                 365             


Lys Pro Ile Lys Ala Pro Ser Ala Leu Pro Pro Arg Leu Gln His Pro 
    370                 375                 380                 


Ser Gly Val Arg Gln His Ala Phe Ser Ser His Ser Ser Gly Ser Gln 
385                 390                 395                 400 


Ser Gln Lys Phe Ser Ser Glu His Lys Asn Leu Ser Arg Thr Pro Ser 
                405                 410                 415     


Gln Ile Ile Arg Lys Pro Asp Arg Glu Arg Val Glu Asp Phe Asp His 
            420                 425                 430         


Thr Ser Arg Glu Ser Asn Tyr Phe Gly Leu Ser Pro Glu Glu Arg Arg 
        435                 440                 445             


Glu Lys Gln Ala Ile Glu Glu Ser Arg Leu Leu Tyr Glu Ile Gln Asn 
    450                 455                 460                 


Arg Asp Glu Gln Ala Phe Pro Ala Leu Ser Ser Ser Ser Val Asn Gln 
465                 470                 475                 480 


Ser Ala Ser Gln Ser Ser Asn Pro Cys Val Gln Arg Lys Ser Ser His 
                485                 490                 495     


Val Gly Asp Arg Lys Gly Ser Arg Arg Arg Met Asp Thr Glu Glu Arg 
            500                 505                 510         


Lys Asp Lys Asp Ser Ile His Gly His Ser Gln Leu Asp Lys Arg Pro 
        515                 520                 525             


Glu Pro Ser Thr Leu Glu Asn Ile Thr Asp Asp Lys Tyr Ala Thr Val 
    530                 535                 540                 


Ser Ser Pro Ser Lys Ser Lys Lys Leu Glu Cys Pro Ser Pro Ala Glu 
545                 550                 555                 560 


Gln Lys Pro Ala Glu His Val Ser Leu Ser Asn Pro Ala Pro Leu Leu 
                565                 570                 575     


Val Ser Pro Glu Val His Leu Thr Pro Ala Val Pro Ser Leu Pro Ala 
            580                 585                 590         


Thr Val Pro Ala Trp Pro Ser Glu Pro Thr Thr Phe Gly Pro Thr Gly 
        595                 600                 605             


Val Pro Ala Pro Ile Pro Val Leu Ser Val Thr Gln Thr Leu Thr Thr 
    610                 615                 620                 


Gly Pro Asp Ser Ala Val Ser Gln Ala His Leu Thr Pro Ser Pro Val 
625                 630                 635                 640 


Pro Val Ser Ile Gln Ala Val Asn Gln Pro Leu Met Pro Leu Pro Gln 
                645                 650                 655     


Thr Leu Ser Leu Tyr Gln Asp Pro Leu Tyr Pro Gly Phe Pro Cys Asn 
            660                 665                 670         


Glu Lys Gly Asp Arg Ala Ile Val Pro Pro Tyr Ser Leu Cys Gln Thr 
        675                 680                 685             


Gly Glu Asp Leu Pro Lys Asp Lys Asn Ile Leu Arg Phe Phe Phe Asn 
    690                 695                 700                 


Leu Gly Val Lys Ala Tyr Ser Cys Pro Met Trp Ala Pro His Ser Tyr 
705                 710                 715                 720 


Leu Tyr Pro Leu His Gln Ala Tyr Leu Ala Ala Cys Arg Met Tyr Pro 
                725                 730                 735     


Lys Val Pro Val Pro Val Tyr Pro His Asn Pro Trp Phe Gln Glu Ala 
            740                 745                 750         


Pro Ala Ala Gln Asn Glu Ser Asp Cys Thr Cys Thr Asp Ala His Phe 
        755                 760                 765             


Pro Met Gln Thr Glu Ala Ser Val Asn Gly Gln Met Pro Gln Pro Glu 
    770                 775                 780                 


Ile Gly Pro Pro Thr Phe Ser Ser Pro Leu Val Ile Pro Pro Ser Gln 
785                 790                 795                 800 


Val Ser Glu Ser His Gly Gln Leu Ser Tyr Gln Ala Asp Leu Glu Ser 
                805                 810                 815     


Glu Thr Pro Gly Gln Leu Leu His Ala Asp Tyr Glu Glu Ser Leu Ser 
            820                 825                 830         


Gly Lys Asn Met Phe Pro Gln Ser Phe Gly Pro Asn Pro Phe Leu Gly 
        835                 840                 845             


Pro Val Pro Ile Ala Pro Pro Phe Phe Pro His Val Trp Tyr Gly Tyr 
    850                 855                 860                 


Pro Phe Gln Gly Phe Ile Glu Asn Pro Val Met Arg Gln Asn Ile Val 
865                 870                 875                 880 


Leu Pro Ser Asp Glu Lys Gly Glu Leu Asp Leu Ser Leu Glu Asn Leu 
                885                 890                 895     


Asp Leu Ser Lys Asp Cys Gly Ser Val Ser Thr Val Asp Glu Phe Pro 
            900                 905                 910         


Glu Ala Arg Gly Glu His Val His Ser Leu Pro Glu Ala Ser Val Ser 
        915                 920                 925             


Ser Lys Pro Asp Glu Gly Arg Thr Glu Gln Ser Ser Gln Thr Arg Lys 
    930                 935                 940                 


Ala Asp Thr Ala Leu Ala Ser Ile Pro Pro Val Ala Glu Gly Lys Ala 
945                 950                 955                 960 


His Pro Pro Thr Gln Ile Leu Asn Arg Glu Arg Glu Thr Val Pro Val 
                965                 970                 975     


Glu Leu Glu Pro Lys Arg Thr Ile Gln Ser Leu Lys Glu Lys Thr Glu 
            980                 985                 990         


Lys Val Lys Asp Pro Lys Thr Ala  Ala Asp Val Val Ser  Pro Gly Ala 
        995                 1000                 1005             


Asn Ser  Val Asp Ser Arg Val  Gln Arg Pro Lys Glu  Glu Ser Ser 
    1010                 1015                 1020             


Glu Asp  Glu Asn Glu Val Ser  Asn Ile Leu Arg Ser  Gly Arg Ser 
    1025                 1030                 1035             


Lys Gln  Phe Tyr Asn Gln Thr  Tyr Gly Ser Arg Lys  Tyr Lys Ser 
    1040                 1045                 1050             


Asp Trp  Gly Tyr Ser Gly Arg  Gly Gly Tyr Gln His  Val Arg Ser 
    1055                 1060                 1065             


Glu Glu  Ser Trp Lys Gly Gln  Pro Ser Arg Ser Arg  Asp Glu Gly 
    1070                 1075                 1080             


Tyr Gln  Tyr His Arg Asn Val  Arg Gly Arg Pro Phe  Arg Gly Asp 
    1085                 1090                 1095             


Arg Arg  Arg Ser Gly Met Gly  Asp Gly His Arg Gly  Gln His Thr 
    1100                 1105                 1110             


<210> 78
<211> 234
<212> PRT
<213> Homo sapiens

<400> 78
Met Ser Glu Thr Ser Phe Asn Leu Ile Ser Glu Lys Cys Asp Ile Leu 
1               5                   10                  15      


Ser Ile Leu Arg Asp His Pro Glu Asn Arg Ile Tyr Arg Arg Lys Ile 
            20                  25                  30          


Glu Glu Leu Ser Lys Arg Phe Thr Ala Ile Arg Lys Thr Lys Gly Asp 
        35                  40                  45              


Gly Asn Cys Phe Tyr Arg Ala Leu Gly Tyr Ser Tyr Leu Glu Ser Leu 
    50                  55                  60                  


Leu Gly Lys Ser Arg Glu Ile Phe Lys Phe Lys Glu Arg Val Leu Gln 
65                  70                  75                  80  


Thr Pro Asn Asp Leu Leu Ala Ala Gly Phe Glu Glu His Lys Phe Arg 
                85                  90                  95      


Asn Phe Phe Asn Ala Phe Tyr Ser Val Val Glu Leu Val Glu Lys Asp 
            100                 105                 110         


Gly Ser Val Ser Ser Leu Leu Lys Val Phe Asn Asp Gln Ser Ala Ser 
        115                 120                 125             


Asp His Ile Val Gln Phe Leu Arg Leu Leu Thr Ser Ala Phe Ile Arg 
    130                 135                 140                 


Asn Arg Ala Asp Phe Phe Arg His Phe Ile Asp Glu Glu Met Asp Ile 
145                 150                 155                 160 


Lys Asp Phe Cys Thr His Glu Val Glu Pro Met Ala Thr Glu Cys Asp 
                165                 170                 175     


His Ile Gln Ile Thr Ala Leu Ser Gln Ala Leu Ser Ile Ala Leu Gln 
            180                 185                 190         


Val Glu Tyr Val Asp Glu Met Asp Thr Ala Leu Asn His His Val Phe 
        195                 200                 205             


Pro Glu Ala Ala Thr Pro Ser Val Tyr Leu Leu Tyr Lys Thr Ser His 
    210                 215                 220                 


Tyr Asn Ile Leu Tyr Ala Ala Asp Lys His 
225                 230                 


<210> 79
<211> 398
<212> PRT
<213> Homo sapiens

<400> 79
Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 
1               5                   10                  15      


Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 
            20                  25                  30          


Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 
        35                  40                  45              


Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 
    50                  55                  60                  


Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 
65                  70                  75                  80  


Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 
                85                  90                  95      


Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 
            100                 105                 110         


Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 
        115                 120                 125             


Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 
    130                 135                 140                 


Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 
145                 150                 155                 160 


Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 
                165                 170                 175     


Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg Ile Asn Asp Asn 
            180                 185                 190         


Ser Glu Ala Pro Ala His Leu Gln Thr Asp Phe Gln Met Leu His Gln 
        195                 200                 205             


Asp Glu Ser Asn Lys Arg Glu Lys Ile Lys Thr Lys Gly Met Asp Ser 
    210                 215                 220                 


Glu Asp Asp Leu Arg Asp Glu Val Glu Asp Ala Val Gln Lys Val Cys 
225                 230                 235                 240 


Asn Ala Thr Gly Cys Ser Asp Phe Asn Leu Ile Val Gln Asn Leu Glu 
                245                 250                 255     


Ala Glu Asn Tyr Asn Ile Glu Ser Ala Ile Ile Ala Val Leu Arg Met 
            260                 265                 270         


Asn Gln Gly Lys Arg Asn Asn Ala Glu Glu Asn Leu Glu Pro Ser Gly 
        275                 280                 285             


Arg Val Leu Lys Gln Cys Gly Pro Leu Trp Glu Glu Gly Gly Ser Gly 
    290                 295                 300                 


Ala Arg Ile Phe Gly Asn Gln Gly Leu Asn Glu Gly Arg Thr Glu Asn 
305                 310                 315                 320 


Asn Lys Ala Gln Ala Ser Pro Ser Glu Glu Asn Lys Ala Asn Lys Asn 
                325                 330                 335     


Gln Leu Ala Lys Val Thr Asn Lys Gln Arg Arg Glu Gln Gln Trp Met 
            340                 345                 350         


Glu Lys Lys Lys Arg Gln Glu Glu Arg His Arg His Lys Ala Leu Glu 
        355                 360                 365             


Ser Arg Gly Ser His Arg Asp Asn Asn Arg Ser Glu Ala Glu Ala Asn 
    370                 375                 380                 


Thr Gln Val Thr Leu Val Lys Thr Phe Ala Ala Leu Asn Ile 
385                 390                 395             


<210> 80
<211> 843
<212> PRT
<213> Homo sapiens

<400> 80
Met Thr Leu Asp Met Asp Ala Val Leu Ser Asp Phe Val Arg Ser Thr 
1               5                   10                  15      


Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu Leu Glu Gly Lys Asn Trp 
            20                  25                  30          


Asp Val Asn Ala Ala Leu Ser Asp Phe Glu Gln Leu Arg Gln Val His 
        35                  40                  45              


Ala Gly Asn Leu Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
    50                  55                  60                  


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
65                  70                  75                  80  


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
                85                  90                  95      


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
            100                 105                 110         


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
        115                 120                 125             


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
    130                 135                 140                 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
145                 150                 155                 160 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
                165                 170                 175     


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
            180                 185                 190         


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
        195                 200                 205             


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
    210                 215                 220                 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
225                 230                 235                 240 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
                245                 250                 255     


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
            260                 265                 270         


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
        275                 280                 285             


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
    290                 295                 300                 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
305                 310                 315                 320 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
                325                 330                 335     


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
            340                 345                 350         


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys 
        355                 360                 365             


Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr 
    370                 375                 380                 


Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu 
385                 390                 395                 400 


Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu 
                405                 410                 415     


Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys 
            420                 425                 430         


Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln Pro Glu 
        435                 440                 445             


Ser Pro Thr Ala Ser Ala Gly Asp Glu Pro Arg Ser Thr Pro Glu Ser 
    450                 455                 460                 


Gly Asp Ser Asp Lys Glu Ser Val Gly Ser Ser Ser Thr Ser Asn Glu 
465                 470                 475                 480 


Gly Gly Arg Arg Lys Glu Lys Ser Lys Arg Asp Arg Glu Lys Asp Lys 
                485                 490                 495     


Lys Arg Ala Asp Ser Val Ala Asn Lys Leu Gly Ser Phe Gly Lys Thr 
            500                 505                 510         


Leu Gly Ser Lys Leu Lys Lys Asn Met Gly Gly Leu Met His Ser Lys 
        515                 520                 525             


Gly Ser Lys Pro Gly Gly Val Gly Thr Gly Leu Gly Gly Ser Ser Gly 
    530                 535                 540                 


Thr Glu Thr Leu Glu Lys Lys Lys Lys Asn Ser Leu Lys Ser Trp Lys 
545                 550                 555                 560 


Gly Gly Lys Glu Glu Ala Ala Gly Asp Gly Pro Val Ser Glu Lys Pro 
                565                 570                 575     


Pro Ala Glu Ser Val Gly Asn Gly Gly Ser Lys Tyr Ser Gln Glu Val 
            580                 585                 590         


Met Gln Ser Leu Ser Ile Leu Arg Thr Ala Met Gln Gly Glu Gly Lys 
        595                 600                 605             


Phe Ile Phe Val Gly Thr Leu Lys Met Gly His Arg His Gln Tyr Gln 
    610                 615                 620                 


Glu Glu Met Ile Gln Arg Tyr Leu Ser Asp Ala Glu Glu Arg Phe Leu 
625                 630                 635                 640 


Ala Glu Gln Lys Gln Lys Glu Ala Glu Arg Lys Ile Met Asn Gly Gly 
                645                 650                 655     


Ile Gly Gly Gly Pro Pro Pro Ala Lys Lys Pro Glu Pro Asp Ala Arg 
            660                 665                 670         


Glu Glu Gln Pro Thr Gly Pro Pro Ala Glu Ser Arg Ala Met Ala Phe 
        675                 680                 685             


Ser Thr Gly Tyr Pro Gly Asp Phe Thr Ile Pro Arg Pro Ser Gly Gly 
    690                 695                 700                 


Gly Val His Cys Gln Glu Pro Arg Arg Gln Leu Ala Gly Gly Pro Cys 
705                 710                 715                 720 


Val Gly Gly Leu Pro Pro Tyr Ala Thr Phe Pro Arg Gln Cys Pro Pro 
                725                 730                 735     


Gly Arg Pro Tyr Pro His Gln Asp Ser Ile Pro Ser Leu Glu Pro Gly 
            740                 745                 750         


Ser His Ser Lys Asp Gly Leu His Arg Gly Ala Leu Leu Pro Pro Pro 
        755                 760                 765             


Tyr Arg Val Ala Asp Ser Tyr Ser Asn Gly Tyr Arg Glu Pro Pro Glu 
    770                 775                 780                 


Pro Asp Gly Trp Ala Gly Gly Leu Arg Gly Leu Pro Pro Thr Gln Thr 
785                 790                 795                 800 


Lys Cys Lys Gln Pro Asn Cys Ser Phe Tyr Gly His Pro Glu Thr Asn 
                805                 810                 815     


Asn Phe Cys Ser Cys Cys Tyr Arg Glu Glu Leu Arg Arg Arg Glu Arg 
            820                 825                 830         


Glu Pro Asp Gly Glu Leu Leu Val His Arg Phe 
        835                 840             


<210> 81
<211> 571
<212> PRT
<213> Homo sapiens

<400> 81
Met Thr Ile Leu Pro Lys Lys Lys Pro Pro Pro Pro Asp Ala Asp Pro 
1               5                   10                  15      


Ala Asn Glu Pro Pro Pro Pro Gly Pro Met Pro Pro Ala Pro Arg Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Val Gly Gly Gly Gly Thr Gly Val Gly Gly Gly 
        35                  40                  45              


Asp Arg Asp Arg Asp Ser Gly Val Val Gly Ala Arg Pro Arg Ala Ser 
    50                  55                  60                  


Pro Pro Pro Gln Gly Pro Leu Pro Gly Pro Pro Gly Ala Leu His Arg 
65                  70                  75                  80  


Trp Ala Leu Ala Val Pro Pro Gly Ala Val Ala Gly Pro Arg Pro Gln 
                85                  90                  95      


Gln Ala Ser Pro Pro Pro Cys Gly Gly Pro Gly Gly Pro Gly Gly Gly 
            100                 105                 110         


Pro Gly Asp Ala Leu Gly Ala Ala Ala Ala Gly Val Gly Ala Ala Gly 
        115                 120                 125             


Val Val Val Gly Val Gly Gly Ala Val Gly Val Gly Gly Cys Cys Ser 
    130                 135                 140                 


Gly Pro Gly His Ser Lys Arg Arg Arg Gln Ala Pro Gly Val Gly Ala 
145                 150                 155                 160 


Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val Gly Ala Gly Tyr Asn 
                165                 170                 175     


Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg Ile Glu Ala Met Asp 
            180                 185                 190         


Pro Ala Thr Val Glu Gln Gln Glu His Trp Phe Glu Lys Ala Leu Arg 
        195                 200                 205             


Asp Lys Lys Gly Phe Ile Ile Lys Gln Met Lys Glu Asp Gly Ala Cys 
    210                 215                 220                 


Leu Phe Arg Ala Val Ala Asp Gln Val Tyr Gly Asp Gln Asp Met His 
225                 230                 235                 240 


Glu Val Val Arg Lys His Cys Met Asp Tyr Leu Met Lys Asn Ala Asp 
                245                 250                 255     


Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr Thr Tyr Ile Asn Arg 
            260                 265                 270         


Lys Arg Lys Asn Asn Cys His Gly Asn His Ile Glu Met Gln Ala Met 
        275                 280                 285             


Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gln Tyr Ser Thr Gly 
    290                 295                 300                 


Thr Ser Ala Val Glu Pro Ile Asn Thr Phe His Gly Ile His Gln Asn 
305                 310                 315                 320 


Glu Asp Glu Pro Ile Arg Val Ser Tyr His Arg Asn Ile His Tyr Asn 
                325                 330                 335     


Ser Val Val Asn Pro Asn Lys Ala Thr Ile Gly Val Gly Leu Gly Leu 
            340                 345                 350         


Pro Ser Phe Lys Pro Gly Phe Ala Glu Gln Ser Leu Met Lys Asn Ala 
        355                 360                 365             


Ile Lys Thr Ser Glu Glu Ser Trp Ile Glu Gln Gln Met Leu Glu Asp 
    370                 375                 380                 


Lys Lys Arg Ala Thr Asp Trp Glu Ala Thr Asn Glu Ala Ile Glu Glu 
385                 390                 395                 400 


Gln Val Ala Arg Glu Ser Tyr Leu Gln Trp Leu Arg Asp Gln Glu Lys 
                405                 410                 415     


Gln Ala Arg Gln Val Arg Gly Pro Ser Gln Pro Arg Lys Ala Ser Ala 
            420                 425                 430         


Thr Cys Ser Ser Ala Thr Ala Ala Ala Ser Ser Gly Leu Glu Glu Trp 
        435                 440                 445             


Thr Ser Arg Ser Pro Arg Gln Arg Ser Ser Ala Ser Ser Pro Glu His 
    450                 455                 460                 


Pro Glu Leu His Ala Glu Leu Gly Met Lys Pro Pro Ser Pro Gly Thr 
465                 470                 475                 480 


Val Leu Ala Leu Ala Lys Pro Pro Ser Pro Cys Ala Pro Gly Thr Ser 
                485                 490                 495     


Ser Gln Phe Ser Ala Gly Ala Asp Arg Ala Thr Ser Pro Leu Val Ser 
            500                 505                 510         


Leu Tyr Pro Ala Leu Glu Cys Arg Ala Leu Ile Gln Gln Met Ser Pro 
        515                 520                 525             


Ser Ala Phe Gly Leu Asn Asp Trp Asp Asp Asp Glu Ile Leu Ala Ser 
    530                 535                 540                 


Val Leu Ala Val Ser Gln Gln Glu Tyr Leu Asp Ser Met Lys Lys Asn 
545                 550                 555                 560 


Lys Val His Arg Asp Pro Pro Pro Asp Lys Ser 
                565                 570     


<210> 82
<211> 790
<212> PRT
<213> Homo sapiens

<400> 82
Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210> 83
<211> 708
<212> PRT
<213> Homo sapiens

<400> 83
Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu 
1               5                   10                  15      


Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala Gln Arg Pro 
            20                  25                  30          


Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp 
        35                  40                  45              


Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro 
    50                  55                  60                  


Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr 
65                  70                  75                  80  


Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu 
                85                  90                  95      


Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser Gln Arg Arg 
            100                 105                 110         


Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser Gly Ser Arg 
        115                 120                 125             


Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn 
    130                 135                 140                 


Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val Cys Thr Tyr 
145                 150                 155                 160 


Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg 
                165                 170                 175     


Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu Glu Ala Ser 
            180                 185                 190         


Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser 
        195                 200                 205             


Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser 
    210                 215                 220                 


Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly Ala Val Gly 
225                 230                 235                 240 


Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
                245                 250                 255     


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
            260                 265                 270         


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
        275                 280                 285             


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
    290                 295                 300                 


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
305                 310                 315                 320 


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
                325                 330                 335     


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
            340                 345                 350         


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
        355                 360                 365             


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
    370                 375                 380                 


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
385                 390                 395                 400 


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
                405                 410                 415     


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
            420                 425                 430         


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
        435                 440                 445             


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
    450                 455                 460                 


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
465                 470                 475                 480 


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
                485                 490                 495     


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
            500                 505                 510         


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
        515                 520                 525             


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
    530                 535                 540                 


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
545                 550                 555                 560 


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
                565                 570                 575     


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met 
            580                 585                 590         


Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr 
        595                 600                 605             


Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg 
    610                 615                 620                 


Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu 
625                 630                 635                 640 


Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr 
                645                 650                 655     


Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn 
            660                 665                 670         


His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg 
        675                 680                 685             


Gln Ile Arg Pro Cys Thr Ser Leu Ser Asp Gly Glu Glu Asp Glu Asp 
    690                 695                 700                 


Asp Glu Asp Glu 
705             


<210> 84
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 84
Met Ser Gln Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Glu Ala Pro Gln Thr Pro Ser Ser Leu Ala Ser Ala Ala Ala 
            20                  25                  30          


Ser Gly Gly Leu Leu Lys Arg Arg Asp Arg Arg Ile Leu Ser Gly Ser 
        35                  40                  45              


Cys Pro Asp Pro Lys Cys Gln Ala Arg Leu Phe Phe Pro Ala Ser Gly 
    50                  55                  60                  


Ser Val Ser Ile Glu Cys Thr Glu Cys Gly Gln Arg His Glu Gln Gln 
65                  70                  75                  80  


Gln Leu Leu Gly Val Glu Glu Val Thr Asp Pro Asp Val Val Leu His 
                85                  90                  95      


Asn Leu Leu Arg Asn Ala Leu Leu Gly Val Thr Gly Ala Pro Lys Lys 
            100                 105                 110         


Asn Thr Glu Leu Val Lys Val Met Gly Leu Ser Asn Tyr His Cys Lys 
        115                 120                 125             


Leu Leu Ser Pro Ile Leu Ala Arg Tyr Gly Met Asp Lys Gln Thr Gly 
    130                 135                 140                 


Arg Ala Lys Leu Leu Arg Asp Met Asn Gln Gly Glu Leu Phe Asp Cys 
145                 150                 155                 160 


Ala Leu Leu Gly Asp Arg Ala Phe Leu Ile Glu Pro Glu His Val Asn 
                165                 170                 175     


Thr Val Gly Tyr Gly Lys Asp Arg Ser Gly Ser Leu Leu Tyr Leu His 
            180                 185                 190         


Asp Thr Leu Glu Asp Ile Lys Arg Ala Asn Lys Ser Gln Glu Cys Leu 
        195                 200                 205             


Ile Pro Val His Val Asp Gly Asp Gly His Cys Leu Val His Ala Val 
    210                 215                 220                 


Ser Arg Ala Leu Val Gly Arg Glu Leu Phe Trp His Ala Leu Arg Glu 
225                 230                 235                 240 


Asn Leu Lys Gln His Phe Gln Gln His Leu Ala Arg Tyr Gln Ala Leu 
                245                 250                 255     


Phe His Asp Phe Ile Asp Ala Ala Glu Trp Glu Asp Ile Ile Asn Glu 
            260                 265                 270         


Cys Asp Pro Leu Phe Val Pro Pro Glu Gly Val Pro Leu Gly Leu Arg 
        275                 280                 285             


Asn Ile His Ile Phe Gly Leu Ala Asn Val Leu His Arg Pro Ile Ile 
    290                 295                 300                 


Leu Leu Asp Ser Leu Ser Gly Met Arg Ser Ser Gly Asp Tyr Ser Ala 
305                 310                 315                 320 


Thr Phe Leu Pro Gly Leu Ile Pro Ala Glu Lys Cys Thr Gly Lys Asp 
                325                 330                 335     


Gly His Leu Asn Lys Pro Ile Cys Ile Ala Trp Ser Ser Ser Gly Arg 
            340                 345                 350         


Asn His Tyr Ile Pro Leu Val Gly Ile Lys Gly Ala Ala Leu Pro Lys 
        355                 360                 365             


Leu Pro Met Asn Leu Leu Pro Lys Ala Trp Gly Val Pro Gln Asp Leu 
    370                 375                 380                 


Ile Lys Lys Tyr Ile Lys Leu Glu Glu Asp Gly Gly Cys Val Ile Gly 
385                 390                 395                 400 


Gly Asp Arg Ser Leu Gln Asp Lys Tyr Leu Leu Arg Leu Val Ala Ala 
                405                 410                 415     


Met Glu Glu Val Phe Met Asp Lys His Gly Ile His Pro Ser Leu Val 
            420                 425                 430         


Ala Asp Val His Gln Tyr Phe Tyr Arg Arg Thr Gly Val Ile Gly Val 
        435                 440                 445             


Gln Pro Glu Glu Val Thr Ala Ala Ala Lys Lys Ala Val Met Asp Asn 
    450                 455                 460                 


Arg Leu His Lys Cys Leu Leu Cys Gly Ala Leu Ser Glu Leu His Val 
465                 470                 475                 480 


Pro Pro Glu Trp Leu Ala Pro Gly Gly Lys Leu Tyr Asn Leu Ala Lys 
                485                 490                 495     


Ser Thr His Gly Gln Leu Arg Thr Asp Lys Asn Tyr Ser Phe Pro Leu 
            500                 505                 510         


Asn Asn Leu Val Cys Ser Tyr Asp Ser Val Lys Asp Val Leu Val Pro 
        515                 520                 525             


Asp Tyr Gly Met Ser Asn Leu Thr Ala Cys Asn Trp Cys His Gly Thr 
    530                 535                 540                 


Ser Val Arg Lys Val Arg Gly Asp Gly Ser Ile Val Tyr Leu Asp Gly 
545                 550                 555                 560 


Asp Arg Thr Asn Ser Arg Ser Thr Gly Gly Lys Cys Gly Cys Gly Phe 
                565                 570                 575     


Lys His Phe Trp Asp Gly Lys Glu Tyr Asp Asn Leu Pro Glu Ala Phe 
            580                 585                 590         


Pro Ile Thr Leu Glu Trp Gly Gly Arg Val Val Arg Glu Thr Val Tyr 
        595                 600                 605             


Trp Phe Gln Tyr Glu Ser Asp Ser Ser Leu Asn Ser Asn Val Tyr Asp 
    610                 615                 620                 


Val Ala Met Lys Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser 
625                 630                 635                 640 


Glu Ile Leu Val Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala 
                645                 650                 655     


Lys Lys Asn Pro Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His 
            660                 665                 670         


Ala Gln Arg Val Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu 
        675                 680                 685             


Pro Thr Lys Ile Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys 
    690                 695                 700                 


Glu Glu Leu Asn Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile 
705                 710                 715                 720 


Thr Glu Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys 
                725                 730                 735     


Gln Glu Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg 
            740                 745                 750         


Asp Gly Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser 
        755                 760                 765             


Pro Thr Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly 
    770                 775                 780                 


Arg Gln Ser Met Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu 
785                 790                 795                 800 


Gln Glu Ser Ile Ala Arg Glu Phe Asn Ile Pro Pro Tyr Leu Gln Cys 
                805                 810                 815     


Ile Arg Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly 
            820                 825                 830         


Met Glu Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile 
        835                 840                 845             


Glu Ile Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His 
    850                 855                 860                 


Ser Ala His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu 
865                 870                 875                 880 


Ser Ser Lys Glu Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu 
                885                 890                 895     


Cys Leu Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys 
            900                 905                 910         


Gly Leu Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met 
        915                 920                 925             


Lys Lys Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His 
    930                 935                 940                 


Leu Pro Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu 
945                 950                 955                 960 


Leu Cys Val Asp Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu 
                965                 970                 975     


Asp Leu Val Lys Glu Ala Val Ser Gln Val Arg Ala Glu Ala Thr Thr 
            980                 985                 990         


Arg Ser Arg Glu Ser Ser Pro Ser  His Gly Leu Leu Lys  Leu Gly Ser 
        995                 1000                 1005             


Gly Gly  Val Val Lys Lys Lys  Ser Glu Gln Leu His  Asn Val Thr 
    1010                 1015                 1020             


Ala Phe  Gln Gly Lys Gly His  Ser Leu Gly Thr Ala  Ser Gly Asn 
    1025                 1030                 1035             


Pro His  Leu Asp Pro Arg Ala  Arg Glu Thr Ser Val  Val Arg Lys 
    1040                 1045                 1050             


His Asn  Thr Gly Thr Asp Phe  Ser Asn Ser Ser Thr  Lys Thr Glu 
    1055                 1060                 1065             


Pro Ser  Val Phe Thr Ala Ser  Ser Ser Asn Ser Glu  Leu Ile Arg 
    1070                 1075                 1080             


Ile Ala  Pro Gly Val Val Thr  Met Arg Asp Gly Arg  Gln Leu Asp 
    1085                 1090                 1095             


Pro Asp  Leu Val Glu Ala Gln  Arg Lys Lys Leu Gln  Glu Met Val 
    1100                 1105                 1110             


Ser Ser  Ile Gln Ala Ser Met  Asp Arg His Leu Arg  Asp Gln Ser 
    1115                 1120                 1125             


Thr Glu  Gln Ser Pro Ser Asp  Leu Pro Gln Arg Lys  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Ser Ser Ala Lys Ser  Gly Ser Leu Gln Thr  Gly Leu Pro 
    1145                 1150                 1155             


Glu Ser  Phe Pro Leu Thr Gly  Gly Thr Glu Asn Leu  Asn Thr Glu 
    1160                 1165                 1170             


Thr Thr  Asp Gly Cys Val Ala  Asp Ala Leu Gly Ala  Ala Phe Ala 
    1175                 1180                 1185             


Thr Arg  Ser Lys Ala Gln Arg  Gly Asn Ser Val Glu  Glu Leu Glu 
    1190                 1195                 1200             


Glu Met  Asp Ser Gln Asp Ala  Glu Met Thr Asn Thr  Thr Glu Pro 
    1205                 1210                 1215             


Met Asp  His Ser 
    1220         


<210> 85
<211> 230
<212> PRT
<213> Homo sapiens

<400> 85
Met Glu Gly Gln Arg Trp Leu Pro Leu Glu Ala Asn Pro Glu Val Thr 
1               5                   10                  15      


Asn Gln Phe Leu Lys Gln Leu Gly Leu His Pro Asn Trp Gln Phe Val 
            20                  25                  30          


Asp Val Tyr Gly Met Asp Pro Glu Leu Leu Ser Met Val Pro Arg Pro 
        35                  40                  45              


Val Cys Ala Val Leu Leu Leu Phe Pro Ile Thr Glu Lys Tyr Glu Val 
    50                  55                  60                  


Phe Arg Thr Glu Glu Glu Glu Lys Ile Lys Ser Gln Gly Gln Asp Val 
65                  70                  75                  80  


Thr Ser Ser Val Tyr Phe Met Lys Gln Thr Ile Ser Asn Ala Cys Gly 
                85                  90                  95      


Thr Ile Gly Leu Ile His Ala Ile Ala Asn Asn Lys Asp Lys Met His 
            100                 105                 110         


Phe Glu Ser Gly Ser Thr Leu Lys Lys Phe Leu Glu Glu Ser Val Ser 
        115                 120                 125             


Met Ser Pro Glu Glu Arg Ala Arg Tyr Leu Glu Asn Tyr Asp Ala Ile 
    130                 135                 140                 


Arg Val Thr His Glu Thr Ser Ala His Glu Gly Gln Thr Glu Ala Pro 
145                 150                 155                 160 


Ser Ile Asp Glu Lys Val Asp Leu His Phe Ile Ala Leu Val His Val 
                165                 170                 175     


Asp Gly His Leu Tyr Glu Leu Asp Gly Arg Lys Pro Phe Pro Ile Asn 
            180                 185                 190         


His Gly Glu Thr Ser Asp Glu Thr Leu Leu Glu Asp Ala Ile Glu Val 
        195                 200                 205             


Cys Lys Lys Phe Met Glu Arg Asp Pro Asp Glu Leu Arg Phe Asn Ala 
    210                 215                 220                 


Ile Ala Leu Ser Ala Ala 
225                 230 


<210> 86
<211> 223
<212> PRT
<213> Homo sapiens

<400> 86
Met Gln Leu Lys Pro Met Glu Ile Asn Pro Glu Met Leu Asn Lys Val 
1               5                   10                  15      


Leu Ser Arg Leu Gly Val Ala Gly Gln Trp Arg Phe Val Asp Val Leu 
            20                  25                  30          


Gly Leu Glu Glu Glu Ser Leu Gly Ser Val Pro Ala Pro Ala Cys Ala 
        35                  40                  45              


Leu Leu Leu Leu Phe Pro Leu Thr Ala Gln His Glu Asn Phe Arg Lys 
    50                  55                  60                  


Lys Gln Ile Glu Glu Leu Lys Gly Gln Glu Val Ser Pro Lys Val Tyr 
65                  70                  75                  80  


Phe Met Lys Gln Thr Ile Gly Asn Ser Cys Gly Thr Ile Gly Leu Ile 
                85                  90                  95      


His Ala Val Ala Asn Asn Gln Asp Lys Leu Gly Phe Glu Asp Gly Ser 
            100                 105                 110         


Val Leu Lys Gln Phe Leu Ser Glu Thr Glu Lys Met Ser Pro Glu Asp 
        115                 120                 125             


Arg Ala Lys Cys Phe Glu Lys Asn Glu Ala Ile Gln Ala Ala His Asp 
    130                 135                 140                 


Ala Val Ala Gln Glu Gly Gln Cys Arg Val Asp Asp Lys Val Asn Phe 
145                 150                 155                 160 


His Phe Ile Leu Phe Asn Asn Val Asp Gly His Leu Tyr Glu Leu Asp 
                165                 170                 175     


Gly Arg Met Pro Phe Pro Val Asn His Gly Ala Ser Ser Glu Asp Thr 
            180                 185                 190         


Leu Leu Lys Asp Ala Ala Lys Val Cys Arg Glu Phe Thr Glu Arg Glu 
        195                 200                 205             


Gln Gly Glu Val Arg Phe Ser Ala Val Ala Leu Cys Lys Ala Ala 
    210                 215                 220             


<210> 87
<211> 329
<212> PRT
<213> Homo sapiens

<400> 87
Met Thr Gly Asn Ala Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly 
1               5                   10                  15      


Val Phe Thr Glu Leu Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val 
            20                  25                  30          


Glu Glu Ile Trp Ser Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro 
        35                  40                  45              


Val His Gly Leu Ile Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro 
    50                  55                  60                  


Ala Gly Ser Val Val Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala 
65                  70                  75                  80  


Lys Gln Val Ile Asn Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val 
                85                  90                  95      


Leu Leu Asn Cys Thr His Gln Asp Val His Leu Gly Glu Thr Leu Ser 
            100                 105                 110         


Glu Phe Lys Glu Phe Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu 
        115                 120                 125             


Ala Leu Ser Asn Ser Asp Val Ile Arg Gln Val His Asn Ser Phe Ala 
    130                 135                 140                 


Arg Gln Gln Met Phe Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu 
145                 150                 155                 160 


Asp Ala Phe His Phe Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr 
                165                 170                 175     


Glu Leu Asp Gly Leu Arg Glu Gly Pro Ile Asp Leu Gly Ala Cys Asn 
            180                 185                 190         


Gln Asp Asp Trp Ile Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile 
        195                 200                 205             


Gln Lys Tyr Ser Glu Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val 
    210                 215                 220                 


Ser Asp Arg Lys Met Ile Tyr Glu Gln Lys Ile Ala Glu Leu Gln Arg 
225                 230                 235                 240 


Gln Leu Ala Glu Glu Glu Pro Met Asp Thr Asp Gln Gly Asn Ser Met 
                245                 250                 255     


Leu Ser Ala Ile Gln Ser Glu Val Ala Lys Asn Gln Met Leu Ile Glu 
            260                 265                 270         


Glu Glu Val Gln Lys Leu Lys Arg Tyr Lys Ile Glu Asn Ile Arg Arg 
        275                 280                 285             


Lys His Asn Tyr Leu Pro Phe Ile Met Glu Leu Leu Lys Thr Leu Ala 
    290                 295                 300                 


Glu His Gln Gln Leu Ile Pro Leu Val Glu Lys Ala Lys Glu Lys Gln 
305                 310                 315                 320 


Asn Ala Lys Lys Ala Gln Glu Thr Lys 
                325                 


<210> 88
<211> 361
<212> PRT
<213> Homo sapiens

<400> 88
Met Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser 
                85                  90                  95      


Pro Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys 
        115                 120                 125             


Gln Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr 
145                 150                 155                 160 


Ser Ile Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Met Ile Arg Val Gln Gln Met His Arg Pro Lys Leu Ile 
            180                 185                 190         


Gly Glu Glu Leu Ala Gln Leu Lys Glu Gln Arg Val His Lys Thr Asp 
        195                 200                 205             


Leu Glu Arg Val Leu Glu Ala Asn Asp Gly Ser Gly Met Leu Asp Glu 
    210                 215                 220                 


Asp Glu Glu Asp Leu Gln Arg Ala Leu Ala Leu Ser Arg Gln Glu Ile 
225                 230                 235                 240 


Asp Met Glu Asp Glu Glu Ala Asp Leu Arg Arg Ala Ile Gln Leu Ser 
                245                 250                 255     


Met Gln Gly Ser Ser Arg Asn Ile Ser Gln Asp Met Thr Gln Thr Ser 
            260                 265                 270         


Gly Thr Asn Leu Thr Ser Glu Glu Leu Arg Lys Arg Arg Glu Ala Tyr 
        275                 280                 285             


Phe Glu Lys Gln Gln Gln Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gly Asp Leu Ser Gly Gln Ser Ser His Pro Cys Glu Arg Pro Ala 
305                 310                 315                 320 


Thr Ser Ser Gly Ala Leu Gly Ser Asp Leu Gly Asp Ala Met Ser Glu 
                325                 330                 335     


Glu Asp Met Leu Gln Ala Ala Val Thr Met Ser Leu Glu Thr Val Arg 
            340                 345                 350         


Asn Asp Leu Lys Thr Glu Gly Lys Lys 
        355                 360     


<210> 89
<211> 188
<212> PRT
<213> Homo sapiens

<400> 89
Met Ser Gln Ala Pro Gly Ala Gln Pro Ser Pro Pro Thr Val Tyr His 
1               5                   10                  15      


Glu Arg Gln Arg Leu Glu Leu Cys Ala Val His Ala Leu Asn Asn Val 
            20                  25                  30          


Leu Gln Gln Gln Leu Phe Ser Gln Glu Ala Ala Asp Glu Ile Cys Lys 
        35                  40                  45              


Arg Leu Ala Pro Asp Ser Arg Leu Asn Pro His Arg Ser Leu Leu Gly 
    50                  55                  60                  


Thr Gly Asn Tyr Asp Val Asn Val Ile Met Ala Ala Leu Gln Gly Leu 
65                  70                  75                  80  


Gly Leu Ala Ala Val Trp Trp Asp Arg Arg Arg Pro Leu Ser Gln Leu 
                85                  90                  95      


Ala Leu Pro Gln Val Leu Gly Leu Ile Leu Asn Leu Pro Ser Pro Val 
            100                 105                 110         


Ser Leu Gly Leu Leu Ser Leu Pro Leu Arg Arg Arg His Trp Val Ala 
        115                 120                 125             


Leu Arg Gln Val Asp Gly Val Tyr Tyr Asn Leu Asp Ser Lys Leu Arg 
    130                 135                 140                 


Ala Pro Glu Ala Leu Gly Asp Glu Asp Gly Val Arg Ala Phe Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Ala Gln Gly Leu Cys Glu Val Leu Leu Val Val Thr Lys 
                165                 170                 175     


Glu Val Glu Glu Lys Gly Ser Trp Leu Arg Thr Asp 
            180                 185             


<210> 90
<211> 202
<212> PRT
<213> Homo sapiens

<400> 90
Met Ser Cys Val Pro Trp Lys Gly Asp Lys Ala Lys Ser Glu Ser Leu 
1               5                   10                  15      


Glu Leu Pro Gln Ala Ala Pro Pro Gln Ile Tyr His Glu Lys Gln Arg 
            20                  25                  30          


Arg Glu Leu Cys Ala Leu His Ala Leu Asn Asn Val Phe Gln Asp Ser 
        35                  40                  45              


Asn Ala Phe Thr Arg Asp Thr Leu Gln Glu Ile Phe Gln Arg Leu Ser 
    50                  55                  60                  


Pro Asn Thr Met Val Thr Pro His Lys Lys Ser Met Leu Gly Asn Gly 
65                  70                  75                  80  


Asn Tyr Asp Val Asn Val Ile Met Ala Ala Leu Gln Thr Lys Gly Tyr 
                85                  90                  95      


Glu Ala Val Trp Trp Asp Lys Arg Arg Asp Val Gly Val Ile Ala Leu 
            100                 105                 110         


Thr Asn Val Met Gly Phe Ile Met Asn Leu Pro Ser Ser Leu Cys Trp 
        115                 120                 125             


Gly Pro Leu Lys Leu Pro Leu Lys Arg Gln His Trp Ile Cys Val Arg 
    130                 135                 140                 


Glu Val Gly Gly Ala Tyr Tyr Asn Leu Asp Ser Lys Leu Lys Met Pro 
145                 150                 155                 160 


Glu Trp Ile Gly Gly Glu Ser Glu Leu Arg Lys Phe Leu Lys His His 
                165                 170                 175     


Leu Arg Gly Lys Asn Cys Glu Leu Leu Leu Val Val Pro Glu Glu Val 
            180                 185                 190         


Glu Ala His Gln Ser Trp Arg Thr Asp Val 
        195                 200         


<210> 91
<211> 355
<212> PRT
<213> Homo sapiens

<400> 91
Met Asp Phe Ile Phe His Glu Lys Gln Glu Gly Phe Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ala Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Glu Tyr Leu Ala Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Glu Asn Met Asp Asp Thr Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Phe Trp Gly Leu Glu Ile Ile His Phe Asn Asn 
                85                  90                  95      


Pro Glu Tyr Gln Lys Leu Gly Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Gln His Trp Phe Thr Ile Arg Lys Phe Gly Lys 
        115                 120                 125             


His Trp Phe Asn Leu Asn Ser Leu Leu Ala Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Cys Leu Ala Asn Phe Leu Ala Arg Leu Gln Gln Gln Ala Tyr 
145                 150                 155                 160 


Ser Val Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Ile Ile Ser Val Glu Glu Met Asp Thr Pro Lys Leu Asn 
            180                 185                 190         


Gly Lys Lys Leu Val Lys Gln Lys Glu His Arg Val Tyr Lys Thr Val 
        195                 200                 205             


Leu Glu Lys Val Ser Glu Glu Ser Asp Glu Ser Gly Thr Ser Asp Gln 
    210                 215                 220                 


Asp Glu Glu Asp Phe Gln Arg Ala Leu Glu Leu Ser Arg Gln Glu Thr 
225                 230                 235                 240 


Asn Arg Glu Asp Glu His Leu Arg Ser Thr Ile Glu Leu Ser Met Gln 
                245                 250                 255     


Gly Ser Ser Gly Asn Thr Ser Gln Asp Leu Pro Lys Thr Ser Cys Val 
            260                 265                 270         


Thr Pro Ala Ser Glu Gln Pro Lys Lys Ile Lys Glu Asp Tyr Phe Glu 
        275                 280                 285             


Lys His Gln Gln Glu Gln Lys Gln Gln Gln Gln Gln Ser Asp Leu Pro 
    290                 295                 300                 


Gly His Ser Ser Tyr Leu His Glu Arg Pro Thr Thr Ser Ser Arg Ala 
305                 310                 315                 320 


Ile Glu Ser Asp Leu Ser Asp Asp Ile Ser Glu Gly Thr Val Gln Ala 
                325                 330                 335     


Ala Val Asp Thr Ile Leu Glu Ile Met Arg Lys Asn Leu Lys Ile Lys 
            340                 345                 350         


Gly Glu Lys 
        355 


<210> 92
<211> 445
<212> PRT
<213> Homo sapiens

<400> 92
Met Ser Glu Leu Thr Lys Glu Leu Met Glu Leu Val Trp Gly Thr Lys 
1               5                   10                  15      


Ser Ser Pro Gly Leu Ser Asp Thr Ile Phe Cys Arg Trp Thr Gln Gly 
            20                  25                  30          


Phe Val Phe Ser Glu Ser Glu Gly Ser Ala Leu Glu Gln Phe Glu Gly 
        35                  40                  45              


Gly Pro Cys Ala Val Ile Ala Pro Val Gln Ala Phe Leu Leu Lys Lys 
    50                  55                  60                  


Leu Leu Phe Ser Ser Glu Lys Ser Ser Trp Arg Asp Cys Ser Glu Glu 
65                  70                  75                  80  


Glu Gln Lys Glu Leu Leu Cys His Thr Leu Cys Asp Ile Leu Glu Ser 
                85                  90                  95      


Ala Cys Cys Asp His Ser Gly Ser Tyr Cys Leu Val Ser Trp Leu Arg 
            100                 105                 110         


Gly Lys Thr Thr Glu Glu Thr Ala Ser Ile Ser Gly Ser Pro Ala Glu 
        115                 120                 125             


Ser Ser Cys Gln Val Glu His Ser Ser Ala Leu Ala Val Glu Glu Leu 
    130                 135                 140                 


Gly Phe Glu Arg Phe His Ala Leu Ile Gln Lys Arg Ser Phe Arg Ser 
145                 150                 155                 160 


Leu Pro Glu Leu Lys Asp Ala Val Leu Asp Gln Tyr Ser Met Trp Gly 
                165                 170                 175     


Asn Lys Phe Gly Val Leu Leu Phe Leu Tyr Ser Val Leu Leu Thr Lys 
            180                 185                 190         


Gly Ile Glu Asn Ile Lys Asn Glu Ile Glu Asp Ala Ser Glu Pro Leu 
        195                 200                 205             


Ile Asp Pro Val Tyr Gly His Gly Ser Gln Ser Leu Ile Asn Leu Leu 
    210                 215                 220                 


Leu Thr Gly His Ala Val Ser Asn Val Trp Asp Gly Asp Arg Glu Cys 
225                 230                 235                 240 


Ser Gly Met Lys Leu Leu Gly Ile His Glu Gln Ala Ala Val Gly Phe 
                245                 250                 255     


Leu Thr Leu Met Glu Ala Leu Arg Tyr Cys Lys Val Gly Ser Tyr Leu 
            260                 265                 270         


Lys Ser Pro Lys Phe Pro Ile Trp Ile Val Gly Ser Glu Thr His Leu 
        275                 280                 285             


Thr Val Phe Phe Ala Lys Asp Met Ala Leu Val Ala Pro Glu Ala Pro 
    290                 295                 300                 


Ser Glu Gln Ala Arg Arg Val Phe Gln Thr Tyr Asp Pro Glu Asp Asn 
305                 310                 315                 320 


Gly Phe Ile Pro Asp Ser Leu Leu Glu Asp Val Met Lys Ala Leu Asp 
                325                 330                 335     


Leu Val Ser Asp Pro Glu Tyr Ile Asn Leu Met Lys Asn Lys Leu Asp 
            340                 345                 350         


Pro Glu Gly Leu Gly Ile Ile Leu Leu Gly Pro Phe Leu Gln Glu Phe 
        355                 360                 365             


Phe Pro Asp Gln Gly Ser Ser Gly Pro Glu Ser Phe Thr Val Tyr His 
    370                 375                 380                 


Tyr Asn Gly Leu Lys Gln Ser Asn Tyr Asn Glu Lys Val Met Tyr Val 
385                 390                 395                 400 


Glu Gly Thr Ala Val Val Met Gly Phe Glu Asp Pro Met Leu Gln Thr 
                405                 410                 415     


Asp Asp Thr Pro Ile Lys Arg Cys Leu Gln Thr Lys Trp Pro Tyr Ile 
            420                 425                 430         


Glu Leu Leu Trp Thr Thr Asp Arg Ser Pro Ser Leu Asn 
        435                 440                 445 


<210> 93
<211> 469
<212> PRT
<213> Homo sapiens

<400> 93
Met Glu Tyr His Gln Pro Glu Asp Pro Ala Pro Gly Lys Ala Gly Thr 
1               5                   10                  15      


Ala Glu Ala Val Ile Pro Glu Asn His Glu Val Leu Ala Gly Pro Asp 
            20                  25                  30          


Glu His Pro Gln Asp Thr Asp Ala Arg Asp Ala Asp Gly Glu Ala Arg 
        35                  40                  45              


Glu Arg Glu Pro Ala Asp Gln Ala Leu Leu Pro Ser Gln Cys Gly Asp 
    50                  55                  60                  


Asn Leu Glu Ser Pro Leu Pro Glu Ala Ser Ser Ala Pro Pro Gly Pro 
65                  70                  75                  80  


Thr Leu Gly Thr Leu Pro Glu Val Glu Thr Ile Arg Ala Cys Ser Met 
                85                  90                  95      


Pro Gln Glu Leu Pro Gln Ser Pro Arg Thr Arg Gln Pro Glu Pro Asp 
            100                 105                 110         


Phe Tyr Cys Val Lys Trp Ile Pro Trp Lys Gly Glu Gln Thr Pro Ile 
        115                 120                 125             


Ile Thr Gln Ser Thr Asn Gly Pro Cys Pro Leu Leu Ala Ile Met Asn 
    130                 135                 140                 


Ile Leu Phe Leu Gln Trp Lys Val Lys Leu Pro Pro Gln Lys Glu Val 
145                 150                 155                 160 


Ile Thr Ser Asp Glu Leu Met Ala His Leu Gly Asn Cys Leu Leu Ser 
                165                 170                 175     


Ile Lys Pro Gln Glu Lys Ser Glu Gly Leu Gln Leu Asn Phe Gln Gln 
            180                 185                 190         


Asn Val Asp Asp Ala Met Thr Val Leu Pro Lys Leu Ala Thr Gly Leu 
        195                 200                 205             


Asp Val Asn Val Arg Phe Thr Gly Val Ser Asp Phe Glu Tyr Thr Pro 
    210                 215                 220                 


Glu Cys Ser Val Phe Asp Leu Leu Gly Ile Pro Leu Tyr His Gly Trp 
225                 230                 235                 240 


Leu Val Asp Pro Gln Ser Pro Glu Ala Val Arg Ala Val Gly Lys Leu 
                245                 250                 255     


Ser Tyr Asn Gln Leu Val Glu Arg Ile Ile Thr Cys Lys His Ser Ser 
            260                 265                 270         


Asp Thr Asn Leu Val Thr Glu Gly Leu Ile Ala Glu Gln Phe Leu Glu 
        275                 280                 285             


Thr Thr Ala Ala Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ala 
    290                 295                 300                 


Ala Ala Lys Glu Gly Glu Leu Ser Val Phe Phe Arg Asn Asn His Phe 
305                 310                 315                 320 


Ser Thr Met Thr Lys His Lys Ser His Leu Tyr Leu Leu Val Thr Asp 
                325                 330                 335     


Gln Gly Phe Leu Gln Glu Glu Gln Val Val Trp Glu Ser Leu His Asn 
            340                 345                 350         


Val Asp Gly Asp Ser Cys Phe Cys Asp Ser Asp Phe His Leu Ser His 
        355                 360                 365             


Ser Leu Gly Lys Gly Pro Gly Ala Glu Gly Gly Ser Gly Ser Pro Glu 
    370                 375                 380                 


Thr Gln Leu Gln Val Asp Gln Asp Tyr Leu Ile Ala Leu Ser Leu Gln 
385                 390                 395                 400 


Gln Gln Gln Pro Arg Gly Pro Leu Gly Leu Thr Asp Leu Glu Leu Ala 
                405                 410                 415     


Gln Gln Leu Gln Gln Glu Glu Tyr Gln Gln Gln Gln Ala Ala Gln Pro 
            420                 425                 430         


Val Arg Met Arg Thr Arg Val Leu Ser Leu Gln Gly Arg Gly Ala Thr 
        435                 440                 445             


Ser Gly Arg Pro Ala Gly Glu Arg Arg Gln Arg Pro Lys His Glu Ser 
    450                 455                 460                 


Asp Cys Ile Leu Leu 
465                 


<210> 94
<211> 621
<212> PRT
<213> Homo sapiens

<400> 94
Met Glu Ser Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala 
1               5                   10                  15      


Ala Gly Pro Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu 
            20                  25                  30          


Thr Arg Leu Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr 
        35                  40                  45              


Ser Gly Gly Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro 
    50                  55                  60                  


Asp Ser Ala Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser 
65                  70                  75                  80  


Ser Ser Ala Gly Leu Asp Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala 
                85                  90                  95      


Ala Ala Glu Ala Pro Leu Arg Gly Gln Tyr Lys Val Thr Ala Ser Pro 
            100                 105                 110         


Glu Thr Ala Val Ala Gly Val Gly His Glu Leu Gly Thr Ala Gly Asp 
        115                 120                 125             


Ala Gly Ala Arg Pro Asp Leu Ala Gly Thr Cys Gln Ala Glu Leu Thr 
    130                 135                 140                 


Ala Ala Gly Ser Glu Glu Pro Ser Ser Ala Gly Gly Leu Ser Ser Ser 
145                 150                 155                 160 


Cys Ser Asp Pro Ser Pro Pro Gly Glu Ser Pro Ser Leu Asp Ser Leu 
                165                 170                 175     


Glu Ser Phe Ser Asn Leu His Ser Phe Pro Ser Ser Cys Glu Phe Asn 
            180                 185                 190         


Ser Glu Glu Gly Ala Glu Asn Arg Val Pro Glu Glu Glu Glu Gly Ala 
        195                 200                 205             


Ala Val Leu Pro Gly Ala Val Pro Leu Cys Lys Glu Glu Glu Gly Glu 
    210                 215                 220                 


Glu Thr Ala Gln Val Leu Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln 
225                 230                 235                 240 


Ser Val Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro 
                245                 250                 255     


Ile Ile Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu 
            260                 265                 270         


Asn Val Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu 
        275                 280                 285             


Ile Ile Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu 
    290                 295                 300                 


Asp Ala Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu 
305                 310                 315                 320 


Gln Asn Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly 
                325                 330                 335     


Leu Asp Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr 
            340                 345                 350         


Pro Glu Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly 
        355                 360                 365             


Trp Leu Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn 
    370                 375                 380                 


Cys Ser Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser 
385                 390                 395                 400 


Asp Asn Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu 
                405                 410                 415     


Asn Asn Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr 
            420                 425                 430         


Ser Thr Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His 
        435                 440                 445             


Phe Ser Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr 
    450                 455                 460                 


Asp Gln Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His 
465                 470                 475                 480 


Asn Val Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg 
                485                 490                 495     


Pro Pro Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile 
            500                 505                 510         


Asp Gln Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser 
        515                 520                 525             


Gln Glu Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu 
    530                 535                 540                 


Leu Ala Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr 
545                 550                 555                 560 


Tyr Gln Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr 
                565                 570                 575     


Gln Ala Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg 
            580                 585                 590         


Gln Ser Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp 
        595                 600                 605             


Lys Glu Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
    610                 615                 620     


<210> 95
<211> 757
<212> PRT
<213> Homo sapiens

<400> 95
Met Asp Ser Leu Phe Val Glu Glu Val Ala Ala Ser Leu Val Arg Glu 
1               5                   10                  15      


Phe Leu Ser Arg Lys Gly Leu Lys Lys Thr Cys Val Thr Met Asp Gln 
            20                  25                  30          


Glu Arg Pro Arg Ser Asp Leu Ser Ile Asn Asn Arg Asn Asp Leu Arg 
        35                  40                  45              


Lys Val Leu His Leu Glu Phe Leu Tyr Lys Glu Asn Lys Ala Lys Glu 
    50                  55                  60                  


Asn Pro Leu Lys Thr Ser Leu Glu Leu Ile Thr Arg Tyr Phe Leu Asp 
65                  70                  75                  80  


His Phe Gly Asn Thr Ala Asn Asn Phe Thr Gln Asp Thr Pro Ile Pro 
                85                  90                  95      


Ala Leu Ser Val Pro Lys Lys Asn Asn Lys Val Pro Ser Arg Cys Ser 
            100                 105                 110         


Glu Thr Thr Leu Val Asn Ile Tyr Asp Leu Ser Asp Glu Asp Ala Gly 
        115                 120                 125             


Trp Arg Thr Ser Leu Ser Glu Thr Ser Lys Ala Arg His Asp Asn Leu 
    130                 135                 140                 


Asp Gly Asp Val Leu Gly Asn Phe Val Ser Ser Lys Arg Pro Pro His 
145                 150                 155                 160 


Lys Ser Lys Pro Met Gln Thr Val Pro Gly Glu Thr Pro Val Leu Thr 
                165                 170                 175     


Ser Ala Trp Glu Lys Ile Asp Lys Leu His Ser Glu Pro Ser Leu Asp 
            180                 185                 190         


Val Lys Arg Met Gly Glu Asn Ser Arg Pro Lys Ser Gly Leu Ile Val 
        195                 200                 205             


Arg Gly Met Met Ser Gly Pro Ile Ala Ser Ser Pro Gln Asp Ser Phe 
    210                 215                 220                 


His Arg His Tyr Leu Arg Arg Ser Ser Pro Ser Ser Ser Ser Thr Gln 
225                 230                 235                 240 


Pro Gln Glu Glu Ser Arg Lys Val Pro Glu Leu Phe Val Cys Thr Gln 
                245                 250                 255     


Gln Asp Ile Leu Ala Ser Ser Asn Ser Ser Pro Ser Arg Thr Ser Leu 
            260                 265                 270         


Gly Gln Leu Ser Glu Leu Thr Val Glu Arg Gln Lys Thr Thr Ala Ser 
        275                 280                 285             


Ser Pro Pro His Leu Pro Ser Lys Arg Leu Pro Pro Trp Asp Arg Ala 
    290                 295                 300                 


Arg Pro Arg Asp Pro Ser Glu Asp Thr Pro Ala Val Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Thr Asp Arg Met Pro Leu Lys Leu Tyr Leu Pro Gly Gly Asn Ser 
                325                 330                 335     


Arg Met Thr Gln Glu Arg Leu Glu Arg Ala Phe Lys Arg Gln Gly Ser 
            340                 345                 350         


Gln Pro Ala Pro Val Arg Lys Asn Gln Leu Leu Pro Ser Asp Lys Val 
        355                 360                 365             


Asp Gly Glu Leu Gly Ala Leu Arg Leu Glu Asp Val Glu Asp Glu Leu 
    370                 375                 380                 


Ile Arg Glu Glu Val Ile Leu Ser Pro Val Pro Ser Val Leu Lys Leu 
385                 390                 395                 400 


Gln Thr Ala Ser Lys Pro Ile Asp Leu Ser Val Ala Lys Glu Ile Lys 
                405                 410                 415     


Thr Leu Leu Phe Gly Ser Ser Phe Cys Cys Phe Asn Glu Glu Trp Lys 
            420                 425                 430         


Leu Gln Ser Phe Ser Phe Ser Asn Thr Ala Ser Leu Lys Tyr Gly Ile 
        435                 440                 445             


Val Gln Asn Lys Gly Gly Pro Cys Gly Val Leu Ala Ala Val Gln Gly 
    450                 455                 460                 


Cys Val Leu Gln Lys Leu Leu Phe Glu Gly Asp Ser Lys Ala Asp Cys 
465                 470                 475                 480 


Ala Gln Gly Leu Gln Pro Ser Asp Ala His Arg Thr Arg Cys Leu Val 
                485                 490                 495     


Leu Ala Leu Ala Asp Ile Val Trp Arg Ala Gly Gly Arg Glu Arg Ala 
            500                 505                 510         


Val Val Ala Leu Ala Ser Arg Thr Gln Gln Phe Ser Pro Thr Gly Lys 
        515                 520                 525             


Tyr Lys Ala Asp Gly Val Leu Glu Thr Leu Thr Leu His Ser Leu Thr 
    530                 535                 540                 


Cys Tyr Glu Asp Leu Val Thr Phe Leu Gln Gln Ser Ile His Gln Phe 
545                 550                 555                 560 


Glu Val Gly Pro Tyr Gly Cys Ile Leu Leu Thr Leu Ser Ala Ile Leu 
                565                 570                 575     


Ser Arg Ser Thr Glu Leu Ile Arg Gln Asp Phe Asp Val Pro Thr Ser 
            580                 585                 590         


His Leu Ile Gly Ala His Gly Tyr Cys Thr Gln Glu Leu Val Asn Leu 
        595                 600                 605             


Leu Leu Thr Gly Lys Ala Val Ser Asn Val Phe Asn Asp Val Val Glu 
    610                 615                 620                 


Leu Asp Ser Gly Asp Gly Asn Ile Thr Leu Leu Arg Gly Ile Ala Ala 
625                 630                 635                 640 


Arg Ser Asp Ile Gly Phe Leu Ser Leu Phe Glu His Tyr Asn Met Cys 
                645                 650                 655     


Gln Val Gly Cys Phe Leu Lys Thr Pro Arg Phe Pro Ile Trp Val Val 
            660                 665                 670         


Cys Ser Glu Ser His Phe Ser Ile Leu Phe Ser Leu Gln Pro Gly Leu 
        675                 680                 685             


Leu Arg Asp Trp Arg Thr Glu Arg Leu Phe Asp Leu Tyr Tyr Tyr Asp 
    690                 695                 700                 


Gly Leu Ala Asn Gln Gln Glu Gln Ile Arg Leu Thr Ile Asp Thr Thr 
705                 710                 715                 720 


Gln Thr Ile Ser Glu Asp Thr Asp Asn Asp Leu Val Pro Pro Leu Glu 
                725                 730                 735     


Leu Cys Ile Arg Thr Lys Trp Lys Gly Ala Ser Val Asn Trp Asn Gly 
            740                 745                 750         


Ser Asp Pro Ile Leu 
        755         


<210> 96
<211> 424
<212> PRT
<213> Homo sapiens

<400> 96
Met Ser Asp His Gly Asp Val Ser Leu Pro Pro Glu Asp Arg Val Arg 
1               5                   10                  15      


Ala Leu Ser Gln Leu Gly Ser Ala Val Glu Val Asn Glu Asp Ile Pro 
            20                  25                  30          


Pro Arg Arg Tyr Phe Arg Ser Gly Val Glu Ile Ile Arg Met Ala Ser 
        35                  40                  45              


Ile Tyr Ser Glu Glu Gly Asn Ile Glu His Ala Phe Ile Leu Tyr Asn 
    50                  55                  60                  


Lys Tyr Ile Thr Leu Phe Ile Glu Lys Leu Pro Lys His Arg Asp Tyr 
65                  70                  75                  80  


Lys Ser Ala Val Ile Pro Glu Lys Lys Asp Thr Val Lys Lys Leu Lys 
                85                  90                  95      


Glu Ile Ala Phe Pro Lys Ala Glu Glu Leu Lys Ala Glu Leu Leu Lys 
            100                 105                 110         


Arg Tyr Thr Lys Glu Tyr Thr Glu Tyr Asn Glu Glu Lys Lys Lys Glu 
        115                 120                 125             


Ala Glu Glu Leu Ala Arg Asn Met Ala Ile Gln Gln Glu Leu Glu Lys 
    130                 135                 140                 


Glu Lys Gln Arg Val Ala Gln Gln Lys Gln Gln Gln Leu Glu Gln Glu 
145                 150                 155                 160 


Gln Phe His Ala Phe Glu Glu Met Ile Arg Asn Gln Glu Leu Glu Lys 
                165                 170                 175     


Glu Arg Leu Lys Ile Val Gln Glu Phe Gly Lys Val Asp Pro Gly Leu 
            180                 185                 190         


Gly Gly Pro Leu Val Pro Asp Leu Glu Lys Pro Ser Leu Asp Val Phe 
        195                 200                 205             


Pro Thr Leu Thr Val Ser Ser Ile Gln Pro Ser Asp Cys His Thr Thr 
    210                 215                 220                 


Val Arg Pro Ala Lys Pro Pro Val Val Asp Arg Ser Leu Lys Pro Gly 
225                 230                 235                 240 


Ala Leu Ser Asn Ser Glu Ser Ile Pro Thr Ile Asp Gly Leu Arg His 
                245                 250                 255     


Val Val Val Pro Gly Arg Leu Cys Pro Gln Phe Leu Gln Leu Ala Ser 
            260                 265                 270         


Ala Asn Thr Ala Arg Gly Val Glu Thr Cys Gly Ile Leu Cys Gly Lys 
        275                 280                 285             


Leu Met Arg Asn Glu Phe Thr Ile Thr His Val Leu Ile Pro Lys Gln 
    290                 295                 300                 


Ser Ala Gly Ser Asp Tyr Cys Asn Thr Glu Asn Glu Glu Glu Leu Phe 
305                 310                 315                 320 


Leu Ile Gln Asp Gln Gln Gly Leu Ile Thr Leu Gly Trp Ile His Thr 
                325                 330                 335     


His Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His 
            340                 345                 350         


Cys Ser Tyr Gln Met Met Leu Pro Glu Ser Val Ala Ile Val Cys Ser 
        355                 360                 365             


Pro Lys Phe Gln Glu Thr Gly Phe Phe Lys Leu Thr Asp His Gly Leu 
    370                 375                 380                 


Glu Glu Ile Ser Ser Cys Arg Gln Lys Gly Phe His Pro His Ser Lys 
385                 390                 395                 400 


Asp Pro Pro Leu Phe Cys Ser Cys Ser His Val Thr Val Val Asp Arg 
                405                 410                 415     


Ala Val Thr Ile Thr Asp Leu Arg 
            420                 


<210> 97
<211> 471
<212> PRT
<213> Homo sapiens

<400> 97
Met Ala Ala Pro Glu Pro Leu Ser Pro Ala Gly Gly Ala Gly Glu Glu 
1               5                   10                  15      


Ala Pro Glu Glu Asp Glu Asp Glu Ala Glu Ala Glu Asp Pro Glu Arg 
            20                  25                  30          


Pro Asn Ala Gly Ala Gly Gly Gly Arg Ser Gly Gly Gly Gly Ser Ser 
        35                  40                  45              


Val Ser Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Cys Gly 
    50                  55                  60                  


Gly Pro Gly Gly Ala Leu Thr Arg Arg Ala Val Thr Leu Arg Val Leu 
65                  70                  75                  80  


Leu Lys Asp Ala Leu Leu Glu Pro Gly Ala Gly Val Leu Ser Ile Tyr 
                85                  90                  95      


Tyr Leu Gly Lys Lys Phe Leu Gly Asp Leu Gln Pro Asp Gly Arg Ile 
            100                 105                 110         


Met Trp Gln Glu Thr Gly Gln Thr Phe Asn Ser Pro Ser Ala Trp Ala 
        115                 120                 125             


Thr His Cys Lys Lys Leu Val Asn Pro Ala Lys Lys Ser Gly Cys Gly 
    130                 135                 140                 


Trp Ala Ser Val Lys Tyr Lys Gly Gln Lys Leu Asp Lys Tyr Lys Ala 
145                 150                 155                 160 


Thr Trp Leu Arg Leu His Gln Leu His Thr Pro Ala Thr Ala Ala Asp 
                165                 170                 175     


Glu Ser Pro Ala Ser Glu Gly Glu Glu Glu Glu Leu Leu Met Glu Glu 
            180                 185                 190         


Glu Glu Glu Asp Val Leu Ala Gly Val Ser Ala Glu Asp Lys Ser Arg 
        195                 200                 205             


Arg Pro Leu Gly Lys Ser Pro Ser Glu Pro Ala His Pro Glu Ala Thr 
    210                 215                 220                 


Thr Pro Gly Lys Arg Val Asp Ser Lys Ile Arg Val Pro Val Arg Tyr 
225                 230                 235                 240 


Cys Met Leu Gly Ser Arg Asp Leu Ala Arg Asn Pro His Thr Leu Val 
                245                 250                 255     


Glu Val Thr Ser Phe Ala Ala Ile Asn Lys Phe Gln Pro Phe Asn Val 
            260                 265                 270         


Ala Val Ser Ser Asn Val Leu Phe Leu Leu Asp Phe His Ser His Leu 
        275                 280                 285             


Thr Arg Ser Glu Val Val Gly Tyr Leu Gly Gly Arg Trp Asp Val Asn 
    290                 295                 300                 


Ser Gln Met Leu Thr Val Leu Arg Ala Phe Pro Cys Arg Ser Arg Leu 
305                 310                 315                 320 


Gly Asp Ala Glu Thr Ala Ala Ala Ile Glu Glu Glu Ile Tyr Gln Ser 
                325                 330                 335     


Leu Phe Leu Arg Gly Leu Ser Leu Val Gly Trp Tyr His Ser His Pro 
            340                 345                 350         


His Ser Pro Ala Leu Pro Ser Leu Gln Asp Ile Asp Ala Gln Met Asp 
        355                 360                 365             


Tyr Gln Leu Arg Leu Gln Gly Ser Ser Asn Gly Phe Gln Pro Cys Leu 
    370                 375                 380                 


Ala Leu Leu Cys Ser Pro Tyr Tyr Ser Gly Asn Pro Gly Pro Glu Ser 
385                 390                 395                 400 


Lys Ile Ser Pro Phe Trp Val Met Pro Pro Pro Glu Met Leu Leu Val 
                405                 410                 415     


Glu Phe Tyr Lys Gly Ser Pro Asp Leu Val Arg Leu Gln Glu Pro Trp 
            420                 425                 430         


Ser Gln Glu His Thr Tyr Leu Asp Lys Leu Lys Ile Ser Leu Ala Ser 
        435                 440                 445             


Arg Thr Pro Lys Asp Gln Ser Leu Cys His Val Leu Glu Gln Val Cys 
    450                 455                 460                 


Gly Val Leu Lys Gln Gly Ser 
465                 470     


<210> 98
<211> 208
<212> PRT
<213> Homo sapiens

<400> 98
Met Gly Glu Val Glu Ile Ser Ala Leu Ala Tyr Val Lys Met Cys Leu 
1               5                   10                  15      


His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala 
            20                  25                  30          


Pro Ala Pro Arg Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro 
        35                  40                  45              


Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu 
    50                  55                  60                  


Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly 
65                  70                  75                  80  


Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Pro Gly Pro Leu 
                85                  90                  95      


Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu Phe Phe Pro Asp Ala Val 
            100                 105                 110         


Leu Ile Met Leu Asp Asn Gln Lys Leu Val Pro Gln Pro Arg Val Pro 
        115                 120                 125             


Pro Val Ile Val Leu Glu Asn Gln Gly Leu Arg Trp Val Pro Lys Asp 
    130                 135                 140                 


Lys Asn Leu Val Met Trp Arg Asp Trp Glu Glu Ser Arg Gln Met Val 
145                 150                 155                 160 


Gly Ala Leu Leu Glu Asp Arg Ala His Gln His Leu Val Asp Phe Asp 
                165                 170                 175     


Cys His Leu Asp Asp Ile Arg Gln Asp Trp Thr Asn Gln Arg Leu Asn 
            180                 185                 190         


Thr Gln Ile Thr Gln Trp Val Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200                 205             


<210> 99
<211> 310
<212> PRT
<213> Homo sapiens

<400> 99
Met Asp Arg Leu Leu Arg Leu Gly Gly Gly Met Pro Gly Leu Gly Gln 
1               5                   10                  15      


Gly Pro Pro Thr Asp Ala Pro Ala Val Asp Thr Ala Glu Gln Val Tyr 
            20                  25                  30          


Ile Ser Ser Leu Ala Leu Leu Lys Met Leu Lys His Gly Arg Ala Gly 
        35                  40                  45              


Val Pro Met Glu Val Met Gly Leu Met Leu Gly Glu Phe Val Asp Asp 
    50                  55                  60                  


Tyr Thr Val Arg Val Ile Asp Val Phe Ala Met Pro Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Val Ser Val Glu Ala Val Asp Pro Val Phe Gln Ala Lys Met Leu 
                85                  90                  95      


Asp Met Leu Lys Gln Thr Gly Arg Pro Glu Met Val Val Gly Trp Tyr 
            100                 105                 110         


His Ser His Pro Gly Phe Gly Cys Trp Leu Ser Gly Val Asp Ile Asn 
        115                 120                 125             


Thr Gln Gln Ser Phe Glu Ala Leu Ser Glu Arg Ala Val Ala Val Val 
    130                 135                 140                 


Val Asp Pro Ile Gln Ser Val Lys Gly Lys Val Val Ile Asp Ala Phe 
145                 150                 155                 160 


Arg Leu Ile Asn Ala Asn Met Met Val Leu Gly His Glu Pro Arg Gln 
                165                 170                 175     


Thr Thr Ser Asn Leu Gly His Leu Asn Lys Pro Ser Ile Gln Ala Leu 
            180                 185                 190         


Ile His Gly Leu Asn Arg His Tyr Tyr Ser Ile Thr Ile Asn Tyr Arg 
        195                 200                 205             


Lys Asn Glu Leu Glu Gln Lys Met Leu Leu Asn Leu His Lys Lys Ser 
    210                 215                 220                 


Trp Met Glu Gly Leu Thr Leu Gln Asp Tyr Ser Glu His Cys Lys His 
225                 230                 235                 240 


Asn Glu Ser Val Val Lys Glu Met Leu Glu Leu Ala Lys Asn Tyr Asn 
                245                 250                 255     


Lys Ala Val Glu Glu Glu Asp Lys Met Thr Pro Glu Gln Leu Ala Ile 
            260                 265                 270         


Lys Asn Val Gly Lys Gln Asp Pro Lys Arg His Leu Glu Glu His Val 
        275                 280                 285             


Asp Val Leu Met Thr Ser Asn Ile Val Gln Cys Leu Ala Ala Met Leu 
    290                 295                 300                 


Asp Thr Val Val Phe Lys 
305                 310 


<210> 100
<211> 828
<212> PRT
<213> Homo sapiens

<400> 100
Met Ala Ala Glu Glu Ala Asp Val Asp Ile Glu Gly Asp Val Val Ala 
1               5                   10                  15      


Ala Ala Gly Ala Gln Pro Gly Ser Gly Glu Asn Thr Ala Ser Val Leu 
            20                  25                  30          


Gln Lys Asp His Tyr Leu Asp Ser Ser Trp Arg Thr Glu Asn Gly Leu 
        35                  40                  45              


Ile Pro Trp Thr Leu Asp Asn Thr Ile Ser Glu Glu Asn Arg Ala Val 
    50                  55                  60                  


Ile Glu Lys Met Leu Leu Glu Glu Glu Tyr Tyr Leu Ser Lys Lys Ser 
65                  70                  75                  80  


Gln Pro Glu Lys Val Trp Leu Asp Gln Lys Glu Asp Asp Lys Lys Tyr 
                85                  90                  95      


Met Lys Ser Leu Gln Lys Thr Ala Lys Ile Met Val His Ser Pro Thr 
            100                 105                 110         


Lys Pro Ala Ser Tyr Ser Val Lys Trp Thr Ile Glu Glu Lys Glu Leu 
        115                 120                 125             


Phe Glu Gln Gly Leu Ala Lys Phe Gly Arg Arg Trp Thr Lys Ile Ser 
    130                 135                 140                 


Lys Leu Ile Gly Ser Arg Thr Val Leu Gln Val Lys Ser Tyr Ala Arg 
145                 150                 155                 160 


Gln Tyr Phe Lys Asn Lys Val Lys Cys Gly Leu Asp Lys Glu Thr Pro 
                165                 170                 175     


Asn Gln Lys Thr Gly His Asn Leu Gln Val Lys Asn Glu Asp Lys Gly 
            180                 185                 190         


Thr Lys Ala Trp Thr Pro Ser Cys Leu Arg Gly Arg Ala Asp Pro Asn 
        195                 200                 205             


Leu Asn Ala Val Lys Ile Glu Lys Leu Ser Asp Asp Glu Glu Val Asp 
    210                 215                 220                 


Ile Thr Asp Glu Val Asp Glu Leu Ser Ser Gln Thr Pro Gln Lys Asn 
225                 230                 235                 240 


Ser Ser Ser Asp Leu Leu Leu Asp Phe Pro Asn Ser Lys Met His Glu 
                245                 250                 255     


Thr Asn Gln Gly Glu Phe Ile Thr Ser Asp Ser Gln Glu Ala Leu Phe 
            260                 265                 270         


Ser Lys Ser Ser Arg Gly Cys Leu Gln Asn Glu Lys Gln Asp Glu Thr 
        275                 280                 285             


Leu Ser Ser Ser Glu Ile Thr Leu Trp Thr Glu Lys Gln Ser Asn Gly 
    290                 295                 300                 


Asp Lys Lys Ser Ile Glu Leu Asn Asp Gln Lys Phe Asn Glu Leu Ile 
305                 310                 315                 320 


Lys Asn Cys Asn Lys His Asp Gly Arg Gly Ile Ile Val Asp Ala Arg 
                325                 330                 335     


Gln Leu Pro Ser Pro Glu Pro Cys Glu Ile Gln Lys Asn Leu Asn Asp 
            340                 345                 350         


Asn Glu Met Leu Phe His Ser Cys Gln Met Val Glu Glu Ser His Glu 
        355                 360                 365             


Glu Glu Glu Leu Lys Pro Pro Glu Gln Glu Ile Glu Ile Asp Arg Asn 
    370                 375                 380                 


Ile Ile Gln Glu Glu Glu Lys Gln Ala Ile Pro Glu Phe Phe Glu Gly 
385                 390                 395                 400 


Arg Gln Ala Lys Thr Pro Glu Arg Tyr Leu Lys Ile Arg Asn Tyr Ile 
                405                 410                 415     


Leu Asp Gln Trp Glu Ile Cys Lys Pro Lys Tyr Leu Asn Lys Thr Ser 
            420                 425                 430         


Val Arg Pro Gly Leu Lys Asn Cys Gly Asp Val Asn Cys Ile Gly Arg 
        435                 440                 445             


Ile His Thr Tyr Leu Glu Leu Ile Gly Ala Ile Asn Phe Gly Cys Glu 
    450                 455                 460                 


Gln Ala Val Tyr Asn Arg Pro Gln Thr Val Asp Lys Val Arg Ile Arg 
465                 470                 475                 480 


Asp Arg Lys Asp Ala Val Glu Ala Tyr Gln Leu Ala Gln Arg Leu Gln 
                485                 490                 495     


Ser Met Arg Thr Arg Arg Arg Arg Val Arg Asp Pro Trp Gly Asn Trp 
            500                 505                 510         


Cys Asp Ala Lys Asp Leu Glu Gly Gln Thr Phe Glu His Leu Ser Ala 
        515                 520                 525             


Glu Glu Leu Ala Lys Arg Arg Glu Glu Glu Lys Gly Arg Pro Val Lys 
    530                 535                 540                 


Ser Leu Lys Val Pro Arg Pro Thr Lys Ser Ser Phe Asp Pro Phe Gln 
545                 550                 555                 560 


Leu Ile Pro Cys Asn Phe Phe Ser Glu Glu Lys Gln Glu Pro Phe Gln 
                565                 570                 575     


Val Lys Val Ala Ser Glu Ala Leu Leu Ile Met Asp Leu His Ala His 
            580                 585                 590         


Val Ser Met Ala Glu Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser Glu 
        595                 600                 605             


Val Asp Lys Val Val Glu Val Cys Ala Ala Glu Pro Cys Asn Ser Leu 
    610                 615                 620                 


Ser Thr Gly Leu Gln Cys Glu Met Asp Pro Val Ser Gln Thr Gln Ala 
625                 630                 635                 640 


Ser Glu Thr Leu Ala Val Arg Gly Phe Ser Val Ile Gly Trp Tyr His 
                645                 650                 655     


Ser His Pro Ala Phe Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp Thr 
            660                 665                 670         


Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe Ile 
        675                 680                 685             


Gly Met Ile Val Ser Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr Ser 
    690                 695                 700                 


Gln Ile Thr Cys Leu Val Ile Ser Glu Glu Ile Ser Pro Asp Gly Ser 
705                 710                 715                 720 


Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln Gln Met Leu Glu Glu Pro 
                725                 730                 735     


Gln Trp Gly Leu Val Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys Tyr 
            740                 745                 750         


Arg Leu Ser His Ser Ser Val Pro Met Asp Lys Ile Phe Arg Arg Asp 
        755                 760                 765             


Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu Glu Cys Met Arg Lys Thr 
    770                 775                 780                 


Leu Ser Lys Val Thr Asn Cys Phe Met Ala Glu Glu Phe Leu Thr Glu 
785                 790                 795                 800 


Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys Ser Asn Gln Glu Asn Gly 
                805                 810                 815     


Val Thr Glu Glu Asn Cys Thr Lys Glu Leu Leu Met 
            820                 825             


<210> 101
<211> 415
<212> PRT
<213> Homo sapiens

<400> 101
Met Ala Ala Ser Ile Ser Gly Tyr Thr Phe Ser Ala Val Cys Phe His 
1               5                   10                  15      


Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe Leu Leu Gly Glu Val 
            20                  25                  30          


Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser Gln Ile Ser Asn Thr 
        35                  40                  45              


Glu Phe Leu Gln Val Ile Glu Ile His Asn His Gln Pro Cys Ser Lys 
    50                  55                  60                  


Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val Asn Glu Glu Ser Leu 
65                  70                  75                  80  


Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val Ile Gly Trp Tyr Arg 
                85                  90                  95      


Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr Arg Glu Gln Val Leu 
            100                 105                 110         


His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro Asp Leu Val Phe Leu 
        115                 120                 125             


Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser Thr His Ala Leu Glu 
    130                 135                 140                 


Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn Gln Arg Ile Ser Leu 
145                 150                 155                 160 


Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln Glu Tyr Lys Val Ser 
                165                 170                 175     


Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys Val Ile Lys Glu His 
            180                 185                 190         


Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met Lys Asp Ile Arg Ala 
        195                 200                 205             


Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys Val Gln Ala Val Cys 
    210                 215                 220                 


Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu Ser Cys Gln Ala Glu 
225                 230                 235                 240 


Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg Lys Asn Glu Lys Glu 
                245                 250                 255     


Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser Arg Gln Met Pro Ser 
            260                 265                 270         


Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met Pro Ser Ser Gly Phe 
        275                 280                 285             


Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala Glu Ala Ser Asp Pro 
    290                 295                 300                 


Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn Gln Glu Ser Thr Leu 
305                 310                 315                 320 


Ser His Ser Arg Met Glu Arg Ser Val Phe Met Pro Arg Pro Gln Ala 
                325                 330                 335     


Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala Gly Leu Lys Tyr Pro 
            340                 345                 350         


Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg Ala Ala Gly Asp Ser 
        355                 360                 365             


Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn Leu Ile Asp Pro Thr 
    370                 375                 380                 


Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys Asp Ser Arg Pro Met 
385                 390                 395                 400 


Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln Thr Ser Gln Ile 
                405                 410                 415 


<210> 102
<211> 2335
<212> PRT
<213> Homo sapiens

<400> 102
Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210> 103
<211> 608
<212> PRT
<213> Homo sapiens

<400> 103
Met Ala Glu Ser Ile Ile Ile Arg Val Gln Ser Pro Asp Gly Val Lys 
1               5                   10                  15      


Arg Ile Thr Ala Thr Lys Arg Glu Thr Ala Ala Thr Phe Leu Lys Lys 
            20                  25                  30          


Val Ala Lys Glu Phe Gly Phe Gln Asn Asn Gly Phe Ser Val Tyr Ile 
        35                  40                  45              


Asn Arg Asn Lys Thr Gly Glu Ile Thr Ala Ser Ser Asn Lys Ser Leu 
    50                  55                  60                  


Asn Leu Leu Lys Ile Lys His Gly Asp Leu Leu Phe Leu Phe Pro Ser 
65                  70                  75                  80  


Ser Leu Ala Gly Pro Ser Ser Glu Met Glu Thr Ser Val Pro Pro Gly 
                85                  90                  95      


Phe Lys Val Phe Gly Ala Pro Asn Val Val Glu Asp Glu Ile Asp Gln 
            100                 105                 110         


Tyr Leu Ser Lys Gln Asp Gly Lys Ile Tyr Arg Ser Arg Asp Pro Gln 
        115                 120                 125             


Leu Cys Arg His Gly Pro Leu Gly Lys Cys Val His Cys Val Pro Leu 
    130                 135                 140                 


Glu Pro Phe Asp Glu Asp Tyr Leu Asn His Leu Glu Pro Pro Val Lys 
145                 150                 155                 160 


His Met Ser Phe His Ala Tyr Ile Arg Lys Leu Thr Gly Gly Ala Asp 
                165                 170                 175     


Lys Gly Lys Phe Val Ala Leu Glu Asn Ile Ser Cys Lys Ile Lys Ser 
            180                 185                 190         


Gly Cys Glu Gly His Leu Pro Trp Pro Asn Gly Ile Cys Thr Lys Cys 
        195                 200                 205             


Gln Pro Ser Ala Ile Thr Leu Asn Arg Gln Lys Tyr Arg His Val Asp 
    210                 215                 220                 


Asn Ile Met Phe Glu Asn His Thr Val Ala Asp Arg Phe Leu Asp Phe 
225                 230                 235                 240 


Trp Arg Lys Thr Gly Asn Gln His Phe Gly Tyr Leu Tyr Gly Arg Tyr 
                245                 250                 255     


Thr Glu His Lys Asp Ile Pro Leu Gly Ile Arg Ala Glu Val Ala Ala 
            260                 265                 270         


Ile Tyr Glu Pro Pro Gln Ile Gly Thr Gln Asn Ser Leu Glu Leu Leu 
        275                 280                 285             


Glu Asp Pro Lys Ala Glu Val Val Asp Glu Ile Ala Ala Lys Leu Gly 
    290                 295                 300                 


Leu Arg Lys Val Gly Trp Ile Phe Thr Asp Leu Val Ser Glu Asp Thr 
305                 310                 315                 320 


Arg Lys Gly Thr Val Arg Tyr Ser Arg Asn Lys Asp Thr Tyr Phe Leu 
                325                 330                 335     


Ser Ser Glu Glu Cys Ile Thr Ala Gly Asp Phe Gln Asn Lys His Pro 
            340                 345                 350         


Asn Met Cys Arg Leu Ser Pro Asp Gly His Phe Gly Ser Lys Phe Val 
        355                 360                 365             


Thr Ala Val Ala Thr Gly Gly Pro Asp Asn Gln Val His Phe Glu Gly 
    370                 375                 380                 


Tyr Gln Val Ser Asn Gln Cys Met Ala Leu Val Arg Asp Glu Cys Leu 
385                 390                 395                 400 


Leu Pro Cys Lys Asp Ala Pro Glu Leu Gly Tyr Ala Lys Glu Ser Ser 
                405                 410                 415     


Ser Glu Gln Tyr Val Pro Asp Val Phe Tyr Lys Asp Val Asp Lys Phe 
            420                 425                 430         


Gly Asn Glu Ile Thr Gln Leu Ala Arg Pro Leu Pro Val Glu Tyr Leu 
        435                 440                 445             


Ile Ile Asp Ile Thr Thr Thr Phe Pro Lys Asp Pro Val Tyr Thr Phe 
    450                 455                 460                 


Ser Ile Ser Gln Asn Pro Phe Pro Ile Glu Asn Arg Asp Val Leu Gly 
465                 470                 475                 480 


Glu Thr Gln Asp Phe His Ser Leu Ala Thr Tyr Leu Ser Gln Asn Thr 
                485                 490                 495     


Ser Ser Val Phe Leu Asp Thr Ile Ser Asp Phe His Leu Leu Leu Phe 
            500                 505                 510         


Leu Val Thr Asn Glu Val Met Pro Leu Gln Asp Ser Ile Ser Leu Leu 
        515                 520                 525             


Leu Glu Ala Val Arg Thr Arg Asn Glu Glu Leu Ala Gln Thr Trp Lys 
    530                 535                 540                 


Arg Ser Glu Gln Trp Ala Thr Ile Glu Gln Leu Cys Ser Thr Val Gly 
545                 550                 555                 560 


Gly Gln Leu Pro Gly Leu His Glu Tyr Gly Ala Val Gly Gly Ser Thr 
                565                 570                 575     


His Thr Ala Thr Ala Ala Met Trp Ala Cys Gln His Cys Thr Phe Met 
            580                 585                 590         


Asn Gln Pro Gly Thr Gly His Cys Glu Met Cys Ser Leu Pro Arg Thr 
        595                 600                 605             


<210> 104
<211> 210
<212> PRT
<213> Homo sapiens

<400> 104
Met Pro Gly Val Lys Leu Thr Thr Gln Ala Tyr Cys Lys Met Val Leu 
1               5                   10                  15      


His Gly Ala Lys Tyr Pro His Cys Ala Val Asn Gly Leu Leu Val Ala 
            20                  25                  30          


Glu Lys Gln Lys Pro Arg Lys Glu His Leu Pro Leu Gly Gly Pro Gly 
        35                  40                  45              


Ala His His Thr Leu Phe Val Asp Cys Ile Pro Leu Phe His Gly Thr 
    50                  55                  60                  


Leu Ala Leu Ala Pro Met Leu Glu Val Ala Leu Thr Leu Ile Asp Ser 
65                  70                  75                  80  


Trp Cys Lys Asp His Ser Tyr Val Ile Ala Gly Tyr Tyr Gln Ala Asn 
                85                  90                  95      


Glu Arg Val Lys Asp Ala Ser Pro Asn Gln Val Ala Glu Lys Val Ala 
            100                 105                 110         


Ser Arg Ile Ala Glu Gly Phe Ser Asp Thr Ala Leu Ile Met Val Asp 
        115                 120                 125             


Asn Thr Lys Phe Thr Met Asp Cys Val Ala Pro Thr Ile His Val Tyr 
    130                 135                 140                 


Glu His His Glu Asn Arg Trp Arg Cys Arg Asp Pro His His Asp Tyr 
145                 150                 155                 160 


Cys Glu Asp Trp Pro Glu Ala Gln Arg Ile Ser Ala Ser Leu Leu Asp 
                165                 170                 175     


Ser Arg Ser Tyr Glu Thr Leu Val Asp Phe Asp Asn His Leu Asp Asp 
            180                 185                 190         


Ile Arg Asn Asp Trp Thr Asn Pro Glu Ile Asn Lys Ala Val Leu His 
        195                 200                 205             


Leu Cys 
    210 


<210> 105
<211> 409
<212> PRT
<213> Homo sapiens

<400> 105
Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Glu Gly Phe 
            20                  25                  30          


Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn Ser Ile Thr Asp Ser 
        35                  40                  45              


Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile Asp Ile Gln Lys Tyr 
    50                  55                  60                  


Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn Ser Ser Gly Glu Val 
65                  70                  75                  80  


Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn Val Lys Lys Asn Val 
                85                  90                  95      


Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp Gln Ile Met Thr Phe 
            100                 105                 110         


Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu His Phe Ser Asn Gln 
        115                 120                 125             


Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile Ile Thr Glu Ser Cys 
    130                 135                 140                 


Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys Pro Gln Lys Gly Leu 
145                 150                 155                 160 


Phe His Arg Val Pro Leu Val Val Ala Asn Leu Gly Met Ser Glu Gln 
                165                 170                 175     


Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met Ser Thr Gly Phe Ser 
            180                 185                 190         


Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe Glu Glu Asp Gly Ser 
        195                 200                 205             


Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr Ala Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp Ser Glu Gln Ala Val 
225                 230                 235                 240 


Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys Arg Glu Ile Glu Lys 
                245                 250                 255     


Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu Lys Asn Ile Gln Lys 
            260                 265                 270         


Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala Leu Arg Thr Phe Phe 
        275                 280                 285             


Pro Asn Ser Glu Phe Leu His Ser Cys Val Met Ser Leu Lys Asn Arg 
    290                 295                 300                 


His Val Ser Lys Ser Ser Cys Asn Tyr Asn His His Leu Asp Val Val 
305                 310                 315                 320 


Asp Asn Leu Thr Leu Met Val Glu His Thr Asp Ile Pro Glu Ala Ser 
                325                 330                 335     


Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys Ala Leu Asp Leu Asp 
            340                 345                 350         


Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu Asp Thr Gln Asp Lys 
        355                 360                 365             


Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln Asp Lys Ala Ser Lys 
    370                 375                 380                 


Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu Lys Met Lys Gly Phe 
385                 390                 395                 400 


Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
                405                 


<210> 106
<211> 436
<212> PRT
<213> Homo sapiens

<400> 106
Met Asp Gln Pro Phe Thr Val Asn Ser Leu Lys Lys Leu Ala Ala Met 
1               5                   10                  15      


Pro Asp His Thr Asp Val Ser Leu Ser Pro Glu Glu Arg Val Arg Ala 
            20                  25                  30          


Leu Ser Lys Leu Gly Cys Asn Ile Thr Ile Ser Glu Asp Ile Thr Pro 
        35                  40                  45              


Arg Arg Tyr Phe Arg Ser Gly Val Glu Met Glu Arg Met Ala Ser Val 
    50                  55                  60                  


Tyr Leu Glu Glu Gly Asn Leu Glu Asn Ala Phe Val Leu Tyr Asn Lys 
65                  70                  75                  80  


Phe Ile Thr Leu Phe Val Glu Lys Leu Pro Asn His Arg Asp Tyr Gln 
                85                  90                  95      


Gln Cys Ala Val Pro Glu Lys Gln Asp Ile Met Lys Lys Leu Lys Glu 
            100                 105                 110         


Ile Ala Phe Pro Arg Thr Asp Glu Leu Lys Asn Asp Leu Leu Lys Lys 
        115                 120                 125             


Tyr Asn Val Glu Tyr Gln Glu Tyr Leu Gln Ser Lys Asn Lys Tyr Lys 
    130                 135                 140                 


Ala Glu Ile Leu Lys Lys Leu Glu His Gln Arg Leu Ile Glu Ala Glu 
145                 150                 155                 160 


Arg Lys Arg Ile Ala Gln Met Arg Gln Gln Gln Leu Glu Ser Glu Gln 
                165                 170                 175     


Phe Leu Phe Phe Glu Asp Gln Leu Lys Lys Gln Glu Leu Ala Arg Gly 
            180                 185                 190         


Gln Met Arg Ser Gln Gln Thr Ser Gly Leu Ser Glu Gln Ile Asp Gly 
        195                 200                 205             


Ser Ala Leu Ser Cys Phe Ser Thr His Gln Asn Asn Ser Leu Leu Asn 
    210                 215                 220                 


Val Phe Ala Asp Gln Pro Asn Lys Ser Asp Ala Thr Asn Tyr Ala Ser 
225                 230                 235                 240 


His Ser Pro Pro Val Asn Arg Ala Leu Thr Pro Ala Ala Thr Leu Ser 
                245                 250                 255     


Ala Val Gln Asn Leu Val Val Glu Gly Leu Arg Cys Val Val Leu Pro 
            260                 265                 270         


Glu Asp Leu Cys His Lys Phe Leu Gln Leu Ala Glu Ser Asn Thr Val 
        275                 280                 285             


Arg Gly Ile Glu Thr Cys Gly Ile Leu Cys Gly Lys Leu Thr His Asn 
    290                 295                 300                 


Glu Phe Thr Ile Thr His Val Ile Val Pro Lys Gln Ser Ala Gly Pro 
305                 310                 315                 320 


Asp Tyr Cys Asp Met Glu Asn Val Glu Glu Leu Phe Asn Val Gln Asp 
                325                 330                 335     


Gln His Asp Leu Leu Thr Leu Gly Trp Ile His Thr His Pro Thr Gln 
            340                 345                 350         


Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His Cys Ser Tyr Gln 
        355                 360                 365             


Leu Met Leu Pro Glu Ala Ile Ala Ile Val Cys Ser Pro Lys His Lys 
    370                 375                 380                 


Asp Thr Gly Ile Phe Arg Leu Thr Asn Ala Gly Met Leu Glu Val Ser 
385                 390                 395                 400 


Ala Cys Lys Lys Lys Gly Phe His Pro His Thr Lys Glu Pro Arg Leu 
                405                 410                 415     


Phe Ser Ile Cys Lys His Val Leu Val Lys Asp Ile Lys Ile Ile Val 
            420                 425                 430         


Leu Asp Leu Arg 
        435     


<210> 107
<211> 327
<212> PRT
<213> Homo sapiens

<400> 107
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210> 108
<211> 357
<212> PRT
<213> Homo sapiens

<400> 108
Met Ala Thr Pro Ala Val Pro Val Ser Ala Pro Pro Ala Thr Pro Thr 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Pro Ala Ser Val Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ala Ala Pro Val Pro Ala Ala Ala Pro Ala Ser Ser Ser Asp 
        35                  40                  45              


Pro Ala Ala Ala Ala Ala Ala Thr Ala Ala Pro Gly Gln Thr Pro Ala 
    50                  55                  60                  


Ser Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro Ala Leu Pro Gly Pro 
65                  70                  75                  80  


Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val Val Arg Leu His Pro 
                85                  90                  95      


Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu Arg Arg Asn Glu Gly 
            100                 105                 110         


Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr Val Asp Lys His Ser 
        115                 120                 125             


Val Glu Val Thr Asn Cys Phe Ser Val Pro His Asn Glu Ser Glu Asp 
    130                 135                 140                 


Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn Met Tyr Glu Leu His 
145                 150                 155                 160 


Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly Trp Tyr Ala Thr Gly 
                165                 170                 175     


His Asp Ile Thr Glu His Ser Val Leu Ile His Glu Tyr Tyr Ser Arg 
            180                 185                 190         


Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp Thr Ser Leu Gln Asn 
        195                 200                 205             


Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr Leu Met Gly Val Pro 
    210                 215                 220                 


Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu Thr Val Lys Tyr Ala 
225                 230                 235                 240 


Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu Ile Met Lys Thr Cys 
                245                 250                 255     


Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser Asp Leu Gln Gln Val 
            260                 265                 270         


Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu Ser Thr Val Leu Gln 
        275                 280                 285             


Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser Ala Asp Asn Thr Val 
    290                 295                 300                 


Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val Pro Lys Ile Val Pro 
305                 310                 315                 320 


Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile Asn Asp Leu Leu Met 
                325                 330                 335     


Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile Ala Leu Asn Glu 
            340                 345                 350         


Lys Leu Val Asn Leu 
        355         


<210> 109
<211> 324
<212> PRT
<213> Homo sapiens

<400> 109
Met Pro Glu Leu Ala Val Gln Lys Val Val Val His Pro Leu Val Leu 
1               5                   10                  15      


Leu Ser Val Val Asp His Phe Asn Arg Ile Gly Lys Val Gly Asn Gln 
            20                  25                  30          


Lys Arg Val Val Gly Val Leu Leu Gly Ser Trp Gln Lys Lys Val Leu 
        35                  40                  45              


Asp Val Ser Asn Ser Phe Ala Val Pro Phe Asp Glu Asp Asp Lys Asp 
    50                  55                  60                  


Asp Ser Val Trp Phe Leu Asp His Asp Tyr Leu Glu Asn Met Tyr Gly 
65                  70                  75                  80  


Met Phe Lys Lys Val Asn Ala Arg Glu Arg Ile Val Gly Trp Tyr His 
                85                  90                  95      


Thr Gly Pro Lys Leu His Lys Asn Asp Ile Ala Ile Asn Glu Leu Met 
            100                 105                 110         


Lys Arg Tyr Cys Pro Asn Ser Val Leu Val Ile Ile Asp Val Lys Pro 
        115                 120                 125             


Lys Asp Leu Gly Leu Pro Thr Glu Ala Tyr Ile Ser Val Glu Glu Val 
    130                 135                 140                 


His Asp Asp Gly Thr Pro Thr Ser Lys Thr Phe Glu His Val Thr Ser 
145                 150                 155                 160 


Glu Ile Gly Ala Glu Glu Ala Glu Glu Val Gly Val Glu His Leu Leu 
                165                 170                 175     


Arg Asp Ile Lys Asp Thr Thr Val Gly Thr Leu Ser Gln Arg Ile Thr 
            180                 185                 190         


Asn Gln Val His Gly Leu Lys Gly Leu Asn Ser Lys Leu Leu Asp Ile 
        195                 200                 205             


Arg Ser Tyr Leu Glu Lys Val Ala Thr Gly Lys Leu Pro Ile Asn His 
    210                 215                 220                 


Gln Ile Ile Tyr Gln Leu Gln Asp Val Phe Asn Leu Leu Pro Asp Val 
225                 230                 235                 240 


Ser Leu Gln Glu Phe Val Lys Ala Phe Tyr Leu Lys Thr Asn Asp Gln 
                245                 250                 255     


Met Val Val Val Tyr Leu Ala Ser Leu Ile Arg Ser Val Val Ala Leu 
            260                 265                 270         


His Asn Leu Ile Asn Asn Lys Ile Ala Asn Arg Asp Ala Glu Lys Lys 
        275                 280                 285             


Glu Gly Gln Glu Lys Glu Glu Ser Lys Lys Asp Arg Lys Glu Asp Lys 
    290                 295                 300                 


Glu Lys Asp Lys Asp Lys Glu Lys Ser Asp Val Lys Lys Glu Glu Lys 
305                 310                 315                 320 


Lys Glu Lys Lys 
                


<210> 110
<211> 352
<212> PRT
<213> Homo sapiens

<400> 110
Met Ala Ser Arg Lys Glu Gly Thr Gly Ser Thr Ala Thr Ser Ser Ser 
1               5                   10                  15      


Ser Thr Ala Gly Ala Ala Gly Lys Gly Lys Gly Lys Gly Gly Ser Gly 
            20                  25                  30          


Asp Ser Ala Val Lys Gln Val Gln Ile Asp Gly Leu Val Val Leu Lys 
        35                  40                  45              


Ile Ile Lys His Tyr Gln Glu Glu Gly Gln Gly Thr Glu Val Val Gln 
    50                  55                  60                  


Gly Val Leu Leu Gly Leu Val Val Glu Asp Arg Leu Glu Ile Thr Asn 
65                  70                  75                  80  


Cys Phe Pro Phe Pro Gln His Thr Glu Asp Asp Ala Asp Phe Asp Glu 
                85                  90                  95      


Val Gln Tyr Gln Met Glu Met Met Arg Ser Leu Arg His Val Asn Ile 
            100                 105                 110         


Asp His Leu His Val Gly Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe 
        115                 120                 125             


Val Thr Arg Ala Leu Leu Asp Ser Gln Phe Ser Tyr Gln His Ala Ile 
    130                 135                 140                 


Glu Glu Ser Val Val Leu Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly 
145                 150                 155                 160 


Ser Leu Ser Leu Lys Ala Tyr Arg Leu Thr Pro Lys Leu Met Glu Val 
                165                 170                 175     


Cys Lys Glu Lys Asp Phe Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile 
            180                 185                 190         


Thr Phe Glu Tyr Met Phe Glu Glu Val Pro Ile Val Ile Lys Asn Ser 
        195                 200                 205             


His Leu Ile Asn Val Leu Met Trp Glu Leu Glu Lys Lys Ser Ala Val 
    210                 215                 220                 


Ala Asp Lys His Glu Leu Leu Ser Leu Ala Ser Ser Asn His Leu Gly 
225                 230                 235                 240 


Lys Asn Leu Gln Leu Leu Met Asp Arg Val Asp Glu Met Ser Gln Asp 
                245                 250                 255     


Ile Val Lys Tyr Asn Thr Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln 
            260                 265                 270         


Gln Lys His Gln Tyr Gln Gln Arg Arg Gln Gln Glu Asn Met Gln Arg 
        275                 280                 285             


Gln Ser Arg Gly Glu Pro Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu 
    290                 295                 300                 


Phe Lys Pro Pro Gln Pro Pro Ala Arg Met Asp Ser Leu Leu Ile Ala 
305                 310                 315                 320 


Gly Gln Ile Asn Thr Tyr Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln 
                325                 330                 335     


Asn Leu Gly Lys Leu Phe Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
            340                 345                 350         


<210> 111
<211> 334
<212> PRT
<213> Homo sapiens

<400> 111
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Thr Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Thr Lys Asp 
        35                  40                  45              


His His Tyr Phe Lys Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys 
    50                  55                  60                  


Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
65                  70                  75                  80  


Met Leu Gly Lys Val Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe 
                85                  90                  95      


Ala Leu Pro Val Glu Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala 
            100                 105                 110         


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
        115                 120                 125             


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
    130                 135                 140                 


Cys Trp Leu Ser Gly Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln 
145                 150                 155                 160 


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile 
                165                 170                 175     


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly 
            180                 185                 190         


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu 
        195                 200                 205             


Asn Lys Ile Glu Asp Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu 
    210                 215                 220                 


Glu Val Ser Tyr Phe Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu 
225                 230                 235                 240 


Leu Trp Asn Lys Tyr Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu 
                245                 250                 255     


Thr Asn Ala Asp Tyr Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys 
            260                 265                 270         


Leu Glu Gln Ser Glu Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly 
        275                 280                 285             


Leu Glu Thr His Asp Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr 
    290                 295                 300                 


Arg Asp Ser Cys Lys Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser 
305                 310                 315                 320 


Gln Val Ile Lys Asp Lys Leu Phe Asn Gln Ile Asn Ile Ser 
                325                 330                 


<210> 112
<211> 316
<212> PRT
<213> Homo sapiens

<400> 112
Met Ala Val Gln Val Val Gln Ala Val Gln Ala Val His Leu Glu Ser 
1               5                   10                  15      


Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu Ser Thr Glu Lys Glu 
            20                  25                  30          


Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn Asp Asp Thr Arg Ser 
        35                  40                  45              


Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met Arg Thr Val Ala Glu 
    50                  55                  60                  


Lys Val Asp Ala Val Arg Ile Val His Ile His Ser Val Ile Ile Leu 
65                  70                  75                  80  


Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu Ile Ser Pro Glu Gln 
                85                  90                  95      


Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu Ala Glu Leu Thr Gly 
            100                 105                 110         


Arg Pro Met Arg Val Val Gly Trp Tyr His Ser His Pro His Ile Thr 
        115                 120                 125             


Val Trp Pro Ser His Val Asp Val Arg Thr Gln Ala Met Tyr Gln Met 
    130                 135                 140                 


Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser Cys Phe Ile Glu Asp 
145                 150                 155                 160 


Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr Cys Phe Gln Ser Ile 
                165                 170                 175     


Gln Ala Gln Lys Ser Ser Glu Ser Leu His Gly Pro Arg Asp Phe Trp 
            180                 185                 190         


Ser Ser Ser Gln His Ile Ser Ile Glu Gly Gln Lys Glu Glu Glu Arg 
        195                 200                 205             


Tyr Glu Arg Ile Glu Ile Pro Ile His Ile Val Pro His Val Thr Ile 
    210                 215                 220                 


Gly Lys Val Cys Leu Glu Ser Ala Val Glu Leu Pro Lys Ile Leu Cys 
225                 230                 235                 240 


Gln Glu Glu Gln Asp Ala Tyr Arg Arg Ile His Ser Leu Thr His Leu 
                245                 250                 255     


Asp Ser Val Thr Lys Ile His Asn Gly Ser Val Phe Thr Lys Asn Leu 
            260                 265                 270         


Cys Ser Gln Met Ser Ala Val Ser Gly Pro Leu Leu Gln Trp Leu Glu 
        275                 280                 285             


Asp Arg Leu Glu Gln Asn Gln Gln His Leu Gln Glu Leu Gln Gln Glu 
    290                 295                 300                 


Lys Glu Glu Leu Met Gln Glu Leu Ser Ser Leu Glu 
305                 310                 315     


<210> 113
<211> 368
<212> PRT
<213> Homo sapiens

<400> 113
Ser Ser Phe Thr Ile Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His Thr Pro Ile Leu 
            20                  25                  30          


Arg Asp Phe Phe Leu Ser Asp Arg His Arg Cys Glu Met Pro Ser Pro 
        35                  40                  45              


Glu Leu Cys Leu Val Cys Glu Met Ser Ser Leu Phe Arg Glu Leu Tyr 
    50                  55                  60                  


Ser Gly Asn Pro Ser Pro His Val Pro Tyr Lys Leu Leu His Leu Val 
65                  70                  75                  80  


Trp Ile His Ala Arg His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His 
                85                  90                  95      


Glu Phe Leu Ile Ala Ala Leu Asp Val Leu His Arg His Cys Lys Gly 
            100                 105                 110         


Asp Asp Val Gly Lys Ala Ala Asn Asn Pro Asn His Cys Asn Cys Ile 
        115                 120                 125             


Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln 
    130                 135                 140                 


Ala Cys His Gly Val Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser 
145                 150                 155                 160 


Leu Asp Leu Pro Gly Ser Cys Thr Ser Phe Trp Pro Met Ser Pro Gly 
                165                 170                 175     


Arg Glu Ser Ser Val Asn Gly Glu Ser His Ile Pro Gly Ile Thr Thr 
            180                 185                 190         


Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg Pro Glu His Leu Gly Ser 
        195                 200                 205             


Ser Ala Lys Ile Lys Cys Gly Ser Cys Gln Ser Tyr Gln Glu Ser Thr 
    210                 215                 220                 


Lys Gln Leu Thr Met Asn Lys Leu Pro Val Val Ala Cys Phe His Phe 
225                 230                 235                 240 


Lys Arg Phe Glu His Ser Ala Lys Gln Arg Arg Lys Ile Thr Thr Tyr 
                245                 250                 255     


Ile Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe Met Ala Ser Ser 
            260                 265                 270         


Lys Glu Ser Arg Met Asn Gly Gln Leu Gln Leu Pro Thr Asn Ser Gly 
        275                 280                 285             


Asn Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val Val Asn His Gln Gly 
    290                 295                 300                 


Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile Arg His His Lys Asp 
305                 310                 315                 320 


Gln Trp Phe Lys Cys Asp Asp Ala Val Ile Thr Lys Ala Ser Ile Lys 
                325                 330                 335     


Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Val 
            340                 345                 350         


Leu Glu His Glu Ser Glu Lys Val Lys Glu Met Asn Thr Gln Ala Tyr 
        355                 360                 365             


<210> 114
<211> 353
<212> PRT
<213> Homo sapiens

<400> 114
Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys Glu Arg Arg Lys Lys 
1               5                   10                  15      


Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala Thr Cys Tyr Val Asn 
            20                  25                  30          


Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu Leu Arg Gln Ala Leu 
        35                  40                  45              


Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met Leu Gly Asp Gly Ile 
    50                  55                  60                  


Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile Cys Glu His Leu Gln 
65                  70                  75                  80  


Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg Arg Tyr Ile Asp Pro 
                85                  90                  95      


Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr Gly Gln Gln Gln Asp 
            100                 105                 110         


Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu Leu Glu Asp Thr Leu 
        115                 120                 125             


Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile Val Gln Gln Gln Phe 
    130                 135                 140                 


Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn Gln Cys Gly Arg Glu 
145                 150                 155                 160 


Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu Leu Asn Ile Gln Gly 
                165                 170                 175     


His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe Leu Lys Glu Glu Lys 
            180                 185                 190         


Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn Cys Gln Ser Lys Gln 
        195                 200                 205             


Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu Pro Cys Thr Leu Asn 
    210                 215                 220                 


Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln Thr Gly His Lys Lys 
225                 230                 235                 240 


Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile Leu Asp Met Glu Pro 
                245                 250                 255     


Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr Glu Leu Ser Ala Val 
            260                 265                 270         


Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly His Tyr Ile Ala His 
        275                 280                 285             


Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys Phe Asn Asp Glu Asp 
    290                 295                 300                 


Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu Gly Ile Glu Glu Asp 
305                 310                 315                 320 


Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys Pro Lys Cys Gly Lys 
                325                 330                 335     


Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu Val Tyr Arg Leu Gln 
            340                 345                 350         


Thr 
    


<210> 115
<211> 359
<212> PRT
<213> Homo sapiens

<400> 115
Thr Ala Ile Cys Ala Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Ile Leu Gln Ser Leu Ser Asn Ile Glu Gln Phe Cys Cys 
            20                  25                  30          


Tyr Phe Lys Glu Leu Pro Ala Val Glu Leu Arg Asn Gly Lys Thr Ala 
        35                  40                  45              


Gly Arg Arg Thr Tyr His Thr Arg Ser Gln Gly Asp Asn Asn Val Ser 
    50                  55                  60                  


Leu Val Glu Glu Phe Arg Lys Thr Leu Cys Ala Leu Trp Gln Gly Ser 
65                  70                  75                  80  


Gln Thr Ala Phe Ser Pro Glu Ser Leu Phe Tyr Val Val Trp Lys Ile 
                85                  90                  95      


Met Pro Asn Phe Arg Gly Tyr Gln Gln Gln Asp Ala His Glu Phe Met 
            100                 105                 110         


Arg Tyr Leu Leu Asp His Leu His Leu Glu Leu Gln Gly Gly Phe Asn 
        115                 120                 125             


Gly Val Ser Arg Ser Ala Ile Leu Gln Glu Asn Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Asn Lys Cys Cys Ile Asn Gly Ala Ser Thr Val Val Thr Ala Ile 
145                 150                 155                 160 


Phe Gly Gly Ile Leu Gln Asn Glu Val Asn Cys Leu Ile Cys Gly Thr 
                165                 170                 175     


Glu Ser Arg Lys Phe Asp Pro Phe Leu Asp Leu Ser Leu Asp Ile Pro 
            180                 185                 190         


Ser Gln Phe Arg Ser Lys Arg Ser Lys Asn Gln Glu Asn Gly Pro Val 
        195                 200                 205             


Cys Ser Leu Arg Asp Cys Leu Arg Ser Phe Thr Asp Leu Glu Glu Leu 
    210                 215                 220                 


Asp Glu Thr Glu Leu Tyr Met Cys His Lys Cys Lys Lys Lys Gln Lys 
225                 230                 235                 240 


Ser Thr Lys Lys Phe Trp Ile Gln Lys Leu Pro Lys Val Leu Cys Leu 
                245                 250                 255     


His Leu Lys Arg Phe His Trp Thr Ala Tyr Leu Arg Asn Lys Val Asp 
            260                 265                 270         


Thr Tyr Val Glu Phe Pro Leu Arg Gly Leu Asp Met Lys Cys Tyr Leu 
        275                 280                 285             


Leu Glu Pro Glu Asn Ser Gly Pro Glu Ser Cys Leu Tyr Asp Leu Ala 
    290                 295                 300                 


Ala Val Val Val His His Gly Ser Gly Val Gly Ser Gly His Tyr Thr 
305                 310                 315                 320 


Ala Tyr Ala Thr His Glu Gly Arg Trp Phe His Phe Asn Asp Ser Thr 
                325                 330                 335     


Val Thr Leu Thr Asp Glu Glu Thr Val Val Lys Ala Lys Ala Tyr Ile 
            340                 345                 350         


Leu Phe Tyr Val Glu His Gln 
        355                 


<210> 116
<211> 300
<212> PRT
<213> Homo sapiens

<400> 116
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 117
<211> 708
<212> PRT
<213> Homo sapiens

<400> 117
Leu Pro Phe Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn 
1               5                   10                  15      


Ser Ile Leu Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val 
            20                  25                  30          


Lys His Leu Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp 
        35                  40                  45              


Glu Ala Asn Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala 
    50                  55                  60                  


Ser Tyr Glu Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu 
                85                  90                  95      


Leu Ala Thr Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn 
            100                 105                 110         


Pro Met Tyr Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln 
        115                 120                 125             


Cys Ile Leu Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu 
    130                 135                 140                 


Glu Val Lys Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro 
145                 150                 155                 160 


His Pro Lys Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser 
                165                 170                 175     


Met Arg His Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly 
            180                 185                 190         


Lys Arg Lys Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys 
        195                 200                 205             


Leu Ser Lys Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg 
    210                 215                 220                 


Ser Lys Arg Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile 
225                 230                 235                 240 


Ile Pro Lys Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys 
                245                 250                 255     


Lys Ser Arg Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro 
            260                 265                 270         


Ser Ile Leu Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln 
        275                 280                 285             


Gly Val Lys Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp 
    290                 295                 300                 


Leu Gly Lys Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu 
305                 310                 315                 320 


Ser Pro Gly Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro 
                325                 330                 335     


Ile Asn Lys Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu 
            340                 345                 350         


Phe Gln Gly Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser 
        355                 360                 365             


Leu Thr Glu Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln 
    370                 375                 380                 


Glu Asp Glu Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu 
385                 390                 395                 400 


Pro Lys Thr Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala 
                405                 410                 415     


Ser Val Glu Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys 
            420                 425                 430         


His His Tyr Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro 
        435                 440                 445             


Glu Val Ile Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu 
    450                 455                 460                 


Phe Asp Cys Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu 
465                 470                 475                 480 


Thr Pro Leu Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn 
                485                 490                 495     


Asp Ser Tyr Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile 
            500                 505                 510         


Ser Ser Gly His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser 
        515                 520                 525             


Leu Glu Leu Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile 
    530                 535                 540                 


Gly Lys Pro Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu 
545                 550                 555                 560 


Asn Tyr Asn Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln 
                565                 570                 575     


Pro Ser Lys Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu 
            580                 585                 590         


Gly Gly Gln Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser 
        595                 600                 605             


Asn Pro Asp Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser 
    610                 615                 620                 


Glu Thr Ser Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu 
625                 630                 635                 640 


Ser Ser Asp Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile 
                645                 650                 655     


Ser Tyr Val Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu 
            660                 665                 670         


Phe Asp Asp Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn 
        675                 680                 685             


Ser Leu Ser Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe 
    690                 695                 700                 


Tyr Lys Lys Leu 
705             


<210> 118
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 118
Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly Thr Cys Tyr Leu 
1               5                   10                  15      


Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu Phe Arg Glu Ala 
            20                  25                  30          


Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe Glu Asp Lys Asp 
        35                  40                  45              


Lys Pro Asp Ala Lys Val Arg Ile Ile Pro Leu Gln Leu Gln Arg Leu 
    50                  55                  60                  


Phe Ala Gln Leu Leu Leu Leu Asp Gln Glu Ala Ala Ser Thr Ala Asp 
65                  70                  75                  80  


Leu Thr Asp Ser Phe Gly Trp Thr Ser Asn Glu Glu Met Arg Gln His 
                85                  90                  95      


Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala Leu Glu Thr Ser 
            100                 105                 110         


Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg Leu Tyr His Gly 
        115                 120                 125             


Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys Asn Val Ser Glu 
    130                 135                 140                 


Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val Lys Asn Val Ser 
145                 150                 155                 160 


Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu Glu Glu Val Phe 
                165                 170                 175     


Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp Arg Leu Val Lys 
            180                 185                 190         


Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro Phe Leu Thr Val 
        195                 200                 205             


Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys Glu Arg Tyr Lys 
    210                 215                 220                 


Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn Leu Lys Pro Phe 
225                 230                 235                 240 


Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile Tyr Asp Leu Phe 
                245                 250                 255     


Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly His Tyr His Val 
            260                 265                 270         


Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln Phe Gln Glu Glu 
        275                 280                 285             


Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln Ser Glu Glu Glu 
    290                 295                 300                 


Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu Leu Glu Glu Asn 
305                 310                 315                 320 


Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu Leu Lys Lys Ile 
                325                 330                 335     


Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His Gly Pro Leu Arg 
            340                 345                 350         


Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu Ser Ser Asp Glu 
        355                 360                 365             


Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln Ala Glu Ser Asp 
    370                 375                 380                 


Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu Pro Pro Glu Ser 
385                 390                 395                 400 


Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp Phe Asp Ile Asn 
                405                 410                 415     


Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile Glu Gln Gln Phe 
            420                 425                 430         


Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg Lys Ser Gln Leu 
        435                 440                 445             


Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr Gly Val Pro Cys 
    450                 455                 460                 


His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu Leu Gln Thr Lys 
465                 470                 475                 480 


Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu Leu His Leu His 
                485                 490                 495     


Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu His Pro Val Val 
            500                 505                 510         


Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp Lys Arg Lys Thr 
        515                 520                 525             


Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu Glu Phe Trp Glu 
    530                 535                 540                 


Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro Ala Gly Leu His 
545                 550                 555                 560 


Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu Cys Glu Thr Glu 
                565                 570                 575     


Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly Val Glu Val Gly 
            580                 585                 590         


Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro Leu Leu Leu Asn 
        595                 600                 605             


Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys Cys Cys Gln Val 
    610                 615                 620                 


Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu Val Gly Thr Val 
625                 630                 635                 640 


Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe Ile Asn Ser Ala 
                645                 650                 655     


Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro Lys Glu Asp Met 
            660                 665                 670         


Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly Ser Ser Ile Leu 
        675                 680                 685             


Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr Lys Glu Glu Lys 
    690                 695                 700                 


Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His Val Lys Asn Leu 
705                 710                 715                 720 


Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile Ser Ala Thr Val 
                725                 730                 735     


Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile Lys Glu Leu Lys 
            740                 745                 750         


Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg Pro Ile Asp Arg 
        755                 760                 765             


Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr Thr Leu Lys Glu 
    770                 775                 780                 


Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys Leu Gly Lys Ala 
785                 790                 795                 800 


Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met Gly Ser Asp Val 
                805                 810                 815     


Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu Thr Ile Ser Val 
            820                 825                 830         


Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly Leu Gln Gly Asp 
        835                 840                 845             


Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu Ala Gly Glu Pro 
    850                 855                 860                 


Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu Ile Cys Ser Gly 
865                 870                 875                 880 


Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro Leu Gly Phe Leu 
                885                 890                 895     


Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro Ser Gly His Trp 
            900                 905                 910         


Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser Trp Gly Arg Val 
        915                 920                 925             


Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn Glu Pro Ala Gln 
    930                 935                 940                 


Val Ser Leu Leu Tyr Leu Gly Asp Ile Glu Ile Ser Glu Asp Ala Thr 
945                 950                 955                 960 


Leu Ala Glu Leu Lys Ser Gln Ala Met Thr Leu Pro Pro Phe Leu Glu 
                965                 970                 975     


Phe Gly Val Pro Ser Pro Ala His Leu Arg Ala Trp Thr Val Glu Arg 
            980                 985                 990         


Lys Arg Pro Gly Arg Leu Leu Arg  Thr Asp Arg Gln Pro  Leu Arg Glu 
        995                 1000                 1005             


Tyr Lys  Leu Gly Arg Arg Ile  Glu Ile Cys Leu Glu  Pro Leu Gln 
    1010                 1015                 1020             


Lys Gly  Glu Asn Leu Gly Pro  Gln Asp Val Leu Leu  Arg Thr Gln 
    1025                 1030                 1035             


Val Arg  Ile Pro Gly Glu Arg  Thr Tyr Ala Pro Ala  Leu Asp Leu 
    1040                 1045                 1050             


Val Trp  Asn Ala Ala Gln Gly  Gly Thr Ala Gly Ser  Leu Arg Gln 
    1055                 1060                 1065             


Arg Val  Ala Asp Phe Tyr Arg  Leu Pro Val Glu Lys  Ile Glu Ile 
    1070                 1075                 1080             


Ala Lys  Tyr Phe Pro Glu Lys  Phe Glu Trp Leu Pro  Ile Ser Ser 
    1085                 1090                 1095             


Trp Asn  Gln Gln Ile Thr Lys  Arg Lys Lys Lys Lys  Lys Gln Asp 
    1100                 1105                 1110             


Tyr Leu  Gln Gly Ala Pro Tyr  Tyr Leu Lys Asp Gly  Asp Thr Ile 
    1115                 1120                 1125             


Gly Val  Lys Asn Leu Leu Ile  Asp Asp Asp Asp Asp  Phe Ser Thr 
    1130                 1135                 1140             


Ile Arg  Asp Asp Thr Gly Lys  Glu Lys Gln Lys Gln  Arg Ala Leu 
    1145                 1150                 1155             


Gly Arg  Arg Lys Ser Gln 
    1160                 


<210> 119
<211> 311
<212> PRT
<213> Homo sapiens

<400> 119
Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys Ala Val 
            20                  25                  30          


Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val Pro Leu 
        35                  40                  45              


Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys Pro Val 
    50                  55                  60                  


Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu Asp Ser 
65                  70                  75                  80  


Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu Asp Asn 
                85                  90                  95      


Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile Pro Lys 
            100                 105                 110         


Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu Val Asp 
        115                 120                 125             


Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu Ser Ile 
    130                 135                 140                 


Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val Ala Val 
145                 150                 155                 160 


Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His Gly Leu 
                165                 170                 175     


Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro Val Leu 
            180                 185                 190         


His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp Gln Asn 
        195                 200                 205             


Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro Leu Asp 
    210                 215                 220                 


Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr Ile Leu 
225                 230                 235                 240 


His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His Tyr Val 
                245                 250                 255     


Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe Asp Asp 
            260                 265                 270         


Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His Asn Tyr 
        275                 280                 285             


Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn Ala Tyr 
    290                 295                 300                 


Met Leu Val Tyr Ile Arg Glu 
305                 310     


<210> 120
<211> 344
<212> PRT
<213> Homo sapiens

<400> 120
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Ala Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 121
<211> 344
<212> PRT
<213> Homo sapiens

<400> 121
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Leu Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 122
<211> 344
<212> PRT
<213> Homo sapiens

<400> 122
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Lys Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Phe Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Ile Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Arg Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp Arg His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Asn Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Pro 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Ser Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Val 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 123
<211> 307
<212> PRT
<213> Homo sapiens

<400> 123
Trp Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys Cys Leu Asn 
1               5                   10                  15      


Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Ala Arg Ile Leu 
            20                  25                  30          


Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg Arg Ser Val 
        35                  40                  45              


Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp Ser Arg Gln 
    50                  55                  60                  


Lys Ala Val Trp Pro Leu Glu Leu Ala Tyr Cys Leu Gln Lys Tyr Asn 
65                  70                  75                  80  


Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr Leu Lys Leu 
                85                  90                  95      


Trp Asn Leu Ile Lys Asp Gln Ile Ala Asp Val His Leu Val Glu Arg 
            100                 105                 110         


Leu Gln Ala Leu Tyr Met Ile Arg Met Lys Asp Ser Leu Ile Cys Leu 
        115                 120                 125             


Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu Thr Leu Arg 
    130                 135                 140                 


Leu Ser Phe Phe Asp Val Asp Ser Lys Pro Leu Lys Thr Leu Glu Asp 
145                 150                 155                 160 


Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser Lys Ser Lys 
                165                 170                 175     


Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys Gln Val Leu 
            180                 185                 190         


Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu Met Arg Phe 
        195                 200                 205             


Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser Leu Tyr Phe 
    210                 215                 220                 


Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys Arg Glu Ser 
225                 230                 235                 240 


Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu Phe Ala Val 
                245                 250                 255     


Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys Val Tyr Ile 
            260                 265                 270         


Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp Ser Asn Ile 
        275                 280                 285             


Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly Asn Pro Asn 
    290                 295                 300                 


Tyr His Trp 
305         


<210> 124
<211> 511
<212> PRT
<213> Homo sapiens

<400> 124
Ser Glu Thr Gly Lys Thr Gly Leu Ile Asn Leu Gly Asn Thr Cys Tyr 
1               5                   10                  15      


Met Asn Ser Val Ile Gln Ala Leu Phe Met Ala Thr Asp Phe Arg Arg 
            20                  25                  30          


Gln Val Leu Ser Leu Asn Leu Asn Gly Cys Asn Ser Leu Met Lys Lys 
        35                  40                  45              


Leu Gln His Leu Phe Ala Phe Leu Ala His Thr Gln Arg Glu Ala Tyr 
    50                  55                  60                  


Ala Pro Arg Ile Phe Phe Glu Ala Ser Arg Pro Pro Trp Phe Thr Pro 
65                  70                  75                  80  


Arg Ser Gln Gln Asp Cys Ser Glu Tyr Leu Arg Phe Leu Leu Asp Arg 
                85                  90                  95      


Leu His Glu Glu Glu Lys Ile Leu Lys Val Gln Ala Ser His Lys Pro 
            100                 105                 110         


Ser Glu Ile Leu Glu Cys Ser Glu Thr Ser Leu Gln Glu Val Ala Ser 
        115                 120                 125             


Lys Ala Ala Val Leu Thr Glu Thr Pro Arg Thr Ser Asp Gly Glu Lys 
    130                 135                 140                 


Thr Leu Ile Glu Lys Met Phe Gly Gly Lys Leu Arg Thr His Ile Arg 
145                 150                 155                 160 


Cys Leu Asn Cys Arg Ser Thr Ser Gln Lys Val Glu Ala Phe Thr Asp 
                165                 170                 175     


Leu Ser Leu Ala Phe Cys Pro Ser Ser Ser Leu Glu Asn Met Ser Val 
            180                 185                 190         


Gln Asp Pro Ala Ser Ser Pro Ser Ile Gln Asp Gly Gly Leu Met Gln 
        195                 200                 205             


Ala Ser Val Pro Gly Pro Ser Glu Glu Pro Val Val Tyr Asn Pro Thr 
    210                 215                 220                 


Thr Ala Ala Phe Ile Cys Asp Ser Leu Val Asn Glu Lys Thr Ile Gly 
225                 230                 235                 240 


Ser Pro Pro Asn Glu Phe Tyr Cys Ser Glu Asn Thr Ser Val Pro Asn 
                245                 250                 255     


Glu Ser Asn Lys Ile Leu Val Asn Lys Asp Val Pro Gln Lys Pro Gly 
            260                 265                 270         


Gly Glu Thr Thr Pro Ser Val Thr Asp Leu Leu Asn Tyr Phe Leu Ala 
        275                 280                 285             


Pro Glu Ile Leu Thr Gly Asp Asn Gln Tyr Tyr Cys Glu Asn Cys Ala 
    290                 295                 300                 


Ser Leu Gln Asn Ala Glu Lys Thr Met Gln Ile Thr Glu Glu Pro Glu 
305                 310                 315                 320 


Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Tyr Asp Gln Lys Tyr His 
                325                 330                 335     


Val Arg Arg Lys Ile Leu Asp Asn Val Ser Leu Pro Leu Val Leu Glu 
            340                 345                 350         


Leu Pro Val Lys Arg Ile Thr Ser Phe Ser Ser Leu Ser Glu Ser Trp 
        355                 360                 365             


Ser Val Asp Val Asp Phe Thr Asp Leu Ser Glu Asn Leu Ala Lys Lys 
    370                 375                 380                 


Leu Lys Pro Ser Gly Thr Asp Glu Ala Ser Cys Thr Lys Leu Val Pro 
385                 390                 395                 400 


Tyr Leu Leu Ser Ser Val Val Val His Ser Gly Ile Ser Ser Glu Ser 
                405                 410                 415     


Gly His Tyr Tyr Ser Tyr Ala Arg Asn Ile Thr Ser Thr Asp Ser Ser 
            420                 425                 430         


Tyr Gln Met Tyr His Gln Ser Glu Ala Leu Ala Leu Ala Ser Ser Gln 
        435                 440                 445             


Ser His Leu Leu Gly Arg Asp Ser Pro Ser Ala Val Phe Glu Gln Asp 
    450                 455                 460                 


Leu Glu Asn Lys Glu Met Ser Lys Glu Trp Phe Leu Phe Asn Asp Ser 
465                 470                 475                 480 


Arg Val Thr Phe Thr Ser Phe Gln Ser Val Gln Lys Ile Thr Ser Arg 
                485                 490                 495     


Phe Pro Lys Asp Thr Ala Tyr Val Leu Leu Tyr Lys Lys Gln His 
            500                 505                 510     


<210> 125
<211> 616
<212> PRT
<213> Homo sapiens

<400> 125
Arg Pro Pro Gly Ala Gln Gly Leu Lys Asn His Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Val Val Gln Cys Leu Ser Asn Thr Asp Leu Leu Ala Glu 
            20                  25                  30          


Phe Leu Ala Leu Gly Arg Tyr Arg Ala Ala Pro Gly Arg Ala Glu Val 
        35                  40                  45              


Thr Glu Gln Leu Ala Ala Leu Val Arg Ala Leu Trp Thr Arg Glu Tyr 
    50                  55                  60                  


Thr Pro Gln Leu Ser Ala Glu Phe Lys Asn Ala Val Ser Lys Tyr Gly 
65                  70                  75                  80  


Ser Gln Phe Gln Gly Asn Ser Gln His Asp Ala Leu Glu Phe Leu Leu 
                85                  90                  95      


Trp Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly Ser Ser Arg Gly 
            100                 105                 110         


Pro Val Ser Glu Lys Leu Pro Pro Glu Ala Thr Lys Thr Ser Glu Asn 
        115                 120                 125             


Cys Leu Ser Pro Ser Ala Gln Leu Pro Leu Gly Gln Ser Phe Val Gln 
    130                 135                 140                 


Ser His Phe Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys 
145                 150                 155                 160 


Leu Lys Gln Ser Asn Thr Phe Asp Pro Phe Leu Cys Val Ser Leu Pro 
                165                 170                 175     


Ile Pro Leu Arg Gln Thr Arg Phe Leu Ser Val Thr Leu Val Phe Pro 
            180                 185                 190         


Ser Lys Ser Gln Arg Phe Leu Arg Val Gly Leu Ala Val Pro Ile Leu 
        195                 200                 205             


Ser Thr Val Ala Ala Leu Arg Lys Met Val Ala Glu Glu Gly Gly Val 
    210                 215                 220                 


Pro Ala Asp Glu Val Ile Leu Val Glu Leu Tyr Pro Ser Gly Phe Gln 
225                 230                 235                 240 


Arg Ser Phe Phe Asp Glu Glu Asp Leu Asn Thr Ile Ala Glu Gly Asp 
                245                 250                 255     


Asn Val Tyr Ala Phe Gln Val Pro Pro Ser Pro Ser Gln Gly Thr Leu 
            260                 265                 270         


Ser Ala His Pro Leu Gly Leu Ser Ala Ser Pro Arg Leu Ala Ala Arg 
        275                 280                 285             


Glu Gly Gln Arg Phe Ser Leu Ser Leu His Ser Glu Ser Lys Val Leu 
    290                 295                 300                 


Ile Leu Phe Cys Asn Leu Val Gly Ser Gly Gln Gln Ala Ser Arg Phe 
305                 310                 315                 320 


Gly Pro Pro Phe Leu Ile Arg Glu Asp Arg Ala Val Ser Trp Ala Gln 
                325                 330                 335     


Leu Gln Gln Ser Ile Leu Ser Lys Val Arg His Leu Met Lys Ser Glu 
            340                 345                 350         


Ala Pro Val Gln Asn Leu Gly Ser Leu Phe Ser Ile Arg Val Val Gly 
        355                 360                 365             


Leu Ser Val Ala Cys Ser Tyr Leu Ser Pro Lys Asp Ser Arg Pro Leu 
    370                 375                 380                 


Cys His Trp Ala Val Asp Arg Val Leu His Leu Arg Arg Pro Gly Gly 
385                 390                 395                 400 


Pro Pro His Val Lys Leu Ala Val Glu Trp Asp Ser Ser Val Lys Glu 
                405                 410                 415     


Arg Leu Phe Gly Ser Leu Gln Glu Glu Arg Ala Gln Asp Ala Asp Ser 
            420                 425                 430         


Val Trp Gln Gln Gln Gln Ala His Gln Gln His Ser Cys Thr Leu Asp 
        435                 440                 445             


Glu Cys Phe Gln Phe Tyr Thr Lys Glu Glu Gln Leu Ala Gln Asp Asp 
    450                 455                 460                 


Ala Trp Lys Cys Pro His Cys Gln Val Leu Gln Gln Gly Met Val Lys 
465                 470                 475                 480 


Leu Ser Leu Trp Thr Leu Pro Asp Ile Leu Ile Ile His Leu Lys Arg 
                485                 490                 495     


Phe Cys Gln Val Gly Glu Arg Arg Asn Lys Leu Ser Thr Leu Val Lys 
            500                 505                 510         


Phe Pro Leu Ser Gly Leu Asn Met Ala Pro His Val Ala Gln Arg Ser 
        515                 520                 525             


Thr Ser Pro Glu Ala Gly Leu Gly Pro Trp Pro Ser Trp Lys Gln Pro 
    530                 535                 540                 


Asp Cys Leu Pro Thr Ser Tyr Pro Leu Asp Phe Leu Tyr Asp Leu Tyr 
545                 550                 555                 560 


Ala Val Cys Asn His His Gly Asn Leu Gln Gly Gly His Tyr Thr Ala 
                565                 570                 575     


Tyr Cys Arg Asn Ser Leu Asp Gly Gln Trp Tyr Ser Tyr Asp Asp Ser 
            580                 585                 590         


Thr Val Glu Pro Leu Arg Glu Asp Glu Val Asn Thr Arg Gly Ala Tyr 
        595                 600                 605             


Ile Leu Phe Tyr Gln Lys Arg Asn 
    610                 615     


<210> 126
<211> 339
<212> PRT
<213> Homo sapiens

<400> 126
Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp 
            20                  25                  30          


Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn 
        35                  40                  45              


Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile 
    50                  55                  60                  


Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr 
65                  70                  75                  80  


Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp 
                85                  90                  95      


Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val 
            100                 105                 110         


Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His 
        115                 120                 125             


Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu 
    130                 135                 140                 


Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser 
145                 150                 155                 160 


Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro 
                165                 170                 175     


Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val 
            180                 185                 190         


Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp 
        195                 200                 205             


Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys 
    210                 215                 220                 


Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His 
225                 230                 235                 240 


Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr 
                245                 250                 255     


Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser 
            260                 265                 270         


Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His 
        275                 280                 285             


Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro 
    290                 295                 300                 


Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met 
305                 310                 315                 320 


Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu 
                325                 330                 335     


Leu Ala Ser 
            


<210> 127
<211> 628
<212> PRT
<213> Homo sapiens

<400> 127
Leu Ser Val Arg Gly Ile Thr Asn Leu Gly Asn Thr Cys Phe Phe Asn 
1               5                   10                  15      


Ala Val Met Gln Asn Leu Ala Gln Thr Tyr Thr Leu Thr Asp Leu Met 
            20                  25                  30          


Asn Glu Ile Lys Glu Ser Ser Thr Lys Leu Lys Ile Phe Pro Ser Ser 
        35                  40                  45              


Asp Ser Gln Leu Asp Pro Leu Val Val Glu Leu Ser Arg Pro Gly Pro 
    50                  55                  60                  


Leu Thr Ser Ala Leu Phe Leu Phe Leu His Ser Met Lys Glu Thr Glu 
65                  70                  75                  80  


Lys Gly Pro Leu Ser Pro Lys Val Leu Phe Asn Gln Leu Cys Gln Lys 
                85                  90                  95      


Ala Pro Arg Phe Lys Asp Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu 
            100                 105                 110         


His Tyr Leu Leu Asp Ala Val Arg Thr Glu Glu Thr Lys Arg Ile Gln 
        115                 120                 125             


Ala Ser Ile Leu Lys Ala Phe Asn Asn Pro Thr Thr Lys Thr Ala Asp 
    130                 135                 140                 


Asp Glu Thr Arg Lys Lys Val Lys Ala Tyr Gly Lys Glu Gly Val Lys 
145                 150                 155                 160 


Met Asn Phe Ile Asp Arg Ile Phe Ile Gly Glu Leu Thr Ser Thr Val 
                165                 170                 175     


Met Cys Glu Glu Cys Ala Asn Ile Ser Thr Val Lys Asp Pro Phe Ile 
            180                 185                 190         


Asp Ile Ser Leu Pro Ile Ile Glu Glu Arg Val Ser Lys Pro Leu Leu 
        195                 200                 205             


Trp Gly Arg Met Asn Lys Tyr Arg Ser Leu Arg Glu Thr Asp His Asp 
    210                 215                 220                 


Arg Tyr Ser Gly Asn Val Thr Ile Glu Asn Ile His Gln Pro Arg Ala 
225                 230                 235                 240 


Ala Lys Lys His Ser Ser Ser Lys Asp Lys Ser Gln Leu Ile His Asp 
                245                 250                 255     


Arg Lys Cys Ile Arg Lys Leu Ser Ser Gly Glu Thr Val Thr Tyr Gln 
            260                 265                 270         


Lys Asn Glu Asn Leu Glu Met Asn Gly Asp Ser Leu Met Phe Ala Ser 
        275                 280                 285             


Leu Met Asn Ser Glu Ser Arg Leu Asn Glu Ser Pro Thr Asp Asp Ser 
    290                 295                 300                 


Glu Lys Glu Ala Ser His Ser Glu Ser Asn Val Asp Ala Asp Ser Glu 
305                 310                 315                 320 


Pro Ser Glu Ser Glu Ser Ala Ser Lys Gln Thr Gly Leu Phe Arg Ser 
                325                 330                 335     


Ser Ser Gly Ser Gly Val Gln Pro Asp Gly Pro Leu Tyr Pro Leu Ser 
            340                 345                 350         


Ala Gly Lys Leu Leu Tyr Thr Lys Glu Thr Asp Ser Gly Asp Lys Glu 
        355                 360                 365             


Met Ala Glu Ala Ile Ser Glu Leu Arg Leu Ser Ser Thr Val Thr Gly 
    370                 375                 380                 


Asp Gln Asp Phe Asp Arg Glu Asn Gln Pro Leu Asn Ile Ser Asn Asn 
385                 390                 395                 400 


Leu Cys Phe Leu Glu Gly Lys His Leu Arg Ser Tyr Ser Pro Gln Asn 
                405                 410                 415     


Ala Phe Gln Thr Leu Ser Gln Ser Tyr Ile Thr Thr Ser Lys Glu Cys 
            420                 425                 430         


Ser Ile Gln Ser Cys Leu Tyr Gln Phe Thr Ser Met Glu Leu Leu Met 
        435                 440                 445             


Gly Asn Asn Lys Leu Leu Cys Glu Asn Cys Thr Lys Asn Lys Gln Lys 
    450                 455                 460                 


Tyr Gln Glu Glu Thr Ser Phe Ala Glu Lys Lys Val Glu Gly Val Tyr 
465                 470                 475                 480 


Thr Asn Ala Arg Lys Gln Leu Leu Ile Ser Ala Val Pro Ala Val Leu 
                485                 490                 495     


Ile Leu His Leu Lys Arg Phe His Gln Ala Gly Leu Ser Leu Arg Lys 
            500                 505                 510         


Val Asn Arg His Val Asp Phe Pro Leu Met Leu Asp Leu Ala Pro Phe 
        515                 520                 525             


Cys Ser Ala Thr Cys Lys Asn Ala Ser Val Gly Asp Lys Val Leu Tyr 
    530                 535                 540                 


Gly Leu Tyr Gly Ile Val Glu His Ser Gly Ser Met Arg Glu Gly His 
545                 550                 555                 560 


Tyr Thr Ala Tyr Val Lys Val Arg Thr Pro Ser Arg Lys Leu Ser Glu 
                565                 570                 575     


His Asn Thr Lys Lys Lys Asn Val Pro Gly Leu Lys Ala Ala Asp Asn 
            580                 585                 590         


Glu Ser Ala Gly Gln Trp Val His Val Ser Asp Thr Tyr Leu Gln Val 
        595                 600                 605             


Val Pro Glu Ser Arg Ala Leu Ser Ala Gln Ala Tyr Leu Leu Phe Tyr 
    610                 615                 620                 


Glu Arg Val Leu 
625             


<210> 128
<211> 876
<212> PRT
<213> Homo sapiens

<400> 128
Thr Glu Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln 
            20                  25                  30          


Tyr Phe Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro 
        35                  40                  45              


Ile Gly Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln 
    50                  55                  60                  


Glu Leu Trp Ser Gly Thr Gln Lys Asn Val Ala Pro Leu Lys Leu Arg 
65                  70                  75                  80  


Trp Thr Ile Ala Lys Tyr Ala Pro Arg Phe Asn Gly Phe Gln Gln Gln 
                85                  90                  95      


Asp Ser Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp 
            100                 105                 110         


Leu Asn Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp 
        115                 120                 125             


Gly Arg Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu 
    130                 135                 140                 


Arg Arg Asn Arg Ser Ile Val Val Asp Leu Phe His Gly Gln Leu Arg 
145                 150                 155                 160 


Ser Gln Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp 
                165                 170                 175     


Pro Phe Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met His 
            180                 185                 190         


Leu Glu Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr 
        195                 200                 205             


Gly Leu Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln 
    210                 215                 220                 


Leu Ser Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu 
225                 230                 235                 240 


Val His Gly Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val 
                245                 250                 255     


Arg Leu Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro 
            260                 265                 270         


Val Ser Pro Ile Ser Ala Ser Ser Pro Thr Gln Thr Asp Phe Ser Ser 
        275                 280                 285             


Ser Pro Ser Thr Asn Glu Met Phe Thr Leu Thr Thr Asn Gly Asp Leu 
    290                 295                 300                 


Pro Arg Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro 
305                 310                 315                 320 


Cys Gly Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met 
                325                 330                 335     


Pro Ser Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His 
            340                 345                 350         


Arg Lys Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Ser Gln Lys Asn 
        355                 360                 365             


Arg Pro Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His 
    370                 375                 380                 


Thr Arg Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Arg 
385                 390                 395                 400 


Leu Ala Ser Pro Leu Pro Pro Gln Glu Ala Ser Asn His Ala Gln Asp 
                405                 410                 415     


Cys Asp Asp Ser Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val 
            420                 425                 430         


Gln Lys Asp Gly Asn Ser Cys Ala Trp Cys Pro Trp Tyr Arg Phe Cys 
        435                 440                 445             


Arg Gly Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn 
    450                 455                 460                 


Ala Tyr Ile Ala Val Asp Trp Asp Pro Thr Ala Leu His Leu Arg Tyr 
465                 470                 475                 480 


Gln Thr Ser Gln Glu Arg Val Val Asp Glu His Glu Ser Val Glu Gln 
                485                 490                 495     


Ser Arg Arg Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg 
            500                 505                 510         


Ala Phe Thr Ser Glu Glu Glu Leu Gly Glu Asn Glu Met Tyr Tyr Cys 
        515                 520                 525             


Ser Lys Cys Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp 
    530                 535                 540                 


Arg Leu Pro Pro Ile Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val 
545                 550                 555                 560 


Asn Gly Arg Trp Ile Lys Ser Gln Lys Ile Val Lys Phe Pro Arg Glu 
                565                 570                 575     


Ser Phe Asp Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys 
            580                 585                 590         


Gln His Lys Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Glu Pro Arg 
        595                 600                 605             


Ile Leu Ala Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly 
    610                 615                 620                 


Glu Glu Asp Val Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn 
625                 630                 635                 640 


Ile Ile Ser Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly 
                645                 650                 655     


Thr Ser Cys Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg 
            660                 665                 670         


Thr Leu Gly Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser 
        675                 680                 685             


Lys Asn Lys Leu Ser Ser Ser Lys Glu Asn Leu Asp Ala Ser Lys Glu 
    690                 695                 700                 


Asn Gly Ala Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly 
705                 710                 715                 720 


His Val Leu Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His 
                725                 730                 735     


Glu Val Ala Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly 
            740                 745                 750         


Asn Gly Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu Asp Ser 
        755                 760                 765             


Thr Asp Asp Gln Arg Glu Asp Thr Arg Ile Lys Pro Ile Tyr Asn Leu 
    770                 775                 780                 


Tyr Ala Ile Ser Cys His Ser Gly Ile Leu Gly Gly Gly His Tyr Val 
785                 790                 795                 800 


Thr Tyr Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn Asp Ser 
                805                 810                 815     


Ser Cys Lys Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser Ala Tyr 
            820                 825                 830         


Ile Leu Phe Tyr Glu Gln Gln Gly Ile Asp Tyr Ala Gln Phe Leu Pro 
        835                 840                 845             


Lys Thr Asp Gly Lys Lys Met Ala Asp Thr Ser Ser Met Asp Glu Asp 
    850                 855                 860                 


Phe Glu Ser Asp Tyr Lys Lys Tyr Cys Val Leu Gln 
865                 870                 875     


<210> 129
<211> 300
<212> PRT
<213> Homo sapiens

<400> 129
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 130
<211> 313
<212> PRT
<213> Homo sapiens

<400> 130
Arg Val Gly Ala Gly Leu Gln Asn Leu Gly Asn Thr Cys Phe Ala Asn 
1               5                   10                  15      


Ala Ala Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser His Glu His Ser Lys Thr Cys His Ala Glu Gly Phe Cys Met 
        35                  40                  45              


Met Cys Thr Met Gln Ala His Ile Thr Gln Ala Leu Ser Asn Pro Gly 
    50                  55                  60                  


Asp Val Ile Lys Pro Met Phe Val Ile Asn Glu Met Arg Arg Ile Ala 
65                  70                  75                  80  


Arg His Phe Arg Phe Gly Asn Gln Glu Asp Ala His Glu Phe Leu Gln 
                85                  90                  95      


Tyr Thr Val Asp Ala Met Gln Lys Ala Cys Leu Asn Gly Ser Asn Lys 
            100                 105                 110         


Leu Asp Arg His Thr Gln Ala Thr Thr Leu Val Cys Gln Ile Phe Gly 
        115                 120                 125             


Gly Tyr Leu Arg Ser Arg Val Lys Cys Leu Asn Cys Lys Gly Val Ser 
    130                 135                 140                 


Asp Thr Phe Asp Pro Tyr Leu Asp Ile Thr Leu Glu Ile Lys Ala Ala 
145                 150                 155                 160 


Gln Ser Val Asn Lys Ala Leu Glu Gln Phe Val Lys Pro Glu Gln Leu 
                165                 170                 175     


Asp Gly Glu Asn Ser Tyr Lys Cys Ser Lys Cys Lys Lys Met Val Pro 
            180                 185                 190         


Ala Ser Lys Arg Phe Thr Ile His Arg Ser Ser Asn Val Leu Thr Leu 
        195                 200                 205             


Ser Leu Lys Arg Phe Ala Asn Phe Thr Gly Gly Lys Ile Ala Lys Asp 
    210                 215                 220                 


Val Lys Tyr Pro Glu Tyr Leu Asp Ile Arg Pro Tyr Met Ser Gln Pro 
225                 230                 235                 240 


Asn Gly Glu Pro Ile Val Tyr Val Leu Tyr Ala Val Leu Val His Thr 
                245                 250                 255     


Gly Phe Asn Cys His Ala Gly His Tyr Phe Cys Tyr Ile Lys Ala Ser 
            260                 265                 270         


Asn Gly Leu Trp Tyr Gln Met Asn Asp Ser Ile Val Ser Thr Ser Asp 
        275                 280                 285             


Ile Arg Ser Val Leu Ser Gln Gln Ala Tyr Val Leu Phe Tyr Ile Arg 
    290                 295                 300                 


Ser His Asp Val Lys Asn Gly Gly Glu 
305                 310             


<210> 131
<211> 344
<212> PRT
<213> Homo sapiens

<400> 131
Ala Val Gly Ala Gly Leu Gln Lys Ile Gly Asn Thr Phe Tyr Val Asn 
1               5                   10                  15      


Val Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ser Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu Asp Ser Gln Thr Cys His Leu His Lys Cys Cys Met 
        35                  40                  45              


Phe Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Val Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Glu Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Leu Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Ala Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Tyr Leu His Cys His Gly Val Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Lys Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Lys Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu Pro Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Lys Cys 
    210                 215                 220                 


Arg Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Gly Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Val Pro Glu Leu 
            340                 


<210> 132
<211> 344
<212> PRT
<213> Homo sapiens

<400> 132
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 133
<211> 533
<212> PRT
<213> Homo sapiens

<400> 133
Tyr Gly Pro Gly Tyr Thr Gly Leu Lys Asn Leu Gly Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Ser Ser Val Met Gln Ala Ile Phe Ser Ile Pro Glu Phe Gln Arg 
            20                  25                  30          


Ala Tyr Val Gly Asn Leu Pro Arg Ile Phe Asp Tyr Ser Pro Leu Asp 
        35                  40                  45              


Pro Thr Gln Asp Phe Asn Thr Gln Met Thr Lys Leu Gly His Gly Leu 
    50                  55                  60                  


Leu Ser Gly Gln Tyr Ser Lys Pro Pro Val Lys Ser Glu Leu Ile Glu 
65                  70                  75                  80  


Gln Val Met Lys Glu Glu His Lys Pro Gln Gln Asn Gly Ile Ser Pro 
                85                  90                  95      


Arg Met Phe Lys Ala Phe Val Ser Lys Ser His Pro Glu Phe Ser Ser 
            100                 105                 110         


Asn Arg Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Val Asn Leu 
        115                 120                 125             


Val Glu Arg Asn Arg Ile Gly Ser Glu Asn Pro Ser Asp Val Phe Arg 
    130                 135                 140                 


Phe Leu Val Glu Glu Arg Ile Gln Cys Cys Gln Thr Arg Lys Val Arg 
145                 150                 155                 160 


Tyr Thr Glu Arg Val Asp Tyr Leu Met Gln Leu Pro Val Ala Met Glu 
                165                 170                 175     


Ala Ala Thr Asn Lys Asp Glu Leu Ile Ala Tyr Glu Leu Thr Arg Arg 
            180                 185                 190         


Glu Ala Glu Ala Asn Arg Arg Pro Leu Pro Glu Leu Val Arg Ala Lys 
        195                 200                 205             


Ile Pro Phe Ser Ala Cys Leu Gln Ala Phe Ser Glu Pro Glu Asn Val 
    210                 215                 220                 


Asp Asp Phe Trp Ser Ser Ala Leu Gln Ala Lys Ser Ala Gly Val Lys 
225                 230                 235                 240 


Thr Ser Arg Phe Ala Ser Phe Pro Glu Tyr Leu Val Val Gln Ile Lys 
                245                 250                 255     


Lys Phe Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Phe Asp Val Ser 
            260                 265                 270         


Ile Asp Met Pro Asp Leu Leu Asp Ile Asn His Leu Arg Ala Arg Gly 
        275                 280                 285             


Leu Gln Pro Gly Glu Glu Glu Leu Pro Asp Ile Ser Pro Pro Ile Val 
    290                 295                 300                 


Ile Pro Asp Asp Ser Lys Asp Arg Leu Met Asn Gln Leu Ile Asp Pro 
305                 310                 315                 320 


Ser Asp Ile Asp Glu Ser Ser Val Met Gln Leu Ala Glu Met Gly Phe 
                325                 330                 335     


Pro Leu Glu Ala Cys Arg Lys Ala Val Tyr Phe Thr Gly Asn Met Gly 
            340                 345                 350         


Ala Glu Val Ala Phe Asn Trp Ile Ile Val His Met Glu Glu Pro Asp 
        355                 360                 365             


Phe Ala Glu Pro Leu Thr Met Pro Gly Tyr Gly Gly Ala Ala Ser Ala 
    370                 375                 380                 


Gly Ala Ser Val Phe Gly Ala Ser Gly Leu Asp Asn Gln Pro Pro Glu 
385                 390                 395                 400 


Glu Ile Val Ala Ile Ile Thr Ser Met Gly Phe Gln Arg Asn Gln Ala 
                405                 410                 415     


Ile Gln Ala Leu Arg Ala Thr Asn Asn Asn Leu Glu Arg Ala Leu Asp 
            420                 425                 430         


Trp Ile Phe Ser His Pro Glu Phe Glu Glu Asp Ser Asp Phe Val Ile 
        435                 440                 445             


Glu Met Glu Asn Asn Ala Asn Ala Asn Ile Ile Ser Glu Ala Lys Pro 
    450                 455                 460                 


Glu Gly Pro Arg Val Lys Asp Gly Ser Gly Thr Tyr Glu Leu Phe Ala 
465                 470                 475                 480 


Phe Ile Ser His Met Gly Thr Ser Thr Met Ser Gly His Tyr Ile Cys 
                485                 490                 495     


His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr Asn Asp His Lys Val 
            500                 505                 510         


Cys Ala Ser Glu Arg Pro Pro Lys Asp Leu Gly Tyr Met Tyr Phe Tyr 
        515                 520                 525             


Arg Arg Ile Pro Ser 
    530             


<210> 134
<211> 629
<212> PRT
<213> Homo sapiens

<400> 134
Lys Gly Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys 
1               5                   10                  15      


Phe Met Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr 
            20                  25                  30          


Glu Tyr Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn 
        35                  40                  45              


Pro Leu Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val 
    50                  55                  60                  


Lys Gln Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe 
65                  70                  75                  80  


Lys Asn Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln 
                85                  90                  95      


His Asp Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu 
            100                 105                 110         


Asp Leu Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala 
        115                 120                 125             


Ala Gly Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His 
    130                 135                 140                 


Lys Arg Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe 
145                 150                 155                 160 


Lys Ser Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe 
                165                 170                 175     


Asp Pro Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg 
            180                 185                 190         


Val Leu Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu 
        195                 200                 205             


Gln His Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys 
    210                 215                 220                 


Val Ala Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val 
225                 230                 235                 240 


Ala Asp Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu 
                245                 250                 255     


Pro Leu Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val 
            260                 265                 270         


Ser Gly Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val 
        275                 280                 285             


Pro Val Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser 
    290                 295                 300                 


Tyr Tyr Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro 
305                 310                 315                 320 


Arg Asp Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg 
                325                 330                 335     


Leu Ser Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly 
            340                 345                 350         


Asp Glu Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro 
        355                 360                 365             


Ser Thr Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro 
    370                 375                 380                 


Ser Ser Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu 
385                 390                 395                 400 


Gly Thr Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr 
                405                 410                 415     


Leu Gln Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro 
            420                 425                 430         


Glu Glu Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu 
        435                 440                 445             


Met Lys Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys 
    450                 455                 460                 


His Asp Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln 
465                 470                 475                 480 


Glu Cys Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn 
                485                 490                 495     


Pro Trp Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys 
            500                 505                 510         


Leu Asp Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg 
        515                 520                 525             


Phe Ser Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu 
    530                 535                 540                 


Phe Pro Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln 
545                 550                 555                 560 


Asn Glu Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser 
                565                 570                 575     


Asn His Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys 
            580                 585                 590         


Asn Lys Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser 
        595                 600                 605             


Pro Val Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe 
    610                 615                 620                 


Tyr Gln Arg Gln Asp 
625                 


<210> 135
<211> 300
<212> PRT
<213> Homo sapiens

<400> 135
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Cys Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Val Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Ile Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 136
<211> 387
<212> PRT
<213> Homo sapiens

<400> 136
Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu Leu 
            20                  25                  30          


Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly Glu 
        35                  40                  45              


Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe Asp 
    50                  55                  60                  


Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu Gln 
65                  70                  75                  80  


Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln Gly 
                85                  90                  95      


Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met Arg 
            100                 105                 110         


Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys Glu 
        115                 120                 125             


Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys Ser 
    130                 135                 140                 


Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys Cys 
145                 150                 155                 160 


Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln Leu 
                165                 170                 175     


Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr Gly 
            180                 185                 190         


Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr Leu 
        195                 200                 205             


Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu Pro 
    210                 215                 220                 


Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys Glu 
225                 230                 235                 240 


Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met Leu 
                245                 250                 255     


Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val Ser 
            260                 265                 270         


Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln Gln 
        275                 280                 285             


Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys Tyr 
    290                 295                 300                 


Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly Tyr 
305                 310                 315                 320 


Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser Ser 
                325                 330                 335     


Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile Lys 
            340                 345                 350         


Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu Arg 
        355                 360                 365             


Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr Gly 
    370                 375                 380                 


Pro Arg Arg 
385         


<210> 137
<211> 630
<212> PRT
<213> Homo sapiens

<400> 137
Ser His Ile Gln Pro Gly Leu Cys Gly Leu Gly Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Phe Met Asn Ser Ala Leu Gln Cys Leu Ser Asn Thr Ala Pro Leu 
            20                  25                  30          


Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu Ala Glu Ile Asn Arg Asp 
        35                  40                  45              


Asn Pro Leu Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Glu Leu 
    50                  55                  60                  


Ile Lys Gln Met Trp Ser Gly Arg Asp Ala His Val Ala Pro Arg Met 
65                  70                  75                  80  


Phe Lys Thr Gln Val Gly Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln 
                85                  90                  95      


Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His 
            100                 105                 110         


Glu Asp Leu Asn Arg Val Lys Lys Lys Pro Tyr Leu Glu Leu Lys Asp 
        115                 120                 125             


Ala Asn Gly Arg Pro Asp Ala Val Val Ala Lys Glu Ala Trp Glu Asn 
    130                 135                 140                 


His Arg Leu Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu 
145                 150                 155                 160 


Phe Lys Ser Thr Leu Val Cys Pro Glu Cys Ala Lys Val Ser Val Thr 
                165                 170                 175     


Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro Leu Pro Leu Lys Lys Asp 
            180                 185                 190         


Arg Val Met Glu Val Phe Leu Val Pro Ala Asp Pro His Cys Arg Pro 
        195                 200                 205             


Thr Gln Tyr Arg Val Thr Val Pro Leu Met Gly Ala Val Ser Asp Leu 
    210                 215                 220                 


Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile Ala Ala Glu Asn Met Val 
225                 230                 235                 240 


Val Ala Asp Val Tyr Asn His Arg Phe His Lys Ile Phe Gln Met Asp 
                245                 250                 255     


Glu Gly Leu Asn His Ile Met Pro Arg Asp Asp Ile Phe Val Tyr Glu 
            260                 265                 270         


Val Cys Ser Thr Ser Val Asp Gly Ser Glu Cys Val Thr Leu Pro Val 
        275                 280                 285             


Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser Ser Thr Ser Ser Ala Ser 
    290                 295                 300                 


Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser Val Pro Lys His Lys Leu 
305                 310                 315                 320 


Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys Asp Arg Ile Ser Arg Tyr 
                325                 330                 335     


Val Lys Gln Pro Leu Pro Asp Glu Phe Gly Ser Ser Pro Leu Glu Pro 
            340                 345                 350         


Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys Glu Gly Glu Asp Glu Glu 
        355                 360                 365             


Glu Met Glu His Gln Glu Glu Gly Lys Glu Gln Leu Ser Glu Thr Glu 
    370                 375                 380                 


Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp Pro Ser Glu Thr Thr Gln 
385                 390                 395                 400 


Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys Arg Leu Phe Thr Phe Ser 
                405                 410                 415     


Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile Asn Ser Leu Ala Ala Asp 
            420                 425                 430         


Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser Thr Leu Ala Met Asp Trp 
        435                 440                 445             


Asp Ser Glu Thr Arg Arg Leu Tyr Tyr Asp Glu Gln Glu Ser Glu Ala 
    450                 455                 460                 


Tyr Glu Lys His Val Ser Met Leu Gln Pro Gln Lys Lys Lys Lys Thr 
465                 470                 475                 480 


Thr Val Ala Leu Arg Asp Cys Ile Glu Leu Phe Thr Thr Met Glu Thr 
                485                 490                 495     


Leu Gly Glu His Asp Pro Trp Tyr Cys Pro Asn Cys Lys Lys His Gln 
            500                 505                 510         


Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser Leu Pro Lys Ile Leu Val 
        515                 520                 525             


Val His Leu Lys Arg Phe Ser Tyr Asn Arg Tyr Trp Arg Asp Lys Leu 
    530                 535                 540                 


Asp Thr Val Val Glu Phe Pro Ile Arg Gly Leu Asn Met Ser Glu Phe 
545                 550                 555                 560 


Val Cys Asn Leu Ser Ala Arg Pro Tyr Val Tyr Asp Leu Ile Ala Val 
                565                 570                 575     


Ser Asn His Tyr Gly Ala Met Gly Val Gly His Tyr Thr Ala Tyr Ala 
            580                 585                 590         


Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Asn Val 
        595                 600                 605             


Ser Leu Ala Ser Glu Asp Gln Ile Val Thr Lys Ala Ala Tyr Val Leu 
    610                 615                 620                 


Phe Tyr Gln Arg Arg Asp 
625                 630 


<210> 138
<211> 595
<212> PRT
<213> Homo sapiens

<400> 138
Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala Asp Asp Leu 
            20                  25                  30          


Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn Ala Leu Thr 
        35                  40                  45              


Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr Asn Ile Glu 
    50                  55                  60                  


Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile Ser Ala Ala 
65                  70                  75                  80  


Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys Leu Asn Thr 
            100                 105                 110         


Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe Pro Lys Gln 
        115                 120                 125             


Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys Pro Val Ile 
    130                 135                 140                 


Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys Lys Ala Cys 
145                 150                 155                 160 


Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu Ser Ile Asn 
                165                 170                 175     


Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln Ser Thr Phe 
            180                 185                 190         


Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys Ala Lys Cys 
        195                 200                 205             


Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg Leu Pro Arg 
    210                 215                 220                 


Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu Phe Cys Ala 
225                 230                 235                 240 


Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr Leu Lys Val 
                245                 250                 255     


Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro Leu Ser Glu 
            260                 265                 270         


Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile Arg Lys Met 
        275                 280                 285             


Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys Glu Ser Lys 
    290                 295                 300                 


Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser Glu Gln Lys 
305                 310                 315                 320 


Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln Gln Gln Lys 
                325                 330                 335     


Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser Val Tyr Ser 
            340                 345                 350         


Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His Leu Met Thr 
        355                 360                 365             


Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala Gly Gly Lys 
    370                 375                 380                 


Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp Phe Gln Thr 
385                 390                 395                 400 


Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr Ser Lys Phe 
                405                 410                 415     


Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu Tyr Glu Asp 
            420                 425                 430         


Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser Glu Gln Thr 
        435                 440                 445             


Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro Gln Gln Ala 
    450                 455                 460                 


Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His Thr Lys Asn 
465                 470                 475                 480 


Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn Arg Asn Ser 
                485                 490                 495     


Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys Asp Ile Leu 
            500                 505                 510         


Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn Asp Asp Lys 
        515                 520                 525             


Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His Leu Gly Lys 
    530                 535                 540                 


Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp Phe Glu Lys 
545                 550                 555                 560 


Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly Ile Gln Glu 
                565                 570                 575     


Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile Phe Phe Tyr 
            580                 585                 590         


Met His Asn 
        595 


<210> 139
<211> 723
<212> PRT
<213> Homo sapiens

<400> 139
Leu Pro Gly Phe Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Val Ile Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe 
            20                  25                  30          


Phe His Asp Arg Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu 
        35                  40                  45              


Gly Thr Gly Gly Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala 
    50                  55                  60                  


Leu Trp Lys Gly Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala 
65                  70                  75                  80  


Ile Val Ala Ser Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp 
                85                  90                  95      


Ala Gln Glu Phe Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu 
            100                 105                 110         


Asn Arg Ile Gln Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly 
        115                 120                 125             


Arg Pro Asp Glu Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met 
    130                 135                 140                 


Arg Asn Asp Ser Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser 
145                 150                 155                 160 


Lys Leu Val Cys Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro 
                165                 170                 175     


Phe Leu Tyr Leu Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro 
            180                 185                 190         


Val Phe Tyr Phe Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu 
        195                 200                 205             


Val Ser Val Ser Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser 
    210                 215                 220                 


Leu Ser Gln Ser Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu 
225                 230                 235                 240 


Val Ile Lys Asn Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu 
                245                 250                 255     


Asp Thr Val Ser Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser 
            260                 265                 270         


Ser Glu Leu Ala Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg 
        275                 280                 285             


Pro Gln Val Pro Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg 
    290                 295                 300                 


Lys Gln Gln Ser Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr 
305                 310                 315                 320 


Arg Val Gly Tyr Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp 
                325                 330                 335     


His Lys Gly Leu Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ala Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu 
        355                 360                 365             


Glu Gly Tyr Ala Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln 
    370                 375                 380                 


Pro Gly Arg Met Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu 
385                 390                 395                 400 


Leu Ser Thr Gly Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile 
                405                 410                 415     


Gln Pro Pro Glu Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr 
            420                 425                 430         


Gly Leu Pro Arg Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser 
        435                 440                 445             


Thr Ser Gly Ile Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val 
    450                 455                 460                 


Gly Ser Leu Pro Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val 
465                 470                 475                 480 


Pro Gly Tyr Gln His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln 
                485                 490                 495     


Phe Phe Ile Tyr Lys Ile Asp Ser Ser Asn Arg Glu Gln Arg Leu Glu 
            500                 505                 510         


Asp Lys Gly Asp Thr Pro Leu Glu Leu Gly Asp Asp Cys Ser Leu Ala 
        515                 520                 525             


Leu Val Trp Arg Asn Asn Glu Arg Leu Gln Glu Phe Val Leu Val Ala 
    530                 535                 540                 


Ser Lys Glu Leu Glu Cys Ala Glu Asp Pro Gly Ser Ala Gly Glu Ala 
545                 550                 555                 560 


Ala Arg Ala Gly His Phe Thr Leu Asp Gln Cys Leu Asn Leu Phe Thr 
                565                 570                 575     


Arg Pro Glu Val Leu Ala Pro Glu Glu Ala Trp Tyr Cys Pro Gln Cys 
            580                 585                 590         


Lys Gln His Arg Glu Ala Ser Lys Gln Leu Leu Leu Trp Arg Leu Pro 
        595                 600                 605             


Asn Val Leu Ile Val Gln Leu Lys Arg Phe Ser Phe Arg Ser Phe Ile 
    610                 615                 620                 


Trp Arg Asp Lys Ile Asn Asp Leu Val Glu Phe Pro Val Arg Asn Leu 
625                 630                 635                 640 


Asp Leu Ser Lys Phe Cys Ile Gly Gln Lys Glu Glu Gln Leu Pro Ser 
                645                 650                 655     


Tyr Asp Leu Tyr Ala Val Ile Asn His Tyr Gly Gly Met Ile Gly Gly 
            660                 665                 670         


His Tyr Thr Ala Cys Ala Arg Leu Pro Asn Asp Arg Ser Ser Gln Arg 
        675                 680                 685             


Ser Asp Val Gly Trp Arg Leu Phe Asp Asp Ser Thr Val Thr Thr Val 
    690                 695                 700                 


Asp Glu Ser Gln Val Val Thr Arg Tyr Ala Tyr Val Leu Phe Tyr Arg 
705                 710                 715                 720 


Arg Arg Asn 
            


<210> 140
<211> 386
<212> PRT
<213> Homo sapiens

<400> 140
Ser Leu Gln Pro Arg Gly Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile 
1               5                   10                  15      


Asn Ala Thr Leu Gln Ala Leu Val Ala Cys Pro Pro Met Tyr His Leu 
            20                  25                  30          


Met Lys Phe Ile Pro Leu Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser 
        35                  40                  45              


Thr Pro Met Ile Asp Ser Phe Val Arg Leu Met Asn Glu Phe Thr Asn 
    50                  55                  60                  


Met Pro Val Pro Pro Lys Pro Arg Gln Ala Leu Gly Asp Lys Ile Val 
65                  70                  75                  80  


Arg Asp Ile Arg Pro Gly Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg 
                85                  90                  95      


Leu Leu Thr Val Asn Lys Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu 
            100                 105                 110         


Asp Ala Glu Glu Tyr Leu Gly Phe Ile Leu Asn Gly Leu His Glu Glu 
        115                 120                 125             


Met Leu Asn Leu Lys Lys Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr 
    130                 135                 140                 


Ile Ser Asn Gly Pro Lys Asn His Ser Val Asn Glu Glu Glu Gln Glu 
145                 150                 155                 160 


Glu Gln Gly Glu Gly Ser Glu Asp Glu Trp Glu Gln Val Gly Pro Arg 
                165                 170                 175     


Asn Lys Thr Ser Val Thr Arg Gln Ala Asp Phe Val Gln Thr Pro Ile 
            180                 185                 190         


Thr Gly Ile Phe Gly Gly His Ile Arg Ser Val Val Tyr Gln Gln Ser 
        195                 200                 205             


Ser Lys Glu Ser Ala Thr Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp 
    210                 215                 220                 


Ile Gln Ser Asp Lys Ile Arg Thr Val Gln Asp Ala Leu Glu Ser Leu 
225                 230                 235                 240 


Val Ala Arg Glu Ser Val Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu 
                245                 250                 255     


Val Glu Ile Ser Arg Arg Val Thr Leu Glu Lys Leu Pro Pro Val Leu 
            260                 265                 270         


Val Leu His Leu Lys Arg Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln 
        275                 280                 285             


Lys Leu Ile Lys Asn Ile Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys 
    290                 295                 300                 


Glu Leu Leu Ser Pro Gly Val Lys Asn Lys Asn Phe Lys Cys His Arg 
305                 310                 315                 320 


Thr Tyr Arg Leu Phe Ala Val Val Tyr His His Gly Asn Ser Ala Thr 
                325                 330                 335     


Gly Gly His Tyr Thr Thr Asp Val Phe Gln Ile Gly Leu Asn Gly Trp 
            340                 345                 350         


Leu Arg Ile Asp Asp Gln Thr Val Lys Val Ile Asn Gln Tyr Gln Val 
        355                 360                 365             


Val Lys Pro Thr Ala Glu Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg 
    370                 375                 380                 


Val Asp 
385     


<210> 141
<211> 658
<212> PRT
<213> Homo sapiens

<400> 141
Met Asp Arg Cys Lys His Val Gly Arg Leu Arg Leu Ala Gln Asp His 
1               5                   10                  15      


Ser Ile Leu Asn Pro Gln Lys Trp Cys Cys Leu Glu Cys Ala Thr Thr 
            20                  25                  30          


Glu Ser Val Trp Ala Cys Leu Lys Cys Ser His Val Ala Cys Gly Arg 
        35                  40                  45              


Tyr Ile Glu Asp His Ala Leu Lys His Phe Glu Glu Thr Gly His Pro 
    50                  55                  60                  


Leu Ala Met Glu Val Arg Asp Leu Tyr Val Phe Cys Tyr Leu Cys Lys 
65                  70                  75                  80  


Asp Tyr Val Leu Asn Asp Asn Pro Glu Gly Asp Leu Lys Leu Leu Arg 
                85                  90                  95      


Ser Ser Leu Leu Ala Val Arg Gly Gln Lys Gln Asp Thr Pro Val Arg 
            100                 105                 110         


Arg Gly Arg Thr Leu Arg Ser Met Ala Ser Gly Glu Asp Val Val Leu 
        115                 120                 125             


Pro Gln Arg Ala Pro Gln Gly Gln Pro Gln Met Leu Thr Ala Leu Trp 
    130                 135                 140                 


Tyr Arg Arg Gln Arg Leu Leu Ala Arg Thr Leu Arg Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ser Ser Arg Gly Gln Ala Lys Leu Glu Gln Arg Arg Gln Glu Glu 
                165                 170                 175     


Ala Leu Glu Arg Lys Lys Glu Glu Ala Arg Arg Arg Arg Arg Glu Val 
            180                 185                 190         


Lys Arg Arg Leu Leu Glu Glu Leu Ala Ser Thr Pro Pro Arg Lys Ser 
        195                 200                 205             


Ala Arg Leu Leu Leu His Thr Pro Arg Asp Ala Gly Pro Ala Ala Ser 
    210                 215                 220                 


Arg Pro Ala Ala Leu Pro Thr Ser Arg Arg Val Pro Ala Ala Thr Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Gln Pro Ala Met Ala Pro Gly Val Thr Gly Leu Arg 
                245                 250                 255     


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Ile Leu Gln Val Leu Ser 
            260                 265                 270         


His Leu Gln Lys Phe Arg Glu Cys Phe Leu Asn Leu Asp Pro Ser Lys 
        275                 280                 285             


Thr Glu His Leu Phe Pro Lys Ala Thr Asn Gly Lys Thr Gln Leu Ser 
    290                 295                 300                 


Gly Lys Pro Thr Asn Ser Ser Ala Thr Glu Leu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Arg Ala Glu Ala Cys Glu Arg Glu Gly Phe Cys Trp Asn Gly Arg Ala 
                325                 330                 335     


Ser Ile Ser Arg Ser Leu Glu Leu Ile Gln Asn Lys Glu Pro Ser Ser 
            340                 345                 350         


Lys His Ile Ser Leu Cys Arg Glu Leu His Thr Leu Phe Arg Val Met 
        355                 360                 365             


Trp Ser Gly Lys Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser 
    370                 375                 380                 


Val Trp Ser Leu Ile Pro Ala Phe Arg Gly Tyr Asp Gln Gln Asp Ala 
385                 390                 395                 400 


Gln Glu Phe Leu Cys Glu Leu Leu His Lys Val Gln Gln Glu Leu Glu 
                405                 410                 415     


Ser Glu Gly Thr Thr Arg Arg Ile Leu Ile Pro Phe Ser Gln Arg Lys 
            420                 425                 430         


Leu Thr Lys Gln Val Leu Lys Val Val Asn Thr Ile Phe His Gly Gln 
        435                 440                 445             


Leu Leu Ser Gln Val Thr Cys Ile Ser Cys Asn Tyr Lys Ser Asn Thr 
    450                 455                 460                 


Ile Glu Pro Phe Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr His 
465                 470                 475                 480 


Cys Ile Glu Lys Gly Phe Val Pro Leu Asn Gln Thr Glu Cys Leu Leu 
                485                 490                 495     


Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu Ala Leu Glu Gly Arg 
            500                 505                 510         


Ile Tyr Ala Cys Asp Gln Cys Asn Ser Lys Arg Arg Lys Ser Asn Pro 
        515                 520                 525             


Lys Pro Leu Val Leu Ser Glu Ala Arg Lys Gln Leu Met Ile Tyr Arg 
    530                 535                 540                 


Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg Phe Arg Trp Ser Gly 
545                 550                 555                 560 


Arg Asn His Arg Glu Lys Ile Gly Val His Val Val Phe Asp Gln Val 
                565                 570                 575     


Leu Thr Met Glu Pro Tyr Cys Cys Arg Asp Met Leu Ser Ser Leu Asp 
            580                 585                 590         


Lys Glu Thr Phe Ala Tyr Asp Leu Ser Ala Val Val Met His His Gly 
        595                 600                 605             


Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr Cys Tyr Asn Thr Glu 
    610                 615                 620                 


Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys Leu Asn Val Cys Ser 
625                 630                 635                 640 


Val Glu Glu Val Cys Lys Thr Gln Ala Tyr Ile Leu Phe Tyr Thr Gln 
                645                 650                 655     


Arg Thr 
        


<210> 142
<211> 300
<212> PRT
<213> Homo sapiens

<400> 142
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Leu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


Pro Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Cys 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly Tyr Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 143
<211> 311
<212> PRT
<213> Homo sapiens

<400> 143
Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys Ala Val 
            20                  25                  30          


Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val Pro Leu 
        35                  40                  45              


Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys Pro Val 
    50                  55                  60                  


Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu Asp Ser 
65                  70                  75                  80  


Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu Asp Asn 
                85                  90                  95      


Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile Pro Lys 
            100                 105                 110         


Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu Val Asp 
        115                 120                 125             


Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu Ser Ile 
    130                 135                 140                 


Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val Ala Val 
145                 150                 155                 160 


Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His Gly Leu 
                165                 170                 175     


Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro Val Leu 
            180                 185                 190         


His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp Gln Asn 
        195                 200                 205             


Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro Leu Asp 
    210                 215                 220                 


Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr Ile Leu 
225                 230                 235                 240 


His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His Tyr Val 
                245                 250                 255     


Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe Asp Asp 
            260                 265                 270         


Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His Asn Tyr 
        275                 280                 285             


Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn Ala Tyr 
    290                 295                 300                 


Met Leu Val Tyr Ile Arg Glu 
305                 310     


<210> 144
<211> 338
<212> PRT
<213> Homo sapiens

<400> 144
Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp Tyr 
            20                  25                  30          


Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn Ala 
        35                  40                  45              


His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile Trp 
    50                  55                  60                  


Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr Gln 
65                  70                  75                  80  


Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val Asn 
            100                 105                 110         


Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His Leu 
        115                 120                 125             


Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu Arg 
    130                 135                 140                 


Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro Phe 
                165                 170                 175     


Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val Thr 
            180                 185                 190         


Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp Gly 
        195                 200                 205             


Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys Ile 
    210                 215                 220                 


Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His Leu 
225                 230                 235                 240 


Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr Phe 
                245                 250                 255     


Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser Glu 
            260                 265                 270         


Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His Ser 
        275                 280                 285             


Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro Gly 
    290                 295                 300                 


Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met Ser 
305                 310                 315                 320 


Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu Leu 
                325                 330                 335     


Ala Ser 
        


<210> 145
<211> 363
<212> PRT
<213> Homo sapiens

<400> 145
Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu Asp 
            20                  25                  30          


Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser 
        35                  40                  45              


Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg Ile 
    50                  55                  60                  


Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile Leu 
65                  70                  75                  80  


Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro 
                85                  90                  95      


Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu Pro 
            100                 105                 110         


Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe 
        115                 120                 125             


Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr Ile 
    130                 135                 140                 


Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala 
145                 150                 155                 160 


Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys Asp 
                165                 170                 175     


Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr 
            180                 185                 190         


Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu 
        195                 200                 205             


Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala 
    210                 215                 220                 


Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr Gln Val His Leu 
225                 230                 235                 240 


His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro Lys 
                245                 250                 255     


Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln Asn 
            260                 265                 270         


Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val Ala 
        275                 280                 285             


Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser 
    290                 295                 300                 


Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln Val 
305                 310                 315                 320 


Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp 
                325                 330                 335     


Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu 
            340                 345                 350         


Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser 
        355                 360             


<210> 146
<211> 300
<212> PRT
<213> Homo sapiens

<400> 146
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 147
<211> 341
<212> PRT
<213> Homo sapiens

<400> 147
Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His 
1               5                   10                  15      


Thr Pro Leu Leu Arg Asp Phe Phe Leu Ser Asp Arg His Arg Cys Glu 
            20                  25                  30          


Met Gln Ser Pro Ser Ser Cys Leu Val Cys Glu Met Ser Ser Leu Phe 
        35                  40                  45              


Gln Glu Phe Tyr Ser Gly His Arg Ser Pro His Ile Pro Tyr Lys Leu 
    50                  55                  60                  


Leu His Leu Val Trp Thr His Ala Arg His Leu Ala Gly Tyr Glu Gln 
65                  70                  75                  80  


Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp Val Leu His Arg 
                85                  90                  95      


His Cys Lys Gly Asp Asp Asn Gly Lys Lys Ala Asn Asn Pro Asn His 
            100                 105                 110         


Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp 
        115                 120                 125             


Val Thr Cys Gln Val Cys His Gly Val Ser Thr Thr Ile Asp Pro Phe 
    130                 135                 140                 


Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Ser Thr Pro Phe Trp Pro 
145                 150                 155                 160 


Leu Ser Pro Gly Ser Glu Gly Asn Val Val Asn Gly Glu Ser His Val 
                165                 170                 175     


Ser Gly Thr Thr Thr Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg Pro 
            180                 185                 190         


Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Ser Gly Cys His Ser 
        195                 200                 205             


Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile Val 
    210                 215                 220                 


Ala Cys Phe His Leu Lys Arg Phe Glu His Ser Ala Lys Leu Arg Arg 
225                 230                 235                 240 


Lys Ile Thr Thr Tyr Val Ser Phe Pro Leu Glu Leu Asp Met Thr Pro 
                245                 250                 255     


Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly Gln Tyr Gln Gln 
            260                 265                 270         


Pro Thr Asp Ser Leu Asn Asn Asp Asn Lys Tyr Ser Leu Phe Ala Val 
        275                 280                 285             


Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile 
    290                 295                 300                 


Arg Gln His Lys Asp Gln Trp Phe Lys Cys Asp Asp Ala Ile Ile Thr 
305                 310                 315                 320 


Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu Phe 
                325                 330                 335     


Tyr His Lys Gln Phe 
            340     


<210> 148
<211> 440
<212> PRT
<213> Homo sapiens

<400> 148
Lys Gly Leu Val Pro Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Leu Leu Gln Gly Leu Ser Ala Cys Pro Ala Phe Ile Arg Trp 
            20                  25                  30          


Leu Glu Glu Phe Thr Ser Gln Tyr Ser Arg Asp Gln Lys Glu Pro Pro 
        35                  40                  45              


Ser His Gln Tyr Leu Ser Leu Thr Leu Leu His Leu Leu Lys Ala Leu 
    50                  55                  60                  


Ser Cys Gln Glu Val Thr Asp Asp Glu Val Leu Asp Ala Ser Cys Leu 
65                  70                  75                  80  


Leu Asp Val Leu Arg Met Tyr Arg Trp Gln Ile Ser Ser Phe Glu Glu 
                85                  90                  95      


Gln Asp Ala His Glu Leu Phe His Val Ile Thr Ser Ser Leu Glu Asp 
            100                 105                 110         


Glu Arg Asp Arg Gln Pro Arg Val Thr His Leu Phe Asp Val His Ser 
        115                 120                 125             


Leu Glu Gln Gln Ser Glu Ile Thr Pro Lys Gln Ile Thr Cys Arg Thr 
    130                 135                 140                 


Arg Gly Ser Pro His Pro Thr Ser Asn His Trp Lys Ser Gln His Pro 
145                 150                 155                 160 


Phe His Gly Arg Leu Thr Ser Asn Met Val Cys Lys His Cys Glu His 
                165                 170                 175     


Gln Ser Pro Val Arg Phe Asp Thr Phe Asp Ser Leu Ser Leu Ser Ile 
            180                 185                 190         


Pro Ala Ala Thr Trp Gly His Pro Leu Thr Leu Asp His Cys Leu His 
        195                 200                 205             


His Phe Ile Ser Ser Glu Ser Val Arg Asp Val Val Cys Asp Asn Cys 
    210                 215                 220                 


Thr Lys Ile Glu Ala Lys Gly Thr Leu Asn Gly Glu Lys Val Glu His 
225                 230                 235                 240 


Gln Arg Thr Thr Phe Val Lys Gln Leu Lys Leu Gly Lys Leu Pro Gln 
                245                 250                 255     


Cys Leu Cys Ile His Leu Gln Arg Leu Ser Trp Ser Ser His Gly Thr 
            260                 265                 270         


Pro Leu Lys Arg His Glu His Val Gln Phe Asn Glu Phe Leu Met Met 
        275                 280                 285             


Asp Ile Tyr Lys Tyr His Leu Leu Gly His Lys Pro Ser Gln His Asn 
    290                 295                 300                 


Pro Lys Leu Asn Lys Asn Pro Gly Pro Thr Leu Glu Leu Gln Asp Gly 
305                 310                 315                 320 


Pro Gly Ala Pro Thr Pro Val Leu Asn Gln Pro Gly Ala Pro Lys Thr 
                325                 330                 335     


Gln Ile Phe Met Asn Gly Ala Cys Ser Pro Ser Leu Leu Pro Thr Leu 
            340                 345                 350         


Ser Ala Pro Met Pro Phe Pro Leu Pro Val Val Pro Asp Tyr Ser Ser 
        355                 360                 365             


Ser Thr Tyr Leu Phe Arg Leu Met Ala Val Val Val His His Gly Asp 
    370                 375                 380                 


Met His Ser Gly His Phe Val Thr Tyr Arg Arg Ser Pro Pro Ser Ala 
385                 390                 395                 400 


Arg Asn Pro Leu Ser Thr Ser Asn Gln Trp Leu Trp Val Ser Asp Asp 
                405                 410                 415     


Thr Val Arg Lys Ala Ser Leu Gln Glu Val Leu Ser Ser Ser Ala Tyr 
            420                 425                 430         


Leu Leu Phe Tyr Glu Arg Val Leu 
        435                 440 


<210> 149
<211> 496
<212> PRT
<213> Homo sapiens

<400> 149
Gly Trp Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser 
1               5                   10                  15      


Ala Val Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val 
            20                  25                  30          


Leu Ser Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His 
        35                  40                  45              


Thr Glu Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe 
    50                  55                  60                  


Ala Leu Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala 
65                  70                  75                  80  


Leu Asp Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln 
                85                  90                  95      


Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala 
            100                 105                 110         


Phe Gln Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn 
        115                 120                 125             


Pro Met Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg 
    130                 135                 140                 


Glu Gly Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu 
145                 150                 155                 160 


Gln Val Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met 
                165                 170                 175     


Val Glu Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr 
            180                 185                 190         


Gly Gln Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu 
        195                 200                 205             


Leu Ser Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile 
    210                 215                 220                 


His Asn Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met 
225                 230                 235                 240 


Tyr Arg Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys 
                245                 250                 255     


Leu Lys Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val 
            260                 265                 270         


Lys Tyr Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys 
        275                 280                 285             


Tyr Val Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro 
    290                 295                 300                 


Pro Glu Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys 
305                 310                 315                 320 


Ser Val Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser 
                325                 330                 335     


Ser Gln Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro 
            340                 345                 350         


Lys Ser Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser 
        355                 360                 365             


Gln Pro Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys 
    370                 375                 380                 


Thr Cys Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp 
385                 390                 395                 400 


Leu Lys Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr 
                405                 410                 415     


Cys Asp Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu 
            420                 425                 430         


Val His Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr 
        435                 440                 445             


Asn Gln Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr 
    450                 455                 460                 


Glu Ser Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg 
465                 470                 475                 480 


Asn Val Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr 
                485                 490                 495     


<210> 150
<211> 300
<212> PRT
<213> Homo sapiens

<400> 150
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Lys Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 151
<211> 644
<212> PRT
<213> Homo sapiens

<400> 151
Pro Val Pro Gly Val Ala Gly Leu Arg Asn His Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Thr Leu Gln Cys Leu Ser Asn Thr Glu Leu Phe Ala Glu 
            20                  25                  30          


Tyr Leu Ala Leu Gly Gln Tyr Arg Ala Gly Arg Pro Glu Pro Ser Pro 
        35                  40                  45              


Asp Pro Glu Gln Pro Ala Gly Arg Gly Ala Gln Gly Gln Gly Glu Val 
    50                  55                  60                  


Thr Glu Gln Leu Ala His Leu Val Arg Ala Leu Trp Thr Leu Glu Tyr 
65                  70                  75                  80  


Thr Pro Gln His Ser Arg Asp Phe Lys Thr Ile Val Ser Lys Asn Ala 
                85                  90                  95      


Leu Gln Tyr Arg Gly Asn Ser Gln His Asp Ala Gln Glu Phe Leu Leu 
            100                 105                 110         


Trp Leu Leu Asp Arg Val His Glu Asp Leu Asn His Ser Val Lys Gln 
        115                 120                 125             


Ser Gly Gln Pro Pro Leu Lys Pro Pro Ser Glu Thr Asp Met Met Pro 
    130                 135                 140                 


Glu Gly Pro Ser Phe Pro Val Cys Ser Thr Phe Val Gln Glu Leu Phe 
145                 150                 155                 160 


Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys Gln Lys Gln 
                165                 170                 175     


Ser Asn Thr Phe Asp Pro Phe Leu Cys Ile Ser Leu Pro Ile Pro Leu 
            180                 185                 190         


Pro His Thr Arg Pro Leu Tyr Val Thr Val Val Tyr Gln Gly Lys Cys 
        195                 200                 205             


Ser His Cys Met Arg Ile Gly Val Ala Val Pro Leu Ser Gly Thr Val 
    210                 215                 220                 


Ala Arg Leu Arg Glu Ala Val Ser Met Glu Thr Lys Ile Pro Thr Asp 
225                 230                 235                 240 


Gln Ile Val Leu Thr Glu Met Tyr Tyr Asp Gly Phe His Arg Ser Phe 
                245                 250                 255     


Cys Asp Thr Asp Asp Leu Glu Thr Val His Glu Ser Asp Cys Ile Phe 
            260                 265                 270         


Ala Phe Glu Thr Pro Glu Ile Phe Arg Pro Glu Gly Ile Leu Ser Gln 
        275                 280                 285             


Arg Gly Ile His Leu Asn Asn Asn Leu Asn His Leu Lys Phe Gly Leu 
    290                 295                 300                 


Asp Tyr His Arg Leu Ser Ser Pro Thr Gln Thr Ala Ala Lys Gln Gly 
305                 310                 315                 320 


Lys Met Asp Ser Pro Thr Ser Arg Ala Gly Ser Asp Lys Ile Val Leu 
                325                 330                 335     


Leu Val Cys Asn Arg Ala Cys Thr Gly Gln Gln Gly Lys Arg Phe Gly 
            340                 345                 350         


Leu Pro Phe Val Leu His Leu Glu Lys Thr Ile Ala Trp Asp Leu Leu 
        355                 360                 365             


Gln Lys Glu Ile Leu Glu Lys Met Lys Tyr Phe Leu Arg Pro Thr Val 
    370                 375                 380                 


Cys Ile Gln Val Cys Pro Phe Ser Leu Arg Val Val Ser Val Val Gly 
385                 390                 395                 400 


Ile Thr Tyr Leu Leu Pro Gln Glu Glu Gln Pro Leu Cys His Pro Ile 
                405                 410                 415     


Val Glu Arg Ala Leu Lys Ser Cys Gly Pro Gly Gly Thr Ala His Val 
            420                 425                 430         


Lys Leu Val Val Glu Trp Asp Lys Glu Thr Arg Asp Phe Leu Phe Val 
        435                 440                 445             


Asn Thr Glu Asp Glu Tyr Ile Pro Asp Ala Glu Ser Val Arg Leu Gln 
    450                 455                 460                 


Arg Glu Arg His His Gln Pro Gln Thr Cys Thr Leu Ser Gln Cys Phe 
465                 470                 475                 480 


Gln Leu Tyr Thr Lys Glu Glu Arg Leu Ala Pro Asp Asp Ala Trp Arg 
                485                 490                 495     


Cys Pro His Cys Lys Gln Leu Gln Gln Gly Ser Ile Thr Leu Ser Leu 
            500                 505                 510         


Trp Thr Leu Pro Asp Val Leu Ile Ile His Leu Lys Arg Phe Arg Gln 
        515                 520                 525             


Glu Gly Asp Arg Arg Met Lys Leu Gln Asn Met Val Lys Phe Pro Leu 
    530                 535                 540                 


Thr Gly Leu Asp Met Thr Pro His Val Val Lys Arg Ser Gln Ser Ser 
545                 550                 555                 560 


Trp Ser Leu Pro Ser His Trp Ser Pro Trp Arg Arg Pro Tyr Gly Leu 
                565                 570                 575     


Gly Arg Asp Pro Glu Asp Tyr Ile Tyr Asp Leu Tyr Ala Val Cys Asn 
            580                 585                 590         


His His Gly Thr Met Gln Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn 
        595                 600                 605             


Ser Val Asp Gly Leu Trp Tyr Cys Phe Asp Asp Ser Asp Val Gln Gln 
    610                 615                 620                 


Leu Ser Glu Asp Glu Val Cys Thr Gln Thr Ala Tyr Ile Leu Phe Tyr 
625                 630                 635                 640 


Gln Arg Arg Thr 
                


<210> 152
<211> 344
<212> PRT
<213> Homo sapiens

<400> 152
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 153
<211> 300
<212> PRT
<213> Homo sapiens

<400> 153
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Asp Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Lys Leu Tyr Met Ser Gln Thr Asn Ser Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 154
<211> 382
<212> PRT
<213> Homo sapiens

<400> 154
Glu Thr Gly Tyr Val Gly Leu Val Asn Gln Ala Met Thr Cys Tyr Leu 
1               5                   10                  15      


Asn Ser Leu Leu Gln Thr Leu Phe Met Thr Pro Glu Phe Arg Asn Ala 
            20                  25                  30          


Leu Tyr Lys Trp Glu Phe Glu Glu Ser Glu Glu Asp Pro Val Thr Ser 
        35                  40                  45              


Ile Pro Tyr Gln Leu Gln Arg Leu Phe Val Leu Leu Gln Thr Ser Lys 
    50                  55                  60                  


Lys Arg Ala Ile Glu Thr Thr Asp Val Thr Arg Ser Phe Gly Trp Asp 
65                  70                  75                  80  


Ser Ser Glu Ala Trp Gln Gln His Asp Val Gln Glu Leu Cys Arg Val 
                85                  90                  95      


Met Phe Asp Ala Leu Glu Gln Lys Trp Lys Gln Thr Glu Gln Ala Asp 
            100                 105                 110         


Leu Ile Asn Glu Leu Tyr Gln Gly Lys Leu Lys Asp Tyr Val Arg Cys 
        115                 120                 125             


Leu Glu Cys Gly Tyr Glu Gly Trp Arg Ile Asp Thr Tyr Leu Asp Ile 
    130                 135                 140                 


Pro Leu Val Ile Arg Pro Tyr Gly Ser Ser Gln Ala Phe Ala Ser Val 
145                 150                 155                 160 


Glu Glu Ala Leu His Ala Phe Ile Gln Pro Glu Ile Leu Asp Gly Pro 
                165                 170                 175     


Asn Gln Tyr Phe Cys Glu Arg Cys Lys Lys Lys Cys Asp Ala Arg Lys 
            180                 185                 190         


Gly Leu Arg Phe Leu His Phe Pro Tyr Leu Leu Thr Leu Gln Leu Lys 
        195                 200                 205             


Arg Phe Asp Phe Asp Tyr Thr Thr Met His Arg Ile Lys Leu Asn Asp 
    210                 215                 220                 


Arg Met Thr Phe Pro Glu Glu Leu Asp Met Ser Thr Phe Ile Asp Val 
225                 230                 235                 240 


Glu Asp Glu Lys Ser Pro Gln Thr Glu Ser Cys Thr Asp Ser Gly Ala 
                245                 250                 255     


Glu Asn Glu Gly Ser Cys His Ser Asp Gln Met Ser Asn Asp Phe Ser 
            260                 265                 270         


Asn Asp Asp Gly Val Asp Glu Gly Ile Cys Leu Glu Thr Asn Ser Gly 
        275                 280                 285             


Thr Glu Lys Ile Ser Lys Ser Gly Leu Glu Lys Asn Ser Leu Ile Tyr 
    290                 295                 300                 


Glu Leu Phe Ser Val Met Val His Ser Gly Ser Ala Ala Gly Gly His 
305                 310                 315                 320 


Tyr Tyr Ala Cys Ile Lys Ser Phe Ser Asp Glu Gln Trp Tyr Ser Phe 
                325                 330                 335     


Asn Asp Gln His Val Ser Arg Ile Thr Gln Glu Asp Ile Lys Lys Thr 
            340                 345                 350         


His Gly Gly Ser Ser Gly Ser Arg Gly Tyr Tyr Ser Ser Ala Phe Ala 
        355                 360                 365             


Ser Ser Thr Asn Ala Tyr Met Leu Ile Tyr Arg Leu Lys Asp 
    370                 375                 380         


<210> 155
<211> 350
<212> PRT
<213> Homo sapiens

<400> 155
Tyr Thr Val Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Cys Ile Val Gln Ala Leu Thr His Ile Pro Leu Leu Lys Asp 
            20                  25                  30          


Phe Phe Leu Ser Asp Lys His Lys Cys Ile Met Thr Ser Pro Ser Leu 
        35                  40                  45              


Cys Leu Val Cys Glu Met Ser Ser Leu Phe His Ala Met Tyr Ser Gly 
    50                  55                  60                  


Ser Arg Thr Pro His Ile Pro Tyr Lys Leu Leu His Leu Ile Trp Ile 
65                  70                  75                  80  


His Ala Glu His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His Glu Phe 
                85                  90                  95      


Leu Ile Ala Ile Leu Asp Val Leu His Arg His Ser Lys Asp Asp Ser 
            100                 105                 110         


Gly Gly Gln Glu Ala Asn Asn Pro Asn Cys Cys Asn Cys Ile Ile Asp 
        115                 120                 125             


Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln Ala Cys 
    130                 135                 140                 


His Ser Val Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser Leu Asp 
145                 150                 155                 160 


Leu Pro Gly Ser Cys Ala Thr Phe Asp Ser Gln Asn Pro Glu Arg Ala 
                165                 170                 175     


Asp Ser Thr Val Ser Arg Asp Asp His Ile Pro Gly Ile Pro Ser Leu 
            180                 185                 190         


Thr Asp Cys Leu Gln Trp Phe Thr Arg Pro Glu His Leu Gly Ser Ser 
        195                 200                 205             


Ala Lys Ile Lys Cys Asn Ser Cys Gln Ser Tyr Gln Glu Ser Thr Lys 
    210                 215                 220                 


Gln Leu Thr Met Lys Lys Leu Pro Ile Val Ala Cys Phe His Leu Lys 
225                 230                 235                 240 


Arg Phe Glu His Val Gly Lys Gln Arg Arg Lys Ile Asn Thr Phe Ile 
                245                 250                 255     


Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe Leu Ala Ser Thr Lys 
            260                 265                 270         


Glu Ser Arg Met Lys Glu Gly Gln Pro Pro Thr Asp Cys Val Pro Asn 
        275                 280                 285             


Glu Asn Lys Tyr Ser Leu Phe Ala Val Ile Asn His His Gly Thr Leu 
    290                 295                 300                 


Glu Ser Gly His Tyr Thr Ser Phe Ile Arg Gln Gln Lys Asp Gln Trp 
305                 310                 315                 320 


Phe Ser Cys Asp Asp Ala Ile Ile Thr Lys Ala Thr Ile Glu Asp Leu 
                325                 330                 335     


Leu Tyr Ser Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Gly 
            340                 345                 350 


<210> 156
<211> 306
<212> PRT
<213> Homo sapiens

<400> 156
Arg Val Gly Ala Gly Leu His Asn Leu Gly Asn Thr Cys Phe Leu Asn 
1               5                   10                  15      


Ala Thr Ile Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Leu 
            20                  25                  30          


Leu Ser Lys Glu His Ala Arg Ser Cys His Gln Gly Ser Phe Cys Met 
        35                  40                  45              


Leu Cys Val Met Gln Asn His Ile Val Gln Ala Phe Ala Asn Ser Gly 
    50                  55                  60                  


Asn Ala Ile Lys Pro Val Ser Phe Ile Arg Asp Leu Lys Lys Ile Ala 
65                  70                  75                  80  


Arg His Phe Arg Phe Gly Asn Gln Glu Asp Ala His Glu Phe Leu Arg 
                85                  90                  95      


Tyr Thr Ile Asp Ala Met Gln Lys Ala Cys Leu Asn Gly Cys Ala Lys 
            100                 105                 110         


Leu Asp Arg Gln Thr Gln Ala Thr Thr Leu Val His Gln Ile Phe Gly 
        115                 120                 125             


Gly Tyr Leu Arg Ser Arg Val Lys Cys Ser Val Cys Lys Ser Val Ser 
    130                 135                 140                 


Asp Thr Tyr Asp Pro Tyr Leu Asp Val Ala Leu Glu Ile Arg Gln Ala 
145                 150                 155                 160 


Ala Asn Ile Val Arg Ala Leu Glu Leu Phe Val Lys Ala Asp Val Leu 
                165                 170                 175     


Ser Gly Glu Asn Ala Tyr Met Cys Ala Lys Cys Lys Lys Lys Val Pro 
            180                 185                 190         


Ala Ser Lys Arg Phe Thr Ile His Arg Thr Ser Asn Val Leu Thr Leu 
        195                 200                 205             


Ser Leu Lys Arg Phe Ala Asn Phe Ser Gly Gly Lys Ile Thr Lys Asp 
    210                 215                 220                 


Val Gly Tyr Pro Glu Phe Leu Asn Ile Arg Pro Tyr Met Ser Gln Asn 
225                 230                 235                 240 


Asn Gly Asp Pro Val Met Tyr Gly Leu Tyr Ala Val Leu Val His Ser 
                245                 250                 255     


Gly Tyr Ser Cys His Ala Gly His Tyr Tyr Cys Tyr Val Lys Ala Ser 
            260                 265                 270         


Asn Gly Gln Trp Tyr Gln Met Asn Asp Ser Leu Val His Ser Ser Asn 
        275                 280                 285             


Val Lys Val Val Leu Asn Gln Gln Ala Tyr Val Leu Phe Tyr Leu Arg 
    290                 295                 300                 


Ile Pro 
305     


<210> 157
<211> 411
<212> PRT
<213> Homo sapiens

<400> 157
Thr Pro Gly Val Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met 
1               5                   10                  15      


Asn Ser Val Leu Gln Val Leu Ser His Leu Leu Ile Phe Arg Gln Cys 
            20                  25                  30          


Phe Leu Lys Leu Asp Leu Asn Gln Trp Leu Ala Met Thr Ala Ser Glu 
        35                  40                  45              


Lys Thr Arg Ser Cys Lys His Pro Pro Val Thr Asp Thr Val Val Tyr 
    50                  55                  60                  


Gln Met Asn Glu Cys Gln Glu Lys Asp Thr Gly Phe Val Cys Ser Arg 
65                  70                  75                  80  


Gln Ser Ser Leu Ser Ser Gly Leu Ser Gly Gly Ala Ser Lys Gly Arg 
                85                  90                  95      


Lys Met Glu Leu Ile Gln Pro Lys Glu Pro Thr Ser Gln Tyr Ile Ser 
            100                 105                 110         


Leu Cys His Glu Leu His Thr Leu Phe Gln Val Met Trp Ser Gly Lys 
        115                 120                 125             


Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser Val Trp Arg Leu 
    130                 135                 140                 


Ile Pro Ala Phe Arg Gly Tyr Ala Gln Gln Asp Ala Gln Glu Phe Leu 
145                 150                 155                 160 


Cys Glu Leu Leu Asp Lys Ile Gln Arg Glu Leu Glu Thr Thr Gly Thr 
                165                 170                 175     


Ser Leu Pro Ala Leu Ile Pro Thr Ser Gln Arg Lys Leu Ile Lys Gln 
            180                 185                 190         


Val Leu Asn Val Val Asn Asn Ile Phe His Gly Gln Leu Leu Ser Gln 
        195                 200                 205             


Val Thr Cys Leu Ala Cys Asp Asn Lys Ser Asn Thr Ile Glu Pro Phe 
    210                 215                 220                 


Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr Gln Cys Ser Gly Lys 
225                 230                 235                 240 


Asp Ile Ala Ser Gln Pro Cys Leu Val Thr Glu Met Leu Ala Lys Phe 
                245                 250                 255     


Thr Glu Thr Glu Ala Leu Glu Gly Lys Ile Tyr Val Cys Asp Gln Cys 
            260                 265                 270         


Asn Ser Lys Arg Arg Arg Phe Ser Ser Lys Pro Val Val Leu Thr Glu 
        275                 280                 285             


Ala Gln Lys Gln Leu Met Ile Cys His Leu Pro Gln Val Leu Arg Leu 
    290                 295                 300                 


His Leu Lys Arg Phe Arg Trp Ser Gly Arg Asn Asn Arg Glu Lys Ile 
305                 310                 315                 320 


Gly Val His Val Gly Phe Glu Glu Ile Leu Asn Met Glu Pro Tyr Cys 
                325                 330                 335     


Cys Arg Glu Thr Leu Lys Ser Leu Arg Pro Glu Cys Phe Ile Tyr Asp 
            340                 345                 350         


Leu Ser Ala Val Val Met His His Gly Lys Gly Phe Gly Ser Gly His 
        355                 360                 365             


Tyr Thr Ala Tyr Cys Tyr Asn Ser Glu Gly Gly Phe Trp Val His Cys 
    370                 375                 380                 


Asn Asp Ser Lys Leu Ser Met Cys Thr Met Asp Glu Val Cys Lys Ala 
385                 390                 395                 400 


Gln Ala Tyr Ile Leu Phe Tyr Thr Gln Arg Val 
                405                 410     


<210> 158
<211> 337
<212> PRT
<213> Homo sapiens

<400> 158
Pro Ala Leu Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Ile Leu Gln Cys Leu Cys Asn Ala Pro His Leu Ala Asp Tyr Phe 
            20                  25                  30          


Asn Arg Asn Cys Tyr Gln Asp Asp Ile Asn Arg Ser Asn Leu Leu Gly 
        35                  40                  45              


His Lys Gly Glu Val Ala Glu Glu Phe Gly Ile Ile Met Lys Ala Leu 
    50                  55                  60                  


Trp Thr Gly Gln Tyr Arg Tyr Ile Ser Pro Lys Asp Phe Lys Ile Thr 
65                  70                  75                  80  


Ile Gly Lys Ile Asn Asp Gln Phe Ala Gly Tyr Ser Gln Gln Asp Ser 
                85                  90                  95      


Gln Glu Leu Leu Leu Phe Leu Met Asp Gly Leu His Glu Asp Leu Asn 
            100                 105                 110         


Lys Ala Asp Asn Arg Lys Arg Tyr Lys Glu Glu Asn Asn Asp His Leu 
        115                 120                 125             


Asp Asp Phe Lys Ala Ala Glu His Ala Trp Gln Lys His Lys Gln Leu 
    130                 135                 140                 


Asn Glu Ser Ile Ile Val Ala Leu Phe Gln Gly Gln Phe Lys Ser Thr 
145                 150                 155                 160 


Val Gln Cys Leu Thr Cys His Lys Lys Ser Arg Thr Phe Glu Ala Phe 
                165                 170                 175     


Met Tyr Leu Ser Leu Pro Leu Ala Ser Thr Ser Lys Cys Thr Leu Gln 
            180                 185                 190         


Asp Cys Leu Arg Leu Phe Ser Lys Glu Glu Lys Leu Thr Asp Asn Asn 
        195                 200                 205             


Arg Phe Tyr Cys Ser His Cys Arg Ala Arg Arg Asp Ser Leu Lys Lys 
    210                 215                 220                 


Ile Glu Ile Trp Lys Leu Pro Pro Val Leu Leu Val His Leu Lys Arg 
225                 230                 235                 240 


Phe Ser Tyr Asp Gly Arg Trp Lys Gln Lys Leu Gln Thr Ser Val Asp 
                245                 250                 255     


Phe Pro Leu Glu Asn Leu Asp Leu Ser Gln Tyr Val Ile Gly Pro Lys 
            260                 265                 270         


Asn Asn Leu Lys Lys Tyr Asn Leu Phe Ser Val Ser Asn His Tyr Gly 
        275                 280                 285             


Gly Leu Asp Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn Ala Ala Arg 
    290                 295                 300                 


Gln Arg Trp Phe Lys Phe Asp Asp His Glu Val Ser Asp Ile Ser Val 
305                 310                 315                 320 


Ser Ser Val Lys Ser Ser Ala Ala Tyr Ile Leu Phe Tyr Thr Ser Leu 
                325                 330                 335     


Gly 
    


<210> 159
<211> 614
<212> PRT
<213> Homo sapiens

<400> 159
Gln Gln Leu Gln Gly Phe Ser Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Ile Leu Gln Ser Leu Phe Ser Leu Gln Ser Phe Ala Asn Asp Leu 
            20                  25                  30          


Leu Lys Gln Gly Ile Pro Trp Lys Lys Ile Pro Leu Asn Ala Leu Ile 
        35                  40                  45              


Arg Arg Phe Ala His Leu Leu Val Lys Lys Asp Ile Cys Asn Ser Glu 
    50                  55                  60                  


Thr Lys Lys Asp Leu Leu Lys Lys Val Lys Asn Ala Ile Ser Ala Thr 
65                  70                  75                  80  


Ala Glu Arg Phe Ser Gly Tyr Met Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Ser Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn Lys 
            100                 105                 110         


Thr Trp Lys Thr Glu Pro Val Ser Gly Glu Glu Asn Ser Pro Asp Ile 
        115                 120                 125             


Ser Ala Thr Arg Ala Tyr Thr Cys Pro Val Ile Thr Asn Leu Glu Phe 
    130                 135                 140                 


Glu Val Gln His Ser Ile Ile Cys Lys Ala Cys Gly Glu Ile Ile Pro 
145                 150                 155                 160 


Lys Arg Glu Gln Phe Asn Asp Leu Ser Ile Asp Leu Pro Arg Arg Lys 
                165                 170                 175     


Lys Pro Leu Pro Pro Arg Ser Ile Gln Asp Ser Leu Asp Leu Phe Phe 
            180                 185                 190         


Arg Ala Glu Glu Leu Glu Tyr Ser Cys Glu Lys Cys Gly Gly Lys Cys 
        195                 200                 205             


Ala Leu Val Arg His Lys Phe Asn Arg Leu Pro Arg Val Leu Ile Leu 
    210                 215                 220                 


His Leu Lys Arg Tyr Ser Phe Asn Val Ala Leu Ser Leu Asn Asn Lys 
225                 230                 235                 240 


Ile Gly Gln Gln Val Ile Ile Pro Arg Tyr Leu Thr Leu Ser Ser His 
                245                 250                 255     


Cys Thr Glu Asn Thr Lys Pro Pro Phe Thr Leu Gly Trp Ser Ala His 
            260                 265                 270         


Met Ala Ile Ser Arg Pro Leu Lys Ala Ser Gln Met Val Asn Ser Cys 
        275                 280                 285             


Ile Thr Ser Pro Ser Thr Pro Ser Lys Lys Phe Thr Phe Lys Ser Lys 
    290                 295                 300                 


Ser Ser Leu Ala Leu Cys Leu Asp Ser Asp Ser Glu Asp Glu Leu Lys 
305                 310                 315                 320 


Arg Ser Val Ala Leu Ser Gln Arg Leu Cys Glu Met Leu Gly Asn Glu 
                325                 330                 335     


Gln Gln Gln Glu Asp Leu Glu Lys Asp Ser Lys Leu Cys Pro Ile Glu 
            340                 345                 350         


Pro Asp Lys Ser Glu Leu Glu Asn Ser Gly Phe Asp Arg Met Ser Glu 
        355                 360                 365             


Glu Glu Leu Leu Ala Ala Val Leu Glu Ile Ser Lys Arg Asp Ala Ser 
    370                 375                 380                 


Pro Ser Leu Ser His Glu Asp Asp Asp Lys Pro Thr Ser Ser Pro Asp 
385                 390                 395                 400 


Thr Gly Phe Ala Glu Asp Asp Ile Gln Glu Met Pro Glu Asn Pro Asp 
                405                 410                 415     


Thr Met Glu Thr Glu Lys Pro Lys Thr Ile Thr Glu Leu Asp Pro Ala 
            420                 425                 430         


Ser Phe Thr Glu Ile Thr Lys Asp Cys Asp Glu Asn Lys Glu Asn Lys 
        435                 440                 445             


Thr Pro Glu Gly Ser Gln Gly Glu Val Asp Trp Leu Gln Gln Tyr Asp 
    450                 455                 460                 


Met Glu Arg Glu Arg Glu Glu Gln Glu Leu Gln Gln Ala Leu Ala Gln 
465                 470                 475                 480 


Ser Leu Gln Glu Gln Glu Ala Trp Glu Gln Lys Glu Asp Asp Asp Leu 
                485                 490                 495     


Lys Arg Ala Thr Glu Leu Ser Leu Gln Glu Phe Asn Asn Ser Phe Val 
            500                 505                 510         


Asp Ala Leu Gly Ser Asp Glu Asp Ser Gly Asn Glu Asp Val Phe Asp 
        515                 520                 525             


Met Glu Tyr Thr Glu Ala Glu Ala Glu Glu Leu Lys Arg Asn Ala Glu 
    530                 535                 540                 


Thr Gly Asn Leu Pro His Ser Tyr Arg Leu Ile Ser Val Val Ser His 
545                 550                 555                 560 


Ile Gly Ser Thr Ser Ser Ser Gly His Tyr Ile Ser Asp Val Tyr Asp 
                565                 570                 575     


Ile Lys Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Glu Val Ser Lys 
            580                 585                 590         


Ile Gln Glu Ala Ala Val Gln Ser Asp Arg Asp Arg Ser Gly Tyr Ile 
        595                 600                 605             


Phe Phe Tyr Met His Lys 
    610                 


<210> 160
<211> 300
<212> PRT
<213> Homo sapiens

<400> 160
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His Pro Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 161
<211> 300
<212> PRT
<213> Homo sapiens

<400> 161
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ser Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 162
<211> 402
<212> PRT
<213> Homo sapiens

<400> 162
Ala Pro Ser Lys Gly Leu Ser Asn Glu Pro Gly Gln Asn Ser Cys Phe 
1               5                   10                  15      


Leu Asn Ser Ala Leu Gln Val Leu Trp His Leu Asp Ile Phe Arg Arg 
            20                  25                  30          


Ser Phe Arg Gln Leu Thr Thr His Lys Cys Met Gly Asp Ser Cys Ile 
        35                  40                  45              


Phe Cys Ala Leu Lys Gly Ile Phe Asn Gln Phe Gln Cys Ser Ser Glu 
    50                  55                  60                  


Lys Val Leu Pro Ser Asp Thr Leu Arg Ser Ala Leu Ala Lys Thr Phe 
65                  70                  75                  80  


Gln Asp Glu Gln Arg Phe Gln Leu Gly Ile Met Asp Asp Ala Ala Glu 
                85                  90                  95      


Cys Phe Glu Asn Leu Leu Met Arg Ile His Phe His Ile Ala Asp Glu 
            100                 105                 110         


Thr Lys Glu Asp Ile Cys Thr Ala Gln His Cys Ile Ser His Gln Lys 
        115                 120                 125             


Phe Ala Met Thr Leu Phe Glu Gln Cys Val Cys Thr Ser Cys Gly Ala 
    130                 135                 140                 


Thr Ser Asp Pro Leu Pro Phe Ile Gln Met Val His Tyr Ile Ser Thr 
145                 150                 155                 160 


Thr Ser Leu Cys Asn Gln Ala Ile Cys Met Leu Glu Arg Arg Glu Lys 
                165                 170                 175     


Pro Ser Pro Ser Met Phe Gly Glu Leu Leu Gln Asn Ala Ser Thr Met 
            180                 185                 190         


Gly Asp Leu Arg Asn Cys Pro Ser Asn Cys Gly Glu Arg Ile Arg Ile 
        195                 200                 205             


Arg Arg Val Leu Met Asn Ala Pro Gln Ile Ile Thr Ile Gly Leu Val 
    210                 215                 220                 


Trp Asp Ser Asp His Ser Asp Leu Ala Glu Asp Val Ile His Ser Leu 
225                 230                 235                 240 


Gly Thr Cys Leu Lys Leu Gly Asp Leu Phe Phe Arg Val Thr Asp Asp 
                245                 250                 255     


Arg Ala Lys Gln Ser Glu Leu Tyr Leu Val Gly Met Ile Cys Tyr Tyr 
            260                 265                 270         


Gly Lys His Tyr Ser Thr Phe Phe Phe Gln Thr Lys Ile Arg Lys Trp 
        275                 280                 285             


Met Tyr Phe Asp Asp Ala His Val Lys Glu Ile Gly Pro Lys Trp Lys 
    290                 295                 300                 


Asp Val Val Thr Lys Cys Ile Lys Gly His Tyr Gln Pro Leu Leu Leu 
305                 310                 315                 320 


Leu Tyr Ala Asp Pro Gln Gly Thr Pro Val Ser Thr Gln Asp Leu Pro 
                325                 330                 335     


Pro Gln Ala Glu Phe Gln Ser Tyr Ser Arg Thr Cys Tyr Asp Ser Glu 
            340                 345                 350         


Asp Ser Gly Arg Glu Pro Ser Ile Ser Ser Asp Thr Arg Thr Asp Ser 
        355                 360                 365             


Ser Thr Glu Ser Tyr Pro Tyr Lys His Ser His His Glu Ser Val Val 
    370                 375                 380                 


Ser His Phe Ser Ser Asp Ser Gln Gly Thr Val Ile Tyr Asn Val Glu 
385                 390                 395                 400 


Asn Asp 
        


<210> 163
<211> 336
<212> PRT
<213> Homo sapiens

<400> 163
Leu Pro Gly Ile Val Gly Leu Asn Asn Ile Lys Ala Asn Asp Tyr Ala 
1               5                   10                  15      


Asn Ala Val Leu Gln Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr 
            20                  25                  30          


Phe Leu Glu Glu Asp Asn Tyr Lys Asn Ile Lys Arg Pro Pro Gly Asp 
        35                  40                  45              


Ile Met Phe Leu Leu Val Gln Arg Phe Gly Glu Leu Met Arg Lys Leu 
    50                  55                  60                  


Trp Asn Pro Arg Asn Phe Lys Ala His Val Ser Pro His Glu Met Leu 
65                  70                  75                  80  


Gln Ala Val Val Leu Cys Ser Lys Lys Thr Phe Gln Ile Thr Lys Gln 
                85                  90                  95      


Gly Asp Gly Val Asp Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser 
            100                 105                 110         


Ala Leu Gly Gly Thr Lys Lys Lys Lys Lys Thr Ile Val Thr Asp Val 
        115                 120                 125             


Phe Gln Gly Ser Met Arg Ile Phe Thr Lys Lys Leu Pro His Pro Asp 
    130                 135                 140                 


Leu Pro Ala Glu Glu Lys Glu Gln Leu Leu His Asn Asp Glu Tyr Gln 
145                 150                 155                 160 


Glu Thr Met Val Glu Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro 
                165                 170                 175     


Thr Ala Pro Leu Tyr Lys Asp Glu Lys Glu Gln Leu Ile Ile Pro Gln 
            180                 185                 190         


Val Pro Leu Phe Asn Ile Leu Ala Lys Phe Asn Gly Ile Thr Glu Lys 
        195                 200                 205             


Glu Tyr Lys Thr Tyr Lys Glu Asn Phe Leu Lys Arg Phe Gln Leu Thr 
    210                 215                 220                 


Lys Leu Pro Pro Tyr Leu Ile Phe Cys Ile Lys Arg Phe Thr Lys Asn 
225                 230                 235                 240 


Asn Phe Phe Val Glu Lys Asn Pro Thr Ile Val Asn Phe Pro Ile Thr 
                245                 250                 255     


Asn Val Asp Leu Arg Glu Tyr Leu Ser Glu Glu Val Gln Ala Val His 
            260                 265                 270         


Lys Asn Thr Thr Tyr Asp Leu Ile Ala Asn Ile Val His Asp Gly Lys 
        275                 280                 285             


Pro Ser Glu Gly Ser Tyr Arg Ile His Val Leu His His Gly Thr Gly 
    290                 295                 300                 


Lys Trp Tyr Glu Leu Gln Asp Leu Gln Val Thr Asp Ile Leu Pro Gln 
305                 310                 315                 320 


Met Ile Thr Leu Ser Glu Ala Tyr Ile Gln Ile Trp Lys Arg Arg Asp 
                325                 330                 335     


<210> 164
<211> 492
<212> PRT
<213> Homo sapiens

<400> 164
Ser Asp Thr Gly Lys Ile Gly Leu Ile Asn Leu Gly Asn Thr Cys Tyr 
1               5                   10                  15      


Val Asn Ser Ile Leu Gln Ala Leu Phe Met Ala Ser Asp Phe Arg His 
            20                  25                  30          


Cys Val Leu Arg Leu Thr Glu Asn Asn Ser Gln Pro Leu Met Thr Lys 
        35                  40                  45              


Leu Gln Trp Leu Phe Gly Phe Leu Glu His Ser Gln Arg Pro Ala Ile 
    50                  55                  60                  


Ser Pro Glu Asn Phe Leu Ser Ala Ser Trp Thr Pro Trp Phe Ser Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Asp Cys Ser Glu Tyr Leu Lys Tyr Leu Leu Asp Arg 
                85                  90                  95      


Leu His Glu Glu Glu Lys Thr Gly Thr Arg Ile Cys Gln Lys Leu Lys 
            100                 105                 110         


Gln Ser Ser Ser Pro Ser Pro Pro Glu Glu Pro Pro Ala Pro Ser Ser 
        115                 120                 125             


Thr Ser Val Glu Lys Met Phe Gly Gly Lys Ile Val Thr Arg Ile Cys 
    130                 135                 140                 


Cys Leu Cys Cys Leu Asn Val Ser Ser Arg Glu Glu Ala Phe Thr Asp 
145                 150                 155                 160 


Leu Ser Leu Ala Phe Pro Pro Pro Glu Arg Cys Arg Arg Arg Arg Leu 
                165                 170                 175     


Gly Ser Val Met Arg Pro Thr Glu Asp Ile Thr Ala Arg Glu Leu Pro 
            180                 185                 190         


Pro Pro Thr Ser Ala Gln Gly Pro Gly Arg Val Gly Pro Arg Arg Gln 
        195                 200                 205             


Arg Lys His Cys Ile Thr Glu Asp Thr Pro Pro Thr Ser Leu Tyr Ile 
    210                 215                 220                 


Glu Gly Leu Asp Ser Lys Glu Ala Gly Gly Gln Ser Ser Gln Glu Glu 
225                 230                 235                 240 


Arg Ile Glu Arg Glu Glu Glu Gly Lys Glu Glu Arg Thr Glu Lys Glu 
                245                 250                 255     


Glu Val Gly Glu Glu Glu Glu Ser Thr Arg Gly Glu Gly Glu Arg Glu 
            260                 265                 270         


Lys Glu Glu Glu Val Glu Glu Glu Glu Glu Lys Val Glu Lys Glu Thr 
        275                 280                 285             


Glu Lys Glu Ala Glu Gln Glu Lys Glu Glu Asp Ser Leu Gly Ala Gly 
    290                 295                 300                 


Thr His Pro Asp Ala Ala Ile Pro Ser Gly Glu Arg Thr Cys Gly Ser 
305                 310                 315                 320 


Glu Gly Ser Arg Ser Val Leu Asp Leu Val Asn Tyr Phe Leu Ser Pro 
                325                 330                 335     


Glu Lys Leu Thr Ala Glu Asn Arg Tyr Tyr Cys Glu Ser Cys Ala Ser 
            340                 345                 350         


Leu Gln Asp Ala Glu Lys Val Val Glu Leu Ser Gln Gly Pro Cys Tyr 
        355                 360                 365             


Leu Ile Leu Thr Leu Leu Arg Phe Ser Phe Asp Leu Arg Thr Met Arg 
    370                 375                 380                 


Arg Arg Lys Ile Leu Asp Asp Val Ser Ile Pro Leu Leu Leu Arg Leu 
385                 390                 395                 400 


Pro Leu Ala Gly Gly Arg Gly Gln Ala Tyr Asp Leu Cys Ser Val Val 
                405                 410                 415     


Val His Ser Gly Val Ser Ser Glu Ser Gly His Tyr Tyr Cys Tyr Ala 
            420                 425                 430         


Arg Glu Gly Ala Ala Arg Pro Ala Ala Ser Leu Gly Thr Ala Asp Arg 
        435                 440                 445             


Pro Glu Pro Glu Asn Gln Trp Tyr Leu Phe Asn Asp Thr Arg Val Ser 
    450                 455                 460                 


Phe Ser Ser Phe Glu Ser Val Ser Asn Val Thr Ser Phe Phe Pro Lys 
465                 470                 475                 480 


Asp Thr Ala Tyr Val Leu Phe Tyr Arg Gln Arg Pro 
                485                 490         


<210> 165
<211> 651
<212> PRT
<213> Homo sapiens

<400> 165
Glu Gln Pro Gly Leu Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ala Ile Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu 
            20                  25                  30          


Tyr Phe Leu Asn Asp Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro 
        35                  40                  45              


Leu Gly Met Arg Gly Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys 
    50                  55                  60                  


Gln Met Trp Ser Gly Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys 
65                  70                  75                  80  


Thr Gln Val Gly Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln 
                85                  90                  95      


Asp Cys Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp 
            100                 105                 110         


Leu Asn Arg Ile Arg Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp 
        115                 120                 125             


Gly Arg Pro Asp Lys Val Val Ala Glu Glu Ala Trp Glu Asn His Leu 
    130                 135                 140                 


Lys Arg Asn Asp Ser Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys 
145                 150                 155                 160 


Ser Thr Leu Val Cys Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp 
                165                 170                 175     


Pro Phe Cys Tyr Leu Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr 
            180                 185                 190         


Leu Glu Val Tyr Leu Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln 
        195                 200                 205             


Tyr Lys Val Val Val Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr 
    210                 215                 220                 


Ala Leu Ser Ala Leu Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr 
225                 230                 235                 240 


Asp Ile Tyr Asn His Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn 
                245                 250                 255     


Leu Ser Ser Ile Met Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn 
            260                 265                 270         


Ile Asn Arg Thr Glu Asp Thr Glu His Val Ile Ile Pro Val Cys Leu 
        275                 280                 285             


Arg Glu Lys Phe Arg His Ser Ser Tyr Thr His His Thr Gly Ser Ser 
    290                 295                 300                 


Leu Phe Gly Gln Pro Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu 
305                 310                 315                 320 


Asp Lys Leu Tyr Asn Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys 
                325                 330                 335     


Ile Ser Thr Glu Thr Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys 
            340                 345                 350         


Asp Gln Asn Ile Asn Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly 
        355                 360                 365             


Ser Pro Ser Glu Met Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln 
    370                 375                 380                 


Asp Gln Glu Leu Pro Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser 
385                 390                 395                 400 


Val Gly Gly Asp Asn Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr 
                405                 410                 415     


Cys Lys Gly Gln Leu Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln 
            420                 425                 430         


Phe Asn Asn Leu Gly Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr 
        435                 440                 445             


Arg His Ile Arg Phe Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser 
    450                 455                 460                 


Phe Leu Ala Leu Asp Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp 
465                 470                 475                 480 


Glu Asn Ala Ala Glu Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys 
                485                 490                 495     


Pro Pro Lys Lys Pro Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe 
            500                 505                 510         


Thr Thr Lys Glu Lys Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn 
        515                 520                 525             


Cys Lys Glu His Gln Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu 
    530                 535                 540                 


Pro Pro Val Leu Val Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr 
545                 550                 555                 560 


Met Arg Asp Lys Leu Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu 
                565                 570                 575     


Asp Met Ser Glu Phe Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr 
            580                 585                 590         


Asn Leu Ile Ala Val Ser Asn His Tyr Gly Gly Met Gly Gly Gly His 
        595                 600                 605             


Tyr Thr Ala Phe Ala Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe 
    610                 615                 620                 


Asp Asp Ser Ser Val Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys 
625                 630                 635                 640 


Ala Ala Tyr Val Leu Phe Tyr Gln Arg Gln Asp 
                645                 650     


<210> 166
<211> 604
<212> PRT
<213> Homo sapiens

<400> 166
Gln Leu Gln Gln Gly Phe Pro Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Val Leu Gln Ser Leu Phe Ala Ile Pro Ser Phe Ala Asp Asp Leu 
            20                  25                  30          


Leu Thr Gln Gly Val Pro Trp Glu Tyr Ile Pro Phe Glu Ala Leu Ile 
        35                  40                  45              


Met Thr Leu Thr Gln Leu Leu Ala Leu Lys Asp Phe Cys Ser Thr Lys 
    50                  55                  60                  


Ile Lys Arg Glu Leu Leu Gly Asn Val Lys Lys Val Ile Ser Ala Val 
65                  70                  75                  80  


Ala Glu Ile Phe Ser Gly Asn Met Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Gly Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn Ala 
            100                 105                 110         


Thr Leu Asn Thr Gly Lys Glu Cys Gly Asp Glu Asn Ser Ser Pro Gln 
        115                 120                 125             


Met His Val Gly Ser Ala Ala Thr Lys Val Phe Val Cys Pro Val Val 
    130                 135                 140                 


Ala Asn Phe Glu Phe Glu Leu Gln Leu Ser Leu Ile Cys Lys Ala Cys 
145                 150                 155                 160 


Gly His Ala Val Leu Lys Val Glu Pro Asn Asn Tyr Leu Ser Ile Asn 
                165                 170                 175     


Leu His Gln Glu Thr Lys Pro Leu Pro Leu Ser Ile Gln Asn Ser Leu 
            180                 185                 190         


Asp Leu Phe Phe Lys Glu Glu Glu Leu Glu Tyr Asn Cys Gln Met Cys 
        195                 200                 205             


Lys Gln Lys Ser Cys Val Ala Arg His Thr Phe Ser Arg Leu Ser Arg 
    210                 215                 220                 


Val Leu Ile Ile His Leu Lys Arg Tyr Ser Phe Asn Asn Ala Trp Leu 
225                 230                 235                 240 


Leu Val Lys Asn Asn Glu Gln Val Tyr Ile Pro Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Ser Tyr Cys Asn Glu Ser Thr Lys Pro Pro Leu Pro Leu Ser Ser 
            260                 265                 270         


Ser Ala Pro Val Gly Lys Cys Glu Val Leu Glu Val Ser Gln Glu Met 
        275                 280                 285             


Ile Ser Glu Ile Asn Ser Pro Leu Thr Pro Ser Met Lys Leu Thr Ser 
    290                 295                 300                 


Glu Ser Ser Asp Ser Leu Val Leu Pro Val Glu Pro Asp Lys Asn Ala 
305                 310                 315                 320 


Asp Leu Gln Arg Phe Gln Arg Asp Cys Gly Asp Ala Ser Gln Glu Gln 
                325                 330                 335     


His Gln Arg Asp Leu Glu Asn Gly Ser Ala Leu Glu Ser Glu Leu Val 
            340                 345                 350         


His Phe Arg Asp Arg Ala Ile Gly Glu Lys Glu Leu Pro Val Ala Asp 
        355                 360                 365             


Ser Leu Met Asp Gln Gly Asp Ile Ser Leu Pro Val Met Tyr Glu Asp 
    370                 375                 380                 


Gly Gly Lys Leu Ile Ser Ser Pro Asp Thr Arg Leu Val Glu Val His 
385                 390                 395                 400 


Leu Gln Glu Val Pro Gln His Pro Glu Leu Gln Lys Tyr Glu Lys Thr 
                405                 410                 415     


Asn Thr Phe Val Glu Phe Asn Phe Asp Ser Val Thr Glu Ser Thr Asn 
            420                 425                 430         


Gly Phe Tyr Asp Cys Lys Glu Asn Arg Ile Pro Glu Gly Ser Gln Gly 
        435                 440                 445             


Met Ala Glu Gln Leu Gln Gln Cys Ile Glu Glu Ser Ile Ile Asp Glu 
    450                 455                 460                 


Phe Leu Gln Gln Ala Pro Pro Pro Gly Val Arg Lys Leu Asp Ala Gln 
465                 470                 475                 480 


Glu His Thr Glu Glu Thr Leu Asn Gln Ser Thr Glu Leu Arg Leu Gln 
                485                 490                 495     


Lys Ala Asp Leu Asn His Leu Gly Ala Leu Gly Ser Asp Asn Pro Gly 
            500                 505                 510         


Asn Lys Asn Ile Leu Asp Ala Glu Asn Thr Arg Gly Glu Ala Lys Glu 
        515                 520                 525             


Leu Thr Arg Asn Val Lys Met Gly Asp Pro Leu Gln Ala Tyr Arg Leu 
    530                 535                 540                 


Ile Ser Val Val Ser His Ile Gly Ser Ser Pro Asn Ser Gly His Tyr 
545                 550                 555                 560 


Ile Ser Asp Val Tyr Asp Phe Gln Lys Gln Ala Trp Phe Thr Tyr Asn 
                565                 570                 575     


Asp Leu Cys Val Ser Glu Ile Ser Glu Thr Lys Met Gln Glu Ala Arg 
            580                 585                 590         


Leu His Ser Gly Tyr Ile Phe Phe Tyr Met His Asn 
        595                 600                 


<210> 167
<211> 841
<212> PRT
<213> Homo sapiens

<400> 167
Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 
1               5                   10                  15      


Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe 
            20                  25                  30          


Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly 
        35                  40                  45              


Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu 
    50                  55                  60                  


Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr 
65                  70                  75                  80  


Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser 
                85                  90                  95      


Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 
            100                 105                 110         


Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg 
        115                 120                 125             


Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg 
    130                 135                 140                 


Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln 
145                 150                 155                 160 


Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Asn 
                165                 170                 175     


Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu Ile 
            180                 185                 190         


Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu Arg 
        195                 200                 205             


Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg Asp 
    210                 215                 220                 


Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His Asp 
225                 230                 235                 240 


Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu Ser 
                245                 250                 255     


Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser Pro 
            260                 265                 270         


Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro Ser 
        275                 280                 285             


Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys Pro 
    290                 295                 300                 


Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly Thr 
305                 310                 315                 320 


Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser Leu 
                325                 330                 335     


Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys Met 
            340                 345                 350         


Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro Ser 
        355                 360                 365             


Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg Lys 
    370                 375                 380                 


Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala Arg 
385                 390                 395                 400 


Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp Asn 
                405                 410                 415     


Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys Asp 
            420                 425                 430         


Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly Cys 
        435                 440                 445             


Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr Ile 
    450                 455                 460                 


Ala Val Asp Trp His Pro Thr Ala Leu His Leu Arg Tyr Gln Thr Ser 
465                 470                 475                 480 


Gln Glu Arg Val Val Asp Lys His Glu Ser Val Glu Gln Ser Arg Arg 
                485                 490                 495     


Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg Ala Phe Thr 
            500                 505                 510         


Ser Glu Glu Glu Leu Gly Glu Ser Glu Met Tyr Tyr Cys Ser Lys Cys 
        515                 520                 525             


Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp Arg Leu Pro 
    530                 535                 540                 


Pro Phe Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val Asn Asp Gln 
545                 550                 555                 560 


Trp Ile Lys Ser Gln Lys Ile Val Arg Phe Leu Arg Glu Ser Phe Asp 
                565                 570                 575     


Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys Gln His Lys 
            580                 585                 590         


Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Lys Pro Arg Ile Leu Ala 
        595                 600                 605             


Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly Lys Glu Asp 
    610                 615                 620                 


Met Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn Ile Ser Ser 
625                 630                 635                 640 


Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly Thr Ser Cys 
                645                 650                 655     


Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg Thr Leu Gly 
            660                 665                 670         


Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser Lys Asn Lys 
        675                 680                 685             


Pro Ser Ser Ser Lys Lys Asn Leu Asp Ala Ser Lys Glu Asn Gly Ala 
    690                 695                 700                 


Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly His Met Arg 
705                 710                 715                 720 


Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His Glu Val Ala 
                725                 730                 735     


Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly Asn Gly Cys 
            740                 745                 750         


Gly Asp Gly Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu Asp 
        755                 760                 765             


Ser Thr Asp Asp Gln Arg Glu Asp Thr His Ile Lys Pro Ile Tyr Asn 
    770                 775                 780                 


Leu Tyr Ala Ile Ser Cys His Ser Gly Ile Leu Ser Gly Gly His Tyr 
785                 790                 795                 800 


Ile Thr Tyr Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn Asp 
                805                 810                 815     


Ser Ser Cys Glu Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser Ala 
            820                 825                 830         


Tyr Ile Leu Phe Tyr Glu Gln Gln Gly 
        835                 840     


<210> 168
<211> 446
<212> PRT
<213> Homo sapiens

<400> 168
Ala Pro Thr Lys Gly Leu Leu Asn Glu Pro Gly Gln Asn Ser Cys Phe 
1               5                   10                  15      


Leu Asn Ser Ala Val Gln Val Leu Trp Gln Leu Asp Ile Phe Arg Arg 
            20                  25                  30          


Ser Leu Arg Val Leu Thr Gly His Val Cys Gln Gly Asp Ala Cys Ile 
        35                  40                  45              


Phe Cys Ala Leu Lys Thr Ile Phe Ala Gln Phe Gln His Ser Arg Glu 
    50                  55                  60                  


Lys Ala Leu Pro Ser Asp Asn Ile Arg His Ala Leu Ala Glu Ser Phe 
65                  70                  75                  80  


Lys Asp Glu Gln Arg Phe Gln Leu Gly Leu Met Asp Asp Ala Ala Glu 
                85                  90                  95      


Cys Phe Glu Asn Met Leu Glu Arg Ile His Phe His Ile Val Pro Ser 
            100                 105                 110         


Arg Asp Ala Asp Met Cys Thr Ser Lys Ser Cys Ile Thr His Gln Lys 
        115                 120                 125             


Phe Ala Met Thr Leu Tyr Glu Gln Cys Val Cys Arg Ser Cys Gly Ala 
    130                 135                 140                 


Ser Ser Asp Pro Leu Pro Phe Thr Glu Phe Val Arg Tyr Ile Ser Thr 
145                 150                 155                 160 


Thr Ala Leu Cys Asn Glu Val Glu Arg Met Leu Glu Arg His Glu Arg 
                165                 170                 175     


Phe Lys Pro Glu Met Phe Ala Glu Leu Leu Gln Ala Ala Asn Thr Thr 
            180                 185                 190         


Asp Asp Tyr Arg Lys Cys Pro Ser Asn Cys Gly Gln Lys Ile Lys Ile 
        195                 200                 205             


Arg Arg Val Leu Met Asn Cys Pro Glu Ile Val Thr Ile Gly Leu Val 
    210                 215                 220                 


Trp Asp Ser Glu His Ser Asp Leu Thr Glu Ala Val Val Arg Asn Leu 
225                 230                 235                 240 


Ala Thr His Leu Tyr Leu Pro Gly Leu Phe Tyr Arg Val Thr Asp Glu 
                245                 250                 255     


Asn Ala Lys Asn Ser Glu Leu Asn Leu Val Gly Met Ile Cys Tyr Thr 
            260                 265                 270         


Ser Gln His Tyr Cys Ala Phe Ala Phe His Thr Lys Ser Ser Lys Trp 
        275                 280                 285             


Val Phe Phe Asp Asp Ala Asn Val Lys Glu Ile Gly Thr Arg Trp Lys 
    290                 295                 300                 


Asp Val Val Ser Lys Cys Ile Arg Cys His Phe Gln Pro Leu Leu Leu 
305                 310                 315                 320 


Phe Tyr Ala Asn Pro Asp Gly Thr Ala Val Ser Thr Glu Asp Ala Leu 
                325                 330                 335     


Arg Gln Val Ile Ser Trp Ser His Tyr Lys Ser Val Ala Glu Asn Met 
            340                 345                 350         


Gly Cys Glu Lys Pro Val Ile His Lys Ser Asp Asn Leu Lys Glu Asn 
        355                 360                 365             


Gly Phe Gly Asp Gln Ala Lys Gln Arg Glu Asn Gln Lys Phe Pro Thr 
    370                 375                 380                 


Asp Asn Ile Ser Ser Ser Asn Arg Ser His Ser His Thr Gly Val Gly 
385                 390                 395                 400 


Lys Gly Pro Ala Lys Leu Ser His Ile Asp Gln Arg Glu Lys Ile Lys 
                405                 410                 415     


Asp Ile Ser Arg Glu Cys Ala Leu Lys Ala Ile Glu Gln Lys Asn Leu 
            420                 425                 430         


Leu Ser Ser Gln Arg Lys Asp Leu Glu Lys Gly Gln Arg Lys 
        435                 440                 445     


<210> 169
<211> 300
<212> PRT
<213> Homo sapiens

<400> 169
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 170
<211> 537
<212> PRT
<213> Homo sapiens

<400> 170
Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            20                  25                  30          


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        35                  40                  45              


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    50                  55                  60                  


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
65                  70                  75                  80  


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                85                  90                  95      


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            100                 105                 110         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        115                 120                 125             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    130                 135                 140                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
145                 150                 155                 160 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                165                 170                 175     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            180                 185                 190         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        195                 200                 205             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    210                 215                 220                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
225                 230                 235                 240 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                245                 250                 255     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            260                 265                 270         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        275                 280                 285             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    290                 295                 300                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
305                 310                 315                 320 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                325                 330                 335     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            340                 345                 350         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        355                 360                 365             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    370                 375                 380                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
385                 390                 395                 400 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                405                 410                 415     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            420                 425                 430         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        435                 440                 445             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    450                 455                 460                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
465                 470                 475                 480 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                485                 490                 495     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            500                 505                 510         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        515                 520                 525             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala 
    530                 535         


<210> 171
<211> 536
<212> PRT
<213> Homo sapiens

<400> 171
Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn Thr Cys Tyr Met 
1               5                   10                  15      


Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe 
            20                  25                  30          


Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys Lys Pro Ala Ile 
        35                  40                  45              


Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp His Lys Ser Arg 
    50                  55                  60                  


Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly Ile Lys Thr Val 
65                  70                  75                  80  


Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu 
                85                  90                  95      


Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys Glu Gln Val Met 
            100                 105                 110         


Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu Glu Thr Met Glu 
        115                 120                 125             


Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser Cys Glu Ser Cys 
    130                 135                 140                 


Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser Arg Cys Phe Ser 
145                 150                 155                 160 


Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp Asp Glu Asn Asn 
                165                 170                 175     


Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met Cys Asn Lys Ile 
            180                 185                 190         


Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp Arg Asp Ser Ile 
        195                 200                 205             


Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val Lys Val Gln Ile 
    210                 215                 220                 


His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His Ser Asn Asp Leu 
225                 230                 235                 240 


Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val Asn Pro Arg Leu 
                245                 250                 255     


Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro Gly Leu Ala Pro 
            260                 265                 270         


Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg Lys Lys Gln His 
        275                 280                 285             


Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp Gly Thr Ile Ile 
    290                 295                 300                 


Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser Val Thr Leu Glu 
305                 310                 315                 320 


Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys Glu Asp Leu Ala 
                325                 330                 335     


Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val Lys Ala Gly Ser 
            340                 345                 350         


Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala Phe Phe Met Glu 
        355                 360                 365             


Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser Trp Phe Trp Gly 
    370                 375                 380                 


Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe Phe Ala Arg Asp 
385                 390                 395                 400 


Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys Cys Lys Lys Leu 
                405                 410                 415     


Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe Pro Glu Ile Leu 
            420                 425                 430         


Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met Phe Ser Thr Lys 
        435                 440                 445             


Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu Asp Leu Gln Pro 
    450                 455                 460                 


Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr Tyr Asp Leu Leu 
465                 470                 475                 480 


Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly His Tyr Ile Ala 
                485                 490                 495     


Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu Phe Asp Asp Gln 
            500                 505                 510         


Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn Ala Glu Ala Tyr 
        515                 520                 525             


Val Leu Phe Tyr Arg Lys Ser Ser 
    530                 535     


<210> 172
<211> 353
<212> PRT
<213> Homo sapiens

<400> 172
Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp 
            20                  25                  30          


Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg 
        35                  40                  45              


Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp 
    50                  55                  60                  


His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val 
65                  70                  75                  80  


Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn 
            100                 105                 110         


Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro 
        115                 120                 125             


Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser 
    130                 135                 140                 


Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu 
145                 150                 155                 160 


Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu 
                165                 170                 175     


Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys 
            180                 185                 190         


Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val 
        195                 200                 205             


Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu 
    210                 215                 220                 


Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser 
225                 230                 235                 240 


Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His 
                245                 250                 255     


Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val 
            260                 265                 270         


Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His 
    290                 295                 300                 


Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln 
305                 310                 315                 320 


Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu 
                325                 330                 335     


Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met 
            340                 345                 350         


Gln 
    


<210> 173
<211> 300
<212> PRT
<213> Homo sapiens

<400> 173
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly Tyr Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 174
<211> 300
<212> PRT
<213> Homo sapiens

<400> 174
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 175
<211> 334
<212> PRT
<213> Homo sapiens

<400> 175
Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn 
1               5                   10                  15      


Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Lys Val 
            20                  25                  30          


Leu Ala Tyr Lys Ser Gln Pro Arg Lys Lys Glu Ser Leu Leu Thr Cys 
        35                  40                  45              


Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly 
    50                  55                  60                  


Val Ile Pro Pro Lys Lys Phe Ile Thr Arg Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr 
                85                  90                  95      


Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Arg Lys Gln Glu 
            100                 105                 110         


Lys Gln Asn Gly Arg Leu Pro Asn Gly Asn Ile Asp Asn Glu Asn Asn 
        115                 120                 125             


Asn Ser Thr Pro Asp Pro Thr Trp Val His Glu Ile Phe Gln Gly Thr 
    130                 135                 140                 


Leu Thr Asn Glu Thr Arg Cys Leu Thr Cys Glu Thr Ile Ser Ser Lys 
145                 150                 155                 160 


Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser 
                165                 170                 175     


Ile Thr His Cys Leu Arg Gly Phe Ser Asn Thr Glu Thr Leu Cys Ser 
            180                 185                 190         


Glu Tyr Lys Tyr Tyr Cys Glu Glu Cys Arg Ser Lys Gln Glu Ala His 
        195                 200                 205             


Lys Arg Met Lys Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu 
    210                 215                 220                 


Lys Arg Phe Lys Tyr Met Asp Gln Leu His Arg Tyr Thr Lys Leu Ser 
225                 230                 235                 240 


Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Gly 
                245                 250                 255     


Asp Ala Thr Asn Pro Asp Arg Met Tyr Asp Leu Val Ala Val Val Val 
            260                 265                 270         


His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Ala Ile Val Lys 
        275                 280                 285             


Ser His Asp Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile 
    290                 295                 300                 


Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser 
305                 310                 315                 320 


Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg 
                325                 330                 


<210> 176
<211> 300
<212> PRT
<213> Homo sapiens

<400> 176
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Leu Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 177
<211> 546
<212> PRT
<213> Homo sapiens

<400> 177
Pro Arg Gly Leu Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met 
1               5                   10                  15      


Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe 
            20                  25                  30          


Phe Leu Glu Cys Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu 
        35                  40                  45              


Cys Lys Ser Tyr Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg 
    50                  55                  60                  


Pro Ser Tyr Val Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val 
65                  70                  75                  80  


Asn Pro Met Phe Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu 
                85                  90                  95      


Arg Cys Leu Met Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val 
            100                 105                 110         


Ala Thr Val Ala Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr 
        115                 120                 125             


Asp Glu Lys Arg Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu 
    130                 135                 140                 


Ser Cys Asp Ser Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg 
145                 150                 155                 160 


Gly Gly Gly Ser Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu 
                165                 170                 175     


Ala Gly Arg Ala Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe 
            180                 185                 190         


Ser Trp Gly Gln Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala 
        195                 200                 205             


Asp Val Asp Thr Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala 
    210                 215                 220                 


Gln Pro Pro Ser Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro 
225                 230                 235                 240 


Asp Asn Asp Ala His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val 
                245                 250                 255     


His His His Glu Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala 
            260                 265                 270         


Ser Pro Val Arg Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val 
        275                 280                 285             


Leu Ser Ala Gly Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val 
    290                 295                 300                 


Ile Ser Asp Ile Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu 
305                 310                 315                 320 


Thr Cys Asp Arg Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser 
                325                 330                 335     


Leu Pro Ile Pro Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile 
            340                 345                 350         


Tyr Gln Asn Val Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala 
        355                 360                 365             


Ala Gln Gly Trp Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val 
    370                 375                 380                 


Val Ser Cys Thr Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu 
385                 390                 395                 400 


Asp Cys Leu Ala Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn 
                405                 410                 415     


Met Tyr Ser Cys Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr 
            420                 425                 430         


Cys Lys Val Leu Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg 
        435                 440                 445             


Phe Arg His Glu Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser 
    450                 455                 460                 


Phe Pro Leu Glu Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys 
465                 470                 475                 480 


Thr Ser Gln Ile Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His 
                485                 490                 495     


Gly Thr Ala Gly Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile 
            500                 505                 510         


Asn Gly Gln Trp Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His 
        515                 520                 525             


Glu Thr Val Val Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys 
    530                 535                 540                 


Ser Ser 
545     


<210> 178
<211> 334
<212> PRT
<213> Homo sapiens

<400> 178
Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn 
1               5                   10                  15      


Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Asn Val 
            20                  25                  30          


Leu Ala Tyr Lys Ala Gln Gln Lys Lys Lys Glu Asn Leu Leu Thr Cys 
        35                  40                  45              


Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly 
    50                  55                  60                  


Val Ile Pro Pro Lys Lys Phe Ile Ser Arg Leu Arg Lys Glu Asn Asp 
65                  70                  75                  80  


Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr 
                85                  90                  95      


Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Lys Lys Gln Glu 
            100                 105                 110         


Lys Gln Asn Gly Lys Leu Lys Asn Gly Asn Met Asn Glu Pro Ala Glu 
        115                 120                 125             


Asn Asn Lys Pro Glu Leu Thr Trp Val His Glu Ile Phe Gln Gly Thr 
    130                 135                 140                 


Leu Thr Asn Glu Thr Arg Cys Leu Asn Cys Glu Thr Val Ser Ser Lys 
145                 150                 155                 160 


Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser 
                165                 170                 175     


Ile Thr His Cys Leu Arg Asp Phe Ser Asn Thr Glu Thr Leu Cys Ser 
            180                 185                 190         


Glu Gln Lys Tyr Tyr Cys Glu Thr Cys Cys Ser Lys Gln Glu Ala Gln 
        195                 200                 205             


Lys Arg Met Arg Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu 
    210                 215                 220                 


Lys Arg Phe Lys Tyr Met Glu Gln Leu His Arg Tyr Thr Lys Leu Ser 
225                 230                 235                 240 


Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Ser 
                245                 250                 255     


Asp Ala Val Asn Leu Asp Arg Met Tyr Asp Leu Val Ala Val Val Val 
            260                 265                 270         


His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Thr Ile Val Lys 
        275                 280                 285             


Ser His Gly Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile 
    290                 295                 300                 


Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser 
305                 310                 315                 320 


Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg 
                325                 330                 


<210> 179
<211> 363
<212> PRT
<213> Homo sapiens

<400> 179
Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp 
1               5                   10                  15      


Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val 
            20                  25                  30          


Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr 
        35                  40                  45              


Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly 
    50                  55                  60                  


Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys 
65                  70                  75                  80  


Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu 
                85                  90                  95      


Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu 
            100                 105                 110         


Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln 
        115                 120                 125             


Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln 
    130                 135                 140                 


Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala 
145                 150                 155                 160 


Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys 
                165                 170                 175     


Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu 
            180                 185                 190         


Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met 
        195                 200                 205             


Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys 
    210                 215                 220                 


Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro 
225                 230                 235                 240 


Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu 
                245                 250                 255     


Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu 
            260                 265                 270         


Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val 
        275                 280                 285             


Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala 
    290                 295                 300                 


Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro 
305                 310                 315                 320 


Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His 
                325                 330                 335     


Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys 
            340                 345                 350         


Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro Thr 
        355                 360             


<210> 180
<211> 631
<212> PRT
<213> Homo sapiens

<400> 180
Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
1               5                   10                  15      


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
            20                  25                  30          


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
        35                  40                  45              


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
    50                  55                  60                  


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
65                  70                  75                  80  


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
                85                  90                  95      


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
            100                 105                 110         


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
        115                 120                 125             


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
    130                 135                 140                 


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
145                 150                 155                 160 


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
                165                 170                 175     


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
            180                 185                 190         


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
        195                 200                 205             


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
    210                 215                 220                 


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
225                 230                 235                 240 


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
                245                 250                 255     


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
            260                 265                 270         


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
        275                 280                 285             


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
    290                 295                 300                 


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
305                 310                 315                 320 


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
                325                 330                 335     


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
            340                 345                 350         


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
        355                 360                 365             


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
    370                 375                 380                 


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
385                 390                 395                 400 


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
                405                 410                 415     


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
            420                 425                 430         


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
        435                 440                 445             


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
    450                 455                 460                 


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
465                 470                 475                 480 


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
                485                 490                 495     


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
            500                 505                 510         


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
        515                 520                 525             


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
    530                 535                 540                 


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
545                 550                 555                 560 


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
                565                 570                 575     


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
            580                 585                 590         


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
        595                 600                 605             


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
    610                 615                 620                 


Leu Phe Tyr Glu Arg Ile Leu 
625                 630     


<210> 181
<211> 291
<212> PRT
<213> Homo sapiens

<400> 181
Tyr Arg Tyr Lys Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu 
1               5                   10                  15      


Val Ile Ser His Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys 
            20                  25                  30          


Gly Lys Pro Leu Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His 
        35                  40                  45              


Gln Leu Glu Leu Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr 
    50                  55                  60                  


Cys Thr Cys Arg Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala 
65                  70                  75                  80  


Ser Ala Pro Gly Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala 
                85                  90                  95      


Phe Ser Gly Leu Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln 
            100                 105                 110         


Ala Leu Val Thr Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser 
        115                 120                 125             


Cys His Ala Phe Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met 
    130                 135                 140                 


His Lys Gly Trp Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala 
145                 150                 155                 160 


Ser Met Asp Glu Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr 
                165                 170                 175     


Ala Lys Asp Ala Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe 
            180                 185                 190         


Cys Ser Gln Val His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr 
        195                 200                 205             


Met Arg Glu Asn Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe 
    210                 215                 220                 


Glu Lys Tyr Leu Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln 
225                 230                 235                 240 


Leu Glu Ile Arg Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu 
                245                 250                 255     


Tyr Arg Phe Pro Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr 
            260                 265                 270         


Glu Asp Lys Ile Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser 
        275                 280                 285             


Val Tyr Ser 
    290     


<210> 182
<211> 212
<212> PRT
<213> Homo sapiens

<400> 182
Gln Gly Leu Ser Ser Arg Thr Arg Val Arg Glu Leu Gln Gly Gln Ile 
1               5                   10                  15      


Ala Ala Ile Thr Gly Ile Ala Pro Gly Gly Gln Arg Ile Leu Val Gly 
            20                  25                  30          


Tyr Pro Pro Glu Cys Leu Asp Leu Ser Asn Gly Asp Thr Ile Leu Glu 
        35                  40                  45              


Asp Leu Pro Ile Gln Ser Gly Asp Met Leu Ile Ile Glu Glu Asp Gln 
    50                  55                  60                  


Thr Arg Pro Arg Ser Ser Pro Ala Phe Thr Lys Arg Gly Ala Ser Ser 
65                  70                  75                  80  


Tyr Val Arg Glu Thr Leu Pro Val Leu Thr Arg Thr Val Val Pro Ala 
                85                  90                  95      


Asp Asn Ser Cys Leu Phe Thr Ser Val Tyr Tyr Val Val Glu Gly Gly 
            100                 105                 110         


Val Leu Asn Pro Ala Cys Ala Pro Glu Met Arg Arg Leu Ile Ala Gln 
        115                 120                 125             


Ile Val Ala Ser Asp Pro Asp Phe Tyr Ser Glu Ala Ile Leu Gly Lys 
    130                 135                 140                 


Thr Asn Gln Glu Tyr Cys Asp Trp Ile Lys Arg Asp Asp Thr Trp Gly 
145                 150                 155                 160 


Gly Ala Ile Glu Ile Ser Ile Leu Ser Lys Phe Tyr Gln Cys Glu Ile 
                165                 170                 175     


Cys Val Val Asp Thr Gln Thr Val Arg Ile Asp Arg Phe Gly Glu Asp 
            180                 185                 190         


Ala Gly Tyr Thr Lys Arg Val Leu Leu Ile Tyr Asp Gly Ile His Tyr 
        195                 200                 205             


Asp Pro Leu Gln 
    210         


<210> 183
<211> 375
<212> PRT
<213> Homo sapiens

<400> 183
His Arg Glu Ala Ala Ala Val Pro Ala Ala Lys Met Pro Ala Phe Ser 
1               5                   10                  15      


Ser Cys Phe Glu Val Val Ser Gly Ala Ala Ala Pro Ala Ser Ala Ala 
            20                  25                  30          


Ala Gly Pro Pro Gly Ala Ser Cys Lys Pro Pro Leu Pro Pro His Tyr 
        35                  40                  45              


Thr Ser Thr Ala Gln Ile Thr Val Arg Ala Leu Gly Ala Asp Arg Leu 
    50                  55                  60                  


Leu Leu His Gly Pro Asp Pro Val Pro Gly Ala Ala Gly Ser Ala Ala 
65                  70                  75                  80  


Ala Pro Arg Gly Arg Cys Leu Leu Leu Ala Pro Ala Pro Ala Ala Pro 
                85                  90                  95      


Val Pro Pro Arg Arg Gly Ser Ser Ala Trp Leu Leu Glu Glu Leu Leu 
            100                 105                 110         


Arg Pro Asp Cys Pro Glu Pro Ala Gly Leu Asp Ala Thr Arg Glu Gly 
        115                 120                 125             


Pro Asp Arg Asn Phe Arg Leu Ser Glu His Arg Gln Ala Leu Ala Ala 
    130                 135                 140                 


Ala Lys His Arg Gly Pro Ala Ala Thr Pro Gly Ser Pro Asp Pro Gly 
145                 150                 155                 160 


Pro Gly Pro Trp Gly Glu Glu His Leu Ala Glu Arg Gly Pro Arg Gly 
                165                 170                 175     


Trp Glu Arg Gly Gly Asp Arg Cys Asp Ala Pro Gly Gly Asp Ala Ala 
            180                 185                 190         


Arg Arg Pro Asp Pro Glu Ala Glu Ala Pro Pro Ala Gly Ser Ile Glu 
        195                 200                 205             


Ala Ala Pro Ser Ser Ala Ala Glu Pro Val Ile Val Ser Arg Ser Asp 
    210                 215                 220                 


Pro Arg Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln 
225                 230                 235                 240 


Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro 
                245                 250                 255     


Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp 
            260                 265                 270         


Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala 
        275                 280                 285             


Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu 
    290                 295                 300                 


Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu 
305                 310                 315                 320 


Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr 
                325                 330                 335     


Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu 
            340                 345                 350         


Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser 
        355                 360                 365             


Asn Gly His Tyr Asp Ala Val 
    370                 375 


<210> 184
<211> 213
<212> PRT
<213> Homo sapiens

<400> 184
Gln Lys His Arg Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu 
1               5                   10                  15      


Asn Lys Ile Asp Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu 
            20                  25                  30          


Asn Gln Pro Pro Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys 
        35                  40                  45              


Ala Ala Leu Glu Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile 
    50                  55                  60                  


Glu Asn Leu Thr Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln 
65                  70                  75                  80  


Ile Leu Ala Ala Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly 
                85                  90                  95      


His Cys Met Tyr Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys 
            100                 105                 110         


Ala Leu Thr Val Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln 
        115                 120                 125             


Ser His Val Glu Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly 
    130                 135                 140                 


Asp Met Tyr Thr Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val 
145                 150                 155                 160 


Asn Thr Ala Ala Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His 
                165                 170                 175     


Ile Leu Gln Thr Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile 
            180                 185                 190         


Ile Val Gly Glu Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met 
        195                 200                 205             


Arg His Ala Tyr Gly 
    210             


<210> 185
<211> 204
<212> PRT
<213> Homo sapiens

<400> 185
Gln Glu Leu Glu Lys Phe Gln Asp Asp Ser Ser Ile Glu Ser Val Val 
1               5                   10                  15      


Glu Asp Leu Ala Lys Met Asn Leu Glu Asn Arg Pro Pro Arg Ser Ser 
            20                  25                  30          


Lys Ala His Arg Lys Arg Glu Arg Met Glu Ser Glu Glu Arg Glu Arg 
        35                  40                  45              


Gln Glu Ser Ile Phe Gln Ala Glu Met Ser Glu His Leu Ala Gly Phe 
    50                  55                  60                  


Lys Arg Glu Glu Glu Glu Lys Leu Ala Ala Ile Leu Gly Ala Arg Gly 
65                  70                  75                  80  


Leu Glu Met Lys Ala Ile Pro Ala Asp Gly His Cys Met Tyr Arg Ala 
                85                  90                  95      


Ile Gln Asp Gln Leu Val Phe Ser Val Ser Val Glu Met Leu Arg Cys 
            100                 105                 110         


Arg Thr Ala Ser Tyr Met Lys Lys His Val Asp Glu Phe Leu Pro Phe 
        115                 120                 125             


Phe Ser Asn Pro Glu Thr Ser Asp Ser Phe Gly Tyr Asp Asp Phe Met 
    130                 135                 140                 


Ile Tyr Cys Asp Asn Ile Val Arg Thr Thr Ala Trp Gly Gly Gln Leu 
145                 150                 155                 160 


Glu Leu Arg Ala Leu Ser His Val Leu Lys Thr Pro Ile Glu Val Ile 
                165                 170                 175     


Gln Ala Asp Ser Pro Thr Leu Ile Ile Gly Glu Glu Tyr Val Lys Lys 
            180                 185                 190         


Pro Ile Ile Leu Val Tyr Leu Arg Tyr Ala Tyr Ser 
        195                 200                 


<210> 186
<211> 311
<212> PRT
<213> Homo sapiens

<400> 186
Ser Asp Tyr Glu Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His 
1               5                   10                  15      


Val Phe Asn Glu Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln 
            20                  25                  30          


Pro Gly His Lys Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile 
        35                  40                  45              


Ala Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala 
    50                  55                  60                  


Ile Val Ser Leu Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu 
65                  70                  75                  80  


Gln Phe Pro Leu Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu 
                85                  90                  95      


Ser Val Tyr Ser Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
            100                 105                 110         


Glu Gln Ala Thr Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
        115                 120                 125             


Trp Ser Thr Val Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr 
    130                 135                 140                 


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
145                 150                 155                 160 


Gly Phe His Asp Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met 
                165                 170                 175     


Met Arg Thr Gly Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp 
            180                 185                 190         


Gln Gln Thr Gln Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr 
        195                 200                 205             


Glu Leu Leu Lys Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys 
    210                 215                 220                 


Asn Gly Gly Thr Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr 
225                 230                 235                 240 


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg 
                245                 250                 255     


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
            260                 265                 270         


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
        275                 280                 285             


Val Pro Pro Asn Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp 
    290                 295                 300                 


Gln Ala His Phe Ser Ala Leu 
305                 310     


<210> 187
<211> 154
<212> PRT
<213> Homo sapiens

<400> 187
Met Glu Ala Ala Val Gly Val Pro Asp Gly Gly Asp Gln Gly Gly Ala 
1               5                   10                  15      


Gly Pro Arg Glu Asp Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            20                  25                  30          


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        35                  40                  45              


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    50                  55                  60                  


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
65                  70                  75                  80  


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                85                  90                  95      


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            100                 105                 110         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        115                 120                 125             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    130                 135                 140                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro 
145                 150                 


<210> 188
<211> 188
<212> PRT
<213> Homo sapiens

<400> 188
Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 
1               5                   10                  15      


Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 
            20                  25                  30          


Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 
        35                  40                  45              


Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 
    50                  55                  60                  


Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 
65                  70                  75                  80  


Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 
                85                  90                  95      


Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 
            100                 105                 110         


Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 
        115                 120                 125             


Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 
    130                 135                 140                 


Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 
145                 150                 155                 160 


Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 
                165                 170                 175     


Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg 
            180                 185             


<210> 189
<211> 362
<212> PRT
<213> Homo sapiens

<400> 189
Met Thr Leu Asp Met Asp Ala Val Leu Ser Asp Phe Val Arg Ser Thr 
1               5                   10                  15      


Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu Leu Glu Gly Lys Asn Trp 
            20                  25                  30          


Asp Val Asn Ala Ala Leu Ser Asp Phe Glu Gln Leu Arg Gln Val His 
        35                  40                  45              


Ala Gly Asn Leu Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
    50                  55                  60                  


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
65                  70                  75                  80  


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
                85                  90                  95      


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
            100                 105                 110         


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
        115                 120                 125             


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
    130                 135                 140                 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
145                 150                 155                 160 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
                165                 170                 175     


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
            180                 185                 190         


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
        195                 200                 205             


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
    210                 215                 220                 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
225                 230                 235                 240 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
                245                 250                 255     


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
            260                 265                 270         


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
        275                 280                 285             


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
    290                 295                 300                 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
305                 310                 315                 320 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
                325                 330                 335     


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
            340                 345                 350         


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu 
        355                 360         


<210> 190
<211> 338
<212> PRT
<213> Homo sapiens

<400> 190
Met Thr Ile Leu Pro Lys Lys Lys Pro Pro Pro Pro Asp Ala Asp Pro 
1               5                   10                  15      


Ala Asn Glu Pro Pro Pro Pro Gly Pro Met Pro Pro Ala Pro Arg Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Val Gly Gly Gly Gly Thr Gly Val Gly Gly Gly 
        35                  40                  45              


Asp Arg Asp Arg Asp Ser Gly Val Val Gly Ala Arg Pro Arg Ala Ser 
    50                  55                  60                  


Pro Pro Pro Gln Gly Pro Leu Pro Gly Pro Pro Gly Ala Leu His Arg 
65                  70                  75                  80  


Trp Ala Leu Ala Val Pro Pro Gly Ala Val Ala Gly Pro Arg Pro Gln 
                85                  90                  95      


Gln Ala Ser Pro Pro Pro Cys Gly Gly Pro Gly Gly Pro Gly Gly Gly 
            100                 105                 110         


Pro Gly Asp Ala Leu Gly Ala Ala Ala Ala Gly Val Gly Ala Ala Gly 
        115                 120                 125             


Val Val Val Gly Val Gly Gly Ala Val Gly Val Gly Gly Cys Cys Ser 
    130                 135                 140                 


Gly Pro Gly His Ser Lys Arg Arg Arg Gln Ala Pro Gly Val Gly Ala 
145                 150                 155                 160 


Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val Gly Ala Gly Tyr Asn 
                165                 170                 175     


Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg Ile Glu Ala Met Asp 
            180                 185                 190         


Pro Ala Thr Val Glu Gln Gln Glu His Trp Phe Glu Lys Ala Leu Arg 
        195                 200                 205             


Asp Lys Lys Gly Phe Ile Ile Lys Gln Met Lys Glu Asp Gly Ala Cys 
    210                 215                 220                 


Leu Phe Arg Ala Val Ala Asp Gln Val Tyr Gly Asp Gln Asp Met His 
225                 230                 235                 240 


Glu Val Val Arg Lys His Cys Met Asp Tyr Leu Met Lys Asn Ala Asp 
                245                 250                 255     


Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr Thr Tyr Ile Asn Arg 
            260                 265                 270         


Lys Arg Lys Asn Asn Cys His Gly Asn His Ile Glu Met Gln Ala Met 
        275                 280                 285             


Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gln Tyr Ser Thr Gly 
    290                 295                 300                 


Thr Ser Ala Val Glu Pro Ile Asn Thr Phe His Gly Ile His Gln Asn 
305                 310                 315                 320 


Glu Asp Glu Pro Ile Arg Val Ser Tyr His Arg Asn Ile His Tyr Asn 
                325                 330                 335     


Ser Val 
        


<210> 191
<211> 260
<212> PRT
<213> Homo sapiens

<400> 191
Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu 
            260 


<210> 192
<211> 589
<212> PRT
<213> Homo sapiens

<400> 192
Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu 
1               5                   10                  15      


Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala Gln Arg Pro 
            20                  25                  30          


Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp 
        35                  40                  45              


Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro 
    50                  55                  60                  


Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr 
65                  70                  75                  80  


Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu 
                85                  90                  95      


Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser Gln Arg Arg 
            100                 105                 110         


Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser Gly Ser Arg 
        115                 120                 125             


Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn 
    130                 135                 140                 


Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val Cys Thr Tyr 
145                 150                 155                 160 


Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg 
                165                 170                 175     


Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu Glu Ala Ser 
            180                 185                 190         


Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser 
        195                 200                 205             


Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser 
    210                 215                 220                 


Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly Ala Val Gly 
225                 230                 235                 240 


Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
                245                 250                 255     


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
            260                 265                 270         


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
        275                 280                 285             


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
    290                 295                 300                 


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
305                 310                 315                 320 


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
                325                 330                 335     


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
            340                 345                 350         


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
        355                 360                 365             


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
    370                 375                 380                 


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
385                 390                 395                 400 


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
                405                 410                 415     


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
            420                 425                 430         


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
        435                 440                 445             


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
    450                 455                 460                 


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
465                 470                 475                 480 


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
                485                 490                 495     


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
            500                 505                 510         


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
        515                 520                 525             


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
    530                 535                 540                 


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
545                 550                 555                 560 


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
                565                 570                 575     


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu 
            580                 585                 


<210> 193
<211> 298
<212> PRT
<213> Homo sapiens

<400> 193
Pro Ala Ser Gly Ser Val Ser Ile Glu Cys Thr Glu Cys Gly Gln Arg 
1               5                   10                  15      


His Glu Gln Gln Gln Leu Leu Gly Val Glu Glu Val Thr Asp Pro Asp 
            20                  25                  30          


Val Val Leu His Asn Leu Leu Arg Asn Ala Leu Leu Gly Val Thr Gly 
        35                  40                  45              


Ala Pro Lys Lys Asn Thr Glu Leu Val Lys Val Met Gly Leu Ser Asn 
    50                  55                  60                  


Tyr His Cys Lys Leu Leu Ser Pro Ile Leu Ala Arg Tyr Gly Met Asp 
65                  70                  75                  80  


Lys Gln Thr Gly Arg Ala Lys Leu Leu Arg Asp Met Asn Gln Gly Glu 
                85                  90                  95      


Leu Phe Asp Cys Ala Leu Leu Gly Asp Arg Ala Phe Leu Ile Glu Pro 
            100                 105                 110         


Glu His Val Asn Thr Val Gly Tyr Gly Lys Asp Arg Ser Gly Ser Leu 
        115                 120                 125             


Leu Tyr Leu His Asp Thr Leu Glu Asp Ile Lys Arg Ala Asn Lys Ser 
    130                 135                 140                 


Gln Glu Cys Leu Ile Pro Val His Val Asp Gly Asp Gly His Cys Leu 
145                 150                 155                 160 


Val His Ala Val Ser Arg Ala Leu Val Gly Arg Glu Leu Phe Trp His 
                165                 170                 175     


Ala Leu Arg Glu Asn Leu Lys Gln His Phe Gln Gln His Leu Ala Arg 
            180                 185                 190         


Tyr Gln Ala Leu Phe His Asp Phe Ile Asp Ala Ala Glu Trp Glu Asp 
        195                 200                 205             


Ile Ile Asn Glu Cys Asp Pro Leu Phe Val Pro Pro Glu Gly Val Pro 
    210                 215                 220                 


Leu Gly Leu Arg Asn Ile His Ile Phe Gly Leu Ala Asn Val Leu His 
225                 230                 235                 240 


Arg Pro Ile Ile Leu Leu Asp Ser Leu Ser Gly Met Arg Ser Ser Gly 
                245                 250                 255     


Asp Tyr Ser Ala Thr Phe Leu Pro Gly Leu Ile Pro Ala Glu Lys Cys 
            260                 265                 270         


Thr Gly Lys Asp Gly His Leu Asn Lys Pro Ile Cys Ile Ala Trp Ser 
        275                 280                 285             


Ser Ser Gly Arg Asn His Tyr Ile Pro Leu 
    290                 295             


<210> 194
<211> 227
<212> PRT
<213> Homo sapiens

<400> 194
Gln Arg Trp Leu Pro Leu Glu Ala Asn Pro Glu Val Thr Asn Gln Phe 
1               5                   10                  15      


Leu Lys Gln Leu Gly Leu His Pro Asn Trp Gln Phe Val Asp Val Tyr 
            20                  25                  30          


Gly Met Asp Pro Glu Leu Leu Ser Met Val Pro Arg Pro Val Cys Ala 
        35                  40                  45              


Val Leu Leu Leu Phe Pro Ile Thr Glu Lys Tyr Glu Val Phe Arg Thr 
    50                  55                  60                  


Glu Glu Glu Glu Lys Ile Lys Ser Gln Gly Gln Asp Val Thr Ser Ser 
65                  70                  75                  80  


Val Tyr Phe Met Lys Gln Thr Ile Ser Asn Ala Cys Gly Thr Ile Gly 
                85                  90                  95      


Leu Ile His Ala Ile Ala Asn Asn Lys Asp Lys Met His Phe Glu Ser 
            100                 105                 110         


Gly Ser Thr Leu Lys Lys Phe Leu Glu Glu Ser Val Ser Met Ser Pro 
        115                 120                 125             


Glu Glu Arg Ala Arg Tyr Leu Glu Asn Tyr Asp Ala Ile Arg Val Thr 
    130                 135                 140                 


His Glu Thr Ser Ala His Glu Gly Gln Thr Glu Ala Pro Ser Ile Asp 
145                 150                 155                 160 


Glu Lys Val Asp Leu His Phe Ile Ala Leu Val His Val Asp Gly His 
                165                 170                 175     


Leu Tyr Glu Leu Asp Gly Arg Lys Pro Phe Pro Ile Asn His Gly Glu 
            180                 185                 190         


Thr Ser Asp Glu Thr Leu Leu Glu Asp Ala Ile Glu Val Cys Lys Lys 
        195                 200                 205             


Phe Met Glu Arg Asp Pro Asp Glu Leu Arg Phe Asn Ala Ile Ala Leu 
    210                 215                 220                 


Ser Ala Ala 
225         


<210> 195
<211> 223
<212> PRT
<213> Homo sapiens

<400> 195
Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly Val Phe Thr Glu Leu 
1               5                   10                  15      


Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val Glu Glu Ile Trp Ser 
            20                  25                  30          


Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro Val His Gly Leu Ile 
        35                  40                  45              


Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro Ala Gly Ser Val Val 
    50                  55                  60                  


Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala Lys Gln Val Ile Asn 
65                  70                  75                  80  


Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val Leu Leu Asn Cys Thr 
                85                  90                  95      


His Gln Asp Val His Leu Gly Glu Thr Leu Ser Glu Phe Lys Glu Phe 
            100                 105                 110         


Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu Ala Leu Ser Asn Ser 
        115                 120                 125             


Asp Val Ile Arg Gln Val His Asn Ser Phe Ala Arg Gln Gln Met Phe 
    130                 135                 140                 


Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu Asp Ala Phe His Phe 
145                 150                 155                 160 


Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr Glu Leu Asp Gly Leu 
                165                 170                 175     


Arg Glu Gly Pro Ile Asp Leu Gly Ala Cys Asn Gln Asp Asp Trp Ile 
            180                 185                 190         


Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile Gln Lys Tyr Ser Glu 
        195                 200                 205             


Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val Ser Asp Arg Lys 
    210                 215                 220             


<210> 196
<211> 165
<212> PRT
<213> Homo sapiens

<400> 196
Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln His 
1               5                   10                  15      


Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu Leu 
            20                  25                  30          


Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met Ala 
        35                  40                  45              


Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln Pro 
    50                  55                  60                  


Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile Ser 
65                  70                  75                  80  


Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser Pro 
                85                  90                  95      


Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe Ile 
            100                 105                 110         


Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys Gln 
        115                 120                 125             


Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser Asp 
    130                 135                 140                 


Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr Ser 
145                 150                 155                 160 


Ile Phe Val Val Lys 
                165 


<210> 197
<211> 163
<212> PRT
<213> Homo sapiens

<400> 197
Pro Thr Val Tyr His Glu Arg Gln Arg Leu Glu Leu Cys Ala Val His 
1               5                   10                  15      


Ala Leu Asn Asn Val Leu Gln Gln Gln Leu Phe Ser Gln Glu Ala Ala 
            20                  25                  30          


Asp Glu Ile Cys Lys Arg Leu Ala Pro Asp Ser Arg Leu Asn Pro His 
        35                  40                  45              


Arg Ser Leu Leu Gly Thr Gly Asn Tyr Asp Val Asn Val Ile Met Ala 
    50                  55                  60                  


Ala Leu Gln Gly Leu Gly Leu Ala Ala Val Trp Trp Asp Arg Arg Arg 
65                  70                  75                  80  


Pro Leu Ser Gln Leu Ala Leu Pro Gln Val Leu Gly Leu Ile Leu Asn 
                85                  90                  95      


Leu Pro Ser Pro Val Ser Leu Gly Leu Leu Ser Leu Pro Leu Arg Arg 
            100                 105                 110         


Arg His Trp Val Ala Leu Arg Gln Val Asp Gly Val Tyr Tyr Asn Leu 
        115                 120                 125             


Asp Ser Lys Leu Arg Ala Pro Glu Ala Leu Gly Asp Glu Asp Gly Val 
    130                 135                 140                 


Arg Ala Phe Leu Ala Ala Ala Leu Ala Gln Gly Leu Cys Glu Val Leu 
145                 150                 155                 160 


Leu Val Val 
            


<210> 198
<211> 170
<212> PRT
<213> Homo sapiens

<400> 198
Pro Gln Ala Ala Pro Pro Gln Ile Tyr His Glu Lys Gln Arg Arg Glu 
1               5                   10                  15      


Leu Cys Ala Leu His Ala Leu Asn Asn Val Phe Gln Asp Ser Asn Ala 
            20                  25                  30          


Phe Thr Arg Asp Thr Leu Gln Glu Ile Phe Gln Arg Leu Ser Pro Asn 
        35                  40                  45              


Thr Met Val Thr Pro His Lys Lys Ser Met Leu Gly Asn Gly Asn Tyr 
    50                  55                  60                  


Asp Val Asn Val Ile Met Ala Ala Leu Gln Thr Lys Gly Tyr Glu Ala 
65                  70                  75                  80  


Val Trp Trp Asp Lys Arg Arg Asp Val Gly Val Ile Ala Leu Thr Asn 
                85                  90                  95      


Val Met Gly Phe Ile Met Asn Leu Pro Ser Ser Leu Cys Trp Gly Pro 
            100                 105                 110         


Leu Lys Leu Pro Leu Lys Arg Gln His Trp Ile Cys Val Arg Glu Val 
        115                 120                 125             


Gly Gly Ala Tyr Tyr Asn Leu Asp Ser Lys Leu Lys Met Pro Glu Trp 
    130                 135                 140                 


Ile Gly Gly Glu Ser Glu Leu Arg Lys Phe Leu Lys His His Leu Arg 
145                 150                 155                 160 


Gly Lys Asn Cys Glu Leu Leu Leu Val Val 
                165                 170 


<210> 199
<211> 165
<212> PRT
<213> Homo sapiens

<400> 199
Asp Phe Ile Phe His Glu Lys Gln Glu Gly Phe Leu Cys Ala Gln His 
1               5                   10                  15      


Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu Leu 
            20                  25                  30          


Ala Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met Ala 
        35                  40                  45              


Glu Gly Gly Val Thr Ser Glu Glu Tyr Leu Ala Phe Leu Gln Gln Pro 
    50                  55                  60                  


Ser Glu Asn Met Asp Asp Thr Gly Phe Phe Ser Ile Gln Val Ile Ser 
65                  70                  75                  80  


Asn Ala Leu Lys Phe Trp Gly Leu Glu Ile Ile His Phe Asn Asn Pro 
                85                  90                  95      


Glu Tyr Gln Lys Leu Gly Ile Asp Pro Ile Asn Glu Arg Ser Phe Ile 
            100                 105                 110         


Cys Asn Tyr Lys Gln His Trp Phe Thr Ile Arg Lys Phe Gly Lys His 
        115                 120                 125             


Trp Phe Asn Leu Asn Ser Leu Leu Ala Gly Pro Glu Leu Ile Ser Asp 
    130                 135                 140                 


Thr Cys Leu Ala Asn Phe Leu Ala Arg Leu Gln Gln Gln Ala Tyr Ser 
145                 150                 155                 160 


Val Phe Val Val Lys 
                165 


<210> 200
<211> 419
<212> PRT
<213> Homo sapiens

<400> 200
Cys Arg Trp Thr Gln Gly Phe Val Phe Ser Glu Ser Glu Gly Ser Ala 
1               5                   10                  15      


Leu Glu Gln Phe Glu Gly Gly Pro Cys Ala Val Ile Ala Pro Val Gln 
            20                  25                  30          


Ala Phe Leu Leu Lys Lys Leu Leu Phe Ser Ser Glu Lys Ser Ser Trp 
        35                  40                  45              


Arg Asp Cys Ser Glu Glu Glu Gln Lys Glu Leu Leu Cys His Thr Leu 
    50                  55                  60                  


Cys Asp Ile Leu Glu Ser Ala Cys Cys Asp His Ser Gly Ser Tyr Cys 
65                  70                  75                  80  


Leu Val Ser Trp Leu Arg Gly Lys Thr Thr Glu Glu Thr Ala Ser Ile 
                85                  90                  95      


Ser Gly Ser Pro Ala Glu Ser Ser Cys Gln Val Glu His Ser Ser Ala 
            100                 105                 110         


Leu Ala Val Glu Glu Leu Gly Phe Glu Arg Phe His Ala Leu Ile Gln 
        115                 120                 125             


Lys Arg Ser Phe Arg Ser Leu Pro Glu Leu Lys Asp Ala Val Leu Asp 
    130                 135                 140                 


Gln Tyr Ser Met Trp Gly Asn Lys Phe Gly Val Leu Leu Phe Leu Tyr 
145                 150                 155                 160 


Ser Val Leu Leu Thr Lys Gly Ile Glu Asn Ile Lys Asn Glu Ile Glu 
                165                 170                 175     


Asp Ala Ser Glu Pro Leu Ile Asp Pro Val Tyr Gly His Gly Ser Gln 
            180                 185                 190         


Ser Leu Ile Asn Leu Leu Leu Thr Gly His Ala Val Ser Asn Val Trp 
        195                 200                 205             


Asp Gly Asp Arg Glu Cys Ser Gly Met Lys Leu Leu Gly Ile His Glu 
    210                 215                 220                 


Gln Ala Ala Val Gly Phe Leu Thr Leu Met Glu Ala Leu Arg Tyr Cys 
225                 230                 235                 240 


Lys Val Gly Ser Tyr Leu Lys Ser Pro Lys Phe Pro Ile Trp Ile Val 
                245                 250                 255     


Gly Ser Glu Thr His Leu Thr Val Phe Phe Ala Lys Asp Met Ala Leu 
            260                 265                 270         


Val Ala Pro Glu Ala Pro Ser Glu Gln Ala Arg Arg Val Phe Gln Thr 
        275                 280                 285             


Tyr Asp Pro Glu Asp Asn Gly Phe Ile Pro Asp Ser Leu Leu Glu Asp 
    290                 295                 300                 


Val Met Lys Ala Leu Asp Leu Val Ser Asp Pro Glu Tyr Ile Asn Leu 
305                 310                 315                 320 


Met Lys Asn Lys Leu Asp Pro Glu Gly Leu Gly Ile Ile Leu Leu Gly 
                325                 330                 335     


Pro Phe Leu Gln Glu Phe Phe Pro Asp Gln Gly Ser Ser Gly Pro Glu 
            340                 345                 350         


Ser Phe Thr Val Tyr His Tyr Asn Gly Leu Lys Gln Ser Asn Tyr Asn 
        355                 360                 365             


Glu Lys Val Met Tyr Val Glu Gly Thr Ala Val Val Met Gly Phe Glu 
    370                 375                 380                 


Asp Pro Met Leu Gln Thr Asp Asp Thr Pro Ile Lys Arg Cys Leu Gln 
385                 390                 395                 400 


Thr Lys Trp Pro Tyr Ile Glu Leu Leu Trp Thr Thr Asp Arg Ser Pro 
                405                 410                 415     


Ser Leu Asn 
            


<210> 201
<211> 356
<212> PRT
<213> Homo sapiens

<400> 201
Tyr Cys Val Lys Trp Ile Pro Trp Lys Gly Glu Gln Thr Pro Ile Ile 
1               5                   10                  15      


Thr Gln Ser Thr Asn Gly Pro Cys Pro Leu Leu Ala Ile Met Asn Ile 
            20                  25                  30          


Leu Phe Leu Gln Trp Lys Val Lys Leu Pro Pro Gln Lys Glu Val Ile 
        35                  40                  45              


Thr Ser Asp Glu Leu Met Ala His Leu Gly Asn Cys Leu Leu Ser Ile 
    50                  55                  60                  


Lys Pro Gln Glu Lys Ser Glu Gly Leu Gln Leu Asn Phe Gln Gln Asn 
65                  70                  75                  80  


Val Asp Asp Ala Met Thr Val Leu Pro Lys Leu Ala Thr Gly Leu Asp 
                85                  90                  95      


Val Asn Val Arg Phe Thr Gly Val Ser Asp Phe Glu Tyr Thr Pro Glu 
            100                 105                 110         


Cys Ser Val Phe Asp Leu Leu Gly Ile Pro Leu Tyr His Gly Trp Leu 
        115                 120                 125             


Val Asp Pro Gln Ser Pro Glu Ala Val Arg Ala Val Gly Lys Leu Ser 
    130                 135                 140                 


Tyr Asn Gln Leu Val Glu Arg Ile Ile Thr Cys Lys His Ser Ser Asp 
145                 150                 155                 160 


Thr Asn Leu Val Thr Glu Gly Leu Ile Ala Glu Gln Phe Leu Glu Thr 
                165                 170                 175     


Thr Ala Ala Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ala Ala 
            180                 185                 190         


Ala Lys Glu Gly Glu Leu Ser Val Phe Phe Arg Asn Asn His Phe Ser 
        195                 200                 205             


Thr Met Thr Lys His Lys Ser His Leu Tyr Leu Leu Val Thr Asp Gln 
    210                 215                 220                 


Gly Phe Leu Gln Glu Glu Gln Val Val Trp Glu Ser Leu His Asn Val 
225                 230                 235                 240 


Asp Gly Asp Ser Cys Phe Cys Asp Ser Asp Phe His Leu Ser His Ser 
                245                 250                 255     


Leu Gly Lys Gly Pro Gly Ala Glu Gly Gly Ser Gly Ser Pro Glu Thr 
            260                 265                 270         


Gln Leu Gln Val Asp Gln Asp Tyr Leu Ile Ala Leu Ser Leu Gln Gln 
        275                 280                 285             


Gln Gln Pro Arg Gly Pro Leu Gly Leu Thr Asp Leu Glu Leu Ala Gln 
    290                 295                 300                 


Gln Leu Gln Gln Glu Glu Tyr Gln Gln Gln Gln Ala Ala Gln Pro Val 
305                 310                 315                 320 


Arg Met Arg Thr Arg Val Leu Ser Leu Gln Gly Arg Gly Ala Thr Ser 
                325                 330                 335     


Gly Arg Pro Ala Gly Glu Arg Arg Gln Arg Pro Lys His Glu Ser Asp 
            340                 345                 350         


Cys Ile Leu Leu 
        355     


<210> 202
<211> 379
<212> PRT
<213> Homo sapiens

<400> 202
Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro Ile Ile 
1               5                   10                  15      


Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu Asn Val 
            20                  25                  30          


Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu Ile Ile 
        35                  40                  45              


Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu Asp Ala 
    50                  55                  60                  


Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu Gln Asn 
65                  70                  75                  80  


Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly Leu Asp 
                85                  90                  95      


Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr Pro Glu 
            100                 105                 110         


Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly Trp Leu 
        115                 120                 125             


Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser 
    130                 135                 140                 


Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn 
145                 150                 155                 160 


Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn 
                165                 170                 175     


Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr 
            180                 185                 190         


Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser 
        195                 200                 205             


Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln 
    210                 215                 220                 


Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val 
225                 230                 235                 240 


Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro 
                245                 250                 255     


Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln 
            260                 265                 270         


Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu 
        275                 280                 285             


Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala 
    290                 295                 300                 


Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln 
305                 310                 315                 320 


Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala 
                325                 330                 335     


Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser 
            340                 345                 350         


Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu 
        355                 360                 365             


Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
    370                 375                 


<210> 203
<211> 334
<212> PRT
<213> Homo sapiens

<400> 203
Phe Cys Cys Phe Asn Glu Glu Trp Lys Leu Gln Ser Phe Ser Phe Ser 
1               5                   10                  15      


Asn Thr Ala Ser Leu Lys Tyr Gly Ile Val Gln Asn Lys Gly Gly Pro 
            20                  25                  30          


Cys Gly Val Leu Ala Ala Val Gln Gly Cys Val Leu Gln Lys Leu Leu 
        35                  40                  45              


Phe Glu Gly Asp Ser Lys Ala Asp Cys Ala Gln Gly Leu Gln Pro Ser 
    50                  55                  60                  


Asp Ala His Arg Thr Arg Cys Leu Val Leu Ala Leu Ala Asp Ile Val 
65                  70                  75                  80  


Trp Arg Ala Gly Gly Arg Glu Arg Ala Val Val Ala Leu Ala Ser Arg 
                85                  90                  95      


Thr Gln Gln Phe Ser Pro Thr Gly Lys Tyr Lys Ala Asp Gly Val Leu 
            100                 105                 110         


Glu Thr Leu Thr Leu His Ser Leu Thr Cys Tyr Glu Asp Leu Val Thr 
        115                 120                 125             


Phe Leu Gln Gln Ser Ile His Gln Phe Glu Val Gly Pro Tyr Gly Cys 
    130                 135                 140                 


Ile Leu Leu Thr Leu Ser Ala Ile Leu Ser Arg Ser Thr Glu Leu Ile 
145                 150                 155                 160 


Arg Gln Asp Phe Asp Val Pro Thr Ser His Leu Ile Gly Ala His Gly 
                165                 170                 175     


Tyr Cys Thr Gln Glu Leu Val Asn Leu Leu Leu Thr Gly Lys Ala Val 
            180                 185                 190         


Ser Asn Val Phe Asn Asp Val Val Glu Leu Asp Ser Gly Asp Gly Asn 
        195                 200                 205             


Ile Thr Leu Leu Arg Gly Ile Ala Ala Arg Ser Asp Ile Gly Phe Leu 
    210                 215                 220                 


Ser Leu Phe Glu His Tyr Asn Met Cys Gln Val Gly Cys Phe Leu Lys 
225                 230                 235                 240 


Thr Pro Arg Phe Pro Ile Trp Val Val Cys Ser Glu Ser His Phe Ser 
                245                 250                 255     


Ile Leu Phe Ser Leu Gln Pro Gly Leu Leu Arg Asp Trp Arg Thr Glu 
            260                 265                 270         


Arg Leu Phe Asp Leu Tyr Tyr Tyr Asp Gly Leu Ala Asn Gln Gln Glu 
        275                 280                 285             


Gln Ile Arg Leu Thr Ile Asp Thr Thr Gln Thr Ile Ser Glu Asp Thr 
    290                 295                 300                 


Asp Asn Asp Leu Val Pro Pro Leu Glu Leu Cys Ile Arg Thr Lys Trp 
305                 310                 315                 320 


Lys Gly Ala Ser Val Asn Trp Asn Gly Ser Asp Pro Ile Leu 
                325                 330                 


<210> 204
<211> 167
<212> PRT
<213> Homo sapiens

<400> 204
Val Val Pro Gly Arg Leu Cys Pro Gln Phe Leu Gln Leu Ala Ser Ala 
1               5                   10                  15      


Asn Thr Ala Arg Gly Val Glu Thr Cys Gly Ile Leu Cys Gly Lys Leu 
            20                  25                  30          


Met Arg Asn Glu Phe Thr Ile Thr His Val Leu Ile Pro Lys Gln Ser 
        35                  40                  45              


Ala Gly Ser Asp Tyr Cys Asn Thr Glu Asn Glu Glu Glu Leu Phe Leu 
    50                  55                  60                  


Ile Gln Asp Gln Gln Gly Leu Ile Thr Leu Gly Trp Ile His Thr His 
65                  70                  75                  80  


Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His Cys 
                85                  90                  95      


Ser Tyr Gln Met Met Leu Pro Glu Ser Val Ala Ile Val Cys Ser Pro 
            100                 105                 110         


Lys Phe Gln Glu Thr Gly Phe Phe Lys Leu Thr Asp His Gly Leu Glu 
        115                 120                 125             


Glu Ile Ser Ser Cys Arg Gln Lys Gly Phe His Pro His Ser Lys Asp 
    130                 135                 140                 


Pro Pro Leu Phe Cys Ser Cys Ser His Val Thr Val Val Asp Arg Ala 
145                 150                 155                 160 


Val Thr Ile Thr Asp Leu Arg 
                165         


<210> 205
<211> 200
<212> PRT
<213> Homo sapiens

<400> 205
Val Ala Val Ser Ser Asn Val Leu Phe Leu Leu Asp Phe His Ser His 
1               5                   10                  15      


Leu Thr Arg Ser Glu Val Val Gly Tyr Leu Gly Gly Arg Trp Asp Val 
            20                  25                  30          


Asn Ser Gln Met Leu Thr Val Leu Arg Ala Phe Pro Cys Arg Ser Arg 
        35                  40                  45              


Leu Gly Asp Ala Glu Thr Ala Ala Ala Ile Glu Glu Glu Ile Tyr Gln 
    50                  55                  60                  


Ser Leu Phe Leu Arg Gly Leu Ser Leu Val Gly Trp Tyr His Ser His 
65                  70                  75                  80  


Pro His Ser Pro Ala Leu Pro Ser Leu Gln Asp Ile Asp Ala Gln Met 
                85                  90                  95      


Asp Tyr Gln Leu Arg Leu Gln Gly Ser Ser Asn Gly Phe Gln Pro Cys 
            100                 105                 110         


Leu Ala Leu Leu Cys Ser Pro Tyr Tyr Ser Gly Asn Pro Gly Pro Glu 
        115                 120                 125             


Ser Lys Ile Ser Pro Phe Trp Val Met Pro Pro Pro Glu Met Leu Leu 
    130                 135                 140                 


Val Glu Phe Tyr Lys Gly Ser Pro Asp Leu Val Arg Leu Gln Glu Pro 
145                 150                 155                 160 


Trp Ser Gln Glu His Thr Tyr Leu Asp Lys Leu Lys Ile Ser Leu Ala 
                165                 170                 175     


Ser Arg Thr Pro Lys Asp Gln Ser Leu Cys His Val Leu Glu Gln Val 
            180                 185                 190         


Cys Gly Val Leu Lys Gln Gly Ser 
        195                 200 


<210> 206
<211> 201
<212> PRT
<213> Homo sapiens

<400> 206
Ala Leu Ala Tyr Val Lys Met Cys Leu His Ala Ala Arg Tyr Pro His 
1               5                   10                  15      


Ala Ala Val Asn Gly Leu Phe Leu Ala Pro Ala Pro Arg Ser Gly Glu 
            20                  25                  30          


Cys Leu Cys Leu Thr Asp Cys Val Pro Leu Phe His Ser His Leu Ala 
        35                  40                  45              


Leu Ser Val Met Leu Glu Val Ala Leu Asn Gln Val Asp Val Trp Gly 
    50                  55                  60                  


Ala Gln Ala Gly Leu Val Val Ala Gly Tyr Tyr His Ala Asn Ala Ala 
65                  70                  75                  80  


Val Asn Asp Gln Ser Pro Gly Pro Leu Ala Leu Lys Ile Ala Gly Arg 
                85                  90                  95      


Ile Ala Glu Phe Phe Pro Asp Ala Val Leu Ile Met Leu Asp Asn Gln 
            100                 105                 110         


Lys Leu Val Pro Gln Pro Arg Val Pro Pro Val Ile Val Leu Glu Asn 
        115                 120                 125             


Gln Gly Leu Arg Trp Val Pro Lys Asp Lys Asn Leu Val Met Trp Arg 
    130                 135                 140                 


Asp Trp Glu Glu Ser Arg Gln Met Val Gly Ala Leu Leu Glu Asp Arg 
145                 150                 155                 160 


Ala His Gln His Leu Val Asp Phe Asp Cys His Leu Asp Asp Ile Arg 
                165                 170                 175     


Gln Asp Trp Thr Asn Gln Arg Leu Asn Thr Gln Ile Thr Gln Trp Val 
            180                 185                 190         


Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200     


<210> 207
<211> 281
<212> PRT
<213> Homo sapiens

<400> 207
Gln Val Tyr Ile Ser Ser Leu Ala Leu Leu Lys Met Leu Lys His Gly 
1               5                   10                  15      


Arg Ala Gly Val Pro Met Glu Val Met Gly Leu Met Leu Gly Glu Phe 
            20                  25                  30          


Val Asp Asp Tyr Thr Val Arg Val Ile Asp Val Phe Ala Met Pro Gln 
        35                  40                  45              


Ser Gly Thr Gly Val Ser Val Glu Ala Val Asp Pro Val Phe Gln Ala 
    50                  55                  60                  


Lys Met Leu Asp Met Leu Lys Gln Thr Gly Arg Pro Glu Met Val Val 
65                  70                  75                  80  


Gly Trp Tyr His Ser His Pro Gly Phe Gly Cys Trp Leu Ser Gly Val 
                85                  90                  95      


Asp Ile Asn Thr Gln Gln Ser Phe Glu Ala Leu Ser Glu Arg Ala Val 
            100                 105                 110         


Ala Val Val Val Asp Pro Ile Gln Ser Val Lys Gly Lys Val Val Ile 
        115                 120                 125             


Asp Ala Phe Arg Leu Ile Asn Ala Asn Met Met Val Leu Gly His Glu 
    130                 135                 140                 


Pro Arg Gln Thr Thr Ser Asn Leu Gly His Leu Asn Lys Pro Ser Ile 
145                 150                 155                 160 


Gln Ala Leu Ile His Gly Leu Asn Arg His Tyr Tyr Ser Ile Thr Ile 
                165                 170                 175     


Asn Tyr Arg Lys Asn Glu Leu Glu Gln Lys Met Leu Leu Asn Leu His 
            180                 185                 190         


Lys Lys Ser Trp Met Glu Gly Leu Thr Leu Gln Asp Tyr Ser Glu His 
        195                 200                 205             


Cys Lys His Asn Glu Ser Val Val Lys Glu Met Leu Glu Leu Ala Lys 
    210                 215                 220                 


Asn Tyr Asn Lys Ala Val Glu Glu Glu Asp Lys Met Thr Pro Glu Gln 
225                 230                 235                 240 


Leu Ala Ile Lys Asn Val Gly Lys Gln Asp Pro Lys Arg His Leu Glu 
                245                 250                 255     


Glu His Val Asp Val Leu Met Thr Ser Asn Ile Val Gln Cys Leu Ala 
            260                 265                 270         


Ala Met Leu Asp Thr Val Val Phe Lys 
        275                 280     


<210> 208
<211> 253
<212> PRT
<213> Homo sapiens

<400> 208
Gln Val Lys Val Ala Ser Glu Ala Leu Leu Ile Met Asp Leu His Ala 
1               5                   10                  15      


His Val Ser Met Ala Glu Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser 
            20                  25                  30          


Glu Val Asp Lys Val Val Glu Val Cys Ala Ala Glu Pro Cys Asn Ser 
        35                  40                  45              


Leu Ser Thr Gly Leu Gln Cys Glu Met Asp Pro Val Ser Gln Thr Gln 
    50                  55                  60                  


Ala Ser Glu Thr Leu Ala Val Arg Gly Phe Ser Val Ile Gly Trp Tyr 
65                  70                  75                  80  


His Ser His Pro Ala Phe Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp 
                85                  90                  95      


Thr Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe 
            100                 105                 110         


Ile Gly Met Ile Val Ser Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr 
        115                 120                 125             


Ser Gln Ile Thr Cys Leu Val Ile Ser Glu Glu Ile Ser Pro Asp Gly 
    130                 135                 140                 


Ser Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln Gln Met Leu Glu Glu 
145                 150                 155                 160 


Pro Gln Trp Gly Leu Val Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys 
                165                 170                 175     


Tyr Arg Leu Ser His Ser Ser Val Pro Met Asp Lys Ile Phe Arg Arg 
            180                 185                 190         


Asp Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu Glu Cys Met Arg Lys 
        195                 200                 205             


Thr Leu Ser Lys Val Thr Asn Cys Phe Met Ala Glu Glu Phe Leu Thr 
    210                 215                 220                 


Glu Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys Ser Asn Gln Glu Asn 
225                 230                 235                 240 


Gly Val Thr Glu Glu Asn Cys Thr Lys Glu Leu Leu Met 
                245                 250             


<210> 209
<211> 404
<212> PRT
<213> Homo sapiens

<400> 209
Ala Val Cys Phe His Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe 
1               5                   10                  15      


Leu Leu Gly Glu Val Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser 
            20                  25                  30          


Gln Ile Ser Asn Thr Glu Phe Leu Gln Val Ile Glu Ile His Asn His 
        35                  40                  45              


Gln Pro Cys Ser Lys Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val 
    50                  55                  60                  


Asn Glu Glu Ser Leu Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val 
65                  70                  75                  80  


Ile Gly Trp Tyr Arg Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr 
                85                  90                  95      


Arg Glu Gln Val Leu His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro 
            100                 105                 110         


Asp Leu Val Phe Leu Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser 
        115                 120                 125             


Thr His Ala Leu Glu Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn 
    130                 135                 140                 


Gln Arg Ile Ser Leu Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln 
145                 150                 155                 160 


Glu Tyr Lys Val Ser Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys 
                165                 170                 175     


Val Ile Lys Glu His Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met 
            180                 185                 190         


Lys Asp Ile Arg Ala Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys 
        195                 200                 205             


Val Gln Ala Val Cys Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu 
    210                 215                 220                 


Ser Cys Gln Ala Glu Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg 
225                 230                 235                 240 


Lys Asn Glu Lys Glu Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser 
                245                 250                 255     


Arg Gln Met Pro Ser Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met 
            260                 265                 270         


Pro Ser Ser Gly Phe Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala 
        275                 280                 285             


Glu Ala Ser Asp Pro Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn 
    290                 295                 300                 


Gln Glu Ser Thr Leu Ser His Ser Arg Met Glu Arg Ser Val Phe Met 
305                 310                 315                 320 


Pro Arg Pro Gln Ala Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala 
                325                 330                 335     


Gly Leu Lys Tyr Pro Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg 
            340                 345                 350         


Ala Ala Gly Asp Ser Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn 
        355                 360                 365             


Leu Ile Asp Pro Thr Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys 
    370                 375                 380                 


Asp Ser Arg Pro Met Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln 
385                 390                 395                 400 


Thr Ser Gln Ile 
                


<210> 210
<211> 526
<212> PRT
<213> Homo sapiens

<400> 210
Phe Asn Pro Arg Thr Gly Gln Leu Phe Leu Lys Ile Ile His Thr Ser 
1               5                   10                  15      


Val Trp Ala Gly Gln Lys Arg Leu Gly Gln Leu Ala Lys Trp Lys Thr 
            20                  25                  30          


Ala Glu Glu Val Ala Ala Leu Ile Arg Ser Leu Pro Val Glu Glu Gln 
        35                  40                  45              


Pro Lys Gln Ile Ile Val Thr Arg Lys Gly Met Leu Asp Pro Leu Glu 
    50                  55                  60                  


Val His Leu Leu Asp Phe Pro Asn Ile Val Ile Lys Gly Ser Glu Leu 
65                  70                  75                  80  


Gln Leu Pro Phe Gln Ala Cys Leu Lys Val Glu Lys Phe Gly Asp Leu 
                85                  90                  95      


Ile Leu Lys Ala Thr Glu Pro Gln Met Val Leu Phe Asn Leu Tyr Asp 
            100                 105                 110         


Asp Trp Leu Lys Thr Ile Ser Ser Tyr Thr Ala Phe Ser Arg Leu Ile 
        115                 120                 125             


Leu Ile Leu Arg Ala Leu His Val Asn Asn Asp Arg Ala Lys Val Ile 
    130                 135                 140                 


Leu Lys Pro Asp Lys Thr Thr Ile Thr Glu Pro His His Ile Trp Pro 
145                 150                 155                 160 


Thr Leu Thr Asp Glu Glu Trp Ile Lys Val Glu Val Gln Leu Lys Asp 
                165                 170                 175     


Leu Ile Leu Ala Asp Tyr Gly Lys Lys Asn Asn Val Asn Val Ala Ser 
            180                 185                 190         


Leu Thr Gln Ser Glu Ile Arg Asp Ile Ile Leu Gly Met Glu Ile Ser 
        195                 200                 205             


Ala Pro Ser Gln Gln Arg Gln Gln Ile Ala Glu Ile Glu Lys Gln Thr 
    210                 215                 220                 


Lys Glu Gln Ser Gln Leu Thr Ala Thr Gln Thr Arg Thr Val Asn Lys 
225                 230                 235                 240 


His Gly Asp Glu Ile Ile Thr Ser Thr Thr Ser Asn Tyr Glu Thr Gln 
                245                 250                 255     


Thr Phe Ser Ser Lys Thr Glu Trp Arg Val Arg Ala Ile Ser Ala Ala 
            260                 265                 270         


Asn Leu His Leu Arg Thr Asn His Ile Tyr Val Ser Ser Asp Asp Ile 
        275                 280                 285             


Lys Glu Thr Gly Tyr Thr Tyr Ile Leu Pro Lys Asn Val Leu Lys Lys 
    290                 295                 300                 


Phe Ile Cys Ile Ser Asp Leu Arg Ala Gln Ile Ala Gly Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Ser Pro Pro Asp Asn Pro Gln Val Lys Glu Ile Arg Cys Ile 
                325                 330                 335     


Val Met Val Pro Gln Trp Gly Thr His Gln Thr Val His Leu Pro Gly 
            340                 345                 350         


Gln Leu Pro Gln His Glu Tyr Leu Lys Glu Met Glu Pro Leu Gly Trp 
        355                 360                 365             


Ile His Thr Gln Pro Asn Glu Ser Pro Gln Leu Ser Pro Gln Asp Val 
    370                 375                 380                 


Thr Thr His Ala Lys Ile Met Ala Asp Asn Pro Ser Trp Asp Gly Glu 
385                 390                 395                 400 


Lys Thr Ile Ile Ile Thr Cys Ser Phe Thr Pro Gly Ser Cys Thr Leu 
                405                 410                 415     


Thr Ala Tyr Lys Leu Thr Pro Ser Gly Tyr Glu Trp Gly Arg Gln Asn 
            420                 425                 430         


Thr Asp Lys Gly Asn Asn Pro Lys Gly Tyr Leu Pro Ser His Tyr Glu 
        435                 440                 445             


Arg Val Gln Met Leu Leu Ser Asp Arg Phe Leu Gly Phe Phe Met Val 
    450                 455                 460                 


Pro Ala Gln Ser Ser Trp Asn Tyr Asn Phe Met Gly Val Arg His Asp 
465                 470                 475                 480 


Pro Asn Met Lys Tyr Glu Leu Gln Leu Ala Asn Pro Lys Glu Phe Tyr 
                485                 490                 495     


His Glu Val His Arg Pro Ser His Phe Leu Asn Phe Ala Leu Leu Gln 
            500                 505                 510         


Glu Gly Glu Val Tyr Ser Ala Asp Arg Glu Asp Leu Tyr Ala 
        515                 520                 525     


<210> 211
<211> 400
<212> PRT
<213> Homo sapiens

<400> 211
Gln Pro Ser Ala Ile Thr Leu Asn Arg Gln Lys Tyr Arg His Val Asp 
1               5                   10                  15      


Asn Ile Met Phe Glu Asn His Thr Val Ala Asp Arg Phe Leu Asp Phe 
            20                  25                  30          


Trp Arg Lys Thr Gly Asn Gln His Phe Gly Tyr Leu Tyr Gly Arg Tyr 
        35                  40                  45              


Thr Glu His Lys Asp Ile Pro Leu Gly Ile Arg Ala Glu Val Ala Ala 
    50                  55                  60                  


Ile Tyr Glu Pro Pro Gln Ile Gly Thr Gln Asn Ser Leu Glu Leu Leu 
65                  70                  75                  80  


Glu Asp Pro Lys Ala Glu Val Val Asp Glu Ile Ala Ala Lys Leu Gly 
                85                  90                  95      


Leu Arg Lys Val Gly Trp Ile Phe Thr Asp Leu Val Ser Glu Asp Thr 
            100                 105                 110         


Arg Lys Gly Thr Val Arg Tyr Ser Arg Asn Lys Asp Thr Tyr Phe Leu 
        115                 120                 125             


Ser Ser Glu Glu Cys Ile Thr Ala Gly Asp Phe Gln Asn Lys His Pro 
    130                 135                 140                 


Asn Met Cys Arg Leu Ser Pro Asp Gly His Phe Gly Ser Lys Phe Val 
145                 150                 155                 160 


Thr Ala Val Ala Thr Gly Gly Pro Asp Asn Gln Val His Phe Glu Gly 
                165                 170                 175     


Tyr Gln Val Ser Asn Gln Cys Met Ala Leu Val Arg Asp Glu Cys Leu 
            180                 185                 190         


Leu Pro Cys Lys Asp Ala Pro Glu Leu Gly Tyr Ala Lys Glu Ser Ser 
        195                 200                 205             


Ser Glu Gln Tyr Val Pro Asp Val Phe Tyr Lys Asp Val Asp Lys Phe 
    210                 215                 220                 


Gly Asn Glu Ile Thr Gln Leu Ala Arg Pro Leu Pro Val Glu Tyr Leu 
225                 230                 235                 240 


Ile Ile Asp Ile Thr Thr Thr Phe Pro Lys Asp Pro Val Tyr Thr Phe 
                245                 250                 255     


Ser Ile Ser Gln Asn Pro Phe Pro Ile Glu Asn Arg Asp Val Leu Gly 
            260                 265                 270         


Glu Thr Gln Asp Phe His Ser Leu Ala Thr Tyr Leu Ser Gln Asn Thr 
        275                 280                 285             


Ser Ser Val Phe Leu Asp Thr Ile Ser Asp Phe His Leu Leu Leu Phe 
    290                 295                 300                 


Leu Val Thr Asn Glu Val Met Pro Leu Gln Asp Ser Ile Ser Leu Leu 
305                 310                 315                 320 


Leu Glu Ala Val Arg Thr Arg Asn Glu Glu Leu Ala Gln Thr Trp Lys 
                325                 330                 335     


Arg Ser Glu Gln Trp Ala Thr Ile Glu Gln Leu Cys Ser Thr Val Gly 
            340                 345                 350         


Gly Gln Leu Pro Gly Leu His Glu Tyr Gly Ala Val Gly Gly Ser Thr 
        355                 360                 365             


His Thr Ala Thr Ala Ala Met Trp Ala Cys Gln His Cys Thr Phe Met 
    370                 375                 380                 


Asn Gln Pro Gly Thr Gly His Cys Glu Met Cys Ser Leu Pro Arg Thr 
385                 390                 395                 400 


<210> 212
<211> 203
<212> PRT
<213> Homo sapiens

<400> 212
Thr Gln Ala Tyr Cys Lys Met Val Leu His Gly Ala Lys Tyr Pro His 
1               5                   10                  15      


Cys Ala Val Asn Gly Leu Leu Val Ala Glu Lys Gln Lys Pro Arg Lys 
            20                  25                  30          


Glu His Leu Pro Leu Gly Gly Pro Gly Ala His His Thr Leu Phe Val 
        35                  40                  45              


Asp Cys Ile Pro Leu Phe His Gly Thr Leu Ala Leu Ala Pro Met Leu 
    50                  55                  60                  


Glu Val Ala Leu Thr Leu Ile Asp Ser Trp Cys Lys Asp His Ser Tyr 
65                  70                  75                  80  


Val Ile Ala Gly Tyr Tyr Gln Ala Asn Glu Arg Val Lys Asp Ala Ser 
                85                  90                  95      


Pro Asn Gln Val Ala Glu Lys Val Ala Ser Arg Ile Ala Glu Gly Phe 
            100                 105                 110         


Ser Asp Thr Ala Leu Ile Met Val Asp Asn Thr Lys Phe Thr Met Asp 
        115                 120                 125             


Cys Val Ala Pro Thr Ile His Val Tyr Glu His His Glu Asn Arg Trp 
    130                 135                 140                 


Arg Cys Arg Asp Pro His His Asp Tyr Cys Glu Asp Trp Pro Glu Ala 
145                 150                 155                 160 


Gln Arg Ile Ser Ala Ser Leu Leu Asp Ser Arg Ser Tyr Glu Thr Leu 
                165                 170                 175     


Val Asp Phe Asp Asn His Leu Asp Asp Ile Arg Asn Asp Trp Thr Asn 
            180                 185                 190         


Pro Glu Ile Asn Lys Ala Val Leu His Leu Cys 
        195                 200             


<210> 213
<211> 398
<212> PRT
<213> Homo sapiens

<400> 213
Gly Phe Val Leu Gly Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser 
1               5                   10                  15      


Asp Thr Glu Gly Phe Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn 
            20                  25                  30          


Ser Ile Thr Asp Ser Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile 
        35                  40                  45              


Asp Ile Gln Lys Tyr Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn 
    50                  55                  60                  


Ser Ser Gly Glu Val Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn 
65                  70                  75                  80  


Val Lys Lys Asn Val Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp 
                85                  90                  95      


Gln Ile Met Thr Phe Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu 
            100                 105                 110         


His Phe Ser Asn Gln Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile 
        115                 120                 125             


Ile Thr Glu Ser Cys Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys 
    130                 135                 140                 


Pro Gln Lys Gly Leu Phe His Arg Val Pro Leu Val Val Ala Asn Leu 
145                 150                 155                 160 


Gly Met Ser Glu Gln Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met 
                165                 170                 175     


Ser Thr Gly Phe Ser Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe 
            180                 185                 190         


Glu Glu Asp Gly Ser Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr 
        195                 200                 205             


Ala Ser Leu Gln Glu Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp 
    210                 215                 220                 


Ser Glu Gln Ala Val Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys 
225                 230                 235                 240 


Arg Glu Ile Glu Lys Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu 
                245                 250                 255     


Lys Asn Ile Gln Lys Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala 
            260                 265                 270         


Leu Arg Thr Phe Phe Pro Asn Ser Glu Phe Leu His Ser Cys Val Met 
        275                 280                 285             


Ser Leu Lys Asn Arg His Val Ser Lys Ser Ser Cys Asn Tyr Asn His 
    290                 295                 300                 


His Leu Asp Val Val Asp Asn Leu Thr Leu Met Val Glu His Thr Asp 
305                 310                 315                 320 


Ile Pro Glu Ala Ser Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys 
                325                 330                 335     


Ala Leu Asp Leu Asp Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


Asp Thr Gln Asp Lys Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln 
        355                 360                 365             


Asp Lys Ala Ser Lys Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu 
    370                 375                 380                 


Lys Met Lys Gly Phe Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
385                 390                 395             


<210> 214
<211> 168
<212> PRT
<213> Homo sapiens

<400> 214
Val Val Leu Pro Glu Asp Leu Cys His Lys Phe Leu Gln Leu Ala Glu 
1               5                   10                  15      


Ser Asn Thr Val Arg Gly Ile Glu Thr Cys Gly Ile Leu Cys Gly Lys 
            20                  25                  30          


Leu Thr His Asn Glu Phe Thr Ile Thr His Val Ile Val Pro Lys Gln 
        35                  40                  45              


Ser Ala Gly Pro Asp Tyr Cys Asp Met Glu Asn Val Glu Glu Leu Phe 
    50                  55                  60                  


Asn Val Gln Asp Gln His Asp Leu Leu Thr Leu Gly Trp Ile His Thr 
65                  70                  75                  80  


His Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His 
                85                  90                  95      


Cys Ser Tyr Gln Leu Met Leu Pro Glu Ala Ile Ala Ile Val Cys Ser 
            100                 105                 110         


Pro Lys His Lys Asp Thr Gly Ile Phe Arg Leu Thr Asn Ala Gly Met 
        115                 120                 125             


Leu Glu Val Ser Ala Cys Lys Lys Lys Gly Phe His Pro His Thr Lys 
    130                 135                 140                 


Glu Pro Arg Leu Phe Ser Ile Cys Lys His Val Leu Val Lys Asp Ile 
145                 150                 155                 160 


Lys Ile Ile Val Leu Asp Leu Arg 
                165             


<210> 215
<211> 287
<212> PRT
<213> Homo sapiens

<400> 215
Val Ala Leu His Pro Leu Val Ile Leu Asn Ile Ser Asp His Trp Ile 
1               5                   10                  15      


Arg Met Arg Ser Gln Glu Gly Arg Pro Val Gln Val Ile Gly Ala Leu 
            20                  25                  30          


Ile Gly Lys Gln Glu Gly Arg Asn Ile Glu Val Met Asn Ser Phe Glu 
        35                  40                  45              


Leu Leu Ser His Thr Val Glu Glu Lys Ile Ile Ile Asp Lys Glu Tyr 
    50                  55                  60                  


Tyr Tyr Thr Lys Glu Glu Gln Phe Lys Gln Val Phe Lys Glu Leu Glu 
65                  70                  75                  80  


Phe Leu Gly Trp Tyr Thr Thr Gly Gly Pro Pro Asp Pro Ser Asp Ile 
                85                  90                  95      


His Val His Lys Gln Val Cys Glu Ile Ile Glu Ser Pro Leu Phe Leu 
            100                 105                 110         


Lys Leu Asn Pro Met Thr Lys His Thr Asp Leu Pro Val Ser Val Phe 
        115                 120                 125             


Glu Ser Val Ile Asp Ile Ile Asn Gly Glu Ala Thr Met Leu Phe Ala 
    130                 135                 140                 


Glu Leu Thr Tyr Thr Leu Ala Thr Glu Glu Ala Glu Arg Ile Gly Val 
145                 150                 155                 160 


Asp His Val Ala Arg Met Thr Ala Thr Gly Ser Gly Glu Asn Ser Thr 
                165                 170                 175     


Val Ala Glu His Leu Ile Ala Gln His Ser Ala Ile Lys Met Leu His 
            180                 185                 190         


Ser Arg Val Lys Leu Ile Leu Glu Tyr Val Lys Ala Ser Glu Ala Gly 
        195                 200                 205             


Glu Val Pro Phe Asn His Glu Ile Leu Arg Glu Ala Tyr Ala Leu Cys 
    210                 215                 220                 


His Cys Leu Pro Val Leu Ser Thr Asp Lys Phe Lys Thr Asp Phe Tyr 
225                 230                 235                 240 


Asp Gln Cys Asn Asp Val Gly Leu Met Ala Tyr Leu Gly Thr Ile Thr 
                245                 250                 255     


Lys Thr Cys Asn Thr Met Asn Gln Phe Val Asn Lys Phe Asn Val Leu 
            260                 265                 270         


Tyr Asp Arg Gln Gly Ile Gly Arg Arg Met Arg Gly Leu Phe Phe 
        275                 280                 285         


<210> 216
<211> 266
<212> PRT
<213> Homo sapiens

<400> 216
Val Arg Leu His Pro Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu 
1               5                   10                  15      


Arg Arg Asn Glu Gly Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr 
            20                  25                  30          


Val Asp Lys His Ser Val Glu Val Thr Asn Cys Phe Ser Val Pro His 
        35                  40                  45              


Asn Glu Ser Glu Asp Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn 
    50                  55                  60                  


Met Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly 
65                  70                  75                  80  


Trp Tyr Ala Thr Gly His Asp Ile Thr Glu His Ser Val Leu Ile His 
                85                  90                  95      


Glu Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp 
            100                 105                 110         


Thr Ser Leu Gln Asn Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr 
        115                 120                 125             


Leu Met Gly Val Pro Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu 
    130                 135                 140                 


Thr Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu 
145                 150                 155                 160 


Ile Met Lys Thr Cys Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser 
                165                 170                 175     


Asp Leu Gln Gln Val Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu 
            180                 185                 190         


Ser Thr Val Leu Gln Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser 
        195                 200                 205             


Ala Asp Asn Thr Val Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val 
    210                 215                 220                 


Pro Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile 
225                 230                 235                 240 


Asn Asp Leu Leu Met Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln 
                245                 250                 255     


Ile Ala Leu Asn Glu Lys Leu Val Asn Leu 
            260                 265     


<210> 217
<211> 316
<212> PRT
<213> Homo sapiens

<400> 217
Val Val Val His Pro Leu Val Leu Leu Ser Val Val Asp His Phe Asn 
1               5                   10                  15      


Arg Ile Gly Lys Val Gly Asn Gln Lys Arg Val Val Gly Val Leu Leu 
            20                  25                  30          


Gly Ser Trp Gln Lys Lys Val Leu Asp Val Ser Asn Ser Phe Ala Val 
        35                  40                  45              


Pro Phe Asp Glu Asp Asp Lys Asp Asp Ser Val Trp Phe Leu Asp His 
    50                  55                  60                  


Asp Tyr Leu Glu Asn Met Tyr Gly Met Phe Lys Lys Val Asn Ala Arg 
65                  70                  75                  80  


Glu Arg Ile Val Gly Trp Tyr His Thr Gly Pro Lys Leu His Lys Asn 
                85                  90                  95      


Asp Ile Ala Ile Asn Glu Leu Met Lys Arg Tyr Cys Pro Asn Ser Val 
            100                 105                 110         


Leu Val Ile Ile Asp Val Lys Pro Lys Asp Leu Gly Leu Pro Thr Glu 
        115                 120                 125             


Ala Tyr Ile Ser Val Glu Glu Val His Asp Asp Gly Thr Pro Thr Ser 
    130                 135                 140                 


Lys Thr Phe Glu His Val Thr Ser Glu Ile Gly Ala Glu Glu Ala Glu 
145                 150                 155                 160 


Glu Val Gly Val Glu His Leu Leu Arg Asp Ile Lys Asp Thr Thr Val 
                165                 170                 175     


Gly Thr Leu Ser Gln Arg Ile Thr Asn Gln Val His Gly Leu Lys Gly 
            180                 185                 190         


Leu Asn Ser Lys Leu Leu Asp Ile Arg Ser Tyr Leu Glu Lys Val Ala 
        195                 200                 205             


Thr Gly Lys Leu Pro Ile Asn His Gln Ile Ile Tyr Gln Leu Gln Asp 
    210                 215                 220                 


Val Phe Asn Leu Leu Pro Asp Val Ser Leu Gln Glu Phe Val Lys Ala 
225                 230                 235                 240 


Phe Tyr Leu Lys Thr Asn Asp Gln Met Val Val Val Tyr Leu Ala Ser 
                245                 250                 255     


Leu Ile Arg Ser Val Val Ala Leu His Asn Leu Ile Asn Asn Lys Ile 
            260                 265                 270         


Ala Asn Arg Asp Ala Glu Lys Lys Glu Gly Gln Glu Lys Glu Glu Ser 
        275                 280                 285             


Lys Lys Asp Arg Lys Glu Asp Lys Glu Lys Asp Lys Asp Lys Glu Lys 
    290                 295                 300                 


Ser Asp Val Lys Lys Glu Glu Lys Lys Glu Lys Lys 
305                 310                 315     


<210> 218
<211> 314
<212> PRT
<213> Homo sapiens

<400> 218
Val Gln Ile Asp Gly Leu Val Val Leu Lys Ile Ile Lys His Tyr Gln 
1               5                   10                  15      


Glu Glu Gly Gln Gly Thr Glu Val Val Gln Gly Val Leu Leu Gly Leu 
            20                  25                  30          


Val Val Glu Asp Arg Leu Glu Ile Thr Asn Cys Phe Pro Phe Pro Gln 
        35                  40                  45              


His Thr Glu Asp Asp Ala Asp Phe Asp Glu Val Gln Tyr Gln Met Glu 
    50                  55                  60                  


Met Met Arg Ser Leu Arg His Val Asn Ile Asp His Leu His Val Gly 
65                  70                  75                  80  


Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe Val Thr Arg Ala Leu Leu 
                85                  90                  95      


Asp Ser Gln Phe Ser Tyr Gln His Ala Ile Glu Glu Ser Val Val Leu 
            100                 105                 110         


Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly Ser Leu Ser Leu Lys Ala 
        115                 120                 125             


Tyr Arg Leu Thr Pro Lys Leu Met Glu Val Cys Lys Glu Lys Asp Phe 
    130                 135                 140                 


Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile Thr Phe Glu Tyr Met Phe 
145                 150                 155                 160 


Glu Glu Val Pro Ile Val Ile Lys Asn Ser His Leu Ile Asn Val Leu 
                165                 170                 175     


Met Trp Glu Leu Glu Lys Lys Ser Ala Val Ala Asp Lys His Glu Leu 
            180                 185                 190         


Leu Ser Leu Ala Ser Ser Asn His Leu Gly Lys Asn Leu Gln Leu Leu 
        195                 200                 205             


Met Asp Arg Val Asp Glu Met Ser Gln Asp Ile Val Lys Tyr Asn Thr 
    210                 215                 220                 


Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln Gln Lys His Gln Tyr Gln 
225                 230                 235                 240 


Gln Arg Arg Gln Gln Glu Asn Met Gln Arg Gln Ser Arg Gly Glu Pro 
                245                 250                 255     


Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu Phe Lys Pro Pro Gln Pro 
            260                 265                 270         


Pro Ala Arg Met Asp Ser Leu Leu Ile Ala Gly Gln Ile Asn Thr Tyr 
        275                 280                 285             


Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln Asn Leu Gly Lys Leu Phe 
    290                 295                 300                 


Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
305                 310                 


<210> 219
<211> 281
<212> PRT
<213> Homo sapiens

<400> 219
Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys Met Val Met His Ala 
1               5                   10                  15      


Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu Met Leu Gly Lys Val 
            20                  25                  30          


Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe Ala Leu Pro Val Glu 
        35                  40                  45              


Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala Ala Tyr Glu Tyr Met 
    50                  55                  60                  


Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly Arg Leu Glu Asn Ala 
65                  70                  75                  80  


Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly Cys Trp Leu Ser Gly 
                85                  90                  95      


Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln Phe Gln Glu Pro Phe 
            100                 105                 110         


Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile Ser Ala Gly Lys Val 
        115                 120                 125             


Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly Tyr Lys Pro Pro Asp 
    130                 135                 140                 


Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu Asn Lys Ile Glu Asp 
145                 150                 155                 160 


Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu Glu Val Ser Tyr Phe 
                165                 170                 175     


Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu Leu Trp Asn Lys Tyr 
            180                 185                 190         


Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu Thr Asn Ala Asp Tyr 
        195                 200                 205             


Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys Leu Glu Gln Ser Glu 
    210                 215                 220                 


Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly Leu Glu Thr His Asp 
225                 230                 235                 240 


Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr Arg Asp Ser Cys Lys 
                245                 250                 255     


Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser Gln Val Ile Lys Asp 
            260                 265                 270         


Lys Leu Phe Asn Gln Ile Asn Ile Ser 
        275                 280     


<210> 220
<211> 305
<212> PRT
<213> Homo sapiens

<400> 220
Val His Leu Glu Ser Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu 
1               5                   10                  15      


Ser Thr Glu Lys Glu Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn 
            20                  25                  30          


Asp Asp Thr Arg Ser Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met 
        35                  40                  45              


Arg Thr Val Ala Glu Lys Val Asp Ala Val Arg Ile Val His Ile His 
    50                  55                  60                  


Ser Val Ile Ile Leu Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu 
65                  70                  75                  80  


Ile Ser Pro Glu Gln Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu 
                85                  90                  95      


Ala Glu Leu Thr Gly Arg Pro Met Arg Val Val Gly Trp Tyr His Ser 
            100                 105                 110         


His Pro His Ile Thr Val Trp Pro Ser His Val Asp Val Arg Thr Gln 
        115                 120                 125             


Ala Met Tyr Gln Met Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser 
    130                 135                 140                 


Cys Phe Ile Glu Asp Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr 
145                 150                 155                 160 


Cys Phe Gln Ser Ile Gln Ala Gln Lys Ser Ser Glu Ser Leu His Gly 
                165                 170                 175     


Pro Arg Asp Phe Trp Ser Ser Ser Gln His Ile Ser Ile Glu Gly Gln 
            180                 185                 190         


Lys Glu Glu Glu Arg Tyr Glu Arg Ile Glu Ile Pro Ile His Ile Val 
        195                 200                 205             


Pro His Val Thr Ile Gly Lys Val Cys Leu Glu Ser Ala Val Glu Leu 
    210                 215                 220                 


Pro Lys Ile Leu Cys Gln Glu Glu Gln Asp Ala Tyr Arg Arg Ile His 
225                 230                 235                 240 


Ser Leu Thr His Leu Asp Ser Val Thr Lys Ile His Asn Gly Ser Val 
                245                 250                 255     


Phe Thr Lys Asn Leu Cys Ser Gln Met Ser Ala Val Ser Gly Pro Leu 
            260                 265                 270         


Leu Gln Trp Leu Glu Asp Arg Leu Glu Gln Asn Gln Gln His Leu Gln 
        275                 280                 285             


Glu Leu Gln Gln Glu Lys Glu Glu Leu Met Gln Glu Leu Ser Ser Leu 
    290                 295                 300                 


Glu 
305 


<210> 221
<211> 492
<212> PRT
<213> Homo sapiens

<400> 221
Met Glu Pro Ser Ser Lys Lys Leu Thr Gly Arg Leu Met Leu Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Leu Gly Ser Leu Gln Phe Gly Tyr Asn Thr Gly Val 
            20                  25                  30          


Ile Asn Ala Pro Gln Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp 
        35                  40                  45              


Val His Arg Tyr Gly Glu Ser Ile Leu Pro Thr Thr Leu Thr Thr Leu 
    50                  55                  60                  


Trp Ser Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser 
65                  70                  75                  80  


Phe Ser Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met 
                85                  90                  95      


Leu Met Met Asn Leu Leu Ala Phe Val Ser Ala Val Leu Met Gly Phe 
            100                 105                 110         


Ser Lys Leu Gly Lys Ser Phe Glu Met Leu Ile Leu Gly Arg Phe Ile 
        115                 120                 125             


Ile Gly Val Tyr Cys Gly Leu Thr Thr Gly Phe Val Pro Met Tyr Val 
    130                 135                 140                 


Gly Glu Val Ser Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Leu His 
145                 150                 155                 160 


Gln Leu Gly Ile Val Val Gly Ile Leu Ile Ala Gln Val Phe Gly Leu 
                165                 170                 175     


Asp Ser Ile Met Gly Asn Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro 
        195                 200                 205             


Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala 
    210                 215                 220                 


Lys Ser Val Leu Lys Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp 
225                 230                 235                 240 


Leu Gln Glu Met Lys Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys 
                245                 250                 255     


Val Thr Ile Leu Glu Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro Ile 
            260                 265                 270         


Leu Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
        275                 280                 285             


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Lys Ala Gly Val Gln 
    290                 295                 300                 


Gln Pro Val Tyr Ala Thr Ile Gly Ser Gly Ile Val Asn Thr Ala Phe 
305                 310                 315                 320 


Thr Val Val Ser Leu Phe Val Val Glu Arg Ala Gly Arg Arg Thr Leu 
                325                 330                 335     


His Leu Ile Gly Leu Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr 
            340                 345                 350         


Ile Ala Leu Ala Leu Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser 
        355                 360                 365             


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly 
    370                 375                 380                 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Ala Ile Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
                405                 410                 415     


Ile Val Gly Met Cys Phe Gln Tyr Val Glu Gln Leu Cys Gly Pro Tyr 
            420                 425                 430         


Val Phe Ile Ile Phe Thr Val Leu Leu Val Leu Phe Phe Ile Phe Thr 
        435                 440                 445             


Tyr Phe Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala 
    450                 455                 460                 


Ser Gly Phe Arg Gln Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Phe His Pro Leu Gly Ala Asp Ser Gln Val 
                485                 490         


<210> 222
<211> 340
<212> PRT
<213> Homo sapiens

<400> 222
Met Ala Ala Ser Ser Ser Glu Ile Ser Glu Met Lys Gly Val Glu Glu 
1               5                   10                  15      


Ser Pro Lys Val Pro Gly Glu Gly Pro Gly His Ser Glu Ala Glu Thr 
            20                  25                  30          


Gly Pro Pro Gln Val Leu Ala Gly Val Pro Asp Gln Pro Glu Ala Pro 
        35                  40                  45              


Gln Pro Gly Pro Asn Thr Thr Ala Ala Pro Val Asp Ser Gly Pro Lys 
    50                  55                  60                  


Ala Gly Leu Ala Pro Glu Thr Thr Glu Thr Pro Ala Gly Ala Ser Glu 
65                  70                  75                  80  


Thr Ala Gln Ala Thr Asp Leu Ser Leu Ser Pro Gly Gly Glu Ser Lys 
                85                  90                  95      


Ala Asn Cys Ser Pro Glu Asp Pro Cys Gln Glu Thr Val Ser Lys Pro 
            100                 105                 110         


Glu Val Ser Lys Glu Ala Thr Ala Asp Gln Gly Ser Arg Leu Glu Ser 
        115                 120                 125             


Ala Ala Pro Pro Glu Pro Ala Pro Glu Pro Ala Pro Gln Pro Asp Pro 
    130                 135                 140                 


Arg Pro Asp Ser Gln Pro Thr Pro Lys Pro Ala Leu Gln Pro Glu Leu 
145                 150                 155                 160 


Pro Thr Gln Glu Asp Pro Thr Pro Glu Ile Leu Ser Glu Ser Val Gly 
                165                 170                 175     


Glu Lys Gln Glu Asn Gly Ala Val Val Pro Leu Gln Ala Gly Asp Gly 
            180                 185                 190         


Glu Glu Gly Pro Ala Pro Glu Pro His Ser Pro Pro Ser Lys Lys Ser 
        195                 200                 205             


Pro Pro Ala Asn Gly Ala Pro Pro Arg Val Leu Gln Gln Leu Val Glu 
    210                 215                 220                 


Glu Asp Arg Met Arg Arg Ala His Ser Gly His Pro Gly Ser Pro Arg 
225                 230                 235                 240 


Gly Ser Leu Ser Arg His Pro Ser Ser Gln Leu Ala Gly Pro Gly Val 
                245                 250                 255     


Glu Gly Gly Glu Gly Thr Gln Lys Pro Arg Asp Tyr Ile Ile Leu Ala 
            260                 265                 270         


Ile Leu Ser Cys Phe Cys Pro Met Trp Pro Val Asn Ile Val Ala Phe 
        275                 280                 285             


Ala Tyr Ala Val Met Ser Arg Asn Ser Leu Gln Gln Gly Asp Val Asp 
    290                 295                 300                 


Gly Ala Gln Arg Leu Gly Arg Val Ala Lys Leu Leu Ser Ile Val Ala 
305                 310                 315                 320 


Leu Val Gly Gly Val Leu Ile Ile Ile Ala Ser Cys Val Ile Asn Leu 
                325                 330                 335     


Gly Val Tyr Lys 
            340 


<210> 223
<211> 5202
<212> PRT
<213> Homo sapiens

<400> 223
Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      


Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          


Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              


Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  


Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  


Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      


Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         


Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             


Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 


Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 


Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     


Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         


Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             


Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 


Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 


Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     


Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         


Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             


Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 


Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 


Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     


Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         


Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             


Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 


Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 


Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     


Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         


Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             


Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 


Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 


Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     


Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         


Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             


Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 


Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 


Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     


Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         


Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             


Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 


Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 


Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     


Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         


Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             


Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 


Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 


Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     


Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         


Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             


Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 


Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 


Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     


Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         


Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             


Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 


Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 


Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     


Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         


Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             


Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 


Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 


His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     


Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         


Asp Pro Gln Thr Gly Arg Cys Gln  Pro Cys Asn Cys His  Leu Ser Gly 
        995                 1000                 1005             


Ala Leu  Asn Glu Thr Cys His  Leu Val Thr Gly Gln  Cys Phe Cys 
    1010                 1015                 1020             


Lys Gln  Phe Val Thr Gly Ser  Lys Cys Asp Ala Cys  Val Pro Ser 
    1025                 1030                 1035             


Ala Ser  His Leu Asp Val Asn  Asn Leu Leu Gly Cys  Ser Lys Thr 
    1040                 1045                 1050             


Pro Phe  Gln Gln Pro Pro Pro  Arg Gly Gln Val Gln  Ser Ser Ser 
    1055                 1060                 1065             


Ala Ile  Asn Leu Ser Trp Ser  Pro Pro Asp Ser Pro  Asn Ala His 
    1070                 1075                 1080             


Trp Leu  Thr Tyr Ser Leu Leu  Arg Asp Gly Phe Glu  Ile Tyr Thr 
    1085                 1090                 1095             


Thr Glu  Asp Gln Tyr Pro Tyr  Ser Ile Gln Tyr Phe  Leu Asp Thr 
    1100                 1105                 1110             


Asp Leu  Leu Pro Tyr Thr Lys  Tyr Ser Tyr Tyr Ile  Glu Thr Thr 
    1115                 1120                 1125             


Asn Val  His Gly Ser Thr Arg  Ser Val Ala Val Thr  Tyr Lys Thr 
    1130                 1135                 1140             


Lys Pro  Gly Val Pro Glu Gly  Asn Leu Thr Leu Ser  Tyr Ile Ile 
    1145                 1150                 1155             


Pro Ile  Gly Ser Asp Ser Val  Thr Leu Thr Trp Thr  Thr Leu Ser 
    1160                 1165                 1170             


Asn Gln  Ser Gly Pro Ile Glu  Lys Tyr Ile Leu Ser  Cys Ala Pro 
    1175                 1180                 1185             


Leu Ala  Gly Gly Gln Pro Cys  Val Ser Tyr Glu Gly  His Glu Thr 
    1190                 1195                 1200             


Ser Ala  Thr Ile Trp Asn Leu  Val Pro Phe Ala Lys  Tyr Asp Phe 
    1205                 1210                 1215             


Ser Val  Gln Ala Cys Thr Ser  Gly Gly Cys Leu His  Ser Leu Pro 
    1220                 1225                 1230             


Ile Thr  Val Thr Thr Ala Gln  Ala Pro Pro Gln Arg  Leu Ser Pro 
    1235                 1240                 1245             


Pro Lys  Met Gln Lys Ile Ser  Ser Thr Glu Leu His  Val Glu Trp 
    1250                 1255                 1260             


Ser Pro  Pro Ala Glu Leu Asn  Gly Ile Ile Ile Arg  Tyr Glu Leu 
    1265                 1270                 1275             


Tyr Met  Arg Arg Leu Arg Ser  Thr Lys Glu Thr Thr  Ser Glu Glu 
    1280                 1285                 1290             


Ser Arg  Val Phe Gln Ser Ser  Gly Trp Leu Ser Pro  His Ser Phe 
    1295                 1300                 1305             


Val Glu  Ser Ala Asn Glu Asn  Ala Leu Lys Pro Pro  Gln Thr Met 
    1310                 1315                 1320             


Thr Thr  Ile Thr Gly Leu Glu  Pro Tyr Thr Lys Tyr  Glu Phe Arg 
    1325                 1330                 1335             


Val Leu  Ala Val Asn Met Ala  Gly Ser Val Ser Ser  Ala Trp Val 
    1340                 1345                 1350             


Ser Glu  Arg Thr Gly Glu Ser  Ala Pro Val Phe Met  Ile Pro Pro 
    1355                 1360                 1365             


Ser Val  Phe Pro Leu Ser Ser  Tyr Ser Leu Asn Ile  Ser Trp Glu 
    1370                 1375                 1380             


Lys Pro  Ala Asp Asn Val Thr  Arg Gly Lys Val Val  Gly Tyr Asp 
    1385                 1390                 1395             


Ile Asn  Met Leu Ser Glu Gln  Ser Pro Gln Gln Ser  Ile Pro Met 
    1400                 1405                 1410             


Ala Phe  Ser Gln Leu Leu His  Thr Ala Lys Ser Gln  Glu Leu Ser 
    1415                 1420                 1425             


Tyr Thr  Val Glu Gly Leu Lys  Pro Tyr Arg Ile Tyr  Glu Phe Thr 
    1430                 1435                 1440             


Ile Thr  Leu Cys Asn Ser Val  Gly Cys Val Thr Ser  Ala Ser Gly 
    1445                 1450                 1455             


Ala Gly  Gln Thr Leu Ala Ala  Ala Pro Ala Gln Leu  Arg Pro Pro 
    1460                 1465                 1470             


Leu Val  Lys Gly Ile Asn Ser  Thr Thr Ile His Leu  Arg Trp Phe 
    1475                 1480                 1485             


Pro Pro  Glu Glu Leu Asn Gly  Pro Ser Pro Ile Tyr  Gln Leu Glu 
    1490                 1495                 1500             


Arg Arg  Glu Ser Ser Leu Pro  Ala Leu Met Thr Thr  Met Met Lys 
    1505                 1510                 1515             


Gly Ile  Arg Phe Ile Gly Asn  Gly Tyr Cys Lys Phe  Pro Ser Ser 
    1520                 1525                 1530             


Thr His  Pro Val Asn Thr Asp  Phe Thr Gly Ile Lys  Ala Ser Phe 
    1535                 1540                 1545             


Arg Thr  Lys Val Pro Glu Gly  Leu Ile Val Phe Ala  Ala Ser Pro 
    1550                 1555                 1560             


Gly Asn  Gln Glu Glu Tyr Phe  Ala Leu Gln Leu Lys  Lys Gly Arg 
    1565                 1570                 1575             


Leu Tyr  Phe Leu Phe Asp Pro  Gln Gly Ser Pro Val  Glu Val Thr 
    1580                 1585                 1590             


Thr Thr  Asn Asp His Gly Lys  Gln Tyr Ser Asp Gly  Lys Trp His 
    1595                 1600                 1605             


Glu Ile  Ile Ala Ile Arg His  Gln Ala Phe Gly Gln  Ile Thr Leu 
    1610                 1615                 1620             


Asp Gly  Ile Tyr Thr Gly Ser  Ser Ala Ile Leu Asn  Gly Ser Thr 
    1625                 1630                 1635             


Val Ile  Gly Asp Asn Thr Gly  Val Phe Leu Gly Gly  Leu Pro Arg 
    1640                 1645                 1650             


Ser Tyr  Thr Ile Leu Arg Lys  Asp Pro Glu Ile Ile  Gln Lys Gly 
    1655                 1660                 1665             


Phe Val  Gly Cys Leu Lys Asp  Val His Phe Met Lys  Asn Tyr Asn 
    1670                 1675                 1680             


Pro Ser  Ala Ile Trp Glu Pro  Leu Asp Trp Gln Ser  Ser Glu Glu 
    1685                 1690                 1695             


Gln Ile  Asn Val Tyr Asn Ser  Trp Glu Gly Cys Pro  Ala Ser Leu 
    1700                 1705                 1710             


Asn Glu  Gly Ala Gln Phe Leu  Gly Ala Gly Phe Leu  Glu Leu His 
    1715                 1720                 1725             


Pro Tyr  Met Phe His Gly Gly  Met Asn Phe Glu Ile  Ser Phe Lys 
    1730                 1735                 1740             


Phe Arg  Thr Asp Gln Leu Asn  Gly Leu Leu Leu Phe  Val Tyr Asn 
    1745                 1750                 1755             


Lys Asp  Gly Pro Asp Phe Leu  Ala Met Glu Leu Lys  Ser Gly Ile 
    1760                 1765                 1770             


Leu Thr  Phe Arg Leu Asn Thr  Ser Leu Ala Phe Thr  Gln Val Asp 
    1775                 1780                 1785             


Leu Leu  Leu Gly Leu Ser Tyr  Cys Asn Gly Lys Trp  Asn Lys Val 
    1790                 1795                 1800             


Ile Ile  Lys Lys Glu Gly Ser  Phe Ile Ser Ala Ser  Val Asn Gly 
    1805                 1810                 1815             


Leu Met  Lys His Ala Ser Glu  Ser Gly Asp Gln Pro  Leu Val Val 
    1820                 1825                 1830             


Asn Ser  Pro Val Tyr Val Gly  Gly Ile Pro Gln Glu  Leu Leu Asn 
    1835                 1840                 1845             


Ser Tyr  Gln His Leu Cys Leu  Glu Gln Gly Phe Gly  Gly Cys Met 
    1850                 1855                 1860             


Lys Asp  Val Lys Phe Thr Arg  Gly Ala Val Val Asn  Leu Ala Ser 
    1865                 1870                 1875             


Val Ser  Ser Gly Ala Val Arg  Val Asn Leu Asp Gly  Cys Leu Ser 
    1880                 1885                 1890             


Thr Asp  Ser Ala Val Asn Cys  Arg Gly Asn Asp Ser  Ile Leu Val 
    1895                 1900                 1905             


Tyr Gln  Gly Lys Glu Gln Ser  Val Tyr Glu Gly Gly  Leu Gln Pro 
    1910                 1915                 1920             


Phe Thr  Glu Tyr Leu Tyr Arg  Val Ile Ala Ser His  Glu Gly Gly 
    1925                 1930                 1935             


Ser Val  Tyr Ser Asp Trp Ser  Arg Gly Arg Thr Thr  Gly Ala Ala 
    1940                 1945                 1950             


Pro Gln  Ser Val Pro Thr Pro  Ser Arg Val Arg Ser  Leu Asn Gly 
    1955                 1960                 1965             


Tyr Ser  Ile Glu Val Thr Trp  Asp Glu Pro Val Val  Arg Gly Val 
    1970                 1975                 1980             


Ile Glu  Lys Tyr Ile Leu Lys  Ala Tyr Ser Glu Asp  Ser Thr Arg 
    1985                 1990                 1995             


Pro Pro  Arg Met Pro Ser Ala  Ser Ala Glu Phe Val  Asn Thr Ser 
    2000                 2005                 2010             


Asn Leu  Thr Gly Ile Leu Thr  Gly Leu Leu Pro Phe  Lys Asn Tyr 
    2015                 2020                 2025             


Ala Val  Thr Leu Thr Ala Cys  Thr Leu Ala Gly Cys  Thr Glu Ser 
    2030                 2035                 2040             


Ser His  Ala Leu Asn Ile Ser  Thr Pro Gln Glu Ala  Pro Gln Glu 
    2045                 2050                 2055             


Val Gln  Pro Pro Val Ala Lys  Ser Leu Pro Ser Ser  Leu Leu Leu 
    2060                 2065                 2070             


Ser Trp  Asn Pro Pro Lys Lys  Ala Asn Gly Ile Ile  Thr Gln Tyr 
    2075                 2080                 2085             


Cys Leu  Tyr Met Asp Gly Arg  Leu Ile Tyr Ser Gly  Ser Glu Glu 
    2090                 2095                 2100             


Asn Tyr  Ile Val Thr Asp Leu  Ala Val Phe Thr Pro  His Gln Phe 
    2105                 2110                 2115             


Leu Leu  Ser Ala Cys Thr His  Val Gly Cys Thr Asn  Ser Ser Trp 
    2120                 2125                 2130             


Val Leu  Leu Tyr Thr Ala Gln  Leu Pro Pro Glu His  Val Asp Ser 
    2135                 2140                 2145             


Pro Val  Leu Thr Val Leu Asp  Ser Arg Thr Ile His  Ile Gln Trp 
    2150                 2155                 2160             


Lys Gln  Pro Arg Lys Ile Ser  Gly Ile Leu Glu Arg  Tyr Val Leu 
    2165                 2170                 2175             


Tyr Met  Ser Asn His Thr His  Asp Phe Thr Ile Trp  Ser Val Ile 
    2180                 2185                 2190             


Tyr Asn  Ser Thr Glu Leu Phe  Gln Asp His Met Leu  Gln Tyr Val 
    2195                 2200                 2205             


Leu Pro  Gly Asn Lys Tyr Leu  Ile Lys Leu Gly Ala  Cys Thr Gly 
    2210                 2215                 2220             


Gly Gly  Cys Thr Val Ser Glu  Ala Ser Glu Ala Leu  Thr Asp Glu 
    2225                 2230                 2235             


Asp Ile  Pro Glu Gly Val Pro  Ala Pro Lys Ala His  Ser Tyr Ser 
    2240                 2245                 2250             


Pro Asp  Ser Phe Asn Val Ser  Trp Thr Glu Pro Glu  Tyr Pro Asn 
    2255                 2260                 2265             


Gly Val  Ile Thr Ser Tyr Gly  Leu Tyr Leu Asp Gly  Ile Leu Ile 
    2270                 2275                 2280             


His Asn  Ser Ser Glu Leu Ser  Tyr Arg Ala Tyr Gly  Phe Ala Pro 
    2285                 2290                 2295             


Trp Ser  Leu His Ser Phe Arg  Val Gln Ala Cys Thr  Ala Lys Gly 
    2300                 2305                 2310             


Cys Ala  Leu Gly Pro Leu Val  Glu Asn Arg Thr Leu  Glu Ala Pro 
    2315                 2320                 2325             


Pro Glu  Gly Thr Val Asn Val  Phe Val Lys Thr Gln  Gly Ser Arg 
    2330                 2335                 2340             


Lys Ala  His Val Arg Trp Glu  Ala Pro Phe Arg Pro  Asn Gly Leu 
    2345                 2350                 2355             


Leu Thr  His Ser Val Leu Phe  Thr Gly Ile Phe Tyr  Val Asp Pro 
    2360                 2365                 2370             


Val Gly  Asn Asn Tyr Thr Leu  Leu Asn Val Thr Lys  Val Met Tyr 
    2375                 2380                 2385             


Ser Gly  Glu Glu Thr Asn Leu  Trp Val Leu Ile Asp  Gly Leu Val 
    2390                 2395                 2400             


Pro Phe  Thr Asn Tyr Thr Val  Gln Val Asn Ile Ser  Asn Ser Gln 
    2405                 2410                 2415             


Gly Ser  Leu Ile Thr Asp Pro  Ile Thr Ile Ala Met  Pro Pro Gly 
    2420                 2425                 2430             


Ala Pro  Asp Gly Val Leu Pro  Pro Arg Leu Ser Ser  Ala Thr Pro 
    2435                 2440                 2445             


Thr Ser  Leu Gln Val Val Trp  Ser Thr Pro Ala Arg  Asn Asn Ala 
    2450                 2455                 2460             


Pro Gly  Ser Pro Arg Tyr Gln  Leu Gln Met Arg Ser  Gly Asp Ser 
    2465                 2470                 2475             


Thr His  Gly Phe Leu Glu Leu  Phe Ser Asn Pro Ser  Ala Ser Leu 
    2480                 2485                 2490             


Ser Tyr  Glu Val Ser Asp Leu  Gln Pro Tyr Thr Glu  Tyr Met Phe 
    2495                 2500                 2505             


Arg Leu  Val Ala Ser Asn Gly  Phe Gly Ser Ala His  Ser Ser Trp 
    2510                 2515                 2520             


Ile Pro  Phe Met Thr Ala Glu  Asp Lys Pro Gly Pro  Val Val Pro 
    2525                 2530                 2535             


Pro Ile  Leu Leu Asp Val Lys  Ser Arg Met Met Leu  Val Thr Trp 
    2540                 2545                 2550             


Gln His  Pro Arg Lys Ser Asn  Gly Val Ile Thr His  Tyr Asn Ile 
    2555                 2560                 2565             


Tyr Leu  His Gly Arg Leu Tyr  Leu Arg Thr Pro Gly  Asn Val Thr 
    2570                 2575                 2580             


Asn Cys  Thr Val Met His Leu  His Pro Tyr Thr Ala  Tyr Lys Phe 
    2585                 2590                 2595             


Gln Val  Glu Ala Cys Thr Ser  Lys Gly Cys Ser Leu  Ser Pro Glu 
    2600                 2605                 2610             


Ser Gln  Thr Val Trp Thr Leu  Pro Gly Ala Pro Glu  Gly Ile Pro 
    2615                 2620                 2625             


Ser Pro  Glu Leu Phe Ser Asp  Thr Pro Thr Ser Val  Ile Ile Ser 
    2630                 2635                 2640             


Trp Gln  Pro Pro Thr His Pro  Asn Gly Leu Val Glu  Asn Phe Thr 
    2645                 2650                 2655             


Ile Glu  Arg Arg Val Lys Gly  Lys Glu Glu Val Thr  Thr Leu Val 
    2660                 2665                 2670             


Thr Leu  Pro Arg Ser His Ser  Met Arg Phe Ile Asp  Lys Thr Ser 
    2675                 2680                 2685             


Ala Leu  Ser Pro Trp Thr Lys  Tyr Glu Tyr Arg Val  Leu Met Ser 
    2690                 2695                 2700             


Thr Leu  His Gly Gly Thr Asn  Ser Ser Ala Trp Val  Glu Val Thr 
    2705                 2710                 2715             


Thr Arg  Pro Ser Arg Pro Ala  Gly Val Gln Pro Pro  Val Val Thr 
    2720                 2725                 2730             


Val Leu  Glu Pro Asp Ala Val  Gln Val Thr Trp Lys  Pro Pro Leu 
    2735                 2740                 2745             


Ile Gln  Asn Gly Asp Ile Leu  Ser Tyr Glu Ile His  Met Pro Asp 
    2750                 2755                 2760             


Pro His  Ile Thr Leu Thr Asn  Val Thr Ser Ala Val  Leu Ser Gln 
    2765                 2770                 2775             


Lys Val  Thr His Leu Ile Pro  Phe Thr Asn Tyr Ser  Val Thr Ile 
    2780                 2785                 2790             


Val Ala  Cys Ser Gly Gly Asn  Gly Tyr Leu Gly Gly  Cys Thr Glu 
    2795                 2800                 2805             


Ser Leu  Pro Thr Tyr Val Thr  Thr His Pro Thr Val  Pro Gln Asn 
    2810                 2815                 2820             


Val Gly  Pro Leu Ser Val Ile  Pro Leu Ser Glu Ser  Tyr Val Val 
    2825                 2830                 2835             


Ile Ser  Trp Gln Pro Pro Ser  Lys Pro Asn Gly Pro  Asn Leu Arg 
    2840                 2845                 2850             


Tyr Glu  Leu Leu Arg Arg Lys  Ile Gln Gln Pro Leu  Ala Ser Asn 
    2855                 2860                 2865             


Pro Pro  Glu Asp Leu Asn Arg  Trp His Asn Ile Tyr  Ser Gly Thr 
    2870                 2875                 2880             


Gln Trp  Leu Tyr Glu Asp Lys  Gly Leu Ser Arg Phe  Thr Thr Tyr 
    2885                 2890                 2895             


Glu Tyr  Met Leu Phe Val His  Asn Ser Val Gly Phe  Thr Pro Ser 
    2900                 2905                 2910             


Arg Glu  Val Thr Val Thr Thr  Leu Ala Gly Leu Pro  Glu Arg Gly 
    2915                 2920                 2925             


Ala Asn  Leu Thr Ala Ser Val  Leu Asn His Thr Ala  Ile Asp Val 
    2930                 2935                 2940             


Arg Trp  Ala Lys Pro Thr Val  Gln Asp Leu Gln Gly  Glu Val Glu 
    2945                 2950                 2955             


Tyr Tyr  Thr Leu Phe Trp Ser  Ser Ala Thr Ser Asn  Asp Ser Leu 
    2960                 2965                 2970             


Lys Ile  Leu Pro Asp Val Asn  Ser His Val Ile Gly  His Leu Lys 
    2975                 2980                 2985             


Pro Asn  Thr Glu Tyr Trp Ile  Phe Ile Ser Val Phe  Asn Gly Val 
    2990                 2995                 3000             


His Ser  Ile Asn Ser Ala Gly  Leu His Ala Thr Thr  Cys Asp Gly 
    3005                 3010                 3015             


Glu Pro  Gln Gly Met Leu Pro  Pro Glu Val Val Ile  Ile Asn Ser 
    3020                 3025                 3030             


Thr Ala  Val Arg Val Ile Trp  Thr Ser Pro Ser Asn  Pro Asn Gly 
    3035                 3040                 3045             


Val Val  Thr Glu Tyr Ser Ile  Tyr Val Asn Asn Lys  Leu Tyr Lys 
    3050                 3055                 3060             


Thr Gly  Met Asn Val Pro Gly  Ser Phe Ile Leu Arg  Asp Leu Ser 
    3065                 3070                 3075             


Pro Phe  Thr Ile Tyr Asp Ile  Gln Val Glu Val Cys  Thr Ile Tyr 
    3080                 3085                 3090             


Ala Cys  Val Lys Ser Asn Gly  Thr Gln Ile Thr Thr  Val Glu Asp 
    3095                 3100                 3105             


Thr Pro  Ser Asp Ile Pro Thr  Pro Thr Ile Arg Gly  Ile Thr Ser 
    3110                 3115                 3120             


Arg Ser  Leu Gln Ile Asp Trp  Val Ser Pro Arg Lys  Pro Asn Gly 
    3125                 3130                 3135             


Ile Ile  Leu Gly Tyr Asp Leu  Leu Trp Lys Thr Trp  Tyr Pro Cys 
    3140                 3145                 3150             


Ala Lys  Thr Gln Lys Leu Val  Gln Asp Gln Ser Asp  Glu Leu Cys 
    3155                 3160                 3165             


Lys Ala  Val Arg Cys Gln Lys  Pro Glu Ser Ile Cys  Gly His Ile 
    3170                 3175                 3180             


Cys Tyr  Ser Ser Glu Ala Lys  Val Cys Cys Asn Gly  Val Leu Tyr 
    3185                 3190                 3195             


Asn Pro  Lys Pro Gly His Arg  Cys Cys Glu Glu Lys  Tyr Ile Pro 
    3200                 3205                 3210             


Phe Val  Leu Asn Ser Thr Gly  Val Cys Cys Gly Gly  Arg Ile Gln 
    3215                 3220                 3225             


Glu Ala  Gln Pro Asn His Gln  Cys Cys Ser Gly Tyr  Tyr Ala Arg 
    3230                 3235                 3240             


Ile Leu  Pro Gly Glu Val Cys  Cys Pro Asp Glu Gln  His Asn Arg 
    3245                 3250                 3255             


Val Ser  Val Gly Ile Gly Asp  Ser Cys Cys Gly Arg  Met Pro Tyr 
    3260                 3265                 3270             


Ser Thr  Ser Gly Asn Gln Ile  Cys Cys Ala Gly Arg  Leu His Asp 
    3275                 3280                 3285             


Gly His  Gly Gln Lys Cys Cys  Gly Arg Gln Ile Val  Ser Asn Asp 
    3290                 3295                 3300             


Leu Glu  Cys Cys Gly Gly Glu  Glu Gly Val Val Tyr  Asn Arg Leu 
    3305                 3310                 3315             


Pro Gly  Met Phe Cys Cys Gly  Gln Asp Tyr Val Asn  Met Ser Asp 
    3320                 3325                 3330             


Thr Ile  Cys Cys Ser Ala Ser  Ser Gly Glu Ser Lys  Ala His Ile 
    3335                 3340                 3345             


Lys Lys  Asn Asp Pro Val Pro  Val Lys Cys Cys Glu  Thr Glu Leu 
    3350                 3355                 3360             


Ile Pro  Lys Ser Gln Lys Cys  Cys Asn Gly Val Gly  Tyr Asn Pro 
    3365                 3370                 3375             


Leu Lys  Tyr Val Cys Ser Asp  Lys Ile Ser Thr Gly  Met Met Met 
    3380                 3385                 3390             


Lys Glu  Thr Lys Glu Cys Arg  Ile Leu Cys Pro Ala  Ser Met Glu 
    3395                 3400                 3405             


Ala Thr  Glu His Cys Gly Arg  Cys Asp Phe Asn Phe  Thr Ser His 
    3410                 3415                 3420             


Ile Cys  Thr Val Ile Arg Gly  Ser His Asn Ser Thr  Gly Lys Ala 
    3425                 3430                 3435             


Ser Ile  Glu Glu Met Cys Ser  Ser Ala Glu Glu Thr  Ile His Thr 
    3440                 3445                 3450             


Gly Ser  Val Asn Thr Tyr Ser  Tyr Thr Asp Val Asn  Leu Lys Pro 
    3455                 3460                 3465             


Tyr Met  Thr Tyr Glu Tyr Arg  Ile Ser Ala Trp Asn  Ser Tyr Gly 
    3470                 3475                 3480             


Arg Gly  Leu Ser Lys Ala Val  Arg Ala Arg Thr Lys  Glu Asp Val 
    3485                 3490                 3495             


Pro Gln  Gly Val Ser Pro Pro  Thr Trp Thr Lys Ile  Asp Asn Leu 
    3500                 3505                 3510             


Glu Asp  Thr Ile Val Leu Asn  Trp Arg Lys Pro Ile  Gln Ser Asn 
    3515                 3520                 3525             


Gly Pro  Ile Ile Tyr Tyr Ile  Leu Leu Arg Asn Gly  Ile Glu Arg 
    3530                 3535                 3540             


Phe Arg  Gly Thr Ser Leu Ser  Phe Ser Asp Lys Glu  Gly Ile Gln 
    3545                 3550                 3555             


Pro Phe  Gln Glu Tyr Ser Tyr  Gln Leu Lys Ala Cys  Thr Val Ala 
    3560                 3565                 3570             


Gly Cys  Ala Thr Ser Ser Lys  Val Val Ala Ala Thr  Thr Gln Gly 
    3575                 3580                 3585             


Val Pro  Glu Ser Ile Leu Pro  Pro Ser Ile Thr Ala  Leu Ser Ala 
    3590                 3595                 3600             


Val Ala  Leu His Leu Ser Trp  Ser Val Pro Glu Lys  Ser Asn Gly 
    3605                 3610                 3615             


Val Ile  Lys Glu Tyr Gln Ile  Arg Gln Val Gly Lys  Gly Leu Ile 
    3620                 3625                 3630             


His Thr  Asp Thr Thr Asp Arg  Arg Gln His Thr Val  Thr Gly Leu 
    3635                 3640                 3645             


Gln Pro  Tyr Thr Asn Tyr Ser  Phe Thr Leu Thr Ala  Cys Thr Ser 
    3650                 3655                 3660             


Ala Gly  Cys Thr Ser Ser Glu  Pro Phe Leu Gly Gln  Thr Leu Gln 
    3665                 3670                 3675             


Ala Ala  Pro Glu Gly Val Trp  Val Thr Pro Arg His  Ile Ile Ile 
    3680                 3685                 3690             


Asn Ser  Thr Thr Val Glu Leu  Tyr Trp Ser Leu Pro  Glu Lys Pro 
    3695                 3700                 3705             


Asn Gly  Leu Val Ser Gln Tyr  Gln Leu Ser Arg Asn  Gly Asn Leu 
    3710                 3715                 3720             


Leu Phe  Leu Gly Gly Ser Glu  Glu Gln Asn Phe Thr  Asp Lys Asn 
    3725                 3730                 3735             


Leu Glu  Pro Asn Ser Arg Tyr  Thr Tyr Lys Leu Glu  Val Lys Thr 
    3740                 3745                 3750             


Gly Gly  Gly Ser Ser Ala Ser  Asp Asp Tyr Ile Val  Gln Thr Pro 
    3755                 3760                 3765             


Met Ser  Thr Pro Glu Glu Ile  Tyr Pro Pro Tyr Asn  Ile Thr Val 
    3770                 3775                 3780             


Ile Gly  Pro Tyr Ser Ile Phe  Val Ala Trp Ile Pro  Pro Gly Ile 
    3785                 3790                 3795             


Leu Ile  Pro Glu Ile Pro Val  Glu Tyr Asn Val Leu  Leu Asn Asp 
    3800                 3805                 3810             


Gly Ser  Val Thr Pro Leu Ala  Phe Ser Val Gly His  His Gln Ser 
    3815                 3820                 3825             


Thr Leu  Leu Glu Asn Leu Thr  Pro Phe Thr Gln Tyr  Glu Ile Arg 
    3830                 3835                 3840             


Ile Gln  Ala Cys Gln Asn Gly  Ser Cys Gly Val Ser  Ser Arg Met 
    3845                 3850                 3855             


Phe Val  Lys Thr Pro Glu Ala  Ala Pro Met Asp Leu  Asn Ser Pro 
    3860                 3865                 3870             


Val Leu  Lys Ala Leu Gly Ser  Ala Cys Ile Glu Ile  Lys Trp Met 
    3875                 3880                 3885             


Pro Pro  Glu Lys Pro Asn Gly  Ile Ile Ile Asn Tyr  Phe Ile Tyr 
    3890                 3895                 3900             


Arg Arg  Pro Ala Gly Ile Glu  Glu Glu Ser Val Leu  Phe Val Trp 
    3905                 3910                 3915             


Ser Glu  Gly Ala Leu Glu Phe  Met Asp Glu Gly Asp  Thr Leu Arg 
    3920                 3925                 3930             


Pro Phe  Thr Leu Tyr Glu Tyr  Arg Val Arg Ala Cys  Asn Ser Lys 
    3935                 3940                 3945             


Gly Ser  Val Glu Ser Leu Trp  Ser Leu Thr Gln Thr  Leu Glu Ala 
    3950                 3955                 3960             


Pro Pro  Gln Asp Phe Pro Ala  Pro Trp Ala Gln Ala  Thr Ser Ala 
    3965                 3970                 3975             


His Ser  Val Leu Leu Asn Trp  Thr Lys Pro Glu Ser  Pro Asn Gly 
    3980                 3985                 3990             


Ile Ile  Ser His Tyr Arg Val  Val Tyr Gln Glu Arg  Pro Asp Asp 
    3995                 4000                 4005             


Pro Thr  Phe Asn Ser Pro Thr  Val His Ala Phe Thr  Val Lys Gly 
    4010                 4015                 4020             


Thr Ser  His Gln Ala His Leu  Tyr Gly Leu Glu Pro  Phe Thr Thr 
    4025                 4030                 4035             


Tyr Arg  Ile Gly Val Val Ala  Ala Asn His Ala Gly  Glu Ile Leu 
    4040                 4045                 4050             


Ser Pro  Trp Thr Leu Ile Gln  Thr Leu Glu Ser Ser  Pro Ser Gly 
    4055                 4060                 4065             


Leu Arg  Asn Phe Ile Val Glu  Gln Lys Glu Asn Gly  Arg Ala Leu 
    4070                 4075                 4080             


Leu Leu  Gln Trp Ser Glu Pro  Met Arg Thr Asn Gly  Val Ile Lys 
    4085                 4090                 4095             


Thr Tyr  Asn Ile Phe Ser Asp  Gly Phe Leu Glu Tyr  Ser Gly Leu 
    4100                 4105                 4110             


Asn Arg  Gln Phe Leu Phe Arg  Arg Leu Asp Pro Phe  Thr Leu Tyr 
    4115                 4120                 4125             


Thr Leu  Thr Leu Glu Ala Cys  Thr Arg Ala Gly Cys  Ala His Ser 
    4130                 4135                 4140             


Ala Pro  Gln Pro Leu Trp Thr  Asp Glu Ala Pro Pro  Asp Ser Gln 
    4145                 4150                 4155             


Leu Ala  Pro Thr Val His Ser  Val Lys Ser Thr Ser  Val Glu Leu 
    4160                 4165                 4170             


Ser Trp  Ser Glu Pro Val Asn  Pro Asn Gly Lys Ile  Ile Arg Tyr 
    4175                 4180                 4185             


Glu Val  Ile Arg Arg Cys Phe  Glu Gly Lys Ala Trp  Gly Asn Gln 
    4190                 4195                 4200             


Thr Ile  Gln Ala Asp Glu Lys  Ile Val Phe Thr Glu  Tyr Asn Thr 
    4205                 4210                 4215             


Glu Arg  Asn Thr Phe Met Tyr  Asn Asp Thr Gly Leu  Gln Pro Trp 
    4220                 4225                 4230             


Thr Gln  Cys Glu Tyr Lys Ile  Tyr Thr Trp Asn Ser  Ala Gly His 
    4235                 4240                 4245             


Thr Cys  Ser Ser Trp Asn Val  Val Arg Thr Leu Gln  Ala Pro Pro 
    4250                 4255                 4260             


Glu Gly  Leu Ser Pro Pro Val  Ile Ser Tyr Val Ser  Met Asn Pro 
    4265                 4270                 4275             


Gln Lys  Leu Leu Ile Ser Trp  Ile Pro Pro Glu Gln  Ser Asn Gly 
    4280                 4285                 4290             


Ile Ile  Gln Ser Tyr Arg Leu  Gln Arg Asn Glu Met  Leu Tyr Pro 
    4295                 4300                 4305             


Phe Ser  Phe Asp Pro Val Thr  Phe Asn Tyr Thr Asp  Glu Glu Leu 
    4310                 4315                 4320             


Leu Pro  Phe Ser Thr Tyr Ser  Tyr Ala Leu Gln Ala  Cys Thr Ser 
    4325                 4330                 4335             


Gly Gly  Cys Ser Thr Ser Lys  Pro Thr Ser Ile Thr  Thr Leu Glu 
    4340                 4345                 4350             


Ala Ala  Pro Ser Glu Val Ser  Pro Pro Asp Leu Trp  Ala Val Ser 
    4355                 4360                 4365             


Ala Thr  Gln Met Asn Val Cys  Trp Ser Pro Pro Thr  Val Gln Asn 
    4370                 4375                 4380             


Gly Lys  Ile Thr Lys Tyr Leu  Val Arg Tyr Asp Asn  Lys Glu Ser 
    4385                 4390                 4395             


Leu Ala  Gly Gln Gly Leu Cys  Leu Leu Val Ser His  Leu Gln Pro 
    4400                 4405                 4410             


Tyr Ser  Gln Tyr Asn Phe Ser  Leu Val Ala Cys Thr  Asn Gly Gly 
    4415                 4420                 4425             


Cys Thr  Ala Ser Val Ser Lys  Ser Ala Trp Thr Met  Glu Ala Leu 
    4430                 4435                 4440             


Pro Glu  Asn Met Asp Ser Pro  Thr Leu Gln Val Thr  Gly Ser Glu 
    4445                 4450                 4455             


Ser Ile  Glu Ile Thr Trp Lys  Pro Pro Arg Asn Pro  Asn Gly Gln 
    4460                 4465                 4470             


Ile Arg  Ser Tyr Glu Leu Arg  Arg Asp Gly Thr Ile  Val Tyr Thr 
    4475                 4480                 4485             


Gly Leu  Glu Thr Arg Tyr Arg  Asp Phe Thr Leu Thr  Pro Gly Val 
    4490                 4495                 4500             


Glu Tyr  Ser Tyr Thr Val Thr  Ala Ser Asn Ser Gln  Gly Gly Ile 
    4505                 4510                 4515             


Leu Ser  Pro Leu Val Lys Asp  Arg Thr Ser Pro Ser  Ala Pro Ser 
    4520                 4525                 4530             


Gly Met  Glu Pro Pro Lys Leu  Gln Ala Arg Gly Pro  Gln Glu Ile 
    4535                 4540                 4545             


Leu Val  Asn Trp Asp Pro Pro  Val Arg Thr Asn Gly  Asp Ile Ile 
    4550                 4555                 4560             


Asn Tyr  Thr Leu Phe Ile Arg  Glu Leu Phe Glu Arg  Glu Thr Lys 
    4565                 4570                 4575             


Ile Ile  His Ile Asn Thr Thr  His Asn Ser Phe Gly  Met Gln Ser 
    4580                 4585                 4590             


Tyr Ile  Val Asn Gln Leu Lys  Pro Phe His Arg Tyr  Glu Ile Arg 
    4595                 4600                 4605             


Ile Gln  Ala Cys Thr Thr Leu  Gly Cys Ala Ser Ser  Asp Trp Thr 
    4610                 4615                 4620             


Phe Ile  Gln Thr Pro Glu Ile  Ala Pro Leu Met Gln  Pro Pro Pro 
    4625                 4630                 4635             


His Leu  Glu Val Gln Met Ala  Pro Gly Gly Phe Gln  Pro Thr Val 
    4640                 4645                 4650             


Ser Leu  Leu Trp Thr Gly Pro  Leu Gln Pro Asn Gly  Lys Val Leu 
    4655                 4660                 4665             


Tyr Tyr  Glu Leu Tyr Arg Arg  Gln Ile Ala Thr Gln  Pro Arg Lys 
    4670                 4675                 4680             


Ser Asn  Pro Val Leu Ile Tyr  Asn Gly Ser Ser Thr  Ser Phe Ile 
    4685                 4690                 4695             


Asp Ser  Glu Leu Leu Pro Phe  Thr Glu Tyr Glu Tyr  Gln Val Trp 
    4700                 4705                 4710             


Ala Val  Asn Ser Ala Gly Lys  Ala Pro Ser Ser Trp  Thr Trp Cys 
    4715                 4720                 4725             


Arg Thr  Gly Pro Ala Pro Pro  Glu Gly Leu Arg Ala  Pro Thr Phe 
    4730                 4735                 4740             


His Val  Ile Ser Ser Thr Gln  Ala Val Val Asn Ile  Ser Ala Pro 
    4745                 4750                 4755             


Gly Lys  Pro Asn Gly Ile Val  Ser Leu Tyr Arg Leu  Phe Ser Ser 
    4760                 4765                 4770             


Ser Ala  His Gly Ala Glu Thr  Val Leu Ser Glu Gly  Met Ala Thr 
    4775                 4780                 4785             


Gln Gln  Thr Leu His Gly Leu  Gln Ala Phe Thr Asn  Tyr Ser Ile 
    4790                 4795                 4800             


Gly Val  Glu Ala Cys Thr Cys  Phe Asn Cys Cys Ser  Lys Gly Pro 
    4805                 4810                 4815             


Thr Ala  Glu Leu Arg Thr His  Pro Ala Pro Pro Ser  Gly Leu Ser 
    4820                 4825                 4830             


Ser Pro  Gln Ile Gly Thr Leu  Ala Ser Arg Thr Ala  Ser Phe Arg 
    4835                 4840                 4845             


Trp Ser  Pro Pro Met Phe Pro  Asn Gly Val Ile His  Ser Tyr Glu 
    4850                 4855                 4860             


Leu Gln  Phe His Val Ala Cys  Pro Pro Asp Ser Ala  Leu Pro Cys 
    4865                 4870                 4875             


Thr Pro  Ser Gln Ile Glu Thr  Lys Tyr Thr Gly Leu  Gly Gln Lys 
    4880                 4885                 4890             


Ala Ser  Leu Gly Gly Leu Gln  Pro Tyr Thr Thr Tyr  Lys Leu Arg 
    4895                 4900                 4905             


Val Val  Ala His Asn Glu Val  Gly Ser Thr Ala Ser  Glu Trp Ile 
    4910                 4915                 4920             


Ser Phe  Thr Thr Gln Lys Glu  Leu Pro Gln Tyr Arg  Ala Pro Phe 
    4925                 4930                 4935             


Ser Val  Asp Ser Asn Leu Ser  Val Val Cys Val Asn  Trp Ser Asp 
    4940                 4945                 4950             


Thr Phe  Leu Leu Asn Gly Gln  Leu Lys Glu Tyr Val  Leu Thr Asp 
    4955                 4960                 4965             


Gly Gly  Arg Arg Val Tyr Ser  Gly Leu Asp Thr Thr  Leu Tyr Ile 
    4970                 4975                 4980             


Pro Arg  Thr Ala Asp Lys Thr  Phe Phe Phe Gln Val  Ile Cys Thr 
    4985                 4990                 4995             


Thr Asp  Glu Gly Ser Val Lys  Thr Pro Leu Ile Gln  Tyr Asp Thr 
    5000                 5005                 5010             


Ser Thr  Gly Leu Gly Leu Val  Leu Thr Thr Pro Gly  Lys Lys Lys 
    5015                 5020                 5025             


Gly Ser  Arg Ser Lys Ser Thr  Glu Phe Tyr Ser Glu  Leu Trp Phe 
    5030                 5035                 5040             


Ile Val  Leu Met Ala Met Leu  Gly Leu Ile Leu Leu  Ala Ile Phe 
    5045                 5050                 5055             


Leu Ser  Leu Ile Leu Gln Arg  Lys Ile His Lys Glu  Pro Tyr Ile 
    5060                 5065                 5070             


Arg Glu  Arg Pro Pro Leu Val  Pro Leu Gln Lys Arg  Met Ser Pro 
    5075                 5080                 5085             


Leu Asn  Val Tyr Pro Pro Gly  Glu Asn His Met Gly  Leu Ala Asp 
    5090                 5095                 5100             


Thr Lys  Ile Pro Arg Ser Gly  Thr Pro Val Ser Ile  Arg Ser Asn 
    5105                 5110                 5115             


Arg Ser  Ala Cys Val Leu Arg  Ile Pro Ser Gln Asn  Gln Thr Ser 
    5120                 5125                 5130             


Leu Thr  Tyr Ser Gln Gly Ser  Leu His Arg Ser Val  Ser Gln Leu 
    5135                 5140                 5145             


Met Asp  Ile Gln Asp Lys Lys  Val Leu Met Asp Asn  Ser Leu Trp 
    5150                 5155                 5160             


Glu Ala  Ile Met Gly His Asn  Ser Gly Leu Tyr Val  Asp Glu Glu 
    5165                 5170                 5175             


Asp Leu  Met Asn Ala Ile Lys  Asp Phe Ser Ser Val  Thr Lys Glu 
    5180                 5185                 5190             


Arg Thr  Thr Phe Thr Asp Thr  His Leu 
    5195                 5200         


<210> 224
<211> 1148
<212> PRT
<213> Homo sapiens

<400> 224
Met Glu Ser Leu Leu Leu Pro Val Leu Leu Leu Leu Ala Ile Leu Trp 
1               5                   10                  15      


Thr Gln Ala Ala Ala Leu Ile Asn Leu Lys Tyr Ser Val Glu Glu Glu 
            20                  25                  30          


Gln Arg Ala Gly Thr Val Ile Ala Asn Val Ala Lys Asp Ala Arg Glu 
        35                  40                  45              


Ala Gly Phe Ala Leu Asp Pro Arg Gln Ala Ser Ala Phe Arg Val Val 
    50                  55                  60                  


Ser Asn Ser Ala Pro His Leu Val Asp Ile Asn Pro Ser Ser Gly Leu 
65                  70                  75                  80  


Leu Val Thr Lys Gln Lys Ile Asp Arg Asp Leu Leu Cys Arg Gln Ser 
                85                  90                  95      


Pro Lys Cys Ile Ile Ser Leu Glu Val Met Ser Ser Ser Met Glu Ile 
            100                 105                 110         


Cys Val Ile Lys Val Glu Ile Lys Asp Leu Asn Asp Asn Ala Pro Ser 
        115                 120                 125             


Phe Pro Ala Ala Gln Ile Glu Leu Glu Ile Ser Glu Ala Ala Ser Pro 
    130                 135                 140                 


Gly Thr Arg Ile Pro Leu Asp Ser Ala Tyr Asp Pro Asp Ser Gly Ser 
145                 150                 155                 160 


Phe Gly Val Gln Thr Tyr Glu Leu Thr Pro Asn Glu Leu Phe Gly Leu 
                165                 170                 175     


Glu Ile Lys Thr Arg Gly Asp Gly Ser Arg Phe Ala Glu Leu Val Val 
            180                 185                 190         


Glu Lys Ser Leu Asp Arg Glu Thr Gln Ser His Tyr Ser Phe Arg Ile 
        195                 200                 205             


Thr Ala Leu Asp Gly Gly Asp Pro Pro Arg Leu Gly Thr Val Gly Leu 
    210                 215                 220                 


Ser Ile Lys Val Thr Asp Ser Asn Asp Asn Asn Pro Val Phe Ser Glu 
225                 230                 235                 240 


Ser Thr Tyr Ala Val Ser Val Pro Glu Asn Ser Pro Pro Asn Thr Pro 
                245                 250                 255     


Val Ile Arg Leu Asn Ala Ser Asp Pro Asp Glu Gly Thr Asn Gly Gln 
            260                 265                 270         


Val Val Tyr Ser Phe Tyr Gly Tyr Val Asn Asp Arg Thr Arg Glu Leu 
        275                 280                 285             


Phe Gln Ile Asp Pro His Ser Gly Leu Val Thr Val Thr Gly Ala Leu 
    290                 295                 300                 


Asp Tyr Glu Glu Gly His Val Tyr Glu Leu Asp Val Gln Ala Lys Asp 
305                 310                 315                 320 


Leu Gly Pro Asn Ser Ile Pro Ala His Cys Lys Val Thr Val Ser Val 
                325                 330                 335     


Leu Asp Thr Asn Asp Asn Pro Pro Val Ile Asn Leu Leu Ser Val Asn 
            340                 345                 350         


Ser Glu Leu Val Glu Val Ser Glu Ser Ala Pro Pro Gly Tyr Val Ile 
        355                 360                 365             


Ala Leu Val Arg Val Ser Asp Arg Asp Ser Gly Leu Asn Gly Arg Val 
    370                 375                 380                 


Gln Cys Arg Leu Leu Gly Asn Val Pro Phe Arg Leu Gln Glu Tyr Glu 
385                 390                 395                 400 


Ser Phe Ser Thr Ile Leu Val Asp Gly Arg Leu Asp Arg Glu Gln His 
                405                 410                 415     


Asp Gln Tyr Asn Leu Thr Ile Gln Ala Arg Asp Gly Gly Val Pro Met 
            420                 425                 430         


Leu Gln Ser Ala Lys Ser Phe Thr Val Leu Ile Thr Asp Glu Asn Asp 
        435                 440                 445             


Asn His Pro His Phe Ser Lys Pro Tyr Tyr Gln Val Ile Val Gln Glu 
    450                 455                 460                 


Asn Asn Thr Pro Gly Ala Tyr Leu Leu Ser Val Ser Ala Arg Asp Pro 
465                 470                 475                 480 


Asp Leu Gly Leu Asn Gly Ser Val Ser Tyr Gln Ile Val Pro Ser Gln 
                485                 490                 495     


Val Arg Asp Met Pro Val Phe Thr Tyr Val Ser Ile Asn Pro Asn Ser 
            500                 505                 510         


Gly Asp Ile Tyr Ala Leu Arg Ser Phe Asn His Glu Gln Thr Lys Ala 
        515                 520                 525             


Phe Glu Phe Lys Val Leu Ala Lys Asp Gly Gly Leu Pro Ser Leu Gln 
    530                 535                 540                 


Ser Asn Ala Thr Val Arg Val Ile Ile Leu Asp Val Asn Asp Asn Thr 
545                 550                 555                 560 


Pro Val Ile Thr Ala Pro Pro Leu Ile Asn Gly Thr Ala Glu Val Tyr 
                565                 570                 575     


Ile Pro Arg Asn Ser Gly Ile Gly Tyr Leu Val Thr Val Val Lys Ala 
            580                 585                 590         


Glu Asp Tyr Asp Glu Gly Glu Asn Gly Arg Val Thr Tyr Asp Met Thr 
        595                 600                 605             


Glu Gly Asp Arg Gly Phe Phe Glu Ile Asp Gln Val Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Thr Arg Thr Phe Gly Glu Ser Ser Lys Ser Ser Tyr Glu Leu 
625                 630                 635                 640 


Ile Val Val Ala His Asp His Gly Lys Thr Ser Leu Ser Ala Ser Ala 
                645                 650                 655     


Leu Val Leu Ile Tyr Leu Ser Pro Ala Leu Asp Ala Gln Glu Ser Met 
            660                 665                 670         


Gly Ser Val Asn Leu Ser Leu Ile Phe Ile Ile Ala Leu Gly Ser Ile 
        675                 680                 685             


Ala Gly Ile Leu Phe Val Thr Met Ile Phe Val Ala Ile Lys Cys Lys 
    690                 695                 700                 


Arg Asp Asn Lys Glu Ile Arg Thr Tyr Asn Cys Ser Asn Cys Leu Thr 
705                 710                 715                 720 


Ile Thr Cys Leu Leu Gly Cys Phe Ile Lys Gly Gln Asn Ser Lys Cys 
                725                 730                 735     


Leu His Cys Ile Ser Val Ser Pro Ile Ser Glu Glu Gln Asp Lys Lys 
            740                 745                 750         


Thr Glu Glu Lys Val Ser Leu Arg Gly Lys Arg Ile Ala Glu Tyr Ser 
        755                 760                 765             


Tyr Gly His Gln Lys Lys Ser Ser Lys Lys Lys Lys Ile Ser Lys Asn 
    770                 775                 780                 


Asp Ile Arg Leu Val Pro Arg Asp Val Glu Glu Thr Asp Lys Met Asn 
785                 790                 795                 800 


Val Val Ser Cys Ser Ser Leu Thr Ser Ser Leu Asn Tyr Phe Asp Tyr 
                805                 810                 815     


His Gln Gln Thr Leu Pro Leu Gly Cys Arg Arg Ser Glu Ser Thr Phe 
            820                 825                 830         


Leu Asn Val Glu Asn Gln Asn Thr Arg Asn Thr Ser Ala Asn His Ile 
        835                 840                 845             


Tyr His His Ser Phe Asn Ser Gln Gly Pro Gln Gln Pro Asp Leu Ile 
    850                 855                 860                 


Ile Asn Gly Val Pro Leu Pro Glu Thr Glu Asn Tyr Ser Phe Asp Ser 
865                 870                 875                 880 


Asn Tyr Val Asn Ser Arg Ala His Leu Ile Lys Ser Ser Ser Thr Phe 
                885                 890                 895     


Lys Asp Leu Glu Gly Asn Ser Leu Lys Asp Ser Gly His Glu Glu Ser 
            900                 905                 910         


Asp Gln Thr Asp Ser Glu His Asp Val Gln Arg Ser Leu Tyr Cys Asp 
        915                 920                 925             


Thr Ala Val Asn Asp Val Leu Asn Thr Ser Val Thr Ser Met Gly Ser 
    930                 935                 940                 


Gln Met Pro Asp His Asp Gln Asn Glu Gly Phe His Cys Arg Glu Glu 
945                 950                 955                 960 


Cys Arg Ile Leu Gly His Ser Asp Arg Cys Trp Met Pro Arg Asn Pro 
                965                 970                 975     


Met Pro Ile Arg Ser Lys Ser Pro Glu His Val Arg Asn Ile Ile Ala 
            980                 985                 990         


Leu Ser Ile Glu Ala Thr Ala Ala  Asp Val Glu Ala Tyr  Asp Asp Cys 
        995                 1000                 1005             


Gly Pro  Thr Lys Arg Thr Phe  Ala Thr Phe Gly Lys  Asp Val Ser 
    1010                 1015                 1020             


Asp His  Pro Ala Glu Glu Arg  Pro Thr Leu Lys Gly  Lys Arg Thr 
    1025                 1030                 1035             


Val Asp  Val Thr Ile Cys Ser  Pro Lys Val Asn Ser  Val Ile Arg 
    1040                 1045                 1050             


Glu Ala  Gly Asn Gly Cys Glu  Ala Ile Ser Pro Val  Thr Ser Pro 
    1055                 1060                 1065             


Leu His  Leu Lys Ser Ser Leu  Pro Thr Lys Pro Ser  Val Ser Tyr 
    1070                 1075                 1080             


Thr Ile  Ala Leu Ala Pro Pro  Ala Arg Asp Leu Glu  Gln Tyr Val 
    1085                 1090                 1095             


Asn Asn  Val Asn Asn Gly Pro  Thr Arg Pro Ser Glu  Ala Glu Pro 
    1100                 1105                 1110             


Arg Gly  Ala Asp Ser Glu Lys  Val Met His Glu Val  Ser Pro Ile 
    1115                 1120                 1125             


Leu Lys  Glu Gly Arg Asn Lys  Glu Ser Pro Gly Val  Lys Arg Leu 
    1130                 1135                 1140             


Lys Asp  Ile Val Leu 
    1145             


<210> 225
<211> 1807
<212> PRT
<213> Homo sapiens
      
<400> 225
Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Ser Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser 
945                 950                 955                 960 


Pro Pro Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg 
                965                 970                 975     


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            980                 985                 990         


Thr Ser Leu Thr Ser Ala Ser Leu  Gly Ser Ala Asp Glu  Asn Ser Val 
        995                 1000                 1005             


Ala Gln  Ala Asp Asp Ser Leu  Lys Asn Leu His Leu  Glu Leu Thr 
    1010                 1015                 1020             


Glu Thr  Cys Leu Asp Met Met  Ala Arg Tyr Val Phe  Ser Asn Phe 
    1025                 1030                 1035             


Thr Ala  Val Pro Lys Arg Ser  Pro Val Gly Glu Phe  Leu Leu Ala 
    1040                 1045                 1050             


Gly Gly  Arg Thr Lys Thr Trp  Leu Val Gly Asn Lys  Leu Val Thr 
    1055                 1060                 1065             


Val Thr  Thr Ser Val Gly Thr  Gly Thr Arg Ser Leu  Leu Gly Leu 
    1070                 1075                 1080             


Asp Ser  Gly Glu Leu Gln Ser  Gly Pro Glu Ser Ser  Ser Ser Pro 
    1085                 1090                 1095             


Gly Val  His Val Arg Gln Thr  Lys Glu Ala Pro Ala  Lys Leu Glu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Gln Gln Val  Ser Arg Gly Ala Arg  Asp Arg Val 
    1115                 1120                 1125             


Arg Ser  Met Ser Gly Gly His  Gly Leu Arg Val Gly  Ala Leu Asp 
    1130                 1135                 1140             


Val Pro  Ala Ser Gln Phe Leu  Gly Ser Ala Thr Ser  Pro Gly Pro 
    1145                 1150                 1155             


Arg Thr  Ala Pro Ala Ala Lys  Pro Glu Lys Ala Ser  Ala Gly Thr 
    1160                 1165                 1170             


Arg Val  Pro Val Gln Glu Lys  Thr Asn Leu Ala Ala  Tyr Val Pro 
    1175                 1180                 1185             


Leu Leu  Thr Gln Gly Trp Ala  Glu Ile Leu Val Arg  Arg Pro Thr 
    1190                 1195                 1200             


Gly Asn  Thr Ser Trp Leu Met  Ser Leu Glu Asn Pro  Leu Ser Pro 
    1205                 1210                 1215             


Phe Ser  Ser Asp Ile Asn Asn  Met Pro Leu Gln Glu  Leu Ser Asn 
    1220                 1225                 1230             


Ala Leu  Met Ala Ala Glu Arg  Phe Lys Glu His Arg  Asp Thr Ala 
    1235                 1240                 1245             


Leu Tyr  Lys Ser Leu Ser Val  Pro Ala Ala Ser Thr  Ala Lys Pro 
    1250                 1255                 1260             


Pro Pro  Leu Pro Arg Ser Asn  Thr Val Ala Ser Phe  Ser Ser Leu 
    1265                 1270                 1275             


Tyr Gln  Ser Ser Cys Gln Gly  Gln Leu His Arg Ser  Val Ser Trp 
    1280                 1285                 1290             


Ala Asp  Ser Ala Val Val Met  Glu Glu Gly Ser Pro  Gly Glu Val 
    1295                 1300                 1305             


Pro Val  Leu Val Glu Pro Pro  Gly Leu Glu Asp Val  Glu Ala Ala 
    1310                 1315                 1320             


Leu Gly  Met Asp Arg Arg Thr  Asp Ala Tyr Ser Arg  Ser Ser Ser 
    1325                 1330                 1335             


Val Ser  Ser Gln Glu Glu Lys  Ser Leu His Ala Glu  Glu Leu Val 
    1340                 1345                 1350             


Gly Arg  Gly Ile Pro Ile Glu  Arg Val Val Ser Ser  Glu Gly Gly 
    1355                 1360                 1365             


Arg Pro  Ser Val Asp Leu Ser  Phe Gln Pro Ser Gln  Pro Leu Ser 
    1370                 1375                 1380             


Lys Ser  Ser Ser Ser Pro Glu  Leu Gln Thr Leu Gln  Asp Ile Leu 
    1385                 1390                 1395             


Gly Asp  Pro Gly Asp Lys Ala  Asp Val Gly Arg Leu  Ser Pro Glu 
    1400                 1405                 1410             


Val Lys  Ala Arg Ser Gln Ser  Gly Thr Leu Asp Gly  Glu Ser Ala 
    1415                 1420                 1425             


Ala Trp  Ser Ala Ser Gly Glu  Asp Ser Arg Gly Gln  Pro Glu Gly 
    1430                 1435                 1440             


Pro Leu  Pro Ser Ser Ser Pro  Arg Ser Pro Ser Gly  Leu Arg Pro 
    1445                 1450                 1455             


Arg Gly  Tyr Thr Ile Ser Asp  Ser Ala Pro Ser Arg  Arg Gly Lys 
    1460                 1465                 1470             


Arg Val  Glu Arg Asp Ala Leu  Lys Ser Arg Ala Thr  Ala Ser Asn 
    1475                 1480                 1485             


Ala Glu  Lys Val Pro Gly Ile  Asn Pro Ser Phe Val  Phe Leu Gln 
    1490                 1495                 1500             


Leu Tyr  His Ser Pro Phe Phe  Gly Asp Glu Ser Asn  Lys Pro Ile 
    1505                 1510                 1515             


Leu Leu  Pro Asn Glu Ser Gln  Ser Phe Glu Arg Ser  Val Gln Leu 
    1520                 1525                 1530             


Leu Asp  Gln Ile Pro Ser Tyr  Asp Thr His Lys Ile  Ala Val Leu 
    1535                 1540                 1545             


Tyr Val  Gly Glu Gly Gln Ser  Asn Ser Glu Leu Ala  Ile Leu Ser 
    1550                 1555                 1560             


Asn Glu  His Gly Ser Tyr Arg  Tyr Thr Glu Phe Leu  Thr Gly Leu 
    1565                 1570                 1575             


Gly Arg  Leu Ile Glu Leu Lys  Asp Cys Gln Pro Asp  Lys Val Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Leu Asp Val Cys  Gly Glu Asp Gly Gln  Phe Thr Tyr 
    1595                 1600                 1605             


Cys Trp  His Asp Asp Ile Met  Gln Ala Val Phe His  Ile Ala Thr 
    1610                 1615                 1620             


Leu Met  Pro Thr Lys Asp Val  Asp Lys His Arg Cys  Asp Lys Lys 
    1625                 1630                 1635             


Arg His  Leu Gly Asn Asp Phe  Val Ser Ile Val Tyr  Asn Asp Ser 
    1640                 1645                 1650             


Gly Glu  Asp Phe Lys Leu Gly  Thr Ile Lys Gly Gln  Phe Asn Phe 
    1655                 1660                 1665             


Val His  Val Ile Val Thr Pro  Leu Asp Tyr Glu Cys  Asn Leu Val 
    1670                 1675                 1680             


Ser Leu  Gln Cys Arg Lys Asp  Met Glu Gly Leu Val  Asp Thr Ser 
    1685                 1690                 1695             


Val Ala  Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
    1700                 1705                 1710             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1715                 1720                 1725             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1730                 1735                 1740             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1745                 1750                 1755             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1760                 1765                 1770             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1775                 1780                 1785             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1790                 1795                 1800             


Thr Glu  Phe Val 
    1805         


<210> 226
<211> 1164
<212> PRT
<213> Homo sapiens
      
<400> 226
Met Ala Gln Gln Ala Asn Val Gly Glu Leu Leu Ala Met Leu Asp Ser 
1               5                   10                  15      


Pro Met Leu Gly Val Arg Asp Asp Val Thr Ala Val Phe Lys Glu Asn 
            20                  25                  30          


Leu Asn Ser Asp Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr 
        35                  40                  45              


Tyr Leu Glu Thr Ser Ser Gln Pro Ala Leu His Ile Leu Thr Thr Leu 
    50                  55                  60                  


Gln Glu Pro His Asp Lys His Leu Leu Asp Arg Ile Asn Glu Tyr Val 
65                  70                  75                  80  


Gly Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val 
                85                  90                  95      


Ile Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu 
            100                 105                 110         


Leu Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val 
        115                 120                 125             


Leu Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro 
    130                 135                 140                 


Gln Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg 
145                 150                 155                 160 


Leu Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Ala Glu Val Tyr 
                165                 170                 175     


Leu Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr 
            180                 185                 190         


Gly Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser 
        195                 200                 205             


Met Lys Glu Asn Leu Glu Thr Phe Glu Glu Val Val Lys Pro Met Met 
    210                 215                 220                 


Glu His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His 
225                 230                 235                 240 


Glu Leu Asp Pro Arg Arg Trp Lys Arg Leu Glu Thr His Asp Val Val 
                245                 250                 255     


Ile Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu 
            260                 265                 270         


Asp Gly Tyr Ser Val Ser His Gln Ile Ser Ala Arg Phe Pro His Arg 
        275                 280                 285             


Ser Ala Asp Val Thr Thr Ser Pro Tyr Ala Asp Thr Gln Asn Ser Tyr 
    290                 295                 300                 


Gly Cys Ala Thr Ser Thr Pro Tyr Ser Thr Ser Arg Leu Met Leu Leu 
305                 310                 315                 320 


Asn Met Pro Gly Gln Leu Pro Gln Thr Leu Ser Ser Pro Ser Thr Arg 
                325                 330                 335     


Leu Ile Thr Glu Pro Pro Gln Ala Thr Leu Trp Ser Pro Ser Met Val 
            340                 345                 350         


Cys Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Pro Asp 
        355                 360                 365             


Leu Ser His Pro Tyr Ser Lys Val Phe Gly Thr Thr Ala Gly Gly Lys 
    370                 375                 380                 


Gly Thr Pro Leu Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Leu 
385                 390                 395                 400 


Cys His Ser Asp Asp Tyr Val His Ile Ser Leu Pro Gln Ala Thr Val 
                405                 410                 415     


Thr Pro Pro Arg Lys Glu Glu Arg Met Asp Ser Ala Arg Pro Cys Leu 
            420                 425                 430         


His Arg Gln His His Leu Leu Asn Asp Arg Gly Ser Glu Glu Pro Pro 
        435                 440                 445             


Gly Ser Lys Gly Ser Val Thr Leu Ser Asp Leu Pro Gly Phe Leu Gly 
    450                 455                 460                 


Asp Leu Ala Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala 
465                 470                 475                 480 


Ala Ile Ser Arg Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Glu Pro 
                485                 490                 495     


Val Val Pro Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu 
            500                 505                 510         


Pro Gly Ser Gln Arg Lys Thr His Ser Ala Ala Ser Ser Ser Gln Gly 
        515                 520                 525             


Ala Ser Val Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys Leu Gly 
    530                 535                 540                 


Pro Asp Thr Pro Lys Gln Ala Phe Thr Pro Ile Asp Leu Pro Cys Gly 
545                 550                 555                 560 


Ser Ala Asp Glu Ser Pro Ala Gly Asp Arg Glu Cys Gln Thr Ser Leu 
                565                 570                 575     


Glu Thr Ser Ile Phe Thr Pro Ser Pro Cys Lys Ile Pro Pro Pro Thr 
            580                 585                 590         


Arg Val Gly Phe Gly Ser Gly Gln Pro Pro Pro Tyr Asp His Leu Phe 
        595                 600                 605             


Glu Val Ala Leu Pro Lys Thr Ala His His Phe Val Ile Arg Lys Thr 
    610                 615                 620                 


Glu Glu Leu Leu Lys Lys Ala Lys Gly Asn Thr Glu Glu Asp Gly Val 
625                 630                 635                 640 


Pro Ser Thr Ser Pro Met Glu Val Leu Asp Arg Leu Ile Gln Gln Gly 
                645                 650                 655     


Ala Asp Ala His Ser Lys Glu Leu Asn Lys Leu Pro Leu Pro Ser Lys 
            660                 665                 670         


Ser Val Asp Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Ile 
        675                 680                 685             


Arg Thr Leu Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr 
    690                 695                 700                 


Glu Arg Phe Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu 
705                 710                 715                 720 


Arg Lys Val Ile Lys Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met 
                725                 730                 735     


Lys Asp Gln Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val 
            740                 745                 750         


Ser Leu Gln Lys Glu Gln Ala Arg Tyr Asn Gln Leu Gln Glu Gln Arg 
        755                 760                 765             


Asp Thr Met Val Thr Lys Leu His Ser Gln Ile Arg Gln Leu Gln His 
    770                 775                 780                 


Asp Arg Glu Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu 
785                 790                 795                 800 


Glu Asp Cys Arg Asn Met Ile Ala Glu Leu Arg Ile Glu Leu Lys Lys 
                805                 810                 815     


Ala Asn Asn Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser 
            820                 825                 830         


Gln Lys Leu Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu 
        835                 840                 845             


Asn Arg Gln Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu 
    850                 855                 860                 


Gln Leu Gln Asn Lys His Ser Asp Thr Thr Lys Glu Val Glu Met Met 
865                 870                 875                 880 


Lys Ala Ala Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Val Leu 
                885                 890                 895     


Gln Gln Thr Gln Arg Leu Asp Thr Ser Gln Lys Arg Ile Leu Glu Leu 
            900                 905                 910         


Glu Ser His Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys 
        915                 920                 925             


Tyr Leu Glu Asp Val Lys Leu Gln Ala Arg Gly Gln Leu Gln Ala Ala 
    930                 935                 940                 


Glu Ser Arg Tyr Glu Ala Gln Lys Arg Ile Thr Gln Val Phe Glu Leu 
945                 950                 955                 960 


Glu Ile Leu Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Leu Leu Lys 
                965                 970                 975     


Lys Leu Glu Glu Glu Lys Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg 
            980                 985                 990         


Leu Asp Cys Cys Asn Asp Gly Cys  Ser Asp Ser Met Val  Gly His Asn 
        995                 1000                 1005             


Glu Glu  Ala Ser Gly His Asn  Gly Glu Thr Lys Thr  Pro Arg Pro 
    1010                 1015                 1020             


Ser Ser  Ala Arg Gly Ser Ser  Gly Ser Arg Gly Gly  Gly Gly Ser 
    1025                 1030                 1035             


Ser Ser  Ser Ser Ser Glu Leu  Ser Thr Pro Glu Lys  Pro Pro His 
    1040                 1045                 1050             


Gln Arg  Ala Gly Pro Phe Ser  Ser Arg Trp Glu Thr  Thr Met Gly 
    1055                 1060                 1065             


Glu Ala  Ser Ala Ser Ile Pro  Thr Thr Val Gly Ser  Leu Pro Ser 
    1070                 1075                 1080             


Ser Lys  Ser Phe Leu Gly Met  Lys Ala Arg Glu Leu  Phe Arg Asn 
    1085                 1090                 1095             


Lys Ser  Glu Ser Gln Cys Asp  Glu Asp Gly Met Thr  Ser Ser Leu 
    1100                 1105                 1110             


Ser Glu  Ser Leu Lys Thr Glu  Leu Gly Lys Asp Leu  Gly Val Glu 
    1115                 1120                 1125             


Ala Lys  Ile Pro Leu Asn Leu  Asp Gly Pro His Pro  Ser Pro Pro 
    1130                 1135                 1140             


Thr Pro  Asp Ser Val Gly Gln  Leu His Ile Met Asp  Tyr Asn Glu 
    1145                 1150                 1155             


Thr His  His Glu His Ser 
    1160                 


<210> 227
<211> 3685
<212> PRT
<213> Homo sapiens

<400> 227
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Lys Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210> 228
<211> 1484
<212> PRT
<213> Homo sapiens

<400> 228
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 


Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 


Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     


Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         


Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             


Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 


Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 


Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     


Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         


Ser Ile Gly Ser Ala Ser Ser Ile  Asp Gly Leu Tyr Asp  Cys Asp Asn 
        995                 1000                 1005             


Pro Pro  Phe Thr Thr Gln Ser  Arg Ser Ile Ser Lys  Lys Pro Leu 
    1010                 1015                 1020             


Asp Ile  Gly Leu Pro Ser Ser  Lys His Ser Gln Leu  Ser Asp Leu 
    1025                 1030                 1035             


Tyr Gly  Lys Phe Ser Phe Lys  Ser Asp Arg Tyr Ser  Gly His Asp 
    1040                 1045                 1050             


Asp Leu  Ile Arg Ser Asp Val  Ser Asp Ile Ser Thr  His Thr Val 
    1055                 1060                 1065             


Thr Tyr  Gly Asn Ile Glu Gly  Asn Ala Ala Lys Arg  Arg Lys Gln 
    1070                 1075                 1080             


Gln Tyr  Lys Asp Ser Leu Lys  Lys Arg Pro Ala Ser  Ala Lys Ser 
    1085                 1090                 1095             


Arg Arg  Glu Phe Asp Glu Ile  Glu Leu Ala Tyr Arg  Arg Arg Pro 
    1100                 1105                 1110             


Pro Arg  Ser Pro Asp His Lys  Arg Tyr Phe Arg Asp  Lys Glu Gly 
    1115                 1120                 1125             


Leu Arg  Asp Phe Tyr Leu Asp  Gln Phe Arg Thr Lys  Glu Asn Ser 
    1130                 1135                 1140             


Pro His  Trp Glu His Val Asp  Leu Thr Asp Ile Tyr  Lys Glu Arg 
    1145                 1150                 1155             


Ser Asp  Asp Phe Lys Arg Asp  Ser Val Ser Gly Gly  Gly Pro Cys 
    1160                 1165                 1170             


Thr Asn  Arg Ser His Ile Lys  His Gly Thr Gly Asp  Lys His Gly 
    1175                 1180                 1185             


Val Val  Ser Gly Val Pro Ala  Pro Trp Glu Lys Asn  Leu Thr Asn 
    1190                 1195                 1200             


Val Glu  Trp Glu Asp Arg Ser  Gly Gly Asn Phe Cys  Arg Ser Cys 
    1205                 1210                 1215             


Pro Ser  Lys Leu His Asn Tyr  Ser Thr Thr Val Thr  Gly Gln Asn 
    1220                 1225                 1230             


Ser Gly  Arg Gln Ala Cys Ile  Arg Cys Glu Ala Cys  Lys Lys Ala 
    1235                 1240                 1245             


Gly Asn  Leu Tyr Asp Ile Ser  Glu Asp Asn Ser Leu  Gln Glu Leu 
    1250                 1255                 1260             


Asp Gln  Pro Ala Ala Pro Val  Ala Val Thr Ser Asn  Ala Ser Thr 
    1265                 1270                 1275             


Thr Lys  Tyr Pro Gln Ser Pro  Thr Asn Ser Lys Ala  Gln Lys Lys 
    1280                 1285                 1290             


Asn Arg  Asn Lys Leu Arg Arg  Gln His Ser Tyr Asp  Thr Phe Val 
    1295                 1300                 1305             


Asp Leu  Gln Lys Glu Glu Ala  Ala Leu Ala Pro Arg  Ser Val Ser 
    1310                 1315                 1320             


Leu Lys  Asp Lys Gly Arg Phe  Met Asp Gly Ser Pro  Tyr Ala His 
    1325                 1330                 1335             


Met Phe  Glu Met Ser Ala Gly  Glu Ser Thr Phe Ala  Asn Asn Lys 
    1340                 1345                 1350             


Ser Ser  Val Pro Thr Ala Gly  His His His His Asn  Asn Pro Gly 
    1355                 1360                 1365             


Gly Gly  Tyr Met Leu Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr 
    1370                 1375                 1380             


Gln Asn  Pro Phe Ile Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu 
    1385                 1390                 1395             


His Gly  Ser Lys Ser Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly 
    1400                 1405                 1410             


Ala Ser  Lys Ala Arg Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys 
    1415                 1420                 1425             


Pro Val  Val Ser Ala Leu His  Gly Ala Val Pro Ala  Arg Phe Gln 
    1430                 1435                 1440             


Lys Asp  Ile Cys Ile Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn 
    1445                 1450                 1455             


Asn Lys  Asn Pro Arg Ala Phe  Asn Gly Ser Ser Asn  Gly His Val 
    1460                 1465                 1470             


Tyr Glu  Lys Leu Ser Ser Ile  Glu Ser Asp Val 
    1475                 1480                 


<210> 229
<211> 1480
<212> PRT
<213> Homo sapiens

<400> 229
Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


<210> 230
<211> 2009
<212> PRT
<213> Homo sapiens

<400> 230
Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Ala Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys 
    2000                 2005                 


<210> 231
<211> 1465
<212> PRT
<213> Homo sapiens

<400> 231
Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu 
    610                 615                 620                 


Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His 
625                 630                 635                 640 


Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys 
                645                 650                 655     


Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu 
            660                 665                 670         


Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile 
        675                 680                 685             


Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr 
    690                 695                 700                 


Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys 
705                 710                 715                 720 


Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala 
                725                 730                 735     


Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val 
            740                 745                 750         


Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro 
        755                 760                 765             


Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala 
    770                 775                 780                 


Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala 
785                 790                 795                 800 


Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg 
                805                 810                 815     


Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys 
            820                 825                 830         


Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly 
        835                 840                 845             


Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val 
    850                 855                 860                 


Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His 
865                 870                 875                 880 


Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu 
                885                 890                 895     


Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro 
            900                 905                 910         


Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile 
        915                 920                 925             


Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe 
    930                 935                 940                 


Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His 
945                 950                 955                 960 


Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile 
                965                 970                 975     


Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro 
            980                 985                 990         


Thr Ala Val Met Val Gly Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu 
        995                 1000                 1005             


Ile Lys  Gly Gly Lys Pro Leu  Glu Met Ala His Lys  Ile Lys Thr 
    1010                 1015                 1020             


Val Met  Phe Asp Lys Thr Gly  Thr Ile Thr His Gly  Val Pro Arg 
    1025                 1030                 1035             


Val Met  Arg Val Leu Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu 
    1040                 1045                 1050             


Arg Lys  Val Leu Ala Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu 
    1055                 1060                 1065             


His Pro  Leu Gly Val Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu 
    1070                 1075                 1080             


Gly Thr  Glu Thr Leu Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro 
    1085                 1090                 1095             


Gly Cys  Gly Ile Gly Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu 
    1100                 1105                 1110             


Ala His  Ser Glu Arg Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn 
    1115                 1120                 1125             


Glu Ala  Gly Ser Leu Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr 
    1130                 1135                 1140             


Phe Ser  Val Leu Ile Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly 
    1145                 1150                 1155             


Leu Thr  Ile Ser Ser Asp Val  Ser Asp Ala Met Thr  Asp His Glu 
    1160                 1165                 1170             


Met Lys  Gly Gln Thr Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu 
    1175                 1180                 1185             


Cys Gly  Met Ile Ala Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala 
    1190                 1195                 1200             


Leu Ala  Val His Thr Leu Gln  Ser Met Gly Val Asp  Val Val Leu 
    1205                 1210                 1215             


Ile Thr  Gly Asp Asn Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln 
    1220                 1225                 1230             


Val Gly  Ile Asn Lys Val Phe  Ala Glu Val Leu Pro  Ser His Lys 
    1235                 1240                 1245             


Val Ala  Lys Val Gln Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala 
    1250                 1255                 1260             


Met Val  Gly Asp Gly Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala 
    1265                 1270                 1275             


Asp Met  Gly Val Ala Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu 
    1280                 1285                 1290             


Ala Ala  Asp Val Val Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val 
    1295                 1300                 1305             


Ala Ser  Ile His Leu Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile 
    1310                 1315                 1320             


Asn Leu  Val Leu Ala Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile 
    1325                 1330                 1335             


Ala Ala  Gly Val Phe Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp 
    1340                 1345                 1350             


Met Gly  Ser Ala Ala Met Ala  Ala Ser Ser Val Ser  Val Val Leu 
    1355                 1360                 1365             


Ser Ser  Leu Gln Leu Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg 
    1370                 1375                 1380             


Tyr Glu  Ala Gln Ala His Gly  His Met Lys Pro Leu  Thr Ala Ser 
    1385                 1390                 1395             


Gln Val  Ser Val His Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser 
    1400                 1405                 1410             


Pro Arg  Ala Thr Pro Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val 
    1415                 1420                 1425             


Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala 
    1430                 1435                 1440             


Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly 
    1445                 1450                 1455             


Arg Asp  Glu Glu Gln Tyr Ile  
    1460                 1465 


<210> 232
<211> 872
<212> PRT
<213> Homo sapiens

<400> 232
Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Ser Ser Gln Thr Gln Thr Tyr Gly Ala Ser Arg Leu 
    370                 375                 380                 


Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu Arg Asn Leu Lys Ser Lys 
385                 390                 395                 400 


Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro Pro Glu Pro Ser Pro Ser 
                405                 410                 415     


Lys Gly Ser Pro Cys Arg Gly Pro Leu Cys Gly Cys Cys Pro Gly Arg 
            420                 425                 430         


Ser Ser Gln Lys Val Ser Leu Lys Asp Arg Val Phe Ser Ser Pro Arg 
        435                 440                 445             


Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala Gln Thr Val Arg 
    450                 455                 460                 


Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser Pro Ser Lys Val 
465                 470                 475                 480 


Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala Arg Gln Ala Phe 
                485                 490                 495     


Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu Glu Ala Ser Leu 
            500                 505                 510         


Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro Cys Glu Phe Val 
        515                 520                 525             


Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile Arg Ala Val Cys 
    530                 535                 540                 


Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys Glu Ser Leu Arg 
545                 550                 555                 560 


Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu 
                565                 570                 575     


Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg Val Asp Gln Ile 
            580                 585                 590         


Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg Thr Lys Gly Pro 
        595                 600                 605             


Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met Gly Arg Leu Gly 
    610                 615                 620                 


Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys Leu Asp Phe Leu 
625                 630                 635                 640 


Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro Thr Glu Thr Glu 
                645                 650                 655     


Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro Pro Tyr His Ser 
            660                 665                 670         


Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly Cys Ile Val Lys 
        675                 680                 685             


Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn Phe Ser Ala Pro 
    690                 695                 700                 


Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr Ser Trp Gln Pro 
705                 710                 715                 720 


Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro Val Gly Asp His 
                725                 730                 735     


Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His Glu Arg Ser Leu 
            740                 745                 750         


Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu Phe Leu Arg Gln 
        755                 760                 765             


Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn Leu Arg Asp Ser 
    770                 775                 780                 


Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu Glu Leu Glu Arg 
785                 790                 795                 800 


Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu Asn Leu Asp Ala 
                805                 810                 815     


Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala Lys Val Arg Pro 
            820                 825                 830         


Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp Leu Cys Thr Pro 
        835                 840                 845             


Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly Pro Phe Gly Asp 
    850                 855                 860                 


Val Gly Trp Ala Gly Pro Arg Lys 
865                 870         


<210> 233
<211> 2005
<212> PRT
<213> Homo sapiens

<400> 233
Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  
    2000                 2005 


<210> 234
<211> 2506
<212> PRT
<213> Homo sapiens

<400> 234
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp Leu 
            420                 425                 430         


Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser Val 
        435                 440                 445             


Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu Asn 
    450                 455                 460                 


Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile Arg 
465                 470                 475                 480 


Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu Val 
                485                 490                 495     


Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro Glu 
            500                 505                 510         


Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly Leu 
        515                 520                 525             


Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg Pro 
    530                 535                 540                 


Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile Gly 
545                 550                 555                 560 


Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser Phe 
                565                 570                 575     


Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val 
            580                 585                 590         


Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn 
        595                 600                 605             


Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile 
    610                 615                 620                 


Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn 
625                 630                 635                 640 


Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala Ala 
                645                 650                 655     


Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu Val 
            660                 665                 670         


Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met Val 
        675                 680                 685             


Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu 
    690                 695                 700                 


Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln 
705                 710                 715                 720 


Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln Lys 
                725                 730                 735     


Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu Ser 
            740                 745                 750         


Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln Lys 
        755                 760                 765             


Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys Gln 
    770                 775                 780                 


Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro Asp 
785                 790                 795                 800 


Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met Lys 
                805                 810                 815     


Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg Asn 
            820                 825                 830         


Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln Arg 
        835                 840                 845             


Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg Tyr 
    850                 855                 860                 


His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala Arg 
865                 870                 875                 880 


Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly Pro 
                885                 890                 895     


Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu Gln 
            900                 905                 910         


Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp Pro 
        915                 920                 925             


His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg Ser 
    930                 935                 940                 


Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg Ala 
945                 950                 955                 960 


His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg Arg 
                965                 970                 975     


Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly Glu 
            980                 985                 990         


Gly Glu Gly Pro Asp Gly Gly Glu  Arg Arg Arg Arg His  Arg His Gly 
        995                 1000                 1005             


Ala Pro  Ala Thr Tyr Glu Gly  Asp Ala Arg Arg Glu  Asp Lys Glu 
    1010                 1015                 1020             


Arg Arg  His Arg Arg Arg Lys  Glu Asn Gln Gly Ser  Gly Val Pro 
    1025                 1030                 1035             


Val Ser  Gly Pro Asn Leu Ser  Thr Thr Arg Pro Ile  Gln Gln Asp 
    1040                 1045                 1050             


Leu Gly  Arg Gln Asp Pro Pro  Leu Ala Glu Asp Ile  Asp Asn Met 
    1055                 1060                 1065             


Lys Asn  Asn Lys Leu Ala Thr  Ala Glu Ser Ala Ala  Pro His Gly 
    1070                 1075                 1080             


Ser Leu  Gly His Ala Gly Leu  Pro Gln Ser Pro Ala  Lys Met Gly 
    1085                 1090                 1095             


Asn Ser  Thr Asp Pro Gly Pro  Met Leu Ala Ile Pro  Ala Met Ala 
    1100                 1105                 1110             


Thr Asn  Pro Gln Asn Ala Ala  Ser Arg Arg Thr Pro  Asn Asn Pro 
    1115                 1120                 1125             


Gly Asn  Pro Ser Asn Pro Gly  Pro Pro Lys Thr Pro  Glu Asn Ser 
    1130                 1135                 1140             


Leu Ile  Val Thr Asn Pro Ser  Gly Thr Gln Thr Asn  Ser Ala Lys 
    1145                 1150                 1155             


Thr Ala  Arg Lys Pro Asp His  Thr Thr Val Asp Ile  Pro Pro Ala 
    1160                 1165                 1170             


Cys Pro  Pro Pro Leu Asn His  Thr Val Val Gln Val  Asn Lys Asn 
    1175                 1180                 1185             


Ala Asn  Pro Asp Pro Leu Pro  Lys Lys Glu Glu Glu  Lys Lys Glu 
    1190                 1195                 1200             


Glu Glu  Glu Asp Asp Arg Gly  Glu Asp Gly Pro Lys  Pro Met Pro 
    1205                 1210                 1215             


Pro Tyr  Ser Ser Met Phe Ile  Leu Ser Thr Thr Asn  Pro Leu Arg 
    1220                 1225                 1230             


Arg Leu  Cys His Tyr Ile Leu  Asn Leu Arg Tyr Phe  Glu Met Cys 
    1235                 1240                 1245             


Ile Leu  Met Val Ile Ala Met  Ser Ser Ile Ala Leu  Ala Ala Glu 
    1250                 1255                 1260             


Asp Pro  Val Gln Pro Asn Ala  Pro Arg Asn Asn Val  Leu Arg Tyr 
    1265                 1270                 1275             


Phe Asp  Tyr Val Phe Thr Gly  Val Phe Thr Phe Glu  Met Val Ile 
    1280                 1285                 1290             


Lys Met  Ile Asp Leu Gly Leu  Val Leu His Gln Gly  Ala Tyr Phe 
    1295                 1300                 1305             


Arg Asp  Leu Trp Asn Ile Leu  Asp Phe Ile Val Val  Ser Gly Ala 
    1310                 1315                 1320             


Leu Val  Ala Phe Ala Phe Thr  Gly Asn Ser Lys Gly  Lys Asp Ile 
    1325                 1330                 1335             


Asn Thr  Ile Lys Ser Leu Arg  Val Leu Arg Val Leu  Arg Pro Leu 
    1340                 1345                 1350             


Lys Thr  Ile Lys Arg Leu Pro  Lys Leu Lys Ala Val  Phe Asp Cys 
    1355                 1360                 1365             


Val Val  Asn Ser Leu Lys Asn  Val Phe Asn Ile Leu  Ile Val Tyr 
    1370                 1375                 1380             


Met Leu  Phe Met Phe Ile Phe  Ala Val Val Ala Val  Gln Leu Phe 
    1385                 1390                 1395             


Lys Gly  Lys Phe Phe His Cys  Thr Asp Glu Ser Lys  Glu Phe Glu 
    1400                 1405                 1410             


Lys Asp  Cys Arg Gly Lys Tyr  Leu Leu Tyr Glu Lys  Asn Glu Val 
    1415                 1420                 1425             


Lys Ala  Arg Asp Arg Glu Trp  Lys Lys Tyr Glu Phe  His Tyr Asp 
    1430                 1435                 1440             


Asn Val  Leu Trp Ala Leu Leu  Thr Leu Phe Thr Val  Ser Thr Gly 
    1445                 1450                 1455             


Glu Gly  Trp Pro Gln Val Leu  Lys His Ser Val Asp  Ala Thr Phe 
    1460                 1465                 1470             


Glu Asn  Gln Gly Pro Ser Pro  Gly Tyr Arg Met Glu  Met Ser Ile 
    1475                 1480                 1485             


Phe Tyr  Val Val Tyr Phe Val  Val Phe Pro Phe Phe  Phe Val Asn 
    1490                 1495                 1500             


Ile Phe  Val Ala Leu Ile Ile  Ile Thr Phe Gln Glu  Gln Gly Asp 
    1505                 1510                 1515             


Lys Met  Met Glu Glu Tyr Ser  Leu Glu Lys Asn Glu  Arg Ala Cys 
    1520                 1525                 1530             


Ile Asp  Phe Ala Ile Ser Ala  Lys Pro Leu Thr Arg  His Met Pro 
    1535                 1540                 1545             


Gln Asn  Lys Gln Ser Phe Gln  Tyr Arg Met Trp Gln  Phe Val Val 
    1550                 1555                 1560             


Ser Pro  Pro Phe Glu Tyr Thr  Ile Met Ala Met Ile  Ala Leu Asn 
    1565                 1570                 1575             


Thr Ile  Val Leu Met Met Lys  Phe Tyr Gly Ala Ser  Val Ala Tyr 
    1580                 1585                 1590             


Glu Asn  Ala Leu Arg Val Phe  Asn Ile Val Phe Thr  Ser Leu Phe 
    1595                 1600                 1605             


Ser Leu  Glu Cys Val Leu Lys  Val Met Ala Phe Gly  Ile Leu Asn 
    1610                 1615                 1620             


Tyr Phe  Arg Asp Ala Trp Asn  Ile Phe Asp Phe Val  Thr Val Leu 
    1625                 1630                 1635             


Gly Ser  Ile Thr Asp Ile Leu  Val Thr Glu Phe Gly  Asn Asn Phe 
    1640                 1645                 1650             


Ile Asn  Leu Ser Phe Leu Arg  Leu Phe Arg Ala Ala  Arg Leu Ile 
    1655                 1660                 1665             


Lys Leu  Leu Arg Gln Gly Tyr  Thr Ile Arg Ile Leu  Leu Trp Thr 
    1670                 1675                 1680             


Phe Val  Gln Ser Phe Lys Ala  Leu Pro Tyr Val Cys  Leu Leu Ile 
    1685                 1690                 1695             


Ala Met  Leu Phe Phe Ile Tyr  Ala Ile Ile Gly Met  Gln Val Phe 
    1700                 1705                 1710             


Gly Asn  Ile Gly Ile Asp Val  Glu Asp Glu Asp Ser  Asp Glu Asp 
    1715                 1720                 1725             


Glu Phe  Gln Ile Thr Glu His  Asn Asn Phe Arg Thr  Phe Phe Gln 
    1730                 1735                 1740             


Ala Leu  Met Leu Leu Phe Arg  Ser Ala Thr Gly Glu  Ala Trp His 
    1745                 1750                 1755             


Asn Ile  Met Leu Ser Cys Leu  Ser Gly Lys Pro Cys  Asp Lys Asn 
    1760                 1765                 1770             


Ser Gly  Ile Leu Thr Arg Glu  Cys Gly Asn Glu Phe  Ala Tyr Phe 
    1775                 1780                 1785             


Tyr Phe  Val Ser Phe Ile Phe  Leu Cys Ser Phe Leu  Met Leu Asn 
    1790                 1795                 1800             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Glu Tyr  Leu Thr Arg 
    1805                 1810                 1815             


Asp Ser  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Tyr Val Arg 
    1820                 1825                 1830             


Val Trp  Ala Glu Tyr Asp Pro  Ala Ala Trp Gly Arg  Met Pro Tyr 
    1835                 1840                 1845             


Leu Asp  Met Tyr Gln Met Leu  Arg His Met Ser Pro  Pro Leu Gly 
    1850                 1855                 1860             


Leu Gly  Lys Lys Cys Pro Ala  Arg Val Ala Tyr Lys  Arg Leu Leu 
    1865                 1870                 1875             


Arg Met  Asp Leu Pro Val Ala  Asp Asp Asn Thr Val  His Phe Asn 
    1880                 1885                 1890             


Ser Thr  Leu Met Ala Leu Ile  Arg Thr Ala Leu Asp  Ile Lys Ile 
    1895                 1900                 1905             


Ala Lys  Gly Gly Ala Asp Lys  Gln Gln Met Asp Ala  Glu Leu Arg 
    1910                 1915                 1920             


Lys Glu  Met Met Ala Ile Trp  Pro Asn Leu Ser Gln  Lys Thr Leu 
    1925                 1930                 1935             


Asp Leu  Leu Val Thr Pro His  Lys Ser Thr Asp Leu  Thr Val Gly 
    1940                 1945                 1950             


Lys Ile  Tyr Ala Ala Met Met  Ile Met Glu Tyr Tyr  Arg Gln Ser 
    1955                 1960                 1965             


Lys Ala  Lys Lys Leu Gln Ala  Met Arg Glu Glu Gln  Asp Arg Thr 
    1970                 1975                 1980             


Pro Leu  Met Phe Gln Arg Met  Glu Pro Pro Ser Pro  Thr Gln Glu 
    1985                 1990                 1995             


Gly Gly  Pro Gly Gln Asn Ala  Leu Pro Ser Thr Gln  Leu Asp Pro 
    2000                 2005                 2010             


Gly Gly  Ala Leu Met Ala His  Glu Ser Gly Leu Lys  Glu Ser Pro 
    2015                 2020                 2025             


Ser Trp  Val Thr Gln Arg Ala  Gln Glu Met Phe Gln  Lys Thr Gly 
    2030                 2035                 2040             


Thr Trp  Ser Pro Glu Gln Gly  Pro Pro Thr Asp Met  Pro Asn Ser 
    2045                 2050                 2055             


Gln Pro  Asn Ser Gln Ser Val  Glu Met Arg Glu Met  Gly Arg Asp 
    2060                 2065                 2070             


Gly Tyr  Ser Asp Ser Glu His  Tyr Leu Pro Met Glu  Gly Gln Gly 
    2075                 2080                 2085             


Arg Ala  Ala Ser Met Pro Arg  Leu Pro Ala Glu Asn  Gln Arg Arg 
    2090                 2095                 2100             


Arg Gly  Arg Pro Arg Gly Asn  Asn Leu Ser Thr Ile  Ser Asp Thr 
    2105                 2110                 2115             


Ser Pro  Met Lys Arg Ser Ala  Ser Val Leu Gly Pro  Lys Ala Arg 
    2120                 2125                 2130             


Arg Leu  Asp Asp Tyr Ser Leu  Glu Arg Val Pro Pro  Glu Glu Asn 
    2135                 2140                 2145             


Gln Arg  His His Gln Arg Arg  Arg Asp Arg Ser His  Arg Ala Ser 
    2150                 2155                 2160             


Glu Arg  Ser Leu Gly Arg Tyr  Thr Asp Val Asp Thr  Gly Leu Gly 
    2165                 2170                 2175             


Thr Asp  Leu Ser Met Thr Thr  Gln Ser Gly Asp Leu  Pro Ser Lys 
    2180                 2185                 2190             


Glu Arg  Asp Gln Glu Arg Gly  Arg Pro Lys Asp Arg  Lys His Arg 
    2195                 2200                 2205             


Gln His  His His His His His  His His His His Pro  Pro Pro Pro 
    2210                 2215                 2220             


Asp Lys  Asp Arg Tyr Ala Gln  Glu Arg Pro Asp His  Gly Arg Ala 
    2225                 2230                 2235             


Arg Ala  Arg Asp Gln Arg Trp  Ser Arg Ser Pro Ser  Glu Gly Arg 
    2240                 2245                 2250             


Glu His  Met Ala His Arg Gln  Gly Ser Ser Ser Val  Ser Gly Ser 
    2255                 2260                 2265             


Pro Ala  Pro Ser Thr Ser Gly  Thr Ser Thr Pro Arg  Arg Gly Arg 
    2270                 2275                 2280             


Arg Gln  Leu Pro Gln Thr Pro  Ser Thr Pro Arg Pro  His Val Ser 
    2285                 2290                 2295             


Tyr Ser  Pro Val Ile Arg Lys  Ala Gly Gly Ser Gly  Pro Pro Gln 
    2300                 2305                 2310             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Ala Val Ala 
    2315                 2320                 2325             


Arg Pro  Gly Arg Ala Ala Thr  Ser Gly Pro Arg Arg  Tyr Pro Gly 
    2330                 2335                 2340             


Pro Thr  Ala Glu Pro Leu Ala  Gly Asp Arg Pro Pro  Thr Gly Gly 
    2345                 2350                 2355             


His Ser  Ser Gly Arg Ser Pro  Arg Met Glu Arg Arg  Val Pro Gly 
    2360                 2365                 2370             


Pro Ala  Arg Ser Glu Ser Pro  Arg Ala Cys Arg His  Gly Gly Ala 
    2375                 2380                 2385             


Arg Trp  Pro Ala Ser Gly Pro  His Val Ser Glu Gly  Pro Pro Gly 
    2390                 2395                 2400             


Pro Arg  His His Gly Tyr Tyr  Arg Gly Ser Asp Tyr  Asp Glu Ala 
    2405                 2410                 2415             


Asp Gly  Pro Gly Ser Gly Gly  Gly Glu Glu Ala Met  Ala Gly Ala 
    2420                 2425                 2430             


Tyr Asp  Ala Pro Pro Pro Val  Arg His Ala Ser Ser  Gly Ala Thr 
    2435                 2440                 2445             


Gly Arg  Ser Pro Arg Thr Pro  Arg Ala Ser Gly Pro  Ala Cys Ala 
    2450                 2455                 2460             


Ser Pro  Ser Arg His Gly Arg  Arg Leu Pro Asn Gly  Tyr Tyr Pro 
    2465                 2470                 2475             


Ala His  Gly Leu Ala Arg Pro  Arg Gly Pro Gly Ser  Arg Lys Gly 
    2480                 2485                 2490             


Leu His  Glu Pro Tyr Ser Glu  Ser Asp Asp Asp Trp  Cys 
    2495                 2500                 2505     


<210> 235
<211> 1980
<212> PRT
<213> Homo sapiens

<400> 235
Met Ala Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe Lys Pro 
1               5                   10                  15      


Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala Glu Ser 
            20                  25                  30          


Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu Asp Asp 
        35                  40                  45              


Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser 
    50                  55                  60                  


Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala Val Pro 
65                  70                  75                  80  


Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe Val Val 
                85                  90                  95      


Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro Ala Leu 
            100                 105                 110         


Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile Lys Ile 
        115                 120                 125             


Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile Leu Thr 
    130                 135                 140                 


Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Asp Trp Ser Lys Asn 
145                 150                 155                 160 


Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys 
                165                 170                 175     


Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu Arg Asp 
            180                 185                 190         


Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Ile Thr 
        195                 200                 205             


Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val 
    210                 215                 220                 


Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile 
225                 230                 235                 240 


Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile 
                245                 250                 255     


Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu 
            260                 265                 270         


Phe Met Gly Asn Leu Arg Asn Lys Cys Val Val Trp Pro Ile Asn Phe 
        275                 280                 285             


Asn Glu Ser Tyr Leu Glu Asn Gly Thr Lys Gly Phe Asp Trp Glu Glu 
    290                 295                 300                 


Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Thr Val Pro Gly Met Leu Glu 
305                 310                 315                 320 


Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly 
                325                 330                 335     


Tyr Gln Cys Met Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser 
            340                 345                 350         


Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr 
        355                 360                 365             


Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly 
    370                 375                 380                 


Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser Phe 
385                 390                 395                 400 


Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu 
                405                 410                 415     


Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe 
            420                 425                 430         


Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile Glu 
    450                 455                 460                 


Glu Glu Gly Glu Glu Gly Gly Gly Ser Pro Arg Ser Ser Ser Glu Ile 
465                 470                 475                 480 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
                485                 490                 495     


Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp Pro 
            500                 505                 510         


Glu Lys Val Phe Lys Ser Glu Ser Glu Asp Gly Met Arg Arg Lys Ala 
        515                 520                 525             


Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met Asn 
    530                 535                 540                 


Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His Asn 
545                 550                 555                 560 


Ser Lys Ser Ser Ile Phe Ser Phe Arg Gly Pro Gly Arg Phe Arg Asp 
                565                 570                 575     


Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 
            580                 585                 590         


Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 
        595                 600                 605             


Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Gly Ser 
    610                 615                 620                 


Arg Ser Ser Arg Ile Phe Pro Ser Leu Arg Arg Ser Val Lys Arg Asn 
625                 630                 635                 640 


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Gly Pro Gly 
                645                 650                 655     


Ser His Ile Gly Gly Arg Leu Leu Pro Glu Ala Thr Thr Glu Val Glu 
            660                 665                 670         


Ile Lys Lys Lys Gly Pro Gly Ser Leu Leu Val Ser Met Asp Gln Leu 
        675                 680                 685             


Ala Ser Tyr Gly Arg Lys Asp Arg Ile Asn Ser Ile Met Ser Val Val 
    690                 695                 700                 


Thr Asn Thr Leu Val Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro 
705                 710                 715                 720 


Pro Cys Trp Tyr Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His 
                725                 730                 735     


Pro Tyr Trp Ile Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp 
            740                 745                 750         


Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu 
        755                 760                 765             


Phe Met Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val 
    770                 775                 780                 


Leu Ala Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met 
785                 790                 795                 800 


Phe Leu Lys Leu Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly 
                805                 810                 815     


Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu 
            820                 825                 830         


Ser Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu 
        835                 840                 845             


Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu 
    850                 855                 860                 


Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu 
865                 870                 875                 880 


Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu 
                885                 890                 895     


Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Asp Cys 
            900                 905                 910         


Glu Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile 
        915                 920                 925             


Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys 
    930                 935                 940                 


Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val 
945                 950                 955                 960 


Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu 
                965                 970                 975     


Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly 
            980                 985                 990         


Glu Met Asn Asn Leu Gln Ile Ser  Val Ile Arg Ile Lys  Lys Gly Val 
        995                 1000                 1005             


Ala Trp  Thr Lys Leu Lys Val  His Ala Phe Met Gln  Ala His Phe 
    1010                 1015                 1020             


Lys Gln  Arg Glu Ala Asp Glu  Val Lys Pro Leu Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Ala Asn Cys Ile  Ala Asn His Thr Gly  Ala Asp Ile 
    1040                 1045                 1050             


His Arg  Asn Gly Asp Phe Gln  Lys Asn Gly Asn Gly  Thr Thr Ser 
    1055                 1060                 1065             


Gly Ile  Gly Ser Ser Val Glu  Lys Tyr Ile Ile Asp  Glu Asp His 
    1070                 1075                 1080             


Met Ser  Phe Ile Asn Asn Pro  Asn Leu Thr Val Arg  Val Pro Ile 
    1085                 1090                 1095             


Ala Val  Gly Glu Ser Asp Phe  Glu Asn Leu Asn Thr  Glu Asp Val 
    1100                 1105                 1110             


Ser Ser  Glu Ser Asp Pro Glu  Gly Ser Lys Asp Lys  Leu Asp Asp 
    1115                 1120                 1125             


Thr Ser  Ser Ser Glu Gly Ser  Thr Ile Asp Ile Lys  Pro Glu Val 
    1130                 1135                 1140             


Glu Glu  Val Pro Val Glu Gln  Pro Glu Glu Tyr Leu  Asp Pro Asp 
    1145                 1150                 1155             


Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg Phe Lys  Cys Cys Gln 
    1160                 1165                 1170             


Val Asn  Ile Glu Glu Gly Leu  Gly Lys Ser Trp Trp  Ile Leu Arg 
    1175                 1180                 1185             


Lys Thr  Cys Phe Leu Ile Val  Glu His Asn Trp Phe  Glu Thr Phe 
    1190                 1195                 1200             


Ile Ile  Phe Met Ile Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu 
    1205                 1210                 1215             


Asp Ile  Tyr Ile Glu Gln Arg  Lys Thr Ile Arg Thr  Ile Leu Glu 
    1220                 1225                 1230             


Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu 
    1235                 1240                 1245             


Leu Lys  Trp Thr Ala Tyr Gly  Phe Val Lys Phe Phe  Thr Asn Ala 
    1250                 1255                 1260             


Trp Cys  Trp Leu Asp Phe Leu  Ile Val Ala Val Ser  Leu Val Ser 
    1265                 1270                 1275             


Leu Ile  Ala Asn Ala Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys 
    1280                 1285                 1290             


Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser 
    1295                 1300                 1305             


Arg Phe  Glu Gly Met Arg Val  Val Val Asn Ala Leu  Val Gly Ala 
    1310                 1315                 1320             


Ile Pro  Ser Ile Met Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp 
    1325                 1330                 1335             


Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu Phe Ala  Gly Lys Tyr 
    1340                 1345                 1350             


His Tyr  Cys Phe Asn Glu Thr  Ser Glu Ile Arg Phe  Glu Ile Glu 
    1355                 1360                 1365             


Asp Val  Asn Asn Lys Thr Glu  Cys Glu Lys Leu Met  Glu Gly Asn 
    1370                 1375                 1380             


Asn Thr  Glu Ile Arg Trp Lys  Asn Val Lys Ile Asn  Phe Asp Asn 
    1385                 1390                 1395             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1400                 1405                 1410             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Lys Pro 
    1415                 1420                 1425             


Asp Glu  Gln Pro Lys Tyr Glu  Asp Asn Ile Tyr Met  Tyr Ile Tyr 
    1430                 1435                 1440             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1445                 1450                 1455             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1460                 1465                 1470             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1475                 1480                 1485             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1490                 1495                 1500             


Ile Pro  Arg Pro Leu Asn Lys  Ile Gln Gly Ile Val  Phe Asp Phe 
    1505                 1510                 1515             


Val Thr  Gln Gln Ala Phe Asp  Ile Val Ile Met Met  Leu Ile Cys 
    1520                 1525                 1530             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Thr  Gln Ser Lys 
    1535                 1540                 1545             


Gln Met  Glu Asn Ile Leu Tyr  Trp Ile Asn Leu Val  Phe Val Ile 
    1550                 1555                 1560             


Phe Phe  Thr Cys Glu Cys Val  Leu Lys Met Phe Ala  Leu Arg His 
    1565                 1570                 1575             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1580                 1585                 1590             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Asp Ile  Ile Glu Lys 
    1595                 1600                 1605             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1610                 1615                 1620             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1625                 1630                 1635             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1640                 1645                 1650             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Phe  Ser Ile Phe 
    1655                 1660                 1665             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys His Glu Ala  Gly Ile Asp 
    1670                 1675                 1680             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1685                 1690                 1695             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Leu Pro 
    1700                 1705                 1710             


Ile Leu  Asn Arg Pro Pro Asp  Cys Ser Leu Asp Lys  Glu His Pro 
    1715                 1720                 1725             


Gly Ser  Gly Phe Lys Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile 
    1730                 1735                 1740             


Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser Phe Leu  Ile Val Val 
    1745                 1750                 1755             


Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn Phe Ser  Val Ala Thr 
    1760                 1765                 1770             


Glu Glu  Ser Ala Asp Pro Leu  Ser Glu Asp Asp Phe  Glu Thr Phe 
    1775                 1780                 1785             


Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile 
    1790                 1795                 1800             


Glu Tyr  Cys Lys Leu Ala Asp  Phe Ala Asp Ala Leu  Glu His Pro 
    1805                 1810                 1815             


Leu Arg  Val Pro Lys Pro Asn  Thr Ile Glu Leu Ile  Ala Met Asp 
    1820                 1825                 1830             


Leu Pro  Met Val Ser Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu 
    1835                 1840                 1845             


Phe Ala  Phe Thr Lys Arg Val  Leu Gly Asp Ser Gly  Glu Leu Asp 
    1850                 1855                 1860             


Ile Leu  Arg Gln Gln Met Glu  Glu Arg Phe Val Ala  Ser Asn Pro 
    1865                 1870                 1875             


Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr Thr Leu  Arg Arg Lys 
    1880                 1885                 1890             


Gln Glu  Glu Val Ser Ala Val  Val Leu Gln Arg Ala  Tyr Arg Gly 
    1895                 1900                 1905             


His Leu  Ala Arg Arg Gly Phe  Ile Cys Lys Lys Thr  Thr Ser Asn 
    1910                 1915                 1920             


Lys Leu  Glu Asn Gly Gly Thr  His Arg Glu Lys Lys  Glu Ser Thr 
    1925                 1930                 1935             


Pro Ser  Thr Ala Ser Leu Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Glu Lys  Glu Lys Gln Gln Arg  Ala Glu Glu Gly Arg  Arg Glu Arg 
    1955                 1960                 1965             


Ala Lys  Arg Gln Lys Glu Val  Arg Glu Ser Lys Cys  
    1970                 1975                 1980 


<210> 236
<211> 1464
<212> PRT
<213> Homo sapiens

<400> 236
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val 
    1460                 


<210> 237
<211> 599
<212> PRT
<213> Homo sapiens

<400> 237
Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu 
1               5                   10                  15      


Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val 
            20                  25                  30          


Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys 
        35                  40                  45              


Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu 
    50                  55                  60                  


Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly 
65                  70                  75                  80  


Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro 
                85                  90                  95      


Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly 
            100                 105                 110         


Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala 
        115                 120                 125             


Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile 
    130                 135                 140                 


Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro 
145                 150                 155                 160 


Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn 
                165                 170                 175     


Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe 
            180                 185                 190         


Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly 
        195                 200                 205             


Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu 
    210                 215                 220                 


Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val 
225                 230                 235                 240 


Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe 
                245                 250                 255     


Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile 
            260                 265                 270         


Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala 
        275                 280                 285             


Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile 
    290                 295                 300                 


Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser 
305                 310                 315                 320 


Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe 
                325                 330                 335     


Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser 
            340                 345                 350         


Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr 
        355                 360                 365             


Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu 
    370                 375                 380                 


Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr 
385                 390                 395                 400 


Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu 
                405                 410                 415     


Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr 
            420                 425                 430         


Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys 
        435                 440                 445             


Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val 
    450                 455                 460                 


Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe 
465                 470                 475                 480 


Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp 
                485                 490                 495     


Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe 
            500                 505                 510         


Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val 
        515                 520                 525             


Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser 
    530                 535                 540                 


Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys 
545                 550                 555                 560 


Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp 
                565                 570                 575     


Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser 
            580                 585                 590         


Thr Ser Lys Glu Ala Tyr Ile 
        595                 


<210> 238
<211> 1020
<212> PRT
<213> Homo sapiens

<400> 238
Met Gly Arg Gly Ala Gly Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala 
1               5                   10                  15      


Glu Asn Gly Gly Gly Lys Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu 
            20                  25                  30          


Leu Lys Lys Glu Val Ala Met Asp Asp His Lys Leu Ser Leu Asp Glu 
        35                  40                  45              


Leu Gly Arg Lys Tyr Gln Val Asp Leu Ser Lys Gly Leu Thr Asn Gln 
    50                  55                  60                  


Arg Ala Gln Asp Val Leu Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro 
65                  70                  75                  80  


Pro Pro Thr Thr Pro Glu Trp Val Lys Phe Cys Arg Gln Leu Phe Gly 
                85                  90                  95      


Gly Phe Ser Ile Leu Leu Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala 
            100                 105                 110         


Tyr Gly Ile Gln Ala Ala Met Glu Asp Glu Pro Ser Asn Asp Asn Leu 
        115                 120                 125             


Tyr Leu Gly Val Val Leu Ala Ala Val Val Ile Val Thr Gly Cys Phe 
    130                 135                 140                 


Ser Tyr Tyr Gln Glu Ala Lys Ser Ser Lys Ile Met Asp Ser Phe Lys 
145                 150                 155                 160 


Asn Met Val Pro Gln Gln Ala Leu Val Ile Arg Glu Gly Glu Lys Met 
                165                 170                 175     


Gln Ile Asn Ala Glu Glu Val Val Val Gly Asp Leu Val Glu Val Lys 
            180                 185                 190         


Gly Gly Asp Arg Val Pro Ala Asp Leu Arg Ile Ile Ser Ser His Gly 
        195                 200                 205             


Cys Lys Val Asp Asn Ser Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr 
    210                 215                 220                 


Arg Ser Pro Glu Phe Thr His Glu Asn Pro Leu Glu Thr Arg Asn Ile 
225                 230                 235                 240 


Cys Phe Phe Ser Thr Asn Cys Val Glu Gly Thr Ala Arg Gly Ile Val 
                245                 250                 255     


Ile Ala Thr Gly Asp Arg Thr Val Met Gly Arg Ile Ala Thr Leu Ala 
            260                 265                 270         


Ser Gly Leu Glu Val Gly Arg Thr Pro Ile Ala Met Glu Ile Glu His 
        275                 280                 285             


Phe Ile Gln Leu Ile Thr Gly Val Ala Val Phe Leu Gly Val Ser Phe 
    290                 295                 300                 


Phe Val Leu Ser Leu Ile Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile 
305                 310                 315                 320 


Phe Leu Ile Gly Ile Ile Val Ala Asn Val Pro Glu Gly Leu Leu Ala 
                325                 330                 335     


Thr Val Thr Val Cys Leu Thr Leu Thr Ala Lys Arg Met Ala Arg Lys 
            340                 345                 350         


Asn Cys Leu Val Lys Asn Leu Glu Ala Val Glu Thr Leu Gly Ser Thr 
        355                 360                 365             


Ser Thr Ile Cys Ser Asp Lys Thr Gly Thr Leu Thr Gln Asn Arg Met 
    370                 375                 380                 


Thr Val Ala His Met Trp Phe Asp Asn Gln Ile His Glu Ala Asp Thr 
385                 390                 395                 400 


Thr Glu Asp Gln Ser Gly Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp 
                405                 410                 415     


Thr Ala Leu Ser Arg Ile Ala Gly Leu Cys Asn Arg Ala Val Phe Lys 
            420                 425                 430         


Ala Gly Gln Glu Asn Ile Ser Val Ser Lys Arg Asp Thr Ala Gly Asp 
        435                 440                 445             


Ala Ser Glu Ser Ala Leu Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser 
    450                 455                 460                 


Val Arg Lys Met Arg Asp Arg Asn Pro Lys Val Ala Glu Ile Pro Phe 
465                 470                 475                 480 


Asn Ser Thr Asn Lys Tyr Gln Leu Ser Ile His Glu Arg Glu Asp Ser 
                485                 490                 495     


Pro Gln Ser His Val Leu Val Met Lys Gly Ala Pro Glu Arg Ile Leu 
            500                 505                 510         


Asp Arg Cys Ser Thr Ile Leu Val Gln Gly Lys Glu Ile Pro Leu Asp 
        515                 520                 525             


Lys Glu Met Gln Asp Ala Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly 
    530                 535                 540                 


Leu Gly Glu Arg Val Leu Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly 
545                 550                 555                 560 


Lys Phe Pro Arg Gly Phe Lys Phe Asp Thr Asp Glu Leu Asn Phe Pro 
                565                 570                 575     


Thr Glu Lys Leu Cys Phe Val Gly Leu Met Ser Met Ile Asp Pro Pro 
            580                 585                 590         


Arg Ala Ala Val Pro Asp Ala Val Gly Lys Cys Arg Ser Ala Gly Ile 
        595                 600                 605             


Lys Val Ile Met Val Thr Gly Asp His Pro Ile Thr Ala Lys Ala Ile 
    610                 615                 620                 


Ala Lys Gly Val Gly Ile Ile Ser Glu Gly Asn Glu Thr Val Glu Asp 
625                 630                 635                 640 


Ile Ala Ala Arg Leu Asn Ile Pro Met Ser Gln Val Asn Pro Arg Glu 
                645                 650                 655     


Ala Lys Ala Cys Val Val His Gly Ser Asp Leu Lys Asp Met Thr Ser 
            660                 665                 670         


Glu Gln Leu Asp Glu Ile Leu Lys Asn His Thr Glu Ile Val Phe Ala 
        675                 680                 685             


Arg Thr Ser Pro Gln Gln Lys Leu Ile Ile Val Glu Gly Cys Gln Arg 
    690                 695                 700                 


Gln Gly Ala Ile Val Ala Val Thr Gly Asp Gly Val Asn Asp Ser Pro 
705                 710                 715                 720 


Ala Leu Lys Lys Ala Asp Ile Gly Ile Ala Met Gly Ile Ser Gly Ser 
                725                 730                 735     


Asp Val Ser Lys Gln Ala Ala Asp Met Ile Leu Leu Asp Asp Asn Phe 
            740                 745                 750         


Ala Ser Ile Val Thr Gly Val Glu Glu Gly Arg Leu Ile Phe Asp Asn 
        755                 760                 765             


Leu Lys Lys Ser Ile Ala Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile 
    770                 775                 780                 


Thr Pro Phe Leu Leu Phe Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly 
785                 790                 795                 800 


Thr Val Thr Ile Leu Cys Ile Asp Leu Gly Thr Asp Met Val Pro Ala 
                805                 810                 815     


Ile Ser Leu Ala Tyr Glu Ala Ala Glu Ser Asp Ile Met Lys Arg Gln 
            820                 825                 830         


Pro Arg Asn Ser Gln Thr Asp Lys Leu Val Asn Glu Arg Leu Ile Ser 
        835                 840                 845             


Met Ala Tyr Gly Gln Ile Gly Met Ile Gln Ala Leu Gly Gly Phe Phe 
    850                 855                 860                 


Thr Tyr Phe Val Ile Leu Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu 
865                 870                 875                 880 


Leu Gly Ile Arg Leu Asp Trp Asp Asp Arg Thr Met Asn Asp Leu Glu 
                885                 890                 895     


Asp Ser Tyr Gly Gln Glu Trp Thr Tyr Glu Gln Arg Lys Val Val Glu 
            900                 905                 910         


Phe Thr Cys His Thr Ala Phe Phe Ala Ser Ile Val Val Val Gln Trp 
        915                 920                 925             


Ala Asp Leu Ile Ile Cys Lys Thr Arg Arg Asn Ser Val Phe Gln Gln 
    930                 935                 940                 


Gly Met Lys Asn Lys Ile Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala 
945                 950                 955                 960 


Leu Ala Ala Phe Leu Ser Tyr Cys Pro Gly Met Gly Val Ala Leu Arg 
                965                 970                 975     


Met Tyr Pro Leu Lys Val Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser 
            980                 985                 990         


Leu Leu Ile Phe Ile Tyr Asp Glu  Val Arg Lys Leu Ile  Leu Arg Arg 
        995                 1000                 1005             


Tyr Pro  Gly Gly Trp Val Glu  Lys Glu Thr Tyr Tyr  
    1010                 1015                 1020 


<210> 239
<211> 1013
<212> PRT
<213> Homo sapiens

<400> 239
Met Gly Asp Lys Lys Asp Asp Lys Asp Ser Pro Lys Lys Asn Lys Gly 
1               5                   10                  15      


Lys Glu Arg Arg Asp Leu Asp Asp Leu Lys Lys Glu Val Ala Met Thr 
            20                  25                  30          


Glu His Lys Met Ser Val Glu Glu Val Cys Arg Lys Tyr Asn Thr Asp 
        35                  40                  45              


Cys Val Gln Gly Leu Thr His Ser Lys Ala Gln Glu Ile Leu Ala Arg 
    50                  55                  60                  


Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu Trp Val 
65                  70                  75                  80  


Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu Trp Ile 
                85                  90                  95      


Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Gly Thr Glu 
            100                 105                 110         


Asp Asp Pro Ser Gly Asp Asn Leu Tyr Leu Gly Ile Val Leu Ala Ala 
        115                 120                 125             


Val Val Ile Ile Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala Lys Ser 
    130                 135                 140                 


Ser Lys Ile Met Glu Ser Phe Lys Asn Met Val Pro Gln Gln Ala Leu 
145                 150                 155                 160 


Val Ile Arg Glu Gly Glu Lys Met Gln Val Asn Ala Glu Glu Val Val 
                165                 170                 175     


Val Gly Asp Leu Val Glu Ile Lys Gly Gly Asp Arg Val Pro Ala Asp 
            180                 185                 190         


Leu Arg Ile Ile Ser Ala His Gly Cys Lys Val Asp Asn Ser Ser Leu 
        195                 200                 205             


Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Asp Cys Thr His Asp 
    210                 215                 220                 


Asn Pro Leu Glu Thr Arg Asn Ile Thr Phe Phe Ser Thr Asn Cys Val 
225                 230                 235                 240 


Glu Gly Thr Ala Arg Gly Val Val Val Ala Thr Gly Asp Arg Thr Val 
                245                 250                 255     


Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly Lys Thr 
            260                 265                 270         


Pro Ile Ala Ile Glu Ile Glu His Phe Ile Gln Leu Ile Thr Gly Val 
        275                 280                 285             


Ala Val Phe Leu Gly Val Ser Phe Phe Ile Leu Ser Leu Ile Leu Gly 
    290                 295                 300                 


Tyr Thr Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile Val Ala 
305                 310                 315                 320 


Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu Thr Leu 
                325                 330                 335     


Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn Leu Glu 
            340                 345                 350         


Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp Lys Thr 
        355                 360                 365             


Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp Phe Asp 
    370                 375                 380                 


Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly Thr Ser 
385                 390                 395                 400 


Phe Asp Lys Ser Ser His Thr Trp Val Ala Leu Ser His Ile Ala Gly 
                405                 410                 415     


Leu Cys Asn Arg Ala Val Phe Lys Gly Gly Gln Asp Asn Ile Pro Val 
            420                 425                 430         


Leu Lys Arg Asp Val Ala Gly Asp Ala Ser Glu Ser Ala Leu Leu Lys 
        435                 440                 445             


Cys Ile Glu Leu Ser Ser Gly Ser Val Lys Leu Met Arg Glu Arg Asn 
    450                 455                 460                 


Lys Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr Gln Leu 
465                 470                 475                 480 


Ser Ile His Glu Thr Glu Asp Pro Asn Asp Asn Arg Tyr Leu Leu Val 
                485                 490                 495     


Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile Leu 
            500                 505                 510         


Leu Gln Gly Lys Glu Gln Pro Leu Asp Glu Glu Met Lys Glu Ala Phe 
        515                 520                 525             


Gln Asn Ala Tyr Leu Glu Leu Gly Gly Leu Gly Glu Arg Val Leu Gly 
    530                 535                 540                 


Phe Cys His Tyr Tyr Leu Pro Glu Glu Gln Phe Pro Lys Gly Phe Ala 
545                 550                 555                 560 


Phe Asp Cys Asp Asp Val Asn Phe Thr Thr Asp Asn Leu Cys Phe Val 
                565                 570                 575     


Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp Ala 
            580                 585                 590         


Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr Gly 
        595                 600                 605             


Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile Ile 
    610                 615                 620                 


Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn Ile 
625                 630                 635                 640 


Pro Val Ser Gln Val Asn Pro Arg Asp Ala Lys Ala Cys Val Ile His 
                645                 650                 655     


Gly Thr Asp Leu Lys Asp Phe Thr Ser Glu Gln Ile Asp Glu Ile Leu 
            660                 665                 670         


Gln Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln Lys 
        675                 680                 685             


Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala Val 
    690                 695                 700                 


Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp Ile 
705                 710                 715                 720 


Gly Val Ala Met Gly Ile Ala Gly Ser Asp Val Ser Lys Gln Ala Ala 
                725                 730                 735     


Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly Val 
            740                 745                 750         


Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala Tyr 
        755                 760                 765             


Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe Ile 
    770                 775                 780                 


Met Ala Asn Ile Pro Leu Pro Leu Gly Thr Ile Thr Ile Leu Cys Ile 
785                 790                 795                 800 


Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu Ala 
                805                 810                 815     


Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Pro Arg Thr Asp 
            820                 825                 830         


Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile Gly 
        835                 840                 845             


Met Ile Gln Ala Leu Gly Gly Phe Phe Ser Tyr Phe Val Ile Leu Ala 
    850                 855                 860                 


Glu Asn Gly Phe Leu Pro Gly Asn Leu Val Gly Ile Arg Leu Asn Trp 
865                 870                 875                 880 


Asp Asp Arg Thr Val Asn Asp Leu Glu Asp Ser Tyr Gly Gln Gln Trp 
                885                 890                 895     


Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala Phe 
            900                 905                 910         


Phe Val Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys Lys 
        915                 920                 925             


Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile Leu 
    930                 935                 940                 


Ile Phe Gly Leu Phe Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser Tyr 
945                 950                 955                 960 


Cys Pro Gly Met Asp Val Ala Leu Arg Met Tyr Pro Leu Lys Pro Ser 
                965                 970                 975     


Trp Trp Phe Cys Ala Phe Pro Tyr Ser Phe Leu Ile Phe Val Tyr Asp 
            980                 985                 990         


Glu Ile Arg Lys Leu Ile Leu Arg  Arg Asn Pro Gly Gly  Trp Val Glu 
        995                 1000                 1005             


Lys Glu  Thr Tyr Tyr 
    1010             


<210> 240
<211> 1988
<212> PRT
<213> Homo sapiens

<400> 240
Met Ala Met Leu Pro Pro Pro Gly Pro Gln Ser Phe Val His Phe Thr 
1               5                   10                  15      


Lys Gln Ser Leu Ala Leu Ile Glu Gln Arg Ile Ala Glu Arg Lys Ser 
            20                  25                  30          


Lys Glu Pro Lys Glu Glu Lys Lys Asp Asp Asp Glu Glu Ala Pro Lys 
        35                  40                  45              


Pro Ser Ser Asp Leu Glu Ala Gly Lys Gln Leu Pro Phe Ile Tyr Gly 
    50                  55                  60                  


Asp Ile Pro Pro Gly Met Val Ser Glu Pro Leu Glu Asp Leu Asp Pro 
65                  70                  75                  80  


Tyr Tyr Ala Asp Lys Lys Thr Phe Ile Val Leu Asn Lys Gly Lys Thr 
                85                  90                  95      


Ile Phe Arg Phe Asn Ala Thr Pro Ala Leu Tyr Met Leu Ser Pro Phe 
            100                 105                 110         


Ser Pro Leu Arg Arg Ile Ser Ile Lys Ile Leu Val His Ser Leu Phe 
        115                 120                 125             


Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Ile Phe Met Thr 
    130                 135                 140                 


Met Asn Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr Phe Thr 
145                 150                 155                 160 


Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys Ile Leu Ala Arg Gly Phe 
                165                 170                 175     


Cys Val Gly Glu Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp Leu Asp 
            180                 185                 190         


Phe Val Val Ile Val Phe Ala Tyr Leu Thr Glu Phe Val Asn Leu Gly 
        195                 200                 205             


Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu Lys Thr 
    210                 215                 220                 


Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu Ile Gln 
225                 230                 235                 240 


Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe Cys Leu 
                245                 250                 255     


Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn Leu Lys 
            260                 265                 270         


His Lys Cys Phe Arg Asn Ser Leu Glu Asn Asn Glu Thr Leu Glu Ser 
        275                 280                 285             


Ile Met Asn Thr Leu Glu Ser Glu Glu Asp Phe Arg Lys Tyr Phe Tyr 
    290                 295                 300                 


Tyr Leu Glu Gly Ser Lys Asp Ala Leu Leu Cys Gly Phe Ser Thr Asp 
305                 310                 315                 320 


Ser Gly Gln Cys Pro Glu Gly Tyr Thr Cys Val Lys Ile Gly Arg Asn 
                325                 330                 335     


Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr Phe Ser Trp Ala Phe Leu 
            340                 345                 350         


Ala Leu Phe Arg Leu Met Thr Gln Asp Tyr Trp Glu Asn Leu Tyr Gln 
        355                 360                 365             


Gln Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met Ile Phe Phe Val Val 
    370                 375                 380                 


Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn Leu Ile Leu Ala Val 
385                 390                 395                 400 


Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala Asn Ile Glu Glu Ala 
                405                 410                 415     


Lys Gln Lys Glu Leu Glu Phe Gln Gln Met Leu Asp Arg Leu Lys Lys 
            420                 425                 430         


Glu Gln Glu Glu Ala Glu Ala Ile Ala Ala Ala Ala Ala Glu Tyr Thr 
        435                 440                 445             


Ser Ile Arg Arg Ser Arg Ile Met Gly Leu Ser Glu Ser Ser Ser Glu 
    450                 455                 460                 


Thr Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg 
465                 470                 475                 480 


Lys Lys Lys Asn Gln Lys Lys Leu Ser Ser Gly Glu Glu Lys Gly Asp 
                485                 490                 495     


Ala Glu Lys Leu Ser Lys Ser Glu Ser Glu Asp Ser Ile Arg Arg Lys 
            500                 505                 510         


Ser Phe His Leu Gly Val Glu Gly His Arg Arg Ala His Glu Lys Arg 
        515                 520                 525             


Leu Ser Thr Pro Asn Gln Ser Pro Leu Ser Ile Arg Gly Ser Leu Phe 
    530                 535                 540                 


Ser Ala Arg Arg Ser Ser Arg Thr Ser Leu Phe Ser Phe Lys Gly Arg 
545                 550                 555                 560 


Gly Arg Asp Ile Gly Ser Glu Thr Glu Phe Ala Asp Asp Glu His Ser 
                565                 570                 575     


Ile Phe Gly Asp Asn Glu Ser Arg Arg Gly Ser Leu Phe Val Pro His 
            580                 585                 590         


Arg Pro Gln Glu Arg Arg Ser Ser Asn Ile Ser Gln Ala Ser Arg Ser 
        595                 600                 605             


Pro Pro Met Leu Pro Val Asn Gly Lys Met His Ser Ala Val Asp Cys 
    610                 615                 620                 


Asn Gly Val Val Ser Leu Val Asp Gly Arg Ser Ala Leu Met Leu Pro 
625                 630                 635                 640 


Asn Gly Gln Leu Leu Pro Glu Val Ile Ile Asp Lys Ala Thr Ser Asp 
                645                 650                 655     


Asp Ser Gly Thr Thr Asn Gln Ile His Lys Lys Arg Arg Cys Ser Ser 
            660                 665                 670         


Tyr Leu Leu Ser Glu Asp Met Leu Asn Asp Pro Asn Leu Arg Gln Arg 
        675                 680                 685             


Ala Met Ser Arg Ala Ser Ile Leu Thr Asn Thr Val Glu Glu Leu Glu 
    690                 695                 700                 


Glu Ser Arg Gln Lys Cys Pro Pro Trp Trp Tyr Arg Phe Ala His Lys 
705                 710                 715                 720 


Phe Leu Ile Trp Asn Cys Ser Pro Tyr Trp Ile Lys Phe Lys Lys Cys 
                725                 730                 735     


Ile Tyr Phe Ile Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile 
            740                 745                 750         


Cys Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His His Pro Met 
        755                 760                 765             


Thr Glu Glu Phe Lys Asn Val Leu Ala Ile Gly Asn Leu Val Phe Thr 
    770                 775                 780                 


Gly Ile Phe Ala Ala Glu Met Val Leu Lys Leu Ile Ala Met Asp Pro 
785                 790                 795                 800 


Tyr Glu Tyr Phe Gln Val Gly Trp Asn Ile Phe Asp Ser Leu Ile Val 
                805                 810                 815     


Thr Leu Ser Leu Val Glu Leu Phe Leu Ala Asp Val Glu Gly Leu Ser 
            820                 825                 830         


Val Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser 
        835                 840                 845             


Trp Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly 
    850                 855                 860                 


Ala Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe 
865                 870                 875                 880 


Ala Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val 
                885                 890                 895     


Cys Lys Ile Asn Asp Asp Cys Thr Leu Pro Arg Trp His Met Asn Asp 
            900                 905                 910         


Phe Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp 
        915                 920                 925             


Ile Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Ala Met Cys 
    930                 935                 940                 


Leu Ile Val Tyr Met Met Val Met Val Ile Gly Asn Leu Val Val Leu 
945                 950                 955                 960 


Asn Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu 
                965                 970                 975     


Thr Ala Ile Glu Glu Asp Pro Asp Ala Asn Asn Leu Gln Ile Ala Val 
            980                 985                 990         


Thr Arg Ile Lys Lys Gly Ile Asn  Tyr Val Lys Gln Thr  Leu Arg Glu 
        995                 1000                 1005             


Phe Ile  Leu Lys Ala Phe Ser  Lys Lys Pro Lys Ile  Ser Arg Glu 
    1010                 1015                 1020             


Ile Arg  Gln Ala Glu Asp Leu  Asn Thr Lys Lys Glu  Asn Tyr Ile 
    1025                 1030                 1035             


Ser Asn  His Thr Leu Ala Glu  Met Ser Lys Gly His  Asn Phe Leu 
    1040                 1045                 1050             


Lys Glu  Lys Asp Lys Ile Ser  Gly Phe Gly Ser Ser  Val Asp Lys 
    1055                 1060                 1065             


His Leu  Met Glu Asp Ser Asp  Gly Gln Ser Phe Ile  His Asn Pro 
    1070                 1075                 1080             


Ser Leu  Thr Val Thr Val Pro  Ile Ala Pro Gly Glu  Ser Asp Leu 
    1085                 1090                 1095             


Glu Asn  Met Asn Ala Glu Glu  Leu Ser Ser Asp Ser  Asp Ser Glu 
    1100                 1105                 1110             


Tyr Ser  Lys Val Arg Leu Asn  Arg Ser Ser Ser Ser  Glu Cys Ser 
    1115                 1120                 1125             


Thr Val  Asp Asn Pro Leu Pro  Gly Glu Gly Glu Glu  Ala Glu Ala 
    1130                 1135                 1140             


Glu Pro  Met Asn Ser Asp Glu  Pro Glu Ala Cys Phe  Thr Asp Gly 
    1145                 1150                 1155             


Cys Val  Trp Arg Phe Ser Cys  Cys Gln Val Asn Ile  Glu Ser Gly 
    1160                 1165                 1170             


Lys Gly  Lys Ile Trp Trp Asn  Ile Arg Lys Thr Cys  Tyr Lys Ile 
    1175                 1180                 1185             


Val Glu  His Ser Trp Phe Glu  Ser Phe Ile Val Leu  Met Ile Leu 
    1190                 1195                 1200             


Leu Ser  Ser Gly Ala Leu Ala  Phe Glu Asp Ile Tyr  Ile Glu Arg 
    1205                 1210                 1215             


Lys Lys  Thr Ile Lys Ile Ile  Leu Glu Tyr Ala Asp  Lys Ile Phe 
    1220                 1225                 1230             


Thr Tyr  Ile Phe Ile Leu Glu  Met Leu Leu Lys Trp  Ile Ala Tyr 
    1235                 1240                 1245             


Gly Tyr  Lys Thr Tyr Phe Thr  Asn Ala Trp Cys Trp  Leu Asp Phe 
    1250                 1255                 1260             


Leu Ile  Val Asp Val Ser Leu  Val Thr Leu Val Ala  Asn Thr Leu 
    1265                 1270                 1275             


Gly Tyr  Ser Asp Leu Gly Pro  Ile Lys Ser Leu Arg  Thr Leu Arg 
    1280                 1285                 1290             


Ala Leu  Arg Pro Leu Arg Ala  Leu Ser Arg Phe Glu  Gly Met Arg 
    1295                 1300                 1305             


Val Val  Val Asn Ala Leu Ile  Gly Ala Ile Pro Ser  Ile Met Asn 
    1310                 1315                 1320             


Val Leu  Leu Val Cys Leu Ile  Phe Trp Leu Ile Phe  Ser Ile Met 
    1325                 1330                 1335             


Gly Val  Asn Leu Phe Ala Gly  Lys Phe Tyr Glu Cys  Ile Asn Thr 
    1340                 1345                 1350             


Thr Asp  Gly Ser Arg Phe Pro  Ala Ser Gln Val Pro  Asn Arg Ser 
    1355                 1360                 1365             


Glu Cys  Phe Ala Leu Met Asn  Val Ser Gln Asn Val  Arg Trp Lys 
    1370                 1375                 1380             


Asn Leu  Lys Val Asn Phe Asp  Asn Val Gly Leu Gly  Tyr Leu Ser 
    1385                 1390                 1395             


Leu Leu  Gln Val Ala Thr Phe  Lys Gly Trp Thr Ile  Ile Met Tyr 
    1400                 1405                 1410             


Ala Ala  Val Asp Ser Val Asn  Val Asp Lys Gln Pro  Lys Tyr Glu 
    1415                 1420                 1425             


Tyr Ser  Leu Tyr Met Tyr Ile  Tyr Phe Val Val Phe  Ile Ile Phe 
    1430                 1435                 1440             


Gly Ser  Phe Phe Thr Leu Asn  Leu Phe Ile Gly Val  Ile Ile Asp 
    1445                 1450                 1455             


Asn Phe  Asn Gln Gln Lys Lys  Lys Leu Gly Gly Gln  Asp Ile Phe 
    1460                 1465                 1470             


Met Thr  Glu Glu Gln Lys Lys  Tyr Tyr Asn Ala Met  Lys Lys Leu 
    1475                 1480                 1485             


Gly Ser  Lys Lys Pro Gln Lys  Pro Ile Pro Arg Pro  Gly Asn Lys 
    1490                 1495                 1500             


Ile Gln  Gly Cys Ile Phe Asp  Leu Val Thr Asn Gln  Ala Phe Asp 
    1505                 1510                 1515             


Ile Ser  Ile Met Val Leu Ile  Cys Leu Asn Met Val  Thr Met Met 
    1520                 1525                 1530             


Val Glu  Lys Glu Gly Gln Ser  Gln His Met Thr Glu  Val Leu Tyr 
    1535                 1540                 1545             


Trp Ile  Asn Val Val Phe Ile  Ile Leu Phe Thr Gly  Glu Cys Val 
    1550                 1555                 1560             


Leu Lys  Leu Ile Ser Leu Arg  His Tyr Tyr Phe Thr  Val Gly Trp 
    1565                 1570                 1575             


Asn Ile  Phe Asp Phe Val Val  Val Ile Ile Ser Ile  Val Gly Met 
    1580                 1585                 1590             


Phe Leu  Ala Asp Leu Ile Glu  Thr Tyr Phe Val Ser  Pro Thr Leu 
    1595                 1600                 1605             


Phe Arg  Val Ile Arg Leu Ala  Arg Ile Gly Arg Ile  Leu Arg Leu 
    1610                 1615                 1620             


Val Lys  Gly Ala Lys Gly Ile  Arg Thr Leu Leu Phe  Ala Leu Met 
    1625                 1630                 1635             


Met Ser  Leu Pro Ala Leu Phe  Asn Ile Gly Leu Leu  Leu Phe Leu 
    1640                 1645                 1650             


Val Met  Phe Ile Tyr Ala Ile  Phe Gly Met Ser Asn  Phe Ala Tyr 
    1655                 1660                 1665             


Val Lys  Lys Glu Asp Gly Ile  Asn Asp Met Phe Asn  Phe Glu Thr 
    1670                 1675                 1680             


Phe Gly  Asn Ser Met Ile Cys  Leu Phe Gln Ile Thr  Thr Ser Ala 
    1685                 1690                 1695             


Gly Trp  Asp Gly Leu Leu Ala  Pro Ile Leu Asn Ser  Lys Pro Pro 
    1700                 1705                 1710             


Asp Cys  Asp Pro Lys Lys Val  His Pro Gly Ser Ser  Val Glu Gly 
    1715                 1720                 1725             


Asp Cys  Gly Asn Pro Ser Val  Gly Ile Phe Tyr Phe  Val Ser Tyr 
    1730                 1735                 1740             


Ile Ile  Ile Ser Phe Leu Val  Val Val Asn Met Tyr  Ile Ala Val 
    1745                 1750                 1755             


Ile Leu  Glu Asn Phe Ser Val  Ala Thr Glu Glu Ser  Thr Glu Pro 
    1760                 1765                 1770             


Leu Ser  Glu Asp Asp Phe Glu  Met Phe Tyr Glu Val  Trp Glu Lys 
    1775                 1780                 1785             


Phe Asp  Pro Asp Ala Thr Gln  Phe Ile Glu Phe Ser  Lys Leu Ser 
    1790                 1795                 1800             


Asp Phe  Ala Ala Ala Leu Asp  Pro Pro Leu Leu Ile  Ala Lys Pro 
    1805                 1810                 1815             


Asn Lys  Val Gln Leu Ile Ala  Met Asp Leu Pro Met  Val Ser Gly 
    1820                 1825                 1830             


Asp Arg  Ile His Cys Leu Asp  Ile Leu Phe Ala Phe  Thr Lys Arg 
    1835                 1840                 1845             


Val Leu  Gly Glu Ser Gly Glu  Met Asp Ser Leu Arg  Ser Gln Met 
    1850                 1855                 1860             


Glu Glu  Arg Phe Met Ser Ala  Asn Pro Ser Lys Val  Ser Tyr Glu 
    1865                 1870                 1875             


Pro Ile  Thr Thr Thr Leu Lys  Arg Lys Gln Glu Asp  Val Ser Ala 
    1880                 1885                 1890             


Thr Val  Ile Gln Arg Ala Tyr  Arg Arg Tyr Arg Leu  Arg Gln Asn 
    1895                 1900                 1905             


Val Lys  Asn Ile Ser Ser Ile  Tyr Ile Lys Asp Gly  Asp Arg Asp 
    1910                 1915                 1920             


Asp Asp  Leu Leu Asn Lys Lys  Asp Met Ala Phe Asp  Asn Val Asn 
    1925                 1930                 1935             


Glu Asn  Ser Ser Pro Glu Lys  Thr Asp Ala Thr Ser  Ser Thr Thr 
    1940                 1945                 1950             


Ser Pro  Pro Ser Tyr Asp Ser  Val Thr Lys Pro Asp  Lys Glu Lys 
    1955                 1960                 1965             


Tyr Glu  Gln Asp Arg Thr Glu  Lys Glu Asp Lys Gly  Lys Asp Ser 
    1970                 1975                 1980             


Lys Glu  Ser Lys Lys 
    1985             


<210> 241
<211> 473
<212> PRT
<213> Homo sapiens

<400> 241
Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn 
465                 470             


<210> 242
<211> 872
<212> PRT
<213> Homo sapiens

<400> 242
Met Gly Leu Lys Ala Arg Arg Ala Ala Gly Ala Ala Gly Gly Gly Gly 
1               5                   10                  15      


Asp Gly Gly Gly Gly Gly Gly Gly Ala Ala Asn Pro Ala Gly Gly Asp 
            20                  25                  30          


Ala Ala Ala Ala Gly Asp Glu Glu Arg Lys Val Gly Leu Ala Pro Gly 
        35                  40                  45              


Asp Val Glu Gln Val Thr Leu Ala Leu Gly Ala Gly Ala Asp Lys Asp 
    50                  55                  60                  


Gly Thr Leu Leu Leu Glu Gly Gly Gly Arg Asp Glu Gly Gln Arg Arg 
65                  70                  75                  80  


Thr Pro Gln Gly Ile Gly Leu Leu Ala Lys Thr Pro Leu Ser Arg Pro 
                85                  90                  95      


Val Lys Arg Asn Asn Ala Lys Tyr Arg Arg Ile Gln Thr Leu Ile Tyr 
            100                 105                 110         


Asp Ala Leu Glu Arg Pro Arg Gly Trp Ala Leu Leu Tyr His Ala Leu 
        115                 120                 125             


Val Phe Leu Ile Val Leu Gly Cys Leu Ile Leu Ala Val Leu Thr Thr 
    130                 135                 140                 


Phe Lys Glu Tyr Glu Thr Val Ser Gly Asp Trp Leu Leu Leu Leu Glu 
145                 150                 155                 160 


Thr Phe Ala Ile Phe Ile Phe Gly Ala Glu Phe Ala Leu Arg Ile Trp 
                165                 170                 175     


Ala Ala Gly Cys Cys Cys Arg Tyr Lys Gly Trp Arg Gly Arg Leu Lys 
            180                 185                 190         


Phe Ala Arg Lys Pro Leu Cys Met Leu Asp Ile Phe Val Leu Ile Ala 
        195                 200                 205             


Ser Val Pro Val Val Ala Val Gly Asn Gln Gly Asn Val Leu Ala Thr 
    210                 215                 220                 


Ser Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met Leu Arg Met 
225                 230                 235                 240 


Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Ala Ile Cys Ala 
                245                 250                 255     


His Ser Lys Glu Leu Ile Thr Ala Trp Tyr Ile Gly Phe Leu Thr Leu 
            260                 265                 270         


Ile Leu Ser Ser Phe Leu Val Tyr Leu Val Glu Lys Asp Val Pro Glu 
        275                 280                 285             


Val Asp Ala Gln Gly Glu Glu Met Lys Glu Glu Phe Glu Thr Tyr Ala 
    290                 295                 300                 


Asp Ala Leu Trp Trp Gly Leu Ile Thr Leu Ala Thr Ile Gly Tyr Gly 
305                 310                 315                 320 


Asp Lys Thr Pro Lys Thr Trp Glu Gly Arg Leu Ile Ala Ala Thr Phe 
                325                 330                 335     


Ser Leu Ile Gly Val Ser Phe Phe Ala Leu Pro Ala Gly Ile Leu Gly 
            340                 345                 350         


Ser Gly Leu Ala Leu Lys Val Gln Glu Gln His Arg Gln Lys His Phe 
        355                 360                 365             


Glu Lys Arg Arg Lys Pro Ala Ala Glu Leu Ile Gln Ala Ala Trp Arg 
    370                 375                 380                 


Tyr Tyr Ala Thr Asn Pro Asn Arg Ile Asp Leu Val Ala Thr Trp Arg 
385                 390                 395                 400 


Phe Tyr Glu Ser Val Val Ser Phe Pro Phe Phe Arg Lys Glu Gln Leu 
                405                 410                 415     


Glu Ala Ala Ser Ser Gln Lys Leu Gly Leu Leu Asp Arg Val Arg Leu 
            420                 425                 430         


Ser Asn Pro Arg Gly Ser Asn Thr Lys Gly Lys Leu Phe Thr Pro Leu 
        435                 440                 445             


Asn Val Asp Ala Ile Glu Glu Ser Pro Ser Lys Glu Pro Lys Pro Val 
    450                 455                 460                 


Gly Leu Asn Asn Lys Glu Arg Phe Arg Thr Ala Phe Arg Met Lys Ala 
465                 470                 475                 480 


Tyr Ala Phe Trp Gln Ser Ser Glu Asp Ala Gly Thr Gly Asp Pro Met 
                485                 490                 495     


Ala Glu Asp Arg Gly Tyr Gly Asn Asp Phe Pro Ile Glu Asp Met Ile 
            500                 505                 510         


Pro Thr Leu Lys Ala Ala Ile Arg Ala Val Arg Ile Leu Gln Phe Arg 
        515                 520                 525             


Leu Tyr Lys Lys Lys Phe Lys Glu Thr Leu Arg Pro Tyr Asp Val Lys 
    530                 535                 540                 


Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu Asp Met Leu Ser Arg 
545                 550                 555                 560 


Ile Lys Tyr Leu Gln Thr Arg Ile Asp Met Ile Phe Thr Pro Gly Pro 
                565                 570                 575     


Pro Ser Thr Pro Lys His Lys Lys Ser Gln Lys Gly Ser Ala Phe Thr 
            580                 585                 590         


Phe Pro Ser Gln Gln Ser Pro Arg Asn Glu Pro Tyr Val Ala Arg Pro 
        595                 600                 605             


Ser Thr Ser Glu Ile Glu Asp Gln Ser Met Met Gly Lys Phe Val Lys 
    610                 615                 620                 


Val Glu Arg Gln Val Gln Asp Met Gly Lys Lys Leu Asp Phe Leu Val 
625                 630                 635                 640 


Asp Met His Met Gln His Met Glu Arg Leu Gln Val Gln Val Thr Glu 
                645                 650                 655     


Tyr Tyr Pro Thr Lys Gly Thr Ser Ser Pro Ala Glu Ala Glu Lys Lys 
            660                 665                 670         


Glu Asp Asn Arg Tyr Ser Asp Leu Lys Thr Ile Ile Cys Asn Tyr Ser 
        675                 680                 685             


Glu Thr Gly Pro Pro Glu Pro Pro Tyr Ser Phe His Gln Val Thr Ile 
    690                 695                 700                 


Asp Lys Val Ser Pro Tyr Gly Phe Phe Ala His Asp Pro Val Asn Leu 
705                 710                 715                 720 


Pro Arg Gly Gly Pro Ser Ser Gly Lys Val Gln Ala Thr Pro Pro Ser 
                725                 730                 735     


Ser Ala Thr Thr Tyr Val Glu Arg Pro Thr Val Leu Pro Ile Leu Thr 
            740                 745                 750         


Leu Leu Asp Ser Arg Val Ser Cys His Ser Gln Ala Asp Leu Gln Gly 
        755                 760                 765             


Pro Tyr Ser Asp Arg Ile Ser Pro Arg Gln Arg Arg Ser Ile Thr Arg 
    770                 775                 780                 


Asp Ser Asp Thr Pro Leu Ser Leu Met Ser Val Asn His Glu Glu Leu 
785                 790                 795                 800 


Glu Arg Ser Pro Ser Gly Phe Ser Ile Ser Gln Asp Arg Asp Asp Tyr 
                805                 810                 815     


Val Phe Gly Pro Asn Gly Gly Ser Ser Trp Met Arg Glu Lys Arg Tyr 
            820                 825                 830         


Leu Ala Glu Gly Glu Thr Asp Thr Asp Thr Asp Pro Phe Thr Pro Ser 
        835                 840                 845             


Gly Ser Met Pro Leu Ser Ser Thr Gly Asp Gly Ile Ser Asp Ser Val 
    850                 855                 860                 


Trp Thr Pro Ser Asn Lys Pro Ile 
865                 870         


<210> 243
<211> 348
<212> PRT
<213> Homo sapiens

<400> 243
Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210> 244
<211> 1218
<212> PRT
<213> Homo sapiens

<400> 244
Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210> 245
<211> 2758
<212> PRT
<213> Homo sapiens

<400> 245
Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Thr Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Val Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Ser Thr Gly Glu Asn Ala Leu 
        675                 680                 685             


Glu Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser 
    690                 695                 700                 


Asn Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala 
705                 710                 715                 720 


Lys Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr 
                725                 730                 735     


Gln Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala 
            740                 745                 750         


Ile Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys 
        755                 760                 765             


Met Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg 
    770                 775                 780                 


Leu Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr 
785                 790                 795                 800 


Pro Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala 
                805                 810                 815     


Ile Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu 
            820                 825                 830         


Arg Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val 
        835                 840                 845             


Val Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr 
    850                 855                 860                 


Phe Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr 
865                 870                 875                 880 


Asn Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu 
                885                 890                 895     


Asp Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Ala Lys 
            900                 905                 910         


Gly Glu Glu Asn Lys Gly Asn Asn Asp Val Glu Lys Leu Lys Ser Ser 
        915                 920                 925             


Asn Val Met Arg Ser Ile His Gly Val Gly Glu Leu Met Thr Gln Val 
    930                 935                 940                 


Val Leu Arg Gly Gly Gly Phe Leu Pro Met Thr Pro Met Ala Ala Ala 
945                 950                 955                 960 


Pro Glu Gly Asn Val Lys Gln Ala Glu Pro Glu Lys Glu Asp Ile Met 
                965                 970                 975     


Val Met Asp Thr Lys Leu Lys Ile Ile Glu Ile Leu Gln Phe Ile Leu 
            980                 985                 990         


Asn Val Arg Leu Asp Tyr Arg Ile  Ser Cys Leu Leu Cys  Ile Phe Lys 
        995                 1000                 1005             


Arg Glu  Phe Asp Glu Ser Asn  Ser Gln Thr Ser Glu  Thr Ser Ser 
    1010                 1015                 1020             


Gly Asn  Ser Ser Gln Glu Gly  Pro Ser Asn Val Pro  Gly Ala Leu 
    1025                 1030                 1035             


Asp Phe  Glu His Ile Glu Glu  Gln Ala Glu Gly Ile  Phe Gly Gly 
    1040                 1045                 1050             


Ser Glu  Glu Asn Thr Pro Leu  Asp Leu Asp Asp His  Gly Gly Arg 
    1055                 1060                 1065             


Thr Phe  Leu Arg Val Leu Leu  His Leu Thr Met His  Asp Tyr Pro 
    1070                 1075                 1080             


Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu Phe Arg  His Phe Ser 
    1085                 1090                 1095             


Gln Arg  Gln Glu Val Leu Gln  Ala Phe Lys Gln Val  Gln Leu Leu 
    1100                 1105                 1110             


Val Thr  Ser Gln Asp Val Asp  Asn Tyr Lys Gln Ile  Lys Gln Asp 
    1115                 1120                 1125             


Leu Asp  Gln Leu Arg Ser Ile  Val Glu Lys Ser Glu  Leu Trp Val 
    1130                 1135                 1140             


Tyr Lys  Gly Gln Gly Pro Asp  Glu Thr Met Asp Gly  Ala Ser Gly 
    1145                 1150                 1155             


Glu Asn  Glu His Lys Lys Thr  Glu Glu Gly Asn Asn  Lys Pro Gln 
    1160                 1165                 1170             


Lys His  Glu Ser Thr Ser Ser  Tyr Asn Tyr Arg Val  Val Lys Glu 
    1175                 1180                 1185             


Ile Leu  Ile Arg Leu Ser Lys  Leu Cys Val Gln Glu  Ser Ala Ser 
    1190                 1195                 1200             


Val Arg  Lys Ser Arg Lys Gln  Gln Gln Arg Leu Leu  Arg Asn Met 
    1205                 1210                 1215             


Gly Ala  His Ala Val Val Leu  Glu Leu Leu Gln Ile  Pro Tyr Glu 
    1220                 1225                 1230             


Lys Ala  Glu Asp Thr Lys Met  Gln Glu Ile Met Arg  Leu Ala His 
    1235                 1240                 1245             


Glu Phe  Leu Gln Asn Phe Cys  Ala Gly Asn Gln Gln  Asn Gln Ala 
    1250                 1255                 1260             


Leu Leu  His Lys His Ile Asn  Leu Phe Leu Asn Pro  Gly Ile Leu 
    1265                 1270                 1275             


Glu Ala  Val Thr Met Gln His  Ile Phe Met Asn Asn  Phe Gln Leu 
    1280                 1285                 1290             


Cys Ser  Glu Ile Asn Glu Arg  Val Val Gln His Phe  Val His Cys 
    1295                 1300                 1305             


Ile Glu  Thr His Gly Arg Asn  Val Gln Tyr Ile Lys  Phe Leu Gln 
    1310                 1315                 1320             


Thr Ile  Val Lys Ala Glu Gly  Lys Phe Ile Lys Lys  Cys Gln Asp 
    1325                 1330                 1335             


Met Val  Met Ala Glu Leu Val  Asn Ser Gly Glu Asp  Val Leu Val 
    1340                 1345                 1350             


Phe Tyr  Asn Asp Arg Ala Ser  Phe Gln Thr Leu Ile  Gln Met Met 
    1355                 1360                 1365             


Arg Ser  Glu Arg Asp Arg Met  Asp Glu Asn Ser Pro  Leu Met Tyr 
    1370                 1375                 1380             


His Ile  His Leu Val Glu Leu  Leu Ala Val Cys Thr  Glu Gly Lys 
    1385                 1390                 1395             


Asn Val  Tyr Thr Glu Ile Lys  Cys Asn Ser Leu Leu  Pro Leu Asp 
    1400                 1405                 1410             


Asp Ile  Val Arg Val Val Thr  His Glu Asp Cys Ile  Pro Glu Val 
    1415                 1420                 1425             


Lys Ile  Ala Tyr Ile Asn Phe  Leu Asn His Cys Tyr  Val Asp Thr 
    1430                 1435                 1440             


Glu Val  Glu Met Lys Glu Ile  Tyr Thr Ser Asn His  Met Trp Lys 
    1445                 1450                 1455             


Leu Phe  Glu Asn Phe Leu Val  Asp Ile Cys Arg Ala  Cys Asn Asn 
    1460                 1465                 1470             


Thr Ser  Asp Arg Lys His Ala  Asp Ser Ile Leu Glu  Lys Tyr Val 
    1475                 1480                 1485             


Thr Glu  Ile Val Met Ser Ile  Val Thr Thr Phe Phe  Ser Ser Pro 
    1490                 1495                 1500             


Phe Ser  Asp Gln Ser Thr Thr  Leu Gln Thr Arg Gln  Pro Val Phe 
    1505                 1510                 1515             


Val Gln  Leu Leu Gln Gly Val  Phe Arg Val Tyr His  Cys Asn Trp 
    1520                 1525                 1530             


Leu Met  Pro Ser Gln Lys Ala  Ser Val Glu Ser Cys  Ile Arg Val 
    1535                 1540                 1545             


Leu Ser  Asp Val Ala Lys Ser  Arg Ala Ile Ala Ile  Pro Val Asp 
    1550                 1555                 1560             


Leu Asp  Ser Gln Val Asn Asn  Leu Phe Leu Lys Ser  His Ser Ile 
    1565                 1570                 1575             


Val Gln  Lys Thr Ala Met Asn  Trp Arg Leu Ser Ala  Arg Asn Ala 
    1580                 1585                 1590             


Ala Arg  Arg Asp Ser Val Leu  Ala Ala Ser Arg Asp  Tyr Arg Asn 
    1595                 1600                 1605             


Ile Ile  Glu Arg Leu Gln Asp  Ile Val Ser Ala Leu  Glu Asp Arg 
    1610                 1615                 1620             


Leu Arg  Pro Leu Val Gln Ala  Glu Leu Ser Val Leu  Val Asp Val 
    1625                 1630                 1635             


Leu His  Arg Pro Glu Leu Leu  Phe Pro Glu Asn Thr  Asp Ala Arg 
    1640                 1645                 1650             


Arg Lys  Cys Glu Ser Gly Gly  Phe Ile Cys Lys Leu  Ile Lys His 
    1655                 1660                 1665             


Thr Lys  Gln Leu Leu Glu Glu  Asn Glu Glu Lys Leu  Cys Ile Lys 
    1670                 1675                 1680             


Val Leu  Gln Thr Leu Arg Glu  Met Met Thr Lys Asp  Arg Gly Tyr 
    1685                 1690                 1695             


Gly Glu  Lys Leu Ile Ser Ile  Asp Glu Leu Asp Asn  Ala Glu Leu 
    1700                 1705                 1710             


Pro Pro  Ala Pro Asp Ser Glu  Asn Ala Thr Glu Glu  Leu Glu Pro 
    1715                 1720                 1725             


Ser Pro  Pro Leu Arg Gln Leu  Glu Asp His Lys Arg  Gly Glu Ala 
    1730                 1735                 1740             


Leu Arg  Gln Val Leu Val Asn  Arg Tyr Tyr Gly Asn  Val Arg Pro 
    1745                 1750                 1755             


Ser Gly  Arg Arg Glu Ser Leu  Thr Ser Phe Gly Asn  Gly Pro Leu 
    1760                 1765                 1770             


Ser Ala  Gly Gly Pro Gly Lys  Pro Gly Gly Gly Gly  Gly Gly Ser 
    1775                 1780                 1785             


Gly Ser  Ser Ser Met Ser Arg  Gly Glu Met Ser Leu  Ala Glu Val 
    1790                 1795                 1800             


Gln Cys  His Leu Asp Lys Glu  Gly Ala Ser Asn Leu  Val Ile Asp 
    1805                 1810                 1815             


Leu Ile  Met Asn Ala Ser Ser  Asp Arg Val Phe His  Glu Ser Ile 
    1820                 1825                 1830             


Leu Leu  Ala Ile Ala Leu Leu  Glu Gly Gly Asn Thr  Thr Ile Gln 
    1835                 1840                 1845             


His Ser  Phe Phe Cys Arg Leu  Thr Glu Asp Lys Lys  Ser Glu Lys 
    1850                 1855                 1860             


Phe Phe  Lys Val Phe Tyr Asp  Arg Met Lys Val Ala  Gln Gln Glu 
    1865                 1870                 1875             


Ile Lys  Ala Thr Val Thr Val  Asn Thr Ser Asp Leu  Gly Asn Lys 
    1880                 1885                 1890             


Lys Lys  Asp Asp Glu Val Asp  Arg Asp Ala Pro Ser  Arg Lys Lys 
    1895                 1900                 1905             


Ala Lys  Glu Pro Thr Thr Gln  Ile Thr Glu Glu Val  Arg Asp Gln 
    1910                 1915                 1920             


Leu Leu  Glu Ala Ser Ala Ala  Thr Arg Lys Ala Phe  Thr Thr Phe 
    1925                 1930                 1935             


Arg Arg  Glu Ala Asp Pro Asp  Asp His Tyr Gln Pro  Gly Glu Gly 
    1940                 1945                 1950             


Thr Gln  Ala Thr Ala Asp Lys  Ala Lys Asp Asp Leu  Glu Met Ser 
    1955                 1960                 1965             


Ala Val  Ile Thr Ile Met Gln  Pro Ile Leu Arg Phe  Leu Gln Leu 
    1970                 1975                 1980             


Leu Cys  Glu Asn His Asn Arg  Asp Leu Gln Asn Phe  Leu Arg Cys 
    1985                 1990                 1995             


Gln Asn  Asn Lys Thr Asn Tyr  Asn Leu Val Cys Glu  Thr Leu Gln 
    2000                 2005                 2010             


Phe Leu  Asp Cys Ile Cys Gly  Ser Thr Thr Gly Gly  Leu Gly Leu 
    2015                 2020                 2025             


Leu Gly  Leu Tyr Ile Asn Glu  Lys Asn Val Ala Leu  Ile Asn Gln 
    2030                 2035                 2040             


Thr Leu  Glu Ser Leu Thr Glu  Tyr Cys Gln Gly Pro  Cys His Glu 
    2045                 2050                 2055             


Asn Gln  Asn Cys Ile Ala Thr  His Glu Ser Asn Gly  Ile Asp Ile 
    2060                 2065                 2070             


Ile Thr  Ala Leu Ile Leu Asn  Asp Ile Asn Pro Leu  Gly Lys Lys 
    2075                 2080                 2085             


Arg Met  Asp Leu Val Leu Glu  Leu Lys Asn Asn Ala  Ser Lys Leu 
    2090                 2095                 2100             


Leu Leu  Ala Ile Met Glu Ser  Arg His Asp Ser Glu  Asn Ala Glu 
    2105                 2110                 2115             


Arg Ile  Leu Tyr Asn Met Arg  Pro Lys Glu Leu Val  Glu Val Ile 
    2120                 2125                 2130             


Lys Lys  Ala Tyr Met Gln Gly  Glu Val Glu Phe Glu  Asp Gly Glu 
    2135                 2140                 2145             


Asn Gly  Glu Asp Gly Ala Ala  Ser Pro Arg Asn Val  Gly His Asn 
    2150                 2155                 2160             


Ile Tyr  Ile Leu Ala His Gln  Leu Ala Arg His Asn  Lys Glu Leu 
    2165                 2170                 2175             


Gln Ser  Met Leu Lys Pro Gly  Gly Gln Val Asp Gly  Asp Glu Ala 
    2180                 2185                 2190             


Leu Glu  Phe Tyr Ala Lys His  Thr Ala Gln Ile Glu  Ile Val Arg 
    2195                 2200                 2205             


Leu Asp  Arg Thr Met Glu Gln  Ile Val Phe Pro Val  Pro Ser Ile 
    2210                 2215                 2220             


Cys Glu  Phe Leu Thr Lys Glu  Ser Lys Leu Arg Ile  Tyr Tyr Thr 
    2225                 2230                 2235             


Thr Glu  Arg Asp Glu Gln Gly  Ser Lys Ile Asn Asp  Phe Phe Leu 
    2240                 2245                 2250             


Arg Ser  Glu Asp Leu Phe Asn  Glu Met Asn Trp Gln  Lys Lys Leu 
    2255                 2260                 2265             


Arg Ala  Gln Pro Val Leu Tyr  Trp Cys Ala Arg Asn  Met Ser Phe 
    2270                 2275                 2280             


Trp Ser  Ser Ile Ser Phe Asn  Leu Ala Val Leu Met  Asn Leu Leu 
    2285                 2290                 2295             


Val Ala  Phe Phe Tyr Pro Phe  Lys Gly Val Arg Gly  Gly Thr Leu 
    2300                 2305                 2310             


Glu Pro  His Trp Ser Gly Leu  Leu Trp Thr Ala Met  Leu Ile Ser 
    2315                 2320                 2325             


Leu Ala  Ile Val Ile Ala Leu  Pro Lys Pro His Gly  Ile Arg Ala 
    2330                 2335                 2340             


Leu Ile  Ala Ser Thr Ile Leu  Arg Leu Ile Phe Ser  Val Gly Leu 
    2345                 2350                 2355             


Gln Pro  Thr Leu Phe Leu Leu  Gly Ala Phe Asn Val  Cys Asn Lys 
    2360                 2365                 2370             


Ile Ile  Phe Leu Met Ser Phe  Val Gly Asn Cys Gly  Thr Phe Thr 
    2375                 2380                 2385             


Arg Gly  Tyr Arg Ala Met Val  Leu Asp Val Glu Phe  Leu Tyr His 
    2390                 2395                 2400             


Leu Leu  Tyr Leu Val Ile Cys  Ala Met Gly Leu Phe  Val His Glu 
    2405                 2410                 2415             


Phe Phe  Tyr Ser Leu Leu Leu  Phe Asp Leu Val Tyr  Arg Glu Glu 
    2420                 2425                 2430             


Thr Leu  Leu Asn Val Ile Lys  Ser Val Thr Arg Asn  Gly Arg Ser 
    2435                 2440                 2445             


Ile Ile  Leu Thr Ala Val Leu  Ala Leu Ile Leu Val  Tyr Leu Phe 
    2450                 2455                 2460             


Ser Ile  Val Gly Tyr Leu Phe  Phe Lys Asp Asp Phe  Ile Leu Glu 
    2465                 2470                 2475             


Val Asp  Arg Leu Pro Asn Glu  Thr Ala Val Pro Glu  Thr Gly Glu 
    2480                 2485                 2490             


Ser Leu  Ala Ser Glu Phe Leu  Phe Ser Asp Val Cys  Arg Val Glu 
    2495                 2500                 2505             


Ser Gly  Glu Asn Cys Ser Ser  Pro Ala Pro Arg Glu  Glu Leu Val 
    2510                 2515                 2520             


Pro Ala  Glu Glu Thr Glu Gln  Asp Lys Glu His Thr  Cys Glu Thr 
    2525                 2530                 2535             


Leu Leu  Met Cys Ile Val Thr  Val Leu Ser His Gly  Leu Arg Ser 
    2540                 2545                 2550             


Gly Gly  Gly Val Gly Asp Val  Leu Arg Lys Pro Ser  Lys Glu Glu 
    2555                 2560                 2565             


Pro Leu  Phe Ala Ala Arg Val  Ile Tyr Asp Leu Leu  Phe Phe Phe 
    2570                 2575                 2580             


Met Val  Ile Ile Ile Val Leu  Asn Leu Ile Phe Gly  Val Ile Ile 
    2585                 2590                 2595             


Asp Thr  Phe Ala Asp Leu Arg  Ser Glu Lys Gln Lys  Lys Glu Glu 
    2600                 2605                 2610             


Ile Leu  Lys Thr Thr Cys Phe  Ile Cys Gly Leu Glu  Arg Asp Lys 
    2615                 2620                 2625             


Phe Asp  Asn Lys Thr Val Thr  Phe Glu Glu His Ile  Lys Glu Glu 
    2630                 2635                 2640             


His Asn  Met Trp His Tyr Leu  Cys Phe Ile Val Leu  Val Lys Val 
    2645                 2650                 2655             


Lys Asp  Ser Thr Glu Tyr Thr  Gly Pro Glu Ser Tyr  Val Ala Glu 
    2660                 2665                 2670             


Met Ile  Lys Glu Arg Asn Leu  Asp Trp Phe Pro Arg  Met Arg Ala 
    2675                 2680                 2685             


Met Ser  Leu Val Ser Ser Asp  Ser Glu Gly Glu Gln  Asn Glu Leu 
    2690                 2695                 2700             


Arg Asn  Leu Gln Glu Lys Leu  Glu Ser Thr Met Lys  Leu Val Thr 
    2705                 2710                 2715             


Asn Leu  Ser Gly Gln Leu Ser  Glu Leu Lys Asp Gln  Met Thr Glu 
    2720                 2725                 2730             


Gln Arg  Lys Gln Lys Gln Arg  Ile Gly Leu Leu Gly  His Pro Pro 
    2735                 2740                 2745             


His Met  Asn Val Asn Pro Gln  Gln Pro Ala 
    2750                 2755             


<210> 246
<211> 413
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide
      
<400> 246
Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Gly 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Glu Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu 
                405                 410             


<210> 247
<211> 380
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide
      
<400> 247
Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val 
    370                 375                 380 


<210> 248
<211> 466
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide
      
<400> 248
Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg 
465     


<210> 249
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 249
Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210> 250
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 250
Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210> 251
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 251
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 252
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 252
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 253
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 253
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 254
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 254
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 255
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 255
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Arg Tyr 
            20                  25                  30          


Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 256
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 256
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ala Leu Asn 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile His Ser Gly Gly Thr Thr Asn Tyr Ala Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Lys Asp Phe Gly Ala Ile Ile Tyr Asp Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210> 257
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 257
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Arg Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser Glu Arg Thr Ser Tyr 
            20                  25                  30          


Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala Asn Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser Pro Tyr Asp Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser His His His His 
        115                 120                 125             


His His Glu Pro Glu Ala 
    130                 


<210> 258
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 258
Gly Pro Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp 
            20                  25                  30          


Phe Asp Asn Phe Asp Asp Tyr Ala Ile Gly Trp Phe Arg Gln Ala Pro 
        35                  40                  45              


Gly Gln Glu Arg Glu Gly Val Ser Cys Ile Asp Pro Ser Asp Gly Ser 
    50                  55                  60                  


Thr Ile Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Ser Asp 
65                  70                  75                  80  


Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
                85                  90                  95      


Asp Thr Ala Val Tyr Val Cys Ser Ala Trp Thr Leu Phe His Ser Asp 
            100                 105                 110         


Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210> 259
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 259
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 260
<211> 195
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 260
Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys 
1               5                   10                  15      


Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly 
            20                  25                  30          


Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser 
        35                  40                  45              


Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala Asp His 
    50                  55                  60                  


Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile 
65                  70                  75                  80  


Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu 
                85                  90                  95      


Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly 
            100                 105                 110         


Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro 
        115                 120                 125             


Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly 
    130                 135                 140                 


His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp 
145                 150                 155                 160 


Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu 
                165                 170                 175     


Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn 
            180                 185                 190         


Ala Cys Ser 
        195 


<210> 261
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 261
Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys Asn Arg Met Lys 
1               5                   10                  15      


Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly Val Val Glu Gly 
            20                  25                  30          


Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly Gly Asp Ile Ala 
        35                  40                  45              


Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn Arg Pro Ser Ala 
    50                  55                  60                  


Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile Arg Phe Gln Arg 
65                  70                  75                  80  


Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser Gln Gln Ala Ala 
                85                  90                  95      


Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr Glu Gln Ile Arg 
            100                 105                 110         


Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly Asp Phe Ala Cys 
        115                 120                 125             


Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro Ala Asp Ile Glu 
    130                 135                 140                 


Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp Glu Val Leu Asp 
145                 150                 155                 160 


Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro Ile Ile Asn Trp 
                165                 170                 175     


Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu Tyr Ala Leu Trp 
            180                 185                 190         


Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val Leu Gln Ala Thr 
        195                 200                 205             


Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys Ala Leu His Asp 
    210                 215                 220                 


Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg Trp Lys Asp Trp 
225                 230                 235                 240 


Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe Ser Leu Arg Glu 
                245                 250                 255     


Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser Leu Ala Ser Gln 
            260                 265                 270         


Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val Leu Ala His Ile 
        275                 280                 285             


Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr Tyr Lys Ser Phe 
    290                 295                 300                 


Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly Val Tyr Leu Pro 
305                 310                 315                 320 


Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro Ile Ala Leu Gly 
                325                 330                 335     


Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met Glu Asn Asp Gly 
            340                 345                 350         


Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr Asp Asp Asp Val 
        355                 360                 365             


Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg Lys Leu Leu His 
    370                 375                 380                 


Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu Glu Gln Gln Glu 
385                 390                 395                 400 


Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr Glu Gly Gly Val 
                405                 410                 415     


Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn His Pro Leu Val 
            420                 425                 430         


Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg Gln Ile Arg Pro 
        435                 440                 445             


Cys Thr Ser Leu Ser 
    450             


<210> 262
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 262
Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly Ser Gly His 
1               5                   10                  15      


Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn Ala Val Leu 
            20                  25                  30          


Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys Leu Arg Arg 
        35                  40                  45              


Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln Glu Leu Thr 
    50                  55                  60                  


Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro Asp Ser Cys 
65                  70                  75                  80  


Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln Lys Tyr Val 
                85                  90                  95      


Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu Lys 
            100                 105                 110         


Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg Gly Arg Arg 
        115                 120                 125             


Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro Pro Arg Arg 
    130                 135                 140                 


Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp Asp Arg Ala 
145                 150                 155                 160 


Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser Lys Ile Val 
                165                 170                 175     


Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys Gln Ala Cys 
            180                 185                 190         


Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu Ser Leu Pro 
        195                 200                 205             


Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu Arg Asp Cys 
    210                 215                 220                 


Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu Asn Ala Pro 
225                 230                 235                 240 


Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys Lys Leu Thr 
                245                 250                 255     


Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn Arg Phe Ser 
            260                 265                 270         


Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val Asp Phe Pro 
        275                 280                 285             


Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys Ala Gly Ser 
    290                 295                 300                 


Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly Ser Val His 
305                 310                 315                 320 


Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly Trp His Val 
                325                 330                 335     


Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln Val Ala Ser 
            340                 345                 350         


Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu Pro Pro Arg 
        355                 360                 365             


Cys Leu 
    370 


<210> 263
<211> 175
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 263
Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly Leu Tyr Arg Lys 
1               5                   10                  15      


Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala Val Ala Glu Gln 
            20                  25                  30          


Val Leu His Ser Gln Ser Arg His Val Glu Val Arg Met Ala Cys Ile 
        35                  40                  45              


His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala Phe Ile Glu Gly 
    50                  55                  60                  


Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro Gln Glu Trp Val 
65                  70                  75                  80  


Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr Arg Lys Asp Phe 
                85                  90                  95      


Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln Val Thr Glu Asn 
            100                 105                 110         


Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn Gly Asn His Tyr 
        115                 120                 125             


Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser Ala Met Cys Gln 
    130                 135                 140                 


Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe Lys Thr Asp Val 
145                 150                 155                 160 


Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val Ala Asp Glu 
                165                 170                 175 


<210> 264
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 264
Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210> 265
<211> 909
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 265
Met Gly Gln Pro Gly Asn Gly Ser Ala Phe Leu Leu Ala Pro Asn Gly 
1               5                   10                  15      


Ser His Ala Pro Asp His Asp Val Thr Gln Glu Arg Asp Glu Val Trp 
            20                  25                  30          


Val Val Gly Met Gly Ile Val Met Ser Leu Ile Val Leu Ala Ile Val 
        35                  40                  45              


Phe Gly Asn Val Leu Val Ile Thr Ala Ile Ala Lys Phe Glu Arg Leu 
    50                  55                  60                  


Gln Thr Val Thr Asn Tyr Phe Ile Thr Ser Leu Ala Cys Ala Asp Leu 
65                  70                  75                  80  


Val Met Gly Leu Ala Val Val Pro Phe Gly Ala Ala His Ile Leu Met 
                85                  90                  95      


Lys Met Trp Thr Phe Gly Asn Phe Trp Cys Glu Phe Trp Thr Ser Ile 
            100                 105                 110         


Asp Val Leu Cys Val Thr Ala Ser Ile Glu Thr Leu Cys Val Ile Ala 
        115                 120                 125             


Val Asp Arg Tyr Phe Ala Ile Thr Ser Pro Phe Lys Tyr Gln Ser Leu 
    130                 135                 140                 


Leu Thr Lys Asn Lys Ala Arg Val Ile Ile Leu Met Val Trp Ile Val 
145                 150                 155                 160 


Ser Gly Leu Thr Ser Phe Leu Pro Ile Gln Met His Trp Tyr Arg Ala 
                165                 170                 175     


Thr His Gln Glu Ala Ile Asn Cys Tyr Ala Asn Glu Thr Cys Cys Asp 
            180                 185                 190         


Phe Phe Thr Asn Gln Ala Tyr Ala Ile Ala Ser Ser Ile Val Ser Phe 
        195                 200                 205             


Tyr Val Pro Leu Val Ile Met Val Phe Val Tyr Ser Arg Val Phe Gln 
    210                 215                 220                 


Glu Ala Lys Arg Gln Leu Gln Lys Ile Asp Lys Ser Glu Gly Arg Phe 
225                 230                 235                 240 


His Val Gln Asn Leu Ser Gln Val Glu Gln Asp Gly Arg Thr Gly His 
                245                 250                 255     


Gly Leu Arg Arg Ser Ser Lys Phe Cys Leu Lys Glu His Lys Ala Leu 
            260                 265                 270         


Lys Thr Leu Gly Ile Ile Met Gly Thr Phe Thr Leu Cys Trp Leu Pro 
        275                 280                 285             


Phe Phe Ile Val Asn Ile Val His Val Ile Gln Asp Asn Leu Ile Arg 
    290                 295                 300                 


Lys Glu Val Tyr Ile Leu Leu Asn Trp Ile Gly Tyr Val Asn Ser Gly 
305                 310                 315                 320 


Phe Asn Pro Leu Ile Tyr Cys Arg Ser Pro Asp Phe Arg Ile Ala Phe 
                325                 330                 335     


Gln Glu Leu Leu Cys Leu Arg Arg Ser Ser Leu Lys Ala Tyr Gly Asn 
            340                 345                 350         


Gly Tyr Ser Ser Asn Gly Asn Thr Gly Glu Gln Ser Gly Tyr His Val 
        355                 360                 365             


Glu Gln Glu Lys Glu Asn Lys Leu Leu Cys Glu Asp Leu Pro Gly Thr 
    370                 375                 380                 


Glu Asp Phe Val Gly His Gln Gly Thr Val Pro Ser Asp Asn Ile Asp 
385                 390                 395                 400 


Ser Gln Gly Arg Asn Cys Ser Thr Asn Asp Ser Leu Leu Val Ser Lys 
                405                 410                 415     


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
            420                 425                 430         


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
        435                 440                 445             


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
    450                 455                 460                 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
465                 470                 475                 480 


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
                485                 490                 495     


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
            500                 505                 510         


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
        515                 520                 525             


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
    530                 535                 540                 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
545                 550                 555                 560 


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
                565                 570                 575     


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
            580                 585                 590         


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
        595                 600                 605             


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
    610                 615                 620                 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
625                 630                 635                 640 


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Ser Gly Ala Thr 
                645                 650                 655     


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
            660                 665                 670         


Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu 
        675                 680                 685             


Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu 
    690                 695                 700                 


Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln 
705                 710                 715                 720 


Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp 
                725                 730                 735     


Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys 
            740                 745                 750         


His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly 
        755                 760                 765             


Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr 
    770                 775                 780                 


Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val 
785                 790                 795                 800 


Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys 
                805                 810                 815     


Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp 
            820                 825                 830         


Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly 
        835                 840                 845             


Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro 
    850                 855                 860                 


Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr 
865                 870                 875                 880 


Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu 
                885                 890                 895     


Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
            900                 905                 


<210> 266
<211> 876
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 266
Met Asp Ser Pro Ile Gln Ile Phe Arg Gly Glu Pro Gly Pro Thr Cys 
1               5                   10                  15      


Ala Pro Ser Ala Cys Leu Pro Pro Asn Ser Ser Ala Trp Phe Pro Gly 
            20                  25                  30          


Trp Ala Glu Pro Asp Ser Asn Gly Ser Ala Gly Ser Glu Asp Ala Gln 
        35                  40                  45              


Leu Glu Pro Ala His Ile Ser Pro Ala Ile Pro Val Ile Ile Thr Ala 
    50                  55                  60                  


Val Tyr Ser Val Val Phe Val Val Gly Leu Val Gly Asn Ser Leu Val 
65                  70                  75                  80  


Met Phe Val Ile Ile Arg Tyr Thr Lys Met Lys Thr Ala Thr Asn Ile 
                85                  90                  95      


Tyr Ile Phe Asn Leu Ala Leu Ala Asp Ala Leu Val Thr Thr Thr Met 
            100                 105                 110         


Pro Phe Gln Ser Thr Val Tyr Leu Met Asn Ser Trp Pro Phe Gly Asp 
        115                 120                 125             


Val Leu Cys Lys Ile Val Ile Ser Ile Asp Tyr Tyr Asn Met Phe Thr 
    130                 135                 140                 


Ser Ile Phe Thr Leu Thr Met Met Ser Val Asp Arg Tyr Ile Ala Val 
145                 150                 155                 160 


Cys His Pro Val Lys Ala Leu Asp Phe Arg Thr Pro Leu Lys Ala Lys 
                165                 170                 175     


Ile Ile Asn Ile Cys Ile Trp Leu Leu Ser Ser Ser Val Gly Ile Ser 
            180                 185                 190         


Ala Ile Val Leu Gly Gly Thr Lys Val Arg Glu Asp Val Asp Val Ile 
        195                 200                 205             


Glu Cys Ser Leu Gln Phe Pro Asp Asp Asp Tyr Ser Trp Trp Asp Leu 
    210                 215                 220                 


Phe Met Lys Ile Cys Val Phe Ile Phe Ala Phe Val Ile Pro Val Leu 
225                 230                 235                 240 


Ile Ile Ile Val Cys Tyr Thr Leu Met Ile Leu Arg Leu Lys Ser Val 
                245                 250                 255     


Arg Leu Leu Ser Gly Ser Arg Glu Lys Asp Arg Asn Leu Arg Arg Ile 
            260                 265                 270         


Thr Arg Leu Val Leu Val Val Val Ala Val Phe Val Val Cys Trp Thr 
        275                 280                 285             


Pro Ile His Ile Phe Ile Leu Val Glu Ala Leu Gly Ser Thr Ser His 
    290                 295                 300                 


Ser Thr Ala Ala Leu Ser Ser Tyr Tyr Phe Cys Ile Ala Leu Gly Tyr 
305                 310                 315                 320 


Thr Asn Ser Ser Leu Asn Pro Ile Leu Tyr Ala Phe Leu Asp Glu Asn 
                325                 330                 335     


Phe Lys Arg Cys Phe Arg Asp Phe Cys Phe Pro Leu Lys Met Arg Met 
            340                 345                 350         


Glu Arg Gln Ser Thr Ser Arg Val Arg Asn Thr Val Gln Asp Pro Ala 
        355                 360                 365             


Tyr Leu Arg Asp Ile Asp Gly Met Asn Lys Pro Val Val Ser Lys Gly 
    370                 375                 380                 


Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly 
385                 390                 395                 400 


Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp 
                405                 410                 415     


Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys 
            420                 425                 430         


Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu 
        435                 440                 445             


Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe 
    450                 455                 460                 


Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe 
465                 470                 475                 480 


Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly 
                485                 490                 495     


Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu 
            500                 505                 510         


Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His 
        515                 520                 525             


Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn 
    530                 535                 540                 


Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp 
545                 550                 555                 560 


His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro 
                565                 570                 575     


Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn 
            580                 585                 590         


Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly 
        595                 600                 605             


Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Ser Gly Ala Thr Asn 
    610                 615                 620                 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
625                 630                 635                 640 


Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
                645                 650                 655     


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            660                 665                 670         


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        675                 680                 685             


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    690                 695                 700                 


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
705                 710                 715                 720 


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                725                 730                 735     


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            740                 745                 750         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        755                 760                 765             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    770                 775                 780                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
785                 790                 795                 800 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                805                 810                 815     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            820                 825                 830         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        835                 840                 845             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    850                 855                 860                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
865                 870                 875     


<210> 267
<211> 962
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 267
Met Asn Asn Ser Thr Asn Ser Ser Asn Asn Ser Leu Ala Leu Thr Ser 
1               5                   10                  15      


Pro Tyr Lys Thr Phe Glu Val Val Phe Ile Val Leu Val Ala Gly Ser 
            20                  25                  30          


Leu Ser Leu Val Thr Ile Ile Gly Asn Ile Leu Val Met Val Ser Ile 
        35                  40                  45              


Lys Val Asn Arg His Leu Gln Thr Val Asn Asn Tyr Phe Leu Phe Ser 
    50                  55                  60                  


Leu Ala Cys Ala Asp Leu Ile Ile Gly Val Phe Ser Met Asn Leu Tyr 
65                  70                  75                  80  


Thr Leu Tyr Thr Val Ile Gly Tyr Trp Pro Leu Gly Pro Val Val Cys 
                85                  90                  95      


Asp Leu Trp Leu Ala Leu Asp Tyr Val Val Ser Asn Ala Ser Val Met 
            100                 105                 110         


Asn Leu Leu Ile Ile Ser Phe Asp Arg Tyr Phe Cys Val Thr Lys Pro 
        115                 120                 125             


Leu Thr Tyr Pro Val Lys Arg Thr Thr Lys Met Ala Gly Met Met Ile 
    130                 135                 140                 


Ala Ala Ala Trp Val Leu Ser Phe Ile Leu Trp Ala Pro Ala Ile Leu 
145                 150                 155                 160 


Phe Trp Gln Phe Ile Val Gly Val Arg Thr Val Glu Asp Gly Glu Cys 
                165                 170                 175     


Tyr Ile Gln Phe Phe Ser Asn Ala Ala Val Thr Phe Gly Thr Ala Ile 
            180                 185                 190         


Ala Ala Phe Tyr Leu Pro Val Ile Ile Met Thr Val Leu Tyr Trp His 
        195                 200                 205             


Ile Ser Arg Ala Ser Lys Ser Arg Ile Lys Lys Asp Lys Lys Glu Pro 
    210                 215                 220                 


Val Ala Asn Gln Asp Pro Val Ser Pro Ser Leu Val Gln Gly Arg Ile 
225                 230                 235                 240 


Val Lys Pro Asn Asn Asn Asn Met Pro Ser Ser Asp Asp Gly Leu Glu 
                245                 250                 255     


His Asn Lys Ile Gln Asn Gly Lys Ala Pro Arg Asp Pro Val Thr Glu 
            260                 265                 270         


Asn Cys Val Gln Gly Glu Glu Lys Glu Ser Ser Asn Asp Ser Thr Ser 
        275                 280                 285             


Val Ser Ala Val Ala Ser Asn Met Arg Asp Asp Glu Ile Thr Gln Asp 
    290                 295                 300                 


Glu Asn Thr Val Ser Thr Ser Leu Gly His Ser Lys Asp Glu Asn Ser 
305                 310                 315                 320 


Lys Gln Thr Cys Ile Arg Ile Gly Thr Lys Thr Pro Lys Ser Asp Ser 
                325                 330                 335     


Cys Thr Pro Thr Asn Thr Thr Val Glu Val Val Gly Ser Ser Gly Gln 
            340                 345                 350         


Asn Gly Asp Glu Lys Gln Asn Ile Val Ala Arg Lys Ile Val Lys Met 
        355                 360                 365             


Thr Lys Gln Pro Ala Lys Lys Lys Pro Pro Pro Ser Arg Glu Lys Lys 
    370                 375                 380                 


Val Thr Arg Thr Ile Leu Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp 
385                 390                 395                 400 


Ala Pro Tyr Asn Val Met Val Leu Ile Asn Thr Phe Cys Ala Pro Cys 
                405                 410                 415     


Ile Pro Asn Thr Val Trp Thr Ile Gly Tyr Trp Leu Cys Tyr Ile Asn 
            420                 425                 430         


Ser Thr Ile Asn Pro Ala Cys Tyr Ala Leu Cys Asn Ala Thr Phe Lys 
        435                 440                 445             


Lys Thr Phe Lys His Leu Leu Met Cys His Tyr Lys Asn Ile Gly Ala 
    450                 455                 460                 


Thr Arg Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
465                 470                 475                 480 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
                485                 490                 495     


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
            500                 505                 510         


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
        515                 520                 525             


Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met 
    530                 535                 540                 


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
545                 550                 555                 560 


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
                565                 570                 575     


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
            580                 585                 590         


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
        595                 600                 605             


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
    610                 615                 620                 


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
625                 630                 635                 640 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
                645                 650                 655     


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala 
            660                 665                 670         


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
        675                 680                 685             


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
    690                 695                 700                 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
705                 710                 715                 720 


Glu Glu Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met 
                725                 730                 735     


Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser 
            740                 745                 750         


Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro 
        755                 760                 765             


Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro 
    770                 775                 780                 


Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser 
785                 790                 795                 800 


Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu 
                805                 810                 815     


Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp 
            820                 825                 830         


Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu 
        835                 840                 845             


Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly 
    850                 855                 860                 


Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg 
865                 870                 875                 880 


Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu 
                885                 890                 895     


Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr 
            900                 905                 910         


Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile 
        915                 920                 925             


Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln 
    930                 935                 940                 


Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu 
945                 950                 955                 960 


Tyr Lys 
        


<210> 268
<211> 655
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 268
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser 
            260                 265                 270         


Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro 
        275                 280                 285             


Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu 
    290                 295                 300                 


Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg 
305                 310                 315                 320 


Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro 
                325                 330                 335     


Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr 
            340                 345                 350         


Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser 
        355                 360                 365             


Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser 
    370                 375                 380                 


Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp 
385                 390                 395                 400 


Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His 
                405                 410                 415     


Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys 
            420                 425                 430         


Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr 
        435                 440                 445             


Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln 
    450                 455                 460                 


Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met 
465                 470                 475                 480 


His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu 
                485                 490                 495     


Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala 
            500                 505                 510         


His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg 
        515                 520                 525             


Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr 
    530                 535                 540                 


Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val 
545                 550                 555                 560 


Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln 
                565                 570                 575     


Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu 
            580                 585                 590         


Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp 
        595                 600                 605             


Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile 
    610                 615                 620                 


Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val 
625                 630                 635                 640 


Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                645                 650                 655 


<210> 269
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 269
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val 
            260                 265                 270         


Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His 
        275                 280                 285             


Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val 
    290                 295                 300                 


Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His 
305                 310                 315                 320 


Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp 
                325                 330                 335     


Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly 
            340                 345                 350         


Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His 
        355                 360                 365             


Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile 
    370                 375                 380                 


His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser 
385                 390                 395                 400 


Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro 
                405                 410                 415     


Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys 
            420                 425                 430         


Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met 
        435                 440                 445             


Tyr Ile Glu Gln Asn Ala Cys Ser 
    450                 455     


<210> 270
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 270
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile 
            260                 265                 270         


Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val 
        275                 280                 285             


Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser 
    290                 295                 300                 


Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu 
305                 310                 315                 320 


Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala 
                325                 330                 335     


Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val 
            340                 345                 350         


Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu 
        355                 360                 365             


Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys 
    370                 375                 380                 


Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu 
385                 390                 395                 400 


Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe 
                405                 410                 415     


Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser 
            420                 425                 430         


Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg 
        435                 440                 445             


Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser 
    450                 455                 460                 


Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg 
465                 470                 475                 480 


Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr 
                485                 490                 495     


Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His 
            500                 505                 510         


Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu 
        515                 520                 525             


Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe 
    530                 535                 540                 


Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys 
545                 550                 555                 560 


Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln 
                565                 570                 575     


Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser 
            580                 585                 590         


Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala 
        595                 600                 605             


Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn 
    610                 615                 620                 


Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu 
625                 630                 635                 640 


Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn 
                645                 650                 655     


Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val 
            660                 665                 670         


Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg 
        675                 680                 685             


Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr 
    690                 695                 700                 


Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser 
705                 710                 


<210> 271
<211> 631
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 271
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ser Asp Asp Lys Met Ala His His Thr Leu Leu 
            260                 265                 270         


Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
        275                 280                 285             


Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp 
    290                 295                 300                 


Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg 
305                 310                 315                 320 


Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp 
                325                 330                 335     


His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val 
            340                 345                 350         


Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala 
        355                 360                 365             


Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn 
    370                 375                 380                 


Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro 
385                 390                 395                 400 


Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser 
                405                 410                 415     


Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu 
            420                 425                 430         


Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu 
        435                 440                 445             


Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys 
    450                 455                 460                 


Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val 
465                 470                 475                 480 


Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu 
                485                 490                 495     


Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser 
            500                 505                 510         


Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His 
        515                 520                 525             


Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val 
    530                 535                 540                 


Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser 
545                 550                 555                 560 


Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His 
                565                 570                 575     


Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln 
            580                 585                 590         


Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu 
        595                 600                 605             


Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met 
    610                 615                 620                 


Gln Glu Pro Pro Arg Cys Leu 
625                 630     


<210> 272
<211> 436
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 272
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            260                 265                 270         


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        275                 280                 285             


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    290                 295                 300                 


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
305                 310                 315                 320 


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                325                 330                 335     


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            340                 345                 350         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        355                 360                 365             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    370                 375                 380                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser 
385                 390                 395                 400 


Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val 
                405                 410                 415     


Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu 
            420                 425                 430         


Val Ala Asp Glu 
        435     


<210> 273
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 273
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser 
    370                 375                 380                 


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
385                 390                 395                 400 


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
                405                 410                 415     


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
            420                 425                 430         


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
        435                 440                 445             


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
    450                 455                 460                 


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
465                 470                 475                 480 


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
                485                 490                 495     


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
            500                 505                 510         


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
        515                 520                 525             


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
    530                 535                 540                 


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
545                 550                 555                 560 


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
                565                 570                 575     


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
            580                 585                 590         


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
        595                 600                 605             


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
    610                 615                 620                 


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
625                 630                 635                 640 


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
                645                 650                 655     


Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser 
            660                 665                 670         


Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser 
        675                 680                 685             


Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr 
    690                 695                 700                 


Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly 
705                 710                 715                 720 


Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala 
                725                 730                 735     


Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr 
            740                 745                 750         


Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu 
        755                 760                 765             


Ala Gln 
    770 


<210> 274
<211> 571
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 274
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Asp Glu Lys Leu Ala Leu Tyr Leu 
    370                 375                 380                 


Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr 
385                 390                 395                 400 


Arg Phe His Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser 
                405                 410                 415     


Lys Thr Val Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln 
            420                 425                 430         


Thr Val His Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile 
        435                 440                 445             


Glu Gly Asp Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala 
    450                 455                 460                 


Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val 
465                 470                 475                 480 


Asn Ile His Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser 
                485                 490                 495     


Thr Met Ile His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile 
            500                 505                 510         


Trp Leu Ser Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His 
        515                 520                 525             


Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val 
    530                 535                 540                 


Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu 
545                 550                 555                 560 


Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys Ser 
                565                 570     


<210> 275
<211> 828
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 275
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Leu Glu Val Asp Phe Lys Lys Leu 
    370                 375                 380                 


Lys Gln Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn 
385                 390                 395                 400 


Ala Cys Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr 
                405                 410                 415     


Lys Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val 
            420                 425                 430         


Arg Leu Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val 
        435                 440                 445             


His Leu Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu 
    450                 455                 460                 


Thr Glu Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys 
465                 470                 475                 480 


Pro Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His 
                485                 490                 495     


Gln Arg Lys Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr 
            500                 505                 510         


Phe Thr Leu Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu 
        515                 520                 525             


Lys Leu Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu 
    530                 535                 540                 


Glu Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu 
545                 550                 555                 560 


Asp Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu 
                565                 570                 575     


Leu Asp Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser 
            580                 585                 590         


Val Leu Arg Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp 
        595                 600                 605             


Phe Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe 
    610                 615                 620                 


Gly Leu His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala 
625                 630                 635                 640 


Phe Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr 
                645                 650                 655     


His Ile Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr 
            660                 665                 670         


Gly Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr 
        675                 680                 685             


Arg Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys 
    690                 695                 700                 


Trp Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala 
705                 710                 715                 720 


Leu Val Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala 
                725                 730                 735     


Asn Leu Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val 
            740                 745                 750         


Asp Ser Glu Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu 
        755                 760                 765             


Leu Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp 
    770                 775                 780                 


Cys Cys Val Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser 
785                 790                 795                 800 


Arg Arg Arg Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu 
                805                 810                 815     


Asp Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu 
            820                 825             


<210> 276
<211> 746
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 276
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Ser Asp Asp Lys Met Ala His His 
    370                 375                 380                 


Thr Leu Leu Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn 
385                 390                 395                 400 


Thr Cys Phe Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro 
                405                 410                 415     


Leu Arg Asp Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly 
            420                 425                 430         


Gly Gly Arg Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly 
        435                 440                 445             


Ala Leu Trp His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe 
    450                 455                 460                 


Arg Ala Val Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln 
465                 470                 475                 480 


Gln Asp Ala Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu 
                485                 490                 495     


Glu Ile Asn Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly 
            500                 505                 510         


Pro Val Pro Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro 
        515                 520                 525             


Glu Leu Ser Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu 
    530                 535                 540                 


Glu Arg Glu Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys 
545                 550                 555                 560 


Ser Cys Leu Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu 
                565                 570                 575     


Val Phe Cys Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly 
            580                 585                 590         


Gly Lys Val Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu 
        595                 600                 605             


Glu Leu Glu Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys 
    610                 615                 620                 


Thr Arg Ser Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu 
625                 630                 635                 640 


Val Leu His Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys 
                645                 650                 655     


Ser Ser Val Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp 
            660                 665                 670         


Phe Ala Ser Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu 
        675                 680                 685             


Cys Asn His Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys 
    690                 695                 700                 


Arg Cys Gln Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro 
705                 710                 715                 720 


Val Ser Glu Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr 
                725                 730                 735     


Gln Leu Met Gln Glu Pro Pro Arg Cys Leu 
            740                 745     


<210> 277
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 277
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Ala Thr Pro Met Asp Ala Tyr Leu 
    370                 375                 380                 


Arg Lys Leu Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys 
385                 390                 395                 400 


Leu Phe Arg Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His 
                405                 410                 415     


Val Glu Val Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu 
            420                 425                 430         


Lys Phe Glu Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg 
        435                 440                 445             


Leu Glu Asn Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu 
    450                 455                 460                 


Ser Leu Met Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val 
465                 470                 475                 480 


Ser Pro Ser Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu 
                485                 490                 495     


Cys Phe Ser Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr 
            500                 505                 510         


Lys Glu Ser Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr 
        515                 520                 525             


Glu Lys Val Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp 
    530                 535                 540                 


Thr Leu Glu Val Ala Asp Glu 
545                 550     


<210> 278
<211> 775
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 278
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
            260                 265                 270         


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        275                 280                 285             


Ile Phe Ala Leu Asn Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gln Arg Glu Leu Val Ala Ala Ile His Ser Gly Gly Thr Thr Asn Tyr 
305                 310                 315                 320 


Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala 
                325                 330                 335     


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Asn Val Lys Asp Phe Gly Ala Ile Ile Tyr Asp Tyr 
        355                 360                 365             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser 
    370                 375                 380                 


Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser 
385                 390                 395                 400 


Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp 
                405                 410                 415     


Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser 
            420                 425                 430         


Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly 
        435                 440                 445             


Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe 
    450                 455                 460                 


Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile 
465                 470                 475                 480 


Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala 
                485                 490                 495     


Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu 
            500                 505                 510         


Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala 
        515                 520                 525             


Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys 
    530                 535                 540                 


Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys 
545                 550                 555                 560 


Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu 
                565                 570                 575     


Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys 
            580                 585                 590         


Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn 
        595                 600                 605             


Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu 
    610                 615                 620                 


Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val 
625                 630                 635                 640 


Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala 
                645                 650                 655     


Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser 
            660                 665                 670         


Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe 
        675                 680                 685             


Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala 
    690                 695                 700                 


Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe 
705                 710                 715                 720 


Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp 
                725                 730                 735     


Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His 
            740                 745                 750         


Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp 
        755                 760                 765             


Ala Gln Ala Pro Leu Ala Gln 
    770                 775 


<210> 279
<211> 576
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 279
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
            260                 265                 270         


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        275                 280                 285             


Ile Phe Ala Leu Asn Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gln Arg Glu Leu Val Ala Ala Ile His Ser Gly Gly Thr Thr Asn Tyr 
305                 310                 315                 320 


Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala 
                325                 330                 335     


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Asn Val Lys Asp Phe Gly Ala Ile Ile Tyr Asp Tyr 
        355                 360                 365             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Asp Glu Lys 
    370                 375                 380                 


Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu Arg 
385                 390                 395                 400 


Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly Asn Cys Leu 
                405                 410                 415     


Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser Leu His Arg 
            420                 425                 430         


Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala Asp His Leu Asp His 
        435                 440                 445             


Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile Ile Ala Ala 
    450                 455                 460                 


Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met Gly 
465                 470                 475                 480 


Gln Met Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly Arg Leu Glu 
                485                 490                 495     


Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro Glu Asp Ser 
            500                 505                 510         


Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly His Tyr Asp 
        515                 520                 525             


Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp Cys 
    530                 535                 540                 


Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys Ser 
545                 550                 555                 560 


Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys Ser 
                565                 570                 575     


<210> 280
<211> 834
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 280
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
            260                 265                 270         


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        275                 280                 285             


Ile Phe Ala Leu Asn Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gln Arg Glu Leu Val Ala Ala Ile His Ser Gly Gly Thr Thr Asn Tyr 
305                 310                 315                 320 


Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala 
                325                 330                 335     


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Asn Val Lys Asp Phe Gly Ala Ile Ile Tyr Asp Tyr 
        355                 360                 365             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Leu Glu Val 
    370                 375                 380                 


Asp Phe Lys Lys Leu Lys Gln Ile Lys Asn Arg Met Lys Lys Thr Asp 
385                 390                 395                 400 


Trp Leu Phe Leu Asn Ala Cys Val Gly Val Val Glu Gly Asp Leu Ala 
                405                 410                 415     


Ala Ile Glu Ala Tyr Lys Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu 
            420                 425                 430         


Thr Ala Asp Glu Val Arg Leu Leu Asn Arg Pro Ser Ala Phe Asp Val 
        435                 440                 445             


Gly Tyr Thr Leu Val His Leu Ala Ile Arg Phe Gln Arg Gln Asp Met 
    450                 455                 460                 


Leu Ala Ile Leu Leu Thr Glu Val Ser Gln Gln Ala Ala Lys Cys Ile 
465                 470                 475                 480 


Pro Ala Met Val Cys Pro Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile 
                485                 490                 495     


Ala Ala Ser Leu His Gln Arg Lys Gly Asp Phe Ala Cys Tyr Phe Leu 
            500                 505                 510         


Thr Asp Leu Val Thr Phe Thr Leu Pro Ala Asp Ile Glu Asp Leu Pro 
        515                 520                 525             


Pro Thr Val Gln Glu Lys Leu Phe Asp Glu Val Leu Asp Arg Asp Val 
    530                 535                 540                 


Gln Lys Glu Leu Glu Glu Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu 
545                 550                 555                 560 


Leu Ala Thr Arg Leu Asp Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr 
                565                 570                 575     


Ala Gly Asp Cys Leu Leu Asp Ser Val Leu Gln Ala Thr Trp Gly Ile 
            580                 585                 590         


Tyr Asp Lys Asp Ser Val Leu Arg Lys Ala Leu His Asp Ser Leu His 
        595                 600                 605             


Asp Cys Ser His Trp Phe Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp 
    610                 615                 620                 


Tyr Ser Gln Ser Phe Gly Leu His Phe Ser Leu Arg Glu Glu Gln Trp 
625                 630                 635                 640 


Gln Glu Asp Trp Ala Phe Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala 
                645                 650                 655     


Ser Leu Glu Gln Thr His Ile Phe Val Leu Ala His Ile Leu Arg Arg 
            660                 665                 670         


Pro Ile Ile Val Tyr Gly Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu 
        675                 680                 685             


Thr Leu Gly Tyr Thr Arg Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp 
    690                 695                 700                 


Glu Gln Ser Phe Cys Trp Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg 
705                 710                 715                 720 


Gly His Phe Ser Ala Leu Val Ala Met Glu Asn Asp Gly Tyr Gly Asn 
                725                 730                 735     


Arg Gly Ala Gly Ala Asn Leu Asn Thr Asp Asp Asp Val Thr Ile Thr 
            740                 745                 750         


Phe Leu Pro Leu Val Asp Ser Glu Arg Lys Leu Leu His Val His Phe 
        755                 760                 765             


Leu Ser Ala Gln Glu Leu Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu 
    770                 775                 780                 


Arg Glu Trp Leu Asp Cys Cys Val Thr Glu Gly Gly Val Leu Val Ala 
785                 790                 795                 800 


Met Gln Lys Ser Ser Arg Arg Arg Asn His Pro Leu Val Thr Gln Met 
                805                 810                 815     


Val Glu Lys Trp Leu Asp Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser 
            820                 825                 830         


Leu Ser 
        


<210> 281
<211> 736
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 281
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Gln Val Gln Leu Gln Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Ser Ile Phe Ala Leu Asn Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Gln Arg Glu Leu Val Ala Ala Ile His Ser Gly Gly Thr Thr Asn 
    290                 295                 300                 


Tyr Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
305                 310                 315                 320 


Ala Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
                325                 330                 335     


Ala Val Tyr Tyr Cys Asn Val Lys Asp Phe Gly Ala Ile Ile Tyr Asp 
            340                 345                 350         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Asp 
        355                 360                 365             


Asp Lys Met Ala His His Thr Leu Leu Leu Gly Ser Gly His Val Gly 
    370                 375                 380                 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn Ala Val Leu Gln Cys 
385                 390                 395                 400 


Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys Leu Arg Arg Asp Phe 
                405                 410                 415     


Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln Glu Leu Thr Glu Ala 
            420                 425                 430         


Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro Asp Ser Cys Glu Ala 
        435                 440                 445             


Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln Lys Tyr Val Pro Ser 
    450                 455                 460                 


Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu Lys Leu Leu 
465                 470                 475                 480 


Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg Gly Arg Arg Ala Pro 
                485                 490                 495     


Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro Pro Arg Arg Gly Gly 
            500                 505                 510         


Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp Asp Arg Ala Asn Leu 
        515                 520                 525             


Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser Lys Ile Val Asp Leu 
    530                 535                 540                 


Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys Gln Ala Cys Gly Tyr 
545                 550                 555                 560 


Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu Ser Leu Pro Ile Pro 
                565                 570                 575     


Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu Arg Asp Cys Phe Asn 
            580                 585                 590         


Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu Asn Ala Pro Val Cys 
        595                 600                 605             


Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys Lys Leu Thr Val Gln 
    610                 615                 620                 


Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn Arg Phe Ser Ala Ser 
625                 630                 635                 640 


Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val Asp Phe Pro Leu Gln 
                645                 650                 655     


Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys Ala Gly Ser Pro Val 
            660                 665                 670         


Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly Ser Val His Tyr Gly 
        675                 680                 685             


His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly Trp His Val Tyr Asn 
    690                 695                 700                 


Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln Val Ala Ser Ser Glu 
705                 710                 715                 720 


Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu Pro Pro Arg Cys Leu 
                725                 730                 735     


<210> 282
<211> 556
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 282
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu 
            260                 265                 270         


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser 
        275                 280                 285             


Ile Phe Ala Leu Asn Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Gln Arg Glu Leu Val Ala Ala Ile His Ser Gly Gly Thr Thr Asn Tyr 
305                 310                 315                 320 


Ala Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Ala 
                325                 330                 335     


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Asn Val Lys Asp Phe Gly Ala Ile Ile Tyr Asp Tyr 
        355                 360                 365             


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Thr Pro 
    370                 375                 380                 


Met Asp Ala Tyr Leu Arg Lys Leu Gly Leu Tyr Arg Lys Leu Val Ala 
385                 390                 395                 400 


Lys Asp Gly Ser Cys Leu Phe Arg Ala Val Ala Glu Gln Val Leu His 
                405                 410                 415     


Ser Gln Ser Arg His Val Glu Val Arg Met Ala Cys Ile His Tyr Leu 
            420                 425                 430         


Arg Glu Asn Arg Glu Lys Phe Glu Ala Phe Ile Glu Gly Ser Phe Glu 
        435                 440                 445             


Glu Tyr Leu Lys Arg Leu Glu Asn Pro Gln Glu Trp Val Gly Gln Val 
    450                 455                 460                 


Glu Ile Ser Ala Leu Ser Leu Met Tyr Arg Lys Asp Phe Ile Ile Tyr 
465                 470                 475                 480 


Arg Glu Pro Asn Val Ser Pro Ser Gln Val Thr Glu Asn Asn Phe Pro 
                485                 490                 495     


Glu Lys Val Leu Leu Cys Phe Ser Asn Gly Asn His Tyr Asp Ile Val 
            500                 505                 510         


Tyr Pro Ile Lys Tyr Lys Glu Ser Ser Ala Met Cys Gln Ser Leu Leu 
        515                 520                 525             


Tyr Glu Leu Leu Tyr Glu Lys Val Phe Lys Thr Asp Val Ser Lys Ile 
    530                 535                 540                 


Val Met Glu Leu Asp Thr Leu Glu Val Ala Asp Glu 
545                 550                 555     


<210> 283
<211> 789
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 283
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser 
        275                 280                 285             


Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala 
                325                 330                 335     


Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser 
        355                 360                 365             


Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser His His His His His His Glu Pro Glu Ala Pro Pro Ser Phe Ser 
385                 390                 395                 400 


Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg 
                405                 410                 415     


Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile 
            420                 425                 430         


Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser 
        435                 440                 445             


Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly 
    450                 455                 460                 


Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu 
465                 470                 475                 480 


Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg 
                485                 490                 495     


Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg 
            500                 505                 510         


Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro 
        515                 520                 525             


Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu 
    530                 535                 540                 


Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu 
545                 550                 555                 560 


Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg 
                565                 570                 575     


Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr 
            580                 585                 590         


Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala 
        595                 600                 605             


Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly 
    610                 615                 620                 


Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe 
625                 630                 635                 640 


His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val 
                645                 650                 655     


Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile 
            660                 665                 670         


Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys 
        675                 680                 685             


His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala 
    690                 695                 700                 


Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile 
705                 710                 715                 720 


Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val 
                725                 730                 735     


Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val 
            740                 745                 750         


Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu 
        755                 760                 765             


His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln 
    770                 775                 780                 


Ala Pro Leu Ala Gln 
785                 


<210> 284
<211> 590
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 284
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser 
        275                 280                 285             


Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala 
                325                 330                 335     


Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser 
        355                 360                 365             


Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser His His His His His His Glu Pro Glu Ala Asp Glu Lys Leu Ala 
385                 390                 395                 400 


Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg 
                405                 410                 415     


Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg 
            420                 425                 430         


Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser Leu His Arg Glu Leu 
        435                 440                 445             


Arg Glu Gln Thr Val His Tyr Ile Ala Asp His Leu Asp His Phe Ser 
    450                 455                 460                 


Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile Ile Ala Ala Ala Gln 
465                 470                 475                 480 


Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met Gly Gln Met 
                485                 490                 495     


Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro 
            500                 505                 510         


Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro Glu Asp Ser Leu Arg 
        515                 520                 525             


Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly His Tyr Asp Ala Val 
    530                 535                 540                 


Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln 
545                 550                 555                 560 


Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys Ser Met Ala 
                565                 570                 575     


Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys Ser 
            580                 585                 590 


<210> 285
<211> 848
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 285
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser 
        275                 280                 285             


Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala 
                325                 330                 335     


Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser 
        355                 360                 365             


Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser His His His His His His Glu Pro Glu Ala Leu Glu Val Asp Phe 
385                 390                 395                 400 


Lys Lys Leu Lys Gln Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu 
                405                 410                 415     


Phe Leu Asn Ala Cys Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile 
            420                 425                 430         


Glu Ala Tyr Lys Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala 
        435                 440                 445             


Asp Glu Val Arg Leu Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr 
    450                 455                 460                 


Thr Leu Val His Leu Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala 
465                 470                 475                 480 


Ile Leu Leu Thr Glu Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala 
                485                 490                 495     


Met Val Cys Pro Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala 
            500                 505                 510         


Ser Leu His Gln Arg Lys Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp 
        515                 520                 525             


Leu Val Thr Phe Thr Leu Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr 
    530                 535                 540                 


Val Gln Glu Lys Leu Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys 
545                 550                 555                 560 


Glu Leu Glu Glu Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala 
                565                 570                 575     


Thr Arg Leu Asp Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly 
            580                 585                 590         


Asp Cys Leu Leu Asp Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp 
        595                 600                 605             


Lys Asp Ser Val Leu Arg Lys Ala Leu His Asp Ser Leu His Asp Cys 
    610                 615                 620                 


Ser His Trp Phe Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser 
625                 630                 635                 640 


Gln Ser Phe Gly Leu His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu 
                645                 650                 655     


Asp Trp Ala Phe Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu 
            660                 665                 670         


Glu Gln Thr His Ile Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile 
        675                 680                 685             


Ile Val Tyr Gly Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu 
    690                 695                 700                 


Gly Tyr Thr Arg Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln 
705                 710                 715                 720 


Ser Phe Cys Trp Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His 
                725                 730                 735     


Phe Ser Ala Leu Val Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly 
            740                 745                 750         


Ala Gly Ala Asn Leu Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu 
        755                 760                 765             


Pro Leu Val Asp Ser Glu Arg Lys Leu Leu His Val His Phe Leu Ser 
    770                 775                 780                 


Ala Gln Glu Leu Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu 
785                 790                 795                 800 


Trp Leu Asp Cys Cys Val Thr Glu Gly Gly Val Leu Val Ala Met Gln 
                805                 810                 815     


Lys Ser Ser Arg Arg Arg Asn His Pro Leu Val Thr Gln Met Val Glu 
            820                 825                 830         


Lys Trp Leu Asp Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser 
        835                 840                 845             


<210> 286
<211> 765
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 286
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser 
        275                 280                 285             


Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala 
                325                 330                 335     


Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser 
        355                 360                 365             


Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser His His His His His His Glu Pro Glu Ala Ser Asp Asp Lys Met 
385                 390                 395                 400 


Ala His His Thr Leu Leu Leu Gly Ser Gly His Val Gly Leu Arg Asn 
                405                 410                 415     


Leu Gly Asn Thr Cys Phe Leu Asn Ala Val Leu Gln Cys Leu Ser Ser 
            420                 425                 430         


Thr Arg Pro Leu Arg Asp Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu 
        435                 440                 445             


Val Pro Gly Gly Gly Arg Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp 
    450                 455                 460                 


Val Ile Gly Ala Leu Trp His Pro Asp Ser Cys Glu Ala Val Asn Pro 
465                 470                 475                 480 


Thr Arg Phe Arg Ala Val Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly 
                485                 490                 495     


Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu Lys Leu Leu Met Glu Arg 
            500                 505                 510         


Leu His Leu Glu Ile Asn Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu 
        515                 520                 525             


Ala Asn Gly Pro Val Pro Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu 
    530                 535                 540                 


Glu Glu Pro Glu Leu Ser Asp Asp Asp Arg Ala Asn Leu Met Trp Lys 
545                 550                 555                 560 


Arg Tyr Leu Glu Arg Glu Asp Ser Lys Ile Val Asp Leu Phe Val Gly 
                565                 570                 575     


Gln Leu Lys Ser Cys Leu Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr 
            580                 585                 590         


Thr Phe Glu Val Phe Cys Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly 
        595                 600                 605             


Phe Ala Gly Gly Lys Val Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr 
    610                 615                 620                 


Lys Glu Glu Glu Leu Glu Ser Glu Asn Ala Pro Val Cys Asp Arg Cys 
625                 630                 635                 640 


Arg Gln Lys Thr Arg Ser Thr Lys Lys Leu Thr Val Gln Arg Phe Pro 
                645                 650                 655     


Arg Ile Leu Val Leu His Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser 
            660                 665                 670         


Ile Lys Lys Ser Ser Val Gly Val Asp Phe Pro Leu Gln Arg Leu Ser 
        675                 680                 685             


Leu Gly Asp Phe Ala Ser Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu 
    690                 695                 700                 


Tyr Ala Leu Cys Asn His Ser Gly Ser Val His Tyr Gly His Tyr Thr 
705                 710                 715                 720 


Ala Leu Cys Arg Cys Gln Thr Gly Trp His Val Tyr Asn Asp Ser Arg 
                725                 730                 735     


Val Ser Pro Val Ser Glu Asn Gln Val Ala Ser Ser Glu Gly Tyr Val 
            740                 745                 750         


Leu Phe Tyr Gln Leu Met Gln Glu Pro Pro Arg Cys Leu 
        755                 760                 765 


<210> 287
<211> 570
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 287
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Asp Ser 
        275                 280                 285             


Glu Arg Thr Ser Tyr Pro Met Gly Trp Phe Arg Arg Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ser Ile Thr Trp Ser Gly Ile Asp Pro Thr 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Ala Asp Arg Phe Thr Thr Ser Arg Asp Val Ala 
                325                 330                 335     


Asn Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys His Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala Arg Ala Pro Val Gly Gln Ser Ser Ser 
        355                 360                 365             


Pro Tyr Asp Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
    370                 375                 380                 


Ser His His His His His His Glu Pro Glu Ala Ala Thr Pro Met Asp 
385                 390                 395                 400 


Ala Tyr Leu Arg Lys Leu Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp 
                405                 410                 415     


Gly Ser Cys Leu Phe Arg Ala Val Ala Glu Gln Val Leu His Ser Gln 
            420                 425                 430         


Ser Arg His Val Glu Val Arg Met Ala Cys Ile His Tyr Leu Arg Glu 
        435                 440                 445             


Asn Arg Glu Lys Phe Glu Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr 
    450                 455                 460                 


Leu Lys Arg Leu Glu Asn Pro Gln Glu Trp Val Gly Gln Val Glu Ile 
465                 470                 475                 480 


Ser Ala Leu Ser Leu Met Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu 
                485                 490                 495     


Pro Asn Val Ser Pro Ser Gln Val Thr Glu Asn Asn Phe Pro Glu Lys 
            500                 505                 510         


Val Leu Leu Cys Phe Ser Asn Gly Asn His Tyr Asp Ile Val Tyr Pro 
        515                 520                 525             


Ile Lys Tyr Lys Glu Ser Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu 
    530                 535                 540                 


Leu Leu Tyr Glu Lys Val Phe Lys Thr Asp Val Ser Lys Ile Val Met 
545                 550                 555                 560 


Glu Leu Asp Thr Leu Glu Val Ala Asp Glu 
                565                 570 


<210> 288
<211> 780
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 288
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Pro Gly Ser Gln Val Gln Leu Gln Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Asp Phe Asp Asn Phe Asp Asp Tyr Ala Ile Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Gly Val Ser Cys Ile Asp 
305                 310                 315                 320 


Pro Ser Asp Gly Ser Thr Ile Tyr Ala Asp Ser Ala Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ser Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Ser Ala Trp Thr 
        355                 360                 365             


Leu Phe His Ser Asp Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro 
385                 390                 395                 400 


Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile 
                405                 410                 415     


Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly 
            420                 425                 430         


Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val 
        435                 440                 445             


Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met 
    450                 455                 460                 


Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp 
465                 470                 475                 480 


Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val 
                485                 490                 495     


Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro 
            500                 505                 510         


Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys 
        515                 520                 525             


Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp 
    530                 535                 540                 


Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu 
545                 550                 555                 560 


Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn 
                565                 570                 575     


Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp 
            580                 585                 590         


Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly 
        595                 600                 605             


Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val 
    610                 615                 620                 


Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu 
625                 630                 635                 640 


Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly 
                645                 650                 655     


Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu 
            660                 665                 670         


Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr 
        675                 680                 685             


Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn 
    690                 695                 700                 


Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu 
705                 710                 715                 720 


Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly 
                725                 730                 735     


Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu 
            740                 745                 750         


Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile 
        755                 760                 765             


Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
    770                 775                 780 


<210> 289
<211> 581
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 289
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Pro Gly Ser Gln Val Gln Leu Gln Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Asp Phe Asp Asn Phe Asp Asp Tyr Ala Ile Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Gly Val Ser Cys Ile Asp 
305                 310                 315                 320 


Pro Ser Asp Gly Ser Thr Ile Tyr Ala Asp Ser Ala Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ser Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Ser Ala Trp Thr 
        355                 360                 365             


Leu Phe His Ser Asp Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln 
385                 390                 395                 400 


Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro 
                405                 410                 415     


Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp 
            420                 425                 430         


Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala 
        435                 440                 445             


Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu 
    450                 455                 460                 


Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu 
465                 470                 475                 480 


Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr 
                485                 490                 495     


Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu 
            500                 505                 510         


Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser 
        515                 520                 525             


Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu 
    530                 535                 540                 


Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu 
545                 550                 555                 560 


Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu 
                565                 570                 575     


Gln Asn Ala Cys Ser 
            580     


<210> 290
<211> 839
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 290
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Pro Gly Ser Gln Val Gln Leu Gln Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Asp Phe Asp Asn Phe Asp Asp Tyr Ala Ile Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Gly Val Ser Cys Ile Asp 
305                 310                 315                 320 


Pro Ser Asp Gly Ser Thr Ile Tyr Ala Asp Ser Ala Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ser Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Ser Ala Trp Thr 
        355                 360                 365             


Leu Phe His Ser Asp Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys Asn Arg 
385                 390                 395                 400 


Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly Val Val 
                405                 410                 415     


Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly Gly Asp 
            420                 425                 430         


Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn Arg Pro 
        435                 440                 445             


Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile Arg Phe 
    450                 455                 460                 


Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser Gln Gln 
465                 470                 475                 480 


Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr Glu Gln 
                485                 490                 495     


Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly Asp Phe 
            500                 505                 510         


Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro Ala Asp 
        515                 520                 525             


Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp Glu Val 
    530                 535                 540                 


Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro Ile Ile 
545                 550                 555                 560 


Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu Tyr Ala 
                565                 570                 575     


Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val Leu Gln 
            580                 585                 590         


Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys Ala Leu 
        595                 600                 605             


His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg Trp Lys 
    610                 615                 620                 


Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe Ser Leu 
625                 630                 635                 640 


Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser Leu Ala 
                645                 650                 655     


Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val Leu Ala 
            660                 665                 670         


His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr Tyr Lys 
        675                 680                 685             


Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly Val Tyr 
    690                 695                 700                 


Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro Ile Ala 
705                 710                 715                 720 


Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met Glu Asn 
                725                 730                 735     


Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr Asp Asp 
            740                 745                 750         


Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg Lys Leu 
        755                 760                 765             


Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu Glu Gln 
    770                 775                 780                 


Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr Glu Gly 
785                 790                 795                 800 


Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn His Pro 
                805                 810                 815     


Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg Gln Ile 
            820                 825                 830         


Arg Pro Cys Thr Ser Leu Ser 
        835                 


<210> 291
<211> 756
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 291
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Pro Gly Ser Gln Val Gln Leu Gln Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Asp Phe Asp Asn Phe Asp Asp Tyr Ala Ile Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Gly Val Ser Cys Ile Asp 
305                 310                 315                 320 


Pro Ser Asp Gly Ser Thr Ile Tyr Ala Asp Ser Ala Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ser Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Ser Ala Trp Thr 
        355                 360                 365             


Leu Phe His Ser Asp Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly Ser 
385                 390                 395                 400 


Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn Ala 
                405                 410                 415     


Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys Leu 
            420                 425                 430         


Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln Glu 
        435                 440                 445             


Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro Asp 
    450                 455                 460                 


Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln Lys 
465                 470                 475                 480 


Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe 
                485                 490                 495     


Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg Gly 
            500                 505                 510         


Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro Pro 
        515                 520                 525             


Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp Asp 
    530                 535                 540                 


Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser Lys 
545                 550                 555                 560 


Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys Gln 
                565                 570                 575     


Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu Ser 
            580                 585                 590         


Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu Arg 
        595                 600                 605             


Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu Asn 
    610                 615                 620                 


Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys Lys 
625                 630                 635                 640 


Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn Arg 
                645                 650                 655     


Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val Asp 
            660                 665                 670         


Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys Ala 
        675                 680                 685             


Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly Ser 
    690                 695                 700                 


Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly Trp 
705                 710                 715                 720 


His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln Val 
                725                 730                 735     


Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu Pro 
            740                 745                 750         


Pro Arg Cys Leu 
        755     


<210> 292
<211> 561
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 292
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Pro Gly Ser Gln Val Gln Leu Gln Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Ala Gly Asp Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Phe Asp Phe Asp Asn Phe Asp Asp Tyr Ala Ile Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Gln Glu Arg Glu Gly Val Ser Cys Ile Asp 
305                 310                 315                 320 


Pro Ser Asp Gly Ser Thr Ile Tyr Ala Asp Ser Ala Lys Gly Arg Phe 
                325                 330                 335     


Thr Ile Ser Ser Asp Asn Ala Glu Asn Thr Val Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Val Cys Ser Ala Trp Thr 
        355                 360                 365             


Leu Phe His Ser Asp Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly Leu Tyr 
385                 390                 395                 400 


Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala Val Ala 
                405                 410                 415     


Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val Arg Met Ala 
            420                 425                 430         


Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala Phe Ile 
        435                 440                 445             


Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro Gln Glu 
    450                 455                 460                 


Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr Arg Lys 
465                 470                 475                 480 


Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln Val Thr 
                485                 490                 495     


Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn Gly Asn 
            500                 505                 510         


His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser Ala Met 
        515                 520                 525             


Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe Lys Thr 
    530                 535                 540                 


Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val Ala Asp 
545                 550                 555                 560 


Glu 
    


<210> 293
<211> 394
<212> PRT
<213> Homo sapiens

<400> 293
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 294
<211> 221
<212> PRT
<213> Homo sapiens

<400> 294
Met Glu Ala Gly Gly Phe Leu Asp Ser Leu Ile Tyr Gly Ala Cys Val 
1               5                   10                  15      


Val Phe Thr Leu Gly Met Phe Ser Ala Gly Leu Ser Asp Leu Arg His 
            20                  25                  30          


Met Arg Met Thr Arg Ser Val Asp Asn Val Gln Phe Leu Pro Phe Leu 
        35                  40                  45              


Thr Thr Glu Val Asn Asn Leu Gly Trp Leu Ser Tyr Gly Ala Leu Lys 
    50                  55                  60                  


Gly Asp Gly Ile Leu Ile Val Val Asn Thr Val Gly Ala Ala Leu Gln 
65                  70                  75                  80  


Thr Leu Tyr Ile Leu Ala Tyr Leu His Tyr Cys Pro Arg Lys Arg Val 
                85                  90                  95      


Val Leu Leu Gln Thr Ala Thr Leu Leu Gly Val Leu Leu Leu Gly Tyr 
            100                 105                 110         


Gly Tyr Phe Trp Leu Leu Val Pro Asn Pro Glu Ala Arg Leu Gln Gln 
        115                 120                 125             


Leu Gly Leu Phe Cys Ser Val Phe Thr Ile Ser Met Tyr Leu Ser Pro 
    130                 135                 140                 


Leu Ala Asp Leu Ala Lys Val Ile Gln Thr Lys Ser Thr Gln Cys Leu 
145                 150                 155                 160 


Ser Tyr Pro Leu Thr Ile Ala Thr Leu Leu Thr Ser Ala Ser Trp Cys 
                165                 170                 175     


Leu Tyr Gly Phe Arg Leu Arg Asp Pro Tyr Ile Met Val Ser Asn Phe 
            180                 185                 190         


Pro Gly Ile Val Thr Ser Phe Ile Arg Phe Trp Leu Phe Trp Lys Tyr 
        195                 200                 205             


Pro Gln Glu Gln Asp Arg Asn Tyr Trp Leu Leu Gln Thr 
    210                 215                 220     


<210> 295
<211> 79
<212> PRT
<213> Homo sapiens

<400> 295
Met Glu Leu Glu Ala Met Ser Arg Tyr Thr Ser Pro Val Asn Pro Ala 
1               5                   10                  15      


Val Phe Pro His Leu Thr Val Val Leu Leu Ala Ile Gly Met Phe Phe 
            20                  25                  30          


Thr Ala Trp Phe Phe Val Tyr Glu Val Thr Ser Thr Lys Tyr Thr Arg 
        35                  40                  45              


Asp Ile Tyr Lys Glu Leu Leu Ile Ser Leu Val Ala Ser Leu Phe Met 
    50                  55                  60                  


Gly Phe Gly Val Leu Phe Leu Leu Leu Trp Val Gly Ile Tyr Val 
65                  70                  75                  


<210> 296
<211> 695
<212> PRT
<213> Homo sapiens

<400> 296
Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Arg Phe Val Leu Thr Lys Leu Arg Val Ile Gln Lys Gly 
    50                  55                  60                  


Ala Phe Ser Gly Phe Gly Asp Leu Glu Lys Ile Glu Ile Ser Gln Asn 
65                  70                  75                  80  


Asp Val Leu Glu Val Ile Glu Ala Asp Val Phe Ser Asn Leu Pro Lys 
                85                  90                  95      


Leu His Glu Ile Arg Ile Glu Lys Ala Asn Asn Leu Leu Tyr Ile Asn 
            100                 105                 110         


Pro Glu Ala Phe Gln Asn Leu Pro Asn Leu Gln Tyr Leu Leu Ile Ser 
        115                 120                 125             


Asn Thr Gly Ile Lys His Leu Pro Asp Val His Lys Ile His Ser Leu 
    130                 135                 140                 


Gln Lys Val Leu Leu Asp Ile Gln Asp Asn Ile Asn Ile His Thr Ile 
145                 150                 155                 160 


Glu Arg Asn Ser Phe Val Gly Leu Ser Phe Glu Ser Val Ile Leu Trp 
                165                 170                 175     


Leu Asn Lys Asn Gly Ile Gln Glu Ile His Asn Cys Ala Phe Asn Gly 
            180                 185                 190         


Thr Gln Leu Asp Glu Leu Asn Leu Ser Asp Asn Asn Asn Leu Glu Glu 
        195                 200                 205             


Leu Pro Asn Asp Val Phe His Gly Ala Ser Gly Pro Val Ile Leu Asp 
    210                 215                 220                 


Ile Ser Arg Thr Arg Ile His Ser Leu Pro Ser Tyr Gly Leu Glu Asn 
225                 230                 235                 240 


Leu Lys Lys Leu Arg Ala Arg Ser Thr Tyr Asn Leu Lys Lys Leu Pro 
                245                 250                 255     


Thr Leu Glu Lys Leu Val Ala Leu Met Glu Ala Ser Leu Thr Tyr Pro 
            260                 265                 270         


Ser His Cys Cys Ala Phe Ala Asn Trp Arg Arg Gln Ile Ser Glu Leu 
        275                 280                 285             


His Pro Ile Cys Asn Lys Ser Ile Leu Arg Gln Glu Val Asp Tyr Met 
    290                 295                 300                 


Thr Gln Ala Arg Gly Gln Arg Ser Ser Leu Ala Glu Asp Asn Glu Ser 
305                 310                 315                 320 


Ser Tyr Ser Arg Gly Phe Asp Met Thr Tyr Thr Glu Phe Asp Tyr Asp 
                325                 330                 335     


Leu Cys Asn Glu Val Val Asp Val Thr Cys Ser Pro Lys Pro Asp Ala 
            340                 345                 350         


Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Asn Ile Leu Arg Val Leu 
        355                 360                 365             


Ile Trp Phe Ile Ser Ile Leu Ala Ile Thr Gly Asn Ile Ile Val Leu 
    370                 375                 380                 


Val Ile Leu Thr Thr Ser Gln Tyr Lys Leu Thr Val Pro Arg Phe Leu 
385                 390                 395                 400 


Met Cys Asn Leu Ala Phe Ala Asp Leu Cys Ile Gly Ile Tyr Leu Leu 
                405                 410                 415     


Leu Ile Ala Ser Val Asp Ile His Thr Lys Ser Gln Tyr His Asn Tyr 
            420                 425                 430         


Ala Ile Asp Trp Gln Thr Gly Ala Gly Cys Asp Ala Ala Gly Phe Phe 
        435                 440                 445             


Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu Thr Ala Ile Thr 
    450                 455                 460                 


Leu Glu Arg Trp His Thr Ile Thr His Ala Met Gln Leu Asp Cys Lys 
465                 470                 475                 480 


Val Gln Leu Arg His Ala Ala Ser Val Met Val Met Gly Trp Ile Phe 
                485                 490                 495     


Ala Phe Ala Ala Ala Leu Phe Pro Ile Phe Gly Ile Ser Ser Tyr Met 
            500                 505                 510         


Lys Val Ser Ile Cys Leu Pro Met Asp Ile Asp Ser Pro Leu Ser Gln 
        515                 520                 525             


Leu Tyr Val Met Ser Leu Leu Val Leu Asn Val Leu Ala Phe Val Val 
    530                 535                 540                 


Ile Cys Gly Cys Tyr Ile His Ile Tyr Leu Thr Val Arg Asn Pro Asn 
545                 550                 555                 560 


Ile Val Ser Ser Ser Ser Asp Thr Arg Ile Ala Lys Arg Met Ala Met 
                565                 570                 575     


Leu Ile Phe Thr Asp Phe Leu Cys Met Ala Pro Ile Ser Phe Phe Ala 
            580                 585                 590         


Ile Ser Ala Ser Leu Lys Val Pro Leu Ile Thr Val Ser Lys Ala Lys 
        595                 600                 605             


Ile Leu Leu Val Leu Phe His Pro Ile Asn Ser Cys Ala Asn Pro Phe 
    610                 615                 620                 


Leu Tyr Ala Ile Phe Thr Lys Asn Phe Arg Arg Asp Phe Phe Ile Leu 
625                 630                 635                 640 


Leu Ser Lys Cys Gly Cys Tyr Glu Met Gln Ala Gln Ile Tyr Arg Thr 
                645                 650                 655     


Glu Thr Ser Ser Thr Val His Asn Thr His Pro Arg Asn Gly His Cys 
            660                 665                 670         


Ser Ser Ala Pro Arg Val Thr Asn Gly Ser Thr Tyr Ile Leu Val Pro 
        675                 680                 685             


Leu Ser His Leu Ala Gln Asn 
    690                 695 


<210> 297
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 297
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 298
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 298
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 299
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 299
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 300
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 300
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 301
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 301
Gly Gly Gly Gly Ser 
1               5   


<210> 302
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 302
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 303
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 303
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210> 304
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 304
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210> 305
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 305
Ser Gly Gly Gly Gly 
1               5   


<210> 306
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 306
Gly Gly Ser Gly Gly 
1               5   


<210> 307
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 307
Ala His Phe Lys Ile Ser Gly Glu Lys Arg Pro Ser Thr Asp Pro Gly 
1               5                   10                  15      


Lys Lys Ala Lys Asn Pro Lys Lys Lys Lys Lys Lys Asp Pro 
            20                  25                  30  


<210> 308
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 308
Ala His Arg Ala Lys Lys Met Ser Lys Thr His Ala 
1               5                   10          


<210> 309
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 309
Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
1               5                   10                  


<210> 310
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 310
Cys Thr Lys Arg Pro Arg Trp 
1               5           


<210> 311
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 311
Asp Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10                  15      


<210> 312
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 312
Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile Tyr Ala 
1               5                   10                  15  


<210> 313
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 313
Glu Glu Gln Leu Arg Arg Arg Lys Asn Ser Arg Leu Asn Asn Thr Gly 
1               5                   10                  15      


<210> 314
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 314
Glu Val Leu Lys Val Ile Arg Thr Gly Lys Arg Lys Lys Lys Ala Trp 
1               5                   10                  15      


Lys Arg Met Val Thr Lys Val Cys 
            20                  


<210> 315
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 315
His His His His His His His His His His His His Gln Pro His 
1               5                   10                  15  


<210> 316
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 316
His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210> 317
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 317
His Lys Arg Thr Lys Lys Asn Leu Ser 
1               5                   


<210> 318
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 318
Ile Ile Asn Gly Arg Lys Leu Lys Leu Lys Lys Ser Arg Arg Arg Ser 
1               5                   10                  15      


Ser Gln Thr Ser Asn Asn Ser Phe Thr Ser Arg Arg Ser 
            20                  25                  


<210> 319
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 319
Lys Ala Glu Gln Glu Arg Arg Lys 
1               5               


<210> 320
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 320
Lys Glu Lys Arg Lys Arg Arg Glu Glu Leu Phe Ile Glu Gln Lys Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 321
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 321
Lys Lys Gly Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro 
1               5                   10                  


<210> 322
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 322
Lys Lys Gly Pro Ser Val Gln Lys Arg Lys Lys Thr Asn Leu Ser 
1               5                   10                  15  


<210> 323
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 323
Lys Lys Lys Thr Val Ile Asn Asp Leu Leu His Tyr Lys Lys Glu Lys 
1               5                   10                  15      


<210> 324
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 324
Lys Lys Asn Gly Gly Lys Gly Lys Asn Lys Pro Ser Ala Lys Ile Lys 
1               5                   10                  15      


Lys 
    


<210> 325
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 325
Lys Lys Pro Lys Trp Asp Asp Phe Lys Lys Lys Lys Lys 
1               5                   10              


<210> 326
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 326
Lys Lys Arg Lys Lys Asp Asn Leu Ser 
1               5                   


<210> 327
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 327
Lys Lys Arg Arg Lys Arg Arg Arg Lys 
1               5                   


<210> 328
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 328
Lys Lys Arg Arg Arg Arg Ala Arg Lys 
1               5                   


<210> 329
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 329
Lys Lys Ser Lys Arg Gly Arg 
1               5           


<210> 330
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 330
Lys Lys Ser Arg Lys Arg Gly Ser 
1               5               


<210> 331
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 331
Lys Lys Ser Thr Ala Leu Ser Arg Glu Leu Gly Lys Ile Met Arg Arg 
1               5                   10                  15      


Arg 
    


<210> 332
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 332
Lys Lys Ser Tyr Gln Asp Pro Glu Ile Ile Ala His Ser Arg Pro Arg 
1               5                   10                  15      


Lys 
    


<210> 333
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 333
Lys Lys Thr Gly Lys Asn Arg Lys Leu Lys Ser Lys Arg Val Lys Thr 
1               5                   10                  15      


Arg 
    


<210> 334
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 334
Lys Lys Val Ser Ile Ala Gly Gln Ser Gly Lys Leu Trp Arg Trp Lys 
1               5                   10                  15      


Arg 
    


<210> 335
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 335
Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210> 336
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 336
Lys Asn Lys Lys Arg Lys 
1               5       


<210> 337
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 337
Lys Pro Lys Lys Lys Arg 
1               5       


<210> 338
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 338
Lys Arg Ala Met Lys Asp Asp Ser His Gly Asn Ser Thr Ser Pro Lys 
1               5                   10                  15      


Arg Arg Lys 
            


<210> 339
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 339
Lys Arg Ala Asn Ser Asn Leu Val Ala Ala Tyr Glu Lys Ala Lys Lys 
1               5                   10                  15      


Lys 
    


<210> 340
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 340
Lys Arg Ala Ser Glu Asp Thr Thr Ser Gly Ser Pro Pro Lys Lys Ser 
1               5                   10                  15      


Ser Ala Gly Pro Lys Arg 
            20          


<210> 341
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 341
Lys Arg Phe Lys Arg Arg Trp Met Val Arg Lys Met Lys Thr Lys Lys 
1               5                   10                  15      


<210> 342
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 342
Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 343
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 343
Lys Arg Gly Asn Ser Ser Ile Gly Pro Asn Asp Leu Ser Lys Arg Lys 
1               5                   10                  15      


Gln Arg Lys Lys 
            20  


<210> 344
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 344
Lys Arg Ile His Ser Val Ser Leu Ser Gln Ser Gln Ile Asp Pro Ser 
1               5                   10                  15      


Lys Lys Val Lys Arg Ala Lys 
            20              


<210> 345
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 345
Lys Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys Arg Lys Lys 
1               5                   10                  15  


<210> 346
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 346
Lys Arg Arg Arg Arg Arg Arg Arg Glu Lys Arg Lys Arg 
1               5                   10              


<210> 347
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 347
Lys Arg Ser Asn Asp Arg Thr Tyr Ser Pro Glu Glu Glu Lys Gln Arg 
1               5                   10                  15      


Arg Ala 
        


<210> 348
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 348
Lys Arg Thr Val Ala Thr Asn Gly Asp Ala Ser Gly Ala His Arg Ala 
1               5                   10                  15      


Lys Lys Met Ser Lys 
            20      


<210> 349
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 349
Lys Arg Val Tyr Asn Lys Gly Glu Asp Glu Gln Glu His Leu Pro Lys 
1               5                   10                  15      


Gly Lys Lys Arg 
            20  


<210> 350
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 350
Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn Ser 
1               5                   10                  15      


Asn Lys 
        


<210> 351
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 351
Lys Val Asn Phe Leu Asp Met Ser Leu Asp Asp Ile Ile Ile Tyr Lys 
1               5                   10                  15      


Glu Leu Glu 
            


<210> 352
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 352
Lys Val Gln His Arg Ile Ala Lys Lys Thr Thr Arg Arg Arg Arg 
1               5                   10                  15  


<210> 353
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 353
Leu Ser Pro Ser Leu Ser Pro Leu 
1               5               


<210> 354
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 354
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210> 355
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 355
Met Pro Gln Asn Glu Tyr Ile Glu Leu His Arg Lys Arg Tyr Gly Tyr 
1               5                   10                  15      


Arg Leu Asp Tyr His Glu Lys Lys Arg Lys Lys Glu Ser Arg Glu Ala 
            20                  25                  30          


His Glu Arg Ser Lys Lys Ala Lys Lys Met Ile Gly Leu Lys Ala Lys 
        35                  40                  45              


Leu Tyr His Lys 
    50          


<210> 356
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 356
Met Val Gln Leu Arg Pro Arg Ala Ser Arg 
1               5                   10  


<210> 357
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 357
Asn Asn Lys Leu Leu Ala Lys Arg Arg Lys Gly Gly Ala Ser Pro Lys 
1               5                   10                  15      


Asp Asp Pro Met Asp Asp Ile Lys 
            20                  


<210> 358
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 358
Asn Tyr Lys Arg Pro Met Asp Gly Thr Tyr Gly Pro Pro Ala Lys Arg 
1               5                   10                  15      


His Glu Gly Glu 
            20  


<210> 359
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 359
Pro Asp Thr Lys Arg Ala Lys Leu Asp Ser Ser Glu Thr Thr Met Val 
1               5                   10                  15      


Lys Lys Lys 
            


<210> 360
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 360
Pro Glu Lys Arg Thr Lys Ile 
1               5           


<210> 361
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 361
Pro Gly Gly Arg Gly Lys Lys Lys 
1               5               


<210> 362
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 362
Pro Gly Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg 
1               5                   10                  15      


Pro Tyr 
        


<210> 363
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 363
Pro Lys Lys Gly Asp Lys Tyr Asp Lys Thr Asp 
1               5                   10      


<210> 364
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 364
Pro Lys Lys Lys Ser Arg Lys 
1               5           


<210> 365
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 365
Pro Lys Lys Asn Lys Pro Glu 
1               5           


<210> 366
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 366
Pro Lys Lys Arg Ala Lys Val 
1               5           


<210> 367
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 367
Pro Lys Pro Lys Lys Leu Lys Val Glu 
1               5                   


<210> 368
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 368
Pro Lys Arg Gly Arg Gly Arg 
1               5           


<210> 369
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 369
Pro Lys Arg Arg Leu Val Asp Asp Ala 
1               5                   


<210> 370
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 370
Pro Lys Arg Arg Arg Thr Tyr 
1               5           


<210> 371
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 371
Pro Leu Phe Lys Arg Arg 
1               5       


<210> 372
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 372
Pro Leu Arg Lys Ala Lys Arg 
1               5           


<210> 373
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 373
Pro Pro Ala Lys Arg Lys Cys Ile Phe 
1               5                   


<210> 374
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 374
Pro Pro Ala Arg Arg Arg Arg Leu 
1               5               


<210> 375
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 375
Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210> 376
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 376
Pro Pro Asn Lys Arg Met Lys Val Lys His 
1               5                   10  


<210> 377
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 377
Pro Pro Arg Ile Tyr Pro Gln Leu Pro Ser Ala Pro Thr 
1               5                   10              


<210> 378
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 378
Pro Gln Arg Ser Pro Phe Pro Lys Ser Ser Val Lys Arg 
1               5                   10              


<210> 379
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 379
Pro Arg Pro Arg Lys Val Pro Arg 
1               5               


<210> 380
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 380
Pro Arg Arg Arg Val Gln Arg Lys Arg 
1               5                   


<210> 381
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 381
Pro Arg Arg Val Arg Leu Lys 
1               5           


<210> 382
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 382
Pro Ser Arg Lys Arg Pro Arg 
1               5           


<210> 383
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 383
Pro Ser Ser Lys Lys Arg Lys Val 
1               5               


<210> 384
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 384
Pro Thr Lys Lys Arg Val Lys 
1               5           


<210> 385
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 385
Gln Arg Pro Gly Pro Tyr Asp Arg Pro 
1               5                   


<210> 386
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 386
Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210> 387
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 387
Arg Lys Ala Gly Lys Gly Gly Gly Gly His Lys Thr Thr Lys Lys Arg 
1               5                   10                  15      


Ser Ala Lys Asp Glu Lys Val Pro 
            20                  


<210> 388
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 388
Arg Lys Ile Lys Leu Lys Arg Ala Lys 
1               5                   


<210> 389
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 389
Arg Lys Ile Lys Arg Lys Arg Ala Lys 
1               5                   


<210> 390
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 390
Arg Lys Lys Glu Ala Pro Gly Pro Arg Glu Glu Leu Arg Ser Arg Gly 
1               5                   10                  15      


Arg 
    


<210> 391
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 391
Arg Lys Lys Arg Lys Gly Lys 
1               5           


<210> 392
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 392
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210> 393
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 393
Arg Lys Lys Ser Ile Pro Leu Ser Ile Lys Asn Leu Lys Arg Lys His 
1               5                   10                  15      


Lys Arg Lys Lys Asn Lys Ile Thr Arg 
            20                  25  


<210> 394
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 394
Arg Lys Leu Val Lys Pro Lys Asn Thr Lys Met Lys Thr Lys Leu Arg 
1               5                   10                  15      


Thr Asn Pro Tyr 
            20  


<210> 395
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 395
Arg Lys Arg Leu Ile Leu Ser Asp Lys Gly Gln Leu Asp Trp Lys Lys 
1               5                   10                  15      


<210> 396
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 396
Arg Lys Arg Leu Lys Ser Lys 
1               5           


<210> 397
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 397
Arg Lys Arg Arg Val Arg Asp Asn Met 
1               5                   


<210> 398
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 398
Arg Lys Arg Ser Pro Lys Asp Lys Lys Glu Lys Asp Leu Asp Gly Ala 
1               5                   10                  15      


Gly Lys Arg Arg Lys Thr 
            20          


<210> 399
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 399
Arg Lys Arg Thr Pro Arg Val Asp Gly Gln Thr Gly Glu Asn Asp Met 
1               5                   10                  15      


Asn Lys Arg Arg Arg Lys 
            20          


<210> 400
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 400
Arg Leu Pro Val Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210> 401
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 401
Arg Leu Arg Phe Arg Lys Pro Lys Ser Lys 
1               5                   10  


<210> 402
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 402
Arg Gln Gln Arg Lys Arg 
1               5       


<210> 403
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 403
Arg Arg Asp Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 404
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 404
Arg Arg Asp Arg Ala Lys Leu Arg 
1               5               


<210> 405
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 405
Arg Arg Gly Asp Gly Arg Arg Arg 
1               5               


<210> 406
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 406
Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln 
1               5                   10      


<210> 407
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 407
Arg Arg Lys Lys Arg Arg 
1               5       


<210> 408
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 408
Arg Arg Lys Arg Ser Lys Ser Glu Asp Met Asp Ser Val Glu Ser Lys 
1               5                   10                  15      


Arg Arg Arg 
            


<210> 409
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 409
Arg Arg Lys Arg Ser Arg 
1               5       


<210> 410
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 410
Arg Arg Pro Lys Gly Lys Thr Leu Gln Lys Arg Lys Pro Lys 
1               5                   10                  


<210> 411
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 411
Arg Arg Arg Gly Phe Glu Arg Phe Gly Pro Asp Asn Met Gly Arg Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 412
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 412
Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys 
1               5                   10                  15  


<210> 413
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 413
Arg Arg Arg Lys Arg Arg Asn Leu Ser 
1               5                   


<210> 414
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 414
Arg Arg Arg Gln Lys Gln Lys Gly Gly Ala Ser Arg Arg Arg 
1               5                   10                  


<210> 415
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 415
Arg Arg Arg Arg Glu Gly Pro Arg Ala Arg Arg Arg Arg 
1               5                   10              


<210> 416
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 416
Arg Arg Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser 
1               5                   10                  15      


Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe 
            20                  25                  30          


His Lys Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly 
        35                  40                  45              


Arg Met Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu 
    50                  55                  60      


<210> 417
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 417
Arg Arg Val Pro Gln Arg Lys Glu Val Ser Arg Cys Arg Lys Cys Arg 
1               5                   10                  15      


Lys 
    


<210> 418
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 418
Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu Leu 
1               5                   10                  15      


Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg Pro 
            20                  25                  30          


<210> 419
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 419
Arg Val Val Lys Leu Arg Ile Ala Pro 
1               5                   


<210> 420
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 420
Arg Val Val Arg Arg Arg 
1               5       


<210> 421
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 421
Ser Lys Arg Lys Thr Lys Ile Ser Arg Lys Thr Arg 
1               5                   10          


<210> 422
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 422
Ser Tyr Val Lys Thr Val Pro Asn Arg Thr Arg Thr Tyr Ile Lys Leu 
1               5                   10                  15      


<210> 423
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 423
Thr Gly Lys Asn Glu Ala Lys Lys Arg Lys Ile Ala 
1               5                   10          


<210> 424
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 424
Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser Val Ser Cys Pro Val Ile 
1               5                   10                  15      


Pro Ala Ser Thr Asp Glu Ser Pro Gly Ser Ala Leu Asn Ile 
            20                  25                  30  


<210> 425
<211> 170
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 425
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
            20                  25                  30          


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
        35                  40                  45              


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
145                 150                 155                 160 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
                165                 170 


<210> 426
<211> 554
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 426
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys 
545                 550                 


<210> 427
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 427
Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
1               5                   10                  15  


<210> 428
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 428
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 429
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 429
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 430
<211> 1657
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 430
Met Gly Arg Val Gly Tyr Trp Thr Leu Leu Val Leu Pro Ala Leu Leu 
1               5                   10                  15      


Val Trp Arg Gly Pro Ala Pro Ser Ala Ala Ala Glu Lys Gly Pro Pro 
            20                  25                  30          


Ala Leu Asn Ile Ala Val Met Leu Gly His Ser His Asp Val Thr Glu 
        35                  40                  45              


Arg Glu Leu Arg Thr Leu Trp Gly Pro Glu Gln Ala Ala Gly Leu Pro 
    50                  55                  60                  


Leu Asp Val Asn Val Val Ala Leu Leu Met Asn Arg Thr Asp Pro Lys 
65                  70                  75                  80  


Ser Leu Ile Thr His Val Cys Asp Leu Met Ser Gly Ala Arg Ile His 
                85                  90                  95      


Gly Leu Val Phe Gly Asp Asp Thr Asp Gln Glu Ala Val Ala Gln Met 
            100                 105                 110         


Leu Asp Phe Ile Ser Ser His Thr Phe Val Pro Ile Leu Gly Ile His 
        115                 120                 125             


Gly Gly Ala Ser Met Ile Met Ala Asp Lys Asp Pro Thr Ser Thr Phe 
    130                 135                 140                 


Phe Gln Phe Gly Ala Ser Ile Gln Gln Gln Ala Thr Val Met Leu Lys 
145                 150                 155                 160 


Ile Met Gln Asp Tyr Asp Trp His Val Phe Ser Leu Val Thr Thr Ile 
                165                 170                 175     


Phe Pro Gly Tyr Arg Glu Phe Ile Ser Phe Val Lys Thr Thr Val Asp 
            180                 185                 190         


Asn Ser Phe Val Gly Trp Asp Met Gln Asn Val Ile Thr Leu Asp Thr 
        195                 200                 205             


Ser Phe Glu Asp Ala Lys Thr Gln Val Gln Leu Lys Lys Ile His Ser 
    210                 215                 220                 


Ser Val Ile Leu Leu Tyr Cys Ser Lys Asp Glu Ala Val Leu Ile Leu 
225                 230                 235                 240 


Ser Glu Ala Arg Ser Leu Gly Leu Thr Gly Tyr Asp Phe Phe Trp Ile 
                245                 250                 255     


Val Pro Ser Leu Val Ser Gly Asn Thr Glu Leu Ile Pro Lys Glu Phe 
            260                 265                 270         


Pro Ser Gly Leu Ile Ser Val Ser Tyr Asp Asp Trp Asp Tyr Ser Leu 
        275                 280                 285             


Glu Ala Arg Val Arg Asp Gly Ile Gly Ile Leu Thr Thr Ala Ala Ser 
    290                 295                 300                 


Ser Met Leu Glu Lys Phe Ser Tyr Ile Pro Glu Ala Lys Ala Ser Cys 
305                 310                 315                 320 


Tyr Gly Gln Met Glu Arg Pro Glu Val Pro Met His Thr Leu His Pro 
                325                 330                 335     


Phe Met Val Asn Val Thr Trp Asp Gly Lys Asp Leu Ser Phe Thr Glu 
            340                 345                 350         


Glu Gly Tyr Gln Val His Pro Arg Leu Val Val Ile Val Leu Asn Lys 
        355                 360                 365             


Asp Arg Glu Trp Glu Lys Val Gly Lys Trp Glu Asn His Thr Leu Ser 
    370                 375                 380                 


Leu Arg His Ala Val Trp Pro Arg Tyr Lys Ser Phe Ser Asp Cys Glu 
385                 390                 395                 400 


Pro Asp Asp Asn His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Asp Ile Asp Pro Leu Thr Glu Thr Cys Val Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Arg Lys Phe Val Lys Ile Asn Asn Ser Thr Asn Glu 
        435                 440                 445             


Gly Met Asn Val Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile Leu 
    450                 455                 460                 


Lys Lys Leu Ser Arg Thr Val Lys Phe Thr Tyr Asp Leu Tyr Leu Val 
465                 470                 475                 480 


Thr Asn Gly Lys His Gly Lys Lys Val Asn Asn Val Trp Asn Gly Met 
                485                 490                 495     


Ile Gly Glu Val Val Tyr Gln Arg Ala Val Met Ala Val Gly Ser Leu 
            500                 505                 510         


Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro Phe 
        515                 520                 525             


Val Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr Val 
    530                 535                 540                 


Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Ser Val Trp Val Met 
545                 550                 555                 560 


Met Phe Val Met Leu Leu Ile Val Ser Ala Ile Ala Val Phe Val Phe 
                565                 570                 575     


Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Asn Leu Ala Lys Gly Lys 
            580                 585                 590         


Ala Pro His Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu Leu 
        595                 600                 605             


Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys Gly 
    610                 615                 620                 


Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val Ile 
625                 630                 635                 640 


Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln Glu 
                645                 650                 655     


Glu Phe Val Asp Gln Val Thr Gly Leu Ser Asp Lys Lys Phe Gln Arg 
            660                 665                 670         


Pro His Asp Tyr Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn Gly 
        675                 680                 685             


Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Pro Tyr Met His Gln Tyr 
    690                 695                 700                 


Met Thr Lys Phe Asn Gln Lys Gly Val Glu Asp Ala Leu Val Ser Leu 
705                 710                 715                 720 


Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu Asn 
                725                 730                 735     


Tyr Lys Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly Ser 
            740                 745                 750         


Gly Tyr Ile Phe Ala Thr Thr Gly Tyr Gly Ile Ala Leu Gln Lys Gly 
        755                 760                 765             


Ser Pro Trp Lys Arg Gln Ile Asp Leu Ala Leu Leu Gln Phe Val Gly 
    770                 775                 780                 


Asp Gly Glu Met Glu Glu Leu Glu Thr Leu Trp Leu Thr Gly Ile Cys 
785                 790                 795                 800 


His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp Asn 
                805                 810                 815     


Met Ala Gly Val Phe Tyr Met Leu Ala Ala Ala Met Ala Leu Ser Leu 
            820                 825                 830         


Ile Thr Phe Ile Trp Glu His Leu Phe Tyr Trp Lys Leu Arg Phe Cys 
        835                 840                 845             


Phe Thr Gly Val Cys Ser Asp Arg Pro Gly Leu Leu Phe Ser Ile Ser 
    850                 855                 860                 


Arg Gly Ile Tyr Ser Cys Ile His Gly Val His Ile Glu Glu Lys Lys 
865                 870                 875                 880 


Lys Ser Pro Asp Phe Asn Leu Thr Gly Ser Gln Ser Asn Met Leu Lys 
                885                 890                 895     


Leu Leu Arg Ser Ala Lys Asn Ile Ser Ser Met Ser Asn Met Asn Ser 
            900                 905                 910         


Ser Arg Met Asp Ser Pro Lys Arg Ala Ala Asp Phe Ile Gln Arg Gly 
        915                 920                 925             


Ser Leu Ile Met Asp Met Val Ser Asp Lys Gly Asn Leu Met Tyr Ser 
    930                 935                 940                 


Asp Asn Arg Ser Phe Gln Gly Lys Glu Ser Ile Phe Gly Asp Asn Met 
945                 950                 955                 960 


Asn Glu Leu Gln Thr Phe Val Ala Asn Arg Gln Lys Asp Asn Leu Asn 
                965                 970                 975     


Asn Tyr Val Phe Gln Gly Gln His Pro Leu Thr Leu Asn Glu Ser Asn 
            980                 985                 990         


Pro Asn Thr Val Glu Val Ala Val  Ser Thr Glu Ser Lys  Ala Asn Ser 
        995                 1000                 1005             


Arg Pro  Arg Gln Leu Trp Lys  Lys Ser Val Asp Ser  Ile Arg Gln 
    1010                 1015                 1020             


Asp Ser  Leu Ser Gln Asn Pro  Val Ser Gln Arg Asp  Glu Ala Thr 
    1025                 1030                 1035             


Ala Glu  Asn Arg Thr His Ser  Leu Lys Ser Pro Arg  Tyr Leu Pro 
    1040                 1045                 1050             


Glu Glu  Met Ala His Ser Asp  Ile Ser Glu Thr Ser  Asn Arg Ala 
    1055                 1060                 1065             


Thr Cys  His Arg Glu Pro Asp  Asn Ser Lys Asn His  Lys Thr Lys 
    1070                 1075                 1080             


Asp Asn  Phe Lys Arg Ser Val  Ala Ser Lys Tyr Pro  Lys Asp Cys 
    1085                 1090                 1095             


Ser Glu  Val Glu Arg Thr Tyr  Leu Lys Thr Lys Ser  Ser Ser Pro 
    1100                 1105                 1110             


Arg Asp  Lys Ile Tyr Thr Ile  Asp Gly Glu Lys Glu  Pro Gly Phe 
    1115                 1120                 1125             


His Leu  Asp Pro Pro Gln Phe  Val Glu Asn Val Thr  Leu Pro Glu 
    1130                 1135                 1140             


Asn Val  Asp Phe Pro Asp Pro  Tyr Gln Asp Pro Ser  Glu Asn Phe 
    1145                 1150                 1155             


Arg Lys  Gly Asp Ser Thr Leu  Pro Met Asn Arg Asn  Pro Leu His 
    1160                 1165                 1170             


Asn Glu  Glu Gly Leu Ser Asn  Asn Asp Gln Tyr Lys  Leu Tyr Ser 
    1175                 1180                 1185             


Lys His  Phe Thr Leu Lys Asp  Lys Gly Ser Pro His  Ser Glu Thr 
    1190                 1195                 1200             


Ser Glu  Arg Tyr Arg Gln Asn  Ser Thr His Cys Arg  Ser Cys Leu 
    1205                 1210                 1215             


Ser Asn  Met Pro Thr Tyr Ser  Gly His Phe Thr Met  Arg Ser Pro 
    1220                 1225                 1230             


Phe Lys  Cys Asp Ala Cys Leu  Arg Met Gly Asn Leu  Tyr Asp Ile 
    1235                 1240                 1245             


Asp Glu  Asp Gln Met Leu Gln  Glu Thr Gly Asn Pro  Ala Thr Gly 
    1250                 1255                 1260             


Glu Gln  Val Tyr Gln Gln Asp  Trp Ala Gln Asn Asn  Ala Leu Gln 
    1265                 1270                 1275             


Leu Gln  Lys Asn Lys Leu Arg  Ile Ser Arg Gln His  Ser Tyr Asp 
    1280                 1285                 1290             


Asn Ile  Val Asp Lys Pro Arg  Glu Leu Asp Leu Ser  Arg Pro Ser 
    1295                 1300                 1305             


Arg Ser  Ile Ser Leu Lys Asp  Arg Glu Arg Leu Leu  Glu Gly Asn 
    1310                 1315                 1320             


Phe Tyr  Gly Ser Leu Phe Ser  Val Pro Ser Ser Lys  Leu Ser Gly 
    1325                 1330                 1335             


Lys Lys  Ser Ser Leu Phe Pro  Gln Gly Leu Glu Asp  Ser Lys Arg 
    1340                 1345                 1350             


Ser Lys  Ser Leu Leu Pro Asp  His Thr Ser Asp Asn  Pro Phe Leu 
    1355                 1360                 1365             


His Ser  His Arg Asp Asp Gln  Arg Leu Val Ile Gly  Arg Cys Pro 
    1370                 1375                 1380             


Ser Asp  Pro Tyr Lys His Ser  Leu Pro Ser Gln Ala  Val Asn Asp 
    1385                 1390                 1395             


Ser Tyr  Leu Arg Ser Ser Leu  Arg Ser Thr Ala Ser  Tyr Cys Ser 
    1400                 1405                 1410             


Arg Asp  Ser Arg Gly His Asn  Asp Val Tyr Ile Ser  Glu His Val 
    1415                 1420                 1425             


Met Pro  Tyr Ala Ala Asn Lys  Asn Asn Met Tyr Ser  Thr Pro Arg 
    1430                 1435                 1440             


Val Leu  Asn Ser Cys Ser Asn  Arg Arg Val Tyr Lys  Lys Met Pro 
    1445                 1450                 1455             


Ser Ile  Glu Ser Asp Val Lys  Val Pro Val Phe Thr  Leu Glu Asp 
    1460                 1465                 1470             


Phe Val  Gly Asp Trp Arg Gln  Thr Ala Gly Tyr Asn  Leu Asp Gln 
    1475                 1480                 1485             


Val Leu  Glu Gln Gly Gly Val  Ser Ser Leu Phe Gln  Asn Leu Gly 
    1490                 1495                 1500             


Val Ser  Val Thr Pro Ile Gln  Arg Ile Val Leu Ser  Gly Glu Asn 
    1505                 1510                 1515             


Gly Leu  Lys Ile Asp Ile His  Val Ile Ile Pro Tyr  Glu Gly Leu 
    1520                 1525                 1530             


Ser Gly  Asp Gln Met Gly Gln  Ile Glu Lys Ile Phe  Lys Val Val 
    1535                 1540                 1545             


Tyr Pro  Val Asp Asp His His  Phe Lys Val Ile Leu  His Tyr Gly 
    1550                 1555                 1560             


Thr Leu  Val Ile Asp Gly Val  Thr Pro Asn Met Ile  Asp Tyr Phe 
    1565                 1570                 1575             


Gly Arg  Pro Tyr Glu Gly Ile  Ala Val Phe Asp Gly  Lys Lys Ile 
    1580                 1585                 1590             


Thr Val  Thr Gly Thr Leu Trp  Asn Gly Asn Lys Ile  Ile Asp Glu 
    1595                 1600                 1605             


Arg Leu  Ile Asn Pro Asp Gly  Ser Leu Leu Phe Arg  Val Thr Ile 
    1610                 1615                 1620             


Asn Gly  Val Thr Gly Trp Arg  Leu Cys Glu Arg Ile  Leu Ala Gly 
    1625                 1630                 1635             


Gly Gly  Gly Ser Pro Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg 
    1640                 1645                 1650             


Leu Thr  Glu Pro 
    1655         


<210> 431
<211> 685
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 431
Met Glu Pro Ser Ser Lys Lys Leu Thr Gly Arg Leu Met Leu Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Leu Gly Ser Leu Gln Phe Gly Tyr Asn Thr Gly Val 
            20                  25                  30          


Ile Asn Ala Pro Gln Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp 
        35                  40                  45              


Val His Arg Tyr Gly Glu Ser Ile Leu Pro Thr Thr Leu Thr Thr Leu 
    50                  55                  60                  


Trp Ser Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser 
65                  70                  75                  80  


Phe Ser Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met 
                85                  90                  95      


Leu Met Met Asn Leu Leu Ala Phe Val Ser Ala Val Leu Met Gly Phe 
            100                 105                 110         


Ser Lys Leu Gly Lys Ser Phe Glu Met Leu Ile Leu Gly Arg Phe Ile 
        115                 120                 125             


Ile Gly Val Tyr Cys Gly Leu Thr Thr Gly Phe Val Pro Met Tyr Val 
    130                 135                 140                 


Gly Glu Val Ser Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Leu His 
145                 150                 155                 160 


Gln Leu Gly Ile Val Val Gly Ile Leu Ile Ala Gln Val Phe Gly Leu 
                165                 170                 175     


Asp Ser Ile Met Gly Asn Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro 
        195                 200                 205             


Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala 
    210                 215                 220                 


Lys Ser Val Leu Lys Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp 
225                 230                 235                 240 


Leu Gln Glu Met Lys Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys 
                245                 250                 255     


Val Thr Ile Leu Glu Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro Ile 
            260                 265                 270         


Leu Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
        275                 280                 285             


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Lys Ala Gly Val Gln 
    290                 295                 300                 


Gln Pro Val Tyr Ala Thr Ile Gly Ser Gly Ile Val Asn Thr Ala Phe 
305                 310                 315                 320 


Thr Val Val Ser Leu Phe Val Val Glu Arg Ala Gly Arg Arg Thr Leu 
                325                 330                 335     


His Leu Ile Gly Leu Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr 
            340                 345                 350         


Ile Ala Leu Ala Leu Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser 
        355                 360                 365             


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly 
    370                 375                 380                 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Ala Ile Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
                405                 410                 415     


Ile Val Gly Met Cys Phe Gln Tyr Val Glu Gln Leu Cys Gly Pro Tyr 
            420                 425                 430         


Val Phe Ile Ile Phe Thr Val Leu Leu Val Leu Phe Phe Ile Phe Thr 
        435                 440                 445             


Tyr Phe Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala 
    450                 455                 460                 


Ser Gly Phe Arg Gln Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Phe His Pro Leu Gly Ala Asp Ser Gln Val Lys Val Pro Val 
                485                 490                 495     


Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr 
            500                 505                 510         


Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln 
        515                 520                 525             


Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly 
    530                 535                 540                 


Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly 
545                 550                 555                 560 


Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val 
                565                 570                 575     


Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr 
            580                 585                 590         


Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg 
        595                 600                 605             


Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr 
    610                 615                 620                 


Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn 
625                 630                 635                 640 


Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly 
                645                 650                 655     


Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly Gly Ser Pro Ser 
            660                 665                 670         


Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
        675                 680                 685 


<210> 432
<211> 2699
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 432
Met Ala Arg Phe Gly Asp Glu Met Pro Ala Arg Tyr Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ala Ala Ala Gly Val Val Val Gly Ser Gly Gly Gly Arg Gly 
            20                  25                  30          


Ala Gly Gly Ser Arg Gln Gly Gly Gln Pro Gly Ala Gln Arg Met Tyr 
        35                  40                  45              


Lys Gln Ser Met Ala Gln Arg Ala Arg Thr Met Ala Leu Tyr Asn Pro 
    50                  55                  60                  


Ile Pro Val Arg Gln Asn Cys Leu Thr Val Asn Arg Ser Leu Phe Leu 
65                  70                  75                  80  


Phe Ser Glu Asp Asn Val Val Arg Lys Tyr Ala Lys Lys Ile Thr Glu 
                85                  90                  95      


Trp Pro Pro Phe Glu Tyr Met Ile Leu Ala Thr Ile Ile Ala Asn Cys 
            100                 105                 110         


Ile Val Leu Ala Leu Glu Gln His Leu Pro Asp Asp Asp Lys Thr Pro 
        115                 120                 125             


Met Ser Glu Arg Leu Asp Asp Thr Glu Pro Tyr Phe Ile Gly Ile Phe 
    130                 135                 140                 


Cys Phe Glu Ala Gly Ile Lys Ile Ile Ala Leu Gly Phe Ala Phe His 
145                 150                 155                 160 


Lys Gly Ser Tyr Leu Arg Asn Gly Trp Asn Val Met Asp Phe Val Val 
                165                 170                 175     


Val Leu Thr Gly Ile Leu Ala Thr Val Gly Thr Glu Phe Asp Leu Arg 
            180                 185                 190         


Thr Leu Arg Ala Val Arg Val Leu Arg Pro Leu Lys Leu Val Ser Gly 
        195                 200                 205             


Ile Pro Ser Leu Gln Val Val Leu Lys Ser Ile Met Lys Ala Met Ile 
    210                 215                 220                 


Pro Leu Leu Gln Ile Gly Leu Leu Leu Phe Phe Ala Ile Leu Ile Phe 
225                 230                 235                 240 


Ala Ile Ile Gly Leu Glu Phe Tyr Met Gly Lys Phe His Thr Thr Cys 
                245                 250                 255     


Phe Glu Glu Gly Thr Asp Asp Ile Gln Gly Glu Ser Pro Ala Pro Cys 
            260                 265                 270         


Gly Thr Glu Glu Pro Ala Arg Thr Cys Pro Asn Gly Thr Lys Cys Gln 
        275                 280                 285             


Pro Tyr Trp Glu Gly Pro Asn Asn Gly Ile Thr Gln Phe Asp Asn Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp 
305                 310                 315                 320 


Thr Asp Leu Leu Tyr Asn Ser Asn Asp Ala Ser Gly Asn Thr Trp Asn 
                325                 330                 335     


Trp Leu Tyr Phe Ile Pro Leu Ile Ile Ile Gly Ser Phe Phe Met Leu 
            340                 345                 350         


Asn Leu Val Leu Gly Val Leu Ser Gly Glu Phe Ala Lys Glu Arg Glu 
        355                 360                 365             


Arg Val Glu Asn Arg Arg Ala Phe Leu Lys Leu Arg Arg Gln Gln Gln 
    370                 375                 380                 


Ile Glu Arg Glu Leu Asn Gly Tyr Met Glu Trp Ile Ser Lys Ala Glu 
385                 390                 395                 400 


Glu Val Ile Leu Ala Glu Asp Glu Thr Asp Gly Glu Gln Arg His Pro 
                405                 410                 415     


Phe Asp Ala Leu Arg Arg Thr Thr Ile Lys Lys Ser Lys Thr Asp Leu 
            420                 425                 430         


Leu Asn Pro Glu Glu Ala Glu Asp Gln Leu Ala Asp Ile Ala Ser Val 
        435                 440                 445             


Gly Ser Pro Phe Ala Arg Ala Ser Ile Lys Ser Ala Lys Leu Glu Asn 
    450                 455                 460                 


Ser Thr Phe Phe His Lys Lys Glu Arg Arg Met Arg Phe Tyr Ile Arg 
465                 470                 475                 480 


Arg Met Val Lys Thr Gln Ala Phe Tyr Trp Thr Val Leu Ser Leu Val 
                485                 490                 495     


Ala Leu Asn Thr Leu Cys Val Ala Ile Val His Tyr Asn Gln Pro Glu 
            500                 505                 510         


Trp Leu Ser Asp Phe Leu Tyr Tyr Ala Glu Phe Ile Phe Leu Gly Leu 
        515                 520                 525             


Phe Met Ser Glu Met Phe Ile Lys Met Tyr Gly Leu Gly Thr Arg Pro 
    530                 535                 540                 


Tyr Phe His Ser Ser Phe Asn Cys Phe Asp Cys Gly Val Ile Ile Gly 
545                 550                 555                 560 


Ser Ile Phe Glu Val Ile Trp Ala Val Ile Lys Pro Gly Thr Ser Phe 
                565                 570                 575     


Gly Ile Ser Val Leu Arg Ala Leu Arg Leu Leu Arg Ile Phe Lys Val 
            580                 585                 590         


Thr Lys Tyr Trp Ala Ser Leu Arg Asn Leu Val Val Ser Leu Leu Asn 
        595                 600                 605             


Ser Met Lys Ser Ile Ile Ser Leu Leu Phe Leu Leu Phe Leu Phe Ile 
    610                 615                 620                 


Val Val Phe Ala Leu Leu Gly Met Gln Leu Phe Gly Gly Gln Phe Asn 
625                 630                 635                 640 


Phe Asp Glu Gly Thr Pro Pro Thr Asn Phe Asp Thr Phe Pro Ala Ala 
                645                 650                 655     


Ile Met Thr Val Phe Gln Ile Leu Thr Gly Glu Asp Trp Asn Glu Val 
            660                 665                 670         


Met Tyr Asp Gly Ile Lys Ser Gln Gly Gly Val Gln Gly Gly Met Val 
        675                 680                 685             


Phe Ser Ile Tyr Phe Ile Val Leu Thr Leu Phe Gly Asn Tyr Thr Leu 
    690                 695                 700                 


Leu Asn Val Phe Leu Ala Ile Ala Val Asp Asn Leu Ala Asn Ala Gln 
705                 710                 715                 720 


Glu Leu Thr Lys Asp Glu Gln Glu Glu Glu Glu Ala Ala Asn Gln Lys 
                725                 730                 735     


Leu Ala Leu Gln Lys Ala Lys Glu Val Ala Glu Val Ser Pro Leu Ser 
            740                 745                 750         


Ala Ala Asn Met Ser Ile Ala Val Lys Glu Gln Gln Lys Asn Gln Lys 
        755                 760                 765             


Pro Ala Lys Ser Val Trp Glu Gln Arg Thr Ser Glu Met Arg Lys Gln 
    770                 775                 780                 


Asn Leu Leu Ala Ser Arg Glu Ala Leu Tyr Asn Glu Met Asp Pro Asp 
785                 790                 795                 800 


Glu Arg Trp Lys Ala Ala Tyr Thr Arg His Leu Arg Pro Asp Met Lys 
                805                 810                 815     


Thr His Leu Asp Arg Pro Leu Val Val Asp Pro Gln Glu Asn Arg Asn 
            820                 825                 830         


Asn Asn Thr Asn Lys Ser Arg Ala Ala Glu Pro Thr Val Asp Gln Arg 
        835                 840                 845             


Leu Gly Gln Gln Arg Ala Glu Asp Phe Leu Arg Lys Gln Ala Arg Tyr 
    850                 855                 860                 


His Asp Arg Ala Arg Asp Pro Ser Gly Ser Ala Gly Leu Asp Ala Arg 
865                 870                 875                 880 


Arg Pro Trp Ala Gly Ser Gln Glu Ala Glu Leu Ser Arg Glu Gly Pro 
                885                 890                 895     


Tyr Gly Arg Glu Ser Asp His His Ala Arg Glu Gly Ser Leu Glu Gln 
            900                 905                 910         


Pro Gly Phe Trp Glu Gly Glu Ala Glu Arg Gly Lys Ala Gly Asp Pro 
        915                 920                 925             


His Arg Arg His Val His Arg Gln Gly Gly Ser Arg Glu Ser Arg Ser 
    930                 935                 940                 


Gly Ser Pro Arg Thr Gly Ala Asp Gly Glu His Arg Arg His Arg Ala 
945                 950                 955                 960 


His Arg Arg Pro Gly Glu Glu Gly Pro Glu Asp Lys Ala Glu Arg Arg 
                965                 970                 975     


Ala Arg His Arg Glu Gly Ser Arg Pro Ala Arg Gly Gly Glu Gly Glu 
            980                 985                 990         


Gly Glu Gly Pro Asp Gly Gly Glu  Arg Arg Arg Arg His  Arg His Gly 
        995                 1000                 1005             


Ala Pro  Ala Thr Tyr Glu Gly  Asp Ala Arg Arg Glu  Asp Lys Glu 
    1010                 1015                 1020             


Arg Arg  His Arg Arg Arg Lys  Glu Asn Gln Gly Ser  Gly Val Pro 
    1025                 1030                 1035             


Val Ser  Gly Pro Asn Leu Ser  Thr Thr Arg Pro Ile  Gln Gln Asp 
    1040                 1045                 1050             


Leu Gly  Arg Gln Asp Pro Pro  Leu Ala Glu Asp Ile  Asp Asn Met 
    1055                 1060                 1065             


Lys Asn  Asn Lys Leu Ala Thr  Ala Glu Ser Ala Ala  Pro His Gly 
    1070                 1075                 1080             


Ser Leu  Gly His Ala Gly Leu  Pro Gln Ser Pro Ala  Lys Met Gly 
    1085                 1090                 1095             


Asn Ser  Thr Asp Pro Gly Pro  Met Leu Ala Ile Pro  Ala Met Ala 
    1100                 1105                 1110             


Thr Asn  Pro Gln Asn Ala Ala  Ser Arg Arg Thr Pro  Asn Asn Pro 
    1115                 1120                 1125             


Gly Asn  Pro Ser Asn Pro Gly  Pro Pro Lys Thr Pro  Glu Asn Ser 
    1130                 1135                 1140             


Leu Ile  Val Thr Asn Pro Ser  Gly Thr Gln Thr Asn  Ser Ala Lys 
    1145                 1150                 1155             


Thr Ala  Arg Lys Pro Asp His  Thr Thr Val Asp Ile  Pro Pro Ala 
    1160                 1165                 1170             


Cys Pro  Pro Pro Leu Asn His  Thr Val Val Gln Val  Asn Lys Asn 
    1175                 1180                 1185             


Ala Asn  Pro Asp Pro Leu Pro  Lys Lys Glu Glu Glu  Lys Lys Glu 
    1190                 1195                 1200             


Glu Glu  Glu Asp Asp Arg Gly  Glu Asp Gly Pro Lys  Pro Met Pro 
    1205                 1210                 1215             


Pro Tyr  Ser Ser Met Phe Ile  Leu Ser Thr Thr Asn  Pro Leu Arg 
    1220                 1225                 1230             


Arg Leu  Cys His Tyr Ile Leu  Asn Leu Arg Tyr Phe  Glu Met Cys 
    1235                 1240                 1245             


Ile Leu  Met Val Ile Ala Met  Ser Ser Ile Ala Leu  Ala Ala Glu 
    1250                 1255                 1260             


Asp Pro  Val Gln Pro Asn Ala  Pro Arg Asn Asn Val  Leu Arg Tyr 
    1265                 1270                 1275             


Phe Asp  Tyr Val Phe Thr Gly  Val Phe Thr Phe Glu  Met Val Ile 
    1280                 1285                 1290             


Lys Met  Ile Asp Leu Gly Leu  Val Leu His Gln Gly  Ala Tyr Phe 
    1295                 1300                 1305             


Arg Asp  Leu Trp Asn Ile Leu  Asp Phe Ile Val Val  Ser Gly Ala 
    1310                 1315                 1320             


Leu Val  Ala Phe Ala Phe Thr  Gly Asn Ser Lys Gly  Lys Asp Ile 
    1325                 1330                 1335             


Asn Thr  Ile Lys Ser Leu Arg  Val Leu Arg Val Leu  Arg Pro Leu 
    1340                 1345                 1350             


Lys Thr  Ile Lys Arg Leu Pro  Lys Leu Lys Ala Val  Phe Asp Cys 
    1355                 1360                 1365             


Val Val  Asn Ser Leu Lys Asn  Val Phe Asn Ile Leu  Ile Val Tyr 
    1370                 1375                 1380             


Met Leu  Phe Met Phe Ile Phe  Ala Val Val Ala Val  Gln Leu Phe 
    1385                 1390                 1395             


Lys Gly  Lys Phe Phe His Cys  Thr Asp Glu Ser Lys  Glu Phe Glu 
    1400                 1405                 1410             


Lys Asp  Cys Arg Gly Lys Tyr  Leu Leu Tyr Glu Lys  Asn Glu Val 
    1415                 1420                 1425             


Lys Ala  Arg Asp Arg Glu Trp  Lys Lys Tyr Glu Phe  His Tyr Asp 
    1430                 1435                 1440             


Asn Val  Leu Trp Ala Leu Leu  Thr Leu Phe Thr Val  Ser Thr Gly 
    1445                 1450                 1455             


Glu Gly  Trp Pro Gln Val Leu  Lys His Ser Val Asp  Ala Thr Phe 
    1460                 1465                 1470             


Glu Asn  Gln Gly Pro Ser Pro  Gly Tyr Arg Met Glu  Met Ser Ile 
    1475                 1480                 1485             


Phe Tyr  Val Val Tyr Phe Val  Val Phe Pro Phe Phe  Phe Val Asn 
    1490                 1495                 1500             


Ile Phe  Val Ala Leu Ile Ile  Ile Thr Phe Gln Glu  Gln Gly Asp 
    1505                 1510                 1515             


Lys Met  Met Glu Glu Tyr Ser  Leu Glu Lys Asn Glu  Arg Ala Cys 
    1520                 1525                 1530             


Ile Asp  Phe Ala Ile Ser Ala  Lys Pro Leu Thr Arg  His Met Pro 
    1535                 1540                 1545             


Gln Asn  Lys Gln Ser Phe Gln  Tyr Arg Met Trp Gln  Phe Val Val 
    1550                 1555                 1560             


Ser Pro  Pro Phe Glu Tyr Thr  Ile Met Ala Met Ile  Ala Leu Asn 
    1565                 1570                 1575             


Thr Ile  Val Leu Met Met Lys  Phe Tyr Gly Ala Ser  Val Ala Tyr 
    1580                 1585                 1590             


Glu Asn  Ala Leu Arg Val Phe  Asn Ile Val Phe Thr  Ser Leu Phe 
    1595                 1600                 1605             


Ser Leu  Glu Cys Val Leu Lys  Val Met Ala Phe Gly  Ile Leu Asn 
    1610                 1615                 1620             


Tyr Phe  Arg Asp Ala Trp Asn  Ile Phe Asp Phe Val  Thr Val Leu 
    1625                 1630                 1635             


Gly Ser  Ile Thr Asp Ile Leu  Val Thr Glu Phe Gly  Asn Asn Phe 
    1640                 1645                 1650             


Ile Asn  Leu Ser Phe Leu Arg  Leu Phe Arg Ala Ala  Arg Leu Ile 
    1655                 1660                 1665             


Lys Leu  Leu Arg Gln Gly Tyr  Thr Ile Arg Ile Leu  Leu Trp Thr 
    1670                 1675                 1680             


Phe Val  Gln Ser Phe Lys Ala  Leu Pro Tyr Val Cys  Leu Leu Ile 
    1685                 1690                 1695             


Ala Met  Leu Phe Phe Ile Tyr  Ala Ile Ile Gly Met  Gln Val Phe 
    1700                 1705                 1710             


Gly Asn  Ile Gly Ile Asp Val  Glu Asp Glu Asp Ser  Asp Glu Asp 
    1715                 1720                 1725             


Glu Phe  Gln Ile Thr Glu His  Asn Asn Phe Arg Thr  Phe Phe Gln 
    1730                 1735                 1740             


Ala Leu  Met Leu Leu Phe Arg  Ser Ala Thr Gly Glu  Ala Trp His 
    1745                 1750                 1755             


Asn Ile  Met Leu Ser Cys Leu  Ser Gly Lys Pro Cys  Asp Lys Asn 
    1760                 1765                 1770             


Ser Gly  Ile Leu Thr Arg Glu  Cys Gly Asn Glu Phe  Ala Tyr Phe 
    1775                 1780                 1785             


Tyr Phe  Val Ser Phe Ile Phe  Leu Cys Ser Phe Leu  Met Leu Asn 
    1790                 1795                 1800             


Leu Phe  Val Ala Val Ile Met  Asp Asn Phe Glu Tyr  Leu Thr Arg 
    1805                 1810                 1815             


Asp Ser  Ser Ile Leu Gly Pro  His His Leu Asp Glu  Tyr Val Arg 
    1820                 1825                 1830             


Val Trp  Ala Glu Tyr Asp Pro  Ala Ala Trp Gly Arg  Met Pro Tyr 
    1835                 1840                 1845             


Leu Asp  Met Tyr Gln Met Leu  Arg His Met Ser Pro  Pro Leu Gly 
    1850                 1855                 1860             


Leu Gly  Lys Lys Cys Pro Ala  Arg Val Ala Tyr Lys  Arg Leu Leu 
    1865                 1870                 1875             


Arg Met  Asp Leu Pro Val Ala  Asp Asp Asn Thr Val  His Phe Asn 
    1880                 1885                 1890             


Ser Thr  Leu Met Ala Leu Ile  Arg Thr Ala Leu Asp  Ile Lys Ile 
    1895                 1900                 1905             


Ala Lys  Gly Gly Ala Asp Lys  Gln Gln Met Asp Ala  Glu Leu Arg 
    1910                 1915                 1920             


Lys Glu  Met Met Ala Ile Trp  Pro Asn Leu Ser Gln  Lys Thr Leu 
    1925                 1930                 1935             


Asp Leu  Leu Val Thr Pro His  Lys Ser Thr Asp Leu  Thr Val Gly 
    1940                 1945                 1950             


Lys Ile  Tyr Ala Ala Met Met  Ile Met Glu Tyr Tyr  Arg Gln Ser 
    1955                 1960                 1965             


Lys Ala  Lys Lys Leu Gln Ala  Met Arg Glu Glu Gln  Asp Arg Thr 
    1970                 1975                 1980             


Pro Leu  Met Phe Gln Arg Met  Glu Pro Pro Ser Pro  Thr Gln Glu 
    1985                 1990                 1995             


Gly Gly  Pro Gly Gln Asn Ala  Leu Pro Ser Thr Gln  Leu Asp Pro 
    2000                 2005                 2010             


Gly Gly  Ala Leu Met Ala His  Glu Ser Gly Leu Lys  Glu Ser Pro 
    2015                 2020                 2025             


Ser Trp  Val Thr Gln Arg Ala  Gln Glu Met Phe Gln  Lys Thr Gly 
    2030                 2035                 2040             


Thr Trp  Ser Pro Glu Gln Gly  Pro Pro Thr Asp Met  Pro Asn Ser 
    2045                 2050                 2055             


Gln Pro  Asn Ser Gln Ser Val  Glu Met Arg Glu Met  Gly Arg Asp 
    2060                 2065                 2070             


Gly Tyr  Ser Asp Ser Glu His  Tyr Leu Pro Met Glu  Gly Gln Gly 
    2075                 2080                 2085             


Arg Ala  Ala Ser Met Pro Arg  Leu Pro Ala Glu Asn  Gln Arg Arg 
    2090                 2095                 2100             


Arg Gly  Arg Pro Arg Gly Asn  Asn Leu Ser Thr Ile  Ser Asp Thr 
    2105                 2110                 2115             


Ser Pro  Met Lys Arg Ser Ala  Ser Val Leu Gly Pro  Lys Ala Arg 
    2120                 2125                 2130             


Arg Leu  Asp Asp Tyr Ser Leu  Glu Arg Val Pro Pro  Glu Glu Asn 
    2135                 2140                 2145             


Gln Arg  His His Gln Arg Arg  Arg Asp Arg Ser His  Arg Ala Ser 
    2150                 2155                 2160             


Glu Arg  Ser Leu Gly Arg Tyr  Thr Asp Val Asp Thr  Gly Leu Gly 
    2165                 2170                 2175             


Thr Asp  Leu Ser Met Thr Thr  Gln Ser Gly Asp Leu  Pro Ser Lys 
    2180                 2185                 2190             


Glu Arg  Asp Gln Glu Arg Gly  Arg Pro Lys Asp Arg  Lys His Arg 
    2195                 2200                 2205             


Gln His  His His His His His  His His His His Pro  Pro Pro Pro 
    2210                 2215                 2220             


Asp Lys  Asp Arg Tyr Ala Gln  Glu Arg Pro Asp His  Gly Arg Ala 
    2225                 2230                 2235             


Arg Ala  Arg Asp Gln Arg Trp  Ser Arg Ser Pro Ser  Glu Gly Arg 
    2240                 2245                 2250             


Glu His  Met Ala His Arg Gln  Gly Ser Ser Ser Val  Ser Gly Ser 
    2255                 2260                 2265             


Pro Ala  Pro Ser Thr Ser Gly  Thr Ser Thr Pro Arg  Arg Gly Arg 
    2270                 2275                 2280             


Arg Gln  Leu Pro Gln Thr Pro  Ser Thr Pro Arg Pro  His Val Ser 
    2285                 2290                 2295             


Tyr Ser  Pro Val Ile Arg Lys  Ala Gly Gly Ser Gly  Pro Pro Gln 
    2300                 2305                 2310             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln Gln Gln  Ala Val Ala 
    2315                 2320                 2325             


Arg Pro  Gly Arg Ala Ala Thr  Ser Gly Pro Arg Arg  Tyr Pro Gly 
    2330                 2335                 2340             


Pro Thr  Ala Glu Pro Leu Ala  Gly Asp Arg Pro Pro  Thr Gly Gly 
    2345                 2350                 2355             


His Ser  Ser Gly Arg Ser Pro  Arg Met Glu Arg Arg  Val Pro Gly 
    2360                 2365                 2370             


Pro Ala  Arg Ser Glu Ser Pro  Arg Ala Cys Arg His  Gly Gly Ala 
    2375                 2380                 2385             


Arg Trp  Pro Ala Ser Gly Pro  His Val Ser Glu Gly  Pro Pro Gly 
    2390                 2395                 2400             


Pro Arg  His His Gly Tyr Tyr  Arg Gly Ser Asp Tyr  Asp Glu Ala 
    2405                 2410                 2415             


Asp Gly  Pro Gly Ser Gly Gly  Gly Glu Glu Ala Met  Ala Gly Ala 
    2420                 2425                 2430             


Tyr Asp  Ala Pro Pro Pro Val  Arg His Ala Ser Ser  Gly Ala Thr 
    2435                 2440                 2445             


Gly Arg  Ser Pro Arg Thr Pro  Arg Ala Ser Gly Pro  Ala Cys Ala 
    2450                 2455                 2460             


Ser Pro  Ser Arg His Gly Arg  Arg Leu Pro Asn Gly  Tyr Tyr Pro 
    2465                 2470                 2475             


Ala His  Gly Leu Ala Arg Pro  Arg Gly Pro Gly Ser  Arg Lys Gly 
    2480                 2485                 2490             


Leu His  Glu Pro Tyr Ser Glu  Ser Asp Asp Asp Trp  Cys Lys Val 
    2495                 2500                 2505             


Pro Val  Phe Thr Leu Glu Asp  Phe Val Gly Asp Trp  Arg Gln Thr 
    2510                 2515                 2520             


Ala Gly  Tyr Asn Leu Asp Gln  Val Leu Glu Gln Gly  Gly Val Ser 
    2525                 2530                 2535             


Ser Leu  Phe Gln Asn Leu Gly  Val Ser Val Thr Pro  Ile Gln Arg 
    2540                 2545                 2550             


Ile Val  Leu Ser Gly Glu Asn  Gly Leu Lys Ile Asp  Ile His Val 
    2555                 2560                 2565             


Ile Ile  Pro Tyr Glu Gly Leu  Ser Gly Asp Gln Met  Gly Gln Ile 
    2570                 2575                 2580             


Glu Lys  Ile Phe Lys Val Val  Tyr Pro Val Asp Asp  His His Phe 
    2585                 2590                 2595             


Lys Val  Ile Leu His Tyr Gly  Thr Leu Val Ile Asp  Gly Val Thr 
    2600                 2605                 2610             


Pro Asn  Met Ile Asp Tyr Phe  Gly Arg Pro Tyr Glu  Gly Ile Ala 
    2615                 2620                 2625             


Val Phe  Asp Gly Lys Lys Ile  Thr Val Thr Gly Thr  Leu Trp Asn 
    2630                 2635                 2640             


Gly Asn  Lys Ile Ile Asp Glu  Arg Leu Ile Asn Pro  Asp Gly Ser 
    2645                 2650                 2655             


Leu Leu  Phe Arg Val Thr Ile  Asn Gly Val Thr Gly  Trp Arg Leu 
    2660                 2665                 2670             


Cys Glu  Arg Ile Leu Ala Gly  Gly Gly Gly Ser Pro  Ser Arg Leu 
    2675                 2680                 2685             


Glu Glu  Glu Leu Arg Arg Arg  Leu Thr Glu Pro 
    2690                 2695                 


<210> 433
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 433
Met Trp Gly Leu Ala Gly Gly Arg Leu Phe Gly Ile Phe Ser Ala Pro 
1               5                   10                  15      


Val Leu Val Ala Val Val Cys Cys Ala Gln Ser Val Asn Asp Pro Gly 
            20                  25                  30          


Asn Met Ser Phe Val Lys Glu Thr Val Asp Lys Leu Leu Lys Gly Tyr 
        35                  40                  45              


Asp Ile Arg Leu Arg Pro Asp Phe Gly Gly Pro Pro Val Cys Val Gly 
    50                  55                  60                  


Met Asn Ile Asp Ile Ala Ser Ile Asp Met Val Ser Glu Val Asn Met 
65                  70                  75                  80  


Asp Tyr Thr Leu Thr Met Tyr Phe Gln Gln Tyr Trp Arg Asp Lys Arg 
                85                  90                  95      


Leu Ala Tyr Ser Gly Ile Pro Leu Asn Leu Thr Leu Asp Asn Arg Val 
            100                 105                 110         


Ala Asp Gln Leu Trp Val Pro Asp Thr Tyr Phe Leu Asn Asp Lys Lys 
        115                 120                 125             


Ser Phe Val His Gly Val Thr Val Lys Asn Arg Met Ile Arg Leu His 
    130                 135                 140                 


Pro Asp Gly Thr Val Leu Tyr Gly Leu Arg Ile Thr Thr Thr Ala Ala 
145                 150                 155                 160 


Cys Met Met Asp Leu Arg Arg Tyr Pro Leu Asp Glu Gln Asn Cys Thr 
                165                 170                 175     


Leu Glu Ile Glu Ser Tyr Gly Tyr Thr Thr Asp Asp Ile Glu Phe Tyr 
            180                 185                 190         


Trp Arg Gly Gly Asp Lys Ala Val Thr Gly Val Glu Arg Ile Glu Leu 
        195                 200                 205             


Pro Gln Phe Ser Ile Val Glu His Arg Leu Val Ser Arg Asn Val Val 
    210                 215                 220                 


Phe Ala Thr Gly Ala Tyr Pro Arg Leu Ser Leu Ser Phe Arg Leu Lys 
225                 230                 235                 240 


Arg Asn Ile Gly Tyr Phe Ile Leu Gln Thr Tyr Met Pro Ser Ile Leu 
                245                 250                 255     


Ile Thr Ile Leu Ser Trp Val Ser Phe Trp Ile Asn Tyr Asp Ala Ser 
            260                 265                 270         


Ala Ala Arg Val Ala Leu Gly Ile Thr Thr Val Leu Thr Met Thr Thr 
        275                 280                 285             


Ile Asn Thr His Leu Arg Glu Thr Leu Pro Lys Ile Pro Tyr Val Lys 
    290                 295                 300                 


Ala Ile Asp Met Tyr Leu Met Gly Cys Phe Val Phe Val Phe Leu Ala 
305                 310                 315                 320 


Leu Leu Glu Tyr Ala Phe Val Asn Tyr Ile Phe Phe Gly Arg Gly Pro 
                325                 330                 335     


Gln Arg Gln Lys Lys Leu Ala Glu Lys Thr Ala Lys Ala Lys Asn Asp 
            340                 345                 350         


Arg Ser Lys Ser Glu Ser Asn Arg Val Asp Ala His Gly Asn Ile Leu 
        355                 360                 365             


Leu Thr Ser Leu Glu Val His Asn Glu Met Asn Glu Val Ser Gly Gly 
    370                 375                 380                 


Ile Gly Asp Thr Arg Asn Ser Ala Ile Ser Phe Asp Asn Ser Gly Ile 
385                 390                 395                 400 


Gln Tyr Arg Lys Gln Ser Met Pro Arg Glu Gly His Gly Arg Phe Leu 
                405                 410                 415     


Gly Asp Arg Ser Leu Pro His Lys Lys Thr His Leu Arg Arg Arg Ser 
            420                 425                 430         


Ser Gln Leu Lys Ile Lys Ile Pro Asp Leu Thr Asp Val Asn Ala Ile 
        435                 440                 445             


Asp Arg Trp Ser Arg Ile Val Phe Pro Phe Thr Phe Ser Leu Phe Asn 
    450                 455                 460                 


Leu Val Tyr Trp Leu Tyr Tyr Val Asn Lys Val Pro Val Phe Thr Leu 
465                 470                 475                 480 


Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp 
                485                 490                 495     


Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly 
            500                 505                 510         


Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly 
        515                 520                 525             


Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly 
    530                 535                 540                 


Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val 
545                 550                 555                 560 


Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile 
                565                 570                 575     


Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu 
            580                 585                 590         


Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu 
        595                 600                 605             


Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly 
    610                 615                 620                 


Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg Leu 
625                 630                 635                 640 


Cys Glu Arg Ile Leu Ala Gly Gly Gly Gly Ser Pro Ser Arg Leu Glu 
                645                 650                 655     


Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
            660                 665     


<210> 434
<211> 792
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 434
Met Ala Thr Asn Gly Ser Lys Val Ala Asp Gly Gln Ile Ser Thr Glu 
1               5                   10                  15      


Val Ser Glu Ala Pro Val Ala Asn Asp Lys Pro Lys Thr Leu Val Val 
            20                  25                  30          


Lys Val Gln Lys Lys Ala Ala Asp Leu Pro Asp Arg Asp Thr Trp Lys 
        35                  40                  45              


Gly Arg Phe Asp Phe Leu Met Ser Cys Val Gly Tyr Ala Ile Gly Leu 
    50                  55                  60                  


Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gly Lys Asn Gly Gly Gly 
65                  70                  75                  80  


Ala Phe Leu Ile Pro Tyr Phe Leu Thr Leu Ile Phe Ala Gly Val Pro 
                85                  90                  95      


Leu Phe Leu Leu Glu Cys Ser Leu Gly Gln Tyr Thr Ser Ile Gly Gly 
            100                 105                 110         


Leu Gly Val Trp Lys Leu Ala Pro Met Phe Lys Gly Val Gly Leu Ala 
        115                 120                 125             


Ala Ala Val Leu Ser Phe Trp Leu Asn Ile Tyr Tyr Ile Val Ile Ile 
    130                 135                 140                 


Ser Trp Ala Ile Tyr Tyr Leu Tyr Asn Ser Phe Thr Thr Thr Leu Pro 
145                 150                 155                 160 


Trp Lys Gln Cys Asp Asn Pro Trp Asn Thr Asp Arg Cys Phe Ser Asn 
                165                 170                 175     


Tyr Ser Met Val Asn Thr Thr Asn Met Thr Ser Ala Val Val Glu Phe 
            180                 185                 190         


Trp Glu Arg Asn Met His Gln Met Thr Asp Gly Leu Asp Lys Pro Gly 
        195                 200                 205             


Gln Ile Arg Trp Pro Leu Ala Ile Thr Leu Ala Ile Ala Trp Ile Leu 
    210                 215                 220                 


Val Tyr Phe Cys Ile Trp Lys Gly Val Gly Trp Thr Gly Lys Val Val 
225                 230                 235                 240 


Tyr Phe Ser Ala Thr Tyr Pro Tyr Ile Met Leu Ile Ile Leu Phe Phe 
                245                 250                 255     


Arg Gly Val Thr Leu Pro Gly Ala Lys Glu Gly Ile Leu Phe Tyr Ile 
            260                 265                 270         


Thr Pro Asn Phe Arg Lys Leu Ser Asp Ser Glu Val Trp Leu Asp Ala 
        275                 280                 285             


Ala Thr Gln Ile Phe Phe Ser Tyr Gly Leu Gly Leu Gly Ser Leu Ile 
    290                 295                 300                 


Ala Leu Gly Ser Tyr Asn Ser Phe His Asn Asn Val Tyr Arg Asp Ser 
305                 310                 315                 320 


Ile Ile Val Cys Cys Ile Asn Ser Cys Thr Ser Met Phe Ala Gly Phe 
                325                 330                 335     


Val Ile Phe Ser Ile Val Gly Phe Met Ala His Val Thr Lys Arg Ser 
            340                 345                 350         


Ile Ala Asp Val Ala Ala Ser Gly Pro Gly Leu Ala Phe Leu Ala Tyr 
        355                 360                 365             


Pro Glu Ala Val Thr Gln Leu Pro Ile Ser Pro Leu Trp Ala Ile Leu 
    370                 375                 380                 


Phe Phe Ser Met Leu Leu Met Leu Gly Ile Asp Ser Gln Phe Cys Thr 
385                 390                 395                 400 


Val Glu Gly Phe Ile Thr Ala Leu Val Asp Glu Tyr Pro Arg Leu Leu 
                405                 410                 415     


Arg Asn Arg Arg Glu Leu Phe Ile Ala Ala Val Cys Ile Ile Ser Tyr 
            420                 425                 430         


Leu Ile Gly Leu Ser Asn Ile Thr Gln Gly Gly Ile Tyr Val Phe Lys 
        435                 440                 445             


Leu Phe Asp Tyr Tyr Ser Ala Ser Gly Met Ser Leu Leu Phe Leu Val 
    450                 455                 460                 


Phe Phe Glu Cys Val Ser Ile Ser Trp Phe Tyr Gly Val Asn Arg Phe 
465                 470                 475                 480 


Tyr Asp Asn Ile Gln Glu Met Val Gly Ser Arg Pro Cys Ile Trp Trp 
                485                 490                 495     


Lys Leu Cys Trp Ser Phe Phe Thr Pro Ile Ile Val Ala Gly Val Phe 
            500                 505                 510         


Ile Phe Ser Ala Val Gln Met Thr Pro Leu Thr Met Gly Asn Tyr Val 
        515                 520                 525             


Phe Pro Lys Trp Gly Gln Gly Val Gly Trp Leu Met Ala Leu Ser Ser 
    530                 535                 540                 


Met Val Leu Ile Pro Gly Tyr Met Ala Tyr Met Phe Leu Thr Leu Lys 
545                 550                 555                 560 


Gly Ser Leu Lys Gln Arg Ile Gln Val Met Val Gln Pro Ser Glu Asp 
                565                 570                 575     


Ile Val Arg Pro Glu Asn Gly Pro Glu Gln Pro Gln Ala Gly Ser Ser 
            580                 585                 590         


Thr Ser Lys Glu Ala Tyr Ile Lys Val Pro Val Phe Thr Leu Glu Asp 
        595                 600                 605             


Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val 
    610                 615                 620                 


Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser 
625                 630                 635                 640 


Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys 
                645                 650                 655     


Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln 
            660                 665                 670         


Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp 
        675                 680                 685             


His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly 
    690                 695                 700                 


Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile 
705                 710                 715                 720 


Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn 
                725                 730                 735     


Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu 
            740                 745                 750         


Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu 
        755                 760                 765             


Arg Ile Leu Ala Gly Gly Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu 
    770                 775                 780                 


Leu Arg Arg Arg Leu Thr Glu Pro 
785                 790         


<210> 435
<211> 1065
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 435
Met Val Gln Lys Ser Arg Asn Gly Gly Val Tyr Pro Gly Pro Ser Gly 
1               5                   10                  15      


Glu Lys Lys Leu Lys Val Gly Phe Val Gly Leu Asp Pro Gly Ala Pro 
            20                  25                  30          


Asp Ser Thr Arg Asp Gly Ala Leu Leu Ile Ala Gly Ser Glu Ala Pro 
        35                  40                  45              


Lys Arg Gly Ser Ile Leu Ser Lys Pro Arg Ala Gly Gly Ala Gly Ala 
    50                  55                  60                  


Gly Lys Pro Pro Lys Arg Asn Ala Phe Tyr Arg Lys Leu Gln Asn Phe 
65                  70                  75                  80  


Leu Tyr Asn Val Leu Glu Arg Pro Arg Gly Trp Ala Phe Ile Tyr His 
                85                  90                  95      


Ala Tyr Val Phe Leu Leu Val Phe Ser Cys Leu Val Leu Ser Val Phe 
            100                 105                 110         


Ser Thr Ile Lys Glu Tyr Glu Lys Ser Ser Glu Gly Ala Leu Tyr Ile 
        115                 120                 125             


Leu Glu Ile Val Thr Ile Val Val Phe Gly Val Glu Tyr Phe Val Arg 
    130                 135                 140                 


Ile Trp Ala Ala Gly Cys Cys Cys Arg Tyr Arg Gly Trp Arg Gly Arg 
145                 150                 155                 160 


Leu Lys Phe Ala Arg Lys Pro Phe Cys Val Ile Asp Ile Met Val Leu 
                165                 170                 175     


Ile Ala Ser Ile Ala Val Leu Ala Ala Gly Ser Gln Gly Asn Val Phe 
            180                 185                 190         


Ala Thr Ser Ala Leu Arg Ser Leu Arg Phe Leu Gln Ile Leu Arg Met 
        195                 200                 205             


Ile Arg Met Asp Arg Arg Gly Gly Thr Trp Lys Leu Leu Gly Ser Val 
    210                 215                 220                 


Val Tyr Ala His Ser Lys Glu Leu Val Thr Ala Trp Tyr Ile Gly Phe 
225                 230                 235                 240 


Leu Cys Leu Ile Leu Ala Ser Phe Leu Val Tyr Leu Ala Glu Lys Gly 
                245                 250                 255     


Glu Asn Asp His Phe Asp Thr Tyr Ala Asp Ala Leu Trp Trp Gly Leu 
            260                 265                 270         


Ile Thr Leu Thr Thr Ile Gly Tyr Gly Asp Lys Tyr Pro Gln Thr Trp 
        275                 280                 285             


Asn Gly Arg Leu Leu Ala Ala Thr Phe Thr Leu Ile Gly Val Ser Phe 
    290                 295                 300                 


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
305                 310                 315                 320 


Gln Glu Gln His Arg Gln Lys His Phe Glu Lys Arg Arg Asn Pro Ala 
                325                 330                 335     


Ala Gly Leu Ile Gln Ser Ala Trp Arg Phe Tyr Ala Thr Asn Leu Ser 
            340                 345                 350         


Arg Thr Asp Leu His Ser Thr Trp Gln Tyr Tyr Glu Arg Thr Val Thr 
        355                 360                 365             


Val Pro Met Tyr Ser Ser Gln Thr Gln Thr Tyr Gly Ala Ser Arg Leu 
    370                 375                 380                 


Ile Pro Pro Leu Asn Gln Leu Glu Leu Leu Arg Asn Leu Lys Ser Lys 
385                 390                 395                 400 


Ser Gly Leu Ala Phe Arg Lys Asp Pro Pro Pro Glu Pro Ser Pro Ser 
                405                 410                 415     


Lys Gly Ser Pro Cys Arg Gly Pro Leu Cys Gly Cys Cys Pro Gly Arg 
            420                 425                 430         


Ser Ser Gln Lys Val Ser Leu Lys Asp Arg Val Phe Ser Ser Pro Arg 
        435                 440                 445             


Gly Val Ala Ala Lys Gly Lys Gly Ser Pro Gln Ala Gln Thr Val Arg 
    450                 455                 460                 


Arg Ser Pro Ser Ala Asp Gln Ser Leu Glu Asp Ser Pro Ser Lys Val 
465                 470                 475                 480 


Pro Lys Ser Trp Ser Phe Gly Asp Arg Ser Arg Ala Arg Gln Ala Phe 
                485                 490                 495     


Arg Ile Lys Gly Ala Ala Ser Arg Gln Asn Ser Glu Glu Ala Ser Leu 
            500                 505                 510         


Pro Gly Glu Asp Ile Val Asp Asp Lys Ser Cys Pro Cys Glu Phe Val 
        515                 520                 525             


Thr Glu Asp Leu Thr Pro Gly Leu Lys Val Ser Ile Arg Ala Val Cys 
    530                 535                 540                 


Val Met Arg Phe Leu Val Ser Lys Arg Lys Phe Lys Glu Ser Leu Arg 
545                 550                 555                 560 


Pro Tyr Asp Val Met Asp Val Ile Glu Gln Tyr Ser Ala Gly His Leu 
                565                 570                 575     


Asp Met Leu Ser Arg Ile Lys Ser Leu Gln Ser Arg Val Asp Gln Ile 
            580                 585                 590         


Val Gly Arg Gly Pro Ala Ile Thr Asp Lys Asp Arg Thr Lys Gly Pro 
        595                 600                 605             


Ala Glu Ala Glu Leu Pro Glu Asp Pro Ser Met Met Gly Arg Leu Gly 
    610                 615                 620                 


Lys Val Glu Lys Gln Val Leu Ser Met Glu Lys Lys Leu Asp Phe Leu 
625                 630                 635                 640 


Val Asn Ile Tyr Met Gln Arg Met Gly Ile Pro Pro Thr Glu Thr Glu 
                645                 650                 655     


Ala Tyr Phe Gly Ala Lys Glu Pro Glu Pro Ala Pro Pro Tyr His Ser 
            660                 665                 670         


Pro Glu Asp Ser Arg Glu His Val Asp Arg His Gly Cys Ile Val Lys 
        675                 680                 685             


Ile Val Arg Ser Ser Ser Ser Thr Gly Gln Lys Asn Phe Ser Ala Pro 
    690                 695                 700                 


Pro Ala Ala Pro Pro Val Gln Cys Pro Pro Ser Thr Ser Trp Gln Pro 
705                 710                 715                 720 


Gln Ser His Pro Arg Gln Gly His Gly Thr Ser Pro Val Gly Asp His 
                725                 730                 735     


Gly Ser Leu Val Arg Ile Pro Pro Pro Pro Ala His Glu Arg Ser Leu 
            740                 745                 750         


Ser Ala Tyr Gly Gly Gly Asn Arg Ala Ser Met Glu Phe Leu Arg Gln 
        755                 760                 765             


Glu Asp Thr Pro Gly Cys Arg Pro Pro Glu Gly Asn Leu Arg Asp Ser 
    770                 775                 780                 


Asp Thr Ser Ile Ser Ile Pro Ser Val Asp His Glu Glu Leu Glu Arg 
785                 790                 795                 800 


Ser Phe Ser Gly Phe Ser Ile Ser Gln Ser Lys Glu Asn Leu Asp Ala 
                805                 810                 815     


Leu Asn Ser Cys Tyr Ala Ala Val Ala Pro Cys Ala Lys Val Arg Pro 
            820                 825                 830         


Tyr Ile Ala Glu Gly Glu Ser Asp Thr Asp Ser Asp Leu Cys Thr Pro 
        835                 840                 845             


Cys Gly Pro Pro Pro Arg Ser Ala Thr Gly Glu Gly Pro Phe Gly Asp 
    850                 855                 860                 


Val Gly Trp Ala Gly Pro Arg Lys Lys Val Pro Val Phe Thr Leu Glu 
865                 870                 875                 880 


Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln 
                885                 890                 895     


Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val 
            900                 905                 910         


Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu 
        915                 920                 925             


Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp 
    930                 935                 940                 


Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val Asp 
945                 950                 955                 960 


Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile Asp 
                965                 970                 975     


Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly 
            980                 985                 990         


Ile Ala Val Phe Asp Gly Lys Lys  Ile Thr Val Thr Gly  Thr Leu Trp 
        995                 1000                 1005             


Asn Gly  Asn Lys Ile Ile Asp  Glu Arg Leu Ile Asn  Pro Asp Gly 
    1010                 1015                 1020             


Ser Leu  Leu Phe Arg Val Thr  Ile Asn Gly Val Thr  Gly Trp Arg 
    1025                 1030                 1035             


Leu Cys  Glu Arg Ile Leu Ala  Gly Gly Gly Gly Ser  Pro Ser Arg 
    1040                 1045                 1050             


Leu Glu  Glu Glu Leu Arg Arg  Arg Leu Thr Glu Pro  
    1055                 1060                 1065 


<210> 436
<211> 2173
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 436
Met Ala Ala Arg Leu Leu Ala Pro Pro Gly Pro Asp Ser Phe Lys Pro 
1               5                   10                  15      


Phe Thr Pro Glu Ser Leu Ala Asn Ile Glu Arg Arg Ile Ala Glu Ser 
            20                  25                  30          


Lys Leu Lys Lys Pro Pro Lys Ala Asp Gly Ser His Arg Glu Asp Asp 
        35                  40                  45              


Glu Asp Ser Lys Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser 
    50                  55                  60                  


Leu Pro Phe Ile Tyr Gly Asp Ile Pro Gln Gly Leu Val Ala Val Pro 
65                  70                  75                  80  


Leu Glu Asp Phe Asp Pro Tyr Tyr Leu Thr Gln Lys Thr Phe Val Val 
                85                  90                  95      


Leu Asn Arg Gly Lys Thr Leu Phe Arg Phe Ser Ala Thr Pro Ala Leu 
            100                 105                 110         


Tyr Ile Leu Ser Pro Phe Asn Leu Ile Arg Arg Ile Ala Ile Lys Ile 
        115                 120                 125             


Leu Ile His Ser Val Phe Ser Met Ile Ile Met Cys Thr Ile Leu Thr 
    130                 135                 140                 


Asn Cys Val Phe Met Thr Phe Ser Asn Pro Pro Asp Trp Ser Lys Asn 
145                 150                 155                 160 


Val Glu Tyr Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Val Lys 
                165                 170                 175     


Ile Ile Ala Arg Gly Phe Cys Ile Asp Gly Phe Thr Phe Leu Arg Asp 
            180                 185                 190         


Pro Trp Asn Trp Leu Asp Phe Ser Val Ile Met Met Ala Tyr Ile Thr 
        195                 200                 205             


Glu Phe Val Asn Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val 
    210                 215                 220                 


Leu Arg Ala Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile 
225                 230                 235                 240 


Val Gly Ala Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile 
                245                 250                 255     


Leu Thr Val Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu 
            260                 265                 270         


Phe Met Gly Asn Leu Arg Asn Lys Cys Val Val Trp Pro Ile Asn Phe 
        275                 280                 285             


Asn Glu Ser Tyr Leu Glu Asn Gly Thr Lys Gly Phe Asp Trp Glu Glu 
    290                 295                 300                 


Tyr Ile Asn Asn Lys Thr Asn Phe Tyr Thr Val Pro Gly Met Leu Glu 
305                 310                 315                 320 


Pro Leu Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly 
                325                 330                 335     


Tyr Gln Cys Met Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser 
            340                 345                 350         


Phe Asp Thr Phe Ser Trp Ala Phe Leu Ala Leu Phe Arg Leu Met Thr 
        355                 360                 365             


Gln Asp Tyr Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly 
    370                 375                 380                 


Lys Thr Tyr Met Ile Phe Phe Val Leu Val Ile Phe Val Gly Ser Phe 
385                 390                 395                 400 


Tyr Leu Val Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu 
                405                 410                 415     


Gln Asn Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe 
            420                 425                 430         


Lys Ala Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala 
        435                 440                 445             


Ala Ala Met Ala Thr Ser Ala Gly Thr Val Ser Glu Asp Ala Ile Glu 
    450                 455                 460                 


Glu Glu Gly Glu Glu Gly Gly Gly Ser Pro Arg Ser Ser Ser Glu Ile 
465                 470                 475                 480 


Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu Arg Arg Asn Arg Arg Lys 
                485                 490                 495     


Lys Arg Lys Gln Lys Glu Leu Ser Glu Gly Glu Glu Lys Gly Asp Pro 
            500                 505                 510         


Glu Lys Val Phe Lys Ser Glu Ser Glu Asp Gly Met Arg Arg Lys Ala 
        515                 520                 525             


Phe Arg Leu Pro Asp Asn Arg Ile Gly Arg Lys Phe Ser Ile Met Asn 
    530                 535                 540                 


Gln Ser Leu Leu Ser Ile Pro Gly Ser Pro Phe Leu Ser Arg His Asn 
545                 550                 555                 560 


Ser Lys Ser Ser Ile Phe Ser Phe Arg Gly Pro Gly Arg Phe Arg Asp 
                565                 570                 575     


Pro Gly Ser Glu Asn Glu Phe Ala Asp Asp Glu His Ser Thr Val Glu 
            580                 585                 590         


Glu Ser Glu Gly Arg Arg Asp Ser Leu Phe Ile Pro Ile Arg Ala Arg 
        595                 600                 605             


Glu Arg Arg Ser Ser Tyr Ser Gly Tyr Ser Gly Tyr Ser Gln Gly Ser 
    610                 615                 620                 


Arg Ser Ser Arg Ile Phe Pro Ser Leu Arg Arg Ser Val Lys Arg Asn 
625                 630                 635                 640 


Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Ile Gly Gly Pro Gly 
                645                 650                 655     


Ser His Ile Gly Gly Arg Leu Leu Pro Glu Ala Thr Thr Glu Val Glu 
            660                 665                 670         


Ile Lys Lys Lys Gly Pro Gly Ser Leu Leu Val Ser Met Asp Gln Leu 
        675                 680                 685             


Ala Ser Tyr Gly Arg Lys Asp Arg Ile Asn Ser Ile Met Ser Val Val 
    690                 695                 700                 


Thr Asn Thr Leu Val Glu Glu Leu Glu Glu Ser Gln Arg Lys Cys Pro 
705                 710                 715                 720 


Pro Cys Trp Tyr Lys Phe Ala Asn Thr Phe Leu Ile Trp Glu Cys His 
                725                 730                 735     


Pro Tyr Trp Ile Lys Leu Lys Glu Ile Val Asn Leu Ile Val Met Asp 
            740                 745                 750         


Pro Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu 
        755                 760                 765             


Phe Met Ala Met Glu His His Pro Met Thr Pro Gln Phe Glu His Val 
    770                 775                 780                 


Leu Ala Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met 
785                 790                 795                 800 


Phe Leu Lys Leu Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly 
                805                 810                 815     


Trp Asn Ile Phe Asp Gly Phe Ile Val Ser Leu Ser Leu Met Glu Leu 
            820                 825                 830         


Ser Leu Ala Asp Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu 
        835                 840                 845             


Leu Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu 
    850                 855                 860                 


Ile Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu 
865                 870                 875                 880 


Val Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu 
                885                 890                 895     


Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys Lys Ile Asn Gln Asp Cys 
            900                 905                 910         


Glu Leu Pro Arg Trp His Met His Asp Phe Phe His Ser Phe Leu Ile 
        915                 920                 925             


Val Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys 
    930                 935                 940                 


Met Glu Val Ala Gly Gln Ala Met Cys Leu Ile Val Phe Met Met Val 
945                 950                 955                 960 


Met Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu 
                965                 970                 975     


Leu Ser Ser Phe Ser Ala Asp Asn Leu Ala Ala Thr Asp Asp Asp Gly 
            980                 985                 990         


Glu Met Asn Asn Leu Gln Ile Ser  Val Ile Arg Ile Lys  Lys Gly Val 
        995                 1000                 1005             


Ala Trp  Thr Lys Leu Lys Val  His Ala Phe Met Gln  Ala His Phe 
    1010                 1015                 1020             


Lys Gln  Arg Glu Ala Asp Glu  Val Lys Pro Leu Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Glu Lys  Lys Ala Asn Cys Ile  Ala Asn His Thr Gly  Ala Asp Ile 
    1040                 1045                 1050             


His Arg  Asn Gly Asp Phe Gln  Lys Asn Gly Asn Gly  Thr Thr Ser 
    1055                 1060                 1065             


Gly Ile  Gly Ser Ser Val Glu  Lys Tyr Ile Ile Asp  Glu Asp His 
    1070                 1075                 1080             


Met Ser  Phe Ile Asn Asn Pro  Asn Leu Thr Val Arg  Val Pro Ile 
    1085                 1090                 1095             


Ala Val  Gly Glu Ser Asp Phe  Glu Asn Leu Asn Thr  Glu Asp Val 
    1100                 1105                 1110             


Ser Ser  Glu Ser Asp Pro Glu  Gly Ser Lys Asp Lys  Leu Asp Asp 
    1115                 1120                 1125             


Thr Ser  Ser Ser Glu Gly Ser  Thr Ile Asp Ile Lys  Pro Glu Val 
    1130                 1135                 1140             


Glu Glu  Val Pro Val Glu Gln  Pro Glu Glu Tyr Leu  Asp Pro Asp 
    1145                 1150                 1155             


Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg Phe Lys  Cys Cys Gln 
    1160                 1165                 1170             


Val Asn  Ile Glu Glu Gly Leu  Gly Lys Ser Trp Trp  Ile Leu Arg 
    1175                 1180                 1185             


Lys Thr  Cys Phe Leu Ile Val  Glu His Asn Trp Phe  Glu Thr Phe 
    1190                 1195                 1200             


Ile Ile  Phe Met Ile Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu 
    1205                 1210                 1215             


Asp Ile  Tyr Ile Glu Gln Arg  Lys Thr Ile Arg Thr  Ile Leu Glu 
    1220                 1225                 1230             


Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu 
    1235                 1240                 1245             


Leu Lys  Trp Thr Ala Tyr Gly  Phe Val Lys Phe Phe  Thr Asn Ala 
    1250                 1255                 1260             


Trp Cys  Trp Leu Asp Phe Leu  Ile Val Ala Val Ser  Leu Val Ser 
    1265                 1270                 1275             


Leu Ile  Ala Asn Ala Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys 
    1280                 1285                 1290             


Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser 
    1295                 1300                 1305             


Arg Phe  Glu Gly Met Arg Val  Val Val Asn Ala Leu  Val Gly Ala 
    1310                 1315                 1320             


Ile Pro  Ser Ile Met Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp 
    1325                 1330                 1335             


Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu Phe Ala  Gly Lys Tyr 
    1340                 1345                 1350             


His Tyr  Cys Phe Asn Glu Thr  Ser Glu Ile Arg Phe  Glu Ile Glu 
    1355                 1360                 1365             


Asp Val  Asn Asn Lys Thr Glu  Cys Glu Lys Leu Met  Glu Gly Asn 
    1370                 1375                 1380             


Asn Thr  Glu Ile Arg Trp Lys  Asn Val Lys Ile Asn  Phe Asp Asn 
    1385                 1390                 1395             


Val Gly  Ala Gly Tyr Leu Ala  Leu Leu Gln Val Ala  Thr Phe Lys 
    1400                 1405                 1410             


Gly Trp  Met Asp Ile Met Tyr  Ala Ala Val Asp Ser  Arg Lys Pro 
    1415                 1420                 1425             


Asp Glu  Gln Pro Lys Tyr Glu  Asp Asn Ile Tyr Met  Tyr Ile Tyr 
    1430                 1435                 1440             


Phe Val  Ile Phe Ile Ile Phe  Gly Ser Phe Phe Thr  Leu Asn Leu 
    1445                 1450                 1455             


Phe Ile  Gly Val Ile Ile Asp  Asn Phe Asn Gln Gln  Lys Lys Lys 
    1460                 1465                 1470             


Phe Gly  Gly Gln Asp Ile Phe  Met Thr Glu Glu Gln  Lys Lys Tyr 
    1475                 1480                 1485             


Tyr Asn  Ala Met Lys Lys Leu  Gly Ser Lys Lys Pro  Gln Lys Pro 
    1490                 1495                 1500             


Ile Pro  Arg Pro Leu Asn Lys  Ile Gln Gly Ile Val  Phe Asp Phe 
    1505                 1510                 1515             


Val Thr  Gln Gln Ala Phe Asp  Ile Val Ile Met Met  Leu Ile Cys 
    1520                 1525                 1530             


Leu Asn  Met Val Thr Met Met  Val Glu Thr Asp Thr  Gln Ser Lys 
    1535                 1540                 1545             


Gln Met  Glu Asn Ile Leu Tyr  Trp Ile Asn Leu Val  Phe Val Ile 
    1550                 1555                 1560             


Phe Phe  Thr Cys Glu Cys Val  Leu Lys Met Phe Ala  Leu Arg His 
    1565                 1570                 1575             


Tyr Tyr  Phe Thr Ile Gly Trp  Asn Ile Phe Asp Phe  Val Val Val 
    1580                 1585                 1590             


Ile Leu  Ser Ile Val Gly Met  Phe Leu Ala Asp Ile  Ile Glu Lys 
    1595                 1600                 1605             


Tyr Phe  Val Ser Pro Thr Leu  Phe Arg Val Ile Arg  Leu Ala Arg 
    1610                 1615                 1620             


Ile Gly  Arg Ile Leu Arg Leu  Ile Lys Gly Ala Lys  Gly Ile Arg 
    1625                 1630                 1635             


Thr Leu  Leu Phe Ala Leu Met  Met Ser Leu Pro Ala  Leu Phe Asn 
    1640                 1645                 1650             


Ile Gly  Leu Leu Leu Phe Leu  Val Met Phe Ile Phe  Ser Ile Phe 
    1655                 1660                 1665             


Gly Met  Ser Asn Phe Ala Tyr  Val Lys His Glu Ala  Gly Ile Asp 
    1670                 1675                 1680             


Asp Met  Phe Asn Phe Glu Thr  Phe Gly Asn Ser Met  Ile Cys Leu 
    1685                 1690                 1695             


Phe Gln  Ile Thr Thr Ser Ala  Gly Trp Asp Gly Leu  Leu Leu Pro 
    1700                 1705                 1710             


Ile Leu  Asn Arg Pro Pro Asp  Cys Ser Leu Asp Lys  Glu His Pro 
    1715                 1720                 1725             


Gly Ser  Gly Phe Lys Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile 
    1730                 1735                 1740             


Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser Phe Leu  Ile Val Val 
    1745                 1750                 1755             


Asn Met  Tyr Ile Ala Ile Ile  Leu Glu Asn Phe Ser  Val Ala Thr 
    1760                 1765                 1770             


Glu Glu  Ser Ala Asp Pro Leu  Ser Glu Asp Asp Phe  Glu Thr Phe 
    1775                 1780                 1785             


Tyr Glu  Ile Trp Glu Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile 
    1790                 1795                 1800             


Glu Tyr  Cys Lys Leu Ala Asp  Phe Ala Asp Ala Leu  Glu His Pro 
    1805                 1810                 1815             


Leu Arg  Val Pro Lys Pro Asn  Thr Ile Glu Leu Ile  Ala Met Asp 
    1820                 1825                 1830             


Leu Pro  Met Val Ser Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu 
    1835                 1840                 1845             


Phe Ala  Phe Thr Lys Arg Val  Leu Gly Asp Ser Gly  Glu Leu Asp 
    1850                 1855                 1860             


Ile Leu  Arg Gln Gln Met Glu  Glu Arg Phe Val Ala  Ser Asn Pro 
    1865                 1870                 1875             


Ser Lys  Val Ser Tyr Glu Pro  Ile Thr Thr Thr Leu  Arg Arg Lys 
    1880                 1885                 1890             


Gln Glu  Glu Val Ser Ala Val  Val Leu Gln Arg Ala  Tyr Arg Gly 
    1895                 1900                 1905             


His Leu  Ala Arg Arg Gly Phe  Ile Cys Lys Lys Thr  Thr Ser Asn 
    1910                 1915                 1920             


Lys Leu  Glu Asn Gly Gly Thr  His Arg Glu Lys Lys  Glu Ser Thr 
    1925                 1930                 1935             


Pro Ser  Thr Ala Ser Leu Pro  Ser Tyr Asp Ser Val  Thr Lys Pro 
    1940                 1945                 1950             


Glu Lys  Glu Lys Gln Gln Arg  Ala Glu Glu Gly Arg  Arg Glu Arg 
    1955                 1960                 1965             


Ala Lys  Arg Gln Lys Glu Val  Arg Glu Ser Lys Cys  Lys Val Pro 
    1970                 1975                 1980             


Val Phe  Thr Leu Glu Asp Phe  Val Gly Asp Trp Arg  Gln Thr Ala 
    1985                 1990                 1995             


Gly Tyr  Asn Leu Asp Gln Val  Leu Glu Gln Gly Gly  Val Ser Ser 
    2000                 2005                 2010             


Leu Phe  Gln Asn Leu Gly Val  Ser Val Thr Pro Ile  Gln Arg Ile 
    2015                 2020                 2025             


Val Leu  Ser Gly Glu Asn Gly  Leu Lys Ile Asp Ile  His Val Ile 
    2030                 2035                 2040             


Ile Pro  Tyr Glu Gly Leu Ser  Gly Asp Gln Met Gly  Gln Ile Glu 
    2045                 2050                 2055             


Lys Ile  Phe Lys Val Val Tyr  Pro Val Asp Asp His  His Phe Lys 
    2060                 2065                 2070             


Val Ile  Leu His Tyr Gly Thr  Leu Val Ile Asp Gly  Val Thr Pro 
    2075                 2080                 2085             


Asn Met  Ile Asp Tyr Phe Gly  Arg Pro Tyr Glu Gly  Ile Ala Val 
    2090                 2095                 2100             


Phe Asp  Gly Lys Lys Ile Thr  Val Thr Gly Thr Leu  Trp Asn Gly 
    2105                 2110                 2115             


Asn Lys  Ile Ile Asp Glu Arg  Leu Ile Asn Pro Asp  Gly Ser Leu 
    2120                 2125                 2130             


Leu Phe  Arg Val Thr Ile Asn  Gly Val Thr Gly Trp  Arg Leu Cys 
    2135                 2140                 2145             


Glu Arg  Ile Leu Ala Gly Gly  Gly Gly Ser Pro Ser  Arg Leu Glu 
    2150                 2155                 2160             


Glu Glu  Leu Arg Arg Arg Leu  Thr Glu Pro 
    2165                 2170             


<210> 437
<211> 2198
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 437
Met Ala Gln Ser Val Leu Val Pro Pro Gly Pro Asp Ser Phe Arg Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Gln Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Arg Pro Lys Gln Glu Arg Lys Asp Glu Asp Asp Glu Asn 
        35                  40                  45              


Gly Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Ser Leu Pro Phe 
    50                  55                  60                  


Ile Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Val Pro Leu Glu Asp 
65                  70                  75                  80  


Leu Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys 
                85                  90                  95      


Gly Lys Ala Ile Ser Arg Phe Ser Ala Thr Pro Ala Leu Tyr Ile Leu 
            100                 105                 110         


Thr Pro Phe Asn Pro Ile Arg Lys Leu Ala Ile Lys Ile Leu Val His 
        115                 120                 125             


Ser Leu Phe Asn Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val 
    130                 135                 140                 


Phe Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr 
145                 150                 155                 160 


Thr Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Leu Ala 
                165                 170                 175     


Arg Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn 
            180                 185                 190         


Trp Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val 
        195                 200                 205             


Asp Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala 
    210                 215                 220                 


Leu Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala 
225                 230                 235                 240 


Leu Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val 
                245                 250                 255     


Phe Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly 
            260                 265                 270         


Asn Leu Arg Asn Lys Cys Leu Gln Trp Pro Pro Asp Asn Ser Ser Phe 
        275                 280                 285             


Glu Ile Asn Ile Thr Ser Phe Phe Asn Asn Ser Leu Asp Gly Asn Gly 
    290                 295                 300                 


Thr Thr Phe Asn Arg Thr Val Ser Ile Phe Asn Trp Asp Glu Tyr Ile 
305                 310                 315                 320 


Glu Asp Lys Ser His Phe Tyr Phe Leu Glu Gly Gln Asn Asp Ala Leu 
                325                 330                 335     


Leu Cys Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile 
            340                 345                 350         


Cys Val Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp 
        355                 360                 365             


Thr Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp 
    370                 375                 380                 


Phe Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr 
385                 390                 395                 400 


Tyr Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu 
                405                 410                 415     


Ile Asn Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn 
            420                 425                 430         


Gln Ala Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln 
        435                 440                 445             


Met Leu Glu Gln Leu Lys Lys Gln Gln Glu Glu Ala Gln Ala Ala Ala 
    450                 455                 460                 


Ala Ala Ala Ser Ala Glu Ser Arg Asp Phe Ser Gly Ala Gly Gly Ile 
465                 470                 475                 480 


Gly Val Phe Ser Glu Ser Ser Ser Val Ala Ser Lys Leu Ser Ser Lys 
                485                 490                 495     


Ser Glu Lys Glu Leu Lys Asn Arg Arg Lys Lys Lys Lys Gln Lys Glu 
            500                 505                 510         


Gln Ser Gly Glu Glu Glu Lys Asn Asp Arg Val Arg Lys Ser Glu Ser 
        515                 520                 525             


Glu Asp Ser Ile Arg Arg Lys Gly Phe Arg Phe Ser Leu Glu Gly Ser 
    530                 535                 540                 


Arg Leu Thr Tyr Glu Lys Arg Phe Ser Ser Pro His Gln Ser Leu Leu 
545                 550                 555                 560 


Ser Ile Arg Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Ala Ser 
                565                 570                 575     


Leu Phe Ser Phe Arg Gly Arg Ala Lys Asp Ile Gly Ser Glu Asn Asp 
            580                 585                 590         


Phe Ala Asp Asp Glu His Ser Thr Phe Glu Asp Asn Asp Ser Arg Arg 
        595                 600                 605             


Asp Ser Leu Phe Val Pro His Arg His Gly Glu Arg Arg His Ser Asn 
    610                 615                 620                 


Val Ser Gln Ala Ser Arg Ala Ser Arg Val Leu Pro Ile Leu Pro Met 
625                 630                 635                 640 


Asn Gly Lys Met His Ser Ala Val Asp Cys Asn Gly Val Val Ser Leu 
                645                 650                 655     


Val Gly Gly Pro Ser Thr Leu Thr Ser Ala Gly Gln Leu Leu Pro Glu 
            660                 665                 670         


Gly Thr Thr Thr Glu Thr Glu Ile Arg Lys Arg Arg Ser Ser Ser Tyr 
        675                 680                 685             


His Val Ser Met Asp Leu Leu Glu Asp Pro Thr Ser Arg Gln Arg Ala 
    690                 695                 700                 


Met Ser Ile Ala Ser Ile Leu Thr Asn Thr Met Glu Glu Leu Glu Glu 
705                 710                 715                 720 


Ser Arg Gln Lys Cys Pro Pro Cys Trp Tyr Lys Phe Ala Asn Met Cys 
                725                 730                 735     


Leu Ile Trp Asp Cys Cys Lys Pro Trp Leu Lys Val Lys His Leu Val 
            740                 745                 750         


Asn Leu Val Val Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 
        755                 760                 765             


Ile Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 
    770                 775                 780                 


Glu Gln Phe Ser Ser Val Leu Ser Val Gly Asn Leu Val Phe Thr Gly 
785                 790                 795                 800 


Ile Phe Thr Ala Glu Met Phe Leu Lys Ile Ile Ala Met Asp Pro Tyr 
                805                 810                 815     


Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly Phe Ile Val Ser 
            820                 825                 830         


Leu Ser Leu Met Glu Leu Gly Leu Ala Asn Val Glu Gly Leu Ser Val 
        835                 840                 845             


Leu Arg Ser Phe Arg Leu Leu Arg Val Phe Lys Leu Ala Lys Ser Trp 
    850                 855                 860                 


Pro Thr Leu Asn Met Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 
865                 870                 875                 880 


Leu Gly Asn Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 
                885                 890                 895     


Val Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 
            900                 905                 910         


Lys Ile Ser Asn Asp Cys Glu Leu Pro Arg Trp His Met His Asp Phe 
        915                 920                 925             


Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly Glu Trp Ile 
    930                 935                 940                 


Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly Gln Thr Met Cys Leu 
945                 950                 955                 960 


Thr Val Phe Met Met Val Met Val Ile Gly Asn Leu Val Val Leu Asn 
                965                 970                 975     


Leu Phe Leu Ala Leu Leu Leu Ser Ser Phe Ser Ser Asp Asn Leu Ala 
            980                 985                 990         


Ala Thr Asp Asp Asp Asn Glu Met  Asn Asn Leu Gln Ile  Ala Val Gly 
        995                 1000                 1005             


Arg Met  Gln Lys Gly Ile Asp  Phe Val Lys Arg Lys  Ile Arg Glu 
    1010                 1015                 1020             


Phe Ile  Gln Lys Ala Phe Val  Arg Lys Gln Lys Ala  Leu Asp Glu 
    1025                 1030                 1035             


Ile Lys  Pro Leu Glu Asp Leu  Asn Asn Lys Lys Asp  Ser Cys Ile 
    1040                 1045                 1050             


Ser Asn  His Thr Thr Ile Glu  Ile Gly Lys Asp Leu  Asn Tyr Leu 
    1055                 1060                 1065             


Lys Asp  Gly Asn Gly Thr Thr  Ser Gly Ile Gly Ser  Ser Val Glu 
    1070                 1075                 1080             


Lys Tyr  Val Val Asp Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn 
    1085                 1090                 1095             


Pro Ser  Leu Thr Val Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp 
    1100                 1105                 1110             


Phe Glu  Asn Leu Asn Thr Glu  Glu Phe Ser Ser Glu  Ser Asp Met 
    1115                 1120                 1125             


Glu Glu  Ser Lys Glu Lys Leu  Asn Ala Thr Ser Ser  Ser Glu Gly 
    1130                 1135                 1140             


Ser Thr  Val Asp Ile Gly Ala  Pro Ala Glu Gly Glu  Gln Pro Glu 
    1145                 1150                 1155             


Val Glu  Pro Glu Glu Ser Leu  Glu Pro Glu Ala Cys  Phe Thr Glu 
    1160                 1165                 1170             


Asp Cys  Val Arg Lys Phe Lys  Cys Cys Gln Ile Ser  Ile Glu Glu 
    1175                 1180                 1185             


Gly Lys  Gly Lys Leu Trp Trp  Asn Leu Arg Lys Thr  Cys Tyr Lys 
    1190                 1195                 1200             


Ile Val  Glu His Asn Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile 
    1205                 1210                 1215             


Leu Leu  Ser Ser Gly Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Glu 
    1220                 1225                 1230             


Gln Arg  Lys Thr Ile Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val 
    1235                 1240                 1245             


Phe Thr  Tyr Ile Phe Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala 
    1250                 1255                 1260             


Tyr Gly  Phe Gln Val Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp 
    1265                 1270                 1275             


Phe Leu  Ile Val Asp Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala 
    1280                 1285                 1290             


Leu Gly  Tyr Ser Glu Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu 
    1295                 1300                 1305             


Arg Ala  Leu Arg Pro Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met 
    1310                 1315                 1320             


Arg Val  Val Val Asn Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met 
    1325                 1330                 1335             


Asn Val  Leu Leu Val Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile 
    1340                 1345                 1350             


Met Gly  Val Asn Leu Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn 
    1355                 1360                 1365             


Tyr Thr  Thr Gly Glu Met Phe  Asp Val Ser Val Val  Asn Asn Tyr 
    1370                 1375                 1380             


Ser Glu  Cys Lys Ala Leu Ile  Glu Ser Asn Gln Thr  Ala Arg Trp 
    1385                 1390                 1395             


Lys Asn  Val Lys Val Asn Phe  Asp Asn Val Gly Leu  Gly Tyr Leu 
    1400                 1405                 1410             


Ser Leu  Leu Gln Val Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met 
    1415                 1420                 1425             


Tyr Ala  Ala Val Asp Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr 
    1430                 1435                 1440             


Glu Asp  Asn Leu Tyr Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile 
    1445                 1450                 1455             


Phe Gly  Ser Phe Phe Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile 
    1460                 1465                 1470             


Asp Asn  Phe Asn Gln Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile 
    1475                 1480                 1485             


Phe Met  Thr Glu Glu Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys 
    1490                 1495                 1500             


Leu Gly  Ser Lys Lys Pro Gln  Lys Pro Ile Pro Arg  Pro Ala Asn 
    1505                 1510                 1515             


Lys Phe  Gln Gly Met Val Phe  Asp Phe Val Thr Lys  Gln Val Phe 
    1520                 1525                 1530             


Asp Ile  Ser Ile Met Ile Leu  Ile Cys Leu Asn Met  Val Thr Met 
    1535                 1540                 1545             


Met Val  Glu Thr Asp Asp Gln  Ser Gln Glu Met Thr  Asn Ile Leu 
    1550                 1555                 1560             


Tyr Trp  Ile Asn Leu Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys 
    1565                 1570                 1575             


Val Leu  Lys Leu Ile Ser Leu  Arg Tyr Tyr Tyr Phe  Thr Ile Gly 
    1580                 1585                 1590             


Trp Asn  Ile Phe Asp Phe Val  Val Val Ile Leu Ser  Ile Val Gly 
    1595                 1600                 1605             


Met Phe  Leu Ala Glu Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr 
    1610                 1615                 1620             


Leu Phe  Arg Val Ile Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg 
    1625                 1630                 1635             


Leu Ile  Lys Gly Ala Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu 
    1640                 1645                 1650             


Met Met  Ser Leu Pro Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe 
    1655                 1660                 1665             


Leu Val  Met Phe Ile Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala 
    1670                 1675                 1680             


Tyr Val  Lys Arg Glu Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu 
    1685                 1690                 1695             


Thr Phe  Gly Asn Ser Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser 
    1700                 1705                 1710             


Ala Gly  Trp Asp Gly Leu Leu  Ala Pro Ile Leu Asn  Ser Gly Pro 
    1715                 1720                 1725             


Pro Asp  Cys Asp Pro Asp Lys  Asp His Pro Gly Ser  Ser Val Lys 
    1730                 1735                 1740             


Gly Asp  Cys Gly Asn Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser 
    1745                 1750                 1755             


Tyr Ile  Ile Ile Ser Phe Leu  Val Val Val Asn Met  Tyr Ile Ala 
    1760                 1765                 1770             


Val Ile  Leu Glu Asn Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu 
    1775                 1780                 1785             


Pro Leu  Ser Glu Asp Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu 
    1790                 1795                 1800             


Lys Phe  Asp Pro Asp Ala Thr  Gln Phe Ile Glu Phe  Ala Lys Leu 
    1805                 1810                 1815             


Ser Asp  Phe Ala Asp Ala Leu  Asp Pro Pro Leu Leu  Ile Ala Lys 
    1820                 1825                 1830             


Pro Asn  Lys Val Gln Leu Ile  Ala Met Asp Leu Pro  Met Val Ser 
    1835                 1840                 1845             


Gly Asp  Arg Ile His Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys 
    1850                 1855                 1860             


Arg Val  Leu Gly Glu Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln 
    1865                 1870                 1875             


Met Glu  Glu Arg Phe Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr 
    1880                 1885                 1890             


Glu Pro  Ile Thr Thr Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser 
    1895                 1900                 1905             


Ala Ile  Ile Ile Gln Arg Ala  Tyr Arg Arg Tyr Leu  Leu Lys Gln 
    1910                 1915                 1920             


Lys Val  Lys Lys Val Ser Ser  Ile Tyr Lys Lys Asp  Lys Gly Lys 
    1925                 1930                 1935             


Glu Cys  Asp Gly Thr Pro Ile  Lys Glu Asp Thr Leu  Ile Asp Lys 
    1940                 1945                 1950             


Leu Asn  Glu Asn Ser Thr Pro  Glu Lys Thr Asp Met  Thr Pro Ser 
    1955                 1960                 1965             


Thr Thr  Ser Pro Pro Ser Tyr  Asp Ser Val Thr Lys  Pro Glu Lys 
    1970                 1975                 1980             


Glu Lys  Phe Glu Lys Asp Lys  Ser Glu Lys Glu Asp  Lys Gly Lys 
    1985                 1990                 1995             


Asp Ile  Arg Glu Ser Lys Lys  Lys Val Pro Val Phe  Thr Leu Glu 
    2000                 2005                 2010             


Asp Phe  Val Gly Asp Trp Arg  Gln Thr Ala Gly Tyr  Asn Leu Asp 
    2015                 2020                 2025             


Gln Val  Leu Glu Gln Gly Gly  Val Ser Ser Leu Phe  Gln Asn Leu 
    2030                 2035                 2040             


Gly Val  Ser Val Thr Pro Ile  Gln Arg Ile Val Leu  Ser Gly Glu 
    2045                 2050                 2055             


Asn Gly  Leu Lys Ile Asp Ile  His Val Ile Ile Pro  Tyr Glu Gly 
    2060                 2065                 2070             


Leu Ser  Gly Asp Gln Met Gly  Gln Ile Glu Lys Ile  Phe Lys Val 
    2075                 2080                 2085             


Val Tyr  Pro Val Asp Asp His  His Phe Lys Val Ile  Leu His Tyr 
    2090                 2095                 2100             


Gly Thr  Leu Val Ile Asp Gly  Val Thr Pro Asn Met  Ile Asp Tyr 
    2105                 2110                 2115             


Phe Gly  Arg Pro Tyr Glu Gly  Ile Ala Val Phe Asp  Gly Lys Lys 
    2120                 2125                 2130             


Ile Thr  Val Thr Gly Thr Leu  Trp Asn Gly Asn Lys  Ile Ile Asp 
    2135                 2140                 2145             


Glu Arg  Leu Ile Asn Pro Asp  Gly Ser Leu Leu Phe  Arg Val Thr 
    2150                 2155                 2160             


Ile Asn  Gly Val Thr Gly Trp  Arg Leu Cys Glu Arg  Ile Leu Ala 
    2165                 2170                 2175             


Gly Gly  Gly Gly Ser Pro Ser  Arg Leu Glu Glu Glu  Leu Arg Arg 
    2180                 2185                 2190             


Arg Leu  Thr Glu Pro 
    2195             


<210> 438
<211> 2202
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 438
Met Glu Gln Thr Val Leu Val Pro Pro Gly Pro Asp Ser Phe Asn Phe 
1               5                   10                  15      


Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Arg Arg Ile Ala Glu Glu 
            20                  25                  30          


Lys Ala Lys Asn Pro Lys Pro Asp Lys Lys Asp Asp Asp Glu Asn Gly 
        35                  40                  45              


Pro Lys Pro Asn Ser Asp Leu Glu Ala Gly Lys Asn Leu Pro Phe Ile 
    50                  55                  60                  


Tyr Gly Asp Ile Pro Pro Glu Met Val Ser Glu Pro Leu Glu Asp Leu 
65                  70                  75                  80  


Asp Pro Tyr Tyr Ile Asn Lys Lys Thr Phe Ile Val Leu Asn Lys Gly 
                85                  90                  95      


Lys Ala Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 
            100                 105                 110         


Pro Phe Asn Pro Leu Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 
        115                 120                 125             


Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val Phe 
    130                 135                 140                 


Met Thr Met Ser Asn Pro Pro Asp Trp Thr Lys Asn Val Glu Tyr Thr 
145                 150                 155                 160 


Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu Ile Lys Ile Ile Ala Arg 
                165                 170                 175     


Gly Phe Cys Leu Glu Asp Phe Thr Phe Leu Arg Asp Pro Trp Asn Trp 
            180                 185                 190         


Leu Asp Phe Thr Val Ile Thr Phe Ala Tyr Val Thr Glu Phe Val Asp 
        195                 200                 205             


Leu Gly Asn Val Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 
    210                 215                 220                 


Lys Thr Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 
225                 230                 235                 240 


Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe 
                245                 250                 255     


Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met Gly Asn 
            260                 265                 270         


Leu Arg Asn Lys Cys Ile Gln Trp Pro Pro Thr Asn Ala Ser Leu Glu 
        275                 280                 285             


Glu His Ser Ile Glu Lys Asn Ile Thr Val Asn Tyr Asn Gly Thr Leu 
    290                 295                 300                 


Ile Asn Glu Thr Val Phe Glu Phe Asp Trp Lys Ser Tyr Ile Gln Asp 
305                 310                 315                 320 


Ser Arg Tyr His Tyr Phe Leu Glu Gly Phe Leu Asp Ala Leu Leu Cys 
                325                 330                 335     


Gly Asn Ser Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Met Cys Val 
            340                 345                 350         


Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr Phe 
        355                 360                 365             


Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Phe Trp 
    370                 375                 380                 


Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys Thr Tyr Met 
385                 390                 395                 400 


Ile Phe Phe Val Leu Val Ile Phe Leu Gly Ser Phe Tyr Leu Ile Asn 
                405                 410                 415     


Leu Ile Leu Ala Val Val Ala Met Ala Tyr Glu Glu Gln Asn Gln Ala 
            420                 425                 430         


Thr Leu Glu Glu Ala Glu Gln Lys Glu Ala Glu Phe Gln Gln Met Ile 
        435                 440                 445             


Glu Gln Leu Lys Lys Gln Gln Glu Ala Ala Gln Gln Ala Ala Thr Ala 
    450                 455                 460                 


Thr Ala Ser Glu His Ser Arg Glu Pro Ser Ala Ala Gly Arg Leu Ser 
465                 470                 475                 480 


Asp Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala Lys Glu 
                485                 490                 495     


Arg Arg Asn Arg Arg Lys Lys Arg Lys Gln Lys Glu Gln Ser Gly Gly 
            500                 505                 510         


Glu Glu Lys Asp Glu Asp Glu Phe Gln Lys Ser Glu Ser Glu Asp Ser 
        515                 520                 525             


Ile Arg Arg Lys Gly Phe Arg Phe Ser Ile Glu Gly Asn Arg Leu Thr 
    530                 535                 540                 


Tyr Glu Lys Arg Tyr Ser Ser Pro His Gln Ser Leu Leu Ser Ile Arg 
545                 550                 555                 560 


Gly Ser Leu Phe Ser Pro Arg Arg Asn Ser Arg Thr Ser Leu Phe Ser 
                565                 570                 575     


Phe Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp Phe Ala Asp 
            580                 585                 590         


Asp Glu His Ser Thr Phe Glu Asp Asn Glu Ser Arg Arg Asp Ser Leu 
        595                 600                 605             


Phe Val Pro Arg Arg His Gly Glu Arg Arg Asn Ser Asn Leu Ser Gln 
    610                 615                 620                 


Thr Ser Arg Ser Ser Arg Met Leu Ala Val Phe Pro Ala Asn Gly Lys 
625                 630                 635                 640 


Met His Ser Thr Val Asp Cys Asn Gly Val Val Ser Leu Val Gly Gly 
                645                 650                 655     


Pro Ser Val Pro Thr Ser Pro Val Gly Gln Leu Leu Pro Glu Val Ile 
            660                 665                 670         


Ile Asp Lys Pro Ala Thr Asp Asp Asn Gly Thr Thr Thr Glu Thr Glu 
        675                 680                 685             


Met Arg Lys Arg Arg Ser Ser Ser Phe His Val Ser Met Asp Phe Leu 
    690                 695                 700                 


Glu Asp Pro Ser Gln Arg Gln Arg Ala Met Ser Ile Ala Ser Ile Leu 
705                 710                 715                 720 


Thr Asn Thr Val Glu Glu Leu Glu Glu Ser Arg Gln Lys Cys Pro Pro 
                725                 730                 735     


Cys Trp Tyr Lys Phe Ser Asn Ile Phe Leu Ile Trp Asp Cys Ser Pro 
            740                 745                 750         


Tyr Trp Leu Lys Val Lys His Val Val Asn Leu Val Val Met Asp Pro 
        755                 760                 765             


Phe Val Asp Leu Ala Ile Thr Ile Cys Ile Val Leu Asn Thr Leu Phe 
    770                 775                 780                 


Met Ala Met Glu His Tyr Pro Met Thr Asp His Phe Asn Asn Val Leu 
785                 790                 795                 800 


Thr Val Gly Asn Leu Val Phe Thr Gly Ile Phe Thr Ala Glu Met Phe 
                805                 810                 815     


Leu Lys Ile Ile Ala Met Asp Pro Tyr Tyr Tyr Phe Gln Glu Gly Trp 
            820                 825                 830         


Asn Ile Phe Asp Gly Phe Ile Val Thr Leu Ser Leu Val Glu Leu Gly 
        835                 840                 845             


Leu Ala Asn Val Glu Gly Leu Ser Val Leu Arg Ser Phe Arg Leu Leu 
    850                 855                 860                 


Arg Val Phe Lys Leu Ala Lys Ser Trp Pro Thr Leu Asn Met Leu Ile 
865                 870                 875                 880 


Lys Ile Ile Gly Asn Ser Val Gly Ala Leu Gly Asn Leu Thr Leu Val 
                885                 890                 895     


Leu Ala Ile Ile Val Phe Ile Phe Ala Val Val Gly Met Gln Leu Phe 
            900                 905                 910         


Gly Lys Ser Tyr Lys Asp Cys Val Cys Lys Ile Ala Ser Asp Cys Gln 
        915                 920                 925             


Leu Pro Arg Trp His Met Asn Asp Phe Phe His Ser Phe Leu Ile Val 
    930                 935                 940                 


Phe Arg Val Leu Cys Gly Glu Trp Ile Glu Thr Met Trp Asp Cys Met 
945                 950                 955                 960 


Glu Val Ala Gly Gln Ala Met Cys Leu Thr Val Phe Met Met Val Met 
                965                 970                 975     


Val Ile Gly Asn Leu Val Val Leu Asn Leu Phe Leu Ala Leu Leu Leu 
            980                 985                 990         


Ser Ser Phe Ser Ala Asp Asn Leu  Ala Ala Thr Asp Asp  Asp Asn Glu 
        995                 1000                 1005             


Met Asn  Asn Leu Gln Ile Ala  Val Asp Arg Met His  Lys Gly Val 
    1010                 1015                 1020             


Ala Tyr  Val Lys Arg Lys Ile  Tyr Glu Phe Ile Gln  Gln Ser Phe 
    1025                 1030                 1035             


Ile Arg  Lys Gln Lys Ile Leu  Asp Glu Ile Lys Pro  Leu Asp Asp 
    1040                 1045                 1050             


Leu Asn  Asn Lys Lys Asp Ser  Cys Met Ser Asn His  Thr Ala Glu 
    1055                 1060                 1065             


Ile Gly  Lys Asp Leu Asp Tyr  Leu Lys Asp Val Asn  Gly Thr Thr 
    1070                 1075                 1080             


Ser Gly  Ile Gly Thr Gly Ser  Ser Val Glu Lys Tyr  Ile Ile Asp 
    1085                 1090                 1095             


Glu Ser  Asp Tyr Met Ser Phe  Ile Asn Asn Pro Ser  Leu Thr Val 
    1100                 1105                 1110             


Thr Val  Pro Ile Ala Val Gly  Glu Ser Asp Phe Glu  Asn Leu Asn 
    1115                 1120                 1125             


Thr Glu  Asp Phe Ser Ser Glu  Ser Asp Leu Glu Glu  Ser Lys Glu 
    1130                 1135                 1140             


Lys Leu  Asn Glu Ser Ser Ser  Ser Ser Glu Gly Ser  Thr Val Asp 
    1145                 1150                 1155             


Ile Gly  Ala Pro Val Glu Glu  Gln Pro Val Val Glu  Pro Glu Glu 
    1160                 1165                 1170             


Thr Leu  Glu Pro Glu Ala Cys  Phe Thr Glu Gly Cys  Val Gln Arg 
    1175                 1180                 1185             


Phe Lys  Cys Cys Gln Ile Asn  Val Glu Glu Gly Arg  Gly Lys Gln 
    1190                 1195                 1200             


Trp Trp  Asn Leu Arg Arg Thr  Cys Phe Arg Ile Val  Glu His Asn 
    1205                 1210                 1215             


Trp Phe  Glu Thr Phe Ile Val  Phe Met Ile Leu Leu  Ser Ser Gly 
    1220                 1225                 1230             


Ala Leu  Ala Phe Glu Asp Ile  Tyr Ile Asp Gln Arg  Lys Thr Ile 
    1235                 1240                 1245             


Lys Thr  Met Leu Glu Tyr Ala  Asp Lys Val Phe Thr  Tyr Ile Phe 
    1250                 1255                 1260             


Ile Leu  Glu Met Leu Leu Lys  Trp Val Ala Tyr Gly  Tyr Gln Thr 
    1265                 1270                 1275             


Tyr Phe  Thr Asn Ala Trp Cys  Trp Leu Asp Phe Leu  Ile Val Asp 
    1280                 1285                 1290             


Val Ser  Leu Val Ser Leu Thr  Ala Asn Ala Leu Gly  Tyr Ser Glu 
    1295                 1300                 1305             


Leu Gly  Ala Ile Lys Ser Leu  Arg Thr Leu Arg Ala  Leu Arg Pro 
    1310                 1315                 1320             


Leu Arg  Ala Leu Ser Arg Phe  Glu Gly Met Arg Val  Val Val Asn 
    1325                 1330                 1335             


Ala Leu  Leu Gly Ala Ile Pro  Ser Ile Met Asn Val  Leu Leu Val 
    1340                 1345                 1350             


Cys Leu  Ile Phe Trp Leu Ile  Phe Ser Ile Met Gly  Val Asn Leu 
    1355                 1360                 1365             


Phe Ala  Gly Lys Phe Tyr His  Cys Ile Asn Thr Thr  Thr Gly Asp 
    1370                 1375                 1380             


Arg Phe  Asp Ile Glu Asp Val  Asn Asn His Thr Asp  Cys Leu Lys 
    1385                 1390                 1395             


Leu Ile  Glu Arg Asn Glu Thr  Ala Arg Trp Lys Asn  Val Lys Val 
    1400                 1405                 1410             


Asn Phe  Asp Asn Val Gly Phe  Gly Tyr Leu Ser Leu  Leu Gln Val 
    1415                 1420                 1425             


Ala Thr  Phe Lys Gly Trp Met  Asp Ile Met Tyr Ala  Ala Val Asp 
    1430                 1435                 1440             


Ser Arg  Asn Val Glu Leu Gln  Pro Lys Tyr Glu Glu  Ser Leu Tyr 
    1445                 1450                 1455             


Met Tyr  Leu Tyr Phe Val Ile  Phe Ile Ile Phe Gly  Ser Phe Phe 
    1460                 1465                 1470             


Thr Leu  Asn Leu Phe Ile Gly  Val Ile Ile Asp Asn  Phe Asn Gln 
    1475                 1480                 1485             


Gln Lys  Lys Lys Phe Gly Gly  Gln Asp Ile Phe Met  Thr Glu Glu 
    1490                 1495                 1500             


Gln Lys  Lys Tyr Tyr Asn Ala  Met Lys Lys Leu Gly  Ser Lys Lys 
    1505                 1510                 1515             


Pro Gln  Lys Pro Ile Pro Arg  Pro Gly Asn Lys Phe  Gln Gly Met 
    1520                 1525                 1530             


Val Phe  Asp Phe Val Thr Arg  Gln Val Phe Asp Ile  Ser Ile Met 
    1535                 1540                 1545             


Ile Leu  Ile Cys Leu Asn Met  Val Thr Met Met Val  Glu Thr Asp 
    1550                 1555                 1560             


Asp Gln  Ser Glu Tyr Val Thr  Thr Ile Leu Ser Arg  Ile Asn Leu 
    1565                 1570                 1575             


Val Phe  Ile Val Leu Phe Thr  Gly Glu Cys Val Leu  Lys Leu Ile 
    1580                 1585                 1590             


Ser Leu  Arg His Tyr Tyr Phe  Thr Ile Gly Trp Asn  Ile Phe Asp 
    1595                 1600                 1605             


Phe Val  Val Val Ile Leu Ser  Ile Val Gly Met Phe  Leu Ala Glu 
    1610                 1615                 1620             


Leu Ile  Glu Lys Tyr Phe Val  Ser Pro Thr Leu Phe  Arg Val Ile 
    1625                 1630                 1635             


Arg Leu  Ala Arg Ile Gly Arg  Ile Leu Arg Leu Ile  Lys Gly Ala 
    1640                 1645                 1650             


Lys Gly  Ile Arg Thr Leu Leu  Phe Ala Leu Met Met  Ser Leu Pro 
    1655                 1660                 1665             


Ala Leu  Phe Asn Ile Gly Leu  Leu Leu Phe Leu Val  Met Phe Ile 
    1670                 1675                 1680             


Tyr Ala  Ile Phe Gly Met Ser  Asn Phe Ala Tyr Val  Lys Arg Glu 
    1685                 1690                 1695             


Val Gly  Ile Asp Asp Met Phe  Asn Phe Glu Thr Phe  Gly Asn Ser 
    1700                 1705                 1710             


Met Ile  Cys Leu Phe Gln Ile  Thr Thr Ser Ala Gly  Trp Asp Gly 
    1715                 1720                 1725             


Leu Leu  Ala Pro Ile Leu Asn  Ser Lys Pro Pro Asp  Cys Asp Pro 
    1730                 1735                 1740             


Asn Lys  Val Asn Pro Gly Ser  Ser Val Lys Gly Asp  Cys Gly Asn 
    1745                 1750                 1755             


Pro Ser  Val Gly Ile Phe Phe  Phe Val Ser Tyr Ile  Ile Ile Ser 
    1760                 1765                 1770             


Phe Leu  Val Val Val Asn Met  Tyr Ile Ala Val Ile  Leu Glu Asn 
    1775                 1780                 1785             


Phe Ser  Val Ala Thr Glu Glu  Ser Ala Glu Pro Leu  Ser Glu Asp 
    1790                 1795                 1800             


Asp Phe  Glu Met Phe Tyr Glu  Val Trp Glu Lys Phe  Asp Pro Asp 
    1805                 1810                 1815             


Ala Thr  Gln Phe Met Glu Phe  Glu Lys Leu Ser Gln  Phe Ala Ala 
    1820                 1825                 1830             


Ala Leu  Glu Pro Pro Leu Asn  Leu Pro Gln Pro Asn  Lys Leu Gln 
    1835                 1840                 1845             


Leu Ile  Ala Met Asp Leu Pro  Met Val Ser Gly Asp  Arg Ile His 
    1850                 1855                 1860             


Cys Leu  Asp Ile Leu Phe Ala  Phe Thr Lys Arg Val  Leu Gly Glu 
    1865                 1870                 1875             


Ser Gly  Glu Met Asp Ala Leu  Arg Ile Gln Met Glu  Glu Arg Phe 
    1880                 1885                 1890             


Met Ala  Ser Asn Pro Ser Lys  Val Ser Tyr Gln Pro  Ile Thr Thr 
    1895                 1900                 1905             


Thr Leu  Lys Arg Lys Gln Glu  Glu Val Ser Ala Val  Ile Ile Gln 
    1910                 1915                 1920             


Arg Ala  Tyr Arg Arg His Leu  Leu Lys Arg Thr Val  Lys Gln Ala 
    1925                 1930                 1935             


Ser Phe  Thr Tyr Asn Lys Asn  Lys Ile Lys Gly Gly  Ala Asn Leu 
    1940                 1945                 1950             


Leu Ile  Lys Glu Asp Met Ile  Ile Asp Arg Ile Asn  Glu Asn Ser 
    1955                 1960                 1965             


Ile Thr  Glu Lys Thr Asp Leu  Thr Met Ser Thr Ala  Ala Cys Pro 
    1970                 1975                 1980             


Pro Ser  Tyr Asp Arg Val Thr  Lys Pro Ile Val Glu  Lys His Glu 
    1985                 1990                 1995             


Gln Glu  Gly Lys Asp Glu Lys  Ala Lys Gly Lys Lys  Val Pro Val 
    2000                 2005                 2010             


Phe Thr  Leu Glu Asp Phe Val  Gly Asp Trp Arg Gln  Thr Ala Gly 
    2015                 2020                 2025             


Tyr Asn  Leu Asp Gln Val Leu  Glu Gln Gly Gly Val  Ser Ser Leu 
    2030                 2035                 2040             


Phe Gln  Asn Leu Gly Val Ser  Val Thr Pro Ile Gln  Arg Ile Val 
    2045                 2050                 2055             


Leu Ser  Gly Glu Asn Gly Leu  Lys Ile Asp Ile His  Val Ile Ile 
    2060                 2065                 2070             


Pro Tyr  Glu Gly Leu Ser Gly  Asp Gln Met Gly Gln  Ile Glu Lys 
    2075                 2080                 2085             


Ile Phe  Lys Val Val Tyr Pro  Val Asp Asp His His  Phe Lys Val 
    2090                 2095                 2100             


Ile Leu  His Tyr Gly Thr Leu  Val Ile Asp Gly Val  Thr Pro Asn 
    2105                 2110                 2115             


Met Ile  Asp Tyr Phe Gly Arg  Pro Tyr Glu Gly Ile  Ala Val Phe 
    2120                 2125                 2130             


Asp Gly  Lys Lys Ile Thr Val  Thr Gly Thr Leu Trp  Asn Gly Asn 
    2135                 2140                 2145             


Lys Ile  Ile Asp Glu Arg Leu  Ile Asn Pro Asp Gly  Ser Leu Leu 
    2150                 2155                 2160             


Phe Arg  Val Thr Ile Asn Gly  Val Thr Gly Trp Arg  Leu Cys Glu 
    2165                 2170                 2175             


Arg Ile  Leu Ala Gly Gly Gly  Gly Ser Pro Ser Arg  Leu Glu Glu 
    2180                 2185                 2190             


Glu Leu  Arg Arg Arg Leu Thr  Glu Pro 
    2195                 2200         


<210> 439
<211> 1677
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 439
Met Lys Pro Arg Ala Glu Cys Cys Ser Pro Lys Phe Trp Leu Val Leu 
1               5                   10                  15      


Ala Val Leu Ala Val Ser Gly Ser Arg Ala Arg Ser Gln Lys Ser Pro 
            20                  25                  30          


Pro Ser Ile Gly Ile Ala Val Ile Leu Val Gly Thr Ser Asp Glu Val 
        35                  40                  45              


Ala Ile Lys Asp Ala His Glu Lys Asp Asp Phe His His Leu Ser Val 
    50                  55                  60                  


Val Pro Arg Val Glu Leu Val Ala Met Asn Glu Thr Asp Pro Lys Ser 
65                  70                  75                  80  


Ile Ile Thr Arg Ile Cys Asp Leu Met Ser Asp Arg Lys Ile Gln Gly 
                85                  90                  95      


Val Val Phe Ala Asp Asp Thr Asp Gln Glu Ala Ile Ala Gln Ile Leu 
            100                 105                 110         


Asp Phe Ile Ser Ala Gln Thr Leu Thr Pro Ile Leu Gly Ile His Gly 
        115                 120                 125             


Gly Ser Ser Met Ile Met Ala Asp Lys Asp Glu Ser Ser Met Phe Phe 
    130                 135                 140                 


Gln Phe Gly Pro Ser Ile Glu Gln Gln Ala Ser Val Met Leu Asn Ile 
145                 150                 155                 160 


Met Glu Glu Tyr Asp Trp Tyr Ile Phe Ser Ile Val Thr Thr Tyr Phe 
                165                 170                 175     


Pro Gly Tyr Gln Asp Phe Val Asn Lys Ile Arg Ser Thr Ile Glu Asn 
            180                 185                 190         


Ser Phe Val Gly Trp Glu Leu Glu Glu Val Leu Leu Leu Asp Met Ser 
        195                 200                 205             


Leu Asp Asp Gly Asp Ser Lys Ile Gln Asn Gln Leu Lys Lys Leu Gln 
    210                 215                 220                 


Ser Pro Ile Ile Leu Leu Tyr Cys Thr Lys Glu Glu Ala Thr Tyr Ile 
225                 230                 235                 240 


Phe Glu Val Ala Asn Ser Val Gly Leu Thr Gly Tyr Gly Tyr Thr Trp 
                245                 250                 255     


Ile Val Pro Ser Leu Val Ala Gly Asp Thr Asp Thr Val Pro Ala Glu 
            260                 265                 270         


Phe Pro Thr Gly Leu Ile Ser Val Ser Tyr Asp Glu Trp Asp Tyr Gly 
        275                 280                 285             


Leu Pro Ala Arg Val Arg Asp Gly Ile Ala Ile Ile Thr Thr Ala Ala 
    290                 295                 300                 


Ser Asp Met Leu Ser Glu His Ser Phe Ile Pro Glu Pro Lys Ser Ser 
305                 310                 315                 320 


Cys Tyr Asn Thr His Glu Lys Arg Ile Tyr Gln Ser Asn Met Leu Asn 
                325                 330                 335     


Arg Tyr Leu Ile Asn Val Thr Phe Glu Gly Arg Asn Leu Ser Phe Ser 
            340                 345                 350         


Glu Asp Gly Tyr Gln Met His Pro Lys Leu Val Ile Ile Leu Leu Asn 
        355                 360                 365             


Lys Glu Arg Lys Trp Glu Arg Val Gly Lys Trp Lys Asp Lys Ser Leu 
    370                 375                 380                 


Gln Met Lys Tyr Tyr Val Trp Pro Arg Met Cys Pro Glu Thr Glu Glu 
385                 390                 395                 400 


Gln Glu Asp Asp His Leu Ser Ile Val Thr Leu Glu Glu Ala Pro Phe 
                405                 410                 415     


Val Ile Val Glu Ser Val Asp Pro Leu Ser Gly Thr Cys Met Arg Asn 
            420                 425                 430         


Thr Val Pro Cys Gln Lys Arg Ile Val Thr Glu Asn Lys Thr Asp Glu 
        435                 440                 445             


Glu Pro Gly Tyr Ile Lys Lys Cys Cys Lys Gly Phe Cys Ile Asp Ile 
    450                 455                 460                 


Leu Lys Lys Ile Ser Lys Ser Val Lys Phe Thr Tyr Asp Leu Tyr Leu 
465                 470                 475                 480 


Val Thr Asn Gly Lys His Gly Lys Lys Ile Asn Gly Thr Trp Asn Gly 
                485                 490                 495     


Met Ile Gly Glu Val Val Met Lys Arg Ala Tyr Met Ala Val Gly Ser 
            500                 505                 510         


Leu Thr Ile Asn Glu Glu Arg Ser Glu Val Val Asp Phe Ser Val Pro 
        515                 520                 525             


Phe Ile Glu Thr Gly Ile Ser Val Met Val Ser Arg Ser Asn Gly Thr 
    530                 535                 540                 


Val Ser Pro Ser Ala Phe Leu Glu Pro Phe Ser Ala Asp Val Trp Val 
545                 550                 555                 560 


Met Met Phe Val Met Leu Leu Ile Val Ser Ala Val Ala Val Phe Val 
                565                 570                 575     


Phe Glu Tyr Phe Ser Pro Val Gly Tyr Asn Arg Cys Leu Ala Asp Gly 
            580                 585                 590         


Arg Glu Pro Gly Gly Pro Ser Phe Thr Ile Gly Lys Ala Ile Trp Leu 
        595                 600                 605             


Leu Trp Gly Leu Val Phe Asn Asn Ser Val Pro Val Gln Asn Pro Lys 
    610                 615                 620                 


Gly Thr Thr Ser Lys Ile Met Val Ser Val Trp Ala Phe Phe Ala Val 
625                 630                 635                 640 


Ile Phe Leu Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Met Ile Gln 
                645                 650                 655     


Glu Glu Tyr Val Asp Gln Val Ser Gly Leu Ser Asp Lys Lys Phe Gln 
            660                 665                 670         


Arg Pro Asn Asp Phe Ser Pro Pro Phe Arg Phe Gly Thr Val Pro Asn 
        675                 680                 685             


Gly Ser Thr Glu Arg Asn Ile Arg Asn Asn Tyr Ala Glu Met His Ala 
    690                 695                 700                 


Tyr Met Gly Lys Phe Asn Gln Arg Gly Val Asp Asp Ala Leu Leu Ser 
705                 710                 715                 720 


Leu Lys Thr Gly Lys Leu Asp Ala Phe Ile Tyr Asp Ala Ala Val Leu 
                725                 730                 735     


Asn Tyr Met Ala Gly Arg Asp Glu Gly Cys Lys Leu Val Thr Ile Gly 
            740                 745                 750         


Ser Gly Lys Val Phe Ala Ser Thr Gly Tyr Gly Ile Ala Ile Gln Lys 
        755                 760                 765             


Asp Ser Gly Trp Lys Arg Gln Val Asp Leu Ala Ile Leu Gln Leu Phe 
    770                 775                 780                 


Gly Asp Gly Glu Met Glu Glu Leu Glu Ala Leu Trp Leu Thr Gly Ile 
785                 790                 795                 800 


Cys His Asn Glu Lys Asn Glu Val Met Ser Ser Gln Leu Asp Ile Asp 
                805                 810                 815     


Asn Met Ala Gly Val Phe Tyr Met Leu Gly Ala Ala Met Ala Leu Ser 
            820                 825                 830         


Leu Ile Thr Phe Ile Cys Glu His Leu Phe Tyr Trp Gln Phe Arg His 
        835                 840                 845             


Cys Phe Met Gly Val Cys Ser Gly Lys Pro Gly Met Val Phe Ser Ile 
    850                 855                 860                 


Ser Arg Gly Ile Tyr Ser Cys Ile His Gly Val Ala Ile Glu Glu Arg 
865                 870                 875                 880 


Gln Ser Val Met Asn Ser Pro Thr Ala Thr Met Asn Asn Thr His Ser 
                885                 890                 895     


Asn Ile Leu Arg Leu Leu Arg Thr Ala Lys Asn Met Ala Asn Leu Ser 
            900                 905                 910         


Gly Val Asn Gly Ser Pro Gln Ser Ala Leu Asp Phe Ile Arg Arg Glu 
        915                 920                 925             


Ser Ser Val Tyr Asp Ile Ser Glu His Arg Arg Ser Phe Thr His Ser 
    930                 935                 940                 


Asp Cys Lys Ser Tyr Asn Asn Pro Pro Cys Glu Glu Asn Leu Phe Ser 
945                 950                 955                 960 


Asp Tyr Ile Ser Glu Val Glu Arg Thr Phe Gly Asn Leu Gln Leu Lys 
                965                 970                 975     


Asp Ser Asn Val Tyr Gln Asp His Tyr His His His His Arg Pro His 
            980                 985                 990         


Ser Ile Gly Ser Ala Ser Ser Ile  Asp Gly Leu Tyr Asp  Cys Asp Asn 
        995                 1000                 1005             


Pro Pro  Phe Thr Thr Gln Ser  Arg Ser Ile Ser Lys  Lys Pro Leu 
    1010                 1015                 1020             


Asp Ile  Gly Leu Pro Ser Ser  Lys His Ser Gln Leu  Ser Asp Leu 
    1025                 1030                 1035             


Tyr Gly  Lys Phe Ser Phe Lys  Ser Asp Arg Tyr Ser  Gly His Asp 
    1040                 1045                 1050             


Asp Leu  Ile Arg Ser Asp Val  Ser Asp Ile Ser Thr  His Thr Val 
    1055                 1060                 1065             


Thr Tyr  Gly Asn Ile Glu Gly  Asn Ala Ala Lys Arg  Arg Lys Gln 
    1070                 1075                 1080             


Gln Tyr  Lys Asp Ser Leu Lys  Lys Arg Pro Ala Ser  Ala Lys Ser 
    1085                 1090                 1095             


Arg Arg  Glu Phe Asp Glu Ile  Glu Leu Ala Tyr Arg  Arg Arg Pro 
    1100                 1105                 1110             


Pro Arg  Ser Pro Asp His Lys  Arg Tyr Phe Arg Asp  Lys Glu Gly 
    1115                 1120                 1125             


Leu Arg  Asp Phe Tyr Leu Asp  Gln Phe Arg Thr Lys  Glu Asn Ser 
    1130                 1135                 1140             


Pro His  Trp Glu His Val Asp  Leu Thr Asp Ile Tyr  Lys Glu Arg 
    1145                 1150                 1155             


Ser Asp  Asp Phe Lys Arg Asp  Ser Val Ser Gly Gly  Gly Pro Cys 
    1160                 1165                 1170             


Thr Asn  Arg Ser His Ile Lys  His Gly Thr Gly Asp  Lys His Gly 
    1175                 1180                 1185             


Val Val  Ser Gly Val Pro Ala  Pro Trp Glu Lys Asn  Leu Thr Asn 
    1190                 1195                 1200             


Val Glu  Trp Glu Asp Arg Ser  Gly Gly Asn Phe Cys  Arg Ser Cys 
    1205                 1210                 1215             


Pro Ser  Lys Leu His Asn Tyr  Ser Thr Thr Val Thr  Gly Gln Asn 
    1220                 1225                 1230             


Ser Gly  Arg Gln Ala Cys Ile  Arg Cys Glu Ala Cys  Lys Lys Ala 
    1235                 1240                 1245             


Gly Asn  Leu Tyr Asp Ile Ser  Glu Asp Asn Ser Leu  Gln Glu Leu 
    1250                 1255                 1260             


Asp Gln  Pro Ala Ala Pro Val  Ala Val Thr Ser Asn  Ala Ser Thr 
    1265                 1270                 1275             


Thr Lys  Tyr Pro Gln Ser Pro  Thr Asn Ser Lys Ala  Gln Lys Lys 
    1280                 1285                 1290             


Asn Arg  Asn Lys Leu Arg Arg  Gln His Ser Tyr Asp  Thr Phe Val 
    1295                 1300                 1305             


Asp Leu  Gln Lys Glu Glu Ala  Ala Leu Ala Pro Arg  Ser Val Ser 
    1310                 1315                 1320             


Leu Lys  Asp Lys Gly Arg Phe  Met Asp Gly Ser Pro  Tyr Ala His 
    1325                 1330                 1335             


Met Phe  Glu Met Ser Ala Gly  Glu Ser Thr Phe Ala  Asn Asn Lys 
    1340                 1345                 1350             


Ser Ser  Val Pro Thr Ala Gly  His His His His Asn  Asn Pro Gly 
    1355                 1360                 1365             


Gly Gly  Tyr Met Leu Ser Lys  Ser Leu Tyr Pro Asp  Arg Val Thr 
    1370                 1375                 1380             


Gln Asn  Pro Phe Ile Pro Thr  Phe Gly Asp Asp Gln  Cys Leu Leu 
    1385                 1390                 1395             


His Gly  Ser Lys Ser Tyr Phe  Phe Arg Gln Pro Thr  Val Ala Gly 
    1400                 1405                 1410             


Ala Ser  Lys Ala Arg Pro Asp  Phe Arg Ala Leu Val  Thr Asn Lys 
    1415                 1420                 1425             


Pro Val  Val Ser Ala Leu His  Gly Ala Val Pro Ala  Arg Phe Gln 
    1430                 1435                 1440             


Lys Asp  Ile Cys Ile Gly Asn  Gln Ser Asn Pro Cys  Val Pro Asn 
    1445                 1450                 1455             


Asn Lys  Asn Pro Arg Ala Phe  Asn Gly Ser Ser Asn  Gly His Val 
    1460                 1465                 1470             


Tyr Glu  Lys Leu Ser Ser Ile  Glu Ser Asp Val Lys  Val Pro Val 
    1475                 1480                 1485             


Phe Thr  Leu Glu Asp Phe Val  Gly Asp Trp Arg Gln  Thr Ala Gly 
    1490                 1495                 1500             


Tyr Asn  Leu Asp Gln Val Leu  Glu Gln Gly Gly Val  Ser Ser Leu 
    1505                 1510                 1515             


Phe Gln  Asn Leu Gly Val Ser  Val Thr Pro Ile Gln  Arg Ile Val 
    1520                 1525                 1530             


Leu Ser  Gly Glu Asn Gly Leu  Lys Ile Asp Ile His  Val Ile Ile 
    1535                 1540                 1545             


Pro Tyr  Glu Gly Leu Ser Gly  Asp Gln Met Gly Gln  Ile Glu Lys 
    1550                 1555                 1560             


Ile Phe  Lys Val Val Tyr Pro  Val Asp Asp His His  Phe Lys Val 
    1565                 1570                 1575             


Ile Leu  His Tyr Gly Thr Leu  Val Ile Asp Gly Val  Thr Pro Asn 
    1580                 1585                 1590             


Met Ile  Asp Tyr Phe Gly Arg  Pro Tyr Glu Gly Ile  Ala Val Phe 
    1595                 1600                 1605             


Asp Gly  Lys Lys Ile Thr Val  Thr Gly Thr Leu Trp  Asn Gly Asn 
    1610                 1615                 1620             


Lys Ile  Ile Asp Glu Arg Leu  Ile Asn Pro Asp Gly  Ser Leu Leu 
    1625                 1630                 1635             


Phe Arg  Val Thr Ile Asn Gly  Val Thr Gly Trp Arg  Leu Cys Glu 
    1640                 1645                 1650             


Arg Ile  Leu Ala Gly Gly Gly  Gly Ser Pro Ser Arg  Leu Glu Glu 
    1655                 1660                 1665             


Glu Leu  Arg Arg Arg Leu Thr  Glu Pro 
    1670                 1675         


<210> 440
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 440
Met Glu Ala Gly Gly Phe Leu Asp Ser Leu Ile Tyr Gly Ala Cys Val 
1               5                   10                  15      


Val Phe Thr Leu Gly Met Phe Ser Ala Gly Leu Ser Asp Leu Arg His 
            20                  25                  30          


Met Arg Met Thr Arg Ser Val Asp Asn Val Gln Phe Leu Pro Phe Leu 
        35                  40                  45              


Thr Thr Glu Val Lys Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val 
    50                  55                  60                  


Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu 
65                  70                  75                  80  


Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr 
                85                  90                  95      


Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp 
            100                 105                 110         


Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly 
        115                 120                 125             


Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His 
    130                 135                 140                 


Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr 
145                 150                 155                 160 


Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val 
                165                 170                 175     


Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn 
            180                 185                 190         


Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe 
        195                 200                 205             


Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile 
    210                 215                 220                 


Leu Ala Gly Gly Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg 
225                 230                 235                 240 


Arg Arg Leu Thr Glu Pro 
                245     


<210> 441
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 441
Met Glu Leu Glu Ala Met Ser Arg Tyr Thr Ser Pro Val Asn Pro Ala 
1               5                   10                  15      


Val Phe Pro His Leu Thr Val Val Leu Leu Ala Ile Gly Met Phe Phe 
            20                  25                  30          


Thr Ala Trp Phe Phe Val Tyr Pro Phe Thr Glu Gln Pro Glu Asp Gln 
        35                  40                  45              


His Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg 
    50                  55                  60                  


Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val 
65                  70                  75                  80  


Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg 
                85                  90                  95      


Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile 
            100                 105                 110         


Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys 
        115                 120                 125             


Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile 
    130                 135                 140                 


Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile 
145                 150                 155                 160 


Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys 
                165                 170                 175     


Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp 
            180                 185                 190         


Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile 
        195                 200                 205             


Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly 
    210                 215                 220                 


Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr 
225                 230                 235                 240 


Glu Pro 
        


<210> 442
<211> 244
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 442
Met Ala Leu Leu Leu Val Ser Leu Leu Ala Phe Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gly Cys His His Arg Ile Cys His Cys Ser Asn Arg Val Phe Leu Cys 
            20                  25                  30          


Gln Glu Ser Lys Val Thr Glu Ile Pro Ser Asp Leu Pro Arg Asn Ala 
        35                  40                  45              


Ile Glu Leu Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp 
    50                  55                  60                  


Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly 
65                  70                  75                  80  


Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile 
                85                  90                  95      


Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His 
            100                 105                 110         


Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile 
        115                 120                 125             


Glu Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys 
    130                 135                 140                 


Val Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn 
145                 150                 155                 160 


Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp 
                165                 170                 175     


Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile 
            180                 185                 190         


Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val 
        195                 200                 205             


Thr Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
    210                 215                 220                 


Gly Gly Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg 
225                 230                 235                 240 


Leu Thr Glu Pro 
                


<210> 443
<211> 706
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 443
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Glu Val Gln Leu Gln Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
        595                 600                 605             


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
    610                 615                 620                 


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
625                 630                 635                 640 


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
                645                 650                 655     


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
            660                 665                 670         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
        675                 680                 685             


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    690                 695                 700                 


Ser Ser 
705     


<210> 444
<211> 976
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 444
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
            580                 585                 590         


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
        595                 600                 605             


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
    610                 615                 620                 


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
625                 630                 635                 640 


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
                645                 650                 655     


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
            660                 665                 670         


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
        675                 680                 685             


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
    690                 695                 700                 


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
705                 710                 715                 720 


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
                725                 730                 735     


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
            740                 745                 750         


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
        755                 760                 765             


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
    770                 775                 780                 


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
785                 790                 795                 800 


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
                805                 810                 815     


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
            820                 825                 830         


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
        835                 840                 845             


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
    850                 855                 860                 


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
865                 870                 875                 880 


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
                885                 890                 895     


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
            900                 905                 910         


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
        915                 920                 925             


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
    930                 935                 940                 


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
945                 950                 955                 960 


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                965                 970                 975     


<210> 445
<211> 1106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 445
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Glu Val Gln Leu Gln Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
        595                 600                 605             


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
    610                 615                 620                 


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
625                 630                 635                 640 


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
                645                 650                 655     


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
            660                 665                 670         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
        675                 680                 685             


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    690                 695                 700                 


Ser Ser Gly Ala Pro Gly Ser Gly Pro Pro Ser Phe Ser Glu Gly Ser 
705                 710                 715                 720 


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
                725                 730                 735     


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
            740                 745                 750         


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
        755                 760                 765             


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
    770                 775                 780                 


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
785                 790                 795                 800 


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
                805                 810                 815     


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
            820                 825                 830         


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
        835                 840                 845             


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
    850                 855                 860                 


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
865                 870                 875                 880 


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
                885                 890                 895     


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
            900                 905                 910         


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
        915                 920                 925             


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
    930                 935                 940                 


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
945                 950                 955                 960 


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
                965                 970                 975     


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
            980                 985                 990         


Gly Ile Tyr Leu Pro Leu Glu Val  Pro Ala Ser Gln Cys  His Arg Ser 
        995                 1000                 1005             


Pro Leu  Val Leu Ala Tyr Asp  Gln Ala His Phe Ser  Ala Leu Val 
    1010                 1015                 1020             


Ser Met  Glu Gln Lys Glu Asn  Thr Lys Glu Gln Ala  Val Ile Pro 
    1025                 1030                 1035             


Leu Thr  Asp Ser Glu Tyr Lys  Leu Leu Pro Leu His  Phe Ala Val 
    1040                 1045                 1050             


Asp Pro  Gly Lys Gly Trp Glu  Trp Gly Lys Asp Asp  Ser Asp Asn 
    1055                 1060                 1065             


Val Arg  Leu Ala Ser Val Ile  Leu Ser Leu Glu Val  Lys Leu His 
    1070                 1075                 1080             


Leu Leu  His Ser Tyr Met Asn  Val Lys Trp Ile Pro  Leu Ser Ser 
    1085                 1090                 1095             


Asp Ala  Gln Ala Pro Leu Ala  Gln 
    1100                 1105     


<210> 446
<211> 882
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 446
Met Ala Ala Ala Ser Ser Pro Pro Arg Ala Glu Arg Lys Arg Trp Gly 
1               5                   10                  15      


Trp Gly Arg Leu Pro Gly Ala Arg Arg Gly Ser Ala Gly Leu Ala Lys 
            20                  25                  30          


Lys Cys Pro Phe Ser Leu Glu Leu Ala Glu Gly Gly Pro Ala Gly Gly 
        35                  40                  45              


Ala Leu Tyr Ala Pro Ile Ala Pro Gly Ala Pro Gly Pro Ala Pro Pro 
    50                  55                  60                  


Ala Ser Pro Ala Ala Pro Ala Ala Pro Pro Val Ala Ser Asp Leu Gly 
65                  70                  75                  80  


Pro Arg Pro Pro Val Ser Leu Asp Pro Arg Val Ser Ile Tyr Ser Thr 
                85                  90                  95      


Arg Arg Pro Val Leu Ala Arg Thr His Val Gln Gly Arg Val Tyr Asn 
            100                 105                 110         


Phe Leu Glu Arg Pro Thr Gly Trp Lys Cys Phe Val Tyr His Phe Ala 
        115                 120                 125             


Val Phe Leu Ile Val Leu Val Cys Leu Ile Phe Ser Val Leu Ser Thr 
    130                 135                 140                 


Ile Glu Gln Tyr Ala Trp Arg Tyr Tyr Glu Ser Ser Leu Glu Pro Tyr 
145                 150                 155                 160 


Pro Asp Ala Leu Ala Thr Gly Thr Leu Phe Trp Met Glu Ile Val Leu 
                165                 170                 175     


Val Val Phe Phe Gly Thr Glu Tyr Val Val Arg Leu Trp Ser Ala Gly 
            180                 185                 190         


Cys Arg Ser Lys Tyr Val Gly Leu Trp Gly Arg Leu Arg Phe Ala Arg 
        195                 200                 205             


Lys Pro Ile Ser Ile Ile Asp Leu Ile Val Val Val Ala Ser Met Val 
    210                 215                 220                 


Val Leu Cys Val Gly Ser Lys Gly Gln Val Phe Ala Thr Ser Ala Ile 
225                 230                 235                 240 


Arg Gly Ile Arg Phe Leu Gln Ile Leu Arg Met Leu His Val Asp Arg 
                245                 250                 255     


Gln Gly Gly Thr Trp Arg Leu Leu Gly Ser Val Val Phe Ile His Arg 
            260                 265                 270         


Gln Glu Leu Ile Thr Thr Leu Tyr Ile Gly Phe Leu Gly Leu Ile Phe 
        275                 280                 285             


Ser Ser Tyr Phe Val Tyr Leu Ala Glu Lys Asp Ala Val Asn Glu Ser 
    290                 295                 300                 


Gly Arg Val Glu Phe Gly Ser Tyr Ala Asp Ala Leu Trp Trp Gly Val 
305                 310                 315                 320 


Val Thr Val Thr Thr Ile Gly Tyr Gly Asp Lys Val Pro Gln Thr Trp 
                325                 330                 335     


Val Gly Lys Thr Ile Ala Ser Cys Phe Ser Val Phe Ala Ile Ser Phe 
            340                 345                 350         


Phe Ala Leu Pro Ala Gly Ile Leu Gly Ser Gly Phe Ala Leu Lys Val 
        355                 360                 365             


Gln Gln Lys Gln Arg Gln Lys His Phe Asn Arg Gln Ile Pro Ala Ala 
    370                 375                 380                 


Ala Ser Leu Ile Gln Thr Ala Trp Arg Cys Tyr Ala Ala Glu Asn Pro 
385                 390                 395                 400 


Asp Ser Ser Thr Trp Lys Ile Tyr Ile Arg Lys Ala Pro Arg Ser His 
                405                 410                 415     


Thr Leu Leu Ser Pro Ser Pro Lys Pro Lys Lys Ser Val Val Val Lys 
            420                 425                 430         


Lys Lys Lys Phe Lys Leu Asp Lys Asp Asn Gly Val Thr Pro Gly Glu 
        435                 440                 445             


Lys Met Leu Thr Val Pro His Ile Thr Cys Asp Pro Pro Glu Glu Arg 
    450                 455                 460                 


Arg Leu Asp His Phe Ser Val Asp Gly Tyr Asp Ser Ser Val Arg Lys 
465                 470                 475                 480 


Ser Pro Thr Leu Leu Glu Val Ser Met Pro His Phe Met Arg Thr Asn 
                485                 490                 495     


Ser Phe Ala Glu Asp Leu Asp Leu Glu Gly Glu Thr Leu Leu Thr Pro 
            500                 505                 510         


Ile Thr His Ile Ser Gln Leu Arg Glu His His Arg Ala Thr Ile Lys 
        515                 520                 525             


Val Ile Arg Arg Met Gln Tyr Phe Val Ala Lys Lys Lys Phe Gln Gln 
    530                 535                 540                 


Ala Arg Lys Pro Tyr Asp Val Arg Asp Val Ile Glu Gln Tyr Ser Gln 
545                 550                 555                 560 


Gly His Leu Asn Leu Met Val Arg Ile Lys Glu Leu Gln Arg Arg Leu 
                565                 570                 575     


Asp Gln Ser Ile Gly Lys Pro Ser Leu Phe Ile Ser Val Ser Glu Lys 
            580                 585                 590         


Ser Lys Asp Arg Gly Ser Asn Thr Ile Gly Ala Arg Leu Asn Arg Val 
        595                 600                 605             


Glu Asp Lys Val Thr Gln Leu Asp Gln Arg Leu Ala Leu Ile Thr Asp 
    610                 615                 620                 


Met Leu His Gln Leu Leu Ser Leu His Gly Gly Ser Thr Pro Gly Ser 
625                 630                 635                 640 


Gly Gly Pro Pro Arg Glu Gly Gly Ala His Ile Thr Gln Pro Cys Gly 
                645                 650                 655     


Ser Gly Gly Ser Val Asp Pro Glu Leu Phe Leu Pro Ser Asn Thr Leu 
            660                 665                 670         


Pro Thr Tyr Glu Gln Leu Thr Val Pro Arg Arg Gly Pro Asp Glu Gly 
        675                 680                 685             


Ser Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg 
    690                 695                 700                 


Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val 
705                 710                 715                 720 


Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg 
                725                 730                 735     


Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile 
            740                 745                 750         


Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys 
        755                 760                 765             


Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile 
    770                 775                 780                 


Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile 
785                 790                 795                 800 


Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys 
                805                 810                 815     


Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp 
            820                 825                 830         


Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile 
        835                 840                 845             


Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly 
    850                 855                 860                 


Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr 
865                 870                 875                 880 


Glu Pro 
        


<210> 447
<211> 530
<212> PRT
<213> Homo sapiens

<400> 447
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Lys Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 448
<211> 483
<212> PRT
<213> Homo sapiens

<400> 448
Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser 
1               5                   10                  15      


Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu Phe Arg Arg Leu Val 
            20                  25                  30          


Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp Leu Pro Arg Asn Gln 
        35                  40                  45              


Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu Leu Arg Tyr Leu Phe 
    50                  55                  60                  


Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val Asp Pro Ser Arg Ala 
65                  70                  75                  80  


Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn Asp Ser Gln Gln Gln 
                85                  90                  95      


Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala 
            100                 105                 110         


Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu Glu Lys Pro Lys Asn 
        115                 120                 125             


Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu Ala Val Gly Val Leu 
    130                 135                 140                 


Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe Gly Gln Tyr Pro Leu 
145                 150                 155                 160 


Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys Leu Glu Ala Ala Met 
                165                 170                 175     


Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu Asn Ser Gly Lys Ser 
            180                 185                 190         


Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro Val Leu Thr Phe Glu 
        195                 200                 205             


Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly Arg Pro Glu Lys Ile 
    210                 215                 220                 


His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr Leu Asp Arg Tyr Met 
225                 230                 235                 240 


His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg Glu Glu Ile Lys Arg 
                245                 250                 255     


Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg Leu Glu Arg Tyr Leu 
            260                 265                 270         


Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu Val Asp Val Leu Gln 
        275                 280                 285             


Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val Cys Thr Ser Pro Val 
    290                 295                 300                 


Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly Ser Ile Pro Ser Gln 
305                 310                 315                 320 


Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala Leu Ser Ser Glu Leu 
                325                 330                 335     


Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile Ser Ser Arg Ser Val 
            340                 345                 350         


Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro Pro Asp Leu Pro Met 
        355                 360                 365             


His Pro Ala Pro Arg His Ile Thr Glu Glu Glu Leu Ser Val Leu Glu 
    370                 375                 380                 


Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu Asn Asp Thr Arg Asp 
385                 390                 395                 400 


Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr Ile Glu Leu Met Tyr 
                405                 410                 415     


Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg Leu His Ala Val Leu 
            420                 425                 430         


Val His Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Phe 
        435                 440                 445             


Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn Asp Ile Ala Val Thr 
    450                 455                 460                 


Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser Phe Gly Gly Tyr Arg 
465                 470                 475                 480 


Asn Ala Ser 
            


