                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> METHODS OF DETERMINING SURFACE GLYCAN DENSITY

<130> 29539-0545WO1

<140> PCT/US2021/058318
<141> 2021-11-05

<150> 63/111,443
<151> 2020-11-09

<160> 40    

<170> PatentIn version 3.5

<210> 1
<211> 107
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
1               5                   10                  15      


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
            20                  25                  30          


Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
        35                  40                  45              


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
    50                  55                  60                  


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
65                  70                  75                  80  


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
                85                  90                  95      


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105         


<210> 2
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe 
1               5                   10                  15      


Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu 
            20                  25                  30          


Asp Gly Lys Lys Val Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys 
        35                  40                  45              


Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val 
    50                  55                  60                  


Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp 
65                  70                  75                  80  


Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala 
                85                  90                  95      


Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
            100                 105             


<210> 3
<211> 34
<212> PRT
<213> Saccharomyces cerevisiae

<400> 3
Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Ser Ser Asp Thr Ile Asp Asn Val Lys Ser Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu 
        


<210> 4
<211> 42
<212> PRT
<213> Saccharomyces cerevisiae

<400> 4
Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu 
1               5                   10                  15      


Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr 
            20                  25                  30          


Leu His Leu Val Leu Arg Leu Arg Gly Gly 
        35                  40          


<210> 5
<211> 93
<212> PRT
<213> Gaussia princeps

<400> 5
Met Lys Pro Thr Glu Asn Asn Glu Asp Phe Asn Ile Val Ala Val Ala 
1               5                   10                  15      


Ser Asn Phe Ala Thr Thr Asp Leu Asp Ala Asp Arg Gly Lys Leu Pro 
            20                  25                  30          


Gly Lys Lys Leu Pro Leu Glu Val Leu Lys Glu Met Glu Ala Asn Ala 
        35                  40                  45              


Arg Lys Ala Gly Cys Thr Arg Gly Cys Leu Ile Cys Leu Ser His Ile 
    50                  55                  60                  


Lys Cys Thr Pro Lys Met Lys Lys Phe Ile Pro Gly Arg Cys His Thr 
65                  70                  75                  80  


Tyr Glu Gly Asp Lys Glu Ser Ala Gln Gly Gly Ile Gly 
                85                  90              


<210> 6
<211> 76
<212> PRT
<213> Gaussia princeps

<400> 6
Glu Ala Ile Val Asp Ile Pro Glu Ile Pro Gly Phe Lys Asp Leu Glu 
1               5                   10                  15      


Pro Met Glu Gln Phe Ile Ala Gln Val Asp Leu Cys Val Asp Cys Thr 
            20                  25                  30          


Thr Gly Cys Leu Lys Gly Leu Ala Asn Val Gln Cys Ser Asp Leu Leu 
        35                  40                  45              


Lys Lys Trp Leu Pro Gln Arg Cys Ala Thr Phe Ala Ser Lys Ile Gln 
    50                  55                  60                  


Gly Gln Val Asp Lys Ile Lys Gly Ala Gly Gly Asp 
65                  70                  75      


<210> 7
<211> 157
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      sfGFP sequence

<400> 7
Met Arg Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
145                 150                 155         


<210> 8
<211> 81
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      sfGFP sequence

<400> 8
Lys Asn Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp 
1               5                   10                  15      


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
            20                  25                  30          


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser 
        35                  40                  45              


Val Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
    50                  55                  60                  


Glu Phe Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr 
65                  70                  75                  80  


Lys 
    


<210> 9
<211> 229
<212> PRT
<213> Renilla reniformis

<400> 9
Met Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly 
225                 


<210> 10
<211> 82
<212> PRT
<213> Renilla reniformis

<400> 10
Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr Asn Ala Tyr Leu Arg 
1               5                   10                  15      


Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu Ser Asp Pro Gly Phe 
            20                  25                  30          


Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys Phe Pro Asn Thr Glu 
        35                  40                  45              


Phe Val Lys Val Lys Gly Leu His Phe Ser Gln Glu Asp Ala Pro Asp 
    50                  55                  60                  


Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu Arg Val Leu Lys Asn 
65                  70                  75                  80  


Glu Gln 
        


<210> 11
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Cys Ser Gly Gly Ala Ser Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys 
1               5                   10                  15      


Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn 
            20                  25                  30          


Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Gly Ala Pro 
        35                  40                  45          


<210> 12
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Ser Gly Ala Ser Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys 
1               5                   10                  15      


Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu 
            20                  25                  30          


Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Gly Ala Pro Ser Gly Gly 
        35                  40                  45              


Cys 
    


<210> 13
<211> 47
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Cys Ser Gly Gly Ala Ser Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys 
1               5                   10                  15      


Val Lys Ser Phe Lys Ala Gln Asn Ser Glu Asn Ala Ser Thr Ala Asn 
            20                  25                  30          


Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Gly Ala Pro 
        35                  40                  45          


<210> 14
<211> 49
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Ser Gly Ala Ser Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys 
1               5                   10                  15      


Ser Phe Lys Ala Gln Asn Ser Glu Asn Ala Ser Thr Ala Asn Met Leu 
            20                  25                  30          


Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Gly Ala Pro Ser Gly Gly 
        35                  40                  45              


Cys 
    


<210> 15
<211> 46
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Cys Ser Gly Ala Ser Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val 
1               5                   10                  15      


Lys Ser Phe Lys Ala Gln Asn Ser Glu Asn Ala Ser Thr Ala Asn Met 
            20                  25                  30          


Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Lys Gly Ala Pro 
        35                  40                  45      


<210> 16
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Gly Ala Ser Leu Glu Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr 
1               5                   10                  15      


Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg 
            20                  25                  30          


Glu Gln Val Ala Gln Leu Lys Gln Lys Gly Ala Pro Ser Gly Gly Cys 
        35                  40                  45              


<210> 17
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ala Ser Arg Glu Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu 
1               5                   10                  15      


Glu Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys 
            20                  25                  30          


Glu Lys Glu Lys Leu Glu Gly Ala Pro 
        35                  40      


<210> 18
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ala Ser Arg Glu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu 
1               5                   10                  15      


Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu 
            20                  25                  30          


Lys Glu Lys Leu Glu Gly Ala Pro 
        35                  40  


<210> 19
<211> 43
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Ser Gly Ala Ser Arg Glu Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp 
1               5                   10                  15      


Gln Leu Glu Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu 
            20                  25                  30          


Leu Lys Glu Lys Glu Lys Leu Glu Gly Ala Pro 
        35                  40              


<210> 20
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ala Leu Lys Lys Glu Leu Gln Ala Asn Lys Lys Glu Leu Ala Gln Leu 
1               5                   10                  15      


Lys Trp Glu Leu Gln Ala Leu Lys Lys Glu Leu Ala Gln 
            20                  25                  


<210> 21
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Glu Gln Leu Glu Lys Lys Leu Gln Ala Leu Glu Lys Lys Leu Ala Gln 
1               5                   10                  15      


Leu Glu Trp Lys Asn Gln Ala Leu Glu Lys Lys Leu Ala Gln 
            20                  25                  30  


<210> 22
<211> 157
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown:
      sfGFP sequence

<400> 22
Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu 
    50                  55                  60                  


Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Arg 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln 
145                 150                 155         


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Ala Gly Ser Ser Ala Ala Gly Ser Gly Ser 
1               5                   10  


<210> 24
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly 
        


<210> 25
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly 
            20          


<210> 26
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
            20                  25      


<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210> 28
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly 
            20  


<210> 29
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25  


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Ser Gly Gly Gly Ser 
1               5   


<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ser Gly Ser Gly 
1               


<210> 32
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Ser Gly Gly Gly Gly Ser 
1               5       


<210> 33
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Ser Gly Ser Gly Gly 
1               5   


<210> 34
<211> 158
<212> PRT
<213> Oplophorus gracilirostris

<400> 34
Met Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu 
            20                  25                  30          


Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser 
        35                  40                  45              


Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser 
145                 150                 155             


<210> 35
<211> 11
<212> PRT
<213> Oplophorus gracilirostris

<400> 35
Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
1               5                   10      


<210> 36
<211> 11
<212> PRT
<213> Oplophorus gracilirostris

<400> 36
Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu 
1               5                   10      


<210> 37
<211> 302
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu 
            20                  25                  30          


Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser 
        35                  40                  45              


Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
145                 150                 155                 160 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
            180                 185                 190         


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Val Val 
        195                 200                 205             


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp Ser Ser 
    210                 215                 220                 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
225                 230                 235                 240 


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
                245                 250                 255     


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
            260                 265                 270         


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
        275                 280                 285             


Leu Lys Leu Glu Gly Gly Ser Gly His His His His His His 
    290                 295                 300         


<210> 38
<211> 289
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu 
            20                  25                  30          


Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser 
        35                  40                  45              


Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Val Gln Val 
                165                 170                 175     


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
            180                 185                 190         


Thr Val Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val 
        195                 200                 205             


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
    210                 215                 220                 


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
225                 230                 235                 240 


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
                245                 250                 255     


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
            260                 265                 270         


Val Glu Leu Leu Lys Leu Glu Gly Gly Ser Gly His His His His His 
        275                 280                 285             


His 
    


<210> 39
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met His His His His His His Gly Gly Ser Gly Gly Val Gln Val Glu 
1               5                   10                  15      


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            20                  25                  30          


Val Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
        35                  40                  45              


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    50                  55                  60                  


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
65                  70                  75                  80  


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                85                  90                  95      


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            100                 105                 110         


Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Val Ser Gly Trp Arg Leu Phe Lys Lys Ile Ser 
    130                 135                 140                 


<210> 40
<211> 144
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met His His His His His His Gly Gly Ser Gly Gly Val Gln Val Glu 
1               5                   10                  15      


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
            20                  25                  30          


Val Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Val Asp 
        35                  40                  45              


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
    50                  55                  60                  


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
65                  70                  75                  80  


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
                85                  90                  95      


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
            100                 105                 110         


Glu Leu Leu Lys Leu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu 
    130                 135                 140                 


