                         SEQUENCE LISTING

<110>  A2 Biotherapeutics, Inc.
       MOCK, Jee Young
 
<120>  T-Cell Receptor Having Substitutions in Transmembrane Domain

<130>  A2BI-034/01WO

<140>  PCT/US2021/058430
<141>  2021-11-08

<150>  US 63/111,503
<151>  2020-11-09

<160>  240   

<170>  PatentIn version 3.5

<210>  1
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys Gly Gly Ser 
        35                  40                  45              


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    50                  55                  60                  


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
65                  70                  75                  80  


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  


<210>  2
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile Gly Gly Ser Arg Ser Lys Arg Ser Arg 
    50                  55                  60                  


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
65                  70                  75                  80  


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                85                  90                  95      


Tyr Arg Ser 
            


<210>  3
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn Gly Gly Ser 
        35                  40                  45              


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    50                  55                  60                  


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
65                  70                  75                  80  


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  


<210>  4
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Met Val Lys Arg Lys Asp Ser Arg 
1               5                   10  


<210>  5
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  5

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  6
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Gly Val 
1               5                   10                  15      


Phe Cys Phe Ala 
            20  


<210>  7
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Met Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  8
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  9
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  10
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  11
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  12
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  12

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  13
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  13

Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln 
1               5                   10                  15      


Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg 
            20                  25                  30          


Phe Gln Lys Thr Cys Ser Pro Ile 
        35                  40  


<210>  14
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  14

Leu Tyr Cys Asn His Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg 
1               5                   10                  15      


Pro Val Val Lys Ser Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
            20                  25                  30          


<210>  15
<211>  537
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Cys Val Gln Cys Lys Asp Lys Glu Ala Thr Lys Leu Thr Glu 
1               5                   10                  15      


Glu Arg Asp Gly Ser Leu Asn Gln Ser Ser Gly Tyr Arg Tyr Gly Thr 
            20                  25                  30          


Asp Pro Thr Pro Gln His Tyr Pro Ser Phe Gly Val Thr Ser Ile Pro 
        35                  40                  45              


Asn Tyr Asn Asn Phe His Ala Ala Gly Gly Gln Gly Leu Thr Val Phe 
    50                  55                  60                  


Gly Gly Val Asn Ser Ser Ser His Thr Gly Thr Leu Arg Thr Arg Gly 
65                  70                  75                  80  


Gly Thr Gly Val Thr Leu Phe Val Ala Leu Tyr Asp Tyr Glu Ala Arg 
                85                  90                  95      


Thr Glu Asp Asp Leu Ser Phe His Lys Gly Glu Lys Phe Gln Ile Leu 
            100                 105                 110         


Asn Ser Ser Glu Gly Asp Trp Trp Glu Ala Arg Ser Leu Thr Thr Gly 
        115                 120                 125             


Glu Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Val Asp Ser Ile 
    130                 135                 140                 


Gln Ala Glu Glu Trp Tyr Phe Gly Lys Leu Gly Arg Lys Asp Ala Glu 
145                 150                 155                 160 


Arg Gln Leu Leu Ser Phe Gly Asn Pro Arg Gly Thr Phe Leu Ile Arg 
                165                 170                 175     


Glu Ser Glu Thr Thr Lys Gly Ala Tyr Ser Leu Ser Ile Arg Asp Trp 
            180                 185                 190         


Asp Asp Met Lys Gly Asp His Val Lys His Tyr Lys Ile Arg Lys Leu 
        195                 200                 205             


Asp Asn Gly Gly Tyr Tyr Ile Thr Thr Arg Ala Gln Phe Glu Thr Leu 
    210                 215                 220                 


Gln Gln Leu Val Gln His Tyr Ser Glu Arg Ala Ala Gly Leu Cys Cys 
225                 230                 235                 240 


Arg Leu Val Val Pro Cys His Lys Gly Met Pro Arg Leu Thr Asp Leu 
                245                 250                 255     


Ser Val Lys Thr Lys Asp Val Trp Glu Ile Pro Arg Glu Ser Leu Gln 
            260                 265                 270         


Leu Ile Lys Arg Leu Gly Asn Gly Gln Phe Gly Glu Val Trp Met Gly 
        275                 280                 285             


Thr Trp Asn Gly Asn Thr Lys Val Ala Ile Lys Thr Leu Lys Pro Gly 
    290                 295                 300                 


Thr Met Ser Pro Glu Ser Phe Leu Glu Glu Ala Gln Ile Met Lys Lys 
305                 310                 315                 320 


Leu Lys His Asp Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu 
                325                 330                 335     


Pro Ile Tyr Ile Val Thr Glu Tyr Met Asn Lys Gly Ser Leu Leu Asp 
            340                 345                 350         


Phe Leu Lys Asp Gly Glu Gly Arg Ala Leu Lys Leu Pro Asn Leu Val 
        355                 360                 365             


Asp Met Ala Ala Gln Val Ala Ala Gly Met Ala Tyr Ile Glu Arg Met 
    370                 375                 380                 


Asn Tyr Ile His Arg Asp Leu Arg Ser Ala Asn Ile Leu Val Gly Asn 
385                 390                 395                 400 


Gly Leu Ile Cys Lys Ile Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu 
                405                 410                 415     


Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp 
            420                 425                 430         


Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp 
        435                 440                 445             


Val Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Val Thr Lys Gly Arg 
    450                 455                 460                 


Val Pro Tyr Pro Gly Met Asn Asn Arg Glu Val Leu Glu Gln Val Glu 
465                 470                 475                 480 


Arg Gly Tyr Arg Met Pro Cys Pro Gln Asp Cys Pro Ile Ser Leu His 
                485                 490                 495     


Glu Leu Met Ile His Cys Trp Lys Lys Asp Pro Glu Glu Arg Pro Thr 
            500                 505                 510         


Phe Glu Tyr Leu Gln Ser Phe Leu Glu Asp Tyr Phe Thr Ala Thr Glu 
        515                 520                 525             


Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535         


<210>  16
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210>  17
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Asp Pro Ala Ala His Leu Pro Phe Phe Tyr Gly Ser Ile Ser 
1               5                   10                  15      


Arg Ala Glu Ala Glu Glu His Leu Lys Leu Ala Gly Met Ala Asp Gly 
            20                  25                  30          


Leu Phe Leu Leu Arg Gln Cys Leu Arg Ser Leu Gly Gly Tyr Val Leu 
        35                  40                  45              


Ser Leu Val His Asp Val Arg Phe His His Phe Pro Ile Glu Arg Gln 
    50                  55                  60                  


Leu Asn Gly Thr Tyr Ala Ile Ala Gly Gly Lys Ala His Cys Gly Pro 
65                  70                  75                  80  


Ala Glu Leu Cys Glu Phe Tyr Ser Arg Asp Pro Asp Gly Leu Pro Cys 
                85                  90                  95      


Asn Leu Arg Lys Pro Cys Asn Arg Pro Ser Gly Leu Glu Pro Gln Pro 
            100                 105                 110         


Gly Val Phe Asp Cys Leu Arg Asp Ala Met Val Arg Asp Tyr Val Arg 
        115                 120                 125             


Gln Thr Trp Lys Leu Glu Gly Glu Ala Leu Glu Gln Ala Ile Ile Ser 
    130                 135                 140                 


Gln Ala Pro Gln Val Glu Lys Leu Ile Ala Thr Thr Ala His Glu Arg 
145                 150                 155                 160 


Met Pro Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys 
                165                 170                 175     


Leu Tyr Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg 
            180                 185                 190         


Lys Glu Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val 
        195                 200                 205             


Tyr His Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro 
    210                 215                 220                 


Glu Gly Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys 
225                 230                 235                 240 


Leu Lys Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys Pro Asn 
                245                 250                 255     


Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu Pro Ala 
            260                 265                 270         


His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr Leu Asn 
        275                 280                 285             


Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro Asp Lys 
    290                 295                 300                 


Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro Tyr Ser 
305                 310                 315                 320 


Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg Asp Asn 
                325                 330                 335     


Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val 
            340                 345                 350         


Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile 
        355                 360                 365             


Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met 
    370                 375                 380                 


Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg 
385                 390                 395                 400 


Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met 
                405                 410                 415     


Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu 
            420                 425                 430         


Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly 
        435                 440                 445             


Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala 
    450                 455                 460                 


Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe 
465                 470                 475                 480 


Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg 
                485                 490                 495     


Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn 
            500                 505                 510         


Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr 
        515                 520                 525             


Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys 
    530                 535                 540                 


Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys 
545                 550                 555                 560 


Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp 
                565                 570                 575     


Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg 
            580                 585                 590         


Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly Pro Pro 
        595                 600                 605             


Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
    610                 615                 


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  18

Gly Gly Gly Gly Ser 
1               5   


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  19

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  20

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  21

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  22
<211>  135
<212>  DNA
<213>  Homo sapiens

<400>  22
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  23
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  23

Cys Thr Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  24
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  24
tgtaccattg aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc       60

attatccatg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      120

ccc                                                                    123


<210>  25
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Glu Ala Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu 
1               5                   10                  15      


Pro Ile Leu Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu 
            20                  25                  30          


Pro Gly Ser Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly 
        35                  40                  45              


Ile Gln Phe Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr 
    50                  55                  60                  


Pro Pro Val Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro 
65                  70                  75                  80  


Ile Pro Arg Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser 
                85                  90                  95      


Ser Arg Arg Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn 
            100                 105                 110         


Glu Glu Pro Ala Cys Glu Asp Ala Asp Glu Asp Glu Asp Asp Tyr His 
        115                 120                 125             


Asn Pro Gly Tyr Leu Val Val Leu Pro Asp Ser Thr Pro Ala Thr Ser 
    130                 135                 140                 


Thr Ala Ala Pro Ser Ala Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp 
145                 150                 155                 160 


Ser Ala Phe Ser Met Glu Ser Ile Asp Asp Tyr Val Asn Val Pro Glu 
                165                 170                 175     


Ser Gly Glu Ser Ala Glu Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val 
            180                 185                 190         


Asn Val Ser Gln Glu Leu His Pro Gly Ala Ala Lys Thr Glu Pro Ala 
        195                 200                 205             


Ala Leu Ser Ser Gln Glu Ala Glu Glu Val Glu Glu Glu Gly Ala Pro 
    210                 215                 220                 


Asp Tyr Glu Asn Leu Gln Glu Leu Asn 
225                 230             


<210>  26
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Leu Arg Asn Val Pro Phe Arg Ser Glu Val Leu Gly Trp Asp 
1               5                   10                  15      


Pro Asp Ser Leu Ala Asp Tyr Phe Lys Lys Leu Asn Tyr Lys Asp Cys 
            20                  25                  30          


Glu Lys Ala Val Lys Lys Tyr His Ile Asp Gly Ala Arg Phe Leu Asn 
        35                  40                  45              


Leu Thr Glu Asn Asp Ile Gln Lys Phe Pro Lys Leu Arg Val Pro Ile 
    50                  55                  60                  


Leu Ser Lys Leu Ser Gln Glu Ile Asn Lys Asn Glu Glu Arg Arg Ser 
65                  70                  75                  80  


Ile Phe Thr Arg Lys Pro Gln Val Pro Arg Phe Pro Glu Glu Thr Glu 
                85                  90                  95      


Ser His Glu Glu Asp Asn Gly Gly Trp Ser Ser Phe Glu Glu Asp Asp 
            100                 105                 110         


Tyr Glu Ser Pro Asn Asp Asp Gln Asp Gly Glu Asp Asp Gly Asp Tyr 
        115                 120                 125             


Glu Ser Pro Asn Glu Glu Glu Glu Ala Pro Val Glu Asp Asp Ala Asp 
    130                 135                 140                 


Tyr Glu Pro Pro Pro Ser Asn Asp Glu Glu Ala Leu Gln Asn Ser Ile 
145                 150                 155                 160 


Leu Pro Ala Lys Pro Phe Pro Asn Ser Asn Ser Met Tyr Ile Asp Arg 
                165                 170                 175     


Pro Pro Ser Gly Lys Thr Pro Gln Gln Pro Pro Val Pro Pro Gln Arg 
            180                 185                 190         


Pro Met Ala Ala Leu Pro Pro Pro Pro Ala Gly Arg Asn His Ser Pro 
        195                 200                 205             


Leu Pro Pro Pro Gln Thr Asn His Glu Glu Pro Ser Arg Ser Arg Asn 
    210                 215                 220                 


His Lys Thr Ala Lys Leu Pro Ala Pro Ser Ile Asp Arg Ser Thr Lys 
225                 230                 235                 240 


Pro Pro Leu Asp Arg Ser Leu Ala Pro Phe Asp Arg Glu Pro Phe Thr 
                245                 250                 255     


Leu Gly Lys Lys Pro Pro Phe Ser Asp Lys Pro Ser Ile Pro Ala Gly 
            260                 265                 270         


Arg Ser Leu Gly Glu His Leu Pro Lys Ile Gln Lys Pro Pro Leu Pro 
        275                 280                 285             


Pro Thr Thr Glu Arg His Glu Arg Ser Ser Pro Leu Pro Gly Lys Lys 
    290                 295                 300                 


Pro Pro Val Pro Lys His Gly Trp Gly Pro Asp Arg Arg Glu Asn Asp 
305                 310                 315                 320 


Glu Asp Asp Val His Gln Arg Pro Leu Pro Gln Pro Ala Leu Leu Pro 
                325                 330                 335     


Met Ser Ser Asn Thr Phe Pro Ser Arg Ser Thr Lys Pro Ser Pro Met 
            340                 345                 350         


Asn Pro Leu Pro Ser Ser His Met Pro Gly Ala Phe Ser Glu Ser Asn 
        355                 360                 365             


Ser Ser Phe Pro Gln Ser Ala Ser Leu Pro Pro Tyr Phe Ser Gln Gly 
    370                 375                 380                 


Pro Ser Asn Arg Pro Pro Ile Arg Ala Glu Gly Arg Asn Phe Pro Leu 
385                 390                 395                 400 


Pro Leu Pro Asn Lys Pro Arg Pro Pro Ser Pro Ala Glu Glu Glu Asn 
                405                 410                 415     


Ser Leu Asn Glu Glu Trp Tyr Val Ser Tyr Ile Thr Arg Pro Glu Ala 
            420                 425                 430         


Glu Ala Ala Leu Arg Lys Ile Asn Gln Asp Gly Thr Phe Leu Val Arg 
        435                 440                 445             


Asp Ser Ser Lys Lys Thr Thr Thr Asn Pro Tyr Val Leu Met Val Leu 
    450                 455                 460                 


Tyr Lys Asp Lys Val Tyr Asn Ile Gln Ile Arg Tyr Gln Lys Glu Ser 
465                 470                 475                 480 


Gln Val Tyr Leu Leu Gly Thr Gly Leu Arg Gly Lys Glu Asp Phe Leu 
                485                 490                 495     


Ser Val Ser Asp Ile Ile Asp Tyr Phe Arg Lys Met Pro Leu Leu Leu 
            500                 505                 510         


Ile Asp Gly Lys Asn Arg Gly Ser Arg Tyr Gln Cys Thr Leu Thr His 
        515                 520                 525             


Ala Ala Gly Tyr Pro 
    530             


<210>  27
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  27

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  28
<211>  136
<212>  PRT
<213>  Mus musculus

<400>  28

Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro Arg Ser 
1               5                   10                  15      


Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln Ile Asn 
            20                  25                  30          


Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile Ala Trp 
    50                  55                  60                  


Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu Thr Asn 
65                  70                  75                  80  


Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu Thr Glu 
                85                  90                  95      


Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu Ser Val 
            100                 105                 110         


Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
        115                 120                 125             


Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135     


<210>  29
<211>  140
<212>  PRT
<213>  Macaca fascicularis

<400>  29

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Lys Gly Ser Lys Ser 
1               5                   10                  15      


Asn Asp Thr Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Val Met Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val His Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Gly Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Thr Ser Ala Phe Lys Asp Ser Val 
65                  70                  75                  80  


Ile Pro Ala Asp Thr Phe Phe Pro Gly Thr Glu Ser Val Cys Asp Ala 
                85                  90                  95      


Asn Leu Val Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  30
<211>  135
<212>  PRT
<213>  Cavia porcellus

<400>  30

Ile Glu Asn Pro Glu Pro Ala Val Tyr Gln Leu Arg Asp Pro Lys Ser 
1               5                   10                  15      


Arg Asn Thr Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Asn Val Asn 
            20                  25                  30          


Leu Ser Glu Ser Val Leu Pro Gly Val Pro His Thr Gln Pro Thr Val 
        35                  40                  45              


Leu Asn Met Lys Ser Leu Asp Ser Lys Ser Asn Ala Ala Val Ala Trp 
    50                  55                  60                  


Ser Ser Lys Ser Asn Phe Asp Cys Arg Asn Thr Phe Gly Asp Pro Thr 
65                  70                  75                  80  


Phe Tyr Pro Ser Ser Asp Tyr Pro Cys Asn Ala Thr Leu Val Glu Glu 
                85                  90                  95      


Ser Phe Glu Thr Asp Met Asn Leu Asn Leu Glu Asn Leu Ser Val Met 
            100                 105                 110         


Ala Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met 
        115                 120                 125             


Thr Leu Arg Leu Trp Ser Ser 
    130                 135 


<210>  31
<211>  134
<212>  PRT
<213>  Felix catus

<400>  31

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Lys Ser Pro Glu Ser 
1               5                   10                  15      


Ser Asn Ile Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Glu Val Asn 
            20                  25                  30          


Val Asn Pro Ser Thr Glu Ser Asn Met Ile Arg Leu Lys Ser Thr Ser 
        35                  40                  45              


Leu Asp Met Lys Thr Met Asp Ser Lys Ser Asn Gly Ala Leu Ala Trp 
    50                  55                  60                  


Gly Asn Ser Phe Asp Leu Gly Cys Asn Ser Thr Phe Asn Tyr Thr Phe 
65                  70                  75                  80  


His Ser Ser Ser Glu Phe Pro Cys Asp Ala Asn Val Val Glu Lys Gly 
                85                  90                  95      


Phe Glu Thr Asp Met Asn Leu Asn Phe Asp Asn Leu Thr Val Ile Met 
            100                 105                 110         


Leu Arg Ile Ile Phe Leu Lys Ala Val Gly Phe Asn Leu Leu Met Thr 
        115                 120                 125             


Leu Lys Leu Trp Ser Ser 
    130                 


<210>  32
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175     


<210>  33
<211>  173
<212>  PRT
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Xaa Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
65                  70                  75                  80  


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
                85                  90                  95      


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
            100                 105                 110         


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
        115                 120                 125             


Ile Thr Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
    130                 135                 140                 


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
145                 150                 155                 160 


Thr Leu Val Val Met Ala Met Val Lys Arg Lys Asn Ser 
                165                 170             


<210>  34
<211>  174
<212>  PRT
<213>  Rattus norvegicus

<400>  34

Glu Asp Leu Lys Thr Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ala Asp Lys Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Ile Arg Asn Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
    50                  55                  60                  


Glu Ser Asn Asn Ile Thr Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
65                  70                  75                  80  


Ala Pro Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
                85                  90                  95      


Phe Tyr Gly Leu Thr Glu Glu Asp Asn Trp Ser Glu Asp Ser Pro Lys 
            100                 105                 110         


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
        115                 120                 125             


Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile 
    130                 135                 140                 


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
145                 150                 155                 160 


Ser Ala Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
                165                 170                 


<210>  35
<211>  177
<212>  PRT
<213>  Sus scrofa

<400>  35

Glu Asp Leu Gln Gln Val Arg Pro Pro Lys Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Ala Glu Ile Ser Arg Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Gln Val Gln Ser Gly Val Ser Thr Asp Leu Gln Pro Tyr Arg 
    50                  55                  60                  


Glu Asp Pro Ser Arg Asn Asp Ser Ser Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Thr Ala Ala Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Thr Glu Asp Asp Glu Trp Glu Tyr Asn 
            100                 105                 110         


Trp Thr Lys Pro Ile Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Lys 
        115                 120                 125             


Ala Asp Cys Gly Phe Ser Ser Ala Ser Tyr Gln Gln Gly Val Leu Ser 
    130                 135                 140                 


Ala Thr Leu Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala 
145                 150                 155                 160 


Val Leu Val Ser Ala Leu Val Leu Met Ala Thr Val Lys Lys Lys Asp 
                165                 170                 175     


Ser 
    


<210>  36
<211>  177
<212>  PRT
<213>  Callithrix jacchus

<400>  36

Asp Asp Leu Ser Lys Val Phe Pro Pro Thr Val Ala Val Phe Glu Pro 
1               5                   10                  15      


Ser Glu Thr Glu Ile Ser Arg Thr Gln Lys Ala Thr Leu Val Cys Leu 
            20                  25                  30          


Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
        35                  40                  45              


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys 
    50                  55                  60                  


Glu Gln Pro Ala Leu Asn Asp Ser Lys Tyr Cys Leu Ser Ser Arg Leu 
65                  70                  75                  80  


Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys 
                85                  90                  95      


Gln Val Gln Phe Tyr Gly Leu Ser Glu Asp Asp Glu Trp Thr Gln Pro 
            100                 105                 110         


Arg Ala Lys Pro Ile Asp Gln Asn Val Ser Ala Glu Ala Trp Gly Arg 
        115                 120                 125             


Ala Gly Glu Arg Ala Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Val 
    130                 135                 140                 


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
145                 150                 155                 160 


Ser Ala Leu Val Leu Met Ala Met Val Arg Arg Arg Val Gly Ser Asp 
                165                 170                 175     


Arg 
    


<210>  37
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  38
<211>  173
<212>  PRT
<213>  Mus musculus

<400>  38

Met Glu His Ser Gly Ile Leu Ala Ser Leu Ile Leu Ile Ala Val Leu 
1               5                   10                  15      


Pro Gln Gly Ser Pro Phe Lys Ile Gln Val Thr Glu Tyr Glu Asp Lys 
            20                  25                  30          


Val Phe Val Thr Cys Asn Thr Ser Val Met His Leu Asp Gly Thr Val 
        35                  40                  45              


Glu Gly Trp Phe Ala Lys Asn Lys Thr Leu Asn Leu Gly Lys Gly Val 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Leu Cys Asn Gly Thr Glu Gln Leu Ala 
65                  70                  75                  80  


Lys Val Val Ser Ser Val Gln Val His Tyr Arg Met Cys Gln Asn Cys 
                85                  90                  95      


Val Glu Leu Asp Ser Gly Thr Met Ala Gly Val Ile Phe Ile Asp Leu 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Tyr Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Pro Ser Gly Ala Ala Glu Val Gln Ala Leu Leu Lys 
    130                 135                 140                 


Asn Glu Gln Leu Tyr Gln Pro Leu Arg Asp Arg Glu Asp Thr Gln Tyr 
145                 150                 155                 160 


Ser Arg Leu Gly Gly Asn Trp Pro Arg Asn Lys Lys Ser 
                165                 170             


<210>  39
<211>  171
<212>  PRT
<213>  Sus scrofa

<400>  39

Met Glu His Ser Arg Phe Leu Ser Gly Leu Ile Leu Ala Ala Phe Leu 
1               5                   10                  15      


Ser Arg Val Ser Pro Tyr Glu Val Glu Met Glu Glu Leu Glu Asp Lys 
            20                  25                  30          


Val Phe Val Ser Cys Asn Thr Ser Ile Ile Trp Leu Gln Gly Thr Glu 
        35                  40                  45              


Gly Glu Leu Leu Ser Asp Lys Lys Ile Asp Leu Gly Lys Arg Ile Leu 
    50                  55                  60                  


Asp Pro Arg Gly Leu Tyr Lys Cys Asn Ala Pro Lys Glu Gln Asp Ser 
65                  70                  75                  80  


Asn Ser Lys Ile Phe Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys 
                85                  90                  95      


Val Glu Leu Asp Ser Ala Thr Leu Ala Gly Ile Ile Val Thr Asp Ile 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Tyr Cys Phe Ala Gly His 
        115                 120                 125             


Glu Met Gly Arg Phe Ser Arg Ala Ala Asp Thr Gln Asp Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Leu Tyr Gln Pro Leu Arg Asp Arg Asn Asp Gly Gln Tyr 
145                 150                 155                 160 


Ser Arg Leu Gly Glu Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  40
<211>  173
<212>  PRT
<213>  Rattus norvegicus

<400>  40

Met Glu His Tyr Gly Ile Leu Val Ser Leu Leu Leu Ala Thr Val Leu 
1               5                   10                  15      


Pro Gln Gly Ser Pro Phe Lys Ile Glu Val Val Glu Tyr Glu Asp Lys 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Arg His Leu Asp Gly Ser Val 
        35                  40                  45              


Glu Arg Trp Leu Thr Lys Asn Lys Ser Leu Ile Leu Gly Lys Gly Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Met Tyr Met Cys Asn Gly Thr Glu Glu Leu Ala 
65                  70                  75                  80  


Lys Glu Val Ser Thr Val Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys 
                85                  90                  95      


Val Glu Leu Asp Ser Ala Thr Leu Ala Gly Val Ile Ile Thr Asp Leu 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Tyr Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Val Asp Thr Gln Val Leu Leu Lys 
    130                 135                 140                 


Asn Glu Gln Leu Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser Arg Leu Gly Gly Asn Trp Pro Arg Asn Lys Arg Ser 
                165                 170             


<210>  41
<211>  171
<212>  PRT
<213>  Macaca fascicularis

<400>  41

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Val Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Lys Cys Asn Thr Ser Val Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Thr Asn Asn Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Ala Val Gln Val His Tyr Arg Met Cys Gln Asn Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Leu Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser Arg Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  42
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  43
<211>  189
<212>  PRT
<213>  Mus musculus

<400>  43

Met Arg Trp Asn Thr Phe Trp Gly Ile Leu Cys Leu Ser Leu Leu Ala 
1               5                   10                  15      


Val Gly Thr Cys Gln Asp Asp Ala Glu Asn Ile Glu Tyr Lys Val Ser 
            20                  25                  30          


Ile Ser Gly Thr Ser Val Glu Leu Thr Cys Pro Leu Asp Ser Asp Glu 
        35                  40                  45              


Asn Leu Lys Trp Glu Lys Asn Gly Gln Glu Leu Pro Gln Lys His Asp 
    50                  55                  60                  


Lys His Leu Val Leu Gln Asp Phe Ser Glu Val Glu Asp Ser Gly Tyr 
65                  70                  75                  80  


Tyr Val Cys Tyr Thr Pro Ala Ser Asn Lys Asn Thr Tyr Leu Tyr Leu 
                85                  90                  95      


Lys Ala Arg Val Cys Glu Tyr Cys Val Glu Val Asp Leu Thr Ala Val 
            100                 105                 110         


Ala Ile Ile Ile Ile Val Asp Ile Cys Ile Thr Leu Gly Leu Leu Met 
        115                 120                 125             


Val Ile Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys Pro Val 
    130                 135                 140                 


Thr Arg Gly Thr Gly Ala Gly Ser Arg Pro Arg Gly Gln Asn Lys Glu 
145                 150                 155                 160 


Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly 
                165                 170                 175     


Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Ala Val 
            180                 185                 


<210>  44
<211>  196
<212>  PRT
<213>  Sus scrofa

<400>  44

Met Pro Ser Gly Asn Leu Trp Lys Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Ala Trp Gly Gln Glu Asp Ile Glu Arg Pro Asp Glu Asp Thr 
            20                  25                  30          


Gln Lys Thr Phe Lys Val Ser Ile Ser Gly Asp Lys Val Glu Leu Thr 
        35                  40                  45              


Cys Pro Glu Asp Pro Glu Ser Glu Lys Met Thr Trp Lys Arg Asn Asp 
    50                  55                  60                  


Met Gln Ile Tyr Glu Ser Tyr Asp Asn Tyr Met Leu Leu Glu Ser Phe 
65                  70                  75                  80  


Ser Glu Val Glu Asn Ser Gly Tyr Tyr Thr Cys Thr Val Gly Glu Lys 
                85                  90                  95      


Thr Ser His Arg Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn Cys Val 
            100                 105                 110         


Glu Val Asp Leu Met Ala Val Val Thr Ile Ile Val Val Asp Ile Cys 
        115                 120                 125             


Ile Thr Leu Gly Leu Leu Met Val Val Tyr Tyr Tyr Ser Lys Ser Arg 
    130                 135                 140                 


Lys Ala Lys Ala Met Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg 
145                 150                 155                 160 


Pro Arg Gly Gln Asn Arg Glu Arg Pro Pro Pro Val Pro Asn Pro Asp 
                165                 170                 175     


Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn 
            180                 185                 190         


Gln Arg Gly Arg 
        195     


<210>  45
<211>  198
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  45

Met Arg Ala Gly Thr Leu Trp Arg Val Leu Ala Leu Trp Leu Leu Ser 
1               5                   10                  15      


Val Ala Ala Trp Gly Gln Glu Asp Asp Asp His Ala Asp Asp Tyr Thr 
            20                  25                  30          


Gln Lys Leu Phe Thr Val Ser Ile Ser Gly Thr Arg Val Val Leu Thr 
        35                  40                  45              


Cys Pro Val Glu Ala Glu Gly Gly Asp Ile His Trp Glu Arg Asp Glu 
    50                  55                  60                  


Lys Ser Leu Pro Asn Thr Lys Lys Glu Leu Asp Leu Thr Asp Phe Ser 
65                  70                  75                  80  


Glu Met Glu His Ser Gly Tyr Tyr Ser Cys Tyr Val Gly Thr Lys Asn 
                85                  90                  95      


Lys Glu Asn Glu His Ile Leu Tyr Leu Lys Ala Arg Val Cys Glu Ala 
            100                 105                 110         


Cys Met Glu Val Asp Leu Thr Thr Val Ala Ser Ile Val Val Ala Asp 
        115                 120                 125             


Val Cys Val Thr Leu Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys 
    130                 135                 140                 


Asn Arg Lys Ala Lys Cys Lys Pro Val Thr Arg Gly Ala Gly Ala Gly 
145                 150                 155                 160 


Gly Arg Pro Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn 
                165                 170                 175     


Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser Gly 
            180                 185                 190         


Leu Asn Gln Arg Gly Ile 
        195             


<210>  46
<211>  198
<212>  PRT
<213>  Macaca fascicularis

<400>  46

Met Gln Ser Gly Thr Arg Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Ile Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Ser Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Gln Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Ser Gln His Leu Gly Ser Glu Ala Gln Trp Gln His Asn Gly Lys 
    50                  55                  60                  


Asn Lys Glu Asp Ser Gly Asp Arg Leu Phe Leu Pro Glu Phe Ser Glu 
65                  70                  75                  80  


Met Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly Ser Asn Pro 
                85                  90                  95      


Glu Asp Ala Ser His His Leu Tyr Leu Lys Ala Arg Val Cys Glu Asn 
            100                 105                 110         


Cys Met Glu Met Asp Val Met Ala Val Ala Thr Ile Val Ile Val Asp 
        115                 120                 125             


Ile Cys Ile Thr Leu Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser Lys 
    130                 135                 140                 


Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala Gly 
145                 150                 155                 160 


Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro Asn 
                165                 170                 175     


Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Gln Asp Leu Tyr Ser Gly 
            180                 185                 190         


Leu Asn Gln Arg Arg Ile 
        195             


<210>  47
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  48
<211>  182
<212>  PRT
<213>  Mus musculus

<400>  48

Met Glu Gln Arg Lys Gly Leu Ala Gly Leu Phe Leu Val Ile Ser Leu 
1               5                   10                  15      


Leu Gln Gly Thr Val Ala Gln Thr Asn Lys Ala Lys Asn Leu Val Gln 
            20                  25                  30          


Val Asp Gly Ser Arg Gly Asp Gly Ser Val Leu Leu Thr Cys Gly Leu 
        35                  40                  45              


Thr Asp Lys Thr Ile Lys Trp Leu Lys Asp Gly Ser Ile Ile Ser Pro 
    50                  55                  60                  


Leu Asn Ala Thr Lys Asn Thr Trp Asn Leu Gly Asn Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Thr Tyr Gln Cys Gln Gly Ala Lys Glu Thr Ser Asn Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Glu Asn Cys Ile Glu Leu Asn Ile 
            100                 105                 110         


Gly Thr Ile Ser Gly Phe Ile Phe Ala Glu Val Ile Ser Ile Phe Phe 
        115                 120                 125             


Leu Ala Leu Gly Val Tyr Leu Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Gln Asn Glu Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Tyr Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Lys Lys 
            180         


<210>  49
<211>  182
<212>  PRT
<213>  Sus scrofa

<400>  49

Met Glu Gln Gly Lys His Leu Ala Gly Leu Ile Leu Ala Ile Thr Leu 
1               5                   10                  15      


Leu Gln Gly Thr Met Ala Gln Leu Lys Glu Gly Lys His Ser Val Leu 
            20                  25                  30          


Leu Asp Asp Asn Arg Glu Asp Gly Ser Val Leu Leu Thr Cys Gly Leu 
        35                  40                  45              


Pro Asp Gln Asn Ile Arg Trp Phe Lys Asp Gly Lys Glu Ile Cys Ser 
    50                  55                  60                  


Leu Asn Asn Ser Arg Ser Thr Cys Asn Leu Gly Ser Ser Ser Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Ile Tyr Trp Cys Glu Gly Ser Lys Glu Asn Ser Lys Arg 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ser 
            100                 105                 110         


Ala Thr Val Ser Gly Phe Ile Phe Thr Glu Ile Ile Ser Leu Phe Phe 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Ser Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Asn Ser Arg Lys Asn 
            180         


<210>  50
<211>  182
<212>  PRT
<213>  Rattus norvegicus

<400>  50

Met Glu Gln Gly Lys Gly Leu Ala Gly Leu Phe Leu Val Ile Ser Leu 
1               5                   10                  15      


Leu Gln Gly Thr Met Ala Gln Gln Lys Glu Glu Lys His Leu Val Lys 
            20                  25                  30          


Val Asp Asp Ser Gln Gly Asp Gly Ser Val Leu Leu Thr Cys Asp Phe 
        35                  40                  45              


Asn Glu Lys Thr Ile Thr Trp Leu Lys Asp Gly His Arg Ile Ser Pro 
    50                  55                  60                  


Pro Asn Ala Thr Lys Ser Thr Trp Asn Leu Gly Asn Gly Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Arg Gly Ala Lys Lys Lys Ser Gln Leu 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Leu Cys Glu Asn Cys Ile Glu Leu Asn Met 
            100                 105                 110         


Gly Thr Val Ser Gly Phe Ile Phe Ala Glu Ile Ile Ser Ile Phe Phe 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Gln Asn Glu Gln Val Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Tyr Glu Gln Tyr Ser Arg Leu Gln Gly 
                165                 170                 175     


Asn Gln Val Arg Lys Lys 
            180         


<210>  51
<211>  181
<212>  PRT
<213>  Macaca fascicularis

<400>  51

Met Val Gln Gly Lys Gly Leu Thr Gly Phe Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Ser Leu Ala Gln Ser Phe Glu Glu Asn Arg Lys Leu Asn 
            20                  25                  30          


Val Tyr Asn Gln Glu Asp Gly Ser Val Leu Leu Thr Cys His Val Lys 
        35                  40                  45              


Asn Thr Asn Ile Thr Trp Phe Lys Glu Gly Lys Met Ile Asp Ile Leu 
    50                  55                  60                  


Thr Ala His Lys Asn Lys Trp Asn Leu Gly Ser Asn Thr Lys Asp Pro 
65                  70                  75                  80  


Arg Gly Val Tyr Gln Cys Lys Gly Ser Lys Asp Lys Ser Lys Thr Leu 
                85                  90                  95      


Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala 
            100                 105                 110         


Thr Ile Leu Gly Phe Val Phe Ala Glu Ile Ile Ser Ile Phe Phe Leu 
        115                 120                 125             


Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln Ser 
    130                 135                 140                 


Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr Gln 
145                 150                 155                 160 


Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly Asn 
                165                 170                 175     


Gln Leu Arg Met Asn 
            180     


<210>  52
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ser Leu Thr Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Gln Gly Ala Trp Pro Leu Met Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Arg Pro Ser Thr Val Val Pro Arg Gly Gly His Val Ala Leu Gln 
        35                  40                  45              


Cys His Tyr Arg Arg Gly Phe Asn Asn Phe Met Leu Tyr Lys Glu Asp 
    50                  55                  60                  


Arg Ser His Val Pro Ile Phe His Gly Arg Ile Phe Gln Glu Ser Phe 
65                  70                  75                  80  


Ile Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Arg 
                85                  90                  95      


Gly Ser Arg Pro His Ser Leu Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Leu Val Ile Met Val Thr Gly Asn His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Leu Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Met Phe Glu His Phe Phe Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Ser Glu Asp Pro Ser Arg Leu Val Gly Gln Ile His Asp Gly Val Ser 
                165                 170                 175     


Lys Ala Asn Phe Ser Ile Gly Pro Leu Met Pro Val Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Tyr Gly Ser Val Pro His Ser Pro Tyr Gln Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Ile Thr Gly Leu Tyr Glu Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Trp Ser Ser Tyr Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Gly Glu Ala His Glu Arg Arg Leu Arg Ala Val Pro Lys Val 
            260                 265                 270         


Asn Arg Thr Phe Gln Ala Asp Phe Pro Leu Gly Pro Ala Thr His Gly 
        275                 280                 285             


Gly Thr Tyr Arg Cys Phe Gly Ser Phe His Ala Leu Pro Cys Val Trp 
    290                 295                 300                 


Ser Asn Ser Ser Asp Pro Leu Leu Val Ser Val Thr Gly Asn Pro Ser 
305                 310                 315                 320 


Ser Ser Trp Pro Ser Pro Thr Glu Pro Ser Ser Lys Ser Gly Ile Cys 
                325                 330                 335     


Arg His Leu His Val Leu Ile Gly Thr Ser Val Val Ile Phe Leu Phe 
            340                 345                 350         


Ile Leu Leu Leu Phe Phe Leu Leu Tyr Arg Trp Cys Ser Asn Lys Lys 
        355                 360                 365             


Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg Thr Val Asn 
    370                 375                 380                 


Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln 
385                 390                 395                 400 


Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg Pro Ser Gln 
                405                 410                 415     


Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr Glu Leu Pro 
            420                 425                 430         


Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg Ala Pro Gln 
        435                 440                 445             


Ser Gly Leu Glu Gly Val Phe 
    450                 455 


<210>  53
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Glu Gly Pro Trp Pro His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Trp Pro Ser Thr Val Val Ser Glu Gly Gln His Val Thr Leu Gln 
        35                  40                  45              


Cys Arg Ser Arg Leu Gly Phe Asn Glu Phe Ser Leu Ser Lys Glu Asp 
    50                  55                  60                  


Gly Met Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Arg Asn Ser Phe 
65                  70                  75                  80  


Leu Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Cys 
                85                  90                  95      


Ser Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Val His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Val Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Arg Phe Glu Arg Phe Leu Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Thr Glu Asp Pro Leu Arg Leu Val Gly Gln Leu His Asp Ala Gly Ser 
                165                 170                 175     


Gln Val Asn Tyr Ser Met Gly Pro Met Thr Pro Ala Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Val Thr His Leu Pro Tyr Glu Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Val Val Gly Leu Tyr Gly Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Arg Ser Leu Phe Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Ala Glu Ala Gly Glu Leu Arg Leu Thr Ala Val Leu Arg Val 
            260                 265                 270         


Asn Gly Thr Phe Gln Ala Asn Phe Pro Leu Gly Pro Val Thr His Gly 
        275                 280                 285             


Gly Asn Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro His Ala Trp 
    290                 295                 300                 


Ser Asp Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Ser Arg 
305                 310                 315                 320 


Tyr Leu His Ala Leu Ile Gly Thr Ser Val Val Ile Ile Pro Phe Ala 
                325                 330                 335     


Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ala Asn Lys Lys Asn 
            340                 345                 350         


Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val Asn Arg 
        355                 360                 365             


Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
    370                 375                 380                 


Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg 
385                 390                 395                 400 


Pro Lys Thr Pro Pro Thr Asp Thr Ser Val 
                405                 410 


<210>  54
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  54

Phe Phe Tyr Gly Ser Ile Ser Arg Ala Glu Ala Glu Glu His Leu Lys 
1               5                   10                  15      


Leu Ala Gly Met Ala Asp Gly Leu Phe Leu Leu Arg Gln Cys Leu Arg 
            20                  25                  30          


Ser Leu Gly Gly Tyr Val Leu Ser Leu Val His Asp Val Arg Phe His 
        35                  40                  45              


His Phe Pro Ile Glu Arg Gln Leu Asn Gly Thr Tyr Ala Ile Ala Gly 
    50                  55                  60                  


Gly Lys Ala His Cys Gly Pro Ala Glu Leu Cys Glu Phe Tyr Ser Arg 
65                  70                  75                  80  


Asp Pro Asp Gly Leu Pro Cys Asn Leu Arg Lys Pro Cys 
                85                  90              


<210>  55
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  55

Trp Tyr His Ser Ser Leu Thr Arg Glu Glu Ala Glu Arg Lys Leu Tyr 
1               5                   10                  15      


Ser Gly Ala Gln Thr Asp Gly Lys Phe Leu Leu Arg Pro Arg Lys Glu 
            20                  25                  30          


Gln Gly Thr Tyr Ala Leu Ser Leu Ile Tyr Gly Lys Thr Val Tyr His 
        35                  40                  45              


Tyr Leu Ile Ser Gln Asp Lys Ala Gly Lys Tyr Cys Ile Pro Glu Gly 
    50                  55                  60                  


Thr Lys Phe Asp Thr Leu Trp Gln Leu Val Glu Tyr Leu Lys Leu Lys 
65                  70                  75                  80  


Ala Asp Gly Leu Ile Tyr Cys Leu Lys Glu Ala Cys 
                85                  90          


<210>  56
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Thr Pro Ile Leu Thr Val Leu Ile Cys Leu Gly Leu Ser Leu Gly 
1               5                   10                  15      


Pro Arg Thr His Val Gln Ala Gly His Leu Pro Lys Pro Thr Leu Trp 
            20                  25                  30          


Ala Glu Pro Gly Ser Val Ile Thr Gln Gly Ser Pro Val Thr Leu Arg 
        35                  40                  45              


Cys Gln Gly Gly Gln Glu Thr Gln Glu Tyr Arg Leu Tyr Arg Glu Lys 
    50                  55                  60                  


Lys Thr Ala Leu Trp Ile Thr Arg Ile Pro Gln Glu Leu Val Lys Lys 
65                  70                  75                  80  


Gly Gln Phe Pro Ile Pro Ser Ile Thr Trp Glu His Ala Gly Arg Tyr 
                85                  90                  95      


Arg Cys Tyr Tyr Gly Ser Asp Thr Ala Gly Arg Ser Glu Ser Ser Asp 
            100                 105                 110         


Pro Leu Glu Leu Val Val Thr Gly Ala Tyr Ile Lys Pro Thr Leu Ser 
        115                 120                 125             


Ala Gln Pro Ser Pro Val Val Asn Ser Gly Gly Asn Val Ile Leu Gln 
    130                 135                 140                 


Cys Asp Ser Gln Val Ala Phe Asp Gly Phe Ser Leu Cys Lys Glu Gly 
145                 150                 155                 160 


Glu Asp Glu His Pro Gln Cys Leu Asn Ser Gln Pro His Ala Arg Gly 
                165                 170                 175     


Ser Ser Arg Ala Ile Phe Ser Val Gly Pro Val Ser Pro Ser Arg Arg 
            180                 185                 190         


Trp Trp Tyr Arg Cys Tyr Ala Tyr Asp Ser Asn Ser Pro Tyr Glu Trp 
        195                 200                 205             


Ser Leu Pro Ser Asp Leu Leu Glu Leu Leu Val Leu Gly Val Ser Lys 
    210                 215                 220                 


Lys Pro Ser Leu Ser Val Gln Pro Gly Pro Ile Val Ala Pro Glu Glu 
225                 230                 235                 240 


Thr Leu Thr Leu Gln Cys Gly Ser Asp Ala Gly Tyr Asn Arg Phe Val 
                245                 250                 255     


Leu Tyr Lys Asp Gly Glu Arg Asp Phe Leu Gln Leu Ala Gly Ala Gln 
            260                 265                 270         


Pro Gln Ala Gly Leu Ser Gln Ala Asn Phe Thr Leu Gly Pro Val Ser 
        275                 280                 285             


Arg Ser Tyr Gly Gly Gln Tyr Arg Cys Tyr Gly Ala His Asn Leu Ser 
    290                 295                 300                 


Ser Glu Trp Ser Ala Pro Ser Asp Pro Leu Asp Ile Leu Ile Ala Gly 
305                 310                 315                 320 


Gln Phe Tyr Asp Arg Val Ser Leu Ser Val Gln Pro Gly Pro Thr Val 
                325                 330                 335     


Ala Ser Gly Glu Asn Val Thr Leu Leu Cys Gln Ser Gln Gly Trp Met 
            340                 345                 350         


Gln Thr Phe Leu Leu Thr Lys Glu Gly Ala Ala Asp Asp Pro Trp Arg 
        355                 360                 365             


Leu Arg Ser Thr Tyr Gln Ser Gln Lys Tyr Gln Ala Glu Phe Pro Met 
    370                 375                 380                 


Gly Pro Val Thr Ser Ala His Ala Gly Thr Tyr Arg Cys Tyr Gly Ser 
385                 390                 395                 400 


Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp Pro Leu Glu 
                405                 410                 415     


Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly 
            420                 425                 430         


Pro Thr Ser Thr Ser Ala Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr 
        435                 440                 445             


Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val Val Ile 
    450                 455                 460                 


Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu 
465                 470                 475                 480 


Phe Leu Ile Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr 
                485                 490                 495     


Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu 
            500                 505                 510         


Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala 
        515                 520                 525             


Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp 
    530                 535                 540                 


Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala 
545                 550                 555                 560 


Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala 
                565                 570                 575     


Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg 
            580                 585                 590         


Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu 
        595                 600                 605             


Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg 
    610                 615                 620                 


Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala 
625                 630                 635                 640 


Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                645                 650     


<210>  57
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  58
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  59
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  60
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro 
                245                 250                 255     


Gly Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro 
            260                 265                 270         


Ala Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn 
        275                 280                 285             


Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro 
    290                 295                 300                 


Asp Asp Gln Asn Arg Ile 
305                 310 


<210>  61
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  61

Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
1               5                   10                  15      


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
            20                  25                  30          


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
        35                  40                  45              


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
    50                  55                  60                  


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
65                  70                  75                  80  


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
                85                  90                  95      


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
            100                 105                 110         


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
        115                 120                 125             


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
    130                 135                 140                 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
145                 150                 155                 160 


Ile Tyr Ala Thr Leu Ala Ile His 
                165             


<210>  62
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  62

Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
1               5                   10                  15      


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
            20                  25                  30          


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
        35                  40                  45              


Asn Leu Tyr Ala Ala Val Lys Asp Thr Gln Pro Glu Asp Gly Val Glu 
    50                  55                  60                  


Met Asp Thr Arg Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr 
65                  70                  75                  80  


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr Glu Pro Pro 
                85                  90                  95      


Pro Ser Gln Glu Arg Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Thr 
            100                 105                 110         


Leu Ala Ile His 
        115     


<210>  63
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  63

Arg Arg Gln Arg His Ser Lys His Arg Thr Ser Asp Gln Arg Lys Thr 
1               5                   10                  15      


Asp Phe Gln Arg Pro Ala Gly Ala Ala Glu Thr Glu Pro Lys Asp Arg 
            20                  25                  30          


Gly Leu Leu Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Glu Glu Asn 
        35                  40                  45              


Leu Tyr Ala Ala Val Lys Asp Thr Gln Ser Glu Asp Arg Val Glu Leu 
    50                  55                  60                  


Asp Ser Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
65                  70                  75                  80  


Pro Val Lys His Ser Ser Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
                85                  90                  95      


Ser Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Val Glu Glu 
            100                 105                 110         


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Ser Gln Asp 
        115                 120                 125             


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Lys Ala Thr 
    130                 135                 140                 


Glu Pro Pro Pro Ser Gln Glu Gly Glu Pro Pro Ala Glu Pro Ser Ile 
145                 150                 155                 160 


Tyr Ala Thr Leu Ala Ile His 
                165         


<210>  64
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  64

Gln His Trp Arg Gln Gly Lys His Arg Thr Leu Ala Gln Arg Gln Ala 
1               5                   10                  15      


Asp Phe Gln Arg Pro Pro Gly Ala Ala Glu Pro Glu Pro Lys Asp Gly 
            20                  25                  30          


Gly Leu Gln Arg Arg Ser Ser Pro Ala Ala Asp Val Gln Gly Glu Asn 
        35                  40                  45              


Phe Cys Ala Ala Val Lys Asn Thr Gln Pro Glu Asp Gly Val Glu Met 
    50                  55                  60                  


Asp Thr Arg Gln Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
65                  70                  75                  80  


Ala Lys Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
                85                  90                  95      


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
            100                 105                 110         


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
        115                 120                 125             


Asp Val Thr Tyr Ala Gln Leu His Ser Phe Thr Leu Arg Gln Lys Ala 
    130                 135                 140                 


Thr Glu Pro Pro Pro Ser Gln Glu Gly Ala Ser Pro Ala Glu Pro Ser 
145                 150                 155                 160 


Val Tyr Ala Thr Leu Ala Ile His 
                165             


<210>  65
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  65

Arg His Arg His Gln Ser Lys His Arg Thr Ser Ala His Phe Tyr Arg 
1               5                   10                  15      


Pro Ala Gly Ala Ala Gly Pro Glu Pro Lys Asp Gln Gly Leu Gln Lys 
            20                  25                  30          


Arg Ala Ser Pro Val Ala Asp Ile Gln Glu Glu Ile Leu Asn Ala Ala 
        35                  40                  45              


Val Lys Asp Thr Gln Pro Lys Asp Gly Val Glu Met Asp Ala Arg Ala 
    50                  55                  60                  


Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser 
65                  70                  75                  80  


Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Arg 
                85                  90                  95      


Glu Pro Pro Ala Glu Pro Ser Ile Tyr Ala Pro Leu Ala Ile His 
            100                 105                 110     


<210>  66
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  66

Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
1               5                   10                  15      


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
            20                  25                  30          


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
        35                  40                  45              


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
    50                  55                  60                  


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
65                  70                  75                  80  


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
                85                  90                  95      


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
            100                 105                 110         


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
        115                 120                 125             


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
    130                 135                 140                 


<210>  67
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala 
1               5                   10                  15      


Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg 
            20                  25                  30          


Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn 
        35                  40                  45              


Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met 
    50                  55                  60                  


Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala 
65                  70                  75                  80  


Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser 
                85                  90                  95      


Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu 
            100                 105                 110         


Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp 
        115                 120                 125             


Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
    130                 135                 140                 


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
145                 150                 155                 160 


Tyr Ala Thr Leu Ala Ile His 
                165         


<210>  68
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  68

Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg Asn Asp Val Thr 
1               5                   10                  15      


Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro 
            20                  25                  30          


Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala 
        35                  40                  45              


Thr Leu 
    50  


<210>  69
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  69

Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr 
1               5                   10                  15      


Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile 
            20                  25                  30          


Tyr Ala Thr Leu 
        35      


<210>  70
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIR1 ITIM

<400>  70

Asn Leu Tyr Ala Ala Val 
1               5       


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIR1 ITIM

<400>  71

Val Thr Tyr Ala Glu Val 
1               5       


<210>  72
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIR1 ITIM

<400>  72

Val Thr Tyr Ala Gln Leu 
1               5       


<210>  73
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LIR1 ITIM

<400>  73

Ser Ile Tyr Ala Thr Leu 
1               5       


<210>  74
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu 
1               5                   10                  15      


Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu 
            20                  25                  30          


Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys 
        35                  40                  45              


Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met 
    50                  55                  60                  


Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser 
65                  70                  75                  80  


Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
                85                  90                  95  


<210>  75
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  inhibitory domain

<400>  75

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Pro 
1               5                   10                  15      


Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp Lys Arg Arg Gly Arg 
            20                  25                  30          


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Pro Asp Pro Gln Glu 
        35                  40                  45              


Val Thr Tyr Ala Gln Leu Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    50                  55                  60                  


Gly His Pro Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu His Met Gln 
65                  70                  75                  80  


Ala Leu Pro Pro Arg 
                85  


<210>  76
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  76

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  77
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta transmembrande domain with D15K mutation

<400>  77

Leu Cys Tyr Leu Leu Lys Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  78
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta domain with D15R mutation

<400>  78

Leu Cys Tyr Leu Leu Arg Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  79
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 gamma transmembrane domaine with E122K mutation

<400>  79

Gly Phe Leu Phe Ala Lys Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  80
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha transmembrane domain with R288D mutation

<400>  80

Val Ile Gly Phe Asp Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  81
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 delta fused to CD28 stimulatory domain with GGS linker

<400>  81

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys Gly Gly Ser Arg Ser 
                165                 170                 175     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            180                 185                 190         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        195                 200                 205             


Asp Phe Ala Ala Tyr Arg Ser 
    210                 215 


<210>  82
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 delta fused to CD28 stimulatory domain with GGS linker

<400>  82
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaaggctgt ctggggctgc cgacacacaa      420

gctctgttga ggaatgacca ggtctatcag cccctccgag atcgagatga tgctcagtac      480

agccaccttg gaggaaactg ggctcggaac aagggcggaa gcaggagcaa gcggagcaga      540

ctgctgcaca gcgactacat gaacatgacc ccccggaggc ctggccccac ccggaagcac      600


<210>  83
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon fused to CD28 stimulatory domain with GGS linker

<400>  83

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile Gly 
        195                 200                 205             


Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    210                 215                 220                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
225                 230                 235                 240 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                245                 250     


<210>  84
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon fused to CD28 stimulatory domain with GGS linker

<400>  84
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

cctgtgacac gaggagcggg tgctggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccacctgttc ccaacccaga ctatgagccc atccggaaag gccagcggga cctgtattct      600

ggcctgaatc agcgcagaat cggcggaagc aggagcaagc ggagcagact gctgcacagc      660

gactacatga acatgacccc ccggaggcct ggccccaccc ggaagcacta ccagccctac      720


<210>  85
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 gamma fused to CD28 stimulatory domain with GGS linker

<400>  85

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn Gly Gly Ser Arg Ser Lys Arg Ser Arg Leu 
            180                 185                 190         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        195                 200                 205             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    210                 215                 220                 


Arg Ser 
225     


<210>  86
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 gamma fused to CD28 stimulatory domain with GGS linker

<400>  86
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctgaaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgcc agtcgagagc ttcagacaag cagactctgt tgcccaatga ccagctctac      480

cagcccctca aggatcgaga agatgaccag tacagccacc ttcaaggaaa ccagttgagg      540

aggaatggcg gaagcaggag caagcggagc agactgctgc acagcgacta catgaacatg      600

accccccgga ggcctggccc cacccggaag cactaccagc cctacgcccc tcccagggat      660


<210>  87
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4 extracellular domain, TCR alpha T48C extracellular 
       and transmembrane domains, CD28 stimulatory domain

<400>  87

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        275                 280                 285             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    290                 295                 300                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
305                 310                 315             


<210>  88
<211>  957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4 extracellular domain, TCR alpha T48C extracellular 
       and transmembrane domains, CD28 stimulatory domain

<400>  88
atggagacac tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctg      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggactca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtgaggcccc tctacggagg aagctacata      360

cctacatttg gaagaggaac cagccttatt gttcatccgt atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

tgtgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gcggcggaag caggagcaag      840

cggagcagac tgctgcacag cgactacatg aacatgaccc cccggaggcc tggccccacc      900

cggaagcact accagcccta cgcccctccc agggatttcg ccgcctaccg gagctag         957


<210>  89
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4 extracellular domain, TCR beta extracellular and 
       transmembrane domains, CD28 stimulatory domain

<400>  89

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Gly Gly Ser Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg 
        


<210>  90
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4 extracellular domain, TCR beta extracellular and 
       transmembrane domains, CD28 stimulatory domain

<400>  90
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg      900

atggccatgg tcaagagaaa ggattccaga ggcggcggaa gcaggagcaa gcggagcaga      960

ctgctgcaca gcgactacat gaacatgacc ccccggaggc ctggccccac ccggaagcac     1020


<210>  91
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 delta guide RNA targeting sequence

<400>  91
gguccaggau gcguuuuccc                                                   20


<210>  92
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 delta guide RNA targeting sequence

<400>  92
caucacaugg guagagggaa                                                   20


<210>  93
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 delta guide RNA targeting sequence

<400>  93
ccucuauagg uaucuugaag                                                   20


<210>  94
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon guide RNA targeting sequence

<400>  94
uuucagaucc aggauacuga                                                   20


<210>  95
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon guide RNA targeting sequence

<400>  95
gaugaggaug auaaaaacau                                                   20


<210>  96
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon guide RNA targeting sequence

<400>  96
uauuaugucu gcuaccccag                                                   20


<210>  97
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 gamma guide RNA targeting sequence

<400>  97
ucucauuuca ggaaaccacu                                                   20


<210>  98
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 gamma guide RNA targeting sequence

<400>  98
cagaagccaa aaauaucaca                                                   20


<210>  99
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 gamma guide RNA targeting sequence

<400>  99
auuuuuuuuu aucuucaguu                                                   20


<210>  100
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta guide RNA targeting sequence

<400>  100
gaaacucuuu guguaugugu                                                   20


<210>  101
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta guide RNA targeting sequence

<400>  101
acaguugccg auuacaggua                                                   20


<210>  102
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta guide RNA targeting sequence

<400>  102
aaaggacaag augaagugga                                                   20


<210>  103
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha transmembrane domain with R253E mutation

<400>  103

Val Ile Gly Phe Glu Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  104
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta transmembrane domain with K288D mutation

<400>  104

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Asp Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  105
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta transmembrane domain with K288E mutation

<400>  105

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Glu Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  106
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  106

Gly Ile Ile Val Thr Asp Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Phe Cys Phe Ala 
            20      


<210>  107
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D transmembrane domain with D137R mutation

<400>  107

Gly Ile Ile Val Thr Arg Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Phe Cys Phe Ala 
            20      


<210>  108
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D transmembrane domain with D137K mutation

<400>  108

Gly Ile Ile Val Thr Lys Val Ile Ala Thr Leu Leu Leu Ala Leu Gly 
1               5                   10                  15      


Val Phe Cys Phe Ala 
            20      


<210>  109
<211>  78
<212>  DNA
<213>  Homo sapiens

<400>  109
gtgatgtcgg tggccacaat tgtcatagtg gacatctgca tcactggggg cttgctgctg       60

ctggtttact actggagc                                                     78


<210>  110
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E transmembrane domain with D137R mutation

<400>  110

Val Met Ser Val Ala Thr Ile Val Ile Val Arg Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  111
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E transmembrane domain with D137K mutation

<400>  111

Val Met Ser Val Ala Thr Ile Val Ile Val Lys Ile Cys Ile Thr Gly 
1               5                   10                  15      


Gly Leu Leu Leu Leu Val Tyr Tyr Trp Ser 
            20                  25      


<210>  112
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  112

Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  113
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G transmembrane domain E122R mutation

<400>  113

Gly Phe Leu Phe Ala Arg Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  114
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G transmembrane domain with E122K mutation

<400>  114

Gly Phe Leu Phe Ala Lys Ile Val Ser Ile Phe Val Leu Ala Val Gly 
1               5                   10                  15      


Val Tyr Phe Ile Ala 
            20      


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITIM motif


<220>
<221>  X
<222>  (1)..(1)
<223>  X can be S, I, V or L

<220>
<221>  X
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (4)..(5)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (6)..(6)
<223>  X can be I, V or L

<400>  115

Xaa Xaa Tyr Xaa Xaa Xaa 
1               5       


<210>  116
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITSM motif


<220>
<221>  X
<222>  (2)..(2)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (4)..(5)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (6)..(6)
<223>  X can be V or I

<400>  116

Thr Xaa Tyr Xaa Xaa Xaa 
1               5       


<210>  117
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  117

Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser 
1               5                   10                  15      


Met Asp Phe Lys 
            20  


<210>  118
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 TCR alpha extracellular domain

<400>  118

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser 
                245                 


<210>  119
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 TCR beta extracellular domain

<400>  119

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala 
        275         


<210>  120
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  120
ggcatcattg tcactgatgt cattgccact ctgctccttg ctttgggagt cttctgcttt       60

gct                                                                     63


<210>  121
<211>  63
<212>  DNA
<213>  Homo sapiens

<400>  121
ggctttctct ttgctgaaat cgtcagcatt ttcgtccttg ctgttggggt ctacttcatt       60

gct                                                                     63


<210>  122
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  122
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg       60

cggctgtgg                                                               69


<210>  123
<211>  69
<212>  DNA
<213>  Homo sapiens

<400>  123
accatcctct atgagatctt gctagggaag gccaccttgt atgccgtgct ggtcagtgcc       60

ctcgtgctg                                                               69


<210>  124
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  124

Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu Pro Ala Gly Asp Arg 
1               5                   10                  15      


Thr Val Asn Arg Gln Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr 
            20                  25                  30          


Tyr Ala Gln Leu Asp His Cys Val Phe Ile Gln Arg Lys Ile Ser Arg 
        35                  40                  45              


Pro Ser Gln Arg Pro Lys Thr Pro Leu Thr Asp Thr Ser Val Tyr Thr 
    50                  55                  60                  


Glu Leu Pro Asn Ala Glu Pro Arg Ser Lys Val Val Ser Cys Pro Arg 
65                  70                  75                  80  


Ala Pro Gln Ser Gly Leu Glu Gly Val Phe 
                85                  90  


<210>  125
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM motif


<220>
<221>  X
<222>  (2)..(3)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (4)..(4)
<223>  X can be L or I

<400>  125

Tyr Xaa Xaa Xaa 
1               


<210>  126
<211>  269
<212>  DNA
<213>  Homo sapiens

<400>  126
ggacatgaga ctggaaggct gtctggggct gccgacacac aagctctgtt gaggaatgac       60

caggtctatc agcccctccg agatcgagat gatgctcagt acagccacct tggaggaaac      120

tgggctcgga acaagggcgg aagcaggagc aagcggagca gactgctgca cagcgactac      180

atgaacatga ccccccggag gcctggcccc acccggaagc actaccagcc ctacgcccct      240

cccagggatt tcgccgccta ccggagcta                                        269


<210>  127
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  127
aagaatagaa aggccaaggc caagcctgtg acacgaggag cgggtgctgg cggcaggcaa       60

aggggacaaa acaaggagag gccaccacct gttcccaacc cagactatga gcccatccgg      120

aaaggccagc gggacctgta ttctggcctg aatcagcgca gaatcggcgg aagcaggagc      180

aagcggagca gactgctgca cagcgactac atgaacatga ccccccggag gcctggcccc      240

acccggaagc actaccagcc ctacgcccct cccagggatt tcgccgccta ccggagctag      300


<210>  128
<211>  270
<212>  DNA
<213>  Homo sapiens

<400>  128
ggacaggatg gagttcgcca gtcgagagct tcagacaagc agactctgtt gcccaatgac       60

cagctctacc agcccctcaa ggatcgagaa gatgaccagt acagccacct tcaaggaaac      120

cagttgagga ggaatggcgg aagcaggagc aagcggagca gactgctgca cagcgactac      180

atgaacatga ccccccggag gcctggcccc acccggaagc actaccagcc ctacgcccct      240

cccagggatt tcgccgccta ccggagctag                                       270


<210>  129
<211>  30
<212>  DNA
<213>  Homo sapiens

<400>  129
atggccatgg tcaagagaaa ggattccaga                                        30


<210>  130
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  130
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  131
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  131
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag gccagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  132
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  132

Gln Leu Arg Lys Thr Gln Leu Leu Leu Glu Val Pro Pro Ser Thr Glu 
1               5                   10                  15      


Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu Arg Gly Glu Arg Ser 
            20                  25                  30          


Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp Val 
        35                  40                  


<210>  133
<211>  132
<212>  DNA
<213>  Homo sapiens

<400>  133
cagctgagga agacacagct gctgctggag gtgccgccgt cgaccgaaga cgccagaagc       60

tgccagttcc ccgaggaaga gcggggcgag cgatcggcag aggagaaggg gcggctgggg      120

gacctgtggg tg                                                          132


<210>  134
<211>  123
<212>  DNA
<213>  Homo sapiens

<400>  134
tgtgtcaggt gccggcaccg aaggcgccaa gcagagcgga tgtctcagat caagagactc       60

ctcagtgaga agaagacctg ccagtgtcct caccggtttc agaagacatg tagccccatt      120

tag                                                                    123


<210>  135
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  135
ctttactgca accacaggaa ccgaagacgt gtttgcaaat gtccccggcc tgtggtcaaa       60

tcgggagaca agcccagcct ttcggcgaga tacgtctag                              99


<210>  136
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  136
atgggctgtg tgcaatgtaa ggataaagaa gcaacaaaac tgacggagga gagggacggc       60

agcctgaacc agagctctgg gtaccgctat ggcacagacc ccacccctca gcactacccc      120

agcttcggtg tgacctccat ccccaactac aacaacttcc acgcagccgg gggccaagga      180

ctcaccgtct ttggaggtgt gaactcgtct tctcatacgg ggaccttgcg tacgagagga      240

ggaacaggag tgacactctt tgtggccctt tatgactatg aagcacggac agaagatgac      300

ctgagttttc acaaaggaga aaaatttcaa atattgaaca gctcggaagg agattggtgg      360

gaagcccgct ccttgacaac tggagagaca ggttacattc ccagcaatta tgtggctcca      420

gttgactcta tccaggcaga agagtggtac tttggaaaac ttggccgaaa agatgctgag      480

cgacagctat tgtcctttgg aaacccaaga ggtacctttc ttatccgcga gagtgaaacc      540

accaaaggtg cctattcact ttctatccgt gattgggatg atatgaaagg tgaccatgtc      600

aaacattata aaattcgcaa acttgacaat ggtggatact acattaccac ccgggcccag      660

tttgaaacac ttcagcagct tgtacaacat tactcagaga gagctgcagg actctgctgc      720

cgcctagtag ttccctgtca caaagggatg ccaaggctta ccgatctgtc tgtcaaaacc      780

aaagatgtct gggaaatccc tcgagaatcc ctgcagttga tcaagagact gggaaatggg      840

cagtttgggg aagtatggat gggtacctgg aatggaaaca caaaagtagc cataaagact      900

cttaaaccag gcacaatgtc ccccgaatca ttccttgagg aagcgcagat catgaagaag      960

ctgaagcacg acaagctggt ccagctctat gcagtggtgt ctgaggagcc catctacatc     1020

gtcaccgagt atatgaacaa aggaagttta ctggatttct taaaagatgg agaaggaaga     1080

gctctgaaat taccaaatct tgtggacatg gcagcacagg tggctgcagg aatggcttac     1140

atcgagcgca tgaattatat ccatagagat ctgcgatcag caaacattct agtggggaat     1200

ggactcatat gcaagattgc tgacttcgga ttggcccgat tgatagaaga caatgagtac     1260

acagcaagac aaggtgcaaa gttccccatc aagtggacgg cccccgaggc agccctgtac     1320

gggaggttca caatcaagtc tgacgtgtgg tcttttggaa tcttactcac agagctggtc     1380

accaaaggaa gagtgccata cccaggcatg aacaaccggg aggtgctgga gcaggtggag     1440

cgaggctaca ggatgccctg cccgcaggac tgccccatct ctctgcatga gctcatgatc     1500

cactgctgga aaaaggaccc tgaagaacgc cccacttttg agtacttgca gagcttcctg     1560

gaagactact ttaccgcgac agagccccag taccaacctg gtgaaaacct gtag           1614


<210>  137
<211>  1530
<212>  DNA
<213>  Homo sapiens

<400>  137
atgggctgtg gctgcagctc acacccggaa gatgactgga tggaaaacat cgatgtgtgt       60

gagaactgcc attatcccat agtcccactg gatggcaagg gcacgctgct catccgaaat      120

ggctctgagg tgcgggaccc actggttacc tacgaaggct ccaatccgcc ggcttcccca      180

ctgcaagaca acctggttat cgctctgcac agctatgagc cctctcacga cggagatctg      240

ggctttgaga agggggaaca gctccgcatc ctggagcaga gcggcgagtg gtggaaggcg      300

cagtccctga ccacgggcca ggaaggcttc atccccttca attttgtggc caaagcgaac      360

agcctggagc ccgaaccctg gttcttcaag aacctgagcc gcaaggacgc ggagcggcag      420

ctcctggcgc ccgggaacac tcacggctcc ttcctcatcc gggagagcga gagcaccgcg      480

ggatcgtttt cactgtcggt ccgggacttc gaccagaacc agggagaggt ggtgaaacat      540

tacaagatcc gtaatctgga caacggtggc ttctacatct cccctcgaat cacttttccc      600

ggcctgcatg aactggtccg ccattacacc aatgcttcag atgggctgtg cacacggttg      660

agccgcccct gccagaccca gaagccccag aagccgtggt gggaggacga gtgggaggtt      720

cccagggaga cactgaagct ggtggagcgg ctgggggctg gacagttcgg ggaggtgtgg      780

atggggtact acaacgggca cacgaaggtg gcggtgaaga gcctgaagca gggcagcatg      840

tccccggacg ccttcctggc cgaggccaac ctcatgaagc agctgcaaca ccagcggctg      900

gttcggctct acgctgtggt cacccaggag cccatctaca tcatcactga atacatggag      960

aatgggagtc tagtggattt tctcaagacc ccttcaggca tcaagttgac catcaacaaa     1020

ctcctggaca tggcagccca aattgcagaa ggcatggcat tcattgaaga gcggaattat     1080

attcatcgtg accttcgggc tgccaacatt ctggtgtctg acaccctgag ctgcaagatt     1140

gcagactttg gcctagcacg cctcattgag gacaacgagt acacagccag ggagggggcc     1200

aagtttccca ttaagtggac agcgccagaa gccattaact acgggacatt caccatcaag     1260

tcagatgtgt ggtcttttgg gatcctgctg acggaaattg tcacccacgg ccgcatccct     1320

tacccaggga tgaccaaccc ggaggtgatt cagaacctgg agcgaggcta ccgcatggtg     1380

cgccctgaca actgtccaga ggagctgtac caactcatga ggctgtgctg gaaggagcgc     1440

ccagaggacc ggcccacctt tgactacctg cgcagtgtgc tggaggactt cttcacggcc     1500

acagagggcc agtaccagcc tcagccttag                                      1530


<210>  138
<211>  1860
<212>  DNA
<213>  Homo sapiens

<400>  138
atgccagacc ccgcggcgca cctgcccttc ttctacggca gcatctcgcg tgccgaggcc       60

gaggagcacc tgaagctggc gggcatggcg gacgggctct tcctgctgcg ccagtgcctg      120

cgctcgctgg gcggctatgt gctgtcgctc gtgcacgatg tgcgcttcca ccactttccc      180

atcgagcgcc agctcaacgg cacctacgcc attgccggcg gcaaagcgca ctgtggaccg      240

gcagagctct gcgagttcta ctcgcgcgac cccgacgggc tgccctgcaa cctgcgcaag      300

ccgtgcaacc ggccgtcggg cctcgagccg cagccggggg tcttcgactg cctgcgagat      360

gccatggtgc gtgactacgt gcgccagacg tggaagctgg agggcgaggc cctggagcag      420

gccatcatca gccaggcccc gcaggtggag aagctcattg ctacgacggc ccacgagcgg      480

atgccctggt accacagcag cctgacgcgt gaggaggccg agcgcaaact ttactctggg      540

gcgcagaccg acggcaagtt cctgctgagg ccgcggaagg agcagggcac atacgccctg      600

tccctcatct atgggaagac ggtgtaccac tacctcatca gccaagacaa ggcgggcaag      660

tactgcattc ccgagggcac caagtttgac acgctctggc agctggtgga gtatctgaag      720

ctgaaggcgg acgggctcat ctactgcctg aaggaggcct gccccaacag cagtgccagc      780

aacgcctcag gggctgctgc tcccacactc ccagcccacc catccacgtt gactcatcct      840

cagcgaagaa tcgacaccct caactcagat ggatacaccc ctgagccagc acgcataacg      900

tccccagaca aaccgcggcc gatgcccatg gacacgagcg tgtatgagag cccctacagc      960

gacccagagg agctcaagga caagaagctc ttcctgaagc gcgataacct cctcatagct     1020

gacattgaac ttggctgcgg caactttggc tcagtgcgcc agggcgtgta ccgcatgcgc     1080

aagaagcaga tcgacgtggc catcaaggtg ctgaagcagg gcacggagaa ggcagacacg     1140

gaagagatga tgcgcgaggc gcagatcatg caccagctgg acaaccccta catcgtgcgg     1200

ctcattggcg tctgccaggc cgaggccctc atgctggtca tggagatggc tgggggcggg     1260

ccgctgcaca agttcctggt cggcaagagg gaggagatcc ctgtgagcaa tgtggccgag     1320

ctgctgcacc aggtgtccat ggggatgaag tacctggagg agaagaactt tgtgcaccgt     1380

gacctggcgg cccgcaacgt cctgctggtt aaccggcact acgccaagat cagcgacttt     1440

ggcctctcca aagcactggg tgccgacgac agctactaca ctgcccgctc agcagggaag     1500

tggccgctca agtggtacgc acccgaatgc atcaacttcc gcaagttctc cagccgcagc     1560

gatgtctgga gctatggggt caccatgtgg gaggccttgt cctacggcca gaagccctac     1620

aagaagatga aagggccgga ggtcatggcc ttcatcgagc agggcaagcg gatggagtgc     1680

ccaccagagt gtccacccga actgtacgca ctcatgagtg actgctggat ctacaagtgg     1740

gaggatcgcc ccgacttcct gaccgtggag cagcgcatgc gagcctgtta ctacagcctg     1800

gccagcaagg tggaagggcc cccaggcagc acacagaagg ctgaggctgc ctgtgcctag     1860


<210>  139
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  139

Pro Asn Ser Ser Ala Ser Asn Ala Ser Gly Ala Ala Ala Pro Thr Leu 
1               5                   10                  15      


Pro Ala His Pro Ser Thr Leu Thr His Pro Gln Arg Arg Ile Asp Thr 
            20                  25                  30          


Leu Asn Ser Asp Gly Tyr Thr Pro Glu Pro Ala Arg Ile Thr Ser Pro 
        35                  40                  45              


Asp Lys Pro Arg Pro Met Pro Met Asp Thr Ser Val Tyr Glu Ser Pro 
    50                  55                  60                  


Tyr Ser Asp Pro Glu Glu Leu Lys Asp Lys Lys Leu Phe Leu Lys Arg 
65                  70                  75                  80  


Asp Asn Leu Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly 
                85                  90                  95      


Ser Val Arg Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val 
            100                 105                 110         


Ala Ile Lys Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu 
        115                 120                 125             


Met Met Arg Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile 
    130                 135                 140                 


Val Arg Leu Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met 
145                 150                 155                 160 


Glu Met Ala Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg 
                165                 170                 175     


Glu Glu Ile Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser 
            180                 185                 190         


Met Gly Met Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu 
        195                 200                 205             


Ala Ala Arg Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser 
    210                 215                 220                 


Asp Phe Gly Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr 
225                 230                 235                 240 


Ala Arg Ser Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys 
                245                 250                 255     


Ile Asn Phe Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly 
            260                 265                 270         


Val Thr Met Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys 
        275                 280                 285             


Met Lys Gly Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met 
    290                 295                 300                 


Glu Cys Pro Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp 
305                 310                 315                 320 


Cys Trp Ile Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu 
                325                 330                 335     


Gln Arg Met Arg Ala Cys Tyr Tyr Ser Leu Ala Ser Lys Val Glu Gly 
            340                 345                 350         


Pro Pro Gly Ser Thr Gln Lys Ala Glu Ala Ala Cys Ala 
        355                 360                 365 


<210>  140
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  140

Leu Ile Ala Asp Ile Glu Leu Gly Cys Gly Asn Phe Gly Ser Val Arg 
1               5                   10                  15      


Gln Gly Val Tyr Arg Met Arg Lys Lys Gln Ile Asp Val Ala Ile Lys 
            20                  25                  30          


Val Leu Lys Gln Gly Thr Glu Lys Ala Asp Thr Glu Glu Met Met Arg 
        35                  40                  45              


Glu Ala Gln Ile Met His Gln Leu Asp Asn Pro Tyr Ile Val Arg Leu 
    50                  55                  60                  


Ile Gly Val Cys Gln Ala Glu Ala Leu Met Leu Val Met Glu Met Ala 
65                  70                  75                  80  


Gly Gly Gly Pro Leu His Lys Phe Leu Val Gly Lys Arg Glu Glu Ile 
                85                  90                  95      


Pro Val Ser Asn Val Ala Glu Leu Leu His Gln Val Ser Met Gly Met 
            100                 105                 110         


Lys Tyr Leu Glu Glu Lys Asn Phe Val His Arg Asp Leu Ala Ala Arg 
        115                 120                 125             


Asn Val Leu Leu Val Asn Arg His Tyr Ala Lys Ile Ser Asp Phe Gly 
    130                 135                 140                 


Leu Ser Lys Ala Leu Gly Ala Asp Asp Ser Tyr Tyr Thr Ala Arg Ser 
145                 150                 155                 160 


Ala Gly Lys Trp Pro Leu Lys Trp Tyr Ala Pro Glu Cys Ile Asn Phe 
                165                 170                 175     


Arg Lys Phe Ser Ser Arg Ser Asp Val Trp Ser Tyr Gly Val Thr Met 
            180                 185                 190         


Trp Glu Ala Leu Ser Tyr Gly Gln Lys Pro Tyr Lys Lys Met Lys Gly 
        195                 200                 205             


Pro Glu Val Met Ala Phe Ile Glu Gln Gly Lys Arg Met Glu Cys Pro 
    210                 215                 220                 


Pro Glu Cys Pro Pro Glu Leu Tyr Ala Leu Met Ser Asp Cys Trp Ile 
225                 230                 235                 240 


Tyr Lys Trp Glu Asp Arg Pro Asp Phe Leu Thr Val Glu Gln Arg Met 
                245                 250                 255     


Arg Ala Cys Tyr Tyr Ser Leu 
            260             


<210>  141
<211>  702
<212>  DNA
<213>  Homo sapiens

<400>  141
atggaggagg ccatcctggt cccctgcgtg ctggggctcc tgctgctgcc catcctggcc       60

atgttgatgg cactgtgtgt gcactgccac agactgccag gctcctacga cagcacatcc      120

tcagatagtt tgtatccaag gggcatccag ttcaaacggc ctcacacggt tgccccctgg      180

ccacctgcct acccacctgt cacctcctac ccacccctga gccagccaga cctgctcccc      240

atcccaagat ccccgcagcc ccttgggggc tcccaccgga cgccatcttc ccggcgggat      300

tctgatggtg ccaacagtgt ggcgagctac gagaacgagg aaccagcctg tgaggatgcg      360

gatgaggatg aggacgacta tcacaaccca ggctacctgg tggtgcttcc tgacagcacc      420

ccggccacta gcactgctgc cccatcagct cctgcactca gcacccctgg catccgagac      480

agtgccttct ccatggagtc cattgatgat tacgtgaacg ttccggagag cggggagagc      540

gcagaagcgt ccctggatgg cagccgggag tatgtgaatg tgtcccagga actgcatcct      600

ggagcggcta agactgagcc tgccgccctg agttcccagg aggcagagga agtggaggaa      660

gagggggctc cagattacga gaatctgcag gagctgaact ag                         702


<210>  142
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  142
atggcactga ggaatgtgcc ctttcgctca gaggtcctgg gctgggaccc cgacagcctt       60

gctgactatt tcaagaagct caactataag gactgtgaga aggcagtgaa gaagtaccac      120

atcgatgggg ctcgcttctt gaacctgaca gaaaatgaca tccagaagtt ccccaagctc      180

cgggtgccga ttctcagtaa gttaagtcag gaaatcaaca agaacgaaga gaggaggagc      240

atcttcacac gcaaacccca agtcccgcgg tttcctgaag agacagaaag ccacgaagag      300

gacaatgggg gctggtcgtc ctttgaagaa gacgattatg aaagtcccaa tgatgaccag      360

gatggggagg atgatggaga ctatgagtcc cccaatgagg aggaagaggc acccgtggaa      420

gatgacgcgg attatgagcc gccaccctcc aatgacgagg aagctctgca gaactccatc      480

ctgcctgcca agcctttccc caactccaac tccatgtaca tcgaccggcc cccctctggg      540

aaaacccccc agcagcctcc tgtgcccccc cagaggccga tggccgccct cccgccccca      600

ccagccggcc ggaatcactc gccactgccc ccaccccaga ccaaccacga agaacccagc      660

agaagcagaa accacaaaac ggcaaagctc cctgctcctt caatagacag aagcacgaaa      720

cctcccctag atcgttcatt agctccgttt gatagagaac ccttcacact aggaaagaaa      780

ccaccatttt ctgacaagcc ctcgattcca gcgggaaggt cactcgggga gcatttaccc      840

aagattcaaa agcctccttt accaccgacc acggaaagac atgaaaggag cagccccctg      900

ccagggaaga agccacctgt gccaaagcat ggatggggac cagacagaag agagaatgat      960

gaagatgatg tgcatcagag gcctttgccc cagccagcac tacttcctat gagctccaac     1020

actttccctt caagatctac taagccaagt cccatgaacc ctctcccatc ctctcacatg     1080

cctggagcat tctcagaaag taacagcagt tttccacaga gtgcctccct gccaccatac     1140

ttctctcaag gccctagcaa cagaccacct atcagagccg aaggcagaaa cttccccttg     1200

ccacttccaa acaaacctcg gcccccatcc cccgcggagg aagagaattc attaaatgaa     1260

gagtggtacg tttcttatat tacccgacca gaggcagaag ctgctcttag aaagataaac     1320

caggatggca catttctggt cagagacagc tctaaaaaaa caacaaccaa tccatatgtc     1380

ctcatggtgt tgtacaaaga taaagtttac aacatccaga tccgttatca gaaggaaagt     1440

caagtttact tgttgggaac tggactccga gggaaagagg actttctgtc tgtgtcagat     1500

attattgact acttcaggaa aatgccactt ctgctcattg atgggaaaaa ccgaggttcc     1560

agataccagt gcacattaac gcatgctgca gggtacccat ag                        1602


<210>  143
<211>  270
<212>  DNA
<213>  Homo sapiens

<400>  143
aacaaaaaga atgctgctgt aatggaccaa gagcctgcgg gggacagaac agtgaatagg       60

caggactctg atgaacaaga ccctcaggag gtgacgtacg cacagttgga tcactgcgtt      120

ttcatacaga gaaaaatcag tcgcccttct cagaggccca agacacccct aacagatacc      180

agcgtgtaca cggaacttcc aaatgctgag cccagatcca aagttgtctc ctgcccacga      240

gcaccacagt caggtcttga gggggttttc                                       270


<210>  144
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 delta fused to CD28 ICD with GGS linker

<400>  144

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys Gly Gly Ser Arg Ser 
                165                 170                 175     


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
            180                 185                 190         


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
        195                 200                 205             


Asp Phe Ala Ala Tyr Arg Ser 
    210                 215 


<210>  145
<211>  647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 delta fused to CD28 ICD with GGS linker

<400>  145
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaaggctgt ctggggctgc cgacacacaa      420

gctctgttga ggaatgacca ggtctatcag cccctccgag atcgagatga tgctcagtac      480

agccaccttg gaggaaactg ggctcggaac aagggcggaa gcaggagcaa gcggagcaga      540

ctgctgcaca gcgactacat gaacatgacc ccccggaggc ctggccccac ccggaagcac      600

taccagccct acgcccctcc cagggatttc gccgcctacc ggagcta                    647


<210>  146
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon fused to CD28 ICD with GGS linker

<400>  146

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile Gly 
        195                 200                 205             


Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
    210                 215                 220                 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
225                 230                 235                 240 


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                245                 250     


<210>  147
<211>  756
<212>  DNA
<213>  Artificial Seqeunce

<220>
<223>  CD3 epsilon fused to CD28 ICD with GGS linker

<400>  147
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

cctgtgacac gaggagcggg tgctggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccacctgttc ccaacccaga ctatgagccc atccggaaag gccagcggga cctgtattct      600

ggcctgaatc agcgcagaat cggcggaagc aggagcaagc ggagcagact gctgcacagc      660

gactacatga acatgacccc ccggaggcct ggccccaccc ggaagcacta ccagccctac      720

gcccctccca gggatttcgc cgcctaccgg agctag                                756


<210>  148
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 gamma fused to CD28 ICD with GGS linker

<400>  148

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn Gly Gly Ser Arg Ser Lys Arg Ser Arg Leu 
            180                 185                 190         


Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr 
        195                 200                 205             


Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr 
    210                 215                 220                 


Arg Ser 
225     


<210>  149
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 gamma fused to CD28 ICD with GGS linker

<400>  149
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctgaaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgcc agtcgagagc ttcagacaag cagactctgt tgcccaatga ccagctctac      480

cagcccctca aggatcgaga agatgaccag tacagccacc ttcaaggaaa ccagttgagg      540

aggaatggcg gaagcaggag caagcggagc agactgctgc acagcgacta catgaacatg      600

accccccgga ggcctggccc cacccggaag cactaccagc cctacgcccc tcccagggat      660

ttcgccgcct accggagcta g                                                681


<210>  150
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4, TCR alpha T48C transmembrane domain, CD28 
       intracellular domain linked to TCR alpha with a GGS linker

<400>  150

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Gly Ser Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
        275                 280                 285             


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
    290                 295                 300                 


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
305                 310                 315             


<210>  151
<211>  957
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4, TCR alpha T48C transmembrane domain,  CD28 
       intracellular domain linked to TCR alpha with a GGS linker

<400>  151
atggagacac tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctg      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggactca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtgaggcccc tctacggagg aagctacata      360

cctacatttg gaagaggaac cagccttatt gttcatccgt atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

tgtgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gcggcggaag caggagcaag      840

cggagcagac tgctgcacag cgactacatg aacatgaccc cccggaggcc tggccccacc      900

cggaagcact accagcccta cgcccctccc agggatttcg ccgcctaccg gagctag         957


<210>  152
<211>  355
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4,TCR beta transmembrane domain, CD28 intracellular 
       domain linked to TCR alpha with a GGS linker

<400>  152

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Gly Gly Ser Arg Ser Lys Arg Ser Arg 
305                 310                 315                 320 


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
                325                 330                 335     


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
            340                 345                 350         


Tyr Arg Ser 
        355 


<210>  153
<211>  1068
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NY-ESO1 1G4, TCR beta transmembrane domain, CD28 intracellular 
       domain linked to TCR alpha with a GGS linker

<400>  153
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg      900

atggccatgg tcaagagaaa ggattccaga ggcggcggaa gcaggagcaa gcggagcaga      960

ctgctgcaca gcgactacat gaacatgacc ccccggaggc ctggccccac ccggaagcac     1020

taccagccct acgcccctcc cagggatttc gccgcctacc ggagctag                  1068


<210>  154
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory CD3z

<400>  154

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Lys 
                165                 170                 175     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Pro Asp Pro Gln 
            180                 185                 190         


Glu Val Thr Tyr Ala Gln Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        195                 200                 205             


Met Gly Gly Lys Pro Arg Arg Lys Pro Asp Pro Gln Glu Val Thr Tyr 
    210                 215                 220                 


Ala Gln Leu Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Pro 
225                 230                 235                 240 


Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu His Met Gln Ala Leu Pro 
                245                 250                 255     


Pro Arg 
        


<210>  155
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory CD3z

<400>  155

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg His Arg 
                165                 170                 175     


Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln 
            180                 185                 190         


His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln 
        195                 200                 205             


Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala 
    210                 215                 220                 


Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg 
225                 230                 235                 240 


Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys 
                245                 250                 255     


His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser 
            260                 265                 270         


Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln 
        275                 280                 285             


Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr 
    290                 295                 300                 


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro 
305                 310                 315                 320 


Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr 
                325                 330                 335     


Leu Ala Ile His 
            340 


<210>  156
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory CD3z

<400>  156

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Pro Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp Lys Arg 
65                  70                  75                  80  


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Pro Asp 
                85                  90                  95      


Pro Gln Glu Val Thr Tyr Ala Gln Leu Gly Met Lys Gly Glu Arg Arg 
            100                 105                 110         


Arg Gly Lys Gly His Pro Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
        115                 120                 125             


His Met Gln Ala Leu Pro Pro Arg 
    130                 135     


<210>  157
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha and PD1 intracellular domain fusion protein

<400>  157

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg 
    290                 295                 300                 


Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
305                 310                 315                 320 


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
                325                 330                 335     


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
            340                 345                 350         


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
        355                 360                 365             


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
    370                 375                 380                 


Cys Ser Trp Pro Leu 
385                 


<210>  158
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha and KIRDL2 intracellular domain fusion protein

<400>  158

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln 
    290                 295                 300                 


Glu Pro Ala Gly Asp Arg Thr Val Asn Arg Gln Asp Ser Asp Glu Gln 
305                 310                 315                 320 


Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Val Phe Ile 
                325                 330                 335     


Gln Arg Lys Ile Ser Arg Pro Ser Gln Arg Pro Lys Thr Pro Leu Thr 
            340                 345                 350         


Asp Thr Ser Val Tyr Thr Glu Leu Pro Asn Ala Glu Pro Arg Ser Lys 
        355                 360                 365             


Val Val Ser Cys Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly Val Phe 
    370                 375                 380                 


<210>  159
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha and LIR1 intracellular domain fusion protein

<400>  159

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Arg His Arg Arg Gln Gly Lys His Trp Thr 
    290                 295                 300                 


Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly 
305                 310                 315                 320 


Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala 
                325                 330                 335     


Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro 
            340                 345                 350         


Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro 
        355                 360                 365             


Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu 
    370                 375                 380                 


Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys 
385                 390                 395                 400 


Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala 
                405                 410                 415     


Ser Glu Ala Pro Gln Asp Ser Ala Ile His 
            420                 425     


<210>  160
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory CD3 zeta

<400>  160

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    290                 295                 300                 


Pro Ala Tyr Gln Gln Pro Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
305                 310                 315                 320 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
                325                 330                 335     


Lys Pro Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Gly Met Lys Gly 
            340                 345                 350         


Glu Arg Arg Arg Gly Lys Gly His Pro Asp Pro Gln Glu Val Thr Tyr 
        355                 360                 365             


Ala Gln Leu His Met Gln Ala Leu Pro Pro Arg 
    370                 375                 


<210>  161
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta and PD1 intracellular domain fusion protein

<400>  161

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg 
                325                 330                 335     


Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe 
            340                 345                 350         


Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro 
        355                 360                 365             


Glu Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile 
    370                 375                 380                 


Val Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser 
385                 390                 395                 400 


Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His 
                405                 410                 415     


Cys Ser Trp Pro Leu 
            420     


<210>  162
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta and KIR3DL2 intracellular domain fusion protein

<400>  162

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln 
                325                 330                 335     


Glu Pro Ala Gly Asp Arg Thr Val Asn Arg Gln Asp Ser Asp Glu Gln 
            340                 345                 350         


Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Asp His Cys Val Phe Ile 
        355                 360                 365             


Gln Arg Lys Ile Ser Arg Pro Ser Gln Arg Pro Lys Thr Pro Leu Thr 
    370                 375                 380                 


Asp Thr Ser Val Tyr Thr Glu Leu Pro Asn Ala Glu Pro Arg Ser Lys 
385                 390                 395                 400 


Val Val Ser Cys Pro Arg Ala Pro Gln Ser Gly Leu Glu Gly Val Phe 
                405                 410                 415     


<210>  163
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta and LIR1 intracellular domain fusion protein

<400>  163

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Arg His Arg Arg Gln Gly Lys His Trp Thr 
                325                 330                 335     


Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly 
            340                 345                 350         


Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala 
        355                 360                 365             


Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro 
    370                 375                 380                 


Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro 
385                 390                 395                 400 


Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu 
                405                 410                 415     


Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys 
            420                 425                 430         


Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala 
        435                 440                 445             


Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr 
    450                 455                 460                 


Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser 
465                 470                 475                 480 


Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
                485                 490             


<210>  164
<211>  411
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic inhibitory CD3 zeta

<400>  164

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Gln Gln Pro Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
            340                 345                 350         


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
        355                 360                 365             


Lys Pro Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu Gly Met Lys Gly 
    370                 375                 380                 


Glu Arg Arg Arg Gly Lys Gly His Pro Asp Pro Gln Glu Val Thr Tyr 
385                 390                 395                 400 


Ala Gln Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410     


<210>  165
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR alpha and PD1 intracellular domain fusion protein

<400>  165
atggagacac tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctg      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggactca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtgaggcccc tctacggagg aagctacata      360

cctacatttg gaagaggaac cagccttatt gttcatccgt atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

tgtgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gcggcggagg tggaagcgga      840

gggggaggat ctggcggcgg aggaagcgga ggcggcgggt cccgggccgc acgagggaca      900

ataggagcca ggcgcaccgg ccagcccctg aaggaggacc cctcagccgt gcctgtgttc      960

tctgtggact atggggagct ggatttccag tggcgagaga agaccccgga gccccccgtg     1020

ccctgtgtcc ctgagcagac ggagtatgcc accattgtct ttcctagcgg aatgggcacc     1080

tcatcccccg cccgcagggg ctcagctgac ggccctcgga gtgcccagcc actgaggcct     1140

gaggatggac actgctcttg gcccctc                                         1167


<210>  166
<211>  1152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR alpha and KIR3DL2 intracellular domain fusion protein

<400>  166
atggagacac tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctg      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggactca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtgaggcccc tctacggagg aagctacata      360

cctacatttg gaagaggaac cagccttatt gttcatccgt atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

tgtgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gcggcggagg tggaagcgga      840

gggggaggat ctggcggcgg aggaagcgga ggcggcgggt ccaacaaaaa gaatgctgct      900

gtaatggacc aagagcctgc gggggacaga acagtgaata ggcaggactc tgatgaacaa      960

gaccctcagg aggtgacgta cgcacagttg gatcactgcg ttttcataca gagaaaaatc     1020

agtcgccctt ctcagaggcc caagacaccc ctaacagata ccagcgtgta cacggaactt     1080

ccaaatgctg agcccagatc caaagttgtc tcctgcccac gagcaccaca gtcaggtctt     1140

gagggggttt tc                                                         1152


<210>  167
<211>  1383
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR alpha and LIR1 intracellular domain fusion protein

<400>  167
atggagacac tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctg      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggactca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtgaggcccc tctacggagg aagctacata      360

cctacatttg gaagaggaac cagccttatt gttcatccgt atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

tgtgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcc gaatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gcggcggagg tggaagcgga      840

gggggaggat ctggcggcgg aggaagcgga ggcggcgggt cccgacatcg acgtcagggc      900

aaacactgga catcgaccca gagaaaggct gatttccaac atcctgcagg ggctgtgggg      960

ccagagccca cagacagagg cctgcagtgg aggtccagcc cagctgccga tgcccaggaa     1020

gaaaacctct atgctgccgt gaagcacaca cagcctgagg atggggtgga gatggacact     1080

cggagcccac acgatgaaga cccccaggca gtgacgtatg ccgaggtgaa acactccaga     1140

cctaggagag aaatggcctc tcctccttcc ccactgtctg gggaattcct ggacacaaag     1200

gacagacagg cggaagagga caggcagatg gacactgagg ctgctgcatc tgaagccccc     1260

caggatgtga cctacgccca gctgcacagc ttgaccctca gacgggaggc aactgagcct     1320

cctccatccc aggaagggcc ctctccagct gtgcccagca tctacgccac tctggccatc     1380

cac                                                                   1383


<210>  168
<211>  1263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR beta and PD1 intracellular domain fusion protein

<400>  168
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg      900

atggccatgg tcaagagaaa ggattccaga ggcggagggg gaggatctgg cggcggagga      960

agcggaggcg gcgggtcccg ggccgcacga gggacaatag gagccaggcg caccggccag     1020

cccctgaagg aggacccctc agccgtgcct gtgttctctg tggactatgg ggagctggat     1080

ttccagtggc gagagaagac cccggagccc cccgtgccct gtgtccctga gcagacggag     1140

tatgccacca ttgtctttcc tagcggaatg ggcacctcat cccccgcccg caggggctca     1200

gctgacggcc ctcggagtgc ccagccactg aggcctgagg atggacactg ctcttggccc     1260

ctc                                                                   1263


<210>  169
<211>  1248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR beta and KIR3DL2 intracellular domain fusion protein

<400>  169
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg      900

atggccatgg tcaagagaaa ggattccaga ggcggagggg gaggatctgg cggcggagga      960

agcggaggcg gcgggtccaa caaaaagaat gctgctgtaa tggaccaaga gcctgcgggg     1020

gacagaacag tgaataggca ggactctgat gaacaagacc ctcaggaggt gacgtacgca     1080

cagttggatc actgcgtttt catacagaga aaaatcagtc gcccttctca gaggcccaag     1140

acacccctaa cagataccag cgtgtacacg gaacttccaa atgctgagcc cagatccaaa     1200

gttgtctcct gcccacgagc accacagtca ggtcttgagg gggttttc                  1248


<210>  170
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR beta and LIR1 intracellular domain fusion protein

<400>  170
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatct tgctagggaa ggccaccttg tatgccgtgc tggtcagtgc cctcgtgctg      900

atggccatgg tcaagagaaa ggattccaga ggcggagggg gaggatctgg cggcggagga      960

agcggaggcg gcgggtcccg acatcgacgt cagggcaaac actggacatc gacccagaga     1020

aaggctgatt tccaacatcc tgcaggggct gtggggccag agcccacaga cagaggcctg     1080

cagtggaggt ccagcccagc tgccgatgcc caggaagaaa acctctatgc tgccgtgaag     1140

cacacacagc ctgaggatgg ggtggagatg gacactcgga gcccacacga tgaagacccc     1200

caggcagtga cgtatgccga ggtgaaacac tccagaccta ggagagaaat ggcctctcct     1260

ccttccccac tgtctgggga attcctggac acaaaggaca gacaggcgga agaggacagg     1320

cagatggaca ctgaggctgc tgcatctgaa gccccccagg atgtgaccta cgcccagctg     1380

cacagcttga ccctcagacg ggaggcaact gagcctcctc catcccagga agggccctct     1440

ccagctgtgc ccagcatcta cgccactctg gccatccac                            1479


<210>  171
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D with ITAM deletion

<400>  171

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg 
    130         


<210>  172
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E with ITAM deletion

<400>  172

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


<210>  173
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G with ITAM deletion

<400>  173

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg 
    130                 135                 140             


<210>  174
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z with ITAM deletion

<400>  174

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala 
    50                  55                  


<210>  175
<211>  396
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3D with ITAM deletion

<400>  175
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaagg                                396


<210>  176
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3E with ITAM deletion

<400>  176
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480


<210>  177
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3G with ITAM deletion

<400>  177
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctgaaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgc                                                              429


<210>  178
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z with ITAM deletion

<400>  178
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctggatgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgca         177


<210>  179
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D and PD1 intracellular domain fusion protein

<400>  179

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro 
    130                 135                 140                 


Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly 
145                 150                 155                 160 


Val Val Gly Gly Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu 
                165                 170                 175     


Ala Val Ile Cys Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg 
            180                 185                 190         


Thr Gly Gln Pro Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser 
        195                 200                 205             


Val Asp Tyr Gly Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu 
    210                 215                 220                 


Pro Pro Val Pro Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val 
225                 230                 235                 240 


Phe Pro Ser Gly Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala 
                245                 250                 255     


Asp Gly Pro Arg Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys 
            260                 265                 270         


Ser Trp Pro Leu 
        275     


<210>  180
<211>  304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E and PD1 intracellular domain fusion protein

<400>  180

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
                165                 170                 175     


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
            180                 185                 190         


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
        195                 200                 205             


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
    210                 215                 220                 


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
225                 230                 235                 240 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
                245                 250                 255     


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
            260                 265                 270         


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
        275                 280                 285             


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
    290                 295                 300                 


<210>  181
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G and PD1 intracellular domain fusion protein

<400>  181

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Thr 
    130                 135                 140                 


Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg 
145                 150                 155                 160 


Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu 
                165                 170                 175     


Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser 
            180                 185                 190         


Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu 
        195                 200                 205             


Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu 
    210                 215                 220                 


Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys 
225                 230                 235                 240 


Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met 
                245                 250                 255     


Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser 
            260                 265                 270         


Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285         


<210>  182
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z and PD1 intracellular domain fusion protein

<400>  182

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Thr Glu Arg Arg Ala 
    50                  55                  60                  


Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln 
65                  70                  75                  80  


Phe Gln Thr Leu Val Val Gly Val Val Gly Gly Leu Leu Gly Ser Leu 
                85                  90                  95      


Val Leu Leu Val Trp Val Leu Ala Val Ile Cys Ser Arg Ala Ala Arg 
            100                 105                 110         


Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro Leu Lys Glu Asp Pro 
        115                 120                 125             


Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly Glu Leu Asp Phe Gln 
    130                 135                 140                 


Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro Cys Val Pro Glu Gln 
145                 150                 155                 160 


Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly Met Gly Thr Ser Ser 
                165                 170                 175     


Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg Ser Ala Gln Pro Leu 
            180                 185                 190         


Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        195                 200             


<210>  183
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D and LIR1 ICD fusion protein

<400>  183

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
    130                 135                 140                 


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
145                 150                 155                 160 


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
                165                 170                 175     


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
            180                 185                 190         


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
        195                 200                 205             


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
    210                 215                 220                 


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
225                 230                 235                 240 


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
                245                 250                 255     


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
            260                 265                 270         


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
        275                 280                 285             


Ile Tyr Ala Thr Leu Ala Ile His 
    290                 295     


<210>  184
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E and LIR1 intracellular domain fusion protein

<400>  184

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Arg His Arg Arg Gln 
145                 150                 155                 160 


Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro 
                165                 170                 175     


Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg 
            180                 185                 190         


Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val 
        195                 200                 205             


Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro 
    210                 215                 220                 


His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser 
225                 230                 235                 240 


Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu 
                245                 250                 255     


Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp 
            260                 265                 270         


Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln 
        275                 280                 285             


Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser 
    290                 295                 300                 


Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala 
305                 310                 315                 320 


Ile His 
        


<210>  185
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G and LIR1 intracellular domain fusion protein

<400>  185

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Arg His Arg Arg Gln Gly 
    130                 135                 140                 


Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala 
145                 150                 155                 160 


Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser 
                165                 170                 175     


Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys 
            180                 185                 190         


His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His 
        195                 200                 205             


Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg 
    210                 215                 220                 


Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe 
225                 230                 235                 240 


Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr 
                245                 250                 255     


Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu 
            260                 265                 270         


His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln 
        275                 280                 285             


Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile 
    290                 295                 300                 


His 
305 


<210>  186
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z and LIR1 intracellular domain fusion protein

<400>  186

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Arg His Arg Arg Gln Gly Lys His Trp 
    50                  55                  60                  


Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro Ala Gly Ala Val 
65                  70                  75                  80  


Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala 
                85                  90                  95      


Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val Lys His Thr Gln 
            100                 105                 110         


Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro His Asp Glu Asp 
        115                 120                 125             


Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser Arg Pro Arg Arg 
    130                 135                 140                 


Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr 
145                 150                 155                 160 


Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp Thr Glu Ala Ala 
                165                 170                 175     


Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln Leu His Ser Leu 
            180                 185                 190         


Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro 
        195                 200                 205             


Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala Ile His 
    210                 215                 220         


<210>  187
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D LIR1 fusion protein

<400>  187

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu 
145                 150                 155                 160 


Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro 
                165                 170                 175     


Ser Ile Tyr Ala Thr Leu Gly Gly Asn Trp Ala Arg Asn Lys 
            180                 185                 190 


<210>  188
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E LIR1 fusion protein

<400>  188

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Val Thr Tyr Ala Gln Leu His 
            180                 185                 190         


Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu 
        195                 200                 205             


Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Asn Gln Arg 
    210                 215                 220                 


Arg Ile 
225     


<210>  189
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G LIR1 fusion protein

<400>  189

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Val Thr Tyr 
145                 150                 155                 160 


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro 
                165                 170                 175     


Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr 
            180                 185                 190         


Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        195                 200     


<210>  190
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z LIR1 fusion protein

<400>  190

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu 
65                  70                  75                  80  


Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro 
                85                  90                  95      


Ala Val Pro Ser Ile Tyr Ala Thr Leu Asp Lys Arg Arg Gly Arg Asp 
            100                 105                 110         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Val Thr 
        115                 120                 125             


Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro 
    130                 135                 140                 


Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala 
145                 150                 155                 160 


Thr Leu Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Val 
                165                 170                 175     


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu 
            180                 185                 190         


Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr 
        195                 200                 205             


Ala Thr Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 


<210>  191
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3D and PD1 intracellular domain fusion protein

<400>  191
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaaggacag agagaagggc agaagtgccc      420

acagcccacc ccagcccctc acccaggcca gccggccagt tccaaaccct ggtggttggt      480

gtcgtgggcg gcctgctggg cagcctggtg ctgctagtct gggtcctggc cgtcatctgc      540

tcccgggccg cacgagggac aataggagcc aggcgcaccg gccagcccct gaaggaggac      600

ccctcagccg tgcctgtgtt ctctgtggac tatggggagc tggatttcca gtggcgagag      660

aagaccccgg agccccccgt gccctgtgtc cctgagcaga cggagtatgc caccattgtc      720

tttcctagcg gaatgggcac ctcatccccc gcccgcaggg gctcagctga cggccctcgg      780

agtgcccagc cactgaggcc tgaggatgga cactgctctt ggcccctc                   828


<210>  192

<400>  192
000

<210>  193
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3E and PD1 intracellular domain fusion protein

<400>  193
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

acagagagaa gggcagaagt gcccacagcc caccccagcc cctcacccag gccagccggc      540

cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc tgggcagcct ggtgctgcta      600

gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag ggacaatagg agccaggcgc      660

accggccagc ccctgaagga ggacccctca gccgtgcctg tgttctctgt ggactatggg      720

gagctggatt tccagtggcg agagaagacc ccggagcccc ccgtgccctg tgtccctgag      780

cagacggagt atgccaccat tgtctttcct agcggaatgg gcacctcatc ccccgcccgc      840

aggggctcag ctgacggccc tcggagtgcc cagccactga ggcctgagga tggacactgc      900

tcttggcccc tc                                                          912


<210>  194
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3G and PD1 intracellular domain fusion protein

<400>  194
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctgaaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgca cagagagaag ggcagaagtg cccacagccc accccagccc ctcacccagg      480

ccagccggcc agttccaaac cctggtggtt ggtgtcgtgg gcggcctgct gggcagcctg      540

gtgctgctag tctgggtcct ggccgtcatc tgctcccggg ccgcacgagg gacaatagga      600

gccaggcgca ccggccagcc cctgaaggag gacccctcag ccgtgcctgt gttctctgtg      660

gactatgggg agctggattt ccagtggcga gagaagaccc cggagccccc cgtgccctgt      720

gtccctgagc agacggagta tgccaccatt gtctttccta gcggaatggg cacctcatcc      780

cccgcccgca ggggctcagc tgacggccct cggagtgccc agccactgag gcctgaggat      840

ggacactgct cttggcccct c                                                861


<210>  195
<211>  609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z and PD1 intracellular domain fusion protein

<400>  195
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctggatgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcaaca      180

gagagaaggg cagaagtgcc cacagcccac cccagcccct cacccaggcc agccggccag      240

ttccaaaccc tggtggttgg tgtcgtgggc ggcctgctgg gcagcctggt gctgctagtc      300

tgggtcctgg ccgtcatctg ctcccgggcc gcacgaggga caataggagc caggcgcacc      360

ggccagcccc tgaaggagga cccctcagcc gtgcctgtgt tctctgtgga ctatggggag      420

ctggatttcc agtggcgaga gaagaccccg gagccccccg tgccctgtgt ccctgagcag      480

acggagtatg ccaccattgt ctttcctagc ggaatgggca cctcatcccc cgcccgcagg      540

ggctcagctg acggccctcg gagtgcccag ccactgaggc ctgaggatgg acactgctct      600

tggcccctc                                                              609


<210>  196
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3D and LIR1 intracellular domain fusion protein

<400>  196
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagcga catcgacgtc agggcaaaca ctggacatcg      420

acccagagaa aggctgattt ccaacatcct gcaggggctg tggggccaga gcccacagac      480

agaggcctgc agtggaggtc cagcccagct gccgatgccc aggaagaaaa cctctatgct      540

gccgtgaagc acacacagcc tgaggatggg gtggagatgg acactcggag cccacacgat      600

gaagaccccc aggcagtgac gtatgccgag gtgaaacact ccagacctag gagagaaatg      660

gcctctcctc cttccccact gtctggggaa ttcctggaca caaaggacag acaggcggaa      720

gaggacaggc agatggacac tgaggctgct gcatctgaag ccccccagga tgtgacctac      780

gcccagctgc acagcttgac cctcagacgg gaggcaactg agcctcctcc atcccaggaa      840

gggccctctc cagctgtgcc cagcatctac gccactctgg ccatccac                   888


<210>  197
<211>  966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3E and LIR1 intracellular domain fusion protein

<400>  197
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagacgaca tcgacgtcag      480

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg      540

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag      600

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggac      660

actcggagcc cacacgatga agacccccag gcagtgacgt atgccgaggt gaaacactcc      720

agacctagga gagaaatggc ctctcctcct tccccactgt ctggggaatt cctggacaca      780

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagcc      840

ccccaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag      900

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc      960

atccac                                                                 966


<210>  198
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3G and LIR1 intracellular domain fusion protein

<400>  198
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctgaaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacgacat      420

cgacgtcagg gcaaacactg gacatcgacc cagagaaagg ctgatttcca acatcctgca      480

ggggctgtgg ggccagagcc cacagacaga ggcctgcagt ggaggtccag cccagctgcc      540

gatgcccagg aagaaaacct ctatgctgcc gtgaagcaca cacagcctga ggatggggtg      600

gagatggaca ctcggagccc acacgatgaa gacccccagg cagtgacgta tgccgaggtg      660

aaacactcca gacctaggag agaaatggcc tctcctcctt ccccactgtc tggggaattc      720

ctggacacaa aggacagaca ggcggaagag gacaggcaga tggacactga ggctgctgca      780

tctgaagccc cccaggatgt gacctacgcc cagctgcaca gcttgaccct cagacgggag      840

gcaactgagc ctcctccatc ccaggaaggg ccctctccag ctgtgcccag catctacgcc      900

actctggcca tccac                                                       915


<210>  199
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z and LIR1 intracellular domain fusion protein

<400>  199
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctggatgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttccgaca tcgacgtcag      180

ggcaaacact ggacatcgac ccagagaaag gctgatttcc aacatcctgc aggggctgtg      240

gggccagagc ccacagacag aggcctgcag tggaggtcca gcccagctgc cgatgcccag      300

gaagaaaacc tctatgctgc cgtgaagcac acacagcctg aggatggggt ggagatggac      360

actcggagcc cacacgatga agacccccag gcagtgacgt atgccgaggt gaaacactcc      420

agacctagga gagaaatggc ctctcctcct tccccactgt ctggggaatt cctggacaca      480

aaggacagac aggcggaaga ggacaggcag atggacactg aggctgctgc atctgaagcc      540

ccccaggatg tgacctacgc ccagctgcac agcttgaccc tcagacggga ggcaactgag      600

cctcctccat cccaggaagg gccctctcca gctgtgccca gcatctacgc cactctggcc      660

atccac                                                                 666


<210>  200
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3D LIR1 fusion protein

<400>  200
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact gatgtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaaggctgt ctggggctgc cgacacacaa      420

gctctgttga ggaatgacgt gacctacgcc cagctgcaca gcttgaccct cagacgggag      480

gcaactgagc ctcctccatc ccaggaaggg ccctctccag ctgtgcccag catctacgcc      540

actctgggag gaaactgggc tcggaacaag                                       570


<210>  201
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3E LIR1 fusion protein

<400>  201
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgga catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

cctgtgacac gaggagcggg tgctggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccacctgttc ccaacgtgac ctacgcccag ctgcacagct tgaccctcag acgggaggca      600

actgagcctc ctccatccca ggaagggccc tctccagctg tgcccagcat ctacgccact      660

ctgaatcagc gcagaatc                                                    678


<210>  202
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3G LIR1 fusion protein

<400>  202
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctgaaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgcc agtcgagagc ttcagacaag cagactctgt tgcccaatga cgtgacctac      480

gcccagctgc acagcttgac cctcagacgg gaggcaactg agcctcctcc atcccaggaa      540

gggccctctc cagctgtgcc cagcatctac gccactctgc aaggaaacca gttgaggagg      600

aat                                                                    603


<210>  203
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z LIR1 fusion protein

<400>  203
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctggatgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagac      180

gcccccgcgt accagcaggg ccagaacgtg acctacgccc agctgcacag cttgaccctc      240

agacgggagg caactgagcc tcctccatcc caggaagggc cctctccagc tgtgcccagc      300

atctacgcca ctctggacaa gcgtagaggc cgggaccctg agatgggggg aaagccgaga      360

aggaagaacc ctcaggaagt gacctacgcc cagctgcaca gcttgaccct cagacgggag      420

gcaactgagc ctcctccatc ccaggaaggg ccctctccag ctgtgcccag catctacgcc      480

actctgggga tgaaaggcga gcgccggagg ggcaaggggc acgatgtgac ctacgcccag      540

ctgcacagct tgaccctcag acgggaggca actgagcctc ctccatccca ggaagggccc      600

tctccagctg tgcccagcat ctacgccact ctgcacatgc aggccctgcc ccctcgc         657


<210>  204
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z LIR1 fusion protein with D15K mutation

<400>  204

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Lys Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu 
65                  70                  75                  80  


Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro 
                85                  90                  95      


Ala Val Pro Ser Ile Tyr Ala Thr Leu Asp Lys Arg Arg Gly Arg Asp 
            100                 105                 110         


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Val Thr 
        115                 120                 125             


Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro 
    130                 135                 140                 


Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala 
145                 150                 155                 160 


Thr Leu Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Val 
                165                 170                 175     


Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu 
            180                 185                 190         


Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr 
        195                 200                 205             


Ala Thr Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 


<210>  205
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G LIR1 fusion protein with E122K mutation

<400>  205

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Lys Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Val Thr Tyr 
145                 150                 155                 160 


Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro 
                165                 170                 175     


Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr 
            180                 185                 190         


Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        195                 200     


<210>  206
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha with R253D mutation

<400>  206

Met Glu Thr Leu Leu Gly Leu Leu Ile Leu Trp Leu Gln Leu Gln Trp 
1               5                   10                  15      


Val Ser Ser Lys Gln Glu Val Thr Gln Ile Pro Ala Ala Leu Ser Val 
            20                  25                  30          


Pro Glu Gly Glu Asn Leu Val Leu Asn Cys Ser Phe Thr Asp Ser Ala 
        35                  40                  45              


Ile Tyr Asn Leu Gln Trp Phe Arg Gln Asp Pro Gly Lys Gly Leu Thr 
    50                  55                  60                  


Ser Leu Leu Leu Ile Gln Ser Ser Gln Arg Glu Gln Thr Ser Gly Arg 
65                  70                  75                  80  


Leu Asn Ala Ser Leu Asp Lys Ser Ser Gly Arg Ser Thr Leu Tyr Ile 
                85                  90                  95      


Ala Ala Ser Gln Pro Gly Asp Ser Ala Thr Tyr Leu Cys Ala Val Arg 
            100                 105                 110         


Pro Leu Tyr Gly Gly Ser Tyr Ile Pro Thr Phe Gly Arg Gly Thr Ser 
        115                 120                 125             


Leu Ile Val His Pro Tyr Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln 
    130                 135                 140                 


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
145                 150                 155                 160 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
                165                 170                 175     


Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
            180                 185                 190         


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
        195                 200                 205             


Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro 
    210                 215                 220                 


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
225                 230                 235                 240 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Asp Ile Leu 
                245                 250                 255     


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
            260                 265                 270         


Ser Ser 
        


<210>  207
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta with K288D mutation

<400>  207

Met Ser Ile Gly Leu Leu Cys Cys Ala Ala Leu Ser Leu Leu Trp Ala 
1               5                   10                  15      


Gly Pro Val Asn Ala Gly Val Thr Gln Thr Pro Lys Phe Gln Val Leu 
            20                  25                  30          


Lys Thr Gly Gln Ser Met Thr Leu Gln Cys Ala Gln Asp Met Asn His 
        35                  40                  45              


Glu Tyr Met Ser Trp Tyr Arg Gln Asp Pro Gly Met Gly Leu Arg Leu 
    50                  55                  60                  


Ile His Tyr Ser Val Gly Ala Gly Ile Thr Asp Gln Gly Glu Val Pro 
65                  70                  75                  80  


Asn Gly Tyr Asn Val Ser Arg Ser Thr Thr Glu Asp Phe Pro Leu Arg 
                85                  90                  95      


Leu Leu Ser Ala Ala Pro Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser 
            100                 105                 110         


Ser Tyr Val Gly Asn Thr Gly Glu Leu Phe Phe Gly Glu Gly Ser Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Asp Ala 
        275                 280                 285             


Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val 
    290                 295                 300                 


Lys Arg Lys Asp Ser Arg Gly 
305                 310     


<210>  208
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z with D15R mutation

<400>  208

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Arg Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  209
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z with D15K mutation

<400>  209

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Lys Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  210
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z D15R disulfide mutant

<400>  210

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Cys Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Gly 
            20                  25                  30          


Tyr Leu Leu Arg Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  211
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3Z D15K disulfide mutant

<400>  211

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Cys Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Gly 
            20                  25                  30          


Tyr Leu Leu Lys Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
            100                 105                 110         


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
        115                 120                 125             


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
    130                 135                 140                 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
145                 150                 155                 160 


Pro Pro Arg 
            


<210>  212
<211>  172
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D with D137K mutation

<400>  212

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Lys Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys Ala 
                165                 170         


<210>  213
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3D with D137R mutation

<400>  213

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Arg Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  214
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E with D137R mutation

<400>  214

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Arg Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  215
<211>  207
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3E with D137K mutation

<400>  215

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Lys Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  216
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G with E122R mutation

<400>  216

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Arg Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  217
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3G with E122K mutation

<400>  217

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Lys Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  218
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z LIR1 fusion protein with D15K mutation

<400>  218
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctgaaagg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagac      180

gcccccgcgt accagcaggg ccagaacgtg acctacgcac agctccatag tcttactctt      240

agaagggaag ctactgagcc gccgcctagc caggagggcc cttccccagc ggtcccttct      300

atctatgcga ctttggacaa aagaaggggc cgagaccctg aaatgggagg taaaccgcgt      360

cgaaagaatc cccaagaagt aacatacgcg caattgcata gcttgacact caggcgcgag      420

gcaacggagc ctccccccag ccaagagggt ccgagtcctg ccgttccgag tatatatgcc      480

actctcggta tgaaaggaga aaggcgcagg ggcaaaggcc atgacgtgac gtatgcgcaa      540

ttgcacagtc tgacgttgag gcgggaagcg actgagccac caccatccca agaagggcca      600

tctccggcgg tgccgtccat atatgcaact cttcacatgc aagctctgcc ccctcgc         657


<210>  219
<211>  603
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3G LIR1 fusion protein with E122K mutation

<400>  219
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctaagatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgcc agtcgagagc ttcagacaag cagactctgt tgcccaatga cgtgacctac      480

gcccagctgc acagcttgac cctcagacgg gaggcaactg agcctcctcc atcccaggaa      540

gggccctctc cagctgtgcc cagcatctac gccactctgc aaggaaacca gttgaggagg      600

aat                                                                    603


<210>  220
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR alpha with R253D mutation

<400>  220
atggagacac tcttgggcct gcttatcctt tggctgcagc tgcaatgggt gagcagcaaa       60

caggaggtga cgcagattcc tgcagctctg agtgtcccag aaggagaaaa cttggttctg      120

aactgcagtt tcactgatag cgctatttac aacctccagt ggtttaggca ggaccctggg      180

aaaggactca catctctgtt gcttattcag tcaagtcaga gagagcaaac aagtggaaga      240

cttaatgcct cgctggataa atcatcagga cgtagtactt tatacattgc agcttctcag      300

cctggtgact cagccaccta cctctgtgct gtgaggcccc tctacggagg aagctacata      360

cctacatttg gaagaggaac cagccttatt gttcatccgt atatccagaa ccctgaccct      420

gccgtgtacc agctgagaga ctctaaatcc agtgacaagt ctgtctgcct attcaccgat      480

tttgattctc aaacaaatgt gtcacaaagt aaggattctg atgtgtatat cacagacaaa      540

tgtgtgctag acatgaggtc tatggacttc aagagcaaca gtgctgtggc ctggagcaac      600

aaatctgact ttgcatgtgc aaacgccttc aacaacagca ttattccaga agacaccttc      660

ttccccagcc cagaaagttc ctgtgatgtc aagctggtcg agaaaagctt tgaaacagat      720

acgaacctaa actttcaaaa cctgtcagtg attgggttcg atatcctcct cctgaaagtg      780

gccgggttta atctgctcat gacgctgcgg ctgtggtcca gc                         822


<210>  221
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR beta with K288D mutation

<400>  221
atgagcatcg gcctcctgtg ctgtgcagcc ttgtctctcc tgtgggcagg tccagtgaat       60

gctggtgtca ctcagacccc aaaattccag gtcctgaaga caggacagag catgacactg      120

cagtgtgccc aggatatgaa ccatgaatac atgtcctggt atcgacaaga cccaggcatg      180

gggctgaggc tgattcatta ctcagttggt gctggtatca ctgaccaagg agaagtcccc      240

aatggctaca atgtctccag atcaaccaca gaggatttcc cgctcaggct gctgtcggct      300

gctccctccc agacatctgt gtacttctgt gccagcagtt acgtcgggaa caccggggag      360

ctgttttttg gagaaggctc taggctgacc gtactggagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgc caccatcctc      840

tatgagatct tgctagggga cgccaccttg tatgccgtgc tggtcagtgc cctcgtgctg      900

atggccatgg tcaagagaaa ggattccaga ggc                                   933


<210>  222
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z with D15R mutation

<400>  222
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctgcgtgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagac      180

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      240

gaggagtacg atgttttgga caagcgtaga ggccgggacc ctgagatggg gggaaagccg      300

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      360

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      420

taccagggac tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      480

ccccctcgc                                                              489


<210>  223
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z with D15K mutation

<400>  223
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

gcacagagct ttggcctgct ggatcccaaa ctctgctacc tgctgaaagg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagac      180

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      240

gaggagtacg atgttttgga caagcgtaga ggccgggacc ctgagatggg gggaaagccg      300

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      360

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      420

taccagggac tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      480

ccccctcgc                                                              489


<210>  224
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z with D15R disulfide mutant

<400>  224
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

tgtcagagct ttggcctgct ggatcccaaa ctcggctacc tgctgcgtgg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagac      180

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      240

gaggagtacg atgttttgga caagcgtaga ggccgggacc ctgagatggg gggaaagccg      300

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      360

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      420

taccagggac tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      480

ccccctcgc                                                              489


<210>  225
<211>  489
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3Z with D15K disulfide mutant

<400>  225
atgaagtgga aggcgctttt caccgcggcc atcctgcagg cacagttgcc gattacagag       60

tgtcagagct ttggcctgct ggatcccaaa ctcggctacc tgctgaaagg aatcctcttc      120

atctatggtg tcattctcac tgccttgttc ctgagagtga agttcagcag gagcgcagac      180

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga      240

gaggagtacg atgttttgga caagcgtaga ggccgggacc ctgagatggg gggaaagccg      300

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag      360

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt      420

taccagggac tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg      480

ccccctcgc                                                              489


<210>  226
<211>  513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3D with D137K mutation

<400>  226
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact aaggtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaaggctgt ctggggctgc cgacacacaa      420

gctctgttga ggaatgacca ggtctatcag cccctccgag atcgagatga tgctcagtac      480

agccaccttg gaggaaactg ggctcggaac aag                                   513


<210>  227
<211>  513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3D with D137R mutation

<400>  227
atggaacata gcacgtttct ctctggcctg gtactggcta cccttctctc gcaagtgagc       60

cccttcaaga tacctataga ggaacttgag gacagagtgt ttgtgaattg caataccagc      120

atcacatggg tagagggaac ggtgggaaca ctgctctcag acattacaag actggacctg      180

ggaaaacgca tcctggaccc acgaggaata tataggtgta atgggacaga tatatacaag      240

gacaaagaat ctaccgtgca agttcattat cgaatgtgcc agagctgtgt ggagctggat      300

ccagccaccg tggctggcat cattgtcact agggtcattg ccactctgct ccttgctttg      360

ggagtcttct gctttgctgg acatgagact ggaaggctgt ctggggctgc cgacacacaa      420

gctctgttga ggaatgacca ggtctatcag cccctccgag atcgagatga tgctcagtac      480

agccaccttg gaggaaactg ggctcggaac aag                                   513


<210>  228
<211>  621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3E with D137R mutation

<400>  228
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgcg catctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

cctgtgacac gaggagcggg tgctggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccacctgttc ccaacccaga ctatgagccc atccggaaag gccagcggga cctgtattct      600

ggcctgaatc agcgcagaat c                                                621


<210>  229
<211>  624
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3E with D137K mutation

<400>  229
atgcagtcgg gcactcactg gagagttctg ggcctctgcc tcttatcagt tggcgtttgg       60

gggcaagatg gtaatgaaga aatgggtggt attacacaga caccatataa agtctccatc      120

tctggaacca cagtaatatt gacatgccct cagtatcctg gatctgaaat actatggcaa      180

cacaatgata aaaacatagg cggtgatgag gatgataaaa acataggcag tgatgaggat      240

cacctgtcac tgaaggaatt ttcagaattg gagcaaagtg gttattatgt ctgctacccc      300

agaggaagca aaccagaaga tgcgaacttt tatctctacc tgagggcaag agtgtgtgag      360

aactgcatgg agatggatgt gatgtcggtg gccacaattg tcatagtgaa gatctgcatc      420

actgggggct tgctgctgct ggtttactac tggagcaaga atagaaaggc caaggccaag      480

cctgtgacac gaggagcggg tgctggcggc aggcaaaggg gacaaaacaa ggagaggcca      540

ccacctgttc ccaacccaga ctatgagccc atccggaaag gccagcggga cctgtattct      600

ggcctgaatc agcgcagaat ctag                                             624


<210>  230
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3G with E122R mutation

<400>  230
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctagaatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgcc agtcgagagc ttcagacaag cagactctgt tgcccaatga ccagctctac      480

cagcccctca aggatcgaga agatgaccag tacagccacc ttcaaggaaa ccagttgagg      540

aggaat                                                                 546


<210>  231
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3G with E122K mutation

<400>  231
atggaacagg ggaagggcct ggctgtcctc atcctggcta tcattcttct tcaaggtact       60

ttggcccagt caatcaaagg aaaccacttg gttaaggtgt atgactatca agaagatggt      120

tcggtacttc tgacttgtga tgcagaagcc aaaaatatca catggtttaa agatgggaag      180

atgatcggct tcctaactga agataaaaaa aaatggaatc tgggaagtaa tgccaaggac      240

cctcgaggga tgtatcagtg taaaggatca cagaacaagt caaaaccact ccaagtgtat      300

tacagaatgt gtcagaactg cattgaacta aatgcagcca ccatatctgg ctttctcttt      360

gctaagatcg tcagcatttt cgtccttgct gttggggtct acttcattgc tggacaggat      420

ggagttcgcc agtcgagagc ttcagacaag cagactctgt tgcccaatga ccagctctac      480

cagcccctca aggatcgaga agatgaccag tacagccacc ttcaaggaaa ccagttgagg      540

aggaat                                                                 546


<210>  232
<211>  501
<212>  DNA
<213>  Homo sapiens

<400>  232
cgacatcgac gtcagggcaa acactggaca tcgacccaga gaaaggctga tttccaacat       60

cctgcagggg ctgtggggcc agagcccaca gacagaggcc tgcagtggag gtccagccca      120

gctgccgatg cccaggaaga aaacctctat gctgccgtga agcacacaca gcctgaggat      180

ggggtggaga tggacactcg gagcccacac gatgaagacc cccaggcagt gacgtatgcc      240

gaggtgaaac actccagacc taggagagaa atggcctctc ctccttcccc actgtctggg      300

gaattcctgg acacaaagga cagacaggcg gaagaggaca ggcagatgga cactgaggct      360

gctgcatctg aagcccccca ggatgtgacc tacgcccagc tgcacagctt gaccctcaga      420

cgggaggcaa ctgagcctcc tccatcccag gaagggccct ctccagctgt gcccagcatc      480

tacgccactc tggccatcca c                                                501


<210>  233
<211>  151
<212>  DNA
<213>  Homo sapiens

<400>  233
ctgtctgggg ctgccgacac acaagctctg ttgaggaatg acgtgaccta cgcccagctg       60

cacagcttga ccctcagacg ggaggcaact gagcctcctc catcccagga agggccctct      120

ccagctgtgc ccagcatcta cgccactctg g                                     151


<210>  234
<211>  108
<212>  DNA
<213>  Homo sapiens

<400>  234
gtgacctacg cccagctgca cagcttgacc ctcagacggg aggcaactga gcctcctcca       60

tcccaggaag ggccctctcc agctgtgccc agcatctacg ccactctg                   108


<210>  235
<211>  285
<212>  DNA
<213>  Homo sapiens

<400>  235
cgggccgcac gagggacaat aggagccagg cgcaccggcc agcccctgaa ggaggacccc       60

tcagccgtgc ctgtgttctc tgtggactat ggggagctgg atttccagtg gcgagagaag      120

accccggagc cccccgtgcc ctgtgtccct gagcagacgg agtatgccac cattgtcttt      180

cctagcggaa tgggcacctc atcccccgcc cgcaggggct cagctgacgg ccctcggagt      240

gcccagccac tgaggcctga ggatggacac tgctcttggc ccctc                      285


<210>  236
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  236
acagagagaa gggcagaagt gcccacagcc caccccagcc cctcacccag gccagccggc       60

cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc tgggcagcct ggtgctgcta      120

gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag ggacaatagg agccaggcgc      180

accggccagc ccctgaagga ggacccctca gccgtgcctg tgttctctgt ggactatggg      240

gagctggatt tccagtggcg agagaagacc ccggagcccc ccgtgccctg tgtccctgag      300

cagacggagt atgccaccat tgtctttcct agcggaatgg gcacctcatc ccccgcccgc      360

aggggctcag ctgacggccc tcggagtgcc cagccactga ggcctgagga tggacactgc      420

tcttggcccc tc                                                          432


<210>  237
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM pair


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  X
<222>  (4)..(4)
<223>  X can be L or I

<220>
<221>  X
<222>  (5)..(10)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (12)..(13)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (14)..(14)
<223>  X can be L or I

<400>  237

Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  


<210>  238
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM pair


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X can be L or I

<220>
<221>  misc_feature
<222>  (5)..(11)
<223>  X can be any amino acid

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  X can be any amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  X can be L or I

<400>  238

Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  15  


<210>  239
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM pair


<220>
<221>  X
<222>  (2)..(3)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (4)..(4)
<223>  X can be L or I

<220>
<221>  X
<222>  (5)..(12)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (14)..(15)
<223>  X can be any amino acid

<220>
<221>  X
<222>  (16)..(16)
<223>  X can be L or I

<400>  239

Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa 
1               5                   10                  15      


<210>  240
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  240

Gly Gly Gly Ser 
1               


