                         SEQUENCE LISTING

<110>  2seventy bio, Inc.
       Inhibrx, Inc.
       Jarjour, Jordan
       Pogson, Mark
       Leung, Wai-Hang
       Astrakhan, Alexander
       Jones, Kyle S.
       Crago, William
       Sanabria, Angelica
       Hollands, Andrew
       Gano, Jacob
       Ma, Milton
       Timmer, John C.
       Eckelman, Brendan P.
       Rascon, Lucas
 
<120>  AML TARGETED IMMUNOTHERAPIES

<130>  BLUE-133.PC

<150>  US 63/111,255
<151>  2020-11-09

<150>  US 63/112,023
<151>  2020-11-10

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  2
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser 
1               5                   10                  15      


Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro 
            20                  25                  30          


Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu 
        35                  40                  45              


Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe 
    50                  55                  60                  


His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
65                  70                  75                  80  


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
                85                  90                  95      


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
            100                 105                 110         


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
        115                 120                 125             


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
    130                 135                 140                 


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
145                 150                 155                 160 


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
                165                 170                 175     


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
            180                 185                 190         


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
        195                 200                 205             


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
    210                 215                 220                 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
225                 230                 235                 240 


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
                245                 250                 255     


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
            260                 265 


<210>  3
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized anti CD33 VHH domain

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro 
        115     


<210>  4
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized anti-CLL VHH domain

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Lys Pro 
        115                 120 


<210>  5
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - synthesized anti-CLL VHH domain

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Thr Asp Glu Trp Gly Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro 
        115     


<210>  6
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - Synthesized DARIC signalling component

<400>  6

Gly Ser Ile Leu Trp His Glu Met Trp His Glu Gly Leu Glu Glu Ala 
1               5                   10                  15      


Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys Gly Met Phe Glu Val 
            20                  25                  30          


Leu Glu Pro Leu His Ala Met Met Glu Arg Gly Pro Gln Thr Leu Lys 
        35                  40                  45              


Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp Leu Met Glu Ala Gln 
    50                  55                  60                  


Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn Val Lys Asp Leu Leu 
65                  70                  75                  80  


Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg Arg Ile Ser Lys Ala 
                85                  90                  95      


Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            100                 105                 110         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Met His Lys Arg 
        115                 120                 125             


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
    130                 135                 140                 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
145                 150                 155                 160 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
                165                 170                 175     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            180                 185                 190         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        195                 200                 205             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    210                 215                 220                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
225                 230                 235                 240 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                245                 250                 255     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            260                 265                 270         


His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser Gly 
        275                 280                 


<210>  7
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - fusion construct tandem DARIC binding component

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe 
145                 150                 155                 160 


Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala 
            180                 185                 190         


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr Ala 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
            260                 265                 270         


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
        275                 280                 285             


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
    290                 295                 300                 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
305                 310                 315                 320 


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
                325                 330                 335     


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
            340                 345                 350         


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
        355                 360                 365             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    370                 375                 380                 


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
385                 390                 395             


<210>  8
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - fusion construct tandem DARIC binding component

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    130                 135                 140                 


Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
145                 150                 155                 160 


Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn 
            180                 185                 190         


Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
            260                 265                 270         


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
        275                 280                 285             


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
    290                 295                 300                 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
305                 310                 315                 320 


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
                325                 330                 335     


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
            340                 345                 350         


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
        355                 360                 365             


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
    370                 375                 380                 


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
385                 390                 395             


<210>  9
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - fusion construct tandem DARIC binding component

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Leu Phe 
145                 150                 155                 160 


Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala 
            180                 185                 190         


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg Glu Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val 
                245                 250                 255     


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
            260                 265                 270         


Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe 
        275                 280                 285             


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
    290                 295                 300                 


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
305                 310                 315                 320 


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
                325                 330                 335     


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
            340                 345                 350         


Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu 
        355                 360                 365             


Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe 
    370                 375                 380                 


Cys Val Arg Cys Arg His Arg Arg Arg Gln 
385                 390                 


<210>  10
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - fusion construct tandem DARIC binding component

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Thr Asp Glu Trp Gly Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly 
145                 150                 155                 160 


Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                165                 170                 175     


Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser 
            180                 185                 190         


Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val 
                245                 250                 255     


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
            260                 265                 270         


Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe 
        275                 280                 285             


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
    290                 295                 300                 


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
305                 310                 315                 320 


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
                325                 330                 335     


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
            340                 345                 350         


Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu 
        355                 360                 365             


Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe 
    370                 375                 380                 


Cys Val Arg Cys Arg His Arg Arg Arg Gln 
385                 390                 


<210>  11
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CD33 VHH DARIC binding component construct

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        115                 120                 125             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    130                 135                 140                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
145                 150                 155                 160 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                165                 170                 175     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            180                 185                 190         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        195                 200                 205             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    210                 215                 220                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
225                 230                 235                 240 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                245                 250                 255     


Cys Arg His Arg Arg Arg Gln 
            260             


<210>  12
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CD33 VHH DARIC binding component construct

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        115                 120                 125             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    130                 135                 140                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
145                 150                 155                 160 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                165                 170                 175     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            180                 185                 190         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        195                 200                 205             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    210                 215                 220                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
225                 230                 235                 240 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                245                 250                 255     


Cys Arg His Arg Arg Arg Gln 
            260             


<210>  13
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CLL-1.1 VHH DARIC binding component construct

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Lys Pro Pro Arg Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
    130                 135                 140                 


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
145                 150                 155                 160 


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
                165                 170                 175     


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
            180                 185                 190         


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
        195                 200                 205             


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
    210                 215                 220                 


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu 
225                 230                 235                 240 


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
                245                 250                 255     


Ile Phe Phe Gly Thr Gly 
            260         


<210>  14
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CLL-1.1 VHH DARIC binding component construct

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln 
        115                 120                 125             


Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly 
    130                 135                 140                 


Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly 
                165                 170                 175     


Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser 
            180                 185                 190         


Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly 
        195                 200                 205             


Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe 
    210                 215                 220                 


Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val 
225                 230                 235                 240 


Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe 
                245                 250                 255     


Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            260                 265         


<210>  15
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CLL-1.2 VHH DARIC binding component construct

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Thr Asp Glu Trp Gly Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro Pro Arg Gly Gly Gly Gly Ser Gly Val Gln Val Glu 
        115                 120                 125             


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
    130                 135                 140                 


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp 
145                 150                 155                 160 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
                165                 170                 175     


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
            180                 185                 190         


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
        195                 200                 205             


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
    210                 215                 220                 


Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly 
225                 230                 235                 240 


Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Gly 
                245                 250                 255     


Thr Gly 
        


<210>  16
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CLL-1.2 VHH DARIC binding component construct

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr 
            20                  25                  30          


Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


His Thr Asp Glu Trp Gly Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        115                 120                 125             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    130                 135                 140                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
145                 150                 155                 160 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                165                 170                 175     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            180                 185                 190         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        195                 200                 205             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    210                 215                 220                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
225                 230                 235                 240 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                245                 250                 255     


Cys Arg His Arg Arg Arg Gln 
            260             


<210>  17
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CD33 VHH DARIC construct

<400>  17

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala 
    370                 375                 380                 


Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp 
385                 390                 395                 400 


Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp 
                405                 410                 415     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val 
        435                 440                 445             


Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
465                 470                 475                 480 


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
                485                 490                 495     


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
            500                 505                 510         


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
        515                 520                 525             


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
    530                 535                 540                 


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
545                 550                 555                 560 


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg 
                565                 570                 575     


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
            580                 585                 590         


Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605             


<210>  18
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - CLL-1.1 VHH DARIC construct

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
465                 470                 475                 480 


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
                485                 490                 495     


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
            500                 505                 510         


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
        515                 520                 525             


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
    530                 535                 540                 


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
545                 550                 555                 560 


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
                565                 570                 575     


Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
            580                 585                 590         


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
        595                 600                 605             


Arg Arg Arg Gln 
    610         


<210>  19
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - CLL-1.2 VHH DARIC construct

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
465                 470                 475                 480 


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
                485                 490                 495     


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
            500                 505                 510         


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
        515                 520                 525             


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
    530                 535                 540                 


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
545                 550                 555                 560 


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg 
                565                 570                 575     


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
            580                 585                 590         


Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605             


<210>  20
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC CD33-CLL-1.1 construct

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala 
    370                 375                 380                 


Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp 
385                 390                 395                 400 


Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp 
                405                 410                 415     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val 
        435                 440                 445             


Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr 
        515                 520                 525             


Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe 
    530                 535                 540                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser 
545                 550                 555                 560 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu 
                565                 570                 575     


Thr Lys Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val 
            580                 585                 590         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        595                 600                 605             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    610                 615                 620                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
625                 630                 635                 640 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                645                 650                 655     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            660                 665                 670         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        675                 680                 685             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    690                 695                 700                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
705                 710                 715                 720 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                725                 730                 735     


Cys Arg His Arg Arg Arg Gln 
            740             


<210>  21
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC  CLL-1.1-CD33 construct

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
                485                 490                 495     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            500                 505                 510         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        515                 520                 525             


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    530                 535                 540                 


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
545                 550                 555                 560 


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                565                 570                 575     


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            580                 585                 590         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        595                 600                 605             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    610                 615                 620                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
625                 630                 635                 640 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                645                 650                 655     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            660                 665                 670         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        675                 680                 685             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    690                 695                 700                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
705                 710                 715                 720 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                725                 730                 735     


Cys Arg His Arg Arg Arg Gln 
            740             


<210>  22
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC CD33-CLL-1.2  construct

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala 
    370                 375                 380                 


Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp 
385                 390                 395                 400 


Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp 
                405                 410                 415     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val 
        435                 440                 445             


Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr 
        515                 520                 525             


Asn Asn Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe 
    530                 535                 540                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser 
545                 550                 555                 560 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu 
                565                 570                 575     


Trp Gly Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
        595                 600                 605             


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
    610                 615                 620                 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
625                 630                 635                 640 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
                645                 650                 655     


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
            660                 665                 670         


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
        675                 680                 685             


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695                 700                 


Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
705                 710                 715                 720 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
                725                 730                 735     


Arg Arg Gln 
            


<210>  23
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC  CLL-1.2-CD33 construct

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly 
        515                 520                 525             


Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
545                 550                 555                 560 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu 
                565                 570                 575     


Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
        595                 600                 605             


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
    610                 615                 620                 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
625                 630                 635                 640 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
                645                 650                 655     


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
            660                 665                 670         


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
        675                 680                 685             


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695                 700                 


Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
705                 710                 715                 720 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
                725                 730                 735     


Arg Arg Gln 
            


<210>  24
<211>  910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - dual DARIC CD33-CLL-1.1 construct

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala 
    370                 375                 380                 


Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp 
385                 390                 395                 400 


Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp 
                405                 410                 415     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val 
        435                 440                 445             


Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Pro Arg Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
465                 470                 475                 480 


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
                485                 490                 495     


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
            500                 505                 510         


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
        515                 520                 525             


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
    530                 535                 540                 


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
545                 550                 555                 560 


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
                565                 570                 575     


Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
            580                 585                 590         


Phe Ile Gly Leu Gly Ile Phe Phe Gly Thr Gly Ala Thr Asn Phe Ser 
        595                 600                 605             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Met 
    610                 615                 620                 


Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly 
625                 630                 635                 640 


Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln 
                645                 650                 655     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe 
            660                 665                 670         


Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
        675                 680                 685             


Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala 
    690                 695                 700                 


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
705                 710                 715                 720 


Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
                725                 730                 735     


Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr Ala 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
        755                 760                 765             


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
    770                 775                 780                 


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
785                 790                 795                 800 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
                805                 810                 815     


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
            820                 825                 830         


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
        835                 840                 845             


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
    850                 855                 860                 


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
865                 870                 875                 880 


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
                885                 890                 895     


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            900                 905                 910 


<210>  25
<211>  910
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - dual DARIC CLL-1.1-CD33 construct

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Pro Arg Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser 
465                 470                 475                 480 


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
                485                 490                 495     


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
            500                 505                 510         


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
        515                 520                 525             


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
    530                 535                 540                 


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
545                 550                 555                 560 


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
                565                 570                 575     


Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala 
            580                 585                 590         


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Gly Thr Gly Ala 
        595                 600                 605             


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
    610                 615                 620                 


Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu 
625                 630                 635                 640 


Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
                645                 650                 655     


Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            660                 665                 670         


Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
        675                 680                 685             


Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn 
    690                 695                 700                 


Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala 
705                 710                 715                 720 


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
                725                 730                 735     


Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
        755                 760                 765             


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
    770                 775                 780                 


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
785                 790                 795                 800 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
                805                 810                 815     


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
            820                 825                 830         


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
        835                 840                 845             


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
    850                 855                 860                 


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
865                 870                 875                 880 


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
                885                 890                 895     


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            900                 905                 910 


<210>  26
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in lab - dual DARIC CD33-CLL-1.2 construct

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala 
    370                 375                 380                 


Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp 
385                 390                 395                 400 


Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp 
                405                 410                 415     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val 
        435                 440                 445             


Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Pro Arg Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
465                 470                 475                 480 


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
                485                 490                 495     


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
            500                 505                 510         


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
        515                 520                 525             


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
    530                 535                 540                 


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
545                 550                 555                 560 


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
                565                 570                 575     


Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
            580                 585                 590         


Phe Ile Gly Leu Gly Ile Phe Phe Gly Thr Gly Ala Thr Asn Phe Ser 
        595                 600                 605             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Met 
    610                 615                 620                 


Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly 
625                 630                 635                 640 


Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln 
                645                 650                 655     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Leu Phe 
            660                 665                 670         


Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg 
        675                 680                 685             


Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr Ala 
    690                 695                 700                 


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
705                 710                 715                 720 


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
                725                 730                 735     


Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg Glu Tyr Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val 
        755                 760                 765             


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
    770                 775                 780                 


Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe 
785                 790                 795                 800 


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
                805                 810                 815     


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
            820                 825                 830         


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
        835                 840                 845             


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
    850                 855                 860                 


Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu 
865                 870                 875                 880 


Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe 
                885                 890                 895     


Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            900                 905     


<210>  27
<211>  906
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - dual DARIC CLL-1.2-CD33 construct

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Pro Arg Gly 
    450                 455                 460                 


Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
465                 470                 475                 480 


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
                485                 490                 495     


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
            500                 505                 510         


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
        515                 520                 525             


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
    530                 535                 540                 


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
545                 550                 555                 560 


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
                565                 570                 575     


Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
            580                 585                 590         


Phe Ile Gly Leu Gly Ile Phe Phe Gly Thr Gly Ala Thr Asn Phe Ser 
        595                 600                 605             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Met 
    610                 615                 620                 


Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly 
625                 630                 635                 640 


Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln 
                645                 650                 655     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly 
            660                 665                 670         


Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        675                 680                 685             


Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser 
    690                 695                 700                 


Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val 
705                 710                 715                 720 


Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                725                 730                 735     


Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly 
            740                 745                 750         


Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val 
        755                 760                 765             


Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln 
    770                 775                 780                 


Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe 
785                 790                 795                 800 


Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys 
                805                 810                 815     


Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val 
            820                 825                 830         


Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala 
        835                 840                 845             


Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp 
    850                 855                 860                 


Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu 
865                 870                 875                 880 


Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe 
                885                 890                 895     


Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            900                 905     


<210>  28
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly 
        435                 440                 445             


Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
465                 470                 475                 480 


Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg 
                485                 490                 495     


Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser 
        515                 520                 525             


Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr 
    530                 535                 540                 


Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe 
                565                 570                 575     


Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
            580                 585                 590         


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
        595                 600                 605             


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
    610                 615                 620                 


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
625                 630                 635                 640 


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
                645                 650                 655     


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
            660                 665                 670         


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
        675                 680                 685             


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
    690                 695                 700                 


Glu Gly Gly Ser Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
705                 710                 715                 720 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
                725                 730                 735     


Arg Arg Arg Gln 
            740 


<210>  29
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu 
                325                 330                 335     


Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly 
        515                 520                 525             


Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
545                 550                 555                 560 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu 
                565                 570                 575     


Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
        595                 600                 605             


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
    610                 615                 620                 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
625                 630                 635                 640 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
                645                 650                 655     


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
            660                 665                 670         


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
        675                 680                 685             


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695                 700                 


Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
705                 710                 715                 720 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
                725                 730                 735     


Arg Arg Gln 
            


<210>  30
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu 
                325                 330                 335     


Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly 
        515                 520                 525             


Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
545                 550                 555                 560 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu 
                565                 570                 575     


Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
        595                 600                 605             


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
    610                 615                 620                 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
625                 630                 635                 640 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
                645                 650                 655     


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
            660                 665                 670         


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
        675                 680                 685             


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695                 700                 


Gly Gly Ser Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
705                 710                 715                 720 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
                725                 730                 735     


Arg Arg Gln 
            


<210>  31
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys 
        435                 440                 445             


Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
    450                 455                 460                 


Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly 
                485                 490                 495     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp 
            500                 505                 510         


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        515                 520                 525             


Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala 
    530                 535                 540                 


Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
545                 550                 555                 560 


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                565                 570                 575     


Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu 
            580                 585                 590         


Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr 
        595                 600                 605             


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
    610                 615                 620                 


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
625                 630                 635                 640 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
                645                 650                 655     


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
            660                 665                 670         


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
        675                 680                 685             


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
    690                 695                 700                 


Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly 
705                 710                 715                 720 


Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val 
                725                 730                 735     


Arg Cys Arg His Arg Arg Arg Gln 
            740                 


<210>  32
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly 
        435                 440                 445             


Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
465                 470                 475                 480 


Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg 
                485                 490                 495     


Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser 
        515                 520                 525             


Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr 
    530                 535                 540                 


Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe 
                565                 570                 575     


Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
            580                 585                 590         


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
        595                 600                 605             


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
    610                 615                 620                 


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
625                 630                 635                 640 


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
                645                 650                 655     


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
            660                 665                 670         


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
        675                 680                 685             


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
    690                 695                 700                 


Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
705                 710                 715                 720 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
                725                 730                 735     


Arg Arg Arg Gln 
            740 


<210>  33
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly 
        435                 440                 445             


Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
465                 470                 475                 480 


Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg 
                485                 490                 495     


Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser 
        515                 520                 525             


Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr 
    530                 535                 540                 


Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe 
                565                 570                 575     


Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
            580                 585                 590         


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
        595                 600                 605             


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
    610                 615                 620                 


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
625                 630                 635                 640 


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
                645                 650                 655     


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
            660                 665                 670         


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
        675                 680                 685             


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
    690                 695                 700                 


Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
705                 710                 715                 720 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
                725                 730                 735     


Arg Arg Arg Gln 
            740 


<210>  34
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  34

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
465                 470                 475                 480 


Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg 
                485                 490                 495     


Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
            500                 505                 510         


Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr 
        515                 520                 525             


Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys 
    530                 535                 540                 


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
545                 550                 555                 560 


Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp 
                565                 570                 575     


Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
        595                 600                 605             


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
    610                 615                 620                 


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
625                 630                 635                 640 


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
                645                 650                 655     


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
            660                 665                 670         


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
        675                 680                 685             


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu 
    690                 695                 700                 


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
705                 710                 715                 720 


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                725                 730             


<210>  35
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
465                 470                 475                 480 


Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                485                 490                 495     


Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg 
            500                 505                 510         


Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val 
        515                 520                 525             


Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser 
    530                 535                 540                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
545                 550                 555                 560 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp 
                565                 570                 575     


Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
        595                 600                 605             


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
    610                 615                 620                 


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
625                 630                 635                 640 


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
                645                 650                 655     


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
            660                 665                 670         


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
        675                 680                 685             


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
    690                 695                 700                 


Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
705                 710                 715                 720 


Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg 
                725                 730                 735     


Arg Gln 
        


<210>  36
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
                485                 490                 495     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            500                 505                 510         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        515                 520                 525             


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    530                 535                 540                 


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
545                 550                 555                 560 


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                565                 570                 575     


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            580                 585                 590         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        595                 600                 605             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    610                 615                 620                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
625                 630                 635                 640 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                645                 650                 655     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            660                 665                 670         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        675                 680                 685             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    690                 695                 700                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
705                 710                 715                 720 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                725                 730                 735     


Cys Arg His Arg Arg Arg Gln 
            740             


<210>  37
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu 
                485                 490                 495     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser 
            500                 505                 510         


Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
        515                 520                 525             


Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala 
    530                 535                 540                 


Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn 
545                 550                 555                 560 


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
                565                 570                 575     


Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly 
            580                 585                 590         


Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val 
        595                 600                 605             


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
    610                 615                 620                 


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
625                 630                 635                 640 


Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
                645                 650                 655     


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
            660                 665                 670         


Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
        675                 680                 685             


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
    690                 695                 700                 


Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile 
705                 710                 715                 720 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                725                 730                 735     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            740                 745             


<210>  38
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
465                 470                 475                 480 


Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                485                 490                 495     


Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
            500                 505                 510         


Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn 
        515                 520                 525             


Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala 
    530                 535                 540                 


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
545                 550                 555                 560 


Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala 
                565                 570                 575     


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        595                 600                 605             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    610                 615                 620                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
625                 630                 635                 640 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                645                 650                 655     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            660                 665                 670         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        675                 680                 685             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
    690                 695                 700                 


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
705                 710                 715                 720 


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                725                 730                 


<210>  39
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys 
        435                 440                 445             


Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
    450                 455                 460                 


Lys Pro Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
465                 470                 475                 480 


Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                485                 490                 495     


Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
            500                 505                 510         


Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn 
        515                 520                 525             


Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala 
    530                 535                 540                 


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
545                 550                 555                 560 


Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala 
                565                 570                 575     


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        595                 600                 605             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    610                 615                 620                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
625                 630                 635                 640 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                645                 650                 655     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            660                 665                 670         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        675                 680                 685             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
    690                 695                 700                 


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
705                 710                 715                 720 


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                725                 730                 


<210>  40
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - human CD8a TM plus MH sequence

<400>  40

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Met His 
            20                  


<210>  41
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - human CD8a TM plus LYC sequence

<400>  41

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  25  


<210>  42
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - human CD8a TM plus LYS sequence

<400>  42

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Leu Tyr Ser 
            20                  25  


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  43

Gly Gly Gly Gly Ser 
1               5   


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  44

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  45
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  45

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  46
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  46

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  47
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  47

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  48

Asp Gly Gly Gly Ser 
1               5   


<210>  49
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  49

Thr Gly Glu Lys Pro 
1               5   


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  50

Gly Gly Arg Arg 
1               


<210>  51
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  51

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  52
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  52

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  53

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  54

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  55

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  56

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  57
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  57

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  58

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  59

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  60

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  61
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  61

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  62

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  63
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  63

Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10                  


<210>  64
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  64

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  65
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  65

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  66
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  66

Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10              


<210>  67
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  67

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  68
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  68

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  69
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  69

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  70
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  70

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  71
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  71

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  72
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  72

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  73

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  74

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  75
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  75

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  76
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  76

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  77
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  77

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  78
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  78

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  79
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  79

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  80
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  80

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  81
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  81

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  82
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  82

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  83
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  83
gccrccatgg                                                              10


<210>  84
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  84

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp 
                165                 170                 175     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
            180                 185                 190         


Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala 
        195                 200                 205             


Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
    210                 215                 220                 


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr 
            260                 265                 270         


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
        275                 280                 285             


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
    290                 295                 300                 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
305                 310                 315                 320 


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
                325                 330                 335     


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
            340                 345                 350         


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
        355                 360                 365             


Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly 
    370                 375                 380                 


Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val 
385                 390                 395                 400 


Arg Cys Arg His Arg Arg Arg Gln 
                405             


<210>  85
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  85

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg 
                165                 170                 175     


Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr 
        195                 200                 205             


Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
        275                 280                 285             


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
    290                 295                 300                 


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
305                 310                 315                 320 


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
                325                 330                 335     


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
            340                 345                 350         


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
        355                 360                 365             


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu 
    370                 375                 380                 


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
385                 390                 395                 400 


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                405                 410             


<210>  86
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  86

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val 
        195                 200                 205             


Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
225                 230                 235                 240 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp 
                245                 250                 255     


Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
        275                 280                 285             


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
    290                 295                 300                 


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
305                 310                 315                 320 


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
                325                 330                 335     


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
            340                 345                 350         


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
        355                 360                 365             


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
    370                 375                 380                 


Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
385                 390                 395                 400 


Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg 
                405                 410                 415     


Arg 
    


<210>  87
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  87

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            180                 185                 190         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        195                 200                 205             


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    210                 215                 220                 


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
225                 230                 235                 240 


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                245                 250                 255     


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            260                 265                 270         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        275                 280                 285             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    290                 295                 300                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
305                 310                 315                 320 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                325                 330                 335     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            340                 345                 350         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        355                 360                 365             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    370                 375                 380                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
385                 390                 395                 400 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                405                 410                 415     


Cys Arg His Arg Arg Arg Gln 
            420             


<210>  88
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  88

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile 
                165                 170                 175     


Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu 
            180                 185                 190         


Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu 
        195                 200                 205             


Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu 
            260                 265                 270         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        275                 280                 285             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp 
    290                 295                 300                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
305                 310                 315                 320 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                325                 330                 335     


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            340                 345                 350         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        355                 360                 365             


Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly 
    370                 375                 380                 


Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys 
385                 390                 395                 400 


Val Arg Cys Arg His Arg Arg Arg Gln 
                405                 


