                         SEQUENCE LISTING

<110>  Navigo Proteins GmbH
 
<120>  Binding proteins for Complement Factor H (CFH)

<130>  NP52 WO

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209202

<400>  1

Asn Ala Ala Asp Leu Asp Glu Ala Gln Ile Ser Ala Ile Phe Glu Ile 
1               5                   10                  15      


Met Asp Leu Pro Asn Leu Thr Trp Gln Gln Gln Glu Trp Phe Ile Asp 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Lys Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  2
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209264

<400>  2

Ile Ala Ala Lys Phe Asp Arg Ile Gln Ser Ile Ala Asp Glu Val Ile 
1               5                   10                  15      


Leu Ile Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Arg Gln 
            20                  25                  30          


Ser Leu Ser Asp Asp Pro Ser Val Ser Glu Glu Val Leu Tyr Glu Ala 
        35                  40                  45              


Leu Tyr Leu Asn Tyr Ser Gln Ala Pro Lys 
    50                  55              


<210>  3
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209274

<400>  3

Ile Ala Ala Arg Phe Asp Lys Ala Gln Arg Ala Ala Glu Leu Glu Ile 
1               5                   10                  15      


Lys Ala Leu Pro Asn Leu Thr Tyr Glu Gln Arg Lys Ala Phe Arg Val 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  4
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209275

<400>  4

Ile Ala Ala Arg Phe Asp His Ala Gln Trp Ala Ala Glu Leu Glu Ile 
1               5                   10                  15      


Lys Glu Leu Pro Asn Leu Thr Tyr Glu Gln Arg Lys Ala Phe Arg Ile 
            20                  25                  30          


Ser Leu Tyr Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  5
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209447

<400>  5

Asn Ala Ala Glu Ala Asp Asp Ala Gln Val Ser Ala Ala Met Glu Ile 
1               5                   10                  15      


Ile Met Leu Pro Asn Leu Thr Leu Glu Gln Ala His Ser Phe Ile Glu 
            20                  25                  30          


Ser Leu Tyr Arg Asp Pro Ser Val Ser Lys Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  6
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209466

<400>  6

Asn Ala Ala Asp Lys Asp Phe Ala Gln Glu Ser Ala Glu Tyr Glu Ile 
1               5                   10                  15      


Leu Met Leu Pro Asn Leu Thr Leu Asp Gln Ala Tyr Ser Phe Ile Leu 
            20                  25                  30          


Ser Leu Lys Ser Asp Pro Ser Val Ser Lys Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
    50                  55              


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 208851

<400>  7

Ile Ala Ala Lys Phe Asp Glu Ala Gln Trp Ala Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Val His Leu Pro Asn Leu Thr Glu Glu Gln Arg Glu Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Trp Asp Asp Pro Gly Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Ala Gln Arg Asn His Phe Ile Gln Arg Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Val Val Leu Gly Gln Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 208854

<400>  8

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Lys Ala Phe Tyr Trp Ile 
1               5                   10                  15      


Leu His Leu Arg Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Val Ser Thr Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Leu Lys Leu Asn Gln Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Trp Ala Ala Phe Tyr Glu Ile Val His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Glu Ala Phe Ile Gln Ser Leu Trp Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  9
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209354

<400>  9

Ile Ala Ala Lys Phe Asp Glu Ala Gln Trp Ala Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Val His Leu Pro Asn Leu Thr Glu Glu Gln Arg Glu Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Trp Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu His Gln Arg Asn His Phe Ile Gln Lys Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Gln Val Leu Gly His Ala Gln Arg Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209372

<400>  10

Ile Ala Ala Lys Phe Asp Glu Ala Gln Trp Ala Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Val His Leu Pro Asn Leu Thr Glu Glu Gln Arg Glu Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Trp Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Gln Gln Arg Asn Tyr Phe Ile Gln Arg Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Ala Val Leu Gly His Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209429

<400>  11

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Arg Ala Phe Tyr Trp Ile 
1               5                   10                  15      


Leu His Leu Arg Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Val Ser Lys Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Tyr Lys Leu Asn Lys Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Thr Ala Ala Phe Trp Glu Ile Trp His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Val Ala Phe Ile His Ser Leu Gln Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209434

<400>  12

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Arg Ala Phe Tyr Trp Ile 
1               5                   10                  15      


Leu His Leu Arg Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Val Ser Lys Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Tyr Lys Leu Asn Val Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Val Ala Ala Phe Trp Glu Ile Trp His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Val Ala Phe Ile His Ser Leu Gln Asp Asp Gln 
                85                  90                  95      


Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209621

<400>  13

Ile Ala Ala Lys Phe Asp Glu Ala Gln Thr Ala Ala Phe Trp Glu Ile 
1               5                   10                  15      


Glu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Trp 
            20                  25                  30          


Ser Leu Ala Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Trp Gln Arg Asn Tyr Phe Ile Gln Lys Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Trp Val Leu Gly Gln Ala Gln Ile Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  14
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protien 209826

<400>  14

Ile Ala Ala Lys Phe Asp Glu Ala Gln Glu Ala Ala Phe Trp Glu Ile 
1               5                   10                  15      


Gln His Leu Pro Asn Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Trp 
            20                  25                  30          


Ser Leu Ala Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Tyr Gln Arg Asn Leu Phe Ile Gln Arg Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Trp Val Leu Gly Gln Ala Gln Ile Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209827

<400>  15

Ile Ala Ala Lys Phe Asp Glu Ala Gln Glu Ala Ala Phe Trp Glu Ile 
1               5                   10                  15      


Gln His Leu Pro Asn Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Trp 
            20                  25                  30          


Ser Leu Ala Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Trp Gln Arg Asn Tyr Phe Ile Gln Lys Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Trp Val Leu Gly Gln Ala Gln Ile Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  16
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209831

<400>  16

Ile Ala Ala Lys Phe Asp Glu Ala Gln Trp Ala Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Val His Leu Pro Asn Leu Thr Glu Glu Gln Arg Glu Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Trp Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Arg Gln Arg Asn Trp Phe Ile Gln Arg Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Trp Val Leu Gly Arg Ala Gln Arg Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  17
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209833

<400>  17

Ile Ala Ala Lys Phe Asp Glu Ala Gln Glu Ala Ala Phe Trp Glu Ile 
1               5                   10                  15      


Gln His Leu Pro Asn Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Trp 
            20                  25                  30          


Ser Leu Ala Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu His Gln Arg Asn Leu Phe Ile Gln Arg Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Trp Val Leu Gly Gln Ala Gln Ile Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209835

<400>  18

Ile Ala Ala Lys Phe Asp Glu Ala Gln Trp Ala Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Val His Leu Pro Asn Leu Thr Glu Glu Gln Arg Glu Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Trp Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Arg Gln Arg Asn Trp Phe Ile Gln Gln Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Thr Val Leu Gly Arg Ala Gln Arg Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protien 209860

<400>  19

Ile Ala Ala Lys Phe Asp Glu Ala Gln Trp Ala Ala Phe Glu Glu Ile 
1               5                   10                  15      


Ala His Leu Pro Asn Leu Thr Glu Glu Gln Arg Glu Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Trp Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Arg Gln Arg Asn Trp Phe Ile Gln Arg Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Trp Val Leu Gly Arg Ala Gln Arg Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209864

<400>  20

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Leu Gln Arg Asn His Phe Ile Gln 
            20                  25                  30          


Thr Leu Arg Asp Asp Pro Ser Val Ser Leu Trp Val Leu Gly Leu Ala 
        35                  40                  45              


Gln Leu Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Gln His Ala Phe Tyr Thr Ile Leu His Leu Glu Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg Asn Ala Phe Ile Gln Ser Leu Arg Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Glu Val Leu Gly Glu Ala Ile Lys Leu Asn Ile Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209920

<400>  21

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Glu Ala Phe Tyr Trp Ile 
1               5                   10                  15      


Leu His Leu Glu Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Ile Gln 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Val Ser Glu Glu Val Leu Gly Glu Ala 
        35                  40                  45              


Leu Lys Leu Asn Val Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp 
    50                  55                  60                  


Glu Ala Gln Tyr Ala Ala Phe Trp Glu Ile Gln His Leu Pro Asn Leu 
65                  70                  75                  80  


Thr Glu Glu Gln Arg His Ala Phe Ile Trp Ser Leu Leu Asp Asp Pro 
                85                  90                  95      


Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser 
            100                 105                 110         


Gln Ala Pro Lys 
        115     


<210>  22
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 209921

<400>  22

Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Glu Trp Ala Phe Tyr His 
1               5                   10                  15      


Ile Leu His Leu Tyr Asn Leu Thr Glu Glu Gln Arg Asn Ala Phe Ile 
            20                  25                  30          


Gln Ser Leu Arg Asp Asp Pro Ser Val Ser Gln Glu Val Leu Gly Glu 
        35                  40                  45              


Ala Trp Lys Leu Asn Gln Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe 
    50                  55                  60                  


Asp Glu Ala Gln Tyr Ala Ala Phe Trp Glu Ile Trp His Leu Pro Asn 
65                  70                  75                  80  


Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Leu Ser Leu His Asp Asp 
                85                  90                  95      


Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp 
            100                 105                 110         


Ser Gln Ala Pro Lys 
        115         


<210>  23
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 213108 (SEQ13/209621variant del2N)

<400>  23

Ala Lys Phe Asp Glu Ala Gln Thr Ala Ala Phe Trp Glu Ile Glu His 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Trp Ser Leu 
            20                  25                  30          


Ala Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
    50                  55                  60                  


Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
65                  70                  75                  80  


Trp Gln Arg Asn Tyr Phe Ile Gln Lys Leu Arg Asp Asp Pro Ser Val 
                85                  90                  95      


Ser Leu Trp Val Leu Gly Gln Ala Gln Ile Leu Asn Asp Ser Gln Ala 
            100                 105                 110         


Pro Lys 
        


<210>  24
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protein 213109 (209621 delN dimer)

<400>  24

Ala Lys Phe Asp Glu Ala Gln Thr Ala Ala Phe Trp Glu Ile Glu His 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Trp Ser Leu 
            20                  25                  30          


Ala Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
    50                  55                  60                  


Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
65                  70                  75                  80  


Trp Gln Arg Asn Tyr Phe Ile Gln Lys Leu Arg Asp Asp Pro Ser Val 
                85                  90                  95      


Ser Leu Trp Val Leu Gly Gln Ala Gln Ile Leu Asn Asp Ser Gln Ala 
            100                 105                 110         


Pro Lys Gln Ala Pro Lys Val Asp Ala Lys Phe Asp Gln Ala Pro Lys 
        115                 120                 125             


Val Asp Ala Lys Phe Asp Ile Ala Ala Lys Phe Asp Glu Ala Gln Thr 
    130                 135                 140                 


Ala Ala Phe Trp Glu Ile Glu His Leu Pro Asn Leu Thr Glu Glu Gln 
145                 150                 155                 160 


Arg Trp Ala Phe Ile Trp Ser Leu Ala Asp Asp Pro Ser Val Ser Leu 
                165                 170                 175     


Glu Val Leu Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys 
            180                 185                 190         


Ile Ala Ala Lys Phe Asp Glu Ala Gln Gln Ala Ala Phe Tyr Glu Ile 
        195                 200                 205             


Leu His Leu Pro Asn Leu Thr Glu Trp Gln Arg Asn Tyr Phe Ile Gln 
    210                 215                 220                 


Lys Leu Arg Asp Asp Pro Ser Val Ser Leu Trp Val Leu Gly Gln Ala 
225                 230                 235                 240 


Gln Ile Leu Asn Asp Ser Gln Ala Pro Lys 
                245                 250 


<210>  25
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CFH binding protien 213110 (209621 delN fusion with PAdelFc 
       trimer)

<400>  25

Ala Lys Phe Asp Glu Ala Gln Thr Ala Ala Phe Trp Glu Ile Glu His 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Trp Ala Phe Ile Trp Ser Leu 
            20                  25                  30          


Ala Asp Asp Pro Ser Val Ser Leu Glu Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ile Ala Ala Lys Phe Asp Glu Ala 
    50                  55                  60                  


Gln Gln Ala Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr Glu 
65                  70                  75                  80  


Trp Gln Arg Asn Tyr Phe Ile Gln Lys Leu Arg Asp Asp Pro Ser Val 
                85                  90                  95      


Ser Leu Trp Val Leu Gly Gln Ala Gln Ile Leu Asn Asp Ser Gln Ala 
            100                 105                 110         


Pro Lys Ile Ala Ala Gln His Asp Lys Ile Gln Gln Ala Ala Asp Lys 
        115                 120                 125             


Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Lys Phe 
    130                 135                 140                 


Arg Gln Ser Leu Arg Asp Asp Pro Ser Val Ser Ala Glu Ile Leu Ala 
145                 150                 155                 160 


Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ile Ala Ala Gln 
                165                 170                 175     


His Asp Lys Ile Gln Gln Ala Ala Asp Lys Glu Ile Leu His Leu Pro 
            180                 185                 190         


Asn Leu Thr Glu Glu Gln Arg Asn Lys Phe Arg Gln Ser Leu Arg Asp 
        195                 200                 205             


Asp Pro Ser Val Ser Ala Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn 
    210                 215                 220                 


Asp Ala Gln Ala Pro Lys Ile Ala Ala Gln His Asp Lys Ile Gln Gln 
225                 230                 235                 240 


Ala Ala Asp Lys Glu Ile Leu His Leu Pro Asn Leu Thr Glu Glu Gln 
                245                 250                 255     


Arg Asn Lys Phe Arg Gln Ser Leu Arg Asp Asp Pro Ser Val Ser Ala 
            260                 265                 270         


Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
        275                 280                 285             


<210>  26
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAdelFc (non Ig binding protein)

<400>  26

Ile Ala Ala Gln His Asp Lys Ile Gln Gln Ala Ala Asp Lys Glu Ile 
1               5                   10                  15      


Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Lys Phe Arg Gln 
            20                  25                  30          


Ser Leu Arg Asp Asp Pro Ser Val Ser Ala Glu Ile Leu Ala Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys 
    50                  55              


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coupling and Streptag

<400>  27

Cys Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10      


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  streptag

<400>  28

Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
1               5                   10  


