                         SEQUENCE LISTING

<110>  VersaPeutics, Inc.
       Hauser, David  N.
       Kampert, Taylor   L.
       Sun, Miao
 
<120>  ANTIBODY VARIANTS AGAINST WNT RECEPTOR RYK

<130>  4894-3000200

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_L2 of an anti-Ryk antibody or antibody derivative

<400>  1

Arg Ala Asn Arg Leu Val Glu 
1               5           


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_H2 of an anti-Ryk antibody or antibody derivative

<400>  2

Ser Thr Gly Gly Gly Gly Thr Tyr 
1               5               


<210>  3
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_H3_1 of an anti-Ryk antibody or antibody derivative

<400>  3

His Gly Asp Ser Gly Asp Tyr 
1               5           


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_H3_2 of an anti-Ryk antibody or antibody derivative

<400>  4

His Gly Asp Gln Gly Asp Tyr 
1               5           


<210>  5
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_L1 of an anti-Ryk antibody or antibody derivative

<400>  5

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_L3 of an anti-Ryk antibody or antibody derivative

<400>  6

Leu Gln Tyr Asp Glu Phe Pro Leu Thr 
1               5                   


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_H1 of an anti-Ryk antibody or antibody derivative

<400>  7

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR_H3_3 of an anti-Ryk antibody or antibody derivative

<400>  8

His Gly Asp Asn Gly Asp Tyr 
1               5           


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VL, a light chain variable region of an anti-Ryk antibody 
       or antibody derivative

<400>  9

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Ile Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VH, a heavy chain variable region of an anti-Ryk antibody 
       or antibody derivative

<400>  10

Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Gly Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Gly Asp Asn Gly Asp Tyr Trp Gly His Gly Ser Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VL_1, a light chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Ile Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VL_2, a light chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Ile Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VL_3, a light chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Ala Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Ile Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VH_1, a heavy chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Gly Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Gly Asp Asn Gly Asp Tyr Trp Gly His Gly Ser Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VH_2, a heavy chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Asn Gly Gly Gly Gly Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Gly Asp Asn Gly Asp Tyr Trp Gly Gln Gly Ser Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  16
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VH_3, a heavy chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Thr Gly Gly Gly Gly Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Gly Asp Ser Gly Asp Tyr Trp Gly His Gly Ser Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  17
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VH_4, a heavy chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Thr Gly Gly Gly Gly Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Gly Asp Gln Gly Asp Tyr Trp Gly His Gly Ser Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ab5.5_VH_5, a heavy chain variable region of an anti-Ryk antibody
       or antibody derivative

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ala 
        35                  40                  45              


Ala Tyr Ile Ser Thr Gly Gly Gly Gly Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg His Gly Asp Asn Gly Asp Tyr Trp Gly His Gly Ser Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  19
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(8)
<223>  Homo sapiens Ryk(211-218)

<400>  19

Ser Arg Thr Ile Tyr Asp Pro Val 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ryk artificial peptide 1

<400>  20

Ala Arg Thr Ile Tyr Asp Pro Val 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ryk artificial peptide 2

<400>  21

Pro Arg Thr Ile Tyr Asp Pro Val 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ryk artificial peptide 3

<400>  22

Ser Arg Thr Leu Tyr Asp Pro Val 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ryk artificial peptide 4


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is a natural amino acid that is not T

<400>  23

Ser Arg Xaa Ile Tyr Asp Pro Val 
1               5               


<210>  24
<211>  594
<212>  PRT
<213>  Mus musculus


<220>
<221>  PEPTIDE
<222>  (1)..(594)
<223>  Mus musculus Ryk

<400>  24

Met Arg Ala Gly Arg Gly Gly Val Pro Gly Ser Gly Gly Leu Arg Ala 
1               5                   10                  15      


Pro Pro Pro Pro Leu Leu Leu Leu Leu Leu Ala Met Leu Pro Ala Ala 
            20                  25                  30          


Ala Pro Arg Ser Pro Ala Leu Ala Ala Ala Pro Ala Gly Pro Ser Val 
        35                  40                  45              


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Leu Gly Leu Asp 
    50                  55                  60                  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
65                  70                  75                  80  


Ser Phe Asn Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
                85                  90                  95      


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
            100                 105                 110         


Asn Phe Val Ala Met Gly Met Pro Gln Val Asn Ile Ser Ala Gln Gly 
        115                 120                 125             


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
    130                 135                 140                 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
145                 150                 155                 160 


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
                165                 170                 175     


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
            180                 185                 190         


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
        195                 200                 205             


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
    210                 215                 220                 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
225                 230                 235                 240 


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
                245                 250                 255     


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
            260                 265                 270         


Pro Asn Asn Ala Thr Pro Ile Thr Ser Ser Ser Gly Tyr Pro Thr Leu 
        275                 280                 285             


Arg Ile Glu Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys 
    290                 295                 300                 


Ala Lys Val Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys 
305                 310                 315                 320 


Asp Val Leu Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu 
                325                 330                 335     


Val Asp Glu Lys Asp Pro Asn Lys Glu Lys Gln Thr Phe Val Lys Thr 
            340                 345                 350         


Val Lys Asp Gln Ala Ser Glu Val Gln Val Thr Met Met Leu Thr Glu 
        355                 360                 365             


Ser Cys Lys Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr 
    370                 375                 380                 


His Val Cys Ile Glu Glu Gly Glu Lys Pro Met Val Val Leu Pro Tyr 
385                 390                 395                 400 


Met Asn Trp Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val 
                405                 410                 415     


Glu Ala Asn Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met 
            420                 425                 430         


Ala Ile Gln Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val 
        435                 440                 445             


Ile His Arg Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu 
    450                 455                 460                 


Gln Val Lys Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met 
465                 470                 475                 480 


Asp Tyr His Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met 
                485                 490                 495     


Ala Leu Glu Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val 
            500                 505                 510         


Trp Ala Phe Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr 
        515                 520                 525             


Pro Tyr Val Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp 
    530                 535                 540                 


Gly Tyr Arg Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala 
545                 550                 555                 560 


Val Met Ala Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe 
                565                 570                 575     


Gln Gln Leu Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala 
            580                 585                 590         


Tyr Val 
        


<210>  25
<211>  607
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(607)
<223>  Homo sapiens Ryk

<400>  25

Met Arg Gly Ala Ala Arg Leu Gly Arg Pro Gly Arg Ser Cys Leu Pro 
1               5                   10                  15      


Gly Ala Arg Gly Leu Arg Ala Pro Pro Pro Pro Pro Leu Leu Leu Leu 
            20                  25                  30          


Leu Ala Leu Leu Pro Leu Leu Pro Ala Pro Gly Ala Ala Ala Ala Pro 
        35                  40                  45              


Ala Pro Arg Pro Pro Glu Leu Gln Ser Ala Ser Ala Gly Pro Ser Val 
    50                  55                  60                  


Ser Leu Tyr Leu Ser Glu Asp Glu Val Arg Arg Leu Ile Gly Leu Asp 
65                  70                  75                  80  


Ala Glu Leu Tyr Tyr Val Arg Asn Asp Leu Ile Ser His Tyr Ala Leu 
                85                  90                  95      


Ser Phe Ser Leu Leu Val Pro Ser Glu Thr Asn Phe Leu His Phe Thr 
            100                 105                 110         


Trp His Ala Lys Ser Lys Val Glu Tyr Lys Leu Gly Phe Gln Val Asp 
        115                 120                 125             


Asn Val Leu Ala Met Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly 
    130                 135                 140                 


Glu Val Pro Arg Thr Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr 
145                 150                 155                 160 


Gly Lys Val Asp Ser Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr 
                165                 170                 175     


Val Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
            180                 185                 190         


Met Cys Tyr Lys Lys Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys 
        195                 200                 205             


Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr 
    210                 215                 220                 


Ser Thr Arg Val Phe Tyr Ile Ser Val Gly Val Cys Cys Ala Val Ile 
225                 230                 235                 240 


Phe Leu Val Ala Ile Ile Leu Ala Val Leu His Leu His Ser Met Lys 
                245                 250                 255     


Arg Ile Glu Leu Asp Asp Ser Ile Ser Ala Ser Ser Ser Ser Gln Gly 
            260                 265                 270         


Leu Ser Gln Pro Ser Thr Gln Thr Thr Gln Tyr Leu Arg Ala Asp Thr 
        275                 280                 285             


Pro Asn Asn Ala Thr Pro Ile Thr Ser Tyr Pro Thr Leu Arg Ile Glu 
    290                 295                 300                 


Lys Asn Asp Leu Arg Ser Val Thr Leu Leu Glu Ala Lys Gly Lys Val 
305                 310                 315                 320 


Lys Asp Ile Ala Ile Ser Arg Glu Arg Ile Thr Leu Lys Asp Val Leu 
                325                 330                 335     


Gln Glu Gly Thr Phe Gly Arg Ile Phe His Gly Ile Leu Ile Asp Glu 
            340                 345                 350         


Lys Asp Pro Asn Lys Glu Lys Gln Ala Phe Val Lys Thr Val Lys Asp 
        355                 360                 365             


Gln Ala Ser Glu Ile Gln Val Thr Met Met Leu Thr Glu Ser Cys Lys 
    370                 375                 380                 


Leu Arg Gly Leu His His Arg Asn Leu Leu Pro Ile Thr His Val Cys 
385                 390                 395                 400 


Ile Glu Glu Gly Glu Lys Pro Met Val Ile Leu Pro Tyr Met Asn Trp 
                405                 410                 415     


Gly Asn Leu Lys Leu Phe Leu Arg Gln Cys Lys Leu Val Glu Ala Asn 
            420                 425                 430         


Asn Pro Gln Ala Ile Ser Gln Gln Asp Leu Val His Met Ala Ile Gln 
        435                 440                 445             


Ile Ala Cys Gly Met Ser Tyr Leu Ala Arg Arg Glu Val Ile His Lys 
    450                 455                 460                 


Asp Leu Ala Ala Arg Asn Cys Val Ile Asp Asp Thr Leu Gln Val Lys 
465                 470                 475                 480 


Ile Thr Asp Asn Ala Leu Ser Arg Asp Leu Phe Pro Met Asp Tyr His 
                485                 490                 495     


Cys Leu Gly Asp Asn Glu Asn Arg Pro Val Arg Trp Met Ala Leu Glu 
            500                 505                 510         


Ser Leu Val Asn Asn Glu Phe Ser Ser Ala Ser Asp Val Trp Ala Phe 
        515                 520                 525             


Gly Val Thr Leu Trp Glu Leu Met Thr Leu Gly Gln Thr Pro Tyr Val 
    530                 535                 540                 


Asp Ile Asp Pro Phe Glu Met Ala Ala Tyr Leu Lys Asp Gly Tyr Arg 
545                 550                 555                 560 


Ile Ala Gln Pro Ile Asn Cys Pro Asp Glu Leu Phe Ala Val Met Ala 
                565                 570                 575     


Cys Cys Trp Ala Leu Asp Pro Glu Glu Arg Pro Lys Phe Gln Gln Leu 
            580                 585                 590         


Val Gln Cys Leu Thr Glu Phe His Ala Ala Leu Gly Ala Tyr Val 
        595                 600                 605         


<210>  26
<211>  94
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(94)
<223>  Homo sapiens Ryk(134-227)

<400>  26

Asp Met Pro Gln Val Asn Ile Ser Val Gln Gly Glu Val Pro Arg Thr 
1               5                   10                  15      


Leu Ser Val Phe Arg Val Glu Leu Ser Cys Thr Gly Lys Val Asp Ser 
            20                  25                  30          


Glu Val Met Ile Leu Met Gln Leu Asn Leu Thr Val Asn Ser Ser Lys 
        35                  40                  45              


Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys Met Cys Tyr Lys Lys 
    50                  55                  60                  


Leu Glu Glu Val Lys Thr Ser Ala Leu Asp Lys Asn Thr Ser Arg Thr 
65                  70                  75                  80  


Ile Tyr Asp Pro Val His Ala Ala Pro Thr Thr Ser Thr Arg 
                85                  90                  


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neutral peptide linker

<400>  27

Gly Ser Gly Ser Gly Ser Gly 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  Homo sapiens Ryk(210-218)

<400>  28

Thr Ser Arg Thr Ile Tyr Asp Pro Val 
1               5                   


<210>  29
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(14)
<223>  Homo sapiens Ryk(179-192)

<400>  29

Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
1               5                   10                  


<210>  30
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(14)
<223>  Homo sapiens Ryk(184-197)

<400>  30

Thr Val Leu Asn Phe Lys Arg Arg Lys Met Cys Tyr Lys Lys 
1               5                   10                  


<210>  31
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(13)
<223>  Homo sapiens Ryk(190-202)

<400>  31

Arg Arg Lys Met Cys Tyr Lys Lys Leu Glu Glu Val Lys 
1               5                   10              


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Homo sapiens Ryk(206-220)

<400>  32

Leu Asp Lys Asn Thr Ser Arg Thr Ile Tyr Asp Pro Val His Ala 
1               5                   10                  15  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Neutral peptide linker

<400>  33

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly 
1               5                   10  


<210>  34
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(5)
<223>  Homo sapiens Ryk(206-210)

<400>  34

Leu Asp Lys Asn Thr 
1               5   


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Homo sapiens Ryk(178-192)

<400>  35

Asn Ser Ser Lys Asn Phe Thr Val Leu Asn Phe Lys Arg Arg Lys 
1               5                   10                  15  


<210>  36
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(13)
<223>  Homo sapiens Ryk(185-197)

<400>  36

Val Leu Asn Phe Lys Arg Arg Lys Met Cys Tyr Lys Lys 
1               5                   10              


