                         SEQUENCE LISTING

<110>  CITY OF HOPE
 
<120>  NUCLEIC ACIDS, PROTEINS, AND VACCINES OF SARS-COV-2

<130>  048440-776001WO

<140>  PCT/US2021/058929
<141>  2021-11-11

<150>  63/112,591
<151>  2020-11-11

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  7793
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  1
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcgtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1200

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1260

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1320

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1380

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1440

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1500

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1560

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1620

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1680

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1740

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     1800

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     1860

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     1920

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     1980

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2040

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2100

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2160

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2220

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2280

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2340

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2400

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2460

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2520

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2580

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2640

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2700

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     2760

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     2820

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     2880

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     2940

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3000

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3060

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3120

tgtgcatctt atcaaaccca aaccaactcc ccccgacgcg cccgctctgt tgcgtcacag     3180

agtattatag cctatacgat gtctttgggg gcggaaaact ccgtcgctta ctccaacaac     3240

agtatagcaa tccctacgaa ttttaccatc tccgtaacaa ctgaaatcct tcctgtgtca     3300

atgaccaaaa cttctgtcga ttgcacgatg tatatctgcg gagacagcac ggaatgtagt     3360

aacttgctcc tccagtacgg ctctttctgc acacagctca atcgggcgct gaccgggata     3420

gcggtggaac aagacaagaa cacccaggaa gtcttcgcgc aggtcaagca aatctacaag     3480

acccctccca ttaaagattt tggtggtttt aactttagcc aaatactgcc agatccgtcc     3540

aaaccctcca aacgatcctt catcgaggac ctccttttta acaaagttac cctcgccgac     3600

gccgggttca taaaacagta cggcgactgc ttgggtgaca tcgcagccag agacttgatt     3660

tgtgcgcaaa aattcaacgg ccttacggtc ctgcctccat tgctgaccga tgaaatgatt     3720

gcccagtata cctctgcttt gttggcaggg acaataactt ctgggtggac gtttggagca     3780

ggcgctgccc tgcagatccc ttttgccatg cagatggcat accggtttaa cgggatcggt     3840

gttactcaga acgtactcta tgagaatcaa aagctgatcg ccaaccaatt taatagcgcc     3900

atcggtaaaa tccaggatag tttgagcagc accgcttctg cacttgggaa gcttcaggat     3960

gttgtgaatc agaacgccca agcattgaat actctcgtca aacaattgag tagtaatttc     4020

ggagccatct catctgtgtt gaatgacata ctcagtcgcc tcgataaggt agaggctgag     4080

gtgcagatag accggcttat aactggtaga ttgcagagcc ttcagactta cgtgacgcaa     4140

cagcttatcc gagcagcaga aatcagggca tcagcaaatc ttgccgccac caaaatgtca     4200

gagtgcgtac tgggccaaag taaaagagtg gatttttgtg gaaaaggata ccacttgatg     4260

agctttcccc agtctgcccc gcacggtgtg gtcttcctgc acgtaaccta cgtgccggcg     4320

caagaaaaaa actttaccac cgctcccgcg atatgtcacg acggaaaggc gcattttccg     4380

cgagaaggcg tatttgtatc aaacggaaca cactggttcg ttacccagcg aaacttctac     4440

gagccacaga tcattactac ggataataca ttcgtctctg gtaattgcga tgtagtcata     4500

ggaatagtaa ataatacggt ttatgacccc ctccaacctg agcttgactc cttcaaagag     4560

gaacttgata aatactttaa gaatcatacc tctccggatg tcgatctcgg ggatatttct     4620

ggtatcaatg caagcgtcgt gaacatacag aaagaaatcg acagattgaa cgaagtcgcg     4680

aagaatctta acgaatctct gatagacttg caagaattgg gcaagtatga gcagtatata     4740

aaatggccat ggtacatttg gttgggattc atcgcaggat tgatcgccat tgttatggtt     4800

acaatcatgc tctgttgtat gaccagttgc tgtagctgct tgaagggctg ctgctcatgc     4860

ggttcttgtt gcggcggccg ctacccatac gacgtaccag attacgctta aagatctttt     4920

tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga cttctggcta     4980

ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg     5040

aaggacatat gggagggcaa atcatttaaa acatcagaat gagtatttgg tttagagttt     5100

ggcaacatat gcccattctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg     5160

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg     5220

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     5280

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     5340

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     5400

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     5460

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     5520

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     5580

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     5640

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     5700

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     5760

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     5820

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     5880

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     5940

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     6000

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     6060

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     6120

tgcctgactc gggggggggg ggcgctgagg tctgcctcgt gaagaaggtg ttgctgactc     6180

ataccaggcc tgaatcgccc catcatccag ccagaaagtg agggagccac ggttgatgag     6240

agctttgttg taggtggacc agttggtgat tttgaacttt tgctttgcca cggaacggtc     6300

tgcgttgtcg ggaagatgcg tgatctgatc cttcaactca gcaaaagttc gatttattca     6360

acaaagccgc cgtcccgtca agtcagcgta atgctctgcc agtgttacaa ccaattaacc     6420

aattctgatt agaaaaactc atcgagcatc aaatgaaact gcaatttatt catatcagga     6480

ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg     6540

cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg tccaacatca     6600

atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa atcaccatga     6660

gtgacgactg aatccggtga gaatggcaaa agcttatgca tttctttcca gacttgttca     6720

acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc gttattcatt     6780

cgtgattgcg cctgagcgag acgaaatacg cgatcgctgt taaaaggaca attacaaaca     6840

ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt ttcacctgaa     6900

tcaggatatt cttctaatac ctggaatgct gttttcccgg ggatcgcagt ggtgagtaac     6960

catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat aaattccgtc     7020

agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc tttgccatgt     7080

ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt cgcacctgat     7140

tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat gttggaattt     7200

aatcgcggcc tggagcaaga cgtttcccgt tgaatatggc tcataacacc ccttgtatta     7260

ctgtttatgt aagcagacag ttttattgtt catgatgata tatttttatc ttgtgcaatg     7320

taacatcaga gattttgaga cacaacgtgg ctttcccccc ccccccatta ttgaagcatt     7380

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     7440

ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt     7500

atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc     7560

ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg     7620

taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt     7680

cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca ccatatgcgg     7740

tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcagattggc tat            7793


<210>  2
<211>  1278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Val Asn Leu Thr Thr 
            20                  25                  30          


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        35                  40                  45              


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    50                  55                  60                  


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
65                  70                  75                  80  


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                85                  90                  95      


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            100                 105                 110         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        115                 120                 125             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    130                 135                 140                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
145                 150                 155                 160 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                165                 170                 175     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            180                 185                 190         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        195                 200                 205             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    210                 215                 220                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
225                 230                 235                 240 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                245                 250                 255     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            260                 265                 270         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        275                 280                 285             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    290                 295                 300                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
305                 310                 315                 320 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                325                 330                 335     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            340                 345                 350         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        355                 360                 365             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    370                 375                 380                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
385                 390                 395                 400 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                405                 410                 415     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            420                 425                 430         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        435                 440                 445             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    450                 455                 460                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
465                 470                 475                 480 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                485                 490                 495     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            500                 505                 510         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        515                 520                 525             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    530                 535                 540                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
545                 550                 555                 560 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                565                 570                 575     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            580                 585                 590         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        595                 600                 605             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    610                 615                 620                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
625                 630                 635                 640 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                645                 650                 655     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            660                 665                 670         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        675                 680                 685             


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
    690                 695                 700                 


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
705                 710                 715                 720 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
                725                 730                 735     


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
            740                 745                 750         


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
        755                 760                 765             


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
    770                 775                 780                 


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
785                 790                 795                 800 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
                805                 810                 815     


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
            820                 825                 830         


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
        835                 840                 845             


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
    850                 855                 860                 


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
865                 870                 875                 880 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
                885                 890                 895     


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
            900                 905                 910         


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
        915                 920                 925             


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
    930                 935                 940                 


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
945                 950                 955                 960 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
                965                 970                 975     


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
            980                 985                 990         


Leu Ser Arg Leu Asp Lys Val Glu  Ala Glu Val Gln Ile  Asp Arg Leu 
        995                 1000                 1005             


Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
    1010                 1015                 1020             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1025                 1030                 1035             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1040                 1045                 1050             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1055                 1060                 1065             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1070                 1075                 1080             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1085                 1090                 1095             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1100                 1105                 1110             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1115                 1120                 1125             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1130                 1135                 1140             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1145                 1150                 1155             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1160                 1165                 1170             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1175                 1180                 1185             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1190                 1195                 1200             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1205                 1210                 1215             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1220                 1225                 1230             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1235                 1240                 1245             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1250                 1255                 1260             


Ser Cys  Cys Gly Gly Arg Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    1265                 1270                 1275             


<210>  3
<211>  8033
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  3
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcaactt tgactgctgt cttggataca cagaccgtat tcttcatcct     1200

aaatttattg tgggcttcac acggcagctg gccaatgaag gctgtgacat caatgctatc     1260

atctttcaca caaagaaaaa gttgtctgtg tgcgcaaatc caaaacagac ttgggtgaaa     1320

tatattgtgc gtctcctcag taaaaaagtc aagaacatgg aattcaacga cgctcaggcg     1380

ccgaagagtc tcgaggtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1440

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1500

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1560

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1620

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1680

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1740

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1800

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1860

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1920

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1980

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     2040

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     2100

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     2160

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     2220

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2280

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2340

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2400

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2460

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2520

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2580

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2640

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2700

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2760

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2820

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2880

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2940

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     3000

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     3060

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     3120

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     3180

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3240

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3300

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3360

tgtgcatctt atcaaaccca aaccaactcc ccccgacgcg cccgctctgt tgcgtcacag     3420

agtattatag cctatacgat gtctttgggg gcggaaaact ccgtcgctta ctccaacaac     3480

agtatagcaa tccctacgaa ttttaccatc tccgtaacaa ctgaaatcct tcctgtgtca     3540

atgaccaaaa cttctgtcga ttgcacgatg tatatctgcg gagacagcac ggaatgtagt     3600

aacttgctcc tccagtacgg ctctttctgc acacagctca atcgggcgct gaccgggata     3660

gcggtggaac aagacaagaa cacccaggaa gtcttcgcgc aggtcaagca aatctacaag     3720

acccctccca ttaaagattt tggtggtttt aactttagcc aaatactgcc agatccgtcc     3780

aaaccctcca aacgatcctt catcgaggac ctccttttta acaaagttac cctcgccgac     3840

gccgggttca taaaacagta cggcgactgc ttgggtgaca tcgcagccag agacttgatt     3900

tgtgcgcaaa aattcaacgg ccttacggtc ctgcctccat tgctgaccga tgaaatgatt     3960

gcccagtata cctctgcttt gttggcaggg acaataactt ctgggtggac gtttggagca     4020

ggcgctgccc tgcagatccc ttttgccatg cagatggcat accggtttaa cgggatcggt     4080

gttactcaga acgtactcta tgagaatcaa aagctgatcg ccaaccaatt taatagcgcc     4140

atcggtaaaa tccaggatag tttgagcagc accgcttctg cacttgggaa gcttcaggat     4200

gttgtgaatc agaacgccca agcattgaat actctcgtca aacaattgag tagtaatttc     4260

ggagccatct catctgtgtt gaatgacata ctcagtcgcc tcgataaggt agaggctgag     4320

gtgcagatag accggcttat aactggtaga ttgcagagcc ttcagactta cgtgacgcaa     4380

cagcttatcc gagcagcaga aatcagggca tcagcaaatc ttgccgccac caaaatgtca     4440

gagtgcgtac tgggccaaag taaaagagtg gatttttgtg gaaaaggata ccacttgatg     4500

agctttcccc agtctgcccc gcacggtgtg gtcttcctgc acgtaaccta cgtgccggcg     4560

caagaaaaaa actttaccac cgctcccgcg atatgtcacg acggaaaggc gcattttccg     4620

cgagaaggcg tatttgtatc aaacggaaca cactggttcg ttacccagcg aaacttctac     4680

gagccacaga tcattactac ggataataca ttcgtctctg gtaattgcga tgtagtcata     4740

ggaatagtaa ataatacggt ttatgacccc ctccaacctg agcttgactc cttcaaagag     4800

gaacttgata aatactttaa gaatcatacc tctccggatg tcgatctcgg ggatatttct     4860

ggtatcaatg caagcgtcgt gaacatacag aaagaaatcg acagattgaa cgaagtcgcg     4920

aagaatctta acgaatctct gatagacttg caagaattgg gcaagtatga gcagtatata     4980

aaatggccat ggtacatttg gttgggattc atcgcaggat tgatcgccat tgttatggtt     5040

acaatcatgc tctgttgtat gaccagttgc tgtagctgct tgaagggctg ctgctcatgc     5100

ggttcttgtt gcggcggccg ctacccatac gacgtaccag attacgctta aagatctttt     5160

tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga cttctggcta     5220

ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctcactcgg     5280

aaggacatat gggagggcaa atcatttaaa acatcagaat gagtatttgg tttagagttt     5340

ggcaacatat gcccattctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg     5400

gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg     5460

ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa     5520

ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg     5580

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc     5640

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc     5700

ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc     5760

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg     5820

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc     5880

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga     5940

gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc     6000

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac     6060

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg     6120

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc     6180

acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa     6240

ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta     6300

ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt     6360

tgcctgactc gggggggggg ggcgctgagg tctgcctcgt gaagaaggtg ttgctgactc     6420

ataccaggcc tgaatcgccc catcatccag ccagaaagtg agggagccac ggttgatgag     6480

agctttgttg taggtggacc agttggtgat tttgaacttt tgctttgcca cggaacggtc     6540

tgcgttgtcg ggaagatgcg tgatctgatc cttcaactca gcaaaagttc gatttattca     6600

acaaagccgc cgtcccgtca agtcagcgta atgctctgcc agtgttacaa ccaattaacc     6660

aattctgatt agaaaaactc atcgagcatc aaatgaaact gcaatttatt catatcagga     6720

ttatcaatac catatttttg aaaaagccgt ttctgtaatg aaggagaaaa ctcaccgagg     6780

cagttccata ggatggcaag atcctggtat cggtctgcga ttccgactcg tccaacatca     6840

atacaaccta ttaatttccc ctcgtcaaaa ataaggttat caagtgagaa atcaccatga     6900

gtgacgactg aatccggtga gaatggcaaa agcttatgca tttctttcca gacttgttca     6960

acaggccagc cattacgctc gtcatcaaaa tcactcgcat caaccaaacc gttattcatt     7020

cgtgattgcg cctgagcgag acgaaatacg cgatcgctgt taaaaggaca attacaaaca     7080

ggaatcgaat gcaaccggcg caggaacact gccagcgcat caacaatatt ttcacctgaa     7140

tcaggatatt cttctaatac ctggaatgct gttttcccgg ggatcgcagt ggtgagtaac     7200

catgcatcat caggagtacg gataaaatgc ttgatggtcg gaagaggcat aaattccgtc     7260

agccagttta gtctgaccat ctcatctgta acatcattgg caacgctacc tttgccatgt     7320

ttcagaaaca actctggcgc atcgggcttc ccatacaatc gatagattgt cgcacctgat     7380

tgcccgacat tatcgcgagc ccatttatac ccatataaat cagcatccat gttggaattt     7440

aatcgcggcc tggagcaaga cgtttcccgt tgaatatggc tcataacacc ccttgtatta     7500

ctgtttatgt aagcagacag ttttattgtt catgatgata tatttttatc ttgtgcaatg     7560

taacatcaga gattttgaga cacaacgtgg ctttcccccc ccccccatta ttgaagcatt     7620

tatcagggtt attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa     7680

ataggggttc cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt     7740

atcatgacat taacctataa aaataggcgt atcacgaggc cctttcgtct cgcgcgtttc     7800

ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg agacggtcac agcttgtctg     7860

taagcggatg ccgggagcag acaagcccgt cagggcgcgt cagcgggtgt tggcgggtgt     7920

cggggctggc ttaactatgc ggcatcagag cagattgtac tgagagtgca ccatatgcgg     7980

tgtgaaatac cgcacagatg cgtaaggaga aaataccgca tcagattggc tat            8033


<210>  4
<211>  1358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met Glu 
                85                  90                  95      


Phe Asn Asp Ala Gln Ala Pro Lys Ser Leu Glu Val Asn Leu Thr Thr 
            100                 105                 110         


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        115                 120                 125             


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    130                 135                 140                 


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
145                 150                 155                 160 


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                165                 170                 175     


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            180                 185                 190         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        195                 200                 205             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    210                 215                 220                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
225                 230                 235                 240 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                245                 250                 255     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            260                 265                 270         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        275                 280                 285             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    290                 295                 300                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
305                 310                 315                 320 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                325                 330                 335     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            340                 345                 350         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        355                 360                 365             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    370                 375                 380                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
385                 390                 395                 400 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                405                 410                 415     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            420                 425                 430         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        435                 440                 445             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    450                 455                 460                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
465                 470                 475                 480 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                485                 490                 495     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            500                 505                 510         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        515                 520                 525             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    530                 535                 540                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
545                 550                 555                 560 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                565                 570                 575     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            580                 585                 590         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        595                 600                 605             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    610                 615                 620                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
625                 630                 635                 640 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                645                 650                 655     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            660                 665                 670         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        675                 680                 685             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    690                 695                 700                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
705                 710                 715                 720 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                725                 730                 735     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            740                 745                 750         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        755                 760                 765             


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
    770                 775                 780                 


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
785                 790                 795                 800 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
                805                 810                 815     


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
            820                 825                 830         


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
        835                 840                 845             


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
    850                 855                 860                 


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
865                 870                 875                 880 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
                885                 890                 895     


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
            900                 905                 910         


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
        915                 920                 925             


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
    930                 935                 940                 


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
945                 950                 955                 960 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
                965                 970                 975     


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
            980                 985                 990         


Gln Met Ala Tyr Arg Phe Asn Gly  Ile Gly Val Thr Gln  Asn Val Leu 
        995                 1000                 1005             


Tyr Glu  Asn Gln Lys Leu Ile  Ala Asn Gln Phe Asn  Ser Ala Ile 
    1010                 1015                 1020             


Gly Lys  Ile Gln Asp Ser Leu  Ser Ser Thr Ala Ser  Ala Leu Gly 
    1025                 1030                 1035             


Lys Leu  Gln Asp Val Val Asn  Gln Asn Ala Gln Ala  Leu Asn Thr 
    1040                 1045                 1050             


Leu Val  Lys Gln Leu Ser Ser  Asn Phe Gly Ala Ile  Ser Ser Val 
    1055                 1060                 1065             


Leu Asn  Asp Ile Leu Ser Arg  Leu Asp Lys Val Glu  Ala Glu Val 
    1070                 1075                 1080             


Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr 
    1085                 1090                 1095             


Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
    1100                 1105                 1110             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1115                 1120                 1125             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1130                 1135                 1140             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1145                 1150                 1155             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1160                 1165                 1170             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1175                 1180                 1185             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1190                 1195                 1200             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1205                 1210                 1215             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1220                 1225                 1230             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1235                 1240                 1245             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1250                 1255                 1260             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1265                 1270                 1275             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1280                 1285                 1290             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile 
    1295                 1300                 1305             


Trp Leu  Gly Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr 
    1310                 1315                 1320             


Ile Met  Leu Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly 
    1325                 1330                 1335             


Cys Cys  Ser Cys Gly Ser Cys  Cys Gly Gly Arg Tyr  Pro Tyr Asp 
    1340                 1345                 1350             


Val Pro  Asp Tyr Ala 
    1355             


<210>  5
<211>  7655
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcgtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1200

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1260

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1320

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1380

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1440

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1500

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1560

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1620

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1680

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1740

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     1800

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     1860

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     1920

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     1980

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2040

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2100

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2160

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2220

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2280

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2340

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2400

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2460

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2520

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2580

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2640

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2700

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     2760

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     2820

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     2880

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     2940

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3000

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3060

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3120

tgtgcatctt atcaaaccca aaccaactcc ccccgacgcg cccgctctgt tgcgtcacag     3180

agtattatag cctatacgat gtctttgggg gcggaaaact ccgtcgctta ctccaacaac     3240

agtatagcaa tccctacgaa ttttaccatc tccgtaacaa ctgaaatcct tcctgtgtca     3300

atgaccaaaa cttctgtcga ttgcacgatg tatatctgcg gagacagcac ggaatgtagt     3360

aacttgctcc tccagtacgg ctctttctgc acacagctca atcgggcgct gaccgggata     3420

gcggtggaac aagacaagaa cacccaggaa gtcttcgcgc aggtcaagca aatctacaag     3480

acccctccca ttaaagattt tggtggtttt aactttagcc aaatactgcc agatccgtcc     3540

aaaccctcca aacgatcctt catcgaggac ctccttttta acaaagttac cctcgccgac     3600

gccgggttca taaaacagta cggcgactgc ttgggtgaca tcgcagccag agacttgatt     3660

tgtgcgcaaa aattcaacgg ccttacggtc ctgcctccat tgctgaccga tgaaatgatt     3720

gcccagtata cctctgcttt gttggcaggg acaataactt ctgggtggac gtttggagca     3780

ggcgctgccc tgcagatccc ttttgccatg cagatggcat accggtttaa cgggatcggt     3840

gttactcaga acgtactcta tgagaatcaa aagctgatcg ccaaccaatt taatagcgcc     3900

atcggtaaaa tccaggatag tttgagcagc accgcttctg cacttgggaa gcttcaggat     3960

gttgtgaatc agaacgccca agcattgaat actctcgtca aacaattgag tagtaatttc     4020

ggagccatct catctgtgtt gaatgacata ctcagtcgcc tcgataaggt agaggctgag     4080

gtgcagatag accggcttat aactggtaga ttgcagagcc ttcagactta cgtgacgcaa     4140

cagcttatcc gagcagcaga aatcagggca tcagcaaatc ttgccgccac caaaatgtca     4200

gagtgcgtac tgggccaaag taaaagagtg gatttttgtg gaaaaggata ccacttgatg     4260

agctttcccc agtctgcccc gcacggtgtg gtcttcctgc acgtaaccta cgtgccggcg     4320

caagaaaaaa actttaccac cgctcccgcg atatgtcacg acggaaaggc gcattttccg     4380

cgagaaggcg tatttgtatc aaacggaaca cactggttcg ttacccagcg aaacttctac     4440

gagccacaga tcattactac ggataataca ttcgtctctg gtaattgcga tgtagtcata     4500

ggaatagtaa ataatacggt ttatgacccc ctccaacctg agcttgactc cttcaaagag     4560

gaacttgata aatactttaa gaatcatacc tctccggatg tcgatctcgg ggatatttct     4620

ggtatcaatg caagcgtcgt gaacatacag aaagaaatcg acagattgaa cgaagtcgcg     4680

aagaatctta acgaatctct gatagacttg caagaattgg gcaagtatga gcagggcggc     4740

cgctacccat acgacgtacc agattacgct taaagatctt tttccctctg ccaaaaatta     4800

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     4860

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc     4920

aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccattc     4980

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     5040

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     5100

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     5160

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     5220

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     5280

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     5340

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     5400

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     5460

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     5520

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     5580

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     5640

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     5700

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     5760

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     5820

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     5880

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga     5940

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tcgggggggg     6000

ggggcgctga ggtctgcctc gtgaagaagg tgttgctgac tcataccagg cctgaatcgc     6060

cccatcatcc agccagaaag tgagggagcc acggttgatg agagctttgt tgtaggtgga     6120

ccagttggtg attttgaact tttgctttgc cacggaacgg tctgcgttgt cgggaagatg     6180

cgtgatctga tccttcaact cagcaaaagt tcgatttatt caacaaagcc gccgtcccgt     6240

caagtcagcg taatgctctg ccagtgttac aaccaattaa ccaattctga ttagaaaaac     6300

tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat accatatttt     6360

tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca taggatggca     6420

agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc tattaatttc     6480

ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac tgaatccggt     6540

gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca gccattacgc     6600

tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg     6660

agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga atgcaaccgg     6720

cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata ttcttctaat     6780

acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc atcaggagta     6840

cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt tagtctgacc     6900

atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa caactctggc     6960

gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac attatcgcga     7020

gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg cctggagcaa     7080

gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat gtaagcagac     7140

agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca gagattttga     7200

gacacaacgt ggctttcccc ccccccccat tattgaagca tttatcaggg ttattgtctc     7260

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     7320

tttccccgaa aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat     7380

aaaaataggc gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac     7440

ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc     7500

agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat     7560

gcggcatcag agcagattgt actgagagtg caccatatgc ggtgtgaaat accgcacaga     7620

tgcgtaagga gaaaataccg catcagattg gctat                                7655


<210>  6
<211>  1232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Val Asn Leu Thr Thr 
            20                  25                  30          


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        35                  40                  45              


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    50                  55                  60                  


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
65                  70                  75                  80  


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                85                  90                  95      


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            100                 105                 110         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        115                 120                 125             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    130                 135                 140                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
145                 150                 155                 160 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                165                 170                 175     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            180                 185                 190         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        195                 200                 205             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    210                 215                 220                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
225                 230                 235                 240 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                245                 250                 255     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            260                 265                 270         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        275                 280                 285             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    290                 295                 300                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
305                 310                 315                 320 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                325                 330                 335     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            340                 345                 350         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        355                 360                 365             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    370                 375                 380                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
385                 390                 395                 400 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                405                 410                 415     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            420                 425                 430         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        435                 440                 445             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    450                 455                 460                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
465                 470                 475                 480 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                485                 490                 495     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            500                 505                 510         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        515                 520                 525             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    530                 535                 540                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
545                 550                 555                 560 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                565                 570                 575     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            580                 585                 590         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        595                 600                 605             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    610                 615                 620                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
625                 630                 635                 640 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                645                 650                 655     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            660                 665                 670         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        675                 680                 685             


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
    690                 695                 700                 


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
705                 710                 715                 720 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
                725                 730                 735     


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
            740                 745                 750         


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
        755                 760                 765             


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
    770                 775                 780                 


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
785                 790                 795                 800 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
                805                 810                 815     


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
            820                 825                 830         


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
        835                 840                 845             


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
    850                 855                 860                 


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
865                 870                 875                 880 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
                885                 890                 895     


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
            900                 905                 910         


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
        915                 920                 925             


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
    930                 935                 940                 


Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu 
945                 950                 955                 960 


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
                965                 970                 975     


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
            980                 985                 990         


Leu Ser Arg Leu Asp Lys Val Glu  Ala Glu Val Gln Ile  Asp Arg Leu 
        995                 1000                 1005             


Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
    1010                 1015                 1020             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1025                 1030                 1035             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1040                 1045                 1050             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1055                 1060                 1065             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1070                 1075                 1080             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1085                 1090                 1095             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1100                 1105                 1110             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1115                 1120                 1125             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1130                 1135                 1140             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1145                 1150                 1155             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1160                 1165                 1170             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1175                 1180                 1185             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1190                 1195                 1200             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1205                 1210                 1215             


Glu Gln  Gly Gly Arg Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala 
    1220                 1225                 1230         


<210>  7
<211>  7895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  7
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcaactt tgactgctgt cttggataca cagaccgtat tcttcatcct     1200

aaatttattg tgggcttcac acggcagctg gccaatgaag gctgtgacat caatgctatc     1260

atctttcaca caaagaaaaa gttgtctgtg tgcgcaaatc caaaacagac ttgggtgaaa     1320

tatattgtgc gtctcctcag taaaaaagtc aagaacatgg aattcaacga cgctcaggcg     1380

ccgaagagtc tcgaggtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1440

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1500

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1560

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1620

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1680

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1740

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1800

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1860

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1920

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1980

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     2040

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     2100

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     2160

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     2220

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2280

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2340

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2400

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2460

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2520

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2580

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2640

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2700

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2760

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2820

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2880

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2940

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     3000

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     3060

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     3120

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     3180

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3240

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3300

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3360

tgtgcatctt atcaaaccca aaccaactcc ccccgacgcg cccgctctgt tgcgtcacag     3420

agtattatag cctatacgat gtctttgggg gcggaaaact ccgtcgctta ctccaacaac     3480

agtatagcaa tccctacgaa ttttaccatc tccgtaacaa ctgaaatcct tcctgtgtca     3540

atgaccaaaa cttctgtcga ttgcacgatg tatatctgcg gagacagcac ggaatgtagt     3600

aacttgctcc tccagtacgg ctctttctgc acacagctca atcgggcgct gaccgggata     3660

gcggtggaac aagacaagaa cacccaggaa gtcttcgcgc aggtcaagca aatctacaag     3720

acccctccca ttaaagattt tggtggtttt aactttagcc aaatactgcc agatccgtcc     3780

aaaccctcca aacgatcctt catcgaggac ctccttttta acaaagttac cctcgccgac     3840

gccgggttca taaaacagta cggcgactgc ttgggtgaca tcgcagccag agacttgatt     3900

tgtgcgcaaa aattcaacgg ccttacggtc ctgcctccat tgctgaccga tgaaatgatt     3960

gcccagtata cctctgcttt gttggcaggg acaataactt ctgggtggac gtttggagca     4020

ggcgctgccc tgcagatccc ttttgccatg cagatggcat accggtttaa cgggatcggt     4080

gttactcaga acgtactcta tgagaatcaa aagctgatcg ccaaccaatt taatagcgcc     4140

atcggtaaaa tccaggatag tttgagcagc accgcttctg cacttgggaa gcttcaggat     4200

gttgtgaatc agaacgccca agcattgaat actctcgtca aacaattgag tagtaatttc     4260

ggagccatct catctgtgtt gaatgacata ctcagtcgcc tcgataaggt agaggctgag     4320

gtgcagatag accggcttat aactggtaga ttgcagagcc ttcagactta cgtgacgcaa     4380

cagcttatcc gagcagcaga aatcagggca tcagcaaatc ttgccgccac caaaatgtca     4440

gagtgcgtac tgggccaaag taaaagagtg gatttttgtg gaaaaggata ccacttgatg     4500

agctttcccc agtctgcccc gcacggtgtg gtcttcctgc acgtaaccta cgtgccggcg     4560

caagaaaaaa actttaccac cgctcccgcg atatgtcacg acggaaaggc gcattttccg     4620

cgagaaggcg tatttgtatc aaacggaaca cactggttcg ttacccagcg aaacttctac     4680

gagccacaga tcattactac ggataataca ttcgtctctg gtaattgcga tgtagtcata     4740

ggaatagtaa ataatacggt ttatgacccc ctccaacctg agcttgactc cttcaaagag     4800

gaacttgata aatactttaa gaatcatacc tctccggatg tcgatctcgg ggatatttct     4860

ggtatcaatg caagcgtcgt gaacatacag aaagaaatcg acagattgaa cgaagtcgcg     4920

aagaatctta acgaatctct gatagacttg caagaattgg gcaagtatga gcagggcggc     4980

cgctacccat acgacgtacc agattacgct taaagatctt tttccctctg ccaaaaatta     5040

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     5100

cattgcaata gtgtgttgga attttttgtg tctctcactc ggaaggacat atgggagggc     5160

aaatcattta aaacatcaga atgagtattt ggtttagagt ttggcaacat atgcccattc     5220

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     5280

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     5340

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     5400

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     5460

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     5520

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     5580

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     5640

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     5700

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     5760

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     5820

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     5880

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     5940

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     6000

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     6060

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     6120

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct taatcagtga     6180

ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac tcgggggggg     6240

ggggcgctga ggtctgcctc gtgaagaagg tgttgctgac tcataccagg cctgaatcgc     6300

cccatcatcc agccagaaag tgagggagcc acggttgatg agagctttgt tgtaggtgga     6360

ccagttggtg attttgaact tttgctttgc cacggaacgg tctgcgttgt cgggaagatg     6420

cgtgatctga tccttcaact cagcaaaagt tcgatttatt caacaaagcc gccgtcccgt     6480

caagtcagcg taatgctctg ccagtgttac aaccaattaa ccaattctga ttagaaaaac     6540

tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat accatatttt     6600

tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca taggatggca     6660

agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc tattaatttc     6720

ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac tgaatccggt     6780

gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca gccattacgc     6840

tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg     6900

agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga atgcaaccgg     6960

cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata ttcttctaat     7020

acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc atcaggagta     7080

cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt tagtctgacc     7140

atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa caactctggc     7200

gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac attatcgcga     7260

gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg cctggagcaa     7320

gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat gtaagcagac     7380

agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca gagattttga     7440

gacacaacgt ggctttcccc ccccccccat tattgaagca tttatcaggg ttattgtctc     7500

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     7560

tttccccgaa aagtgccacc tgacgtctaa gaaaccatta ttatcatgac attaacctat     7620

aaaaataggc gtatcacgag gccctttcgt ctcgcgcgtt tcggtgatga cggtgaaaac     7680

ctctgacaca tgcagctccc ggagacggtc acagcttgtc tgtaagcgga tgccgggagc     7740

agacaagccc gtcagggcgc gtcagcgggt gttggcgggt gtcggggctg gcttaactat     7800

gcggcatcag agcagattgt actgagagtg caccatatgc ggtgtgaaat accgcacaga     7860

tgcgtaagga gaaaataccg catcagattg gctat                                7895


<210>  8
<211>  1312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  8

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met Glu 
                85                  90                  95      


Phe Asn Asp Ala Gln Ala Pro Lys Ser Leu Glu Val Asn Leu Thr Thr 
            100                 105                 110         


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        115                 120                 125             


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    130                 135                 140                 


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
145                 150                 155                 160 


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                165                 170                 175     


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            180                 185                 190         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        195                 200                 205             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    210                 215                 220                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
225                 230                 235                 240 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                245                 250                 255     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            260                 265                 270         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        275                 280                 285             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    290                 295                 300                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
305                 310                 315                 320 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                325                 330                 335     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            340                 345                 350         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        355                 360                 365             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    370                 375                 380                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
385                 390                 395                 400 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                405                 410                 415     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            420                 425                 430         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        435                 440                 445             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    450                 455                 460                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
465                 470                 475                 480 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                485                 490                 495     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            500                 505                 510         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        515                 520                 525             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    530                 535                 540                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
545                 550                 555                 560 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                565                 570                 575     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            580                 585                 590         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        595                 600                 605             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    610                 615                 620                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
625                 630                 635                 640 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                645                 650                 655     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            660                 665                 670         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        675                 680                 685             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    690                 695                 700                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
705                 710                 715                 720 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                725                 730                 735     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            740                 745                 750         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        755                 760                 765             


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
    770                 775                 780                 


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
785                 790                 795                 800 


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
                805                 810                 815     


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
            820                 825                 830         


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
        835                 840                 845             


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
    850                 855                 860                 


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
865                 870                 875                 880 


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
                885                 890                 895     


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
            900                 905                 910         


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
        915                 920                 925             


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
    930                 935                 940                 


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
945                 950                 955                 960 


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
                965                 970                 975     


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
            980                 985                 990         


Gln Met Ala Tyr Arg Phe Asn Gly  Ile Gly Val Thr Gln  Asn Val Leu 
        995                 1000                 1005             


Tyr Glu  Asn Gln Lys Leu Ile  Ala Asn Gln Phe Asn  Ser Ala Ile 
    1010                 1015                 1020             


Gly Lys  Ile Gln Asp Ser Leu  Ser Ser Thr Ala Ser  Ala Leu Gly 
    1025                 1030                 1035             


Lys Leu  Gln Asp Val Val Asn  Gln Asn Ala Gln Ala  Leu Asn Thr 
    1040                 1045                 1050             


Leu Val  Lys Gln Leu Ser Ser  Asn Phe Gly Ala Ile  Ser Ser Val 
    1055                 1060                 1065             


Leu Asn  Asp Ile Leu Ser Arg  Leu Asp Lys Val Glu  Ala Glu Val 
    1070                 1075                 1080             


Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr 
    1085                 1090                 1095             


Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
    1100                 1105                 1110             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1115                 1120                 1125             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1130                 1135                 1140             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1145                 1150                 1155             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1160                 1165                 1170             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1175                 1180                 1185             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1190                 1195                 1200             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1205                 1210                 1215             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1220                 1225                 1230             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1235                 1240                 1245             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1250                 1255                 1260             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1265                 1270                 1275             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1280                 1285                 1290             


Glu Leu  Gly Lys Tyr Glu Gln  Gly Gly Arg Tyr Pro  Tyr Asp Val 
    1295                 1300                 1305             


Pro Asp  Tyr Ala 
    1310         


<210>  9
<211>  7631
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcgtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1200

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1260

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1320

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1380

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1440

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1500

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1560

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1620

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1680

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1740

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     1800

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     1860

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     1920

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     1980

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2040

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2100

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2160

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2220

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2280

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2340

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2400

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2460

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2520

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2580

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2640

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2700

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     2760

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     2820

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     2880

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     2940

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3000

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3060

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3120

tgtgcatctt atcaaaccca aaccaactcc ccctctgttg cgtcacagag tattatagcc     3180

tatacgatgt ctttgggggc ggaaaactcc gtcgcttact ccaacaacag tatagcaatc     3240

cctacgaatt ttaccatctc cgtaacaact gaaatccttc ctgtgtcaat gaccaaaact     3300

tctgtcgatt gcacgatgta tatctgcgga gacagcacgg aatgtagtaa cttgctcctc     3360

cagtacggct ctttctgcac acagctcaat cgggcgctga ccgggatagc ggtggaacaa     3420

gacaagaaca cccaggaagt cttcgcgcag gtcaagcaaa tctacaagac ccctcccatt     3480

aaagattttg gtggttttaa ctttagccaa atactgccag atccgtccaa atccttcatc     3540

gaggacctcc tttttaacaa agttaccctc gccgacgccg ggttcataaa acagtacggc     3600

gactgcttgg gtgacatcgc agccagagac ttgatttgtg cgcaaaaatt caacggcctt     3660

acggtcctgc ctccattgct gaccgatgaa atgattgccc agtatacctc tgctttgttg     3720

gcagggacaa taacttctgg gtggacgttt ggagcaggcg ctgccctgca gatccctttt     3780

gccatgcaga tggcataccg gtttaacggg atcggtgtta ctcagaacgt actctatgag     3840

aatcaaaagc tgatcgccaa ccaatttaat agcgccatcg gtaaaatcca ggatagtttg     3900

agcagcaccg cttctgcact tgggaagctt caggatgttg tgaatcagaa cgcccaagca     3960

ttgaatactc tcgtcaaaca attgagtagt aatttcggag ccatctcatc tgtgttgaat     4020

gacatactca gtcgcctcga taaggtagag gctgaggtgc agatagaccg gcttataact     4080

ggtagattgc agagccttca gacttacgtg acgcaacagc ttatccgagc agcagaaatc     4140

agggcatcag caaatcttgc cgccaccaaa atgtcagagt gcgtactggg ccaaagtaaa     4200

agagtggatt tttgtggaaa aggataccac ttgatgagct ttccccagtc tgccccgcac     4260

ggtgtggtct tcctgcacgt aacctacgtg ccggcgcaag aaaaaaactt taccaccgct     4320

cccgcgatat gtcacgacgg aaaggcgcat tttccgcgag aaggcgtatt tgtatcaaac     4380

ggaacacact ggttcgttac ccagcgaaac ttctacgagc cacagatcat tactacggat     4440

aatacattcg tctctggtaa ttgcgatgta gtcataggaa tagtaaataa tacggtttat     4500

gaccccctcc aacctgagct tgactccttc aaagaggaac ttgataaata ctttaagaat     4560

catacctctc cggatgtcga tctcggggat atttctggta tcaatgcaag cgtcgtgaac     4620

atacagaaag aaatcgacag attgaacgaa gtcgcgaaga atcttaacga atctctgata     4680

gacttgcaag aattgggcaa gtatgagcag ggcggccgct acccatacga cgtaccagat     4740

tacgcttaaa gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     4800

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     4860

tttgtgtctc tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga     4920

gtatttggtt tagagtttgg caacatatgc ccattcttcc gcttcctcgc tcactgactc     4980

gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg     5040

gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa     5100

ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga     5160

cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag     5220

ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct     5280

taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg     5340

ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc     5400

ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt     5460

aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta     5520

tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac     5580

agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc     5640

ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat     5700

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc     5760

tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt     5820

cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta     5880

aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct     5940

atttcgttca tccatagttg cctgactcgg gggggggggg cgctgaggtc tgcctcgtga     6000

agaaggtgtt gctgactcat accaggcctg aatcgcccca tcatccagcc agaaagtgag     6060

ggagccacgg ttgatgagag ctttgttgta ggtggaccag ttggtgattt tgaacttttg     6120

ctttgccacg gaacggtctg cgttgtcggg aagatgcgtg atctgatcct tcaactcagc     6180

aaaagttcga tttattcaac aaagccgccg tcccgtcaag tcagcgtaat gctctgccag     6240

tgttacaacc aattaaccaa ttctgattag aaaaactcat cgagcatcaa atgaaactgc     6300

aatttattca tatcaggatt atcaatacca tatttttgaa aaagccgttt ctgtaatgaa     6360

ggagaaaact caccgaggca gttccatagg atggcaagat cctggtatcg gtctgcgatt     6420

ccgactcgtc caacatcaat acaacctatt aatttcccct cgtcaaaaat aaggttatca     6480

agtgagaaat caccatgagt gacgactgaa tccggtgaga atggcaaaag cttatgcatt     6540

tctttccaga cttgttcaac aggccagcca ttacgctcgt catcaaaatc actcgcatca     6600

accaaaccgt tattcattcg tgattgcgcc tgagcgagac gaaatacgcg atcgctgtta     6660

aaaggacaat tacaaacagg aatcgaatgc aaccggcgca ggaacactgc cagcgcatca     6720

acaatatttt cacctgaatc aggatattct tctaatacct ggaatgctgt tttcccgggg     6780

atcgcagtgg tgagtaacca tgcatcatca ggagtacgga taaaatgctt gatggtcgga     6840

agaggcataa attccgtcag ccagtttagt ctgaccatct catctgtaac atcattggca     6900

acgctacctt tgccatgttt cagaaacaac tctggcgcat cgggcttccc atacaatcga     6960

tagattgtcg cacctgattg cccgacatta tcgcgagccc atttataccc atataaatca     7020

gcatccatgt tggaatttaa tcgcggcctg gagcaagacg tttcccgttg aatatggctc     7080

ataacacccc ttgtattact gtttatgtaa gcagacagtt ttattgttca tgatgatata     7140

tttttatctt gtgcaatgta acatcagaga ttttgagaca caacgtggct ttcccccccc     7200

ccccattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     7260

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac     7320

gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc     7380

tttcgtctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag     7440

acggtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca     7500

gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg catcagagca gattgtactg     7560

agagtgcacc atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc     7620

agattggcta t                                                          7631


<210>  10
<211>  1224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  10

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Val Asn Leu Thr Thr 
            20                  25                  30          


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        35                  40                  45              


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    50                  55                  60                  


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
65                  70                  75                  80  


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                85                  90                  95      


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            100                 105                 110         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        115                 120                 125             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    130                 135                 140                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
145                 150                 155                 160 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                165                 170                 175     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            180                 185                 190         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        195                 200                 205             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    210                 215                 220                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
225                 230                 235                 240 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                245                 250                 255     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            260                 265                 270         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        275                 280                 285             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    290                 295                 300                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
305                 310                 315                 320 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                325                 330                 335     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            340                 345                 350         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        355                 360                 365             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    370                 375                 380                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
385                 390                 395                 400 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                405                 410                 415     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            420                 425                 430         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        435                 440                 445             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    450                 455                 460                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
465                 470                 475                 480 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                485                 490                 495     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            500                 505                 510         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        515                 520                 525             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    530                 535                 540                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
545                 550                 555                 560 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                565                 570                 575     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            580                 585                 590         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        595                 600                 605             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    610                 615                 620                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
625                 630                 635                 640 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                645                 650                 655     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            660                 665                 670         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        675                 680                 685             


Gln Thr Asn Ser Pro Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr 
    690                 695                 700                 


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
705                 710                 715                 720 


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
                725                 730                 735     


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
            740                 745                 750         


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
        755                 760                 765             


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
    770                 775                 780                 


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
785                 790                 795                 800 


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
                805                 810                 815     


Pro Ser Lys Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
            820                 825                 830         


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
        835                 840                 845             


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
    850                 855                 860                 


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
865                 870                 875                 880 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
                885                 890                 895     


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
            900                 905                 910         


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
        915                 920                 925             


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
    930                 935                 940                 


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
945                 950                 955                 960 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
                965                 970                 975     


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
            980                 985                 990         


Ala Glu Val Gln Ile Asp Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu 
        995                 1000                 1005             


Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
    1010                 1015                 1020             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1025                 1030                 1035             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1040                 1045                 1050             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1055                 1060                 1065             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1070                 1075                 1080             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1085                 1090                 1095             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1100                 1105                 1110             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1115                 1120                 1125             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1130                 1135                 1140             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1145                 1150                 1155             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1160                 1165                 1170             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1175                 1180                 1185             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1190                 1195                 1200             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Gly Gly Arg  Tyr Pro Tyr 
    1205                 1210                 1215             


Asp Val  Pro Asp Tyr Ala 
    1220                 


<210>  11
<211>  7871
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcaactt tgactgctgt cttggataca cagaccgtat tcttcatcct     1200

aaatttattg tgggcttcac acggcagctg gccaatgaag gctgtgacat caatgctatc     1260

atctttcaca caaagaaaaa gttgtctgtg tgcgcaaatc caaaacagac ttgggtgaaa     1320

tatattgtgc gtctcctcag taaaaaagtc aagaacatgg aattcaacga cgctcaggcg     1380

ccgaagagtc tcgaggtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1440

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1500

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1560

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1620

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1680

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1740

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1800

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1860

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1920

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1980

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     2040

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     2100

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     2160

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     2220

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2280

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2340

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2400

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2460

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2520

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2580

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2640

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2700

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2760

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2820

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2880

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2940

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     3000

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     3060

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     3120

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     3180

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3240

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3300

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3360

tgtgcatctt atcaaaccca aaccaactcc ccctctgttg cgtcacagag tattatagcc     3420

tatacgatgt ctttgggggc ggaaaactcc gtcgcttact ccaacaacag tatagcaatc     3480

cctacgaatt ttaccatctc cgtaacaact gaaatccttc ctgtgtcaat gaccaaaact     3540

tctgtcgatt gcacgatgta tatctgcgga gacagcacgg aatgtagtaa cttgctcctc     3600

cagtacggct ctttctgcac acagctcaat cgggcgctga ccgggatagc ggtggaacaa     3660

gacaagaaca cccaggaagt cttcgcgcag gtcaagcaaa tctacaagac ccctcccatt     3720

aaagattttg gtggttttaa ctttagccaa atactgccag atccgtccaa atccttcatc     3780

gaggacctcc tttttaacaa agttaccctc gccgacgccg ggttcataaa acagtacggc     3840

gactgcttgg gtgacatcgc agccagagac ttgatttgtg cgcaaaaatt caacggcctt     3900

acggtcctgc ctccattgct gaccgatgaa atgattgccc agtatacctc tgctttgttg     3960

gcagggacaa taacttctgg gtggacgttt ggagcaggcg ctgccctgca gatccctttt     4020

gccatgcaga tggcataccg gtttaacggg atcggtgtta ctcagaacgt actctatgag     4080

aatcaaaagc tgatcgccaa ccaatttaat agcgccatcg gtaaaatcca ggatagtttg     4140

agcagcaccg cttctgcact tgggaagctt caggatgttg tgaatcagaa cgcccaagca     4200

ttgaatactc tcgtcaaaca attgagtagt aatttcggag ccatctcatc tgtgttgaat     4260

gacatactca gtcgcctcga taaggtagag gctgaggtgc agatagaccg gcttataact     4320

ggtagattgc agagccttca gacttacgtg acgcaacagc ttatccgagc agcagaaatc     4380

agggcatcag caaatcttgc cgccaccaaa atgtcagagt gcgtactggg ccaaagtaaa     4440

agagtggatt tttgtggaaa aggataccac ttgatgagct ttccccagtc tgccccgcac     4500

ggtgtggtct tcctgcacgt aacctacgtg ccggcgcaag aaaaaaactt taccaccgct     4560

cccgcgatat gtcacgacgg aaaggcgcat tttccgcgag aaggcgtatt tgtatcaaac     4620

ggaacacact ggttcgttac ccagcgaaac ttctacgagc cacagatcat tactacggat     4680

aatacattcg tctctggtaa ttgcgatgta gtcataggaa tagtaaataa tacggtttat     4740

gaccccctcc aacctgagct tgactccttc aaagaggaac ttgataaata ctttaagaat     4800

catacctctc cggatgtcga tctcggggat atttctggta tcaatgcaag cgtcgtgaac     4860

atacagaaag aaatcgacag attgaacgaa gtcgcgaaga atcttaacga atctctgata     4920

gacttgcaag aattgggcaa gtatgagcag ggcggccgct acccatacga cgtaccagat     4980

tacgcttaaa gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga     5040

gcatctgact tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt     5100

tttgtgtctc tcactcggaa ggacatatgg gagggcaaat catttaaaac atcagaatga     5160

gtatttggtt tagagtttgg caacatatgc ccattcttcc gcttcctcgc tcactgactc     5220

gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg     5280

gttatccaca gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa     5340

ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga     5400

cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag     5460

ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct     5520

taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg     5580

ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc     5640

ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt     5700

aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta     5760

tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac     5820

agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc     5880

ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat     5940

tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc     6000

tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt     6060

cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta     6120

aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag cgatctgtct     6180

atttcgttca tccatagttg cctgactcgg gggggggggg cgctgaggtc tgcctcgtga     6240

agaaggtgtt gctgactcat accaggcctg aatcgcccca tcatccagcc agaaagtgag     6300

ggagccacgg ttgatgagag ctttgttgta ggtggaccag ttggtgattt tgaacttttg     6360

ctttgccacg gaacggtctg cgttgtcggg aagatgcgtg atctgatcct tcaactcagc     6420

aaaagttcga tttattcaac aaagccgccg tcccgtcaag tcagcgtaat gctctgccag     6480

tgttacaacc aattaaccaa ttctgattag aaaaactcat cgagcatcaa atgaaactgc     6540

aatttattca tatcaggatt atcaatacca tatttttgaa aaagccgttt ctgtaatgaa     6600

ggagaaaact caccgaggca gttccatagg atggcaagat cctggtatcg gtctgcgatt     6660

ccgactcgtc caacatcaat acaacctatt aatttcccct cgtcaaaaat aaggttatca     6720

agtgagaaat caccatgagt gacgactgaa tccggtgaga atggcaaaag cttatgcatt     6780

tctttccaga cttgttcaac aggccagcca ttacgctcgt catcaaaatc actcgcatca     6840

accaaaccgt tattcattcg tgattgcgcc tgagcgagac gaaatacgcg atcgctgtta     6900

aaaggacaat tacaaacagg aatcgaatgc aaccggcgca ggaacactgc cagcgcatca     6960

acaatatttt cacctgaatc aggatattct tctaatacct ggaatgctgt tttcccgggg     7020

atcgcagtgg tgagtaacca tgcatcatca ggagtacgga taaaatgctt gatggtcgga     7080

agaggcataa attccgtcag ccagtttagt ctgaccatct catctgtaac atcattggca     7140

acgctacctt tgccatgttt cagaaacaac tctggcgcat cgggcttccc atacaatcga     7200

tagattgtcg cacctgattg cccgacatta tcgcgagccc atttataccc atataaatca     7260

gcatccatgt tggaatttaa tcgcggcctg gagcaagacg tttcccgttg aatatggctc     7320

ataacacccc ttgtattact gtttatgtaa gcagacagtt ttattgttca tgatgatata     7380

tttttatctt gtgcaatgta acatcagaga ttttgagaca caacgtggct ttcccccccc     7440

ccccattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     7500

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccacctgac     7560

gtctaagaaa ccattattat catgacatta acctataaaa ataggcgtat cacgaggccc     7620

tttcgtctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag     7680

acggtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca     7740

gcgggtgttg gcgggtgtcg gggctggctt aactatgcgg catcagagca gattgtactg     7800

agagtgcacc atatgcggtg tgaaataccg cacagatgcg taaggagaaa ataccgcatc     7860

agattggcta t                                                          7871


<210>  12
<211>  1304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  12

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met Glu 
                85                  90                  95      


Phe Asn Asp Ala Gln Ala Pro Lys Ser Leu Glu Val Asn Leu Thr Thr 
            100                 105                 110         


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        115                 120                 125             


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    130                 135                 140                 


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
145                 150                 155                 160 


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                165                 170                 175     


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            180                 185                 190         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        195                 200                 205             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    210                 215                 220                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
225                 230                 235                 240 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                245                 250                 255     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            260                 265                 270         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        275                 280                 285             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    290                 295                 300                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
305                 310                 315                 320 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                325                 330                 335     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            340                 345                 350         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        355                 360                 365             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    370                 375                 380                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
385                 390                 395                 400 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                405                 410                 415     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            420                 425                 430         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        435                 440                 445             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    450                 455                 460                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
465                 470                 475                 480 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                485                 490                 495     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            500                 505                 510         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        515                 520                 525             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    530                 535                 540                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
545                 550                 555                 560 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                565                 570                 575     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            580                 585                 590         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        595                 600                 605             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    610                 615                 620                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
625                 630                 635                 640 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                645                 650                 655     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            660                 665                 670         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        675                 680                 685             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    690                 695                 700                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
705                 710                 715                 720 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                725                 730                 735     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            740                 745                 750         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        755                 760                 765             


Gln Thr Asn Ser Pro Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr 
    770                 775                 780                 


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
785                 790                 795                 800 


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
                805                 810                 815     


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
            820                 825                 830         


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
        835                 840                 845             


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
    850                 855                 860                 


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
865                 870                 875                 880 


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
                885                 890                 895     


Pro Ser Lys Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
            900                 905                 910         


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
        915                 920                 925             


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
    930                 935                 940                 


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
945                 950                 955                 960 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
                965                 970                 975     


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
            980                 985                 990         


Ile Gly Val Thr Gln Asn Val Leu  Tyr Glu Asn Gln Lys  Leu Ile Ala 
        995                 1000                 1005             


Asn Gln  Phe Asn Ser Ala Ile  Gly Lys Ile Gln Asp  Ser Leu Ser 
    1010                 1015                 1020             


Ser Thr  Ala Ser Ala Leu Gly  Lys Leu Gln Asp Val  Val Asn Gln 
    1025                 1030                 1035             


Asn Ala  Gln Ala Leu Asn Thr  Leu Val Lys Gln Leu  Ser Ser Asn 
    1040                 1045                 1050             


Phe Gly  Ala Ile Ser Ser Val  Leu Asn Asp Ile Leu  Ser Arg Leu 
    1055                 1060                 1065             


Asp Lys  Val Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
    1070                 1075                 1080             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1085                 1090                 1095             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1100                 1105                 1110             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1115                 1120                 1125             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1130                 1135                 1140             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1145                 1150                 1155             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1160                 1165                 1170             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1175                 1180                 1185             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1190                 1195                 1200             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1205                 1210                 1215             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1220                 1225                 1230             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1235                 1240                 1245             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1250                 1255                 1260             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1265                 1270                 1275             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Gly 
    1280                 1285                 1290             


Gly Arg  Tyr Pro Tyr Asp Val  Pro Asp Tyr Ala 
    1295                 1300                 


<210>  13
<211>  7727
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcgtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1200

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1260

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1320

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1380

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1440

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1500

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1560

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1620

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1680

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1740

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     1800

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     1860

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     1920

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     1980

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2040

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2100

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2160

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2220

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2280

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2340

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2400

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2460

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2520

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2580

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2640

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2700

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     2760

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     2820

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     2880

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     2940

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3000

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3060

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3120

tgtgcatctt atcaaaccca aaccaactcc ccctctggtg ggggaggctc aggcggaggt     3180

ggtagcgggg gcggtggttc atctgttgcg tcacagagta ttatagccta tacgatgtct     3240

ttgggggcgg aaaactccgt cgcttactcc aacaacagta tagcaatccc tacgaatttt     3300

accatctccg taacaactga aatccttcct gtgtcaatga ccaaaacttc tgtcgattgc     3360

acgatgtata tctgcggaga cagcacggaa tgtagtaact tgctcctcca gtacggctct     3420

ttctgcacac agctcaatcg ggcgctgacc gggatagcgg tggaacaaga caagaacacc     3480

caggaagtct tcgcgcaggt caagcaaatc tacaagaccc ctcccattaa agattttggt     3540

ggttttaact ttagccaaat actgccagat ccgtccaaat ctgggggtgg gggaagtggg     3600

ggagggggga gcggcggagg aggtagttcc ttcatcgagg acctcctttt taacaaagtt     3660

accctcgccg acgccgggtt cataaaacag tacggcgact gcttgggtga catcgcagcc     3720

agagacttga tttgtgcgca aaaattcaac ggccttacgg tcctgcctcc attgctgacc     3780

gatgaaatga ttgcccagta tacctctgct ttgttggcag ggacaataac ttctgggtgg     3840

acgtttggag caggcgctgc cctgcagatc ccttttgcca tgcagatggc ataccggttt     3900

aacgggatcg gtgttactca gaacgtactc tatgagaatc aaaagctgat cgccaaccaa     3960

tttaatagcg ccatcggtaa aatccaggat agtttgagca gcaccgcttc tgcacttggg     4020

aagcttcagg atgttgtgaa tcagaacgcc caagcattga atactctcgt caaacaattg     4080

agtagtaatt tcggagccat ctcatctgtg ttgaatgaca tactcagtcg cctcgataag     4140

gtagaggctg aggtgcagat agaccggctt ataactggta gattgcagag ccttcagact     4200

tacgtgacgc aacagcttat ccgagcagca gaaatcaggg catcagcaaa tcttgccgcc     4260

accaaaatgt cagagtgcgt actgggccaa agtaaaagag tggatttttg tggaaaagga     4320

taccacttga tgagctttcc ccagtctgcc ccgcacggtg tggtcttcct gcacgtaacc     4380

tacgtgccgg cgcaagaaaa aaactttacc accgctcccg cgatatgtca cgacggaaag     4440

gcgcattttc cgcgagaagg cgtatttgta tcaaacggaa cacactggtt cgttacccag     4500

cgaaacttct acgagccaca gatcattact acggataata cattcgtctc tggtaattgc     4560

gatgtagtca taggaatagt aaataatacg gtttatgacc ccctccaacc tgagcttgac     4620

tccttcaaag aggaacttga taaatacttt aagaatcata cctctccgga tgtcgatctc     4680

ggggatattt ctggtatcaa tgcaagcgtc gtgaacatac agaaagaaat cgacagattg     4740

aacgaagtcg cgaagaatct taacgaatct ctgatagact tgcaagaatt gggcaagtat     4800

gagcagggcg gccgctaccc atacgacgta ccagattacg cttaaagatc tttttccctc     4860

tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag     4920

gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac     4980

atatgggagg gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac     5040

atatgcccat tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg     5100

gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa     5160

cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc     5220

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc     5280

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag     5340

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct     5400

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta     5460

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc     5520

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc     5580

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     5640

gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct     5700

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     5760

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     5820

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     5880

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     5940

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     6000

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     6060

actcgggggg ggggggcgct gaggtctgcc tcgtgaagaa ggtgttgctg actcatacca     6120

ggcctgaatc gccccatcat ccagccagaa agtgagggag ccacggttga tgagagcttt     6180

gttgtaggtg gaccagttgg tgattttgaa cttttgcttt gccacggaac ggtctgcgtt     6240

gtcgggaaga tgcgtgatct gatccttcaa ctcagcaaaa gttcgattta ttcaacaaag     6300

ccgccgtccc gtcaagtcag cgtaatgctc tgccagtgtt acaaccaatt aaccaattct     6360

gattagaaaa actcatcgag catcaaatga aactgcaatt tattcatatc aggattatca     6420

ataccatatt tttgaaaaag ccgtttctgt aatgaaggag aaaactcacc gaggcagttc     6480

cataggatgg caagatcctg gtatcggtct gcgattccga ctcgtccaac atcaatacaa     6540

cctattaatt tcccctcgtc aaaaataagg ttatcaagtg agaaatcacc atgagtgacg     6600

actgaatccg gtgagaatgg caaaagctta tgcatttctt tccagacttg ttcaacaggc     6660

cagccattac gctcgtcatc aaaatcactc gcatcaacca aaccgttatt cattcgtgat     6720

tgcgcctgag cgagacgaaa tacgcgatcg ctgttaaaag gacaattaca aacaggaatc     6780

gaatgcaacc ggcgcaggaa cactgccagc gcatcaacaa tattttcacc tgaatcagga     6840

tattcttcta atacctggaa tgctgttttc ccggggatcg cagtggtgag taaccatgca     6900

tcatcaggag tacggataaa atgcttgatg gtcggaagag gcataaattc cgtcagccag     6960

tttagtctga ccatctcatc tgtaacatca ttggcaacgc tacctttgcc atgtttcaga     7020

aacaactctg gcgcatcggg cttcccatac aatcgataga ttgtcgcacc tgattgcccg     7080

acattatcgc gagcccattt atacccatat aaatcagcat ccatgttgga atttaatcgc     7140

ggcctggagc aagacgtttc ccgttgaata tggctcataa caccccttgt attactgttt     7200

atgtaagcag acagttttat tgttcatgat gatatatttt tatcttgtgc aatgtaacat     7260

cagagatttt gagacacaac gtggctttcc cccccccccc attattgaag catttatcag     7320

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     7380

gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg     7440

acattaacct ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat     7500

gacggtgaaa acctctgaca catgcagctc ccggagacgg tcacagcttg tctgtaagcg     7560

gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc     7620

tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat gcggtgtgaa     7680

ataccgcaca gatgcgtaag gagaaaatac cgcatcagat tggctat                   7727


<210>  14
<211>  1256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  14

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Val Asn Leu Thr Thr 
            20                  25                  30          


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        35                  40                  45              


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    50                  55                  60                  


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
65                  70                  75                  80  


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                85                  90                  95      


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            100                 105                 110         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        115                 120                 125             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    130                 135                 140                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
145                 150                 155                 160 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                165                 170                 175     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            180                 185                 190         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        195                 200                 205             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    210                 215                 220                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
225                 230                 235                 240 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                245                 250                 255     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            260                 265                 270         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        275                 280                 285             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    290                 295                 300                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
305                 310                 315                 320 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                325                 330                 335     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            340                 345                 350         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        355                 360                 365             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    370                 375                 380                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
385                 390                 395                 400 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                405                 410                 415     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            420                 425                 430         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        435                 440                 445             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    450                 455                 460                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
465                 470                 475                 480 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                485                 490                 495     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            500                 505                 510         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        515                 520                 525             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    530                 535                 540                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
545                 550                 555                 560 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                565                 570                 575     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            580                 585                 590         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        595                 600                 605             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    610                 615                 620                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
625                 630                 635                 640 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                645                 650                 655     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            660                 665                 670         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        675                 680                 685             


Gln Thr Asn Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Gly Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr 
705                 710                 715                 720 


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
                725                 730                 735     


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
            740                 745                 750         


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
        755                 760                 765             


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
    770                 775                 780                 


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
785                 790                 795                 800 


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
                805                 810                 815     


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
            820                 825                 830         


Pro Ser Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        835                 840                 845             


Gly Gly Ser Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
    850                 855                 860                 


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
865                 870                 875                 880 


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
                885                 890                 895     


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
            900                 905                 910         


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
        915                 920                 925             


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
    930                 935                 940                 


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
945                 950                 955                 960 


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
                965                 970                 975     


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
            980                 985                 990         


Gln Ala Leu Asn Thr Leu Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala 
        995                 1000                 1005             


Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
    1010                 1015                 1020             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1025                 1030                 1035             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1040                 1045                 1050             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1055                 1060                 1065             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1070                 1075                 1080             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1085                 1090                 1095             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1100                 1105                 1110             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1115                 1120                 1125             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1130                 1135                 1140             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1145                 1150                 1155             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1160                 1165                 1170             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1175                 1180                 1185             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1190                 1195                 1200             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1205                 1210                 1215             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1220                 1225                 1230             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Gly  Gly Arg Tyr 
    1235                 1240                 1245             


Pro Tyr  Asp Val Pro Asp Tyr  Ala 
    1250                 1255     


<210>  15
<211>  7967
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
tggccattgc atacgttgta tccatatcat aatatgtaca tttatattgg ctcatgtcca       60

acattaccgc catgttgaca ttgattattg actagttatt aatagtaatc aattacgggg      120

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      180

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      240

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      300

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      360

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      420

cagtacatct acgtattagt catcgctatt accatggtga tgcggttttg gcagtacatc      480

aatgggcgtg gatagcggtt tgactcacgg ggatttccaa gtctccaccc cattgacgtc      540

aatgggagtt tgttttggca ccaaaatcaa cgggactttc caaaatgtcg taacaactcc      600

gccccattga cgcaaatggg cggtaggcgt gtacggtggg aggtctatat aagcagagct      660

cgtttagtga accgtcagat cgcctggaga cgccatccac gctgttttga cctccataga      720

agacaccggg accgatccag cctccgcggc cgggaacggt gcattggaac gcggattccc      780

cgtgccaaga gtgacgtaag taccgcctat agactctata ggcacacccc tttggctctt      840

atgcatgcta tactgttttt ggcttggggc ctatacaccc ccgcttcctt atgctatagg      900

tgatggtata gcttagccta taggtgtggg ttattgacca ttattgacca ctccaacggt      960

ggagggcagt gtagtctgag cagtactcgt tgctgccgcg cgcgccacca gacataatag     1020

ctgacagact aacagactgt tcctttccat gggtcttttc tgcaggccgc caccatgtgc     1080

tgtaccaaga gtttgctcct ggctgctttg atgtcagtgc tgctactcca cctctgcggc     1140

gaatcagaag caagcaactt tgactgctgt cttggataca cagaccgtat tcttcatcct     1200

aaatttattg tgggcttcac acggcagctg gccaatgaag gctgtgacat caatgctatc     1260

atctttcaca caaagaaaaa gttgtctgtg tgcgcaaatc caaaacagac ttgggtgaaa     1320

tatattgtgc gtctcctcag taaaaaagtc aagaacatgg aattcaacga cgctcaggcg     1380

ccgaagagtc tcgaggtgaa tttgaccacc aggacccagc ttccgcctgc ctataccaat     1440

tcatttacca gaggtgtata ttacccggat aaagtgttcc gatcctcagt tctccattct     1500

acacaagact tgttcctccc cttcttctca aatgtgactt ggtttcacgc aatccatgtg     1560

tctggaacga atggcaccaa gaggtttgac aatccagtct tgccttttaa tgatggtgtc     1620

tatttcgcta gcacggaaaa aagcaatata atacggggtt ggatcttcgg cactacactt     1680

gacagtaaaa cgcagagcct tcttatagtg aataacgcta ccaacgtggt aataaaagtg     1740

tgtgagttcc aattctgcaa tgatccattc ttgggcgtgt attaccataa aaataacaaa     1800

agttggatgg aaagcgaatt ccgcgtgtac agctctgcca acaactgcac ttttgagtat     1860

gtgagccagc catttttgat ggatctggaa ggaaagcaag gtaactttaa aaacttgcgg     1920

gagttcgttt ttaagaacat cgatgggtat ttcaaaatct actcaaaaca cactcctatt     1980

aatttggttc gcgatttgcc acagggtttc tctgccctcg aacctcttgt tgatctccct     2040

attggaataa atatcacgag attccagaca ttgctcgccc tgcatcgctc atatctgaca     2100

cctggtgata gcagcagcgg atggacggca ggcgcagccg cgtattacgt tggctacttg     2160

caacccagaa catttctcct taagtataat gagaatggta cgatcactga tgcggtcgac     2220

tgcgcgttgg accctctgag cgagacaaaa tgcactctca agagtttcac tgtcgagaaa     2280

ggcatttacc aaacatctaa tttccgagtg caaccaactg agtccattgt tcgattccca     2340

aacattacta acttgtgtcc tttcggcgaa gtgttcaacg caacgagatt tgcaagtgta     2400

tacgcgtgga accgaaagag aatcagcaac tgtgtagccg attattctgt tctgtacaat     2460

agcgctagct tcagcacttt caaatgctac ggtgtaagtc ctacaaagct gaatgacctc     2520

tgtttcacaa atgtgtacgc ggatagcttc gtcattaggg gagatgaagt acggcaaatc     2580

gcccccggtc aaacagggaa gatagctgac tacaactata aacttccgga tgattttacg     2640

gggtgtgtta tagcgtggaa ttctaacaac ctcgattcaa aggtcggggg aaattacaat     2700

tacctttacc gcctgttccg aaagtcaaat cttaagccat tcgaaaggga catatcaacg     2760

gaaatttatc aagccgggtc tactccatgc aatggcgtcg agggttttaa ttgctatttt     2820

ccactgcaat cttacggttt ccaaccaacg aacggagtag gatatcaacc ttaccgggtt     2880

gtagtgttgt ctttcgaact gctccacgcg ccagctaccg tgtgcggtcc gaaaaaaagc     2940

acaaatctgg ttaagaacaa gtgtgttaac ttcaacttta acggtctcac tggaacaggt     3000

gtacttacag aatccaataa gaaatttctt ccgttccaac agttcggtag agacattgcg     3060

gacaccactg atgctgtgcg agatcctcag acactcgaaa tactggacat tacaccttgc     3120

agcttcggcg gtgttagtgt aatcacgccg ggcactaata catccaatca ggtcgctgtg     3180

ttgtaccaag atgttaactg tacggaggta cctgttgcaa tacatgcgga ccaactcact     3240

cctacttgga gggtatattc taccggatcc aacgtgttcc agactcgggc gggctgcctg     3300

ataggtgccg agcatgtcaa taattcttac gaatgcgata ttccaatagg ggccggcata     3360

tgtgcatctt atcaaaccca aaccaactcc ccctctggtg ggggaggctc aggcggaggt     3420

ggtagcgggg gcggtggttc atctgttgcg tcacagagta ttatagccta tacgatgtct     3480

ttgggggcgg aaaactccgt cgcttactcc aacaacagta tagcaatccc tacgaatttt     3540

accatctccg taacaactga aatccttcct gtgtcaatga ccaaaacttc tgtcgattgc     3600

acgatgtata tctgcggaga cagcacggaa tgtagtaact tgctcctcca gtacggctct     3660

ttctgcacac agctcaatcg ggcgctgacc gggatagcgg tggaacaaga caagaacacc     3720

caggaagtct tcgcgcaggt caagcaaatc tacaagaccc ctcccattaa agattttggt     3780

ggttttaact ttagccaaat actgccagat ccgtccaaat ctgggggtgg gggaagtggg     3840

ggagggggga gcggcggagg aggtagttcc ttcatcgagg acctcctttt taacaaagtt     3900

accctcgccg acgccgggtt cataaaacag tacggcgact gcttgggtga catcgcagcc     3960

agagacttga tttgtgcgca aaaattcaac ggccttacgg tcctgcctcc attgctgacc     4020

gatgaaatga ttgcccagta tacctctgct ttgttggcag ggacaataac ttctgggtgg     4080

acgtttggag caggcgctgc cctgcagatc ccttttgcca tgcagatggc ataccggttt     4140

aacgggatcg gtgttactca gaacgtactc tatgagaatc aaaagctgat cgccaaccaa     4200

tttaatagcg ccatcggtaa aatccaggat agtttgagca gcaccgcttc tgcacttggg     4260

aagcttcagg atgttgtgaa tcagaacgcc caagcattga atactctcgt caaacaattg     4320

agtagtaatt tcggagccat ctcatctgtg ttgaatgaca tactcagtcg cctcgataag     4380

gtagaggctg aggtgcagat agaccggctt ataactggta gattgcagag ccttcagact     4440

tacgtgacgc aacagcttat ccgagcagca gaaatcaggg catcagcaaa tcttgccgcc     4500

accaaaatgt cagagtgcgt actgggccaa agtaaaagag tggatttttg tggaaaagga     4560

taccacttga tgagctttcc ccagtctgcc ccgcacggtg tggtcttcct gcacgtaacc     4620

tacgtgccgg cgcaagaaaa aaactttacc accgctcccg cgatatgtca cgacggaaag     4680

gcgcattttc cgcgagaagg cgtatttgta tcaaacggaa cacactggtt cgttacccag     4740

cgaaacttct acgagccaca gatcattact acggataata cattcgtctc tggtaattgc     4800

gatgtagtca taggaatagt aaataatacg gtttatgacc ccctccaacc tgagcttgac     4860

tccttcaaag aggaacttga taaatacttt aagaatcata cctctccgga tgtcgatctc     4920

ggggatattt ctggtatcaa tgcaagcgtc gtgaacatac agaaagaaat cgacagattg     4980

aacgaagtcg cgaagaatct taacgaatct ctgatagact tgcaagaatt gggcaagtat     5040

gagcagggcg gccgctaccc atacgacgta ccagattacg cttaaagatc tttttccctc     5100

tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg gctaataaag     5160

gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctcac tcggaaggac     5220

atatgggagg gcaaatcatt taaaacatca gaatgagtat ttggtttaga gtttggcaac     5280

atatgcccat tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg     5340

gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa     5400

cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc     5460

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc     5520

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag     5580

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct     5640

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta     5700

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc     5760

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc     5820

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     5880

gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct     5940

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     6000

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     6060

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     6120

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     6180

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     6240

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     6300

actcgggggg ggggggcgct gaggtctgcc tcgtgaagaa ggtgttgctg actcatacca     6360

ggcctgaatc gccccatcat ccagccagaa agtgagggag ccacggttga tgagagcttt     6420

gttgtaggtg gaccagttgg tgattttgaa cttttgcttt gccacggaac ggtctgcgtt     6480

gtcgggaaga tgcgtgatct gatccttcaa ctcagcaaaa gttcgattta ttcaacaaag     6540

ccgccgtccc gtcaagtcag cgtaatgctc tgccagtgtt acaaccaatt aaccaattct     6600

gattagaaaa actcatcgag catcaaatga aactgcaatt tattcatatc aggattatca     6660

ataccatatt tttgaaaaag ccgtttctgt aatgaaggag aaaactcacc gaggcagttc     6720

cataggatgg caagatcctg gtatcggtct gcgattccga ctcgtccaac atcaatacaa     6780

cctattaatt tcccctcgtc aaaaataagg ttatcaagtg agaaatcacc atgagtgacg     6840

actgaatccg gtgagaatgg caaaagctta tgcatttctt tccagacttg ttcaacaggc     6900

cagccattac gctcgtcatc aaaatcactc gcatcaacca aaccgttatt cattcgtgat     6960

tgcgcctgag cgagacgaaa tacgcgatcg ctgttaaaag gacaattaca aacaggaatc     7020

gaatgcaacc ggcgcaggaa cactgccagc gcatcaacaa tattttcacc tgaatcagga     7080

tattcttcta atacctggaa tgctgttttc ccggggatcg cagtggtgag taaccatgca     7140

tcatcaggag tacggataaa atgcttgatg gtcggaagag gcataaattc cgtcagccag     7200

tttagtctga ccatctcatc tgtaacatca ttggcaacgc tacctttgcc atgtttcaga     7260

aacaactctg gcgcatcggg cttcccatac aatcgataga ttgtcgcacc tgattgcccg     7320

acattatcgc gagcccattt atacccatat aaatcagcat ccatgttgga atttaatcgc     7380

ggcctggagc aagacgtttc ccgttgaata tggctcataa caccccttgt attactgttt     7440

atgtaagcag acagttttat tgttcatgat gatatatttt tatcttgtgc aatgtaacat     7500

cagagatttt gagacacaac gtggctttcc cccccccccc attattgaag catttatcag     7560

ggttattgtc tcatgagcgg atacatattt gaatgtattt agaaaaataa acaaataggg     7620

gttccgcgca catttccccg aaaagtgcca cctgacgtct aagaaaccat tattatcatg     7680

acattaacct ataaaaatag gcgtatcacg aggccctttc gtctcgcgcg tttcggtgat     7740

gacggtgaaa acctctgaca catgcagctc ccggagacgg tcacagcttg tctgtaagcg     7800

gatgccggga gcagacaagc ccgtcagggc gcgtcagcgg gtgttggcgg gtgtcggggc     7860

tggcttaact atgcggcatc agagcagatt gtactgagag tgcaccatat gcggtgtgaa     7920

ataccgcaca gatgcgtaag gagaaaatac cgcatcagat tggctat                   7967


<210>  16
<211>  1336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser Asn Phe Asp Cys Cys 
            20                  25                  30          


Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly Phe 
        35                  40                  45              


Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile Phe 
    50                  55                  60                  


His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr Trp 
65                  70                  75                  80  


Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met Glu 
                85                  90                  95      


Phe Asn Asp Ala Gln Ala Pro Lys Ser Leu Glu Val Asn Leu Thr Thr 
            100                 105                 110         


Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val 
        115                 120                 125             


Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln 
    130                 135                 140                 


Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile 
145                 150                 155                 160 


His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu 
                165                 170                 175     


Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile 
            180                 185                 190         


Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser 
        195                 200                 205             


Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu 
    210                 215                 220                 


Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn 
225                 230                 235                 240 


Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn 
                245                 250                 255     


Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu 
            260                 265                 270         


Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn 
        275                 280                 285             


Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu 
    290                 295                 300                 


Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp 
305                 310                 315                 320 


Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu 
                325                 330                 335     


His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala 
            340                 345                 350         


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
        355                 360                 365             


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
    370                 375                 380                 


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
385                 390                 395                 400 


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
                405                 410                 415     


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
            420                 425                 430         


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
        435                 440                 445             


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
    450                 455                 460                 


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
465                 470                 475                 480 


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
                485                 490                 495     


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            500                 505                 510         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        515                 520                 525             


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu 
    530                 535                 540                 


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
545                 550                 555                 560 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
                565                 570                 575     


Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            580                 585                 590         


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
        595                 600                 605             


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
    610                 615                 620                 


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
625                 630                 635                 640 


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
                645                 650                 655     


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
            660                 665                 670         


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
        675                 680                 685             


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
    690                 695                 700                 


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
705                 710                 715                 720 


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
                725                 730                 735     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            740                 745                 750         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        755                 760                 765             


Gln Thr Asn Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    770                 775                 780                 


Gly Gly Gly Gly Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr 
785                 790                 795                 800 


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
                805                 810                 815     


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
            820                 825                 830         


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
        835                 840                 845             


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
    850                 855                 860                 


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
865                 870                 875                 880 


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
                885                 890                 895     


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
            900                 905                 910         


Pro Ser Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        915                 920                 925             


Gly Gly Ser Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
    930                 935                 940                 


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
945                 950                 955                 960 


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
                965                 970                 975     


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
            980                 985                 990         


Leu Leu Ala Gly Thr Ile Thr Ser  Gly Trp Thr Phe Gly  Ala Gly Ala 
        995                 1000                 1005             


Ala Leu  Gln Ile Pro Phe Ala  Met Gln Met Ala Tyr  Arg Phe Asn 
    1010                 1015                 1020             


Gly Ile  Gly Val Thr Gln Asn  Val Leu Tyr Glu Asn  Gln Lys Leu 
    1025                 1030                 1035             


Ile Ala  Asn Gln Phe Asn Ser  Ala Ile Gly Lys Ile  Gln Asp Ser 
    1040                 1045                 1050             


Leu Ser  Ser Thr Ala Ser Ala  Leu Gly Lys Leu Gln  Asp Val Val 
    1055                 1060                 1065             


Asn Gln  Asn Ala Gln Ala Leu  Asn Thr Leu Val Lys  Gln Leu Ser 
    1070                 1075                 1080             


Ser Asn  Phe Gly Ala Ile Ser  Ser Val Leu Asn Asp  Ile Leu Ser 
    1085                 1090                 1095             


Arg Leu  Asp Lys Val Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile 
    1100                 1105                 1110             


Thr Gly  Arg Leu Gln Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu 
    1115                 1120                 1125             


Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr 
    1130                 1135                 1140             


Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe 
    1145                 1150                 1155             


Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe Pro Gln  Ser Ala Pro 
    1160                 1165                 1170             


His Gly  Val Val Phe Leu His  Val Thr Tyr Val Pro  Ala Gln Glu 
    1175                 1180                 1185             


Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala 
    1190                 1195                 1200             


His Phe  Pro Arg Glu Gly Val  Phe Val Ser Asn Gly  Thr His Trp 
    1205                 1210                 1215             


Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr 
    1220                 1225                 1230             


Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile 
    1235                 1240                 1245             


Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser 
    1250                 1255                 1260             


Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro 
    1265                 1270                 1275             


Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val 
    1280                 1285                 1290             


Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn 
    1295                 1300                 1305             


Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu 
    1310                 1315                 1320             


Gln Gly  Gly Arg Tyr Pro Tyr  Asp Val Pro Asp Tyr  Ala 
    1325                 1330                 1335     


<210>  17
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ala Ser Asn Phe Asp Cys 
            20                  25                  30          


Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys Phe Ile Val Gly 
        35                  40                  45              


Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile Asn Ala Ile Ile 
    50                  55                  60                  


Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn Pro Lys Gln Thr 
65                  70                  75                  80  


Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys Val Lys Asn Met 
                85                  90                  95      


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys 
1               5                   10                  15  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Asp Ser Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr 
1               5                   10                  


<210>  20
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Arg Arg Ala Arg 
1               


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Pro Ser Lys Arg 
1               


<210>  22
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Gly Gly Gly Gly Ser 
1               5   


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Gly Gly Gly Ser 
1               


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  27
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10              


<210>  28
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
atgtgctgta ccaagagttt gctcctggct gctttgatgt cagtgctgct actccacctc       60

tgcggcgaat cagaagcaag c                                                 81


<210>  29
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Met Cys Cys Thr Lys Ser Leu Leu Leu Ala Ala Leu Met Ser Val Leu 
1               5                   10                  15      


Leu Leu His Leu Cys Gly Glu Ser Glu Ala Ser 
            20                  25          


<210>  30
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  30
tacccatacg acgtaccaga ttacgct                                           27


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  32
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  32
aacgacgctc aggcgccgaa gagt                                              24


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Asn Asp Ala Gln Ala Pro Lys Ser 
1               5               


<210>  34
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  34
cggcgggcac gt                                                           12


<210>  35
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  35
ccaagcaaga gg                                                           12


<210>  36
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  36
ggtgggggag gctcaggcgg aggtggtagc gggggcggtg gttca                       45


<210>  37
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  37
gggggtgggg gaagtggggg aggggggagc ggcggaggag gtagt                       45


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  40
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu 
1               5                   10                  15      


Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys 
            20                  25                  30          


Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe 
        35                  40                  45              


Asp Glu Asp Asp Ser Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr 
    50                  55                  60                  


Thr 
65  


<210>  41
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu 
1               5                   10                  15      


Ile Ala Ile Val Met Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys 
            20                  25                  30          


Cys Ser Cys Leu Lys Gly Cys Cys Ser Cys Gly Ser Cys Cys 
        35                  40                  45      


<210>  42
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Lys Phe Asp Glu Asp Asp Ser Glu Pro Val Leu Lys Gly Val Lys Leu 
1               5                   10                  15      


His Tyr Thr 
            


<210>  43
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Asn Phe Asp Cys Cys Leu Gly Tyr Thr Asp Arg Ile Leu His Pro Lys 
1               5                   10                  15      


Phe Ile Val Gly Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys Asp Ile 
            20                  25                  30          


Asn Ala Ile Ile Phe His Thr Lys Lys Lys Leu Ser Val Cys Ala Asn 
        35                  40                  45              


Pro Lys Gln Thr Trp Val Lys Tyr Ile Val Arg Leu Leu Ser Lys Lys 
    50                  55                  60                  


Val Lys Asn Met Glu Phe Asn Asp Ala Gln Ala Pro Lys Ser Leu Glu 
65                  70                  75                  80  


<210>  44
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  45
<211>  1258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1190                 1195                 1200             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1205                 1210                 1215             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1220                 1225                 1230             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1235                 1240                 1245             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1250                 1255             


<210>  46
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  46

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro 
            660                 665     


<210>  47
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
1               5                   10                  15      


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
            20                  25                  30          


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
        35                  40                  45              


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
    50                  55                  60                  


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
65                  70                  75                  80  


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
                85                  90                  95      


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
            100                 105                 110         


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
        115                 120                 125     


<210>  48
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  48

Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
1               5                   10                  15      


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            20                  25                  30          


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        35                  40                  45              


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    50                  55                  60                  


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
65                  70                  75                  80  


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                85                  90                  95      


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            100                 105                 110         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        115                 120                 125             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    130                 135                 140                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
145                 150                 155                 160 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                165                 170                 175     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            180                 185                 190         


Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
        195                 200                 205             


Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg 
    210                 215                 220                 


Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser 
225                 230                 235                 240 


Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln 
                245                 250                 255     


Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala 
            260                 265                 270         


His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe 
        275                 280                 285             


Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn 
    290                 295                 300                 


Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn 
305                 310                 315                 320 


Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu 
                325                 330                 335     


Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly 
            340                 345                 350         


Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile 
        355                 360                 365             


Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp 
    370                 375                 380                 


Leu Gln Glu Leu Gly Lys Tyr Glu Gln 
385                 390             


