                         SEQUENCE LISTING

<110>  Carina Biotech Pty Ltd.
 
<120>  CHIMERIC ANTIGEN RECEPTOR T CELL

<130>  1180203

<160>  104   

<170>  PatentIn version 3.5

<210>  1
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


<210>  2
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  3
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  4
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  4

Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr Pro Leu Gly Asp 
1               5                   10                  15      


Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr 
            20                  25                  30          


Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro 
        35                  40                  45              


Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro 
    50                  55                  60                  


Pro Cys Pro Arg Cys Pro 
65                  70  


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  6

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr 
1               5                   10                  15      


Pro Ser Pro Ser Cys 
            20      


<210>  8
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  9
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro Asp 
            100                 105                 110         


<210>  10
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Thr Val Lys Ile Leu Gln Ser Ser Cys Asp Gly Gly Gly His Phe 
1               5                   10                  15      


Pro Pro Thr Ile Gln Leu Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly 
            20                  25                  30          


Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly Gln Val Met Asp Val Asp 
        35                  40                  45              


Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln 
    50                  55                  60                  


Ser Glu Leu Thr Leu Ser Gln Lys His Trp Leu Ser Asp Arg Thr Tyr 
65                  70                  75                  80  


Thr Cys Gln Val Thr Tyr Gln Gly His Thr Phe Glu Asp Ser Thr Lys 
                85                  90                  95      


Lys Cys Ala 
            


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10                  15  


<210>  12
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
1               5                   10                  15      


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
            20                  25                  30          


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45              


<210>  13
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  14
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Val Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser 
1               5                   10                  15      


Thr Leu Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys 
            20                  25                  30          


Gly Pro Leu Cys Ser Pro 
        35              


<210>  15
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  15

Val Asp Phe Leu Pro Thr Thr Ala Gln Pro Thr Lys Lys Ser Thr Leu 
1               5                   10                  15      


Lys Lys Arg Val Cys Arg Leu Pro Arg Pro Glu Thr Gln Lys Gly Pro 
            20                  25                  30          


Leu Cys Ser Pro 
        35      


<210>  16
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Pro Pro Arg Ala Ser Ala Leu Pro Ala Pro Pro Thr Gly Ser Ala 
1               5                   10                  15      


Leu Pro Asp Pro Gln Thr Ala Ser Ala Leu Pro Asp Pro Pro Ala Ala 
            20                  25                  30          


Ser Ala Leu Pro 
        35      


<210>  17
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  17

Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile Lys Val Leu Pro Thr 
1               5                   10                  15      


Trp Ser Thr Pro Val Gln Pro 
            20              


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PolyG/S hinge

<400>  18

Gly Gly Gly Gly Ser 
1               5   


<210>  19
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  20
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  21
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  22
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  23
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  23

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  24
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  25
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  26
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  27
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 110 


<210>  28
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  29
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  30
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  31
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  32
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  33
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg 
            180 


<210>  34
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  35
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asp Thr Glu Ser Asn Arg Arg Ala Asn Leu Ala Leu Pro Gln Glu 
1               5                   10                  15      


Pro Ser Ser Val Pro Ala Phe Glu Val Leu Glu Ile Ser Pro Gln Glu 
            20                  25                  30          


Val Ser Ser Gly Arg Leu Leu Lys Ser Ala Ser Ser Pro Pro Leu His 
        35                  40                  45              


Thr Trp Leu Thr Val Leu Lys Lys Glu Gln Glu Phe Leu Gly Val Thr 
    50                  55                  60                  


Gln Ile Leu Thr Ala Met Ile Cys Leu Cys Phe Gly Thr Val Val Cys 
65                  70                  75                  80  


Ser Val Leu Asp Ile Ser His Ile Glu Gly Asp Ile Phe Ser Ser Phe 
                85                  90                  95      


Lys Ala Gly Tyr Pro Phe Trp Gly Ala Ile Phe Phe Ser Ile Ser Gly 
            100                 105                 110         


Met Leu Ser Ile Ile Ser Glu Arg Arg Asn Ala Thr Tyr Leu Val Arg 
        115                 120                 125             


Gly Ser Leu Gly Ala Asn Thr Ala Ser Ser Ile Ala Gly Gly Thr Gly 
    130                 135                 140                 


Ile Thr Ile Leu Ile Ile Asn Leu Lys Lys Ser Leu Ala Tyr Ile His 
145                 150                 155                 160 


Ile His Ser Cys Gln Lys Phe Phe Glu Thr Lys Cys Phe Met Ala Ser 
                165                 170                 175     


Phe Ser Thr Glu Ile Val Val Met Met Leu Phe Leu Thr Ile Leu Gly 
            180                 185                 190         


Leu Gly Ser Ala Val Ser Leu Thr Ile Cys Gly Ala Gly Glu Glu Leu 
        195                 200                 205             


Lys Gly Asn Lys Val Pro Glu Asp Arg Val Tyr Glu Glu Leu Asn Ile 
    210                 215                 220                 


Tyr Ser Ala Thr Tyr Ser Glu Leu Glu Asp Pro Gly Glu Met Ser Pro 
225                 230                 235                 240 


Pro Ile Asp Leu 
                


<210>  36
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Val Leu Phe Tyr Leu Ala Val Gly Ile Met Phe Leu 
    290                 295                 300                 


Val Asn Thr Val Leu Trp Val Thr Ile Arg Lys Glu Leu Lys Arg Lys 
305                 310                 315                 320 


Lys Lys Trp Asp Leu Glu Ile Ser Leu Asp Ser Gly His Glu Lys Lys 
                325                 330                 335     


Val Ile Ser Ser Leu Gln Glu Asp Arg His Leu Glu Glu Glu Leu Lys 
            340                 345                 350         


Cys Gln Glu Gln Lys Glu Glu Gln Leu Gln Glu Gly Val His Arg Lys 
        355                 360                 365             


Glu Pro Gln Gly Ala Thr 
    370                 


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR VH CDR1

<400>  37

Gly Tyr Ser Phe Thr Ala Tyr Trp 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR VH CDR2

<400>  38

Ile Leu Pro Gly Ser Asp Ser Thr 
1               5               


<210>  39
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR VH CDR3

<400>  39

Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr 
1               5                   10      


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR VL CDR1

<400>  40

Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe 
1               5                   10  


<210>  41
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR VL CDR2

<400>  41

Leu Thr Ser 
1           


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR VL CDR3

<400>  42

Gln Gln Asn Ala Glu Asp Pro Arg Thr 
1               5                   


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR VH CDR1 encoding DNA

<400>  43
ggctattcat tcactgctta ctgg                                              24


<210>  44
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR VH CDR2 encoding DNA

<400>  44
atacttccgg gatccgactc cact                                              24


<210>  45
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR VH CDR3 encoding DNA

<400>  45
gcccgcagcg ggctgtacgg gtcaagtcaa tat                                    33


<210>  46
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR VL CDR1 encoding DNA

<400>  46
gagtctgtag actcctacgg gaatagtttt                                        30


<210>  47
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR VL CDR2 encoding DNA

<400>  47
cttacttcc                                                                9


<210>  48
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR VL CDR3 encoding DNA

<400>  48
caacagaatg ctgaggaccc acgaact                                           27


<210>  49
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct Variable Light Chain

<400>  49

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  50
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct Variable Heavy Chain

<400>  50

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  51
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR DNA Construct Variable Light Chain 30xx

<400>  51
gacatagttc tcacccaatc tccggcgtct ctggccgtgt cacccggcca aagagctacc       60

attacgtgta gggcgtcaga gtctgtagac tcctacggga atagttttat gcactggtac      120

cagcagaaac cgggtcagcc gcccaaactt ctgatctatc ttacttccaa tctcgagtct      180

ggcgtgcccg ataggttttc aggatcagga tctggtaccg actttacact gaccattaat      240

ccagtcgaag cgaacgacgc cgcaacatac tattgccaac agaatgctga ggacccacga      300

acttttggag gagggacaaa attggagatc aag                                   333


<210>  52
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR DNA Construct Variable Heavy Chain DNA 30xx

<400>  52
gaggtgcaac tcgttcaaag cggtgccgag gtaaagaagc caggcgagag tctcagaatt       60

agctgtaaag gctcaggcta ttcattcact gcttactgga tcgaatgggt tcgccaggcg      120

ccaggtaagg gcctcgaatg gattggtgag atacttccgg gatccgactc cactaattat      180

aacgaaaaat tcaaagggca cgtgacgatc tccgccgata agagtatctc aactgcgtac      240

ttgcagtggt catcattgaa ggcgagcgac acggccgtgt attattgcgc ccgcagcggg      300

ctgtacgggt caagtcaata ttggggacag gggactcttg tcacggtttc aagc            354


<210>  53
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct Binding Domain CNA30xx-Variable Light-Variable 
       Heavy

<400>  53

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
    130                 135                 140                 


Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ala 
145                 150                 155                 160 


Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  54
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct Binding Domain CNA31xx-Variable Heavy-Variable 
       Light

<400>  54

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly 
        115                 120                 125             


Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser 
            180                 185                 190         


Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct IgG4 mutant hinge linker

<400>  55

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  56
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct hinge-CH3 linker

<400>  56

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg 
1               5                   10                  15      


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
            20                  25                  30          


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        35                  40                  45              


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    50                  55                  60                  


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
65                  70                  75                  80  


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
                85                  90                  95      


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            100                 105                 110         


Leu Ser Leu Ser Leu Gly Lys 
        115                 


<210>  57
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct hinge-CH2-CH3 linker

<400>  57

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Asp Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  58
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CD3 Zeta signalling domain

<400>  58

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110     


<210>  59
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct 4-1BB Signalling Domain

<400>  59

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  60
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA3002

<400>  60

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn 
        195                 200                 205             


Tyr Asn Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser 
    210                 215                 220                 


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly 
        275                 280                 285             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    290                 295                 300                 


Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
305                 310                 315                 320 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                325                 330                 335     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            340                 345                 350         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        355                 360                 365             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    370                 375                 380                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
385                 390                 395                 400 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                405                 410                 415     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            420                 425                 430         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        435                 440                 445             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 460 


<210>  61
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA3003

<400>  61

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn 
        195                 200                 205             


Tyr Asn Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser 
    210                 215                 220                 


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        275                 280                 285             


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
    290                 295                 300                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
305                 310                 315                 320 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                325                 330                 335     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
            340                 345                 350         


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
        355                 360                 365             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
    370                 375                 380                 


Gly Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
385                 390                 395                 400 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
                405                 410                 415     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            420                 425                 430         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        435                 440                 445             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    450                 455                 460                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
465                 470                 475                 480 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                485                 490                 495     


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
            500                 505                 510         


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
        515                 520                 525             


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
    530                 535                 540                 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
545                 550                 555                 560 


His Met Gln Ala Leu Pro Pro 
                565         


<210>  62
<211>  677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA3004

<400>  62

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Tyr Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asn Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Ala Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr 
                165                 170                 175     


Ser Phe Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn 
        195                 200                 205             


Tyr Asn Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser 
    210                 215                 220                 


Ile Ser Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Asp Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
305                 310                 315                 320 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                485                 490                 495     


Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            500                 505                 510         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg 
        515                 520                 525             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    530                 535                 540                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
545                 550                 555                 560 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                565                 570                 575     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            580                 585                 590         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        595                 600                 605             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    610                 615                 620                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
625                 630                 635                 640 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                645                 650                 655     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            660                 665                 670         


Gln Ala Leu Pro Pro 
        675         


<210>  63
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA3102

<400>  63

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
    130                 135                 140                 


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Pro Arg Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Met Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    450                 455                 


<210>  64
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA3103

<400>  64

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
    130                 135                 140                 


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Pro Arg Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        275                 280                 285             


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    290                 295                 300                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
305                 310                 315                 320 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                325                 330                 335     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
            340                 345                 350         


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        355                 360                 365             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
    370                 375                 380                 


Lys Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
385                 390                 395                 400 


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
                405                 410                 415     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            420                 425                 430         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        435                 440                 445             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    450                 455                 460                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
465                 470                 475                 480 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                485                 490                 495     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            500                 505                 510         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        515                 520                 525             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    530                 535                 540                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
545                 550                 555                 560 


Met Gln Ala Leu Pro Pro 
                565     


<210>  65
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA3104

<400>  65

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Ala Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Gly Leu Tyr Gly Ser Ser Gln Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr Ser Gly Ser Gly 
    130                 135                 140                 


Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Val Leu Thr 
145                 150                 155                 160 


Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr Ile 
                165                 170                 175     


Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met 
            180                 185                 190         


His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala Asn 
225                 230                 235                 240 


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Pro Arg Thr 
                245                 250                 255     


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Ser Lys Tyr Gly Pro 
            260                 265                 270         


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Asp Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
305                 310                 315                 320 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Met 
                485                 490                 495     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            500                 505                 510         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys 
        515                 520                 525             


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
    530                 535                 540                 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
545                 550                 555                 560 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
                565                 570                 575     


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
            580                 585                 590         


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
        595                 600                 605             


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
    610                 615                 620                 


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
625                 630                 635                 640 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
                645                 650                 655     


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
            660                 665                 670         


Ala Leu Pro Pro 
        675     


<210>  66
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct encoding DNA CNA3002

<400>  66
atgtccgttc ccactcaagt ccttggactt ttgctgcttt ggctgaccga cgctcgatgc       60

gacatagttc tcacccaatc tccggcgtct ctggccgtgt cacccggcca aagagctacc      120

attacgtgta gggcgtcaga gtctgtagac tcctacggga atagttttat gcactggtac      180

cagcagaaac cgggtcagcc gcccaaactt ctgatctatc ttacttccaa tctcgagtct      240

ggcgtgcccg ataggttttc aggatcagga tctggtaccg actttacact gaccattaat      300

ccagtcgaag cgaacgacgc cgcaacatac tattgccaac agaatgctga ggacccacga      360

acttttggag gagggacaaa attggagatc aagggtagca cgagtggttc tggaaagccg      420

ggtagtggtg aggggagcac gaaaggagag gtgcaactcg ttcaaagcgg tgccgaggta      480

aagaagccag gcgagagtct cagaattagc tgtaaaggct caggctattc attcactgct      540

tactggatcg aatgggttcg ccaggcgcca ggtaagggcc tcgaatggat tggtgagata      600

cttccgggat ccgactccac taattataac gaaaaattca aagggcacgt gacgatctcc      660

gccgataaga gtatctcaac tgcgtacttg cagtggtcat cattgaaggc gagcgacacg      720

gccgtgtatt attgcgcccg cagcgggctg tacgggtcaa gtcaatattg gggacagggg      780

actcttgtca cggtttcaag cgaatccaag tacggaccgc cctgcccccc ttgccctatg      840

ttctgggtgc tggtggtggt cggaggcgtg ctggcctgct acagcctgct ggtcaccgtg      900

gccttcatca tcttttgggt gaaacggggc agaaagaaac tcctgtatat attcaaacaa      960

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca     1020

gaagaagaag aaggaggatg tgaactgcgg gtgaagttca gcagaagcgc cgacgcccct     1080

gcctaccagc agggccagaa tcagctgtac aacgagctga acctgggcag aagggaagag     1140

tacgacgtcc tggataagcg gagaggccgg gaccctgaga tgggcggcaa gcctcggcgg     1200

aagaaccccc aggaaggcct gtataacgaa ctgcagaaag acaagatggc cgaggcctac     1260

agcgagatcg gcatgaaggg cgagcggagg cggggcaagg gccacgacgg cctgtatcag     1320

ggcctgtcca ccgccaccaa ggatacctac gacgccctgc acatgcaggc cctgccccca     1380


<210>  67
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct encoding DNA CNA3003

<400>  67
atgtccgttc ccactcaagt ccttggactt ttgctgcttt ggctgaccga cgctcgatgc       60

gacatagttc tcacccaatc tccggcgtct ctggccgtgt cacccggcca aagagctacc      120

attacgtgta gggcgtcaga gtctgtagac tcctacggga atagttttat gcactggtac      180

cagcagaaac cgggtcagcc gcccaaactt ctgatctatc ttacttccaa tctcgagtct      240

ggcgtgcccg ataggttttc aggatcagga tctggtaccg actttacact gaccattaat      300

ccagtcgaag cgaacgacgc cgcaacatac tattgccaac agaatgctga ggacccacga      360

acttttggag gagggacaaa attggagatc aagggtagca cgagtggttc tggaaagccg      420

ggtagtggtg aggggagcac gaaaggagag gtgcaactcg ttcaaagcgg tgccgaggta      480

aagaagccag gcgagagtct cagaattagc tgtaaaggct caggctattc attcactgct      540

tactggatcg aatgggttcg ccaggcgcca ggtaagggcc tcgaatggat tggtgagata      600

cttccgggat ccgactccac taattataac gaaaaattca aagggcacgt gacgatctcc      660

gccgataaga gtatctcaac tgcgtacttg cagtggtcat cattgaaggc gagcgacacg      720

gccgtgtatt attgcgcccg cagcgggctg tacgggtcaa gtcaatattg gggacagggg      780

actcttgtca cggtttcaag cgaatccaag tacggaccgc cctgcccccc ttgccctggc      840

cagcctagag aaccccaggt gtacaccctg cctcccagcc aggaagagat gaccaagaac      900

caggtgtccc tgacctgcct ggtcaaaggc ttctacccca gcgatatcgc cgtggaatgg      960

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac     1020

ggcagcttct tcctgtactc ccggctgacc gtggacaaga gccggtggca ggaaggcaac     1080

gtcttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1140

agcctgagcc tgggcaagat gttctgggtg ctggtggtgg tcggaggcgt gctggcctgc     1200

tacagcctgc tggtcaccgt ggccttcatc atcttttggg tgaaacgggg cagaaagaaa     1260

ctcctgtata tattcaaaca accatttatg agaccagtac aaactactca agaggaagat     1320

ggctgtagct gccgatttcc agaagaagaa gaaggaggat gtgaactgcg ggtgaagttc     1380

agcagaagcg ccgacgcccc tgcctaccag cagggccaga atcagctgta caacgagctg     1440

aacctgggca gaagggaaga gtacgacgtc ctggataagc ggagaggccg ggaccctgag     1500

atgggcggca agcctcggcg gaagaacccc caggaaggcc tgtataacga actgcagaaa     1560

gacaagatgg ccgaggccta cagcgagatc ggcatgaagg gcgagcggag gcggggcaag     1620

ggccacgacg gcctgtatca gggcctgtcc accgccacca aggataccta cgacgccctg     1680

cacatgcagg ccctgccccc a                                               1701


<210>  68
<211>  2031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct encoding DNA CNA3004

<400>  68
atgtccgttc ccactcaagt ccttggactt ttgctgcttt ggctgaccga cgctcgatgc       60

gacatagttc tcacccaatc tccggcgtct ctggccgtgt cacccggcca aagagctacc      120

attacgtgta gggcgtcaga gtctgtagac tcctacggga atagttttat gcactggtac      180

cagcagaaac cgggtcagcc gcccaaactt ctgatctatc ttacttccaa tctcgagtct      240

ggcgtgcccg ataggttttc aggatcagga tctggtaccg actttacact gaccattaat      300

ccagtcgaag cgaacgacgc cgcaacatac tattgccaac agaatgctga ggacccacga      360

acttttggag gagggacaaa attggagatc aagggtagca cgagtggttc tggaaagccg      420

ggtagtggtg aggggagcac gaaaggagag gtgcaactcg ttcaaagcgg tgccgaggta      480

aagaagccag gcgagagtct cagaattagc tgtaaaggct caggctattc attcactgct      540

tactggatcg aatgggttcg ccaggcgcca ggtaagggcc tcgaatggat tggtgagata      600

cttccgggat ccgactccac taattataac gaaaaattca aagggcacgt gacgatctcc      660

gccgataaga gtatctcaac tgcgtacttg cagtggtcat cattgaaggc gagcgacacg      720

gccgtgtatt attgcgcccg cagcgggctg tacgggtcaa gtcaatattg gggacagggg      780

actcttgtca cggtttcaag cgaatccaag tacggaccgc cctgcccccc ttgccctgcc      840

cccgagttcg acggcggacc cagcgtgttc ctgttccccc ccaagcccaa ggacaccctg      900

atgatcagcc ggacccccga ggtgacctgc gtggtggtgg acgtgagcca ggaagatccc      960

gaggtccagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagccc     1020

agagaggaac agttccagag cacctaccgg gtggtgtctg tgctgaccgt gctgcaccag     1080

gactggctga acggcaaaga atacaagtgc aaggtgtcca acaagggcct gcccagcagc     1140

atcgaaaaga ccatcagcaa ggccaagggc cagcctcgcg agccccaggt gtacaccctg     1200

cctccctccc aggaagagat gaccaagaac caggtgtccc tgacctgcct ggtgaagggc     1260

ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac     1320

aagaccaccc ctcccgtgct ggacagcgac ggcagcttct tcctgtacag ccggctgacc     1380

gtggacaaga gccggtggca ggaaggcaac gtctttagct gcagcgtgat gcacgaggcc     1440

ctgcacaacc actacaccca gaagagcctg agcctgtccc tgggcaagat gttctgggtg     1500

ctggtggtgg tgggcggggt gctggcctgc tacagcctgc tggtgacagt ggccttcatc     1560

atcttttggg tgaaacgggg cagaaagaaa ctcctgtata tattcaaaca accatttatg     1620

agaccagtac aaactactca agaggaagat ggctgtagct gccgatttcc agaagaagaa     1680

gaaggaggat gtgaactgcg ggtgaagttc agcagaagcg ccgacgcccc tgcctaccag     1740

cagggccaga atcagctgta caacgagctg aacctgggca gaagggaaga gtacgacgtc     1800

ctggataagc ggagaggccg ggaccctgag atgggcggca agcctcggcg gaagaacccc     1860

caggaaggcc tgtataacga actgcagaaa gacaagatgg ccgaggccta cagcgagatc     1920

ggcatgaagg gcgagcggag gcggggcaag ggccacgacg gcctgtatca gggcctgtcc     1980

accgccacca aggataccta cgacgccctg cacatgcagg ccctgccccc a              2031


<210>  69
<211>  1377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct encoding DNA CNA3102

<400>  69
atggaatgga gctgggtttt cctctttttt ctttctgtca ccaccggggt gcattctgaa       60

gtgcagttgg ttcagtccgg tgcggaggta aaaaagccgg gagaatcact tcggattagt      120

tgcaaaggat cagggtatag tttcaccgcg tactggattg agtgggtgag acaggcgcca      180

gggaagggcc ttgaatggat tggtgagatc cttccgggct cagattccac gaactataac      240

gagaaattta agggtcatgt tactatctca gcagataaaa gcatcagtac ggcatatctt      300

cagtggtcca gtctgaaggc cagtgacacg gctgtgtact attgcgcccg ctctggtctc      360

tacggtagtt ctcaatactg gggccagggt acactcgtca ccgtatcttc cgggtccact      420

tcagggtccg gcaagcctgg gagtggtgag ggatccacta agggggatat cgtactgacc      480

caaagtccag catctctggc agtgtcacca gggcaaagag ctactattac ttgtagagct      540

tccgagtccg tggacagcta tggcaactcc ttcatgcatt ggtatcaaca aaaaccagga      600

caaccaccta agttgctcat ctacttgacc agcaacttgg aatcaggggt tccagaccgg      660

ttctctgggt ccggctccgg aacggatttt actcttacca taaacccggt ggaggcaaac      720

gatgctgcaa catactactg tcaacaaaac gccgaggatc cccgaacatt cggcggtgga      780

acgaagttgg aaattaagga gtcaaagtac ggaccgccct gccccccttg ccctatgttc      840

tgggtgctgg tggtggtcgg aggcgtgctg gcctgctaca gcctgctggt caccgtggcc      900

ttcatcatct tttgggtgaa acggggcaga aagaaactcc tgtatatatt caaacaacca      960

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1020

gaagaagaag gaggatgtga actgcgggtg aagttcagca gaagcgccga cgcccctgcc     1080

taccagcagg gccagaatca gctgtacaac gagctgaacc tgggcagaag ggaagagtac     1140

gacgtcctgg ataagcggag aggccgggac cctgagatgg gcggcaagcc tcggcggaag     1200

aacccccagg aaggcctgta taacgaactg cagaaagaca agatggccga ggcctacagc     1260

gagatcggca tgaagggcga gcggaggcgg ggcaagggcc acgacggcct gtatcagggc     1320

ctgtccaccg ccaccaagga tacctacgac gccctgcaca tgcaggccct gccccca        1377


<210>  70
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct encoding DNA CNA3103

<400>  70
atggaatgga gctgggtttt cctctttttt ctttctgtca ccaccggggt gcattctgaa       60

gtgcagttgg ttcagtccgg tgcggaggta aaaaagccgg gagaatcact tcggattagt      120

tgcaaaggat cagggtatag tttcaccgcg tactggattg agtgggtgag acaggcgcca      180

gggaagggcc ttgaatggat tggtgagatc cttccgggct cagattccac gaactataac      240

gagaaattta agggtcatgt tactatctca gcagataaaa gcatcagtac ggcatatctt      300

cagtggtcca gtctgaaggc cagtgacacg gctgtgtact attgcgcccg ctctggtctc      360

tacggtagtt ctcaatactg gggccagggt acactcgtca ccgtatcttc cgggtccact      420

tcagggtccg gcaagcctgg gagtggtgag ggatccacta agggggatat cgtactgacc      480

caaagtccag catctctggc agtgtcacca gggcaaagag ctactattac ttgtagagct      540

tccgagtccg tggacagcta tggcaactcc ttcatgcatt ggtatcaaca aaaaccagga      600

caaccaccta agttgctcat ctacttgacc agcaacttgg aatcaggggt tccagaccgg      660

ttctctgggt ccggctccgg aacggatttt actcttacca taaacccggt ggaggcaaac      720

gatgctgcaa catactactg tcaacaaaac gccgaggatc cccgaacatt cggcggtgga      780

acgaagttgg aaattaagga gtcaaagtac ggaccgccct gccccccttg ccctggccag      840

cctagagaac cccaggtgta caccctgcct cccagccagg aagagatgac caagaaccag      900

gtgtccctga cctgcctggt caaaggcttc taccccagcg atatcgccgt ggaatgggag      960

agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1020

agcttcttcc tgtactcccg gctgaccgtg gacaagagcc ggtggcagga aggcaacgtc     1080

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgagc     1140

ctgagcctgg gcaagatgtt ctgggtgctg gtggtggtcg gaggcgtgct ggcctgctac     1200

agcctgctgg tcaccgtggc cttcatcatc ttttgggtga aacggggcag aaagaaactc     1260

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     1320

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgcgggt gaagttcagc     1380

agaagcgccg acgcccctgc ctaccagcag ggccagaatc agctgtacaa cgagctgaac     1440

ctgggcagaa gggaagagta cgacgtcctg gataagcgga gaggccggga ccctgagatg     1500

ggcggcaagc ctcggcggaa gaacccccag gaaggcctgt ataacgaact gcagaaagac     1560

aagatggccg aggcctacag cgagatcggc atgaagggcg agcggaggcg gggcaagggc     1620

cacgacggcc tgtatcaggg cctgtccacc gccaccaagg atacctacga cgccctgcac     1680

atgcaggccc tgccccca                                                   1698


<210>  71
<211>  2028
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct encoding DNA CNA3104

<400>  71
atggaatgga gctgggtttt cctctttttt ctttctgtca ccaccggggt gcattctgaa       60

gtgcagttgg ttcagtccgg tgcggaggta aaaaagccgg gagaatcact tcggattagt      120

tgcaaaggat cagggtatag tttcaccgcg tactggattg agtgggtgag acaggcgcca      180

gggaagggcc ttgaatggat tggtgagatc cttccgggct cagattccac gaactataac      240

gagaaattta agggtcatgt tactatctca gcagataaaa gcatcagtac ggcatatctt      300

cagtggtcca gtctgaaggc cagtgacacg gctgtgtact attgcgcccg ctctggtctc      360

tacggtagtt ctcaatactg gggccagggt acactcgtca ccgtatcttc cgggtccact      420

tcagggtccg gcaagcctgg gagtggtgag ggatccacta agggggatat cgtactgacc      480

caaagtccag catctctggc agtgtcacca gggcaaagag ctactattac ttgtagagct      540

tccgagtccg tggacagcta tggcaactcc ttcatgcatt ggtatcaaca aaaaccagga      600

caaccaccta agttgctcat ctacttgacc agcaacttgg aatcaggggt tccagaccgg      660

ttctctgggt ccggctccgg aacggatttt actcttacca taaacccggt ggaggcaaac      720

gatgctgcaa catactactg tcaacaaaac gccgaggatc cccgaacatt cggcggtgga      780

acgaagttgg aaattaagga gtcaaagtac ggaccgccct gccccccttg ccctgccccc      840

gagttcgacg gcggacccag cgtgttcctg ttccccccca agcccaagga caccctgatg      900

atcagccgga cccccgaggt gacctgcgtg gtggtggacg tgagccagga agatcccgag      960

gtccagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga     1020

gaggaacagt tccagagcac ctaccgggtg gtgtctgtgc tgaccgtgct gcaccaggac     1080

tggctgaacg gcaaagaata caagtgcaag gtgtccaaca agggcctgcc cagcagcatc     1140

gaaaagacca tcagcaaggc caagggccag cctcgcgagc cccaggtgta caccctgcct     1200

ccctcccagg aagagatgac caagaaccag gtgtccctga cctgcctggt gaagggcttc     1260

taccccagcg acatcgccgt ggagtgggag agcaacggcc agcctgagaa caactacaag     1320

accacccctc ccgtgctgga cagcgacggc agcttcttcc tgtacagccg gctgaccgtg     1380

gacaagagcc ggtggcagga aggcaacgtc tttagctgca gcgtgatgca cgaggccctg     1440

cacaaccact acacccagaa gagcctgagc ctgtccctgg gcaagatgtt ctgggtgctg     1500

gtggtggtgg gcggggtgct ggcctgctac agcctgctgg tgacagtggc cttcatcatc     1560

ttttgggtga aacggggcag aaagaaactc ctgtatatat tcaaacaacc atttatgaga     1620

ccagtacaaa ctactcaaga ggaagatggc tgtagctgcc gatttccaga agaagaagaa     1680

ggaggatgtg aactgcgggt gaagttcagc agaagcgccg acgcccctgc ctaccagcag     1740

ggccagaatc agctgtacaa cgagctgaac ctgggcagaa gggaagagta cgacgtcctg     1800

gataagcgga gaggccggga ccctgagatg ggcggcaagc ctcggcggaa gaacccccag     1860

gaaggcctgt ataacgaact gcagaaagac aagatggccg aggcctacag cgagatcggc     1920

atgaagggcg agcggaggcg gggcaagggc cacgacggcc tgtatcaggg cctgtccacc     1980

gccaccaagg atacctacga cgccctgcac atgcaggccc tgccccca                  2028


<210>  72
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct CD28 trans membrane domain

<400>  72

Met Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
1               5                   10                  15      


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25              


<210>  73
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct ScFv CNA30xx - Variable Light-Variable Heavy DNA

<400>  73
gacatagttc tcacccaatc tccggcgtct ctggccgtgt cacccggcca aagagctacc       60

attacgtgta gggcgtcaga gtctgtagac tcctacggga atagttttat gcactggtac      120

cagcagaaac cgggtcagcc gcccaaactt ctgatctatc ttacttccaa tctcgagtct      180

ggcgtgcccg ataggttttc aggatcagga tctggtaccg actttacact gaccattaat      240

ccagtcgaag cgaacgacgc cgcaacatac tattgccaac agaatgctga ggacccacga      300

acttttggag gagggacaaa attggagatc aagggtagca cgagtggttc tggaaagccg      360

ggtagtggtg aggggagcac gaaaggagag gtgcaactcg ttcaaagcgg tgccgaggta      420

aagaagccag gcgagagtct cagaattagc tgtaaaggct caggctattc attcactgct      480

tactggatcg aatgggttcg ccaggcgcca ggtaagggcc tcgaatggat tggtgagata      540

cttccgggat ccgactccac taattataac gaaaaattca aagggcacgt gacgatctcc      600

gccgataaga gtatctcaac tgcgtacttg cagtggtcat cattgaaggc gagcgacacg      660

gccgtgtatt attgcgcccg cagcgggctg tacgggtcaa gtcaatattg gggacagggg      720

actcttgtca cggtttcaag c                                                741


<210>  74
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct ScFv CNA31xx - Variable Heavy-Variable Light DNA

<400>  74
gaagtgcagt tggttcagtc cggtgcggag gtaaaaaagc cgggagaatc acttcggatt       60

agttgcaaag gatcagggta tagtttcacc gcgtactgga ttgagtgggt gagacaggcg      120

ccagggaagg gccttgaatg gattggtgag atccttccgg gctcagattc cacgaactat      180

aacgagaaat ttaagggtca tgttactatc tcagcagata aaagcatcag tacggcatat      240

cttcagtggt ccagtctgaa ggccagtgac acggctgtgt actattgcgc ccgctctggt      300

ctctacggta gttctcaata ctggggccag ggtacactcg tcaccgtatc ttccgggtcc      360

acttcagggt ccggcaagcc tgggagtggt gagggatcca ctaaggggga tatcgtactg      420

acccaaagtc cagcatctct ggcagtgtca ccagggcaaa gagctactat tacttgtaga      480

gcttccgagt ccgtggacag ctatggcaac tccttcatgc attggtatca acaaaaacca      540

ggacaaccac ctaagttgct catctacttg accagcaact tggaatcagg ggttccagac      600

cggttctctg ggtccggctc cggaacggat tttactctta ccataaaccc ggtggaggca      660

aacgatgctg caacatacta ctgtcaacaa aacgccgagg atccccgaac attcggcggt      720

ggaacgaagt tggaaattaa g                                                741


<210>  75
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA30xx -IgG4 mutant hinge linker DNA

<400>  75
gaatccaagt acggaccgcc ctgcccccct tgccct                                 36


<210>  76
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA30xx -hinge-CH3 linker DNA

<400>  76
gaatccaagt acggaccgcc ctgcccccct tgccctggcc agcctagaga accccaggtg       60

tacaccctgc ctcccagcca ggaagagatg accaagaacc aggtgtccct gacctgcctg      120

gtcaaaggct tctaccccag cgatatcgcc gtggaatggg agagcaacgg ccagcccgag      180

aacaactaca agaccacccc ccctgtgctg gacagcgacg gcagcttctt cctgtactcc      240

cggctgaccg tggacaagag ccggtggcag gaaggcaacg tcttcagctg cagcgtgatg      300

cacgaggccc tgcacaacca ctacacccag aagtccctga gcctgagcct gggcaag         357


<210>  77
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA30xx -hinge-CH2-CH3 linker DNA

<400>  77
gaatccaagt acggaccgcc ctgcccccct tgccctgccc ccgagttcga cggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgcg tggtggtgga cgtgagccag gaagatcccg aggtccagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttccagagc      240

acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa      300

tacaagtgca aggtgtccaa caagggcctg cccagcagca tcgaaaagac catcagcaag      360

gccaagggcc agcctcgcga gccccaggtg tacaccctgc ctccctccca ggaagagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gaaggcaacg tctttagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaag                                          687


<210>  78
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct CD3 Zeta signalling domain DNA

<400>  78
cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg       60

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc      120

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc      300

tacgacgccc tgcacatgca ggccctgccc cca                                   333


<210>  79
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct T2A self-cleavage site

<400>  79

Arg Leu Glu Gly Gly Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly 
1               5                   10                  15      


Asp Val Glu Glu Asn Pro Gly Pro Arg 
            20                  25  


<210>  80
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct T2A self-cleavage site DNA

<400>  80
cgggtgaagt tcagcagaag cgccgacgcc cctgcctacc agcagggcca gaatcagctg       60

tacaacgagc tgaacctggg cagaagggaa gagtacgacg tcctggataa gcggagaggc      120

cgggaccctg agatgggcgg caagcctcgg cggaagaacc cccaggaagg cctgtataac      180

gaactgcaga aagacaagat ggccgaggcc tacagcgaga tcggcatgaa gggcgagcgg      240

aggcggggca agggccacga cggcctgtat cagggcctgt ccaccgccac caaggatacc      300

tacgacgccc tgcacatgca ggccctgccc cca                                   333


<210>  81
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct EGFRt

<400>  81

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Arg Lys Val Cys Asn Gly Ile Gly Ile Gly 
            20                  25                  30          


Glu Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe 
        35                  40                  45              


Lys Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala 
    50                  55                  60                  


Phe Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu 
65                  70                  75                  80  


Leu Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile 
                85                  90                  95      


Gln Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu 
            100                 105                 110         


Glu Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala 
        115                 120                 125             


Val Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu 
    130                 135                 140                 


Ile Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr 
145                 150                 155                 160 


Ala Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys 
                165                 170                 175     


Thr Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly 
            180                 185                 190         


Gln Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu 
        195                 200                 205             


Pro Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys 
    210                 215                 220                 


Val Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu 
225                 230                 235                 240 


Asn Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met 
                245                 250                 255     


Asn Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala 
            260                 265                 270         


His Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val 
        275                 280                 285             


Met Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His 
    290                 295                 300                 


Val Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro 
305                 310                 315                 320 


Gly Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala 
                325                 330                 335     


Thr Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly 
            340                 345                 350         


Ile Gly Leu Phe Met 
        355         


<210>  82
<211>  1074
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct EGFRt DNA

<400>  82
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg       60

atcccacgca aagtgtgtaa cggaataggt attggtgaat ttaaagactc actctccata      120

aatgctacga atattaaaca cttcaaaaac tgcacctcca tcagtggcga tctccacatc      180

ctgccggtgg catttagggg tgactccttc acacatactc ctcctctgga tccacaggaa      240

ctggatattc tgaaaaccgt aaaggaaatc acagggtttt tgctgattca ggcttggcct      300

gaaaacagga cggacctcca tgcctttgag aacctagaaa tcatacgcgg caggaccaag      360

caacatggtc agttttctct tgcagtcgtc agcctgaaca taacatcctt gggattacgc      420

tccctcaagg agataagtga tggagatgtg ataatttcag gaaacaaaaa tttgtgctat      480

gcaaatacaa taaactggaa aaaactgttt gggacctccg gtcagaaaac caaaattata      540

agcaacagag gtgaaaacag ctgcaaggcc acaggccagg tctgccatgc cttgtgctcc      600

cccgagggct gctggggccc ggagcccagg gactgcgtct cttgccggaa tgtcagccga      660

ggcagggaat gcgtggacaa gtgcaacctt ctggagggtg agccaaggga gtttgtggag      720

aactctgagt gcatacagtg ccacccagag tgcctgcctc aggccatgaa catcacctgc      780

acaggacggg gaccagacaa ctgtatccag tgtgcccact acattgacgg cccccactgc      840

gtcaagacct gcccggcagg agtcatggga gaaaacaaca ccctggtctg gaagtacgca      900

gacgccggcc atgtgtgcca cctgtgccat ccaaactgca cctacggatg cactgggcca      960

ggtcttgaag gctgtccaac gaatgggcct aagatcccgt ccatcgccac tgggatggtg     1020

ggggccctcc tcttgctgct ggtggtggcc ctggggatcg gcctcttcat gtga           1074


<210>  83
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct IgG4 CH3 region

<400>  83

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  84
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct IgG4 CH2 region

<400>  84

Ala Pro Glu Phe Asp Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  85
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct light chain leader sequence

<400>  85

Met Ser Val Pro Thr Gln Val Leu Gly Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Asp Ala Arg Cys 
            20  


<210>  86
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct light chain leader sequence DNA

<400>  86
atgtccgttc ccactcaagt ccttggactt ttgctgcttt ggctgaccga cgctcgatgc       60


<210>  87
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR Construct heavy chain leader sequence

<400>  87

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser 
            


<210>  88
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Constructs heavy chain leader sequence DNA

<400>  88
atggaatgga gctgggtttt cctctttttt ctttctgtca ccaccggggt gcattct          57


<210>  89
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CNA31xx -IgG4 mutant hinge linker DNA

<400>  89
gagtcaaagt acggaccgcc ctgcccccct tgccct                                 36


<210>  90
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA31xx -hinge-CH3 linker DNA

<400>  90
gagtcaaagt acggaccgcc ctgcccccct tgccctggcc agcctagaga accccaggtg       60

tacaccctgc ctcccagcca ggaagagatg accaagaacc aggtgtccct gacctgcctg      120

gtcaaaggct tctaccccag cgatatcgcc gtggaatggg agagcaacgg ccagcccgag      180

aacaactaca agaccacccc ccctgtgctg gacagcgacg gcagcttctt cctgtactcc      240

cggctgaccg tggacaagag ccggtggcag gaaggcaacg tcttcagctg cagcgtgatg      300

cacgaggccc tgcacaacca ctacacccag aagtccctga gcctgagcct gggcaag         357


<210>  91
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct CNA31xx -hinge-CH2-CH3 linker DNA

<400>  91
gagtcaaagt acggaccgcc ctgcccccct tgccctgccc ccgagttcga cggcggaccc       60

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagccg gacccccgag      120

gtgacctgcg tggtggtgga cgtgagccag gaagatcccg aggtccagtt caattggtac      180

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gttccagagc      240

acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa      300

tacaagtgca aggtgtccaa caagggcctg cccagcagca tcgaaaagac catcagcaag      360

gccaagggcc agcctcgcga gccccaggtg tacaccctgc ctccctccca ggaagagatg      420

accaagaacc aggtgtccct gacctgcctg gtgaagggct tctaccccag cgacatcgcc      480

gtggagtggg agagcaacgg ccagcctgag aacaactaca agaccacccc tcccgtgctg      540

gacagcgacg gcagcttctt cctgtacagc cggctgaccg tggacaagag ccggtggcag      600

gaaggcaacg tctttagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag      660

aagagcctga gcctgtccct gggcaag                                          687


<210>  92
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct xx02/03 - CD28 trans membrane domain DNA

<400>  92
atgttctggg tgctggtggt ggtcggaggc gtgctggcct gctacagcct gctggtcacc       60

gtggccttca tcatcttttg ggtg                                              84


<210>  93
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct xx04 - CD28 trans membrane domain  DNA

<400>  93
atgttctggg tgctggtggt ggtgggcggg gtgctggcct gctacagcct gctggtgaca       60

gtggccttca tcatcttttg ggtg                                              84


<210>  94
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct 4-1BB Signalling Domain DNA

<400>  94
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 18G7.1 heavy chain CDR1

<400>  95

Gly Tyr Thr Phe Ser Gly Tyr Trp 
1               5               


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 18G7H6A1 heavy chain CDR3

<400>  96

Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr 
1               5                   10      


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody 18G7.1 light chain CDR3

<400>  97

Gln Gln Asn Asn Glu Asp Pro Arg Thr 
1               5                   


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Scfv fusion domain

<400>  98

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  99
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Fragment Ab 18G7.1 heavy chain

<400>  99

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Gly Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Val Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  100
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Fragment Ab 18G7.1 light chain

<400>  100

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  101
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Fragment 18G7H6A1 heavy chain

<400>  101

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Ser Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly His Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Gln Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 


<210>  102
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody Fragment 18G7H6A1 light chain

<400>  102

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Ala 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  103
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct Variable Heavy Chain 31xx DNA

<400>  103
gatatcgtac tgacccaaag tccagcatct ctggcagtgt caccagggca aagagctact       60

attacttgta gagcttccga gtccgtggac agctatggca actccttcat gcattggtat      120

caacaaaaac caggacaacc acctaagttg ctcatctact tgaccagcaa cttggaatca      180

ggggttccag accggttctc tgggtccggc tccggaacgg attttactct taccataaac      240

ccggtggagg caaacgatgc tgcaacatac tactgtcaac aaaacgccga ggatccccga      300

acattcggcg gtggaacgaa gttggaaatt aag                                   333


<210>  104
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR Construct Variable Heavy Chain 31xx DNA

<400>  104
gaagtgcagt tggttcagtc cggtgcggag gtaaaaaagc cgggagaatc acttcggatt       60

agttgcaaag gatcagggta tagtttcacc gcgtactgga ttgagtgggt gagacaggcg      120

ccagggaagg gccttgaatg gattggtgag atccttccgg gctcagattc cacgaactat      180

aacgagaaat ttaagggtca tgttactatc tcagcagata aaagcatcag tacggcatat      240

cttcagtggt ccagtctgaa ggccagtgac acggctgtgt actattgcgc ccgctctggt      300

ctctacggta gttctcaata ctggggccag ggtacactcg tcaccgtatc ttcc            354


