                         SEQUENCE LISTING

<110>  HYASYNTH BIOLOGICALS INC.
 
<120>  CANNABIDIOLIC ACID SYNTHASE VARIANTS WITH IMPROVED ACTIVITY FOR 
       USE IN PRODUCTION OF PHYTOCANNABINOIDS

<130>  PAT 109719W-90

<150>  US 63/116,276
<151>  2020-11-20

<160>  207   

<170>  PatentIn version 3.5

<210>  1
<211>  7263
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OstI-pro-alpha-f(I)-OXC52

<400>  1
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtccctaagt     3600

ccaccatgtt ctccgtcaag aaaatcatgg aaattcatga gttggtcaaa ttggttaaca     3660

agtggcaaaa catcgcttac aagtatgaca aggatttgtt gttaatgact cacttcatca     3720

cccgtaatat caccgacaac caaggtaaga acaaaactgc tattcacacc tacttctcct     3780

ccgttttttt gggtggtgtc gactccttag tcgatttgat gaacaaatcc tttccagaat     3840

tgggtattaa gaaaactgat tgtagacaat tgtcttggat tgacaccatt atcttctatt     3900

ctggtgtcgt taactacgac accgacaact ttaacaagga aattttgttg gatcgttctg     3960

ctggtcaaaa tggtgccttc aaaatcaaat tggactacgt caaaaagcca atcccagaat     4020

ctgttttcgt tcaaattttg gaaaagttgt acgaagaaga cattggtgcc ggtatgtatg     4080

ctttgtatcc atatggtggt atcatggacg aaatttccga atctgccatc ccattcccac     4140

acagagctgg tattttatat gaattgtggt acatctgttc ttgggaaaag caagaagaca     4200

acgaaaagca tttaaactgg attagaaaca tttacaactt catgacccca tacgtttcta     4260

agaacccaag attagcctat ttgaactacc gtgacttaga tattggtatt aatgacccaa     4320

agaacccaaa caactatact caagccagaa tttggggtga aaagtacttc ggtaagaact     4380

tcgatagatt agttaaggtt aaaactttgg tcgatccaaa caacttcttc agaaacgaac     4440

aatccatccc accattgcca agacatcgtc acggccatca tcaccatcac cattagctcg     4500

agcatgcatc tagagggccg catcatgtaa ttagttatgt cacgcttaca ttcacgccct     4560

ccccccacat ccgctctaac cgaaaaggaa ggagttagac aacctgaagt ctaggtccct     4620

atttattttt ttatagttat gttagtatta agaacgttat ttatatttca aatttttctt     4680

ttttttctgt acagacgcgt gtacgcatgt aacattatac tgaaaacctt gcttgagaag     4740

gttttgggac gctcgaaggc tttaatttgc ggccctgcat taatgaatcg gccaacgcgc     4800

ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg     4860

ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc     4920

cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaagcccag     4980

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     5040

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     5100

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     5160

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag     5220

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     5280

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     5340

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     5400

cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt     5460

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     5520

cggcaaacaa accaccgctg gtagcggtgg tttttttgtt tgcaagcagc agattacgcg     5580

cagaaaaaaa ggatctcaag aagatccttt gatcttttct acggggtctg acgctcagtg     5640

gaacgaaaac tcacgttaag ggattttggt catgagatta tcaaaaagga tcttcaccta     5700

gatcctttta aattaaaaat gaagttttaa atcaatctaa agtatatatg agtaaacttg     5760

gtctgacagt taccaatgct taatcagtga ggcacctatc tcagcgatct gtctatttcg     5820

ttcatccata gttgcctgac tccccgtcgt gtagataact acgatacggg agcgcttacc     5880

atctggcccc agtgctgcaa tgataccgcg agacccacgc tcaccggctc cagatttatc     5940

agcaataaac cagccagccg gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc     6000

ctccattcag tctattaatt gttgccggga agctagagta agtagttcgc cagttaatag     6060

tttgcgcaac gttgttggca ttgctacagg catcgtggtg tcactctcgt cgtttggtat     6120

ggcttcattc agctccggtt cccaacgatc aaggcgagtt acatgatccc ccatgttgtg     6180

caaaaaagcg gttagctcct tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt     6240

gttatcactc atggttatgg cagcactgca taattctctt actgtcatgc catccgtaag     6300

atgcttttct gtgactggtg agtactcaac caagtcattc tgagaatagt gtatgcggcg     6360

accgagttgc tcttgcccgg cgtcaatacg ggataatagt gtatcacata gcagaacttt     6420

aaaagtgctc atcattggaa aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct     6480

gttgagatcc agttcgatgt aacccactcg tgcacccaac tgatcttcag catcttttac     6540

tttcaccagc gtttctgggt gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat     6600

aagggcgaca cggaaatgtt gaatactcat actcttcctt tttcaatggg taataactga     6660

tataattaaa ttgaagctct aatttgtgag tttagtatac atgcatttac ttataataca     6720

gttttttagt tttgctggcc gcatcttctc aaatatgctt cccagcctgc ttttctgtaa     6780

cgttcaccct ctaccttagc atcccttccc tttgcaaata gtcctcttcc aacaataata     6840

atgtcagatc ctgtagagac cacatcatcc acggttctat actgttgacc caatgcgtct     6900

cccttgtcat ctaaacccac accgggtgtc ataatcaacc aatcgtaacc ttcatctctt     6960

ccacccatgt ctctttgagc aataaagccg ataacaaaat ctttgtcgct cttcgcaatg     7020

tcaacagtac ccttagtata ttctccagta gatagggagc ccttgcatga caattctgct     7080

aacatcaaaa ggcctctagg ttcctttgtt acttcttctg ccgcctgctt caaaccgcta     7140

acaatacctg ggcccaccac accgtgtgca ttcgtaatgt ctgcccattc tgctattctg     7200

tatacacccg cagagtactg caatttgact gtattaccaa tgtcagcaaa ttttctgtct     7260

tcg                                                                   7263


<210>  2
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OstI-pro-alpha-f(I)-OXC154

<400>  2
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  3
<211>  6114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RFP mScarlet

<400>  3
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat ggtgtctaaa ggtgaagccg tcatcaaaga attcatgaga ttcaaggttc     2700

acatggaagg ttctatgaat ggtcacgaat tcgaaattga aggtgaaggt gagggtagac     2760

catatgaagg tactcaaact gctaagttga aggttacaaa aggtggtcca ttgccattct     2820

cttgggatat tttgtctcca caattcatgt acggttctag agcttttaca aaacacccag     2880

ctgatatccc agattactac aagcaatcat ttccagaggg tttcaagtgg gaaagagtta     2940

tgaattttga agatggtggt gccgttactg ttactcaaga tacttctttg gaagatggca     3000

ccttgatcta caaggttaag ttgagaggta ctaatttccc accagatggt ccagttatgc     3060

aaaaaaagac tatgggttgg gaagctagta ctgaaagatt atatccagag gatggtgttt     3120

tgaagggtga tattaagatg gccttgagat tgaaagacgg tggtagatat ttggctgatt     3180

tcaagactac ttacaaggcc aaaaagccag ttcaaatgcc aggtgcttat aacgttgata     3240

gaaagttgga tatcacctct cacaacgaag attacaccgt tgttgaacag tacgaaagat     3300

ctgaaggtag acattctact ggtggtatgg atgagttgta caagtaactc gagcatgcat     3360

ctagagggcc gcatcatgta attagttatg tcacgcttac attcacgccc tccccccaca     3420

tccgctctaa ccgaaaagga aggagttaga caacctgaag tctaggtccc tatttatttt     3480

tttatagtta tgttagtatt aagaacgtta tttatatttc aaatttttct tttttttctg     3540

tacagacgcg tgtacgcatg taacattata ctgaaaacct tgcttgagaa ggttttggga     3600

cgctcgaagg ctttaatttg cggccctgca ttaatgaatc ggccaacgcg cggggagagg     3660

cggtttgcgt attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt     3720

tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc     3780

aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaagccca ggaaccgtaa     3840

aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa     3900

tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc     3960

ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc     4020

cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta ggtatctcag     4080

ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga     4140

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc     4200

gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac     4260

agagttcttg aagtggtggc ctaactacgg ctacactaga agaacagtat ttggtatctg     4320

cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca     4380

aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa     4440

aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa     4500

ctcacgttaa gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt     4560

aaattaaaaa tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag     4620

ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat     4680

agttgcctga ctccccgtcg tgtagataac tacgatacgg gagcgcttac catctggccc     4740

cagtgctgca atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa     4800

ccagccagcc ggaagggccg agcgcagaag tggtcctgca actttatccg cctccattca     4860

gtctattaat tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa     4920

cgttgttggc attgctacag gcatcgtggt gtcactctcg tcgtttggta tggcttcatt     4980

cagctccggt tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc     5040

ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact     5100

catggttatg gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc     5160

tgtgactggt gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg     5220

ctcttgcccg gcgtcaatac gggataatag tgtatcacat agcagaactt taaaagtgct     5280

catcattgga aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc     5340

cagttcgatg taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag     5400

cgtttctggg tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac     5460

acggaaatgt tgaatactca tactcttcct ttttcaatgg gtaataactg atataattaa     5520

attgaagctc taatttgtga gtttagtata catgcattta cttataatac agttttttag     5580

ttttgctggc cgcatcttct caaatatgct tcccagcctg cttttctgta acgttcaccc     5640

tctaccttag catcccttcc ctttgcaaat agtcctcttc caacaataat aatgtcagat     5700

cctgtagaga ccacatcatc cacggttcta tactgttgac ccaatgcgtc tcccttgtca     5760

tctaaaccca caccgggtgt cataatcaac caatcgtaac cttcatctct tccacccatg     5820

tctctttgag caataaagcc gataacaaaa tctttgtcgc tcttcgcaat gtcaacagta     5880

cccttagtat attctccagt agatagggag cccttgcatg acaattctgc taacatcaaa     5940

aggcctctag gttcctttgt tacttcttct gccgcctgct tcaaaccgct aacaatacct     6000

gggcccacca caccgtgtgc attcgtaatg tctgcccatt ctgctattct gtatacaccc     6060

gcagagtact gcaatttgac tgtattacca atgtcagcaa attttctgtc ttcg           6114


<210>  4
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-S88A/L451G

<400>  4
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  5
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/S60T/S88A(=GCT)

<400>  5
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  6
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/T49R/S60T/S88A(=GCT)

<400>  6
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  7
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/T49R/S88A(=GCC)

<400>  7
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  8
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/A18E/T49R/S60T/S88A(=GCT)

<400>  8
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  9
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/T49R/S60T/S88A(=GCT)

<400>  9
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca gtcgaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  10
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/T49R/S60T/S88A(=GCC)

<400>  10
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca gtcgaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  11
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A18A(=GCC)

<400>  11
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgckac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  12
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/T49R/S88A(=GCC)

<400>  12
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  13
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/S88A(=GCC)

<400>  13
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  14
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/T49R

<400>  14
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  15
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/T49R/S88A(=GCT)

<400>  15
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  16
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGA)/A18E/T49R/S60T/S88A(=GCC)

<400>  16
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  17
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/T49R/S88A(=GCC)/V97E

<400>  17
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  18
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/S88A(=GCC)

<400>  18
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  19
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/A18E/T49R/S60T/S88A(=GCC)

<400>  19
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca gtcgaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  20
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-S60T/S88A(=GCC)

<400>  20
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  21
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/T49R/S60T/S88A(=GCT)

<400>  21
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  22
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/T49R/S88A(=GCC)/V97E

<400>  22
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  23
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/T49R/S60T

<400>  23
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  24
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-P2W/T26A/S60T

<400>  24
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgtgg agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttacg     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  25
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/S60T/S88A(=GCC)/V97E

<400>  25
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  26
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/T49R/S88A(=GCC)

<400>  26
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  27
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/S60T/S88A(=GCC)/V97D

<400>  27
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagacccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  28
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-P2W/L21G/T49R/S88A(=GCC)/V97E

<400>  28
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgtgg agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  29
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/T49R/S88A(=GCT)

<400>  29
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  30
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-S295S(=TCA)

<400>  30
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcat tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  31
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/L21G/S60T/S88A(=GCC)

<400>  31
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca gtcgaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  32
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/S88A(=GCC)

<400>  32
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  33
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-S60T/S88A(=GCT)

<400>  33
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  34
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/T49R/S88A(=GCT)

<400>  34
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  35
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-T49R/S88A(=GCC)

<400>  35
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  36
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/S47F

<400>  36
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

ctttcgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  37
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/I372L/L451G

<400>  37
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgggggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  38
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/S60T

<400>  38
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  39
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/T49R/S88A(=GCT)

<400>  39
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  40
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/S60T

<400>  40
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  41
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/S88A(=GCT)

<400>  41
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  42
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-L21G/T49R/S60T/S88A(=GCT)

<400>  42
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  43
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/A383V

<400>  43
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgggggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  44
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/T49R/S60T/S88A(=GCT)

<400>  44
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  45
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A18E/S88A(=GCC)

<400>  45
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgccga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  46
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/T49R

<400>  46
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  47
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/L451G

<400>  47
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgggggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  48
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/I372L/A383V/L451G

<400>  48
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgggggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  49
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-I372L/A383V/L451G

<400>  49
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  50
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/T49R/S88A(=GCT)

<400>  50
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca gtcgaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  51
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/S60T

<400>  51
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  52
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/I372L/A383V

<400>  52
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgggggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  53
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T

<400>  53
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  54
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/A18E/T49R/V97E

<400>  54
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca gtcgaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  55
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/T49R/S60T/S88A(=GCT)

<400>  55
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgacgctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  56
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/T49R/V97E

<400>  56
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  57
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/L21G/T49R/S60T

<400>  57
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca gtcgaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacgggaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  58
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/I372L

<400>  58
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  59
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/A383V/L451G

<400>  59
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  60
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351R/I372L/L451G

<400>  60
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatagggcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  61
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/I372L/A383V/L451G

<400>  61
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  62
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351R/I372L/A383V/L451G

<400>  62
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatagggcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  63
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/I372L/A383V

<400>  63
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  64
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-N331G/Q349G/I372L/L451G

<400>  64
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttgggtac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtgg gaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  65
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351R/A383V/L451G

<400>  65
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatagggcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  66
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-Q349G/A383V/L451G

<400>  66
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtgg gaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  67
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-A383V/L451G

<400>  67
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  68
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-N331G/Q349G

<400>  68
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttgggtac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtgg gaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  69
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I

<400>  69
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  70
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-L451G

<400>  70
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gccggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  71
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-N331G/G351I/I372L/A383V

<400>  71
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca agagaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttgggtac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaactg ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagattagcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  72
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-S88A/L451G

<400>  72

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  73
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/S60T/S88A(=GCT)

<400>  73

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  74
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/T49R/S60T/S88A(=GCT)

<400>  74

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  75
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/T49R/S88A(=GCC)

<400>  75

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  76
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/A18E/T49R/S60T/S88A(=GCT)

<400>  76

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  77
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/T49R/S60T/S88A(=GCT)

<400>  77

Met Pro Val Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  78
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/T49R/S60T/S88A(=GCC)

<400>  78

Met Pro Val Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  79
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A18A(=GCC)

<400>  79

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  80
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/T49R/S88A(=GCC)

<400>  80

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  81
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/S88A(=GCC)

<400>  81

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  82
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/T49R

<400>  82

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  83
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/T49R/S88A(=GCT)

<400>  83

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  84
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGA)/A18E/T49R/S60T/S88A(=GCC)

<400>  84

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  85
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/T49R/S88A(=GCC)/V97E

<400>  85

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  86
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/S88A(=GCC)

<400>  86

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  87
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/A18E/T49R/S60T/S88A(=GCC)

<400>  87

Met Pro Val Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  88
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-S60T/S88A(=GCC)

<400>  88

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  89
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/T49R/S60T/S88A(=GCT)

<400>  89

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  90
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/T49R/S88A(=GCC)/V97E

<400>  90

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  91
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/T49R/S60T

<400>  91

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  92
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-P2W/T26A/S60T

<400>  92

Met Trp Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Ala Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  93
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/S60T/S88A(=GCC)/V97E

<400>  93

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  94
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/T49R/S88A(=GCC)

<400>  94

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  95
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/S60T/S88A(=GCC)/V97D

<400>  95

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Asp Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  96
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-P2W/L21G/T49R/S88A(=GCC)/V97E

<400>  96

Met Trp Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  97
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/T49R/S88A(=GCT)

<400>  97

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  98
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-S295S(=TCA)

<400>  98

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  99
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/L21G/S60T/S88A(=GCC)

<400>  99

Met Pro Val Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  100
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/A18E/S88A(=GCC)

<400>  100

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  101
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-S60T/S88A(=GCT)

<400>  101

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  102
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/T49R/S88A(=GCT)

<400>  102

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  103
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-T49R/S88A(=GCC)

<400>  103

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  104
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/S47F

<400>  104

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Phe Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  105
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/I372L/L451G

<400>  105

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Gly Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  106
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/L21G/S60T

<400>  106

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  107
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/T49R/S88A(=GCT)

<400>  107

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  108
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/S60T

<400>  108

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  109
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/S88A(=GCT)

<400>  109

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  110
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-L21G/T49R/S60T/S88A(=GCT)

<400>  110

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  111
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/A383V

<400>  111

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Gly Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  112
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/T49R/S60T/S88A(=GCT)

<400>  112

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  113
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A18E/S88A(=GCC)

<400>  113

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  114
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/L21G/T49R

<400>  114

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  115
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/L451G

<400>  115

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Gly Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  116
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/I372L/A383V/L451G

<400>  116

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Gly Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  117
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-I372L/A383V/L451G

<400>  117

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  118
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/T49R/S88A(=GCT)

<400>  118

Met Pro Val Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  119
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G(=GGG)/A18E/S60T

<400>  119

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  120
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A347G/I372L/A383V

<400>  120

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Gly Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  121
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T

<400>  121

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  122
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/A18E/T49R/V97E

<400>  122

Met Pro Val Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  123
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/T49R/S60T/S88A(=GCT)

<400>  123

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ala Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  124
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/L21G/T49R/V97E

<400>  124

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  125
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3V/L21G/T49R/S60T

<400>  125

Met Pro Val Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Gly Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  126
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/I372L

<400>  126

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  127
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/A383V/L451G

<400>  127

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  128
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351R/I372L/L451G

<400>  128

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Arg Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  129
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/I372L/A383V/L451G

<400>  129

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  130
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351R/I372L/A383V/L451G

<400>  130

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Arg Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  131
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I/I372L/A383V

<400>  131

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  132
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-N331G/Q349G/I372L/L451G

<400>  132

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Gly Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gly Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  133
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351R/A383V/L451G

<400>  133

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Arg Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  134
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-Q349G/A383V/L451G

<400>  134

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gly Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  135
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-A383V/L451G

<400>  135

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  136
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-N331G/Q349G

<400>  136

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Gly Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gly Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  137
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-G351I

<400>  137

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  138
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-L451G

<400>  138

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  139
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-N331G/G351I/I372L/A383V

<400>  139

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Gly Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Leu Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  140
<211>  523
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC52

<400>  140

Met Pro Arg Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu Leu 
225                 230                 235                 240 


Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp Lys 
                245                 250                 255     


Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp Asn 
            260                 265                 270         


Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val Phe 
        275                 280                 285             


Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe Pro 
    290                 295                 300                 


Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile Asp 
305                 310                 315                 320 


Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn Phe 
                325                 330                 335     


Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala Phe 
            340                 345                 350         


Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val Phe 
        355                 360                 365             


Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly Met 
    370                 375                 380                 


Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu Ser 
385                 390                 395                 400 


Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp Tyr 
                405                 410                 415     


Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn Trp 
            420                 425                 430         


Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn Pro 
        435                 440                 445             


Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn Asp 
    450                 455                 460                 


Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu Lys 
465                 470                 475                 480 


Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu Val 
                485                 490                 495     


Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu Pro 
            500                 505                 510         


Arg His Arg His Gly His His His His His His 
        515                 520             


<210>  141
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154

<400>  141

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Leu Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  142
<211>  3564
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NpgA

<400>  142
tcaatcaaag caacccacaa atcctaggct gaatcatgat atcgatggaa gcaatcaaca       60

attttatcaa gaccgcacca aagcacgact atctgacagg cggagttcat cattctggta      120

atgtagacgt gttacaatta agcggcaata aagaagatgg tagtttagta tggaaccata      180

cttttgttga tgtagacaac aatgtggtag ctaagtttga agacgctctc gaaaaacttg      240

aaagtttgca ccggcgctca tcctcatcca caggcaatga agaacacgct aacgtttaac      300

cgaggggagt cacttcataa tgatgtgaga aataagtgaa tattgtaata attgttggga      360

ctccattgtc aacaaaagct ataatgtagg tatacagtat atactagaag ttctcctcga      420

ggatcttgga atccacaaaa gggagtcgat aaatctatat aataaaaatt actttatctt      480

ctttcgtttt atacgttgtc gtttattatc ctattacgtt atcaatcttc gcatttcagc      540

tttcattaga tttgatgact gtttctcaaa ctttatgtca ttttcttaca ccgcataaac      600

aacaaataat cataaaaatt ttagaactag acataaagca acaggcgcgt tggactttta      660

attttcgagg accgcgaatc cttacatcac acccaatccc ccacaagtga tcccccacac      720

accatagctt caaaatgttt ctactccttt tttactcttc cagattttct cggactccgc      780

gcatcgccgt accacttcaa aacacccaag cacagcatac taaatttccc ctctttcttc      840

ctctagggtg tcgttaatta cccgtactaa aggtttggaa aagaaaaaag agaccgcctc      900

gtttcttttt cttcgtcgaa aaaggcaata aaaattttta tcacgtttct ttttcttgaa      960

aatttttttt tttgattttt ttctctttcg atgacctccc attgatattt aagttaataa     1020

acggtcttca atttctcaag tttcagtttc atttttcttg ttctattaca acttttttta     1080

cttcttgctc attagaaaga aagcatagca atctaatcta agttttaatc tagaaaattt     1140

attataaaag gaagagaaat aattaaacaa tggttcaaga tacctcttct gcttctacct     1200

ctccaatttt gactagatgg tacattgata ccagaccatt gactgcttct actgctgctt     1260

tgccattatt ggaaacttta caaccagccg atcaaatctc cgttcaaaag tactatcact     1320

tgaaggacaa gcacatgtct ttggcttcta acttgttgaa gtacttgttc gttcacagaa     1380

actgcagaat tccatggtcc tctatcgtta tttctagaac tccagatcca catagaaggc     1440

catgttatat tccaccatct ggttctcaag aggattcttt taaagatggt tacaccggta     1500

tcaacgtcga gtttaatgtt tctcatcaag cctccatggt tgctattgct ggtactgctt     1560

ttactccaaa ttctggtggt gattctaagt tgaaaccaga agttggtatc gatattacct     1620

gcgtcaacga aagacaaggt agaaatggtg aagaaaggtc cttggaatct ttgagacagt     1680

acatcgatat cttctccgaa gttttctcta ctgctgaaat ggccaacatt agaagattgg     1740

atggtgtctc ttcttcctca ttgtctgctg atagattggt tgattatggc tacaggttgt     1800

tctatactta ctgggctttg aaagaagcct acattaagat gactggtgaa gccttgttgg     1860

ctccatggtt gagagaattg gaattctcta atgttgttgc tccagctgct gttgctgaat     1920

ctggtgattc tgctggtgat tttggtgaac catatactgg tgttagaacc accttgtaca     1980

agaacttggt tgaagatgtt agaattgaag ttgctgcttt gggtggtgat tacttgtttg     2040

ctactgctgc tagaggtggt ggtattggtg cttcttctag accaggtggt ggtccagatg     2100

gttctggtat tagatctcaa gatccttgga ggccattcaa gaagttggat attgaaaggg     2160

atattcaacc atgtgctact ggtgtatgta actgcttgtc ttaaagacat aaaactgaaa     2220

caacaccaat taataataga ctttacagaa gacgggagac actagcacac aactttacca     2280

ggcaaggtat ttgacgctag catgtgtcca attcagtgtc atttatgatt ttttgtagta     2340

ggatataaat atatacagcg ctccaaatag tgcggttgcc ccaaaaacac cacggaacct     2400

catctgttct cgtactttgt tgtgacaaag tagctcactg ccttattatc acattttcat     2460

tatgcaacgc ttcggaaaat acgatgttga aaatgcctct agagatgaaa aacaatcgta     2520

aaagggtcct gcgtaattga aacatttgat cagtatgcag tggcacagaa acaaccagga     2580

atactatagt cataggcaat acaaggtata tattggctat gcagacccct ccagaaagta     2640

ccgacgtcaa gttagataca cttaacgaac ctagtgcaca tttaattgag aaaaatgtgg     2700

ctcttcctaa ggacatattc cgttcgtact tgagttattg gatctatgaa atcgctcgct     2760

atacaccagt catgattttg tccttaaata acatactcat cactaaacat tcttaacaat     2820

cagaaaatgc aaccgataaa acattataaa tcttcgcggt tatctggcat tgttattaac     2880

caaaaaaatg ccggcctatt acaagctact gttcaataaa tattgttgta atgaagacgg     2940

tccaactgta caaatacagc aaactgtcat atataaggtg tcttatgtga cagcacttgc     3000

gttattgtca gccggagtat gtctttgtcg cattctgggc tttttacttt ctgctcagaa     3060

ggaagtacga acaagaaaaa aaaatcacca atgcttccct tttcagtatt agtttcatat     3120

ttgtttacgt tcaaactcgt cgtttgcgcg ataacctcta aaaaagtcag ttacgtaact     3180

atatcaatca gagaatgcaa aaagcactat cataaaaatg tctctagggg atgtgagaca     3240

tgtcaattat aagaagtgat ggtgtcatag tatatatatc ataaatgatt atcaaagttt     3300

caatcctttg tattttctag tttagcgcca acttttgaca aaacctaaac tttagataat     3360

catcattctt acaattttta tctggatggc aataatctcc tatataaagc ccagataaac     3420

tgtaaaaaga atccatcact atttgaaaaa aagtcatctg gcacgtttaa ttatcagagc     3480

agaaatgatg aagggtgtta gcgccgtcca ttgatgcgcc tggtagtcat gatttacgta     3540

taactaacac atcatgagga cggc                                            3564


<210>  143
<211>  11114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DiPKS-1

<400>  143
tggaccactt cttcttggac ttcttaccac cagcaagagc ggcagcggct ttggcagctt       60

tagacaattg ttgctttgga ggcatgttat attatgttct gagacgtaag aaagggtgaa      120

aattgatgtt agtgtcaaaa attatattac aaaatacgca gagatattct agttcctttg      180

atgaatgaat ctttcagaaa aaaaagtcaa agcaaaagca aaatggcctg cagactaaac      240

tgtatggtgg tcttggaatg ataaagatct gtttaataga tttagtagat acaatagcac      300

atctcattac ccagttatga ttgacgtcat tctgagttac aatgatctta agcaacaggc      360

gcgttggact tttaattttc gaggaccgcg aatccttaca tcacacccaa tcccccacaa      420

gtgatccccc acacaccata gcttcaaaat gtttctactc cttttttact cttccagatt      480

ttctcggact ccgcgcatcg ccgtaccact tcaaaacacc caagcacagc atactaaatt      540

tcccctcttt cttcctctag ggtgtcgtta attacccgta ctaaaggttt ggaaaagaaa      600

aaagagaccg cctcgtttct ttttcttcgt cgaaaaaggc aataaaaatt tttatcacgt      660

ttctttttct tgaaaatttt tttttttgat ttttttctct ttcgatgacc tcccattgat      720

atttaagtta ataaacggtc ttcaatttct caagtttcag tttcattttt cttgttctat      780

tacaactttt tttacttctt gctcattaga aagaaagcat agcaatctaa tctaagtttt      840

aataaacaat gaacaagaac tccaaaatcc agtccccaaa ctcttctgat gttgctgtta      900

ttggtgttgg ttttagattc ccaggtaact ctaatgaccc agaatctttg tggaacaact      960

tgttggatgg tttcgatgct attacccaag tcccaaaaga aagatgggct acttctttta     1020

gagagatggg tttgatcaag aacaagttcg gtggtttctt gaaggattct gaatggaaga     1080

atttcgaccc tttgttcttt ggtatcggtc caaaagaagc tccattcatt gatccacaac     1140

aaaggttgtt gttgtccatc gtttgggaat ctttggaaga tgcttacatc agaccagatg     1200

aattgagagg ttctaacact ggtgttttca tcggtgtttc taacaacgat tacaccaagt     1260

tgggtttcca agacaactac tctatttctc catacactat gaccggctct aactcttcat     1320

tgaactccaa cagaatttcc tactgcttcg attttagagg tccatccatt actgttgata     1380

ccgcttgttc ttcttccttg gtttctgtta atttgggtgt ccaatccatc caaatgggtg     1440

aatgtaagat tgctatttgc ggtggtgtta acgctttgtt tgatccatct acatctgttg     1500

ccttttccaa gttgggtgtt ttgtctgaaa atggcagatg caactctttt agtgatcaag     1560

cctctggtta cgttagatct gaaggtgctg gtgttgttgt tttgaagtct ttggaacaag     1620

ctaagttgga tggtgataga atctacggtg ttatcaaggg tgtttcctct aatgaagatg     1680

gtgcttctaa tggtgacaag aactctttga ctactccatc ttgtgaagcc caatccatta     1740

acatttctaa ggctatggaa aaggcctcct tgtctccatc tgatatctat tacattgaag     1800

cccatggtac tggtactcca gttggtgatc caattgaagt taaggccttg tccaagatct     1860

tctccaactc taacaacaac cagttgaaca acttctctac cgatggtaat gataacgatg     1920

atgatgatga cgataacacc tctccagaac cattattgat tggctcattc aagtccaaca     1980

tcggtcattt ggaatctgct gctggtattg cttctttgat taagtgttgc ttgatgttga     2040

agaacaggat gttggttcca tccattaact gctctaattt gaacccatcc attccattcg     2100

atcagtacaa catctccgtt atcagagaaa tcagacaatt cccaaccgat aagttggtta     2160

acatcggtat caattctttc ggtttcggtg gttctaactg ccatttgatt attcaagagt     2220

acaacaacaa cttcaagaac aactctacca tctgcaataa caacaacaac aacaataaca     2280

acatcgacta cttgatccca atctcctcta agactaagaa gtccttggat aagtacttga     2340

ttttgatcaa gaccaactcc aactaccaca aggatatttc tttcgatgac ttcgtcaagt     2400

tccaaatcaa gtctaagcag tacaacttgt ccaacagaat gactaccatt gctaacgatt     2460

ggaactcctt cattaagggt tctaacgaat tccacaactt gatcgaatct aaggatggtg     2520

aaggtggttc ttcatcttct aacagaggta ttgattccgc caatcaaatc aacactacta     2580

ctacctctac catcaacgat atcgaacctt tgttggtttt cgttttctgt ggtcaaggtc     2640

cacaatggaa tggtatgatt aagaccttgt acaactccga gaacgttttc aagaacaccg     2700

ttgatcatgt tgacagcatc ttgtacaagt acttcggtta ctccattttg aacgtcttgt     2760

ctaagatcga tgataacgac gattccatca accatccaat agttgctcaa ccatctttgt     2820

tcttgttgca aattggtttg gtcgagttgt ttaagtactg gggtatctac ccatctatct     2880

ctgttggtca ttctttcggt gaagtctctt cttattactt gtccggtatc atctctttgg     2940

aaaccgcttg taaaatcgtc tacgtcagat cctctaatca gaacaaaact atgggttccg     3000

gtaagatgtt ggttgtttct atgggtttta agcaatggaa cgatcaattc tctgctgaat     3060

ggtccgatat tgaaattgct tgttacaacg ctccagattc catagttgtt actggtaacg     3120

aagaaagatt gaaagaattg tccatcaagt tgtccgacga atccaatcaa attttcaaca     3180

ccttcttgag gtccccatgt tcttttcatt cttcccatca agaagtcatc aagggttcta     3240

tgttcgaaga gttgtctaac ttgcaatcta ctggtgaaac cgaaatccct ttgttctcta     3300

ctgttactgg tagacaagtt ttgtctggtc atgttactgc tcaacacatc tacgataatg     3360

ttagagaacc agtcttgttc caaaagacga ttgaatccat tacctcctac atcaagtctc     3420

actacccatc caatcaaaag gttatctacg ttgaaattgc tccacaccca accttgtttt     3480

cattgatcaa aaagtccatc ccatcctcca acaagaattc ctcttctgtt ttgtgtccat     3540

tgaacagaaa agaaaactcc aacaactcct acaagaagtt cgtttctcag ttgtacttca     3600

acggtgttaa cgttgacttc aacttccagt tgaactccat ttgcgataac gttaacaacg     3660

atcaccattt gaacaacgtc aagcaaaact ccttcaaaga gactaccaat tccttgccaa     3720

gataccaatg ggaacaagat gaatattggt ccgaaccatt gatctccaga aagaatagat     3780

tggaaggtcc aactacttcc ttgttgggtc atagaattat ctacagcttc ccagttttcc     3840

aatccgtttt ggacttgcaa tctgacaact acaaatactt gttggaccac ttggttaacg     3900

gtaagccagt ttttccaggt gctggttatt tggatatcat catcgaattc ttcgactacc     3960

aaaagcagca gttgaattcc tctgattcct ctaactccta catcatcaac gttgacaaga     4020

tccaattctt gaacccaatt cacttgaccg aaaacaagtt gcaaaccttg caatcttctt     4080

tcgaacctat cgttactaag aagtctgcct tctctgttaa cttcttcatc aaggataccg     4140

tcgaggatca atctaaggtt aagtctatgt ctgacgaaac ttggactaac acttgtaagg     4200

ctaccatttc cttggaacaa caacagccat ctccatcttc tactttgact ttgtctaaga     4260

agcaagactt gcagatcttg agaaacagat gcgatattag caagctagac aagtttgagt     4320

tgtacgacaa gatctctaag aatttgggct tgcagtacaa ctccttgttt caagttgttg     4380

ataccatcga aactggtaag gattgctctt ttgctacttt gtctttgcca gaagatactt     4440

tgttcaccac cattttgaac ccatgcttgt tggataactg tttccatggt ttgttgacct     4500

tgatcaacga aaagggttct ttcgttgtcg agtccatttc ttctgtttct atctacttgg     4560

agaacatcgg ttccttcaat caaacttctg ttggtaacgt ccagttctac ttgtacacca     4620

ctatttctaa agccacctcc tttagttctg aaggtacttg taagttgttc accaaggatg     4680

gttccttgat tttgtctatc ggtaagttca tcatcaagtc caccaatcca aagtctacta     4740

agaccaacga aactatcgaa tctccattgg acgaaacctt ctctattgaa tggcaatcta     4800

aggattctcc aattccaacc ccacaacaaa tccaacaaca atctccattg aactctaacc     4860

catccttcat tagatctacc atcttgaagg acatccagtt cgaacaatac tgctcctcca     4920

ttatccacaa agaattgatc aaccacgaaa agtacaagaa ccagcaatcc ttcgatatca     4980

actccttgga aaaccacttg aacgatgacc aattgatgga atccttgtcc atctccaaag     5040

aatacttgag attcttcacc aggatcatct ccatcattaa gcaataccca aagatcttga     5100

acgaaaaaga gctaaaagaa ttgaaagaaa tcatcgaatt gaagtaccca tccgaagttc     5160

agttgttgga attcgaagtt atcgagaagg tgtccatgat tatcccaaag ttgttgttcg     5220

aaaacgacaa gcaatcttcc atgaccttgt tccaagataa cttgttgacc aggttctact     5280

ccaattctaa ctctaccaga ttctacttgg aaagggtttc cgaaatggtc ttggaatcta     5340

ttagaccaat cgtcagagaa aagagggtgt tcagaatttt agagatcggt gctcgtacag     5400

gctctttgtc taatgttgtt ttgactaagt tgaacaccta cttgtccacc ttgaattcta     5460

atggtggttc tggttacaac atcatcattg agtacacctt caccgatatt tccgccaact     5520

tcattattgg tgaaatccaa gaaaccatgt gcaacttgta cccaaacgtt actttcaagt     5580

tctccgtctt ggacttggag aaagagatta ttaactcctc cgatttcttg atgggtgatt     5640

acgatatagt tttgatggcc tacgttatcc atgccgtttc taacattaag ttctccatcg     5700

aacagttgta caagttgttg tctccaagag gttggttgtt gtgtattgaa cctaagtcca     5760

acgttgtgtt ctccgatttg gttttcggtt gttttaatca gtggtggaac tactacgatg     5820

atattagaac tacccactgc tccttgtctg aatctcaatg gaatcagttg ttgttgaacc     5880

agtccttgaa caacgaatcc tcttcttctt ctaactgtta cggtggtttc tccaacgttt     5940

cttttattgg tggtgaaaag gatgtcgact cccattcttt catattgcac tgccaaaaag     6000

aatccatctc ccaaatgaag ttagccacca ctattaacaa cggtttgtca tctggttcca     6060

tcgttatcgt tttgaactct caacaattga ccaacatgaa gtcctaccca aaggttattg     6120

agtatattca agaggctacc tctttgtgca agaccattga aattatcgat tccaaggacg     6180

tcttgaactc taccaattca gttttggaaa agatccaaaa gtccttgttg gtgttctgtt     6240

tgttgggtta tgacttgttg gagaacaact accaagaaca gtctttcgaa tacgttaagt     6300

tgttgaactt gatctctact accgcctctt catctaatga taagaaacca ccaaaggtct     6360

tgttgatcac caagcaatct gaaagaatct ccaggtcttt ctactccaga tccttgattg     6420

gtatttccag aacctctatg aacgagtacc caaatttgtc cattacctct atcgatttgg     6480

ataccaacga ctactcattg cagtctttgt tgaagccaat cttcagcaac tctaagtttt     6540

ccgacaacga gttcatcttc aaaaagggct tgatgttcgt gtccaggatc tttaagaaca     6600

agcagttgct agaatcctcc aacgcttttg aaactgactc ttctaacttg tactgtaagg     6660

cctcttctga cttgtcttac aagtacgcta ttaagcagtc tatgttgacc gaaaatcaga     6720

tcgaaatcaa ggttgaatgc gtcggtatta acttcaagga caacctattc tacaagggct     6780

tgttgccaca agaaattttc agaatgggtg acatctacaa tccaccatat ggtttggaat     6840

gctctggtgt tattaccaga attggttcta acgtcaccga atactcagtt ggtcaaaatg     6900

tttttggttt cgccagacat tctttgggtt ctcatgttgt taccaacaag gatttggtta     6960

tcttgaagcc agataccatc tcattttctg aagctgcttc tatcccagtt gtttactgta     7020

ctgcttggta ctccttgttc aacattggtc agttgtctaa cgaagaatcc atcctaattc     7080

attctgctac tggtggtgta ggtttggctt ctttgaattt gttgaaaatg aagaatcagc     7140

aacagcaacc attgaccaat gtttatgcta ctgttggctc taacgagaag aagaagttct     7200

tgatcgataa cttcaacaac ttgttcaaag aggacggcga aaacattttc tctaccagag     7260

acaaagaata ctccaaccag ttggaatcca agatcgatgt tattttgaac accttgtccg     7320

gtgaattcgt cgaatctaat ttcaagtcct tgagatcctt cggtagattg attgatttgt     7380

ctgctactca cgtttacgcc aatcaacaaa ttggtctagg taacttcaag ttcgaccact     7440

tgtattctgc tgttgacttg gaaagattga tcgacgaaaa acctaagttg ttgcagtcca     7500

tcttgcaaag aattaccaac tctatcgtca acggttcctt ggaaaaaatt ccaattacca     7560

tcttcccatc caccgaaact aaggatgcta tcgaattatt gtccaagaga tcccatatcg     7620

gtaaagttgt tgtagattgc accgatatct ctaagtgtaa tcctgttggt gatgtgatca     7680

ccaacttctc tatgagattg ccaaagccaa actaccagtt gaatttgaac tccaccttgt     7740

tgattactgg tcagtctggt ttgtctatcc ctttgttgaa ttggttgttg tctaagtctg     7800

gtggtaacgt taagaacgtt gtcatcattt ctaagtccac catgaagtgg aagttgcaga     7860

ctatgatttc ccatttcgtt tccggtttcg gtatccattt taactacgtt caagtcgaca     7920

tctccaacta cgatgctttg tctgaagcta ttaagcaatt gccatctgat ttgccaccaa     7980

tcacctctgt ttttcatttg gctgctatct acaacgatgt tccaatggat caagttacca     8040

tgtctaccgt tgaatctgtt cataacccta aagttttggg tgccgttaac ttgcatagaa     8100

tctctgtttc ttttggttgg aagttgaacc acttcgtctt gttctcttct attactgcta     8160

ttaccggtta cccagaccaa tctatctaca attctgccaa ctctattttg gacgctttgt     8220

ccaactttag aaggtttatg ggtttgccat ccttctccat taacttgggt ccaatgaagg     8280

atgaaggtaa ggtttctacc aacaagagca tcaagaagct attcaagtct agaggtttgc     8340

caagcctatc cttgaacaag ttatttggtt tgttggaggt cgtcatcaac aacccatcta     8400

atcatgttat cccatcccaa ttgatttgct ccccaatcga tttcaagacc tacatcgaat     8460

ctttctcaac tatgaggcca aagttgttac acttgcaacc taccatttcc aagcagcaat     8520

cttctatcat taacgattct accaaggctt cctccaacat ttcattgcaa gataagatca     8580

cctccaaggt gtctgatttg ttgtccattc caatctccaa gatcaacttc gatcatccat     8640

tgaaacacta cggcttggat tctttgttga ccgttcaatt caaatcctgg atcgacaaag     8700

aattcgaaaa gaacttgttc acccatatcc aattggccac catctctatt aactcattct     8760

tggaaaaggt gaacggcttg tctacaaaca ataacaacaa caacaattcc aacgtcaagt     8820

cctctccatc cattgtcaaa gaagaaatcg ttaccttgga caaggatcaa caaccattgc     8880

tattgaaaga acaccagcac attatcatct ccccagatat tagaatcaac aagccaaaga     8940

gggaatcctt gattagaacc ccaatcttga acaaattcaa ccagatcacc gaatccatta     9000

tcactccatc tacaccatct ttgtcccaat ccgatgtttt gaaaactcca ccaatcaagt     9060

ctttgaacaa cactaagaac tccagcttga ttaacacccc accaattcaa tctgtccaac     9120

aacatcaaaa gcaacaacaa aaggtccaag tcatccaaca acagcaacaa ccattatcca     9180

gattgtccta caagagcaac aacaactctt tcgttttggg tatcggtatt tctgttccag     9240

gtgaacctat ttcccaacaa tccttgaaag actccatctc caatgacttt tctgataagg     9300

ctgaaactaa cgagaaggtc aagagaatct ttgagcaatc tcaaatcaag accagacact     9360

tggttagaga ttacactaag ccagagaact ccatcaagtt cagacatttg gaaaccatta     9420

ccgatgtgaa caaccagttc aagaaagttg ttccagattt ggctcaacaa gcctgtttga     9480

gagctttgaa agattggggt ggtgataagg gtgatattac ccatatagtt tctgttacct     9540

ccaccggtat tatcatccca gatgttaatt tcaagttgat cgacttgttg ggcttgaaca     9600

aggatgttga aagagtgtct ttgaacctaa tgggttgttt ggctggtttg agttctttga     9660

gaactgctgc ttctttggct aaggcttctc caagaaatag aattttggtt gtctgtaccg     9720

aagtctgctc cttgcatttt tctaatactg atggtggtga tcaaatggtc gcctcttcta     9780

tttttgctga tggttctgct gcttacatta ttggttgtaa cccaagaatt gaagaaaccc     9840

cattatacga agtcatgtgc tccattaaca gatctttccc aaataccgaa aacgccatgg     9900

tttgggattt ggaaaaagaa ggttggaact tgggtttgga tgcttctatt ccaattgtca     9960

ttggttctgg tattgaagcc ttcgttgata ctttgttgga taaggctaag ttgcaaactt    10020

ccactgctat ttctgctaag gattgcgaat tcttgattca tactggtggc aagtccatct    10080

tgatgaacat cgaaaattcc ttgggtatcg acccaaagca aactaagaat acttgggatg    10140

tttaccatgc ctacggcaat atgtcatctg cctctgttat tttcgttatg gatcatgcca    10200

gaaagtccaa gtctttgcca acttactcaa tttctttggc ttttggtcca ggtttggctt    10260

ttgaaggttg tttcttgaag aacgtcgtct gaacagaaga cgggagacac tagcacacaa    10320

ctttaccagg caaggtattt gacgctagca tgtgtccaat tcagtgtcat ttatgatttt    10380

ttgtagtagg atataaatat atacagcgct ccaaatagtg cggttgcccc aaaaacacca    10440

cggaacctca tctgttctcg tactttgttg tgacaaagta gctcactgcc ttattatcac    10500

attttcatta tgcaacgctt cggaaaatac gatgttgaaa atgcctctag agatgaaaaa    10560

caatcgtaaa agggtcctgc gtaattgaaa catttgatca gtatgcagtg gcacagaaac    10620

aaccaggaat actatagtca taggcaatac aaggtatata ttggctatgc agacccctcc    10680

agaaagtacc gacgtcaagt tagatacact taacgaacct agtgcacatt taattgagaa    10740

aaatgtggct cttcctatgg acatattccg ttcgtacttg agttattgga tctatgaaat    10800

cgctcgctat acaccagtca tgattttgtc gaagttatta tccaggaggc acggatgcaa    10860

aagatagaag acaaattaat ttccttaaaa ttcaaaatgc tcattattgt cacgctgtat    10920

gagcatttgg tgaagatttc actgggaaat gttgcaataa tttgataatc gttcgtattg    10980

gatgaaactg taacatcatc tgtttattaa gtatccgtgt tattagtata tcatcacata    11040

cggtgtaaga agataacata aagattgaga aacagtcatc aaatataatg gaagctgaaa    11100

tgcgaggatt gatg                                                      11114


<210>  144
<211>  10890
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DiPKS-2

<400>  144
acgatgattc agttcgcctt ctatcctttg tttacgtatt tgtttatata tataacttta       60

ttttttttta ttaattgggc tgcaagacaa ttttgttgtc agtgatgcct caatccttct      120

tttgcttcca tatttaccat gtggaccctt tcaaaacaga gttgtatctc tgcaggatgc      180

cctttttgac gtattgaatg gcataattgc actgtcaaag caacaggcgc gttggacttt      240

taattttcga ggaccgcgaa tccttacatc acacccaatc ccccacaagt gatcccccac      300

acaccatagc ttcaaaatgt ttctactcct tttttactct tccagatttt ctcggactcc      360

gcgcatcgcc gtaccacttc aaaacaccca agcacagcat actaaatttc ccctctttct      420

tcctctaggg tgtcgttaat tacccgtact aaaggtttgg aaaagaaaaa agagaccgcc      480

tcgtttcttt ttcttcgtcg aaaaaggcaa taaaaatttt tatcacgttt ctttttcttg      540

aaaatttttt tttttgattt ttttctcttt cgatgacctc ccattgatat ttaagttaat      600

aaacggtctt caatttctca agtttcagtt tcatttttct tgttctatta caactttttt      660

tacttcttgc tcattagaaa gaaagcatag caatctaatc taagttttaa taaacaatga      720

acaagaactc caaaatccag tccccaaact cttctgatgt tgctgttatt ggtgttggtt      780

ttagattccc aggtaactct aatgacccag aatctttgtg gaacaacttg ttggatggtt      840

tcgatgctat tacccaagtc ccaaaagaaa gatgggctac ttcttttaga gagatgggtt      900

tgatcaagaa caagttcggt ggtttcttga aggattctga atggaagaat ttcgaccctt      960

tgttctttgg tatcggtcca aaagaagctc cattcattga tccacaacaa aggttgttgt     1020

tgtccatcgt ttgggaatct ttggaagatg cttacatcag accagatgaa ttgagaggtt     1080

ctaacactgg tgttttcatc ggtgtttcta acaacgatta caccaagttg ggtttccaag     1140

acaactactc tatttctcca tacactatga ccggctctaa ctcttcattg aactccaaca     1200

gaatttccta ctgcttcgat tttagaggtc catccattac tgttgatacc gcttgttctt     1260

cttccttggt ttctgttaat ttgggtgtcc aatccatcca aatgggtgaa tgtaagattg     1320

ctatttgcgg tggtgttaac gctttgtttg atccatctac atctgttgcc ttttccaagt     1380

tgggtgtttt gtctgaaaat ggcagatgca actcttttag tgatcaagcc tctggttacg     1440

ttagatctga aggtgctggt gttgttgttt tgaagtcttt ggaacaagct aagttggatg     1500

gtgatagaat ctacggtgtt atcaagggtg tttcctctaa tgaagatggt gcttctaatg     1560

gtgacaagaa ctctttgact actccatctt gtgaagccca atccattaac atttctaagg     1620

ctatggaaaa ggcctccttg tctccatctg atatctatta cattgaagcc catggtactg     1680

gtactccagt tggtgatcca attgaagtta aggccttgtc caagatcttc tccaactcta     1740

acaacaacca gttgaacaac ttctctaccg atggtaatga taacgatgat gatgatgacg     1800

ataacacctc tccagaacca ttattgattg gctcattcaa gtccaacatc ggtcatttgg     1860

aatctgctgc tggtattgct tctttgatta agtgttgctt gatgttgaag aacaggatgt     1920

tggttccatc cattaactgc tctaatttga acccatccat tccattcgat cagtacaaca     1980

tctccgttat cagagaaatc agacaattcc caaccgataa gttggttaac atcggtatca     2040

attctttcgg tttcggtggt tctaactgcc atttgattat tcaagagtac aacaacaact     2100

tcaagaacaa ctctaccatc tgcaataaca acaacaacaa caataacaac atcgactact     2160

tgatcccaat ctcctctaag actaagaagt ccttggataa gtacttgatt ttgatcaaga     2220

ccaactccaa ctaccacaag gatatttctt tcgatgactt cgtcaagttc caaatcaagt     2280

ctaagcagta caacttgtcc aacagaatga ctaccattgc taacgattgg aactccttca     2340

ttaagggttc taacgaattc cacaacttga tcgaatctaa ggatggtgaa ggtggttctt     2400

catcttctaa cagaggtatt gattccgcca atcaaatcaa cactactact acctctacca     2460

tcaacgatat cgaacctttg ttggttttcg ttttctgtgg tcaaggtcca caatggaatg     2520

gtatgattaa gaccttgtac aactccgaga acgttttcaa gaacaccgtt gatcatgttg     2580

acagcatctt gtacaagtac ttcggttact ccattttgaa cgtcttgtct aagatcgatg     2640

ataacgacga ttccatcaac catccaatag ttgctcaacc atctttgttc ttgttgcaaa     2700

ttggtttggt cgagttgttt aagtactggg gtatctaccc atctatctct gttggtcatt     2760

ctttcggtga agtctcttct tattacttgt ccggtatcat ctctttggaa accgcttgta     2820

aaatcgtcta cgtcagatcc tctaatcaga acaaaactat gggttccggt aagatgttgg     2880

ttgtttctat gggttttaag caatggaacg atcaattctc tgctgaatgg tccgatattg     2940

aaattgcttg ttacaacgct ccagattcca tagttgttac tggtaacgaa gaaagattga     3000

aagaattgtc catcaagttg tccgacgaat ccaatcaaat tttcaacacc ttcttgaggt     3060

ccccatgttc ttttcattct tcccatcaag aagtcatcaa gggttctatg ttcgaagagt     3120

tgtctaactt gcaatctact ggtgaaaccg aaatcccttt gttctctact gttactggta     3180

gacaagtttt gtctggtcat gttactgctc aacacatcta cgataatgtt agagaaccag     3240

tcttgttcca aaagacgatt gaatccatta cctcctacat caagtctcac tacccatcca     3300

atcaaaaggt tatctacgtt gaaattgctc cacacccaac cttgttttca ttgatcaaaa     3360

agtccatccc atcctccaac aagaattcct cttctgtttt gtgtccattg aacagaaaag     3420

aaaactccaa caactcctac aagaagttcg tttctcagtt gtacttcaac ggtgttaacg     3480

ttgacttcaa cttccagttg aactccattt gcgataacgt taacaacgat caccatttga     3540

acaacgtcaa gcaaaactcc ttcaaagaga ctaccaattc cttgccaaga taccaatggg     3600

aacaagatga atattggtcc gaaccattga tctccagaaa gaatagattg gaaggtccaa     3660

ctacttcctt gttgggtcat agaattatct acagcttccc agttttccaa tccgttttgg     3720

acttgcaatc tgacaactac aaatacttgt tggaccactt ggttaacggt aagccagttt     3780

ttccaggtgc tggttatttg gatatcatca tcgaattctt cgactaccaa aagcagcagt     3840

tgaattcctc tgattcctct aactcctaca tcatcaacgt tgacaagatc caattcttga     3900

acccaattca cttgaccgaa aacaagttgc aaaccttgca atcttctttc gaacctatcg     3960

ttactaagaa gtctgccttc tctgttaact tcttcatcaa ggataccgtc gaggatcaat     4020

ctaaggttaa gtctatgtct gacgaaactt ggactaacac ttgtaaggct accatttcct     4080

tggaacaaca acagccatct ccatcttcta ctttgacttt gtctaagaag caagacttgc     4140

agatcttgag aaacagatgc gatattagca agctagacaa gtttgagttg tacgacaaga     4200

tctctaagaa tttgggcttg cagtacaact ccttgtttca agttgttgat accatcgaaa     4260

ctggtaagga ttgctctttt gctactttgt ctttgccaga agatactttg ttcaccacca     4320

ttttgaaccc atgcttgttg gataactgtt tccatggttt gttgaccttg atcaacgaaa     4380

agggttcttt cgttgtcgag tccatttctt ctgtttctat ctacttggag aacatcggtt     4440

ccttcaatca aacttctgtt ggtaacgtcc agttctactt gtacaccact atttctaaag     4500

ccacctcctt tagttctgaa ggtacttgta agttgttcac caaggatggt tccttgattt     4560

tgtctatcgg taagttcatc atcaagtcca ccaatccaaa gtctactaag accaacgaaa     4620

ctatcgaatc tccattggac gaaaccttct ctattgaatg gcaatctaag gattctccaa     4680

ttccaacccc acaacaaatc caacaacaat ctccattgaa ctctaaccca tccttcatta     4740

gatctaccat cttgaaggac atccagttcg aacaatactg ctcctccatt atccacaaag     4800

aattgatcaa ccacgaaaag tacaagaacc agcaatcctt cgatatcaac tccttggaaa     4860

accacttgaa cgatgaccaa ttgatggaat ccttgtccat ctccaaagaa tacttgagat     4920

tcttcaccag gatcatctcc atcattaagc aatacccaaa gatcttgaac gaaaaagagc     4980

taaaagaatt gaaagaaatc atcgaattga agtacccatc cgaagttcag ttgttggaat     5040

tcgaagttat cgagaaggtg tccatgatta tcccaaagtt gttgttcgaa aacgacaagc     5100

aatcttccat gaccttgttc caagataact tgttgaccag gttctactcc aattctaact     5160

ctaccagatt ctacttggaa agggtttccg aaatggtctt ggaatctatt agaccaatcg     5220

tcagagaaaa gagggtgttc agaattttag agatcggtgc tcgtacaggc tctttgtcta     5280

atgttgtttt gactaagttg aacacctact tgtccacctt gaattctaat ggtggttctg     5340

gttacaacat catcattgag tacaccttca ccgatatttc cgccaacttc attattggtg     5400

aaatccaaga aaccatgtgc aacttgtacc caaacgttac tttcaagttc tccgtcttgg     5460

acttggagaa agagattatt aactcctccg atttcttgat gggtgattac gatatagttt     5520

tgatggccta cgttatccat gccgtttcta acattaagtt ctccatcgaa cagttgtaca     5580

agttgttgtc tccaagaggt tggttgttgt gtattgaacc taagtccaac gttgtgttct     5640

ccgatttggt tttcggttgt tttaatcagt ggtggaacta ctacgatgat attagaacta     5700

cccactgctc cttgtctgaa tctcaatgga atcagttgtt gttgaaccag tccttgaaca     5760

acgaatcctc ttcttcttct aactgttacg gtggtttctc caacgtttct tttattggtg     5820

gtgaaaagga tgtcgactcc cattctttca tattgcactg ccaaaaagaa tccatctccc     5880

aaatgaagtt agccaccact attaacaacg gtttgtcatc tggttccatc gttatcgttt     5940

tgaactctca acaattgacc aacatgaagt cctacccaaa ggttattgag tatattcaag     6000

aggctacctc tttgtgcaag accattgaaa ttatcgattc caaggacgtc ttgaactcta     6060

ccaattcagt tttggaaaag atccaaaagt ccttgttggt gttctgtttg ttgggttatg     6120

acttgttgga gaacaactac caagaacagt ctttcgaata cgttaagttg ttgaacttga     6180

tctctactac cgcctcttca tctaatgata agaaaccacc aaaggtcttg ttgatcacca     6240

agcaatctga aagaatctcc aggtctttct actccagatc cttgattggt atttccagaa     6300

cctctatgaa cgagtaccca aatttgtcca ttacctctat cgatttggat accaacgact     6360

actcattgca gtctttgttg aagccaatct tcagcaactc taagttttcc gacaacgagt     6420

tcatcttcaa aaagggcttg atgttcgtgt ccaggatctt taagaacaag cagttgctag     6480

aatcctccaa cgcttttgaa actgactctt ctaacttgta ctgtaaggcc tcttctgact     6540

tgtcttacaa gtacgctatt aagcagtcta tgttgaccga aaatcagatc gaaatcaagg     6600

ttgaatgcgt cggtattaac ttcaaggaca acctattcta caagggcttg ttgccacaag     6660

aaattttcag aatgggtgac atctacaatc caccatatgg tttggaatgc tctggtgtta     6720

ttaccagaat tggttctaac gtcaccgaat actcagttgg tcaaaatgtt tttggtttcg     6780

ccagacattc tttgggttct catgttgtta ccaacaagga tttggttatc ttgaagccag     6840

ataccatctc attttctgaa gctgcttcta tcccagttgt ttactgtact gcttggtact     6900

ccttgttcaa cattggtcag ttgtctaacg aagaatccat cctaattcat tctgctactg     6960

gtggtgtagg tttggcttct ttgaatttgt tgaaaatgaa gaatcagcaa cagcaaccat     7020

tgaccaatgt ttatgctact gttggctcta acgagaagaa gaagttcttg atcgataact     7080

tcaacaactt gttcaaagag gacggcgaaa acattttctc taccagagac aaagaatact     7140

ccaaccagtt ggaatccaag atcgatgtta ttttgaacac cttgtccggt gaattcgtcg     7200

aatctaattt caagtccttg agatccttcg gtagattgat tgatttgtct gctactcacg     7260

tttacgccaa tcaacaaatt ggtctaggta acttcaagtt cgaccacttg tattctgctg     7320

ttgacttgga aagattgatc gacgaaaaac ctaagttgtt gcagtccatc ttgcaaagaa     7380

ttaccaactc tatcgtcaac ggttccttgg aaaaaattcc aattaccatc ttcccatcca     7440

ccgaaactaa ggatgctatc gaattattgt ccaagagatc ccatatcggt aaagttgttg     7500

tagattgcac cgatatctct aagtgtaatc ctgttggtga tgtgatcacc aacttctcta     7560

tgagattgcc aaagccaaac taccagttga atttgaactc caccttgttg attactggtc     7620

agtctggttt gtctatccct ttgttgaatt ggttgttgtc taagtctggt ggtaacgtta     7680

agaacgttgt catcatttct aagtccacca tgaagtggaa gttgcagact atgatttccc     7740

atttcgtttc cggtttcggt atccatttta actacgttca agtcgacatc tccaactacg     7800

atgctttgtc tgaagctatt aagcaattgc catctgattt gccaccaatc acctctgttt     7860

ttcatttggc tgctatctac aacgatgttc caatggatca agttaccatg tctaccgttg     7920

aatctgttca taaccctaaa gttttgggtg ccgttaactt gcatagaatc tctgtttctt     7980

ttggttggaa gttgaaccac ttcgtcttgt tctcttctat tactgctatt accggttacc     8040

cagaccaatc tatctacaat tctgccaact ctattttgga cgctttgtcc aactttagaa     8100

ggtttatggg tttgccatcc ttctccatta acttgggtcc aatgaaggat gaaggtaagg     8160

tttctaccaa caagagcatc aagaagctat tcaagtctag aggtttgcca agcctatcct     8220

tgaacaagtt atttggtttg ttggaggtcg tcatcaacaa cccatctaat catgttatcc     8280

catcccaatt gatttgctcc ccaatcgatt tcaagaccta catcgaatct ttctcaacta     8340

tgaggccaaa gttgttacac ttgcaaccta ccatttccaa gcagcaatct tctatcatta     8400

acgattctac caaggcttcc tccaacattt cattgcaaga taagatcacc tccaaggtgt     8460

ctgatttgtt gtccattcca atctccaaga tcaacttcga tcatccattg aaacactacg     8520

gcttggattc tttgttgacc gttcaattca aatcctggat cgacaaagaa ttcgaaaaga     8580

acttgttcac ccatatccaa ttggccacca tctctattaa ctcattcttg gaaaaggtga     8640

acggcttgtc tacaaacaat aacaacaaca acaattccaa cgtcaagtcc tctccatcca     8700

ttgtcaaaga agaaatcgtt accttggaca aggatcaaca accattgcta ttgaaagaac     8760

accagcacat tatcatctcc ccagatatta gaatcaacaa gccaaagagg gaatccttga     8820

ttagaacccc aatcttgaac aaattcaacc agatcaccga atccattatc actccatcta     8880

caccatcttt gtcccaatcc gatgttttga aaactccacc aatcaagtct ttgaacaaca     8940

ctaagaactc cagcttgatt aacaccccac caattcaatc tgtccaacaa catcaaaagc     9000

aacaacaaaa ggtccaagtc atccaacaac agcaacaacc attatccaga ttgtcctaca     9060

agagcaacaa caactctttc gttttgggta tcggtatttc tgttccaggt gaacctattt     9120

cccaacaatc cttgaaagac tccatctcca atgacttttc tgataaggct gaaactaacg     9180

agaaggtcaa gagaatcttt gagcaatctc aaatcaagac cagacacttg gttagagatt     9240

acactaagcc agagaactcc atcaagttca gacatttgga aaccattacc gatgtgaaca     9300

accagttcaa gaaagttgtt ccagatttgg ctcaacaagc ctgtttgaga gctttgaaag     9360

attggggtgg tgataagggt gatattaccc atatagtttc tgttacctcc accggtatta     9420

tcatcccaga tgttaatttc aagttgatcg acttgttggg cttgaacaag gatgttgaaa     9480

gagtgtcttt gaacctaatg ggttgtttgg ctggtttgag ttctttgaga actgctgctt     9540

ctttggctaa ggcttctcca agaaatagaa ttttggttgt ctgtaccgaa gtctgctcct     9600

tgcatttttc taatactgat ggtggtgatc aaatggtcgc ctcttctatt tttgctgatg     9660

gttctgctgc ttacattatt ggttgtaacc caagaattga agaaacccca ttatacgaag     9720

tcatgtgctc cattaacaga tctttcccaa ataccgaaaa cgccatggtt tgggatttgg     9780

aaaaagaagg ttggaacttg ggtttggatg cttctattcc aattgtcatt ggttctggta     9840

ttgaagcctt cgttgatact ttgttggata aggctaagtt gcaaacttcc actgctattt     9900

ctgctaagga ttgcgaattc ttgattcata ctggtggcaa gtccatcttg atgaacatcg     9960

aaaattcctt gggtatcgac ccaaagcaaa ctaagaatac ttgggatgtt taccatgcct    10020

acggcaatat gtcatctgcc tctgttattt tcgttatgga tcatgccaga aagtccaagt    10080

ctttgccaac ttactcaatt tctttggctt ttggtccagg tttggctttt gaaggttgtt    10140

tcttgaagaa cgtcgtctga acagaagacg ggagacacta gcacacaact ttaccaggca    10200

aggtatttga cgctagcatg tgtccaattc agtgtcattt atgatttttt gtagtaggat    10260

ataaatatat acagcgctcc aaatagtgcg gttgccccaa aaacaccacg gaacctcatc    10320

tgttctcgta ctttgttgtg acaaagtagc tcactgcctt attatcacat tttcattatg    10380

caacgcttcg gaaaatacga tgttgaaaat gcctctagag atgaaaaaca atcgtaaaag    10440

ggtcctgcgt aattgaaaca tttgatcagt atgcagtggc acagaaacaa ccaggaatac    10500

tatagtcata ggcaatacaa ggtatatatt ggctatgcag acccctccag aaagtaccga    10560

cgtcaagtta gatacactta acgaacctag tgcacattta attgagaaaa atgtggctct    10620

tcctaaggac atattccgtt cgtacttgag ttattggatc tatgaaatcg ctcgctatac    10680

accagtcatg attttgtcta tgtgttgctc ttaaaatatt tggatacgac atcctttatc    10740

ttttttcctt taagagcagg atataagcca tcaagtttct gaaaatcaaa atggtagcaa    10800

caataatgca gacgacaaca actgtgctga cgacagtcgc cgcaatgtct actaccttag    10860

catcaaatta catatcttcg caagctagtt                                     10890


<210>  145
<211>  11300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DiPKS-3

<400>  145
cgggttacag tcatcgttga aaacgatgga aaaacatgtc gagattcctc aatccataca       60

ccattatagt ccgttttatc agcttccact aattttttaa atctcagttt cttcttgaaa      120

tttagcatcg tgcatgggat agcggctagt aaaaaagaaa attaatatct cattaacaaa      180

gttattgtac ataatccggt acaatattct tcaatgtact ctctaatatc gagcacactg      240

gcaatattca tgcacacatt cgcctaatgc tgacgaatgc ttaatcagtg caattaagca      300

acaggcgcgt tggactttta attttcgagg accgcgaatc cttacatcac acccaatccc      360

ccacaagtga tcccccacac accatagctt caaaatgttt ctactccttt tttactcttc      420

cagattttct cggactccgc gcatcgccgt accacttcaa aacacccaag cacagcatac      480

taaatttccc ctctttcttc ctctagggtg tcgttaatta cccgtactaa aggtttggaa      540

aagaaaaaag agaccgcctc gtttcttttt cttcgtcgaa aaaggcaata aaaattttta      600

tcacgtttct ttttcttgaa aatttttttt tttgattttt ttctctttcg atgacctccc      660

attgatattt aagttaataa acggtcttca atttctcaag tttcagtttc atttttcttg      720

ttctattaca acttttttta cttcttgctc attagaaaga aagcatagca atctaatcta      780

agttttaata aacaatgaac aagaactcca aaatccagtc cccaaactct tctgatgttg      840

ctgttattgg tgttggtttt agattcccag gtaactctaa tgacccagaa tctttgtgga      900

acaacttgtt ggatggtttc gatgctatta cccaagtccc aaaagaaaga tgggctactt      960

cttttagaga gatgggtttg atcaagaaca agttcggtgg tttcttgaag gattctgaat     1020

ggaagaattt cgaccctttg ttctttggta tcggtccaaa agaagctcca ttcattgatc     1080

cacaacaaag gttgttgttg tccatcgttt gggaatcttt ggaagatgct tacatcagac     1140

cagatgaatt gagaggttct aacactggtg ttttcatcgg tgtttctaac aacgattaca     1200

ccaagttggg tttccaagac aactactcta tttctccata cactatgacc ggctctaact     1260

cttcattgaa ctccaacaga atttcctact gcttcgattt tagaggtcca tccattactg     1320

ttgataccgc ttgttcttct tccttggttt ctgttaattt gggtgtccaa tccatccaaa     1380

tgggtgaatg taagattgct atttgcggtg gtgttaacgc tttgtttgat ccatctacat     1440

ctgttgcctt ttccaagttg ggtgttttgt ctgaaaatgg cagatgcaac tcttttagtg     1500

atcaagcctc tggttacgtt agatctgaag gtgctggtgt tgttgttttg aagtctttgg     1560

aacaagctaa gttggatggt gatagaatct acggtgttat caagggtgtt tcctctaatg     1620

aagatggtgc ttctaatggt gacaagaact ctttgactac tccatcttgt gaagcccaat     1680

ccattaacat ttctaaggct atggaaaagg cctccttgtc tccatctgat atctattaca     1740

ttgaagccca tggtactggt actccagttg gtgatccaat tgaagttaag gccttgtcca     1800

agatcttctc caactctaac aacaaccagt tgaacaactt ctctaccgat ggtaatgata     1860

acgatgatga tgatgacgat aacacctctc cagaaccatt attgattggc tcattcaagt     1920

ccaacatcgg tcatttggaa tctgctgctg gtattgcttc tttgattaag tgttgcttga     1980

tgttgaagaa caggatgttg gttccatcca ttaactgctc taatttgaac ccatccattc     2040

cattcgatca gtacaacatc tccgttatca gagaaatcag acaattccca accgataagt     2100

tggttaacat cggtatcaat tctttcggtt tcggtggttc taactgccat ttgattattc     2160

aagagtacaa caacaacttc aagaacaact ctaccatctg caataacaac aacaacaaca     2220

ataacaacat cgactacttg atcccaatct cctctaagac taagaagtcc ttggataagt     2280

acttgatttt gatcaagacc aactccaact accacaagga tatttctttc gatgacttcg     2340

tcaagttcca aatcaagtct aagcagtaca acttgtccaa cagaatgact accattgcta     2400

acgattggaa ctccttcatt aagggttcta acgaattcca caacttgatc gaatctaagg     2460

atggtgaagg tggttcttca tcttctaaca gaggtattga ttccgccaat caaatcaaca     2520

ctactactac ctctaccatc aacgatatcg aacctttgtt ggttttcgtt ttctgtggtc     2580

aaggtccaca atggaatggt atgattaaga ccttgtacaa ctccgagaac gttttcaaga     2640

acaccgttga tcatgttgac agcatcttgt acaagtactt cggttactcc attttgaacg     2700

tcttgtctaa gatcgatgat aacgacgatt ccatcaacca tccaatagtt gctcaaccat     2760

ctttgttctt gttgcaaatt ggtttggtcg agttgtttaa gtactggggt atctacccat     2820

ctatctctgt tggtcattct ttcggtgaag tctcttctta ttacttgtcc ggtatcatct     2880

ctttggaaac cgcttgtaaa atcgtctacg tcagatcctc taatcagaac aaaactatgg     2940

gttccggtaa gatgttggtt gtttctatgg gttttaagca atggaacgat caattctctg     3000

ctgaatggtc cgatattgaa attgcttgtt acaacgctcc agattccata gttgttactg     3060

gtaacgaaga aagattgaaa gaattgtcca tcaagttgtc cgacgaatcc aatcaaattt     3120

tcaacacctt cttgaggtcc ccatgttctt ttcattcttc ccatcaagaa gtcatcaagg     3180

gttctatgtt cgaagagttg tctaacttgc aatctactgg tgaaaccgaa atccctttgt     3240

tctctactgt tactggtaga caagttttgt ctggtcatgt tactgctcaa cacatctacg     3300

ataatgttag agaaccagtc ttgttccaaa agacgattga atccattacc tcctacatca     3360

agtctcacta cccatccaat caaaaggtta tctacgttga aattgctcca cacccaacct     3420

tgttttcatt gatcaaaaag tccatcccat cctccaacaa gaattcctct tctgttttgt     3480

gtccattgaa cagaaaagaa aactccaaca actcctacaa gaagttcgtt tctcagttgt     3540

acttcaacgg tgttaacgtt gacttcaact tccagttgaa ctccatttgc gataacgtta     3600

acaacgatca ccatttgaac aacgtcaagc aaaactcctt caaagagact accaattcct     3660

tgccaagata ccaatgggaa caagatgaat attggtccga accattgatc tccagaaaga     3720

atagattgga aggtccaact acttccttgt tgggtcatag aattatctac agcttcccag     3780

ttttccaatc cgttttggac ttgcaatctg acaactacaa atacttgttg gaccacttgg     3840

ttaacggtaa gccagttttt ccaggtgctg gttatttgga tatcatcatc gaattcttcg     3900

actaccaaaa gcagcagttg aattcctctg attcctctaa ctcctacatc atcaacgttg     3960

acaagatcca attcttgaac ccaattcact tgaccgaaaa caagttgcaa accttgcaat     4020

cttctttcga acctatcgtt actaagaagt ctgccttctc tgttaacttc ttcatcaagg     4080

ataccgtcga ggatcaatct aaggttaagt ctatgtctga cgaaacttgg actaacactt     4140

gtaaggctac catttccttg gaacaacaac agccatctcc atcttctact ttgactttgt     4200

ctaagaagca agacttgcag atcttgagaa acagatgcga tattagcaag ctagacaagt     4260

ttgagttgta cgacaagatc tctaagaatt tgggcttgca gtacaactcc ttgtttcaag     4320

ttgttgatac catcgaaact ggtaaggatt gctcttttgc tactttgtct ttgccagaag     4380

atactttgtt caccaccatt ttgaacccat gcttgttgga taactgtttc catggtttgt     4440

tgaccttgat caacgaaaag ggttctttcg ttgtcgagtc catttcttct gtttctatct     4500

acttggagaa catcggttcc ttcaatcaaa cttctgttgg taacgtccag ttctacttgt     4560

acaccactat ttctaaagcc acctccttta gttctgaagg tacttgtaag ttgttcacca     4620

aggatggttc cttgattttg tctatcggta agttcatcat caagtccacc aatccaaagt     4680

ctactaagac caacgaaact atcgaatctc cattggacga aaccttctct attgaatggc     4740

aatctaagga ttctccaatt ccaaccccac aacaaatcca acaacaatct ccattgaact     4800

ctaacccatc cttcattaga tctaccatct tgaaggacat ccagttcgaa caatactgct     4860

cctccattat ccacaaagaa ttgatcaacc acgaaaagta caagaaccag caatccttcg     4920

atatcaactc cttggaaaac cacttgaacg atgaccaatt gatggaatcc ttgtccatct     4980

ccaaagaata cttgagattc ttcaccagga tcatctccat cattaagcaa tacccaaaga     5040

tcttgaacga aaaagagcta aaagaattga aagaaatcat cgaattgaag tacccatccg     5100

aagttcagtt gttggaattc gaagttatcg agaaggtgtc catgattatc ccaaagttgt     5160

tgttcgaaaa cgacaagcaa tcttccatga ccttgttcca agataacttg ttgaccaggt     5220

tctactccaa ttctaactct accagattct acttggaaag ggtttccgaa atggtcttgg     5280

aatctattag accaatcgtc agagaaaaga gggtgttcag aattttagag atcggtgctc     5340

gtacaggctc tttgtctaat gttgttttga ctaagttgaa cacctacttg tccaccttga     5400

attctaatgg tggttctggt tacaacatca tcattgagta caccttcacc gatatttccg     5460

ccaacttcat tattggtgaa atccaagaaa ccatgtgcaa cttgtaccca aacgttactt     5520

tcaagttctc cgtcttggac ttggagaaag agattattaa ctcctccgat ttcttgatgg     5580

gtgattacga tatagttttg atggcctacg ttatccatgc cgtttctaac attaagttct     5640

ccatcgaaca gttgtacaag ttgttgtctc caagaggttg gttgttgtgt attgaaccta     5700

agtccaacgt tgtgttctcc gatttggttt tcggttgttt taatcagtgg tggaactact     5760

acgatgatat tagaactacc cactgctcct tgtctgaatc tcaatggaat cagttgttgt     5820

tgaaccagtc cttgaacaac gaatcctctt cttcttctaa ctgttacggt ggtttctcca     5880

acgtttcttt tattggtggt gaaaaggatg tcgactccca ttctttcata ttgcactgcc     5940

aaaaagaatc catctcccaa atgaagttag ccaccactat taacaacggt ttgtcatctg     6000

gttccatcgt tatcgttttg aactctcaac aattgaccaa catgaagtcc tacccaaagg     6060

ttattgagta tattcaagag gctacctctt tgtgcaagac cattgaaatt atcgattcca     6120

aggacgtctt gaactctacc aattcagttt tggaaaagat ccaaaagtcc ttgttggtgt     6180

tctgtttgtt gggttatgac ttgttggaga acaactacca agaacagtct ttcgaatacg     6240

ttaagttgtt gaacttgatc tctactaccg cctcttcatc taatgataag aaaccaccaa     6300

aggtcttgtt gatcaccaag caatctgaaa gaatctccag gtctttctac tccagatcct     6360

tgattggtat ttccagaacc tctatgaacg agtacccaaa tttgtccatt acctctatcg     6420

atttggatac caacgactac tcattgcagt ctttgttgaa gccaatcttc agcaactcta     6480

agttttccga caacgagttc atcttcaaaa agggcttgat gttcgtgtcc aggatcttta     6540

agaacaagca gttgctagaa tcctccaacg cttttgaaac tgactcttct aacttgtact     6600

gtaaggcctc ttctgacttg tcttacaagt acgctattaa gcagtctatg ttgaccgaaa     6660

atcagatcga aatcaaggtt gaatgcgtcg gtattaactt caaggacaac ctattctaca     6720

agggcttgtt gccacaagaa attttcagaa tgggtgacat ctacaatcca ccatatggtt     6780

tggaatgctc tggtgttatt accagaattg gttctaacgt caccgaatac tcagttggtc     6840

aaaatgtttt tggtttcgcc agacattctt tgggttctca tgttgttacc aacaaggatt     6900

tggttatctt gaagccagat accatctcat tttctgaagc tgcttctatc ccagttgttt     6960

actgtactgc ttggtactcc ttgttcaaca ttggtcagtt gtctaacgaa gaatccatcc     7020

taattcattc tgctactggt ggtgtaggtt tggcttcttt gaatttgttg aaaatgaaga     7080

atcagcaaca gcaaccattg accaatgttt atgctactgt tggctctaac gagaagaaga     7140

agttcttgat cgataacttc aacaacttgt tcaaagagga cggcgaaaac attttctcta     7200

ccagagacaa agaatactcc aaccagttgg aatccaagat cgatgttatt ttgaacacct     7260

tgtccggtga attcgtcgaa tctaatttca agtccttgag atccttcggt agattgattg     7320

atttgtctgc tactcacgtt tacgccaatc aacaaattgg tctaggtaac ttcaagttcg     7380

accacttgta ttctgctgtt gacttggaaa gattgatcga cgaaaaacct aagttgttgc     7440

agtccatctt gcaaagaatt accaactcta tcgtcaacgg ttccttggaa aaaattccaa     7500

ttaccatctt cccatccacc gaaactaagg atgctatcga attattgtcc aagagatccc     7560

atatcggtaa agttgttgta gattgcaccg atatctctaa gtgtaatcct gttggtgatg     7620

tgatcaccaa cttctctatg agattgccaa agccaaacta ccagttgaat ttgaactcca     7680

ccttgttgat tactggtcag tctggtttgt ctatcccttt gttgaattgg ttgttgtcta     7740

agtctggtgg taacgttaag aacgttgtca tcatttctaa gtccaccatg aagtggaagt     7800

tgcagactat gatttcccat ttcgtttccg gtttcggtat ccattttaac tacgttcaag     7860

tcgacatctc caactacgat gctttgtctg aagctattaa gcaattgcca tctgatttgc     7920

caccaatcac ctctgttttt catttggctg ctatctacaa cgatgttcca atggatcaag     7980

ttaccatgtc taccgttgaa tctgttcata accctaaagt tttgggtgcc gttaacttgc     8040

atagaatctc tgtttctttt ggttggaagt tgaaccactt cgtcttgttc tcttctatta     8100

ctgctattac cggttaccca gaccaatcta tctacaattc tgccaactct attttggacg     8160

ctttgtccaa ctttagaagg tttatgggtt tgccatcctt ctccattaac ttgggtccaa     8220

tgaaggatga aggtaaggtt tctaccaaca agagcatcaa gaagctattc aagtctagag     8280

gtttgccaag cctatccttg aacaagttat ttggtttgtt ggaggtcgtc atcaacaacc     8340

catctaatca tgttatccca tcccaattga tttgctcccc aatcgatttc aagacctaca     8400

tcgaatcttt ctcaactatg aggccaaagt tgttacactt gcaacctacc atttccaagc     8460

agcaatcttc tatcattaac gattctacca aggcttcctc caacatttca ttgcaagata     8520

agatcacctc caaggtgtct gatttgttgt ccattccaat ctccaagatc aacttcgatc     8580

atccattgaa acactacggc ttggattctt tgttgaccgt tcaattcaaa tcctggatcg     8640

acaaagaatt cgaaaagaac ttgttcaccc atatccaatt ggccaccatc tctattaact     8700

cattcttgga aaaggtgaac ggcttgtcta caaacaataa caacaacaac aattccaacg     8760

tcaagtcctc tccatccatt gtcaaagaag aaatcgttac cttggacaag gatcaacaac     8820

cattgctatt gaaagaacac cagcacatta tcatctcccc agatattaga atcaacaagc     8880

caaagaggga atccttgatt agaaccccaa tcttgaacaa attcaaccag atcaccgaat     8940

ccattatcac tccatctaca ccatctttgt cccaatccga tgttttgaaa actccaccaa     9000

tcaagtcttt gaacaacact aagaactcca gcttgattaa caccccacca attcaatctg     9060

tccaacaaca tcaaaagcaa caacaaaagg tccaagtcat ccaacaacag caacaaccat     9120

tatccagatt gtcctacaag agcaacaaca actctttcgt tttgggtatc ggtatttctg     9180

ttccaggtga acctatttcc caacaatcct tgaaagactc catctccaat gacttttctg     9240

ataaggctga aactaacgag aaggtcaaga gaatctttga gcaatctcaa atcaagacca     9300

gacacttggt tagagattac actaagccag agaactccat caagttcaga catttggaaa     9360

ccattaccga tgtgaacaac cagttcaaga aagttgttcc agatttggct caacaagcct     9420

gtttgagagc tttgaaagat tggggtggtg ataagggtga tattacccat atagtttctg     9480

ttacctccac cggtattatc atcccagatg ttaatttcaa gttgatcgac ttgttgggct     9540

tgaacaagga tgttgaaaga gtgtctttga acctaatggg ttgtttggct ggtttgagtt     9600

ctttgagaac tgctgcttct ttggctaagg cttctccaag aaatagaatt ttggttgtct     9660

gtaccgaagt ctgctccttg catttttcta atactgatgg tggtgatcaa atggtcgcct     9720

cttctatttt tgctgatggt tctgctgctt acattattgg ttgtaaccca agaattgaag     9780

aaaccccatt atacgaagtc atgtgctcca ttaacagatc tttcccaaat accgaaaacg     9840

ccatggtttg ggatttggaa aaagaaggtt ggaacttggg tttggatgct tctattccaa     9900

ttgtcattgg ttctggtatt gaagccttcg ttgatacttt gttggataag gctaagttgc     9960

aaacttccac tgctatttct gctaaggatt gcgaattctt gattcatact ggtggcaagt    10020

ccatcttgat gaacatcgaa aattccttgg gtatcgaccc aaagcaaact aagaatactt    10080

gggatgttta ccatgcctac ggcaatatgt catctgcctc tgttattttc gttatggatc    10140

atgccagaaa gtccaagtct ttgccaactt actcaatttc tttggctttt ggtccaggtt    10200

tggcttttga aggttgtttc ttgaagaacg tcgtctgaac agaagacggg agacactagc    10260

acacaacttt accaggcaag gtatttgacg ctagcatgtg tccaattcag tgtcatttat    10320

gattttttgt agtaggatat aaatatatac agcgctccaa atagtgcggt tgccccaaaa    10380

acaccacgga acctcatctg ttctcgtact ttgttgtgac aaagtagctc actgccttat    10440

tatcacattt tcattatgca acgcttcgga aaatacgatg ttgaaaatgc ctctagagat    10500

gaaaaacaat cgtaaaaggg tcctgcgtaa ttgaaacatt tgatcagtat gcagtggcac    10560

agaaacaacc aggaatacta tagtcatagg caatacaagg tatatattgg ctatgcagac    10620

ccctccagaa agtaccgacg tcaagttaga tacacttaac gaacctagtg cacatttaat    10680

tgagaaaaat gtggctcttc ctaaggacat attccgttcg tacttgagtt attggatcta    10740

tgaaatcgct cgctatacac cagtcatgat tttgtctgag atcgacttgc atcaaccttt    10800

gaaaaatata aggatgagaa agtgaaatcg gttttttttt tccattgtcg tcatcaacat    10860

gattttttaa ataaataaat acgatttttt attttttttc ccttctttgt ttttgttttg    10920

cttattccca tcttcattat taaattcttc cgctcttaat aaaggagttt ttttattatc    10980

ttcttgtgta atcatccttt ttctttaatt ttcttccttt tctttttctc tttactggtt    11040

tttttacttc tttattctca accatctaaa gaatattatt gctttctacc aataaaatct    11100

gttaattcta tttggattgt cgtctactca agtctcgcct agtaaataaa cgataaacaa    11160

atttgaagta agaataacaa tatagggaga gaaatttttc tatttttaat ttcgaaacag    11220

gtaccaaaaa atctaagttc actttagcac tatttgggaa agcttttata taaaaaatct    11280

gaaacaaaat catatcaaag                                                11300


<210>  146
<211>  11140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DiPKS-4

<400>  146
cggcacccac cataaagatt actttagcgt tggggttgct tttcatatga gcagcgatct       60

tcctaaccga catctctgta gaggcggtag aaacagacat cgaaacacgg agagatcgcg      120

gtacgtctgg ttggtagctc agtgacgggc acagatagcg acatttactg atacagagac      180

agttacgaaa gatggaaaca catgcagaga atgtggtcta ttccttattc ttaagatcgg      240

cgaagctaac agagttaatg ctgggccata gctggacggc agaaagcacg caggaagcaa      300

caggcgcgtt ggacttttaa ttttcgagga ccgcgaatcc ttacatcaca cccaatcccc      360

cacaagtgat cccccacaca ccatagcttc aaaatgtttc tactcctttt ttactcttcc      420

agattttctc ggactccgcg catcgccgta ccacttcaaa acacccaagc acagcatact      480

aaatttcccc tctttcttcc tctagggtgt cgttaattac ccgtactaaa ggtttggaaa      540

agaaaaaaga gaccgcctcg tttctttttc ttcgtcgaaa aaggcaataa aaatttttat      600

cacgtttctt tttcttgaaa attttttttt ttgatttttt tctctttcga tgacctccca      660

ttgatattta agttaataaa cggtcttcaa tttctcaagt ttcagtttca tttttcttgt      720

tctattacaa ctttttttac ttcttgctca ttagaaagaa agcatagcaa tctaatctaa      780

gttttaataa acaatgaaca agaactccaa aatccagtcc ccaaactctt ctgatgttgc      840

tgttattggt gttggtttta gattcccagg taactctaat gacccagaat ctttgtggaa      900

caacttgttg gatggtttcg atgctattac ccaagtccca aaagaaagat gggctacttc      960

ttttagagag atgggtttga tcaagaacaa gttcggtggt ttcttgaagg attctgaatg     1020

gaagaatttc gaccctttgt tctttggtat cggtccaaaa gaagctccat tcattgatcc     1080

acaacaaagg ttgttgttgt ccatcgtttg ggaatctttg gaagatgctt acatcagacc     1140

agatgaattg agaggttcta acactggtgt tttcatcggt gtttctaaca acgattacac     1200

caagttgggt ttccaagaca actactctat ttctccatac actatgaccg gctctaactc     1260

ttcattgaac tccaacagaa tttcctactg cttcgatttt agaggtccat ccattactgt     1320

tgataccgct tgttcttctt ccttggtttc tgttaatttg ggtgtccaat ccatccaaat     1380

gggtgaatgt aagattgcta tttgcggtgg tgttaacgct ttgtttgatc catctacatc     1440

tgttgccttt tccaagttgg gtgttttgtc tgaaaatggc agatgcaact cttttagtga     1500

tcaagcctct ggttacgtta gatctgaagg tgctggtgtt gttgttttga agtctttgga     1560

acaagctaag ttggatggtg atagaatcta cggtgttatc aagggtgttt cctctaatga     1620

agatggtgct tctaatggtg acaagaactc tttgactact ccatcttgtg aagcccaatc     1680

cattaacatt tctaaggcta tggaaaaggc ctccttgtct ccatctgata tctattacat     1740

tgaagcccat ggtactggta ctccagttgg tgatccaatt gaagttaagg ccttgtccaa     1800

gatcttctcc aactctaaca acaaccagtt gaacaacttc tctaccgatg gtaatgataa     1860

cgatgatgat gatgacgata acacctctcc agaaccatta ttgattggct cattcaagtc     1920

caacatcggt catttggaat ctgctgctgg tattgcttct ttgattaagt gttgcttgat     1980

gttgaagaac aggatgttgg ttccatccat taactgctct aatttgaacc catccattcc     2040

attcgatcag tacaacatct ccgttatcag agaaatcaga caattcccaa ccgataagtt     2100

ggttaacatc ggtatcaatt ctttcggttt cggtggttct aactgccatt tgattattca     2160

agagtacaac aacaacttca agaacaactc taccatctgc aataacaaca acaacaacaa     2220

taacaacatc gactacttga tcccaatctc ctctaagact aagaagtcct tggataagta     2280

cttgattttg atcaagacca actccaacta ccacaaggat atttctttcg atgacttcgt     2340

caagttccaa atcaagtcta agcagtacaa cttgtccaac agaatgacta ccattgctaa     2400

cgattggaac tccttcatta agggttctaa cgaattccac aacttgatcg aatctaagga     2460

tggtgaaggt ggttcttcat cttctaacag aggtattgat tccgccaatc aaatcaacac     2520

tactactacc tctaccatca acgatatcga acctttgttg gttttcgttt tctgtggtca     2580

aggtccacaa tggaatggta tgattaagac cttgtacaac tccgagaacg ttttcaagaa     2640

caccgttgat catgttgaca gcatcttgta caagtacttc ggttactcca ttttgaacgt     2700

cttgtctaag atcgatgata acgacgattc catcaaccat ccaatagttg ctcaaccatc     2760

tttgttcttg ttgcaaattg gtttggtcga gttgtttaag tactggggta tctacccatc     2820

tatctctgtt ggtcattctt tcggtgaagt ctcttcttat tacttgtccg gtatcatctc     2880

tttggaaacc gcttgtaaaa tcgtctacgt cagatcctct aatcagaaca aaactatggg     2940

ttccggtaag atgttggttg tttctatggg ttttaagcaa tggaacgatc aattctctgc     3000

tgaatggtcc gatattgaaa ttgcttgtta caacgctcca gattccatag ttgttactgg     3060

taacgaagaa agattgaaag aattgtccat caagttgtcc gacgaatcca atcaaatttt     3120

caacaccttc ttgaggtccc catgttcttt tcattcttcc catcaagaag tcatcaaggg     3180

ttctatgttc gaagagttgt ctaacttgca atctactggt gaaaccgaaa tccctttgtt     3240

ctctactgtt actggtagac aagttttgtc tggtcatgtt actgctcaac acatctacga     3300

taatgttaga gaaccagtct tgttccaaaa gacgattgaa tccattacct cctacatcaa     3360

gtctcactac ccatccaatc aaaaggttat ctacgttgaa attgctccac acccaacctt     3420

gttttcattg atcaaaaagt ccatcccatc ctccaacaag aattcctctt ctgttttgtg     3480

tccattgaac agaaaagaaa actccaacaa ctcctacaag aagttcgttt ctcagttgta     3540

cttcaacggt gttaacgttg acttcaactt ccagttgaac tccatttgcg ataacgttaa     3600

caacgatcac catttgaaca acgtcaagca aaactccttc aaagagacta ccaattcctt     3660

gccaagatac caatgggaac aagatgaata ttggtccgaa ccattgatct ccagaaagaa     3720

tagattggaa ggtccaacta cttccttgtt gggtcataga attatctaca gcttcccagt     3780

tttccaatcc gttttggact tgcaatctga caactacaaa tacttgttgg accacttggt     3840

taacggtaag ccagtttttc caggtgctgg ttatttggat atcatcatcg aattcttcga     3900

ctaccaaaag cagcagttga attcctctga ttcctctaac tcctacatca tcaacgttga     3960

caagatccaa ttcttgaacc caattcactt gaccgaaaac aagttgcaaa ccttgcaatc     4020

ttctttcgaa cctatcgtta ctaagaagtc tgccttctct gttaacttct tcatcaagga     4080

taccgtcgag gatcaatcta aggttaagtc tatgtctgac gaaacttgga ctaacacttg     4140

taaggctacc atttccttgg aacaacaaca gccatctcca tcttctactt tgactttgtc     4200

taagaagcaa gacttgcaga tcttgagaaa cagatgcgat attagcaagc tagacaagtt     4260

tgagttgtac gacaagatct ctaagaattt gggcttgcag tacaactcct tgtttcaagt     4320

tgttgatacc atcgaaactg gtaaggattg ctcttttgct actttgtctt tgccagaaga     4380

tactttgttc accaccattt tgaacccatg cttgttggat aactgtttcc atggtttgtt     4440

gaccttgatc aacgaaaagg gttctttcgt tgtcgagtcc atttcttctg tttctatcta     4500

cttggagaac atcggttcct tcaatcaaac ttctgttggt aacgtccagt tctacttgta     4560

caccactatt tctaaagcca cctcctttag ttctgaaggt acttgtaagt tgttcaccaa     4620

ggatggttcc ttgattttgt ctatcggtaa gttcatcatc aagtccacca atccaaagtc     4680

tactaagacc aacgaaacta tcgaatctcc attggacgaa accttctcta ttgaatggca     4740

atctaaggat tctccaattc caaccccaca acaaatccaa caacaatctc cattgaactc     4800

taacccatcc ttcattagat ctaccatctt gaaggacatc cagttcgaac aatactgctc     4860

ctccattatc cacaaagaat tgatcaacca cgaaaagtac aagaaccagc aatccttcga     4920

tatcaactcc ttggaaaacc acttgaacga tgaccaattg atggaatcct tgtccatctc     4980

caaagaatac ttgagattct tcaccaggat catctccatc attaagcaat acccaaagat     5040

cttgaacgaa aaagagctaa aagaattgaa agaaatcatc gaattgaagt acccatccga     5100

agttcagttg ttggaattcg aagttatcga gaaggtgtcc atgattatcc caaagttgtt     5160

gttcgaaaac gacaagcaat cttccatgac cttgttccaa gataacttgt tgaccaggtt     5220

ctactccaat tctaactcta ccagattcta cttggaaagg gtttccgaaa tggtcttgga     5280

atctattaga ccaatcgtca gagaaaagag ggtgttcaga attttagaga tcggtgctcg     5340

tacaggctct ttgtctaatg ttgttttgac taagttgaac acctacttgt ccaccttgaa     5400

ttctaatggt ggttctggtt acaacatcat cattgagtac accttcaccg atatttccgc     5460

caacttcatt attggtgaaa tccaagaaac catgtgcaac ttgtacccaa acgttacttt     5520

caagttctcc gtcttggact tggagaaaga gattattaac tcctccgatt tcttgatggg     5580

tgattacgat atagttttga tggcctacgt tatccatgcc gtttctaaca ttaagttctc     5640

catcgaacag ttgtacaagt tgttgtctcc aagaggttgg ttgttgtgta ttgaacctaa     5700

gtccaacgtt gtgttctccg atttggtttt cggttgtttt aatcagtggt ggaactacta     5760

cgatgatatt agaactaccc actgctcctt gtctgaatct caatggaatc agttgttgtt     5820

gaaccagtcc ttgaacaacg aatcctcttc ttcttctaac tgttacggtg gtttctccaa     5880

cgtttctttt attggtggtg aaaaggatgt cgactcccat tctttcatat tgcactgcca     5940

aaaagaatcc atctcccaaa tgaagttagc caccactatt aacaacggtt tgtcatctgg     6000

ttccatcgtt atcgttttga actctcaaca attgaccaac atgaagtcct acccaaaggt     6060

tattgagtat attcaagagg ctacctcttt gtgcaagacc attgaaatta tcgattccaa     6120

ggacgtcttg aactctacca attcagtttt ggaaaagatc caaaagtcct tgttggtgtt     6180

ctgtttgttg ggttatgact tgttggagaa caactaccaa gaacagtctt tcgaatacgt     6240

taagttgttg aacttgatct ctactaccgc ctcttcatct aatgataaga aaccaccaaa     6300

ggtcttgttg atcaccaagc aatctgaaag aatctccagg tctttctact ccagatcctt     6360

gattggtatt tccagaacct ctatgaacga gtacccaaat ttgtccatta cctctatcga     6420

tttggatacc aacgactact cattgcagtc tttgttgaag ccaatcttca gcaactctaa     6480

gttttccgac aacgagttca tcttcaaaaa gggcttgatg ttcgtgtcca ggatctttaa     6540

gaacaagcag ttgctagaat cctccaacgc ttttgaaact gactcttcta acttgtactg     6600

taaggcctct tctgacttgt cttacaagta cgctattaag cagtctatgt tgaccgaaaa     6660

tcagatcgaa atcaaggttg aatgcgtcgg tattaacttc aaggacaacc tattctacaa     6720

gggcttgttg ccacaagaaa ttttcagaat gggtgacatc tacaatccac catatggttt     6780

ggaatgctct ggtgttatta ccagaattgg ttctaacgtc accgaatact cagttggtca     6840

aaatgttttt ggtttcgcca gacattcttt gggttctcat gttgttacca acaaggattt     6900

ggttatcttg aagccagata ccatctcatt ttctgaagct gcttctatcc cagttgttta     6960

ctgtactgct tggtactcct tgttcaacat tggtcagttg tctaacgaag aatccatcct     7020

aattcattct gctactggtg gtgtaggttt ggcttctttg aatttgttga aaatgaagaa     7080

tcagcaacag caaccattga ccaatgttta tgctactgtt ggctctaacg agaagaagaa     7140

gttcttgatc gataacttca acaacttgtt caaagaggac ggcgaaaaca ttttctctac     7200

cagagacaaa gaatactcca accagttgga atccaagatc gatgttattt tgaacacctt     7260

gtccggtgaa ttcgtcgaat ctaatttcaa gtccttgaga tccttcggta gattgattga     7320

tttgtctgct actcacgttt acgccaatca acaaattggt ctaggtaact tcaagttcga     7380

ccacttgtat tctgctgttg acttggaaag attgatcgac gaaaaaccta agttgttgca     7440

gtccatcttg caaagaatta ccaactctat cgtcaacggt tccttggaaa aaattccaat     7500

taccatcttc ccatccaccg aaactaagga tgctatcgaa ttattgtcca agagatccca     7560

tatcggtaaa gttgttgtag attgcaccga tatctctaag tgtaatcctg ttggtgatgt     7620

gatcaccaac ttctctatga gattgccaaa gccaaactac cagttgaatt tgaactccac     7680

cttgttgatt actggtcagt ctggtttgtc tatccctttg ttgaattggt tgttgtctaa     7740

gtctggtggt aacgttaaga acgttgtcat catttctaag tccaccatga agtggaagtt     7800

gcagactatg atttcccatt tcgtttccgg tttcggtatc cattttaact acgttcaagt     7860

cgacatctcc aactacgatg ctttgtctga agctattaag caattgccat ctgatttgcc     7920

accaatcacc tctgtttttc atttggctgc tatctacaac gatgttccaa tggatcaagt     7980

taccatgtct accgttgaat ctgttcataa ccctaaagtt ttgggtgccg ttaacttgca     8040

tagaatctct gtttcttttg gttggaagtt gaaccacttc gtcttgttct cttctattac     8100

tgctattacc ggttacccag accaatctat ctacaattct gccaactcta ttttggacgc     8160

tttgtccaac tttagaaggt ttatgggttt gccatccttc tccattaact tgggtccaat     8220

gaaggatgaa ggtaaggttt ctaccaacaa gagcatcaag aagctattca agtctagagg     8280

tttgccaagc ctatccttga acaagttatt tggtttgttg gaggtcgtca tcaacaaccc     8340

atctaatcat gttatcccat cccaattgat ttgctcccca atcgatttca agacctacat     8400

cgaatctttc tcaactatga ggccaaagtt gttacacttg caacctacca tttccaagca     8460

gcaatcttct atcattaacg attctaccaa ggcttcctcc aacatttcat tgcaagataa     8520

gatcacctcc aaggtgtctg atttgttgtc cattccaatc tccaagatca acttcgatca     8580

tccattgaaa cactacggct tggattcttt gttgaccgtt caattcaaat cctggatcga     8640

caaagaattc gaaaagaact tgttcaccca tatccaattg gccaccatct ctattaactc     8700

attcttggaa aaggtgaacg gcttgtctac aaacaataac aacaacaaca attccaacgt     8760

caagtcctct ccatccattg tcaaagaaga aatcgttacc ttggacaagg atcaacaacc     8820

attgctattg aaagaacacc agcacattat catctcccca gatattagaa tcaacaagcc     8880

aaagagggaa tccttgatta gaaccccaat cttgaacaaa ttcaaccaga tcaccgaatc     8940

cattatcact ccatctacac catctttgtc ccaatccgat gttttgaaaa ctccaccaat     9000

caagtctttg aacaacacta agaactccag cttgattaac accccaccaa ttcaatctgt     9060

ccaacaacat caaaagcaac aacaaaaggt ccaagtcatc caacaacagc aacaaccatt     9120

atccagattg tcctacaaga gcaacaacaa ctctttcgtt ttgggtatcg gtatttctgt     9180

tccaggtgaa cctatttccc aacaatcctt gaaagactcc atctccaatg acttttctga     9240

taaggctgaa actaacgaga aggtcaagag aatctttgag caatctcaaa tcaagaccag     9300

acacttggtt agagattaca ctaagccaga gaactccatc aagttcagac atttggaaac     9360

cattaccgat gtgaacaacc agttcaagaa agttgttcca gatttggctc aacaagcctg     9420

tttgagagct ttgaaagatt ggggtggtga taagggtgat attacccata tagtttctgt     9480

tacctccacc ggtattatca tcccagatgt taatttcaag ttgatcgact tgttgggctt     9540

gaacaaggat gttgaaagag tgtctttgaa cctaatgggt tgtttggctg gtttgagttc     9600

tttgagaact gctgcttctt tggctaaggc ttctccaaga aatagaattt tggttgtctg     9660

taccgaagtc tgctccttgc atttttctaa tactgatggt ggtgatcaaa tggtcgcctc     9720

ttctattttt gctgatggtt ctgctgctta cattattggt tgtaacccaa gaattgaaga     9780

aaccccatta tacgaagtca tgtgctccat taacagatct ttcccaaata ccgaaaacgc     9840

catggtttgg gatttggaaa aagaaggttg gaacttgggt ttggatgctt ctattccaat     9900

tgtcattggt tctggtattg aagccttcgt tgatactttg ttggataagg ctaagttgca     9960

aacttccact gctatttctg ctaaggattg cgaattcttg attcatactg gtggcaagtc    10020

catcttgatg aacatcgaaa attccttggg tatcgaccca aagcaaacta agaatacttg    10080

ggatgtttac catgcctacg gcaatatgtc atctgcctct gttattttcg ttatggatca    10140

tgccagaaag tccaagtctt tgccaactta ctcaatttct ttggcttttg gtccaggttt    10200

ggcttttgaa ggttgtttct tgaagaacgt cgtctgaaca gaagacggga gacactagca    10260

cacaacttta ccaggcaagg tatttgacgc tagcatgtgt ccaattcagt gtcatttatg    10320

attttttgta gtaggatata aatatataca gcgctccaaa tagtgcggtt gccccaaaaa    10380

caccacggaa cctcatctgt tctcgtactt tgttgtgaca aagtagctca ctgccttatt    10440

atcacatttt cattatgcaa cgcttcggaa aatacgatgt tgaaaatgcc tctagagatg    10500

aaaaacaatc gtaaaagggt cctgcgtaat tgaaacattt gatcagtatg cagtggcaca    10560

gaaacaacca ggaatactat agtcataggc aatacaaggt atatattggc tatgcagacc    10620

cctccagaaa gtaccgacgt caagttagat acacttaacg aacctagtgc acatttaatt    10680

gagaaaaatg tggctcttcc taaggacata ttccgttcgt acttgagtta ttggatctat    10740

gaaatcgctc gctatacacc agtcatgatt ttgtcgaaga catatgccca ctttgggaaa    10800

tagaaatggt cattttaagc tcaagtgaag cgaaaaaagg aggtatactc ctttacgcgt    10860

cacccaatct ggataggcac gtcaaactca ttaggtctca tcaagaacta gtgtagaaat    10920

gacgcttgaa ctccgaactt taaacaaagt tctgtttttg tttctgtttc tgtttcctgt    10980

tgctgtctct gtttctattt ttttcgtata gctctatttc ccttgtagat aaacatatat    11040

aagaatgcta ttatagaagc gtgtattttc ctccccctag cttcaacctg taattccctt    11100

cttagtaaag cgaactagaa ccagtttaat aggatataga                          11140


<210>  147
<211>  11637
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DiPKS-5

<400>  147
atgaacgcta atatatgggt ggctgcttca gatggtaatt tggaccgagt ggaacatatc       60

ctccgcgaga gtaaaggcgc catgaccccg caatccaagg acattaacgg ctacactcca      120

atgcatgctg ccgccgcata cggccacctg gatttgctga agaaaatgtg caatgagtac      180

aatggagaca ttaatgtgtt ggacaacgac ggcgataccc cgttgcacca tgtggaggat      240

gtggccactg ccaggttgat cgtggaagag ctgggtggag acttcactat caggaatgtg      300

gagggccaaa cgccatacga ctcgttcgtc gagaacggtg aagatggtga gctaatcgag      360

tacatgagga ttaagtccgg cgtggccgat gttcacggag tggacggcgt gcagggtgag      420

ggtgtcatcg acagcaaatt gctggaagag ttcaaggaca acgtgagata caccttggaa      480

aatgaccctg aggaaggagc cgatgaggcc actctgcaac gcaggaggca gttggaacag      540

atcattacgg gagacaacgc tgaggaggag ttggaaaggt acatccgtgc tatggtcaga      600

gagcagatgc tgggccaggg ctccatggcg ggttccgggg acgaaccaga ttccaagaga      660

agaaaataac gaaagcaaca ggcgcgttgg acttttaatt ttcgaggacc gcgaatcctt      720

acatcacacc caatccccca caagtgatcc cccacacacc atagcttcaa aatgtttcta      780

ctcctttttt actcttccag attttctcgg actccgcgca tcgccgtacc acttcaaaac      840

acccaagcac agcatactaa atttcccctc tttcttcctc tagggtgtcg ttaattaccc      900

gtactaaagg tttggaaaag aaaaaagaga ccgcctcgtt tctttttctt cgtcgaaaaa      960

ggcaataaaa atttttatca cgtttctttt tcttgaaaat tttttttttt gatttttttc     1020

tctttcgatg acctcccatt gatatttaag ttaataaacg gtcttcaatt tctcaagttt     1080

cagtttcatt tttcttgttc tattacaact ttttttactt cttgctcatt agaaagaaag     1140

catagcaatc taatctaagt tttaataaac aatgaacaag aactccaaaa tccagtcccc     1200

aaactcttct gatgttgctg ttattggtgt tggttttaga ttcccaggta actctaatga     1260

cccagaatct ttgtggaaca acttgttgga tggtttcgat gctattaccc aagtcccaaa     1320

agaaagatgg gctacttctt ttagagagat gggtttgatc aagaacaagt tcggtggttt     1380

cttgaaggat tctgaatgga agaatttcga ccctttgttc tttggtatcg gtccaaaaga     1440

agctccattc attgatccac aacaaaggtt gttgttgtcc atcgtttggg aatctttgga     1500

agatgcttac atcagaccag atgaattgag aggttctaac actggtgttt tcatcggtgt     1560

ttctaacaac gattacacca agttgggttt ccaagacaac tactctattt ctccatacac     1620

tatgaccggc tctaactctt cattgaactc caacagaatt tcctactgct tcgattttag     1680

aggtccatcc attactgttg ataccgcttg ttcttcttcc ttggtttctg ttaatttggg     1740

tgtccaatcc atccaaatgg gtgaatgtaa gattgctatt tgcggtggtg ttaacgcttt     1800

gtttgatcca tctacatctg ttgccttttc caagttgggt gttttgtctg aaaatggcag     1860

atgcaactct tttagtgatc aagcctctgg ttacgttaga tctgaaggtg ctggtgttgt     1920

tgttttgaag tctttggaac aagctaagtt ggatggtgat agaatctacg gtgttatcaa     1980

gggtgtttcc tctaatgaag atggtgcttc taatggtgac aagaactctt tgactactcc     2040

atcttgtgaa gcccaatcca ttaacatttc taaggctatg gaaaaggcct ccttgtctcc     2100

atctgatatc tattacattg aagcccatgg tactggtact ccagttggtg atccaattga     2160

agttaaggcc ttgtccaaga tcttctccaa ctctaacaac aaccagttga acaacttctc     2220

taccgatggt aatgataacg atgatgatga tgacgataac acctctccag aaccattatt     2280

gattggctca ttcaagtcca acatcggtca tttggaatct gctgctggta ttgcttcttt     2340

gattaagtgt tgcttgatgt tgaagaacag gatgttggtt ccatccatta actgctctaa     2400

tttgaaccca tccattccat tcgatcagta caacatctcc gttatcagag aaatcagaca     2460

attcccaacc gataagttgg ttaacatcgg tatcaattct ttcggtttcg gtggttctaa     2520

ctgccatttg attattcaag agtacaacaa caacttcaag aacaactcta ccatctgcaa     2580

taacaacaac aacaacaata acaacatcga ctacttgatc ccaatctcct ctaagactaa     2640

gaagtccttg gataagtact tgattttgat caagaccaac tccaactacc acaaggatat     2700

ttctttcgat gacttcgtca agttccaaat caagtctaag cagtacaact tgtccaacag     2760

aatgactacc attgctaacg attggaactc cttcattaag ggttctaacg aattccacaa     2820

cttgatcgaa tctaaggatg gtgaaggtgg ttcttcatct tctaacagag gtattgattc     2880

cgccaatcaa atcaacacta ctactacctc taccatcaac gatatcgaac ctttgttggt     2940

tttcgttttc tgtggtcaag gtccacaatg gaatggtatg attaagacct tgtacaactc     3000

cgagaacgtt ttcaagaaca ccgttgatca tgttgacagc atcttgtaca agtacttcgg     3060

ttactccatt ttgaacgtct tgtctaagat cgatgataac gacgattcca tcaaccatcc     3120

aatagttgct caaccatctt tgttcttgtt gcaaattggt ttggtcgagt tgtttaagta     3180

ctggggtatc tacccatcta tctctgttgg tcattctttc ggtgaagtct cttcttatta     3240

cttgtccggt atcatctctt tggaaaccgc ttgtaaaatc gtctacgtca gatcctctaa     3300

tcagaacaaa actatgggtt ccggtaagat gttggttgtt tctatgggtt ttaagcaatg     3360

gaacgatcaa ttctctgctg aatggtccga tattgaaatt gcttgttaca acgctccaga     3420

ttccatagtt gttactggta acgaagaaag attgaaagaa ttgtccatca agttgtccga     3480

cgaatccaat caaattttca acaccttctt gaggtcccca tgttcttttc attcttccca     3540

tcaagaagtc atcaagggtt ctatgttcga agagttgtct aacttgcaat ctactggtga     3600

aaccgaaatc cctttgttct ctactgttac tggtagacaa gttttgtctg gtcatgttac     3660

tgctcaacac atctacgata atgttagaga accagtcttg ttccaaaaga cgattgaatc     3720

cattacctcc tacatcaagt ctcactaccc atccaatcaa aaggttatct acgttgaaat     3780

tgctccacac ccaaccttgt tttcattgat caaaaagtcc atcccatcct ccaacaagaa     3840

ttcctcttct gttttgtgtc cattgaacag aaaagaaaac tccaacaact cctacaagaa     3900

gttcgtttct cagttgtact tcaacggtgt taacgttgac ttcaacttcc agttgaactc     3960

catttgcgat aacgttaaca acgatcacca tttgaacaac gtcaagcaaa actccttcaa     4020

agagactacc aattccttgc caagatacca atgggaacaa gatgaatatt ggtccgaacc     4080

attgatctcc agaaagaata gattggaagg tccaactact tccttgttgg gtcatagaat     4140

tatctacagc ttcccagttt tccaatccgt tttggacttg caatctgaca actacaaata     4200

cttgttggac cacttggtta acggtaagcc agtttttcca ggtgctggtt atttggatat     4260

catcatcgaa ttcttcgact accaaaagca gcagttgaat tcctctgatt cctctaactc     4320

ctacatcatc aacgttgaca agatccaatt cttgaaccca attcacttga ccgaaaacaa     4380

gttgcaaacc ttgcaatctt ctttcgaacc tatcgttact aagaagtctg ccttctctgt     4440

taacttcttc atcaaggata ccgtcgagga tcaatctaag gttaagtcta tgtctgacga     4500

aacttggact aacacttgta aggctaccat ttccttggaa caacaacagc catctccatc     4560

ttctactttg actttgtcta agaagcaaga cttgcagatc ttgagaaaca gatgcgatat     4620

tagcaagcta gacaagtttg agttgtacga caagatctct aagaatttgg gcttgcagta     4680

caactccttg tttcaagttg ttgataccat cgaaactggt aaggattgct cttttgctac     4740

tttgtctttg ccagaagata ctttgttcac caccattttg aacccatgct tgttggataa     4800

ctgtttccat ggtttgttga ccttgatcaa cgaaaagggt tctttcgttg tcgagtccat     4860

ttcttctgtt tctatctact tggagaacat cggttccttc aatcaaactt ctgttggtaa     4920

cgtccagttc tacttgtaca ccactatttc taaagccacc tcctttagtt ctgaaggtac     4980

ttgtaagttg ttcaccaagg atggttcctt gattttgtct atcggtaagt tcatcatcaa     5040

gtccaccaat ccaaagtcta ctaagaccaa cgaaactatc gaatctccat tggacgaaac     5100

cttctctatt gaatggcaat ctaaggattc tccaattcca accccacaac aaatccaaca     5160

acaatctcca ttgaactcta acccatcctt cattagatct accatcttga aggacatcca     5220

gttcgaacaa tactgctcct ccattatcca caaagaattg atcaaccacg aaaagtacaa     5280

gaaccagcaa tccttcgata tcaactcctt ggaaaaccac ttgaacgatg accaattgat     5340

ggaatccttg tccatctcca aagaatactt gagattcttc accaggatca tctccatcat     5400

taagcaatac ccaaagatct tgaacgaaaa agagctaaaa gaattgaaag aaatcatcga     5460

attgaagtac ccatccgaag ttcagttgtt ggaattcgaa gttatcgaga aggtgtccat     5520

gattatccca aagttgttgt tcgaaaacga caagcaatct tccatgacct tgttccaaga     5580

taacttgttg accaggttct actccaattc taactctacc agattctact tggaaagggt     5640

ttccgaaatg gtcttggaat ctattagacc aatcgtcaga gaaaagaggg tgttcagaat     5700

tttagagatc ggtgctcgta caggctcttt gtctaatgtt gttttgacta agttgaacac     5760

ctacttgtcc accttgaatt ctaatggtgg ttctggttac aacatcatca ttgagtacac     5820

cttcaccgat atttccgcca acttcattat tggtgaaatc caagaaacca tgtgcaactt     5880

gtacccaaac gttactttca agttctccgt cttggacttg gagaaagaga ttattaactc     5940

ctccgatttc ttgatgggtg attacgatat agttttgatg gcctacgtta tccatgccgt     6000

ttctaacatt aagttctcca tcgaacagtt gtacaagttg ttgtctccaa gaggttggtt     6060

gttgtgtatt gaacctaagt ccaacgttgt gttctccgat ttggttttcg gttgttttaa     6120

tcagtggtgg aactactacg atgatattag aactacccac tgctccttgt ctgaatctca     6180

atggaatcag ttgttgttga accagtcctt gaacaacgaa tcctcttctt cttctaactg     6240

ttacggtggt ttctccaacg tttcttttat tggtggtgaa aaggatgtcg actcccattc     6300

tttcatattg cactgccaaa aagaatccat ctcccaaatg aagttagcca ccactattaa     6360

caacggtttg tcatctggtt ccatcgttat cgttttgaac tctcaacaat tgaccaacat     6420

gaagtcctac ccaaaggtta ttgagtatat tcaagaggct acctctttgt gcaagaccat     6480

tgaaattatc gattccaagg acgtcttgaa ctctaccaat tcagttttgg aaaagatcca     6540

aaagtccttg ttggtgttct gtttgttggg ttatgacttg ttggagaaca actaccaaga     6600

acagtctttc gaatacgtta agttgttgaa cttgatctct actaccgcct cttcatctaa     6660

tgataagaaa ccaccaaagg tcttgttgat caccaagcaa tctgaaagaa tctccaggtc     6720

tttctactcc agatccttga ttggtatttc cagaacctct atgaacgagt acccaaattt     6780

gtccattacc tctatcgatt tggataccaa cgactactca ttgcagtctt tgttgaagcc     6840

aatcttcagc aactctaagt tttccgacaa cgagttcatc ttcaaaaagg gcttgatgtt     6900

cgtgtccagg atctttaaga acaagcagtt gctagaatcc tccaacgctt ttgaaactga     6960

ctcttctaac ttgtactgta aggcctcttc tgacttgtct tacaagtacg ctattaagca     7020

gtctatgttg accgaaaatc agatcgaaat caaggttgaa tgcgtcggta ttaacttcaa     7080

ggacaaccta ttctacaagg gcttgttgcc acaagaaatt ttcagaatgg gtgacatcta     7140

caatccacca tatggtttgg aatgctctgg tgttattacc agaattggtt ctaacgtcac     7200

cgaatactca gttggtcaaa atgtttttgg tttcgccaga cattctttgg gttctcatgt     7260

tgttaccaac aaggatttgg ttatcttgaa gccagatacc atctcatttt ctgaagctgc     7320

ttctatccca gttgtttact gtactgcttg gtactccttg ttcaacattg gtcagttgtc     7380

taacgaagaa tccatcctaa ttcattctgc tactggtggt gtaggtttgg cttctttgaa     7440

tttgttgaaa atgaagaatc agcaacagca accattgacc aatgtttatg ctactgttgg     7500

ctctaacgag aagaagaagt tcttgatcga taacttcaac aacttgttca aagaggacgg     7560

cgaaaacatt ttctctacca gagacaaaga atactccaac cagttggaat ccaagatcga     7620

tgttattttg aacaccttgt ccggtgaatt cgtcgaatct aatttcaagt ccttgagatc     7680

cttcggtaga ttgattgatt tgtctgctac tcacgtttac gccaatcaac aaattggtct     7740

aggtaacttc aagttcgacc acttgtattc tgctgttgac ttggaaagat tgatcgacga     7800

aaaacctaag ttgttgcagt ccatcttgca aagaattacc aactctatcg tcaacggttc     7860

cttggaaaaa attccaatta ccatcttccc atccaccgaa actaaggatg ctatcgaatt     7920

attgtccaag agatcccata tcggtaaagt tgttgtagat tgcaccgata tctctaagtg     7980

taatcctgtt ggtgatgtga tcaccaactt ctctatgaga ttgccaaagc caaactacca     8040

gttgaatttg aactccacct tgttgattac tggtcagtct ggtttgtcta tccctttgtt     8100

gaattggttg ttgtctaagt ctggtggtaa cgttaagaac gttgtcatca tttctaagtc     8160

caccatgaag tggaagttgc agactatgat ttcccatttc gtttccggtt tcggtatcca     8220

ttttaactac gttcaagtcg acatctccaa ctacgatgct ttgtctgaag ctattaagca     8280

attgccatct gatttgccac caatcacctc tgtttttcat ttggctgcta tctacaacga     8340

tgttccaatg gatcaagtta ccatgtctac cgttgaatct gttcataacc ctaaagtttt     8400

gggtgccgtt aacttgcata gaatctctgt ttcttttggt tggaagttga accacttcgt     8460

cttgttctct tctattactg ctattaccgg ttacccagac caatctatct acaattctgc     8520

caactctatt ttggacgctt tgtccaactt tagaaggttt atgggtttgc catccttctc     8580

cattaacttg ggtccaatga aggatgaagg taaggtttct accaacaaga gcatcaagaa     8640

gctattcaag tctagaggtt tgccaagcct atccttgaac aagttatttg gtttgttgga     8700

ggtcgtcatc aacaacccat ctaatcatgt tatcccatcc caattgattt gctccccaat     8760

cgatttcaag acctacatcg aatctttctc aactatgagg ccaaagttgt tacacttgca     8820

acctaccatt tccaagcagc aatcttctat cattaacgat tctaccaagg cttcctccaa     8880

catttcattg caagataaga tcacctccaa ggtgtctgat ttgttgtcca ttccaatctc     8940

caagatcaac ttcgatcatc cattgaaaca ctacggcttg gattctttgt tgaccgttca     9000

attcaaatcc tggatcgaca aagaattcga aaagaacttg ttcacccata tccaattggc     9060

caccatctct attaactcat tcttggaaaa ggtgaacggc ttgtctacaa acaataacaa     9120

caacaacaat tccaacgtca agtcctctcc atccattgtc aaagaagaaa tcgttacctt     9180

ggacaaggat caacaaccat tgctattgaa agaacaccag cacattatca tctccccaga     9240

tattagaatc aacaagccaa agagggaatc cttgattaga accccaatct tgaacaaatt     9300

caaccagatc accgaatcca ttatcactcc atctacacca tctttgtccc aatccgatgt     9360

tttgaaaact ccaccaatca agtctttgaa caacactaag aactccagct tgattaacac     9420

cccaccaatt caatctgtcc aacaacatca aaagcaacaa caaaaggtcc aagtcatcca     9480

acaacagcaa caaccattat ccagattgtc ctacaagagc aacaacaact ctttcgtttt     9540

gggtatcggt atttctgttc caggtgaacc tatttcccaa caatccttga aagactccat     9600

ctccaatgac ttttctgata aggctgaaac taacgagaag gtcaagagaa tctttgagca     9660

atctcaaatc aagaccagac acttggttag agattacact aagccagaga actccatcaa     9720

gttcagacat ttggaaacca ttaccgatgt gaacaaccag ttcaagaaag ttgttccaga     9780

tttggctcaa caagcctgtt tgagagcttt gaaagattgg ggtggtgata agggtgatat     9840

tacccatata gtttctgtta cctccaccgg tattatcatc ccagatgtta atttcaagtt     9900

gatcgacttg ttgggcttga acaaggatgt tgaaagagtg tctttgaacc taatgggttg     9960

tttggctggt ttgagttctt tgagaactgc tgcttctttg gctaaggctt ctccaagaaa    10020

tagaattttg gttgtctgta ccgaagtctg ctccttgcat ttttctaata ctgatggtgg    10080

tgatcaaatg gtcgcctctt ctatttttgc tgatggttct gctgcttaca ttattggttg    10140

taacccaaga attgaagaaa ccccattata cgaagtcatg tgctccatta acagatcttt    10200

cccaaatacc gaaaacgcca tggtttggga tttggaaaaa gaaggttgga acttgggttt    10260

ggatgcttct attccaattg tcattggttc tggtattgaa gccttcgttg atactttgtt    10320

ggataaggct aagttgcaaa cttccactgc tatttctgct aaggattgcg aattcttgat    10380

tcatactggt ggcaagtcca tcttgatgaa catcgaaaat tccttgggta tcgacccaaa    10440

gcaaactaag aatacttggg atgtttacca tgcctacggc aatatgtcat ctgcctctgt    10500

tattttcgtt atggatcatg ccagaaagtc caagtctttg ccaacttact caatttcttt    10560

ggcttttggt ccaggtttgg cttttgaagg ttgtttcttg aagaacgtcg tctgaacaga    10620

agacgggaga cactagcaca caactttacc aggcaaggta tttgacgcta gcatgtgtcc    10680

aattcagtgt catttatgat tttttgtagt aggatataaa tatatacagc gctccaaata    10740

gtgcggttgc cccaaaaaca ccacggaacc tcatctgttc tcgtactttg ttgtgacaaa    10800

gtagctcact gccttattat cacattttca ttatgcaacg cttcggaaaa tacgatgttg    10860

aaaatgcctc tagagatgaa aaacaatcgt aaaagggtcc tgcgtaattg aaacatttga    10920

tcagtatgca gtggcacaga aacaaccagg aatactatag tcataggcaa tacaaggtat    10980

atattggcta tgcagacccc tccagaaagt accgacgtca agttagatac acttaacgaa    11040

cctagtgcac atttaattga gaaaaatgtg gctcttccta aggacatatt ccgttcgtac    11100

ttgagttatt ggatctatga aatcgctcgc tatacaccag tcatgatttt gtctaataga    11160

cgttcttaca aggtaaaatt tcaccgcgtt tttaaataga atgaaaaaaa cgttgtagag    11220

tgaaagaaaa gcaacaaata tacagttcac aaggcagctt cgtatagtaa tacagcacga    11280

aaaacagctc atagaaatgg taacacagac caatccggtc cctgttacat atccaacgga    11340

tgcttatatc cccacgtatc tgcccgatga taaggtctcc aatctggcag atttgaaaaa    11400

attgatagaa atggattcca gactagattt gtatctgaca agaaggaggc tggatacgtc    11460

catcaattta cctacaaaca ccaagaccaa ggaccatccc cccaataaag agatgctgag    11520

gatttacgtc tacaacacta cggaaagcag ccctcgcagc gattctggca ccccagcgga    11580

ctcaggcaag actacatgga cactgagaat agaaggtaag cttctgcacg agtccgc       11637


<210>  148
<211>  7114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDH

<400>  148
caccggagct tggatatgat aaacgaaata ttcttgaatc gtgagatcgc ctgttttcaa       60

aaccgttgga ggcagaaaca attttgtcac aagatgggca ttctacccca tccttgctgt      120

attattgtag tctcgctttc ttttatgctg gacaaatgag actactgcac atttttatac      180

gttcttggtt ttttttaaag gtgtggtttc ggcattatcc tgccgcacgt ttcttggata      240

attcatcctg attctctatt ttaaacgctt cagcctatca ggatttggtt ttgatacata      300

ctgcaagagt gtatctcggg aacagtcatt tattccgcaa caaacttaat tgcggaacgc      360

gttaggcgat ttctagcata tatcaaatac cgttcgcgat ttcttctggg ttcgtctctt      420

ttcttttaaa tacttattaa cgtactcaaa caactacact tcgttgtatc tcagaatgag      480

atccctcagt atgacaatac atcattctaa acgttcgtaa aacacatatg aaacaacttt      540

ataacaaagc gaacaaaatg ggcaacatga gatgaaactc cgcgtccctt agctgaacta      600

cccaaacgta cgaatgcctg aacaattagt ttagatccga gattccgcgc ttccatcatt      660

tagtataatc catattttat ataatatata ggataagtaa cagcccgcga aaaacaacaa      720

ataatcataa aaattttaga actagacata tcgagtttat cattatcaat actgccattt      780

caaagaatac gtaaataatt aatagtagtg attttcctaa ctttatttag tcaaaaaatt      840

agccttttaa ttctgctgta acccgtacat gcccaaaata gggggcgggt tacacagaat      900

atataacatc gtaggtgtct gggtgaacag tttattcctg gcatccacta aatataatgg      960

agcccgcttt ttaagctggc atccagaaaa aaaaagaatc ccagcaccaa aatattgttt     1020

tcttcaccaa ccatcagttc ataggtccat tctcttagcg caactacaga gaacaggggc     1080

acaaacaggc aaaaaacggg cacaacctca atggagtgat gcaacctgcc tggagtaaat     1140

gatgacacaa ggcaattgac ccacgcatgt atctatctca ttttcttaca ccttctatta     1200

ccttctgctc tctctgattt ggaaaaagct gaaaaaaaag gttgaaacca gttccctgaa     1260

attattcccc tacttgacta ataagtatat aaagacggta ggtattgatt gtaattctgt     1320

aaatctattt cttaaacttc ttaaattcta cttttatagt tagtcttttt tttagtttta     1380

aaacaccaag aacttagttt cgactagaaa atttattata aaaggaagag aaataattaa     1440

acaatgacta agctacactt tgacactgct gaaccagtca agatcacact tccaaatggt     1500

ttgacatacg agcaaccaac cggtctattc attaacaaca agtttatgaa agctcaagac     1560

ggtaagacct atcccgtcga agatccttcc actgaaaaca ccgtttgtga ggtctcttct     1620

gccaccactg aagatgttga atatgctatc gaatgtgccg accgtgcttt ccacgacact     1680

gaatgggcta cccaagaccc aagagaaaga ggccgtctac taagtaagtt ggctgacgaa     1740

ttggaaagcc aaattgactt ggtttcttcc attgaagctt tggacaatgg taaaactttg     1800

gccttagccc gtggggatgt taccattgca atcaactgtc taagagatgc tgctgcctat     1860

gccgacaaag tcaacggtag aacaatcaac accggtgacg gctacatgaa cttcaccacc     1920

ttagagccaa tcggtgtctg tggtcaaatt attccatgga actttccaat aatgatgttg     1980

gcttggaaga tcgccccagc attggccatg ggtaacgtct gtatcttgaa acccgctgct     2040

gtcacacctt taaatgccct atactttgct tctttatgta agaaggttgg tattccagct     2100

ggtgtcgtca acatcgttcc aggtcctggt agaactgttg gtgctgcttt gaccaacgac     2160

ccaagaatca gaaagctggc ttttaccggt tctacagaag tcggtaagag tgttgctgtc     2220

gactcttctg aatctaactt gaagaaaatc actttggaac taggtggtaa gtccgcccat     2280

ttggtctttg acgatgctaa cattaagaag actttaccaa atctagtaaa cggtattttc     2340

aagaacgctg gtcaaatttg ttcctctggt tctagaattt acgttcaaga aggtatttac     2400

gacgaactat tggctgcttt caaggcttac ttggaaaccg aaatcaaagt tggtaatcca     2460

tttgacaagg ctaacttcca aggtgctatc actaaccgtc aacaattcga cacaattatg     2520

aactacatcg atatcggtaa gaaagaaggc gccaagatct taactggtgg cgaaaaagtt     2580

ggtgacaagg gttacttcat cagaccaacc gttttctacg atgttaatga agacatgaga     2640

attgttaagg aagaaatttt tggaccagtt gtcactgtcg caaagttcaa gactttagaa     2700

gaaggtgtcg aaatggctaa cagctctgaa ttcggtctag gttctatggg tatcgaaaca     2760

gaatctttga gcacaggttt gaaggtggcc aagatgttga aggccggtac cgtctggatc     2820

aacacataca acgattttga ctccagagtt ccattcggtg gtgttaagca atctggttac     2880

ggtagagaaa tgggtgaaga agtctaccat gcatacactg aagtaaaagc tgtcagaatt     2940

aagttgtaaa gacataaaac tgaaacaaca ccaattaata atagactttt ggacttcttc     3000

gccagaggtt tggtcaagtc tccaatcaag gttgtcggct tgtctacctt gccagaaatt     3060

tacgaaaaga tggaaaaggg tcaaatcgtt ggtagatacg ttgttgacac ttctaaataa     3120

gcgaatttct tatgatttat gatttttatt attaaataag ttataaaaaa aataagtgta     3180

tacaaatttt aaagtgactc ttaggtttta aaacgaaaat tcttattctt gagtaactct     3240

ttcctgtagg tcaggttgct ttctcaggta tagcatgagg tcgctcttat tgaccacacc     3300

tctaccggca tggcttaaat aacatactca tcactaaaca ttcttaacaa tcaaagcaac     3360

aggcgcgttg gacttttaat tttcgaggac cgcgaatcct tacatcacac ccaatccccc     3420

acaagtgatc ccccacacac catagcttca aaatgtttct actccttttt tactcttcca     3480

gattttctcg gactccgcgc atcgccgtac cacttcaaaa cacccaagca cagcatacta     3540

aatttcccct ctttcttcct ctagggtgtc gttaattacc cgtactaaag gtttggaaaa     3600

gaaaaaagag accgcctcgt ttctttttct tcgtcgaaaa aggcaataaa aatttttatc     3660

acgtttcttt ttcttgaaaa tttttttttt tgattttttt ctctttcgat gacctcccat     3720

tgatatttaa gttaataaac ggtcttcaat ttctcaagtt tcagtttcat ttttcttgtt     3780

ctattacaac tttttttact tcttgctcat tagaaagaaa gcatagcaat ctaatctaag     3840

ttttaataca tctaccagtc aacagccaac aattaactaa ttaaacaatg tcccaaactc     3900

ataagcacgc tattccagct aatattgctg atagatgctt gatcaaccca gaacagtacg     3960

aaactaagta caagcaatcc atcaacgatc cagatacttt ttggggtgaa caaggtaaga     4020

ttttggattg gattacccca taccaaaagg tcaagaatac ttcttttgct ccaggcaacg     4080

tttccattaa gtggtatgaa gatggtactt tgaacttggc tgctaactgt ttggatagac     4140

acttgcaaga aaacggtgat agaaccgcta ttatttggga aggtgatgat acctcccaat     4200

ccaaacatat ctcttacaga gaattgcaca gagatgtctg tagattcgct aacactttgt     4260

tggatttggg catcaaaaag ggtgatgttg ttgctatcta tatgccaatg gttcctgaag     4320

ctgctgttgc tatgttggct tgtgctagaa ttggtgctgt tcattctgtt attttcggtg     4380

gtttttcacc agaagctgtt gccggtagaa ttatcgattc ttcatccaga ttggttatca     4440

ccgctgatga aggtgttaga gctggtagat ctattccatt gaaaaagaac gttgatgacg     4500

ccttgaagaa cccaaatgtt acttctgttg aacacgtcat cgttttgaag agaactggtt     4560

ctgatatcga ttggcaagag ggtagagatt tgtggtggag agatttgatt gaaaaggctt     4620

ctccagaaca tcaaccagaa gctatgaacg ctgaagatcc tttgtttatc ttgtacactt     4680

ctggttctac tggtaagcca aaaggtgttt tacacactac tggtggttat ttggtttacg     4740

ctgctactac tttcaagtac gttttcgatt atcacccagg tgatatctat tggtgtactg     4800

ctgatgttgg ttgggttact ggtcattctt atttgttgta tggtccattg gcttgtggtg     4860

ctactacatt gatgtttgaa ggtgttccaa attggccaac tccagctaga atgtgtcaag     4920

ttgttgacaa acaccaagtc aacatcttgt atactgctcc aactgctatt agagctttga     4980

tggctgaagg tgataaggct attgaaggta ctgatagatc ctccttgaga atcttgggtt     5040

ctgttggtga acctattaac cctgaagcct gggaatggta ttggaagaaa attggtaaag     5100

aaaagtgccc agttgttgat acttggtggc aaactgaaac tggtggtttt atgattactc     5160

cattgccagg tgctattgaa ttgaaagctg gttctgctac tagaccattt tttggtgttc     5220

aaccagcttt ggttgataac gaaggtcatc cacaagaagg tgctactgaa ggtaatttgg     5280

ttattactga ttcttggcca ggtcaagcta gaactttgtt tggtgatcac gaaagattcg     5340

aacagactta cttctctacc ttcaagaaca tgtacttctc tggtgatggt gctagaagag     5400

atgaagatgg ttactattgg attaccggta gagttgatga tgtcttgaat gtttctggtc     5460

acagattagg tactgccgaa attgaatctg ctttggttgc tcatccaaag attgctgaag     5520

ctgcagttgt tggtattcca catgctatta agggtcaagc tatctacgct tacgttactt     5580

tgaatcatgg tgaagaacca tctccagaat tatacgctga agttagaaac tgggtcagaa     5640

aagaaattgg tccattagct accccagatg ttttacattg gactgattct ttgccaaaga     5700

ccagatcagg taagatcatg agaagaatct tgagaaagat tgctgctggt gatacttcta     5760

acttgggtga tacttcaaca ttagctgatc caggtgttgt tgaaaagcct ttggaagaaa     5820

aacaagctat tgccatgcca tcctaataat taaatactat tttcaaaatt ctacttaaaa     5880

ataacagaag acgggagaca ctagcacaca actttaccag gcaaggtatt tgacgctagc     5940

atgtgtccaa ttcagtgtca tttatgattt tttgtagtag gatataaata tatacagcgc     6000

tccaaatagt gcggttgccc caaaaacacc acggaacctc atctgttctc gtactttgtt     6060

gtgacaaagt agctcactgc cttattatca cattttcatt atgcaacgct tcggaaaata     6120

cgatgttgaa aatgcctcta gagatgaaaa acaatcgtaa aagggtcctg cgtaattgaa     6180

acatttgatc agtatgcagt ggcacagaaa caaccaggaa tactatagtc ataggcaata     6240

caaggtatat attggctatg cagacccctc cagaaagtac cgacgtcaag ttagatacac     6300

ttaacgaacc tagtgcacat ttaattgaga aaaatgtggc tcttcctaag gacatattcc     6360

gttcgtactt gagttattgg atctatgaaa tcgctcgcta tacaccagtc atgattttgt     6420

cattgcgaag actatactga tatatgaatt taaactagag cggaccaact atcatccgct     6480

aattactgac attaccaaat gagatctgtg aatgggcaag ataaaaaaca aaaattgaaa     6540

tgtttgacgt tatgtaaaac tattaattcc ttcgctttcg gcggtcacag aatttgcgtg     6600

tagctgactc ttgttcaatc aatatcattt gttactttat ttgaaagtct gtattactgc     6660

gcctattgtc atccgtacca aagaacgtca aaaagaaaca agataatttt tgtgcttaca     6720

ccatttatag atcactgagc ccagaatatc gctggagctc agtgtaagtg gcatgaacac     6780

aactctgact gatcgcacat attgccgtta tcataaatac tagttgtact tgtcaatgcg     6840

acgaatggca tcatgcctat tattacgttc ctctttttcc gtttcatgtt tccagaatgc     6900

tattgaatct aacacttcaa ttataaaaaa gaataaatcc gcaataattt taggctaatt     6960

gttgtactgt caagcgaacc taatggttaa aattcagagg aaccttcgac gtagtctgat     7020

cgctacttct atatcttatg ttcccagtca atcaaaagtt gatactataa tagctgccat     7080

ttatacctgt tagttatggc gatcgtttat cacg                                 7114


<210>  149
<211>  3256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Maf1

<400>  149
aatgatttaa gcgtgcgtga agataacact acaatccatt ttaaagcaac atccacattg       60

agtgtataca ccacaaaggt tttttcaggg cgtttttctc gccactttat gttgaccaaa      120

attattaatg gaacttacaa cgtttccaaa agttagttaa atacatacgt ctatttacta      180

agcaagaaat atatcatgac aagcccaaat attatattgt tatgtttaca aaaaaaaaat      240

ggctatatac atcaagtctg gaggcttttt ataacaagca agtggggtaa cttagacata      300

agattgactt ctttgaattc aacaaaaata catacttttg atgatttcaa tggtagaagc      360

ataaacaaca aataatcata aaaattttag aactagacat aaagcaacag gcgcgttgga      420

cttttaattt tcgaggaccg cgaatcctta catcacaccc aatcccccac aagtgatccc      480

ccacacacca tagcttcaaa atgtttctac tcctttttta ctcttccaga ttttctcgga      540

ctccgcgcat cgccgtacca cttcaaaaca cccaagcaca gcatactaaa tttcccctct      600

ttcttcctct agggtgtcgt taattacccg tactaaaggt ttggaaaaga aaaaagagac      660

cgcctcgttt ctttttcttc gtcgaaaaag gcaataaaaa tttttatcac gtttcttttt      720

cttgaaaatt tttttttttg atttttttct ctttcgatga cctcccattg atatttaagt      780

taataaacgg tcttcaattt ctcaagtttc agtttcattt ttcttgttct attacaactt      840

tttttacttc ttgctcatta gaaagaaagc atagcaatct aatctaagtt ttaatctaga      900

aaatttatta taaaaggaag agaaataatt aaacaatgaa atttattgat gagctagata      960

tagagagagt gaatcaaact ctcaatttcg agacaaatga ctgtaaaatc gtgggcagtt     1020

gcgatatttt cacaacaaag gcggttgcat cagatagaaa attatataaa actattgatc     1080

agcatttgga tactatttta caggaaaatg agaattacaa tgctaccctt cagcaacagc     1140

tagctgctcc cgaaacaaac caatcaccct gctcgtcgcc attttattct aataggaggg     1200

atagcaactc tttttgggag caaaagagaa gaatatcttt tagtgaatac aatagcaata     1260

ataacactaa caacagtaat ggcaatagca gtaataacaa taactattct ggacctaatg     1320

gttcttctcc agcaactttt cccaaaagtg ccaagctaaa tgaccaaaat ttaaaagaat     1380

tagtctcgaa ttacgattct ggctctatga gctcatcgtc tcttgattct tcttctaaga     1440

atgatgagag gataagaaga aggagcagta gcagtattag cagtttcaaa agtggtaaat     1500

catcgaacaa taattacagt tctggtacag caaccaacaa tgttaacaaa agaagaaaat     1560

cttcgataaa cgaaaggcca agcaatttaa gtttgggtcc gtttggtccc ataaacgaac     1620

cgtcaagccg caaaatattt gcttatctga ttgctatcct caacgcttct tatcctgacc     1680

atgatttttc atcggttgag ccaacggatt ttgtcaaaac atcattgaaa acttttattt     1740

ccaaatttga aaacacctta tattctcttg gtagacaacc agaggaatgg gtctgggagg     1800

taattaattc tcacatgact ctttctgatt gcgtcctttt tcaatattca ccttcaaact     1860

cttttttgga agatgagcct ggctatcttt ggaatcttat aggttttctt tacaacagga     1920

aaaggaaaag agtggcttac ctttacttga tttgctcgcg tctaaattcg agtacaggcg     1980

aagtggaaga tgccttggca aaaaaacctc agggaaagct tataatagat gatggctcaa     2040

atgaatacga aggagaatac gatttcactt atgatgagaa tgtaatagat gataaatcag     2100

atcaagaaga atccctacag tagagacata aaactgaaac aacaccaatt aataatagac     2160

tttacagaag acgggagaca ctagcacaca actttaccag gcaaggtatt tgacgctagc     2220

atgtgtccaa ttcagtgtca tttatgattt tttgtagtag gatataaata tatacagcgc     2280

tccaaatagt gcggttgccc caaaaacacc acggaacctc atctgttctc gtactttgtt     2340

gtgacaaagt agctcactgc cttattatca cattttcatt atgcaacgct tcggaaaata     2400

cgatgttgaa aatgcctcta gagatgaaaa acaatcgtaa aagggtcctg cgtaattgaa     2460

acatttgatc agtatgcagt ggcacagaaa caaccaggaa tactatagtc ataggcaata     2520

caaggtatat attggctatg cagacccctc cagaaagtac cgacgtcaag ttagatacac     2580

ttaacgaacc tagtgcacat ttaattgaga aaaatgtggc tcttcctaag gacatattcc     2640

gttcgtactt gagttattgg atctatgaaa tcgctcgcta tacaccagtc atgattttgt     2700

ccttaaataa catactcatc actaaacatt cttaacaatc agaaaacaac gcgtcatgaa     2760

aaagagttac tgaaccttca gatcctactt attgtaatgc ttcgcgacat ccaatccatt     2820

taataatcaa tttaaaacta gagttggtag agttccttgt tgaacgtgat aacccaaaag     2880

cataatacga gtaatgtttc agtattgcta ttatatgttt acacaaggaa aacatataat     2940

aacaaacctc taatccggta gtacttaaga aactatagtt tctatgtaca aaaaggtaac     3000

tatgtaattc ttacatttac ataacatata gaagggtcca ataaacttac taaacttact     3060

accttgttgt atataggcta gatcgtaatc cactacgtca acataaaaaa aacttaagga     3120

gtttgaattt tatgtacaaa cagattgtta aaatataata taagattatg gaaacgaact     3180

tgctctaaaa aaaatttaaa gttttataaa atcctcgcac tatcgctgtt atacatgatg     3240

tccccaaagc gtgtac                                                     3256


<210>  150
<211>  4538
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Erg20K197E

<400>  150
ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg       60

acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc      120

tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc      180

ctttctccct tcgggaagcg tggcgctttc tcaatgctca cgctgtaggt atctcagttc      240

ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg      300

ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc      360

actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga      420

gttcttgaag tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc      480

tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac      540

caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg      600

atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc      660

acgttaaggg attttggtca tgaacgcatc tacgactgtg ggtcccgtgg agaaatgtat      720

gaaaccctgt atggagagtg attagcttgc ctcgtccccg ccgggtcacc cggccagcga      780

catggaggcc cagaataccc tccttgacag tcttgacgtg cgcagctcag gggcatgatg      840

tgactgtcgc ccgtacattt agcccataca tccccatgta taatcatttg catccataca      900

ttttgatggc cgcacggcgc gaagcaaaaa ttacggctcc tcgctgcaga cctgcgagca      960

gggaaacgct cccctcacag acgcgttgaa ttgtccccac gccgcgcccc tgtagagaaa     1020

tataaaaggt taggatttgc cactgaggtt cttctttcat atacttcctt ttaaaatctt     1080

gctaggatac agttctcaca tcacatccga acataaacaa ccatgggtaa ggaaaagact     1140

cacgtttcga ggccgcgatt aaattccaac atggatgctg atttatatgg gtataaatgg     1200

gctcgcgata atgtcgggca atcaggtgcg acaatctatc gattgtatgg gaagcccgat     1260

gcgccagagt tgtttctgaa acatggcaaa ggtagcgttg ccaatgatgt tacagatgag     1320

atggtcagac taaactggct gacggaattt atgcctcttc cgaccatcaa gcattttatc     1380

cgtactcctg atgatgcatg gttactcacc actgcgatcc ccggcaaaac agcattccag     1440

gtattagaag aatatcctga ttcaggtgaa aatattgttg atgcgctggc agtgttcctg     1500

cgccggttgc attcgattcc tgtttgtaat tgtcctttta acagcgatcg cgtatttcgt     1560

ctcgctcagg cgcaatcacg aatgaataac ggtttggttg atgcgagtga ttttgatgac     1620

gagcgtaatg gctggcctgt tgaacaagtc tggaaagaaa tgcataagct tttgccattc     1680

tcaccggatt cagtcgtcac tcatggtgat ttctcacttg ataaccttat ttttgacgag     1740

gggaaattaa taggttgtat tgatgttgga cgagtcggaa tcgcagaccg ataccaggat     1800

cttgccatcc tatggaactg cctcggtgag ttttctcctt cattacagaa acggcttttt     1860

caaaaatatg gtattgataa tcctgatatg aataaattgc agtttcattt gatgctcgat     1920

gagtttttct aatcagtact gacaataaaa agattcttgt tttcaagaac ttgtcatttg     1980

tatagttttt ttatattgta gttgttctat tttaatcaaa tgttagcgtg atttatattt     2040

tttttcgcct cgacatcatc tgcccagatg cgaagttaag tgcgcagaaa gtaatatcat     2100

gcgtcaatcg tatgtgaatg ctggtcgcta tactgctgtc gattcgatac taacgccgcc     2160

atccagtgtc gaaaacgagc tctcgagaac ccttaatcat acgttgaaac tacggcaaag     2220

gattggtcag atcgcttcat acaggggtat cccggcataa ccctcactaa agggaacaaa     2280

agctggagct cgtttaaaag caacaggcgc gttggacttt taattttcga ggaccgcgaa     2340

tccttacatc acacccaatc ccccacaagt gatcccccac acaccatagc ttcaaaatgt     2400

ttctactcct tttttactct tccagatttt ctcggactcc gcgcatcgcc gtaccacttc     2460

aaaacaccca agcacagcat actaaatttc ccctctttct tcctctaggg tgtcgttaat     2520

tacccgtact aaaggtttgg aaaagaaaaa agagaccgcc tcgtttcttt ttcttcgtcg     2580

aaaaaggcaa taaaaatttt tatcacgttt ctttttcttg aaaatttttt tttttgattt     2640

ttttctcttt cgatgacctc ccattgatat ttaagttaat aaacggtctt caatttctca     2700

agtttcagtt tcatttttct tgttctatta caactttttt tacttcttgc tcattagaaa     2760

gaaagcatag caatctaatc taagttttaa tggcgggggt cggaatgatt aaagaaaggg     2820

gctgtgggcg agattgaaac aatggcttca gaaaaagaaa ttaggagaga gagattcttg     2880

aacgttttcc ctaaattagt agaggaattg aacgcatcgc ttttggctta cggtatgcct     2940

aaggaagcat gtgactggta tgcccactca ttgaactaca acactccagg cggtaagcta     3000

aatagaggtt tgtccgttgt ggacacgtat gctattctct ccaacaagac cgttgaacaa     3060

ttggggcaag aagaatacga aaaggttgcc attctaggtt ggtgcattga gttgttgcag     3120

gcttacttct tggtcgccga tgatatgatg gacaagtcca ttaccagaag aggccaacca     3180

tgttggtaca aggttcctga agttggggaa attgccatca atgacgcatt catgttagag     3240

gctgctatct acaagctttt gaaatctcac ttcagaaacg aaaaatacta catagatatc     3300

accgaattgt tccatgaggt caccttccaa accgaattgg gccaattgat ggacttaatc     3360

actgcacctg aagacaaagt cgacttgagt aagttctccc taaagaagca ctccttcata     3420

gttactttcg agactgctta ctattctttc tacttgcctg tcgcattggc catgtacgtt     3480

gccggtatca cggatgaaaa ggatttgaaa caagccagag atgtcttgat tccattgggt     3540

gaatacttcc aaattcaaga tgactactta gactgcttcg gtaccccaga acagatcggt     3600

aagatcggta cagatatcca agataacaaa tgttcttggg taatcaacaa ggcattggaa     3660

cttgcttccg cagaacaaag aaagacttta gacgaaaatt acggtaagaa ggactcagtc     3720

gcagaagcca aatgcaaaaa gattttcaat gacttgaaaa ttgaacagct ataccacgaa     3780

tatgaagagt ctattgccaa ggatttgaag gccaaaattt ctcaggtcga tgagtctcgt     3840

ggcttcaaag ctgatgtctt aactgcgttc ttgaacaaag tttacaagag aagcaaataa     3900

ccagttaata aaccgtggca aacatgatgg tggcctaatg gaggtcacca acagaagacg     3960

ggagacacta gcacacaact ttaccaggca aggtatttga cgctagcatg tgtccaattc     4020

agtgtcattt atgatttttt gtagtaggat ataaatatat acagcgctcc aaatagtgcg     4080

gttgccccaa aaacaccacg gaacctcatc tgttctcgta ctttgttgtg acaaagtagc     4140

tcactgcctt attatcacat tttcattatg caacgcttcg gaaaatacga tgttgaaaat     4200

gcctctagag atgaaaaaca atcgtaaaag ggtcctgcgt aattgaaaca tttgatcagt     4260

atgcagtggc acagaaacaa ccaggaatac tatagtcata ggcaatacaa ggtatatatt     4320

ggctatgcag acccctccag aaagtaccga cgtcaagtta gatacactta acgaacctag     4380

tgcacattta attgagaaaa atgtggctct tcctaaggac atattccgtt cgtacttgag     4440

ttattggatc tatgaaatcg ctcgctatac accagtcatg attttgtcgc ggccgcggta     4500

cctaataact tcgtatagca tacattatac gaagttat                             4538


<210>  151
<211>  3503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Erg1p:UB14-Erg20:deg

<400>  151
tgtgcacaaa ggccataata ttatgtctac agaatatact agatgtcctc cctataggat       60

atagtaatcc tctaaatgga accgatattt ctacataata atattacgat tattcctcct      120

tccgttttat atgtttcatt atcctagcac actatcaatc tttgcatttc agcttccatt      180

agatttgatg actatttctc aatctttatg ttatctcctt acgccgcatg tgataatata      240

ctgctagtat gactactagt tgatagaaga tagttgattt ttactccaac aaaagtaaca      300

atattattta gaactataga ttccattttg tgcattccca tattctcgag gaaaactttt      360

agtatattct gtagacataa tattatcgcc tttgtgaaca atagaatccc aacaattgtc      420

gcaaatttac caattttcta gattgcagtc accttttcaa ttaatcacta gtgtttcact      480

tgtaacattg tcgttgttgt ttaacgtatt ctgtcccgtg ccaactatga caaaaatgca      540

atgatttcag cggttaaata cgaagcgcaa caagagttag cgaaaaataa gtaccaccat      600

tctacgctac cattacttac tgaaattaga gacaactgtt atctattggc agatgttcat      660

acggggcttt caaatattga tgaaattatg tgatgtttag aagaagattc gaactgtttt      720

cagtagattt ggtaactgtg caaccataac tcatgcctac gttcgggatt taatcttctc      780

gcagtctgca ggcgccttga gatttgcgtt cggcctaaac gtttgctcca caaacgtgaa      840

tggtatgaac atggacatga gcgtggttca gggcactcta cgggatcgtg gcgaatggga      900

atcgttctgc aagctcttct accaaaccat cggcgaattt gcgtcgcttt aatgcgatac      960

tgccgtagcg ggccttcgta tagctcggcc gagctcgtac aaaaggcaag cagtgtatcg     1020

gacagagctg atataacaca atacgctcgt agtcgatgca tgccgtggct gctctcggtc     1080

gggtataagt cttagacaat agtcttacct cgcatgtata ataaatcttt tgtatttaat     1140

ctattatatg tttctatgct tttttttcct attgttgttt gcttttcctt ttccttattt     1200

ctttctagct tctaattttc tttctttttt tttttttttt cattgaaaat tatatatata     1260

tatatatatc agaacaattg tccagtattg aacaatacag gttatttcga acaattgaaa     1320

aaaaaaaatc acagaaaaac atatcgagaa aagggtcaaa acaatgcaga ttttcgtcaa     1380

gactttgacc ggtaaaacca taacattgga agttgaatct tccgatacca tcgacaacgt     1440

taagtcgaaa attcaagaca aggaaggtat ccctccagat caacaaagat tgatctttgc     1500

cggtaagcag ctagaagacg gtagaacgct gtctgattac aacattcaga aggagtccac     1560

cttacatctt gtgctaaggc taagaggtgg tttccacaaa tctggtgctt ggttgttgcc     1620

agtttctttg gttaagggtt ctggtgcttc agaaaaagaa attaggagag agagattctt     1680

gaacgttttc cctaaattag tagaggaatt gaacgcatcg cttttggctt acggtatgcc     1740

taaggaagca tgtgactggt atgcccactc attgaactac aacactccag gcggtaagct     1800

aaatagaggt ttgtccgttg tggacacgta tgctattctc tccaacaaga ccgttgaaca     1860

attggggcaa gaagaatacg aaaaggttgc cattctaggt tggtgcattg agttgttgca     1920

ggcttacttc ttggtcgccg atgatatgat ggacaagtcc attaccagaa gaggccaacc     1980

atgttggtac aaggttcctg aagttgggga aattgccatc aatgacgcat tcatgttaga     2040

ggctgctatc tacaagcttt tgaaatctca cttcagaaac gaaaaatact acatagatat     2100

caccgaattg ttccatgagg tcaccttcca aaccgaattg ggccaattga tggacttaat     2160

cactgcacct gaagacaaag tcgacttgag taagttctcc ctaaagaagc actccttcat     2220

agttactttc aagactgctt actattcttt ctacttgcct gtcgcattgg ccatgtacgt     2280

tgccggtatc acggatgaaa aggatttgaa acaagccaga gatgtcttga ttccattggg     2340

tgaatacttc caaattcaag atgactactt agactgcttc ggtaccccag aacagatcgg     2400

taagatcggt acagatatcc aagataacaa atgttcttgg gtaatcaaca aggcattgga     2460

acttgcttcc gcagaacaaa gaaagacttt agacgaaaat tacggtaaga aggactcagt     2520

cgcagaagcc aaatgcaaaa agattttcaa tgacttgaaa attgaacagc tataccacga     2580

atatgaagag tctattgcca aggatttgaa ggccaaaatt tctcaggtcg atgagtctcg     2640

tggcttcaaa gctgatgtct taactgcgtt cttgaacaaa gtttacaaga gaagcaaata     2700

gtggacttct tcgccagagg tttggtcaag tctccaatca aggttgtcgg cttgtctacc     2760

ttgccagaaa tttacgaaaa gatggaaaag ggtcaaatcg ttggtagata cgttgttgac     2820

acttctaaat aagcgaattt cttatgattt atgattttta ttattaaata agttataaaa     2880

aaaataagtg tatacaaatt ttaaagtgac tcttaggttt taaaacgaaa attcttattc     2940

ttgagtaact ctttcctgta ggtcaggttg ctttctcagg tatagcatga ggtcgctctt     3000

attgaccaca cctctaccgg catggaatcg tccccaacaa aagtgggctc tcaaaattca     3060

tcacatttaa atgcatatag gaagagcaac agttggtttg catctgatgt tccttaaaga     3120

tttcgacata atgtgcgaag tagataaaat gggtcattta ttaatagtta tttcattatt     3180

aaccagttgt ggtacaaatg caactaaaga aaaaaactac taaactatcc gggaaatgcg     3240

ccttagattg cacttcttaa ttcttatttt cgatttttat ttttcctttg ataatcataa     3300

agagaaacga cgatcatttc taaagccatt tctgctagta taccgttaaa taagaaaaat     3360

aaagccaaat attataattt ttctaatgtg aatccataaa tatcaaagca tgcaaaaagg     3420

gaaagaagta atgtcttgga tttatatagc gtatttgtct aaggggagcc agctttggcg     3480

cgcctatcga gagaccgatt aca                                             3503


<210>  152
<211>  4859
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tHMGr-IDI

<400>  152
ggcgcgcccg agatctttgt gttcggttac ccggctcaga tcctaacttc gtatgtttat       60

tcgtataagt tactgttgtc cacaggcaat actctgcaga aaattaaaac ggcattaatg      120

ctaggacaac cagaattgtt actactgtat gtgcgatagt tgataactgc aacattatgc      180

ccggtatatt ctcaaaaaac cctattactg catacgaaga aatcgctcga gtttatcatt      240

atcaatactg ccatttcaaa gaatacgtaa ataattaata gtagtgattt tcctaacttt      300

atttagtcaa aaaattagcc ttttaattct gctgtaaccc gtacatgccc aaaatagggg      360

gcgggttaca cagaatatat aacatcgtag gtgtctgggt gaacagttta ttcctggcat      420

ccactaaata taatggagcc cgctttttaa gctggcatcc agaaaaaaaa agaatcccag      480

caccaaaata ttgttttctt caccaaccat cagttcatag gtccattctc ttagcgcaac      540

tacagagaac aggggcacaa acaggcaaaa aacgggcaca acctcaatgg agtgatgcaa      600

cctgcctgga gtaaatgatg acacaaggca attgacccac gcatgtatct atctcatttt      660

cttacacctt ctattacctt ctgctctctc tgatttggaa aaagctgaaa aaaaaggttg      720

aaaccagttc cctgaaatta ttcccctact tgactaataa gtatataaag acggtaggta      780

ttgattgtaa ttctgtaaat ctatttctta aacttcttaa attctacttt tatagttagt      840

ctttttttta gttttaaaac accaagaact tagtttcgaa aacaatggtt ttaaccaata      900

aaacagtcat ttctggatcg aaagtcaaaa gtttatcatc tgcgcaatcg agctcatcag      960

gaccttcatc atctagtgag gaagatgatt cccgcgatat tgaaagcttg gataagaaaa     1020

tacgtccttt agaagaatta gaagcattat taagtagtgg aaatacaaaa caattgaaga     1080

acaaagaggt cgctgccttg gttattcacg gtaagttacc tttgtacgct ttggagaaaa     1140

aattaggtga tactacgaga gcggttgcgg tacgtaggaa ggctctttca attttggcag     1200

aagctcctgt attagcatct gatcgtttac catataaaaa ttatgactac gaccgcgtat     1260

ttggcgcttg ttgtgaaaat gttataggtt acatgccttt gcccgttggt gttataggcc     1320

ccttggttat cgatggtaca tcttatcata taccaatggc aactacagag ggttgtttgg     1380

tagcttctgc catgcgtggc tgtaaggcaa tcaatgctgg cggtggtgca acaactgttt     1440

taactaagga tggtatgaca agaggcccag tagtccgttt cccaactttg aaaagatctg     1500

gtgcctgtaa gatatggtta gactcagaag agggacaaaa cgcaattaaa aaagctttta     1560

actctacatc aagatttgca cgtctgcaac atattcaaac ttgtctagca ggagatttac     1620

tcttcatgag atttagaaca actactggtg acgcaatggg tatgaatatg atttctaaag     1680

gtgtcgaata ctcattaaag caaatggtag aagagtatgg ctgggaagat atggaggttg     1740

tctccgtttc tggtaactac tgtaccgaca aaaaaccagc tgccatcaac tggatcgaag     1800

gtcgtggtaa gagtgtcgtc gcagaagcta ctattcctgg tgatgttgtc agaaaagtgt     1860

taaaaagtga tgtttccgca ttggttgagt tgaacattgc taagaatttg gttggatctg     1920

caatggctgg gtctgttggt ggatttaacg cacatgcagc taatttagtg acagctgttt     1980

tcttggcatt aggacaagat cctgcacaaa atgttgaaag ttccaactgt ataacattga     2040

tgaaagaagt ggacggtgat ttgagaattt ccgtatccat gccatccatc gaagtaggta     2100

ccatcggtgg tggtactgtt ctagaaccac aaggtgccat gttggactta ttaggtgtaa     2160

gaggcccgca tgctaccgct cctggtacca acgcacgtca attagcaaga atagttgcct     2220

gtgccgtctt ggcaggtgaa ttatccttat gtgctgccct agcagccggc catttggttc     2280

aaagtcatat gacccacaac aggaaacctg ctgaaccaac aaaacctaac aatttggacg     2340

ccactgatat aaatcgtttg aaagatgggt ccgtcacctg cattaaatcc taatggactt     2400

cttcgccaga ggtttggtca agtctccaat caaggttgtc ggcttgtcta ccttgccaga     2460

aatttacgaa aagatggaaa agggtcaaat cgttggtaga tacgttgttg acacttctaa     2520

ataagcgaat ttcttatgat ttatgatttt tattattaaa taagttataa aaaaaataag     2580

tgtatacaaa ttttaaagtg actcttaggt tttaaaacga aaattcttat tcttgagtaa     2640

ctctttcctg taggtcaggt tgctttctca ggtatagcat gaggtcgctc ttattgacca     2700

cacctctacc ggcatgcaag caacaggcgc gttggacttt taattttcga ggaccgcgaa     2760

tccttacatc acacccaatc ccccacaagt gatcccccac acaccatagc ttcaaaatgt     2820

ttctactcct tttttactct tccagatttt ctcggactcc gcgcatcgcc gtaccacttc     2880

aaaacaccca agcacagcat actaaatttc ccctctttct tcctctaggg tgtcgttaat     2940

tacccgtact aaaggtttgg aaaagaaaaa agagaccgcc tcgtttcttt ttcttcgtcg     3000

aaaaaggcaa taaaaatttt tatcacgttt ctttttcttg aaaatttttt tttttgattt     3060

ttttctcttt cgatgacctc ccattgatat ttaagttaat aaacggtctt caatttctca     3120

agtttcagtt tcatttttct tgttctatta caactttttt tacttcttgc tcattagaaa     3180

gaaagcatag caatctaatc taagttttaa taaacaatga ctgccgacaa caatagtatg     3240

ccccatggtg cagtatctag ttacgccaaa ttagtgcaaa accaaacacc tgaagacatt     3300

ttggaagagt ttcctgaaat tattccatta caacaaagac ctaatacccg atctagtgag     3360

acgtcaaatg acgaaagcgg agaaacatgt ttttctggtc atgatgagga gcaaattaag     3420

ttaatgaatg aaaattgtat tgttttggat tgggacgata atgctattgg tgccggtacc     3480

aagaaagttt gtcatttaat ggaaaatatt gaaaagggtt tactacatcg tgcattctcc     3540

gtctttattt tcaatgaaca aggtgaatta cttttacaac aaagagccac tgaaaaaata     3600

actttccctg atctttggac taacacatgc tgctctcatc cactatgtat tgatgacgaa     3660

ttaggtttga agggtaagct agacgataag attaagggcg ctattactgc ggcggtgaga     3720

aaactagatc atgaattagg tattccagaa gatgaaacta agacaagggg taagtttcac     3780

tttttaaaca gaatccatta catggcacca agcaatgaac catggggtga acatgaaatt     3840

gattacatcc tattttataa gatcaacgct aaagaaaact tgactgtcaa cccaaacgtc     3900

aatgaagtta gagacttcaa atgggtttca ccaaatgatt tgaaaactat gtttgctgac     3960

ccaagttaca agtttacgcc ttggtttaag attatttgcg agaattactt attcaactgg     4020

tgggagcaat tagatgacct ttctgaagtg gaaaatgaca ggcaaattca tagaatgcta     4080

taaacagaag acgggagaca ctagcacaca actttaccag gcaaggtatt tgacgctagc     4140

atgtgtccaa ttcagtgtca tttatgattt tttgtagtag gatataaata tatacagcgc     4200

tccaaatagt gcggttgccc caaaaacacc acggaacctc atctgttctc gtactttgtt     4260

gtgacaaagt agctcactgc cttattatca cattttcatt atgcaacgct tcggaaaata     4320

cgatgttgaa aatgcctcta gagatgaaaa acaatcgtaa aagggtcctg cgtaattgaa     4380

acatttgatc agtatgcagt ggcacagaaa caaccaggaa tactatagtc ataggcaata     4440

caaggtatat attggctatg cagacccctc cagaaagtac cgacgtcaag ttagatacac     4500

ttaacgaacc tagtgcacat ttaattgaga aaaatgtggc tcttcctaag gacatattcc     4560

gttcgtactt gagttattgg atctatgaaa tcgctcgcta tacaccagtc atgattttgt     4620

cacactcgta tatgcatgtt gttgaaactc tgttacgctg aactaacaat cacacatgta     4680

gaggtcaccg ggaaaagttg cgaccccatg gaaggtcgat ctcttcgttt ggctttgctt     4740

ggctggcggc attgcgcttc ttcgcttata cccgtctctt gacgctcgag ctcgttcatt     4800

gagatacctt tattcttgca cattttctgg cttttttcgc tactcgggta cggcgcgcc      4859


<210>  153
<211>  7673
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PGK1p:ACC1S659A,S1157A

<400>  153
caagtcgcag tcgaaattca accgctcatt gccactctct ctactgcttg gtgaactagg       60

ctatacgctc aatcagcgcc aagatatata agaagaacag cactcccagt cgtattctgg      120

cacagtatag cctagcacaa tcactgtcac aattgttatc ggttctacaa ttgttctgct      180

ctcttcaatt ttcctttcct tattctactc tttttatccc tacgcacaga tattataaca      240

tctgcataat aggcatttgc aagaattact cgtgagtaag gaaagagtga ggaactatcg      300

catacctgca tttaaagatg ccgatttggg cgcgaatcct ttattttggc ttcaccctca      360

tactattatc agggccagaa aaaggaagtg tttccctcct tcttgaattg atgttaccct      420

cataaagcac gtggcctctt atcgagaaag aaattaccgt cgctcgtgat ttgtttgcaa      480

aaagaacaaa actgaaaaaa cccagacacg ctcgacttcc tgtcttccta ttgattgcag      540

cttccaattt cgtcacacaa caaggtccta gcgacggctc acaggttttg taacaagcaa      600

tcgaaggttc tggaatggcg ggaaagggtt tagtaccaca tgctatgatg cccactgtga      660

tctccagagc aaagttcgtt cgatcgtact gttactctct ctctttcaaa cagaattgtc      720

cgaatcgtgt gacaacaaca gcctgttctc acacactctt ttcttctaac caagggggtg      780

gtttagttta gtagaacctc gtgaaactta catttacata tatataaact tgcataaatt      840

ggtcaatgca agaaatacat atttggtctt ttctaattcg tagtttttca agttcttaga      900

tgctttcttt ttctcttttt tacagatcat caaggaagta attatctact ttttacaaca      960

aatataaaac aatgagcgaa gaaagcttat tcgagtcttc tccacagaag atggagtacg     1020

aaattacaaa ctactcagaa agacatacag aacttccagg tcatttcatt ggcctcaata     1080

cagtagataa actagaggag tccccgttaa gggactttgt taagagtcac ggtggtcaca     1140

cggtcatatc caagatcctg atagcaaata atggtattgc cgccgtgaaa gaaattagat     1200

ccgtcagaaa atgggcatac gagacgttcg gcgatgacag aaccgtccaa ttcgtcgcca     1260

tggccacccc agaagatctg gaggccaacg cagaatatat ccgtatggcc gatcaataca     1320

ttgaagtgcc aggtggtact aataataaca actacgctaa cgtagacttg atcgtagaca     1380

tcgccgaaag agcagacgta gacgccgtat gggctggctg gggtcacgcc tccgagaatc     1440

cactattgcc tgaaaaattg tcccagtcta agaggaaagt catctttatt gggcctccag     1500

gtaacgccat gaggtcttta ggtgataaaa tctcctctac cattgtcgct caaagtgcta     1560

aagtcccatg tattccatgg tctggtaccg gtgttgacac cgttcacgtg gacgagaaaa     1620

ccggtctggt ctctgtcgac gatgacatct atcaaaaggg ttgttgtacc tctcctgaag     1680

atggtttaca aaaggccaag cgtattggtt ttcctgtcat gattaaggca tccgaaggtg     1740

gtggtggtaa aggtatcaga caagttgaac gtgaagaaga tttcatcgct ttataccacc     1800

aggcagccaa cgaaattcca ggctccccca ttttcatcat gaagttggcc ggtagagcgc     1860

gtcacttgga agttcaactg ctagcagatc agtacggtac aaatatttcc ttgttcggta     1920

gagactgttc cgttcagaga cgtcatcaaa aaattatcga agaagcacca gttacaattg     1980

ccaaggctga aacatttcac gagatggaaa aggctgccgt cagactgggg aaactagtcg     2040

gttatgtctc tgccggtacc gtggagtatc tatattctca tgatgatgga aaattctact     2100

ttttagaatt gaacccaaga ttacaagtcg agcatccaac aacggaaatg gtctccggtg     2160

ttaacttacc tgcagctcaa ttacaaatcg ctatgggtat ccctatgcat agaataagtg     2220

acattagaac tttatatggt atgaatcctc attctgcctc agaaatcgat ttcgaattca     2280

aaactcaaga tgccaccaag aaacaaagaa gacctattcc aaagggtcat tgtaccgctt     2340

gtcgtatcac atcagaagat ccaaacgatg gattcaagcc atcgggtggt actttgcatg     2400

aactaaactt ccgttcttcc tctaatgttt ggggttactt ctccgtgggt aacaatggta     2460

atattcactc cttttcggac tctcagttcg gccatatttt tgcttttggt gaaaatagac     2520

aagcttccag gaaacacatg gttgttgccc tgaaggaatt gtccattagg ggtgatttca     2580

gaactactgt ggaatacttg atcaaacttt tggaaactga agatttcgag gataacacta     2640

ttaccaccgg ttggttggac gatttgatta ctcataaaat gaccgctgaa aagcctgatc     2700

caactcttgc cgtcatttgc ggtgccgcta caaaggcttt cttagcatct gaagaagccc     2760

gccacaagta tatcgaatcc ttacaaaagg gacaagttct atctaaagac ctactgcaaa     2820

ctatgttccc tgtagatttt atccatgagg gtaaaagata caagttcacc gtagctaaat     2880

ccggtaatga ccgttacaca ttatttatca atggttctaa atgtgatatc atactgcgtc     2940

aactatctga tggtggtctt ttgattgcca taggcggtaa atcgcatacc atctattgga     3000

aagaagaagt tgctgctaca agattatccg ttgactctat gactactttg ttggaagttg     3060

aaaacgatcc aacccagttg cgtactccat cccctggtaa attggttaaa ttcttggtgg     3120

aaaatggtga acacattatc aagggccaac catatgcaga aattgaagtt atgaaaatgc     3180

aaatgccttt ggtttctcaa gaaaatggta tcgtccagtt attaaagcaa cctggttcta     3240

ccattgttgc aggtgatatc atggctatta tgactcttga cgatccatcc aaggtcaagc     3300

acgctctacc atttgaaggt atgctgccag attttggttc tccagttatc gaaggaacca     3360

aacctgccta taaattcaag tcattagtgt ctactttgga aaacattttg aagggttatg     3420

acaaccaagt tattatgaac gcttccttgc aacaattgat agaggttttg agaaatccaa     3480

aactgcctta ctcagaatgg aaactacaca tctctgcttt acattcaaga ttgcctgcta     3540

agctagatga acaaatggaa gagttagttg cacgttcttt gagacgtggt gctgttttcc     3600

cagctagaca attaagtaaa ttgattgata tggccgtgaa gaatcctgaa tacaaccccg     3660

acaaattgct gggcgccgtc gtggaaccat tggcggatat tgctcataag tactctaacg     3720

ggttagaagc ccatgaacat tctatatttg tccatttctt ggaagaatat tacgaagttg     3780

aaaagttatt caatggtcca aatgttcgtg aggaaaatat cattctgaaa ttgcgtgatg     3840

aaaaccctaa agatctagat aaagttgcgc taactgtttt gtctcattcg aaagtttcag     3900

cgaagaataa cctgatccta gctatcttga aacattatca accattgtgc aagttatctt     3960

ctaaagtttc tgccattttc tctactcctc tacaacatat tgttgaacta gaatctaagg     4020

ctaccgctaa ggtcgctcta caagcaagag aaattttgat tcaaggcgct ttaccttcgg     4080

tcaaggaaag aactgaacaa attgaacata tcttaaaatc ctctgttgtg aaggttgcct     4140

atggctcatc caatccaaag cgctctgaac cagatttgaa tatcttgaag gacttgatcg     4200

attctaatta cgttgtgttc gatgttttac ttcaattcct aacccatcaa gacccagttg     4260

tgactgctgc agctgctcaa gtctatattc gtcgtgctta tcgtgcttac accataggag     4320

atattagagt tcacgaaggt gtcacagttc caattgttga atggaaattc caactacctt     4380

cagctgcgtt ctccaccttt ccaactgtta aatctaaaat gggtatgaac agggctgttt     4440

ctgtttcaga tttgtcatat gttgcaaaca gtcagtcatc tccgttaaga gaaggtattt     4500

tgatggctgt ggatcattta gatgatgttg atgaaatttt gtcacaaagt ttggaagtta     4560

ttcctcgtca ccaatcttct tctaacggac ctgctcctga tcgttctggt agctccgcat     4620

cgttgagtaa tgttgctaat gtttgtgttg cttctacaga aggtttcgaa tctgaagagg     4680

aaattttggt aaggttgaga gaaattttgg atttgaataa gcaggaatta atcaatgctt     4740

ctatccgtcg tatcacattt atgttcggtt ttaaagatgg gtcttatcca aagtattata     4800

cttttaacgg tccaaattat aacgaaaatg aaacaattcg tcacattgag ccggctttgg     4860

ccttccaact ggaattagga agattgtcca acttcaacat taaaccaatt ttcactgata     4920

atagaaacat ccatgtctac gaagctgtta gtaagacttc tccattggat aagagattct     4980

ttacaagagg tattattaga acgggtcata tccgtgatga catttctatt caagaatatc     5040

tgacttctga agctaacaga ttgatgagtg atatattgga taatttagaa gtcaccgaca     5100

cttcaaattc tgatttgaat catatcttca tcaacttcat tgcggtgttt gatatctctc     5160

cagaagatgt cgaagccgcc ttcggtggtt tcttagaaag atttggtaag agattgttga     5220

gattgcgtgt ttcttctgcc gaaattagaa tcatcatcaa agatcctcaa acaggtgccc     5280

cagtaccatt gcgtgccttg atcaataacg tttctggtta tgttatcaaa acagaaatgt     5340

acaccgaagt caagaacgca aaaggtgaat gggtatttaa gtctttgggt aaacctggat     5400

ccatgcattt aagacctatt gctactcctt accctgttaa ggaatggttg caaccaaaac     5460

gttataaggc acacttgatg ggtaccacat atgtctatga cttcccagaa ttattccgcc     5520

aagcatcgtc atcccaatgg aaaaatttct ctgcagatgt taagttaaca gatgatttct     5580

ttatttccaa cgagttgatt gaagatgaaa acggcgaatt aactgaggtg gaaagagaac     5640

ctggtgccaa cgctattggt atggttgcct ttaagattac tgtaaagact cctgaatatc     5700

caagaggccg tcaatttgtt gttgttgcta acgatatcac attcaagatc ggttcctttg     5760

gtccacaaga agacgaattc ttcaataagg ttactgaata tgctagaaag cgtggtatcc     5820

caagaattta cttggctgca aactcaggtg ccagaattgg tatggctgaa gagattgttc     5880

cactatttca agttgcatgg aatgatgctg ccaatccgga caagggcttc caatacttat     5940

acttaacaag tgaaggtatg gaaactttaa agaaatttga caaagaaaat tctgttctca     6000

ctgaacgtac tgttataaac ggtgaagaaa gatttgtcat caagacaatt attggttctg     6060

aagatgggtt aggtgtcgaa tgtctacgtg gatctggttt aattgctggt gcaacgtcaa     6120

gggcttacca cgatatcttc actatcacct tagtcacttg tagatccgtc ggtatcggtg     6180

cttatttggt tcgtttgggt caaagagcta ttcaggtcga aggccagcca attattttaa     6240

ctggtgctcc tgcaatcaac aaaatgctgg gtagagaagt ttatacttct aacttacaat     6300

tgggtggtac tcaaatcatg tataacaacg gtgtttcaca tttgactgct gttgacgatt     6360

tagctggtgt agagaagatt gttgaatgga tgtcttatgt tccagccaag cgtaatatgc     6420

cagttcctat cttggaaact aaagacacat gggatagacc agttgatttc actccaacta     6480

atgatgaaac ttacgatgta agatggatga ttgaaggtcg tgagactgaa agtggatttg     6540

aatatggttt gtttgataaa gggtctttct ttgaaacttt gtcaggatgg gccaaaggtg     6600

ttgtcgttgg tagagcccgt cttggtggta ttccactggg tgttattggt gttgaaacaa     6660

gaactgtcga gaacttgatt cctgctgatc cagctaatcc aaatagtgct gaaacattaa     6720

ttcaagaacc tggtcaagtt tggcatccaa actccgcctt caagactgct caagctatca     6780

atgactttaa caacggtgaa caattgccaa tgatgatttt ggccaactgg agaggtttct     6840

ctggtggtca acgtgatatg ttcaacgaag tcttgaagta tggttcgttt attgttgacg     6900

cattggtgga ttacaaacaa ccaattatta tctatatccc acctaccggt gaactaagag     6960

gtggttcatg ggttgttgtc gatccaacta tcaacgctga ccaaatggaa atgtatgccg     7020

acgtcaacgc tagagctggt gttttggaac cacaaggtat ggttggtatc aagttccgta     7080

gagaaaaatt gctggacacc atgaacagat tggatgacaa gtacagagaa ttgagatctc     7140

aattatccaa caagagtttg gctccagaag tacatcagca aatatccaag caattagctg     7200

atcgtgagag agaactattg ccaatttacg gacaaatcag tcttcaattt gctgatttgc     7260

acgataggtc ttcacgtatg gtggccaagg gtgttatttc taaggaactg gaatggaccg     7320

aggcacgtcg tttcttcttc tggagattga gaagaagatt gaacgaagaa tatttgatta     7380

aaaggttgag ccatcaggta ggcgaagcat caagattaga aaagatcgca agaattagat     7440

cgtggtaccc tgcttcagtg gaccatgaag atgataggca agtcgcaaca tggattgaag     7500

aaaactacaa aactttggac gataaactaa agggtttgaa attagagtca ttcgctcaag     7560

acttagctaa aaagatcaga agcgaccatg acaatgctat tgatggatta tctgaagtta     7620

tcaagatgtt atctaccgat gataaagaaa aattgttgaa gactttgaaa taa            7673


<210>  154
<211>  2177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OAC

<400>  154
ttagtagatg atagttgatt tttattccaa cattattgta ctcagcaatt gttgcgaaac       60

agacaagatt aagtatatta ttcaaggcct tgcttaccta gatgaaccat tgagaaatat      120

acatattgag caatacctct aggtccgaag ttccgtgcct acacccttta gtcagattta      180

gattatatga gataagtggt attttgtgga ccaagtttgt gattaatctg atatcaagtt      240

actttcttaa cgacattagg acgccagggt agccagtatt attcaagtcc atagaacagc      300

ctgtatacct tcacttcatt aggtatattc ttggttatgc gttatttaaa tcctcatctg      360

ccgctgctta aaaaaagcag ctaaagtgtt gcgtaggcac ggattagaag ccgccgagcg      420

ggtgacagcc ctccgaagga agactctcct ccgtgcgtcc tcgtcttcac cggtcgcgtt      480

cctgaaacgc agatgtgcct cgcgccgcac tgctccgaac aataaagatt ctacaatact      540

agcttttatg gttatgaaga ggaaaaattg gcagtaacct ggccccacaa accttcaaat      600

gaacgaatca aattaacaac cataggatga taatgcgatt agttttttag ccttatttct      660

ggggtaatta atcagcgaag cgatgatttt tgatctatta acagatatat aaatgcaaaa      720

actgcataac cactttaact aatactttca acattttcgg tttgtattac ttcttattca      780

aatgtaataa aagtatcaac aaaaaattgt taatatacct ctatacttta acgtcaagga      840

gatggccgtc aagcacttga tcgtcttaaa gtttaaggac gagatcactg aagcccaaaa      900

ggaagaattc ttcaaaactt acgttaactt ggttaacatc attcctgcta tgaaggacgt      960

ctactggggt aaggatgtca ctcaaaaaaa caaggaagaa ggttataccc acatcgttga     1020

agtcaccttc gaatctgttg aaactattca agactacatc attcacccag ctcacgtcgg     1080

tttcggtgat gtttacagat ctttctggga aaaattgttg atcttcgact acaccccaag     1140

aaagggctaa agtgctttta actaagaatt attagtcttt tctgcttatt ttttcatcat     1200

agtttagaac actttatatt aacgaatagt ttatgaatct atttaggttt aaaaattgat     1260

acagttttat aagttacttt ttcaaagact cgtgctgtct attgcataat gcactggaag     1320

gggaaaaaaa aggtgcacac gcgtggcttt ttcttgaatt tgcagtttga aaaataacta     1380

catggatgat aagaaaacat ggagtacagt cactttgaga accttcaatc agctggtaac     1440

gtcttcgtta attggatact caaaaaagat ggatagcatg aatcacaaga tggaaggaaa     1500

tgcgggccac gaccacagtg atatgcatat gggagatgga gatgatacct tccgttaatt     1560

cgggtttcaa tcacttcgtt tgtctatcgt atcgcagcct agtgaatatt taattctttc     1620

aataaaaaag gcttaaaatc accatgaaaa tcacaagagg aatctttcaa caagaacaat     1680

agtatacaat ccatgaatga aggagttcat atttgactag aactatacaa aggttttgta     1740

ctgtttttac tgtgagggta gcatctcatt tatccagaat ctcagaaggg agaaacccaa     1800

tcgctaaatc gatattatca cccagaagtt tcaaataggc gattgtagaa tatacacagg     1860

gacaaccact cagtttatgg cttcagtgcg cgcccagttc tggaggaaag cattatcgaa     1920

gtaataaaac tttaaaaaag ctctccgcaa ctaatgagga ttgcagtatc cagataccct     1980

tgttttctgc caaatgaaca cttttactat gtcatataaa caaaaagtgc catttcttgg     2040

tactgcttca gtcttaggaa tggtcaatac gttattatta cttaaatata cgattaataa     2100

catgctctgt tgcgtattta gtaagtgtgt aaggaaactg taatattacc taaccggtat     2160

cccacgtgtt tcacgaa                                                    2177


<210>  155
<211>  4707
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PT254-R2S

<400>  155
agtatgacaa gttttaatcg agatagtttg acgttcgttt tttactttga atatactcgt       60

agtcttttta ctttttgagt ataaaaaaaa aatgactagc aaaataaaat tagtagtcta      120

aaaaagaaag ctcgcactca ggatcgaact aaggaccaac agatttgcaa tctgctgcgc      180

taccactgcg ccatacgagc ttttgaatta tggtaatttt gattatccta gaatgttata      240

tctcaatatc tcaatatatt ttggacatct atgaaacacc cataaagcag ccgctaccaa      300

acagacaaga ttcagtatgt aaggtaaata cctttttgca cagttaaact acccaaactt      360

attaaagctt gataaattac tgaaattcca cctttcagtt agattcaggc ctcatataga      420

ttagatatag ggtacgtaac attctgtcaa ccaagttgtt ggaatgaaag tctaaaatgt      480

catctattcg gtagcactca tgttactagt atactgtcac atgcggtgta acgtggggac      540

ataaaacaga catcaaatat aatggaagct gaaatgcaaa gatcgataat gtaataggaa      600

tgaaacatat aaaacgaaag gagaagtaat ggtaatatta gtatgtagaa ataccgattc      660

aattttgggg attcttatat tctcgagaga atttctagta taatctgtat acataatatt      720

ataggcttta ccaacaatgg aatttcgaca attatcatat tattcaccaa ttaatcacaa      780

gttggtaatg agtttgataa caagttactt tcttaacaac gttagtatcg tcaaaacact      840

cggttttact cgagcttgta gcacaataat accgtgtaga gttctgtatt gttcttctta      900

gtgcttgtat atgctcatcc cgaccttcca ttatgctggt ctcttcgccc gagaacctca      960

gttacttttc cttatgcgca tagacataca agtggacaga tgatgggtac gggcctctaa     1020

tacatccaac actctacgcc ctcttcaaga gctagaaggg caccctgcag ttggaaaggg     1080

aattatttcg taaggcgagc ccataccgtc attcatgcgg aagagttaac acgattggaa     1140

gtaggaatag tttcgaacca cggttactaa tcctaataac ggaacgctgt ctgaaggatg     1200

agtgtcagcg agtgtaactc gatgagctac ccagtagtcg tactggtcga gacaaccctt     1260

gccaacaggg agttcttcag agacatggag gctcaaaacg aaattattga cagcctagac     1320

atcaatagtc atacaacaga aagcgaccac ccaactttgg ctgataatag cgtataaaca     1380

atgcatactt tgtacgttca aaatacaatg cagtagatat atttatgcat attacatata     1440

atacatatca cataggaagc aacaggcgcg ttggactttt aattttcgag gaccgcgaat     1500

ccttacatca cacccaatcc cccacaagtg atcccccaca caccatagct tcaaaatgtt     1560

tctactcctt ttttactctt ccagattttc tcggactccg cgcatcgccg taccacttca     1620

aaacacccaa gcacagcata ctaaatttcc cctctttctt cctctagggt gtcgttaatt     1680

acccgtacta aaggtttgga aaagaaaaaa gacaccgcct cgtttctttt tcttcgtcga     1740

aaaaggcaat aaaaattttt atcacgtttc tttttcttga aaattttttt ttttgatttt     1800

tttctctttc gatgacctcc cattgatatt taagttaata aacggtcatc aatttctcaa     1860

gtttcagttt catttttctt gttctattac aacttttttt acttcttgct cattagaaag     1920

aaagcatagc aatctaatct aagttttaat tacaaaatga gagccggttc cgatcaaatt     1980

gaaggttctc cacatcatga atccgataac tctattgcca ccaagatttt gaacttcggt     2040

catacttgtt ggaagttgca aagaccatat gttgtcaagg gtatgatttc tattgcttgc     2100

ggtttgtttg gtcgtgagtt gtttaacaac agacacttgt tttcttgggg cttgatgtgg     2160

aaagcttttt ttgctttggt tcccatcctg tcctttaatt tctttgccgc cattatgaac     2220

cagatctacg atgttgatat cgacagaatc aacaagccag atttgccatt ggtttctggt     2280

gaaatgtcta ttgaaaccgc ctggattttg tccattatcg ttgctttgac tggtttgatc     2340

gttaccatca agttgaaatc tgctcccttg ttcgttttca tctacatctt tggtattttc     2400

gctggtttcg cttattccgt tccaccaatt agatggaaac aatacccatt caccaatttc     2460

ttgatcacca tctcttctca tgttggtttg gctttcactt cttactctgc tactacttct     2520

gctttgggtt taccatttgt ttggaggcca gctttctctt tcattattgc tttcatgacc     2580

gttatgggta tgaccattgc tttcgctaag gatatctctg atattgaagg tgatgctaag     2640

tacggtgttt ctactgttgc tacaaaattg ggtgctagaa acatgacctt tgttgtctct     2700

ggtgttctgt tgttgaacta cttggtttcc atttccattg gtatcatttg gccacaggtt     2760

ttcaagtcca acatcatgat tttgtctcat gccatcttgg ctttctgctt gatttttcaa     2820

actagagaat tggccttggc taactatgct tctgctccat ctagacaatt cttcgaattc     2880

atctggttgt tgtactacgc cgaatacttc gtctacgtgt tcattctcga gcatgcatct     2940

agagggccgc atcatgtaat tagttatgtc acgcttacat tcacgccctc cccccacatc     3000

cgctctaacc gaaaaggaag gagttagaca acctgaagtc taggtcccta tttatttttt     3060

tatagttatg ttagtattaa gaacgttatt tatatttcaa atttttcttt tttttctgta     3120

cagacgcgtg tacgcatgta acattatact gaaaaccttg cttgagaagg ttttgggacg     3180

ctcgaaggct ttaatttgcc cagctctaat gcactcaatc ccgaggcctg acgcgacata     3240

tcagcttaga ctagggcggg ggtgttgacg tttggggttg aataaatcta ttgtactaat     3300

cggcttcaac gtgccccacg ggtggcacct caggaggggc ccacagcgag gaagtaaact     3360

gttattcgtc ggcgatggtg gtagctaatt atgttccttg ccactacaat agtatctaag     3420

ccgtgtaatg ggaacatcca cactttagtg aatcgatgtg cagcttcaga ataccattcc     3480

ttgaagccgt gtccataaac aatatcgaga gaccgattac actcgagcat gcatctagag     3540

ggccgcatca tgtaattagt tatgtcacgc ttacattcac gccctccccc cacatccgct     3600

ctaaccgaaa aggaaggagt tagacaacct gaagtctagg tccctattta tttttttata     3660

gttatgttag tattaagaac gttatttata tttcaaattt ttcttttttt tctgtacaga     3720

cgcgtgtacg catgtaacat tatactgaaa accttgcttg agaaggtttt gggacgctcg     3780

aaggctttaa tttgctttgc gaaaccctat gctctgttgt tcggatttga aattttaaaa     3840

ctacattaat gtgttagttt ttctttcttt ctttctttgt cttgacgtga tttggacttc     3900

tgtcttgcat tcgcgtccat tcatctgacc caatattcct tttggttttg ttatccttat     3960

aaaaagaaag gaagcttctt agagggaaaa aaatgatgaa gagtaatgcc aaaatataaa     4020

taaataaata aatatgaaaa tcattttcta tttttaatag aataagaaga gcatcttaag     4080

attacaattt caagaaatag tttacacagt atatccaata actccaataa actactttcc     4140

tatacaaatt tctatggtgg gattaatagt aaaacttctg tacttctcta attcaccaag     4200

aaattaaggt aaacatctgg taagcactat ccagcttttt gctattacac atatggcttt     4260

tctgcaatca tttcttccca ttttgtctca agccgttagt cttgaaacca caggcggagt     4320

agagttactt gatgcggtat tttacatgcc ttttttcact gcaaaaaaaa tgaaatacat     4380

atttacacga tttgcaggac agtttacgat agtgagtatg cagaatagtt aacacctttg     4440

ttttatcctt ttgtgtctta attatatgat ataaaggcgc ctggcgttat cggatagtaa     4500

tagatgctag ttatcaacat ttcacaattg aaggaaataa agttgaagta ctcaacaaaa     4560

acttacttca gaattaaatt tttgggggga acataggcat cctatgacag gtgaccacaa     4620

gcccctcaac gcaatctaat attttacaaa gtggtaaaat tctttcgttc ttcgttttaa     4680

tatacagtca tttattgatt ctattac                                         4707


<210>  156
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OstI-pro-alpha-f(I)

<400>  156

Met Arg Gln Val Trp Phe Ser Trp Ile Val Gly Leu Phe Leu Cys Phe 
1               5                   10                  15      


Phe Asn Val Ser Ser Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu 
            20                  25                  30          


Thr Ala Gln Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu 
        35                  40                  45              


Gly Asp Phe Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn 
    50                  55                  60                  


Gly Leu Leu Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu 
65                  70                  75                  80  


Glu Gly Val Ser Leu Glu Lys Arg Glu Ala Glu Ala 
                85                  90          


<210>  157
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G/A18E/S60T/G351I/A383V/L451G

<400>  157
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca ggggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  158
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/A18E/T49R/V97E/G351I/A383V/L451G

<400>  158
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  159
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/A18E/T49R/V97E/G351I/A383V/L451G

<400>  159
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  160
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/S60T/G351I/A383V/L451G

<400>  160
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca acggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgctac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatac tacccctaag ccattggtta tcgtcacccc aacgcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagtcccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  161
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3G/A18E/S60T/G351I/A383V/L451G

<400>  161

Met Pro Gly Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  162
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/A18E/T49R/V97E/G351I/A383V/L451G

<400>  162

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  163
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3W/A18E/T49R/V97E/G351I/A383V/L451G

<400>  163

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  164
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC154-R3T/S60T/G351I/A383V/L451G

<400>  164

Met Pro Thr Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Ala Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Thr Thr Pro Lys Pro Leu Val Ile Val Thr Pro Thr His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Val Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  165
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-I351G

<400>  165
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatggtgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  166
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-S367R(=CGG)

<400>  166
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aacgggtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  167
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-Q274G

<400>  167
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aacgggggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  168
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-I351M

<400>  168
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatggcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  169
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-V383A

<400>  169
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gcgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  170
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-S367Q

<400>  170
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aacaggtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  171
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-S367N

<400>  171
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aaaacgtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  172
<211>  7266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-S367R(=AGG)

<400>  172
aagagtaaaa aattgtactt ggcggataat gcctttagcg gcttaactgt gccctccatg       60

gaaaaatcag tcaagatatc cacatgtgtt tttagtaaac aaattttggg acctaatgct      120

tcaactaact ccagtaattc cttggtggta cgaacatcca atgaagcaca caagtttgtt      180

tgcttttcgt gcatgatatt aaatagcttg gcagcaacag gactaggatg agtagcagca      240

cgttccttat atgtagcttt cgacatgatt tatcttcgtt tcctgcaggt ttttgttctg      300

tgcagttggg ttaagaatac tgggcaattt catgtttctt caacactaca tatgcgtata      360

tataccaatc taagtctgtg ctccttcctt cgttcttcct tctgttcgga gattaccgaa      420

tcaaaaaaat ttcaaagaaa ccgaaatcaa aaaaaagaat aaaaaaaaaa tgatgaattg      480

aattgaaaag ctagcttatc gatgataagc tgtcaaagat gagaattaat tccacggact      540

atagactata ctagatactc cgtctactgt acgatacact tccgctcagg tccttgtcct      600

ttaacgaggc cttaccactc ttttgttact ctattgatcc agctcagcaa aggcagtgtg      660

atctaagatt ctatcttcgc gatgtagtaa aactagctag accgagaaag agactagaaa      720

tgcaaaaggc acttctacaa tggctgccat cattattatc cgatgtgacg ctgcagcttc      780

tcaatgatat tcgaatacgc tttgaggaga tacagcctaa tatccgacaa actgttttac      840

agatttacga tcgtacttgt tacccatcat tgaattttga acatccgaac ctgggagttt      900

tccctgaaac agatagtata tttgaacctg tataataata tatagtctag cgctttacgg      960

aagacaatgt atgtatttcg gttcctggag aaactattgc atctattgca taggtaatct     1020

tgcacgtcgc atccccggtt cattttctgc gtttccatct tgcacttcaa tagcatatct     1080

ttgttcgctt gcctgtaact tacacgcgcc tcgtatcttt taatgatgga ataatttggg     1140

aatttactct gtgtttattt atttttatgt tttgtatttg gattttagaa agtaaataaa     1200

gaaggtagaa gagttacgga atgaagaaaa aaaaataaac aaaggtttaa aaaatttcaa     1260

caaaaagcgt actttacata tatatttatt agacaagaaa agcagattaa atagatatac     1320

attcgattaa cgataagtaa aatgtaaaat cacaggattt tcgtgtgtgg tcttctacac     1380

agacaagatg aaacaattcg gcattaatac ctgagagcag gaagagcaag ataaaaggta     1440

gtatttgttg gcgatccccc tagagtcttt tacatcttcg gaaaacaaaa actatttttt     1500

ctttaatttc tttttttact ttctattttt aatttatata tttatattaa aaaatttaaa     1560

ttataattat ttttatagca cgtgatgaaa aggaccggga agctccaccc cggttgataa     1620

tcagaaaagc cccaaaaaca ggaagattgt ataagcaaat atttaaattg taaacgttaa     1680

tattttgtta aaattcgcgt taaatttttg ttaaatcagc tcatttttta acgaatagcc     1740

cgaaatcggc aaaatccctt ataaatcaaa agaatagacc gagatagggt tgagtgttgt     1800

tccagtttcc aacaagagtc cactattaaa gaacgtggac tccaacgtca aagggcgaaa     1860

aagggtctat cagggcgatg gcccactacg tgaaccatca ccctaatcaa gttttttggg     1920

gtcgaggtgc cgtaaagcag taaatcggaa gggtaaacgg atgcccccat ttagagcttg     1980

acggggaaag ccggcgaacg tggcgagaaa ggaagggaag aaagcgaaag gagcgggggc     2040

tagggcggtg ggaagtgtag gggtcacgct gggcgtaacc accacacccg ccgcgcttaa     2100

tggggcgcta cagggcgcgt ggggatgatc cactagtacg gattagaagc cgccgagcgg     2160

gtgacagccc tccgaaggaa gactctcctc cgtgcgtcct cgtcttcacc ggtcgcgttc     2220

ctgaaacgca gatgtgcctc gcgccgcact gctccgaaca ataaagattc tacaatacta     2280

gcttttatgg ttatgaagag gaaaaattgg cagtaacctg gccccacaaa ccttcaaatg     2340

aacgaatcaa attaacaacc ataggatgat aatgcgatta gttttttagc cttatttctg     2400

gggtaattaa tcagcgaagc gatgattttt gatctattaa cagatatata aatgcaaaaa     2460

ctgcataacc actttaacta atactttcaa cattttcggt ttgtattact tcttattcaa     2520

atgtaataaa agtatcaaca aaaaattgtt aatatacctc tatactttaa cgtcaaggag     2580

aaaaaacccc ggatcggact actagcagct gtaatacgac tcactatagg gaatattaag     2640

cttaaacaat gaggcaggtt tggttctctt ggattgtggg attgttccta tgttttttca     2700

acgtgtcttc tgctgctcca gtcaacacta caacagaaga tgaaacggca caaattccgg     2760

ctgaagctgt catcggttac tcagatttag aaggggattt cgatgttgct gttttgccat     2820

tttccaacag cacaaataac gggttattgt ttataaatac tactattgcc agcattgctg     2880

ctaaagaaga aggggtatct ctcgagaaaa gagaggctga agctatgcca tgggaaaact     2940

tcttgaagtg cttctcccaa tatatcccaa acaacgagac taacttaaag ttagtttaca     3000

ctcaaaacaa tccattatac atgtctgtct taaactctac tattcataac ttaagattta     3060

cttccgatcg gacccctaag ccattggtta tcgtcacccc atctcacgtc tcccatatcc     3120

aaggtactat cttatgttct aagaaggttg gtttgcaaat ccgtactaga tctggtggtc     3180

acgactctga aggtatgtcc tatatctctc aagagccatt tgtcattgtt gacttaagaa     3240

atatgagatc cattaaaatt gatgttcatt ctcaaactgc ttgggtcgaa gctggtgcca     3300

ccttgggtga agtttactac tgggtcaacg aaaaaaacga aaacttatct ttagctgccg     3360

gttactgtcc aaccgtctgt gctggtggtc atttcggtgg tggtggttac ggtccattga     3420

tgcgtaacta cggtttagct gctgacaaca ttattgacgc tcatttagtt aatgttcacg     3480

gtaaggtttt ggacagaaaa tctatgggtg aagatttatt ttgggccttg agaggtggtg     3540

gtgctgaatc cttcggtatc atcgttgcct ggaagattcg tttagttgct gtcccttcta     3600

agtccaccat gttctccgtc aagaaaatca tggaaattca tgagttggtc aaattggtta     3660

acaagtggca aaacatcgct tacaagtatg acaaggattt gttgttaatg actcacttca     3720

tcacccgtaa tatcaccgac aaccaaggta agaacaaaac tgctattcac acctacttct     3780

cctccgtttt tttgggtggt gtcgactcct tagtcgattt gatgaacaaa tcctttccag     3840

aattgggtat taagaaaact gattgtagac aattgtcttg gattgacacc attatcttct     3900

attctggtgt cgttaactac gacaccgaca actttaacaa ggaaattttg ttggatcgtt     3960

ctgctggtca aaatatcgcc ttcaaaatca aattggacta cgtcaaaaag ccaatcccag     4020

aaagggtttt cgttcaaatt ttggaaaagt tgtacgaaga agacattggt gtgggtatgt     4080

atgctttgta tccatatggt ggtatcatgg acgaaatttc cgaatctgcc atcccattcc     4140

cacacagagc tggtatttta tatgaattgt ggtacatctg ttcttgggaa aagcaagaag     4200

acaacgaaaa gcatttaaac tggattagaa acatttacaa cttcatgacc ccatacgttt     4260

ctaagaaccc aagaggcgcc tatttgaact accgtgactt agatattggt attaatgacc     4320

caaagaaccc aaacaactat actcaagcca gaatttgggg tgaaaagtac ttcggtaaga     4380

acttcgatag attagttaag gttaaaactt tggtcgatcc aaacaacttc ttcagaaacg     4440

aacaatccat cccaccattg ccaagacatc gtcacggcca tcatcaccat caccattagc     4500

tcgagcatgc atctagaggg ccgcatcatg taattagtta tgtcacgctt acattcacgc     4560

cctcccccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc     4620

cctatttatt tttttatagt tatgttagta ttaagaacgt tatttatatt tcaaattttt     4680

cttttttttc tgtacagacg cgtgtacgca tgtaacatta tactgaaaac cttgcttgag     4740

aaggttttgg gacgctcgaa ggctttaatt tgcggccctg cattaatgaa tcggccaacg     4800

cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca ctgactcgct     4860

gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg taatacggtt     4920

atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc agcaaaagcc     4980

caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga     5040

gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata     5100

ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac     5160

cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg     5220

taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc     5280

cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag     5340

acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt     5400

aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt     5460

atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg     5520

atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac     5580

gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca     5640

gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa ggatcttcac     5700

ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat atgagtaaac     5760

ttggtctgac agttaccaat gcttaatcag tgaggcacct atctcagcga tctgtctatt     5820

tcgttcatcc atagttgcct gactccccgt cgtgtagata actacgatac gggagcgctt     5880

accatctggc cccagtgctg caatgatacc gcgagaccca cgctcaccgg ctccagattt     5940

atcagcaata aaccagccag ccggaagggc cgagcgcaga agtggtcctg caactttatc     6000

cgcctccatt cagtctatta attgttgccg ggaagctaga gtaagtagtt cgccagttaa     6060

tagtttgcgc aacgttgttg gcattgctac aggcatcgtg gtgtcactct cgtcgtttgg     6120

tatggcttca ttcagctccg gttcccaacg atcaaggcga gttacatgat cccccatgtt     6180

gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt gtcagaagta agttggccgc     6240

agtgttatca ctcatggtta tggcagcact gcataattct cttactgtca tgccatccgt     6300

aagatgcttt tctgtgactg gtgagtactc aaccaagtca ttctgagaat agtgtatgcg     6360

gcgaccgagt tgctcttgcc cggcgtcaat acgggataat agtgtatcac atagcagaac     6420

tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga aaactctcaa ggatcttacc     6480

gctgttgaga tccagttcga tgtaacccac tcgtgcaccc aactgatctt cagcatcttt     6540

tactttcacc agcgtttctg ggtgagcaaa aacaggaagg caaaatgccg caaaaaaggg     6600

aataagggcg acacggaaat gttgaatact catactcttc ctttttcaat gggtaataac     6660

tgatataatt aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat     6720

acagtttttt agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg     6780

taacgttcac cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata     6840

ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg     6900

tctcccttgt catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct     6960

cttccaccca tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca     7020

atgtcaacag tacccttagt atattctcca gtagataggg agcccttgca tgacaattct     7080

gctaacatca aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg     7140

ctaacaatac ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt     7200

ctgtatacac ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg     7260

tcttcg                                                                7266


<210>  173
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 173 OXC158-I351G

<400>  173

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  174
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 174 OXC158-S367R(=CGG)

<400>  174

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Arg Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  175
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 175 OXC158-Q274G

<400>  175

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gly Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  176
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 176 OXC158-I351M

<400>  176

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Met Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  177
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 177 OXC158-V383A

<400>  177

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  178
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 178 OXC158-S367Q

<400>  178

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Gln Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  179
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 179 OXC158-S367N

<400>  179

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Asn Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  180
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Seq ID no. 180 OXC158-S367R(=AGG)

<400>  180

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Arg Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Val Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  181
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-L31E/V383G

<400>  181
atgccatggg aaaacttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca aaacaatcca gagtacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaacgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctaagtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat atcgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaatc tgttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtggtg gtatgtatgc tttgtatcca tatggtggta tcatggacga aatttccgaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattgccaa gacatcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  182
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-N138T/V383M/H515E

<400>  182
atgccatggg aaaacttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca aaacaatcca ttatacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaccgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctaagtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat atcgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaatc tgttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtatgg gtatgtatgc tttgtatcca tatggtggta tcatggacga aatttccgaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattgccaa gagagcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  183
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-S367K/V383A/P513V

<400>  183
atgccatggg aaaacttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca aaacaatcca ttatacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaacgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctaagtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat atcgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaaaa ggttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtgcgg gtatgtatgc tttgtatcca tatggtggta tcatggacga aatttccgaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattggtca gacatcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  184
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-V383A

<400>  184
atgccatggg aaaacttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca aaacaatcca ttatacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaacgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctaagtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat atcgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaatc tgttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtgcgg gtatgtatgc tttgtatcca tatggtggta tcatggacga aatttccgaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattgccaa gacatcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  185
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-W3A/L31E/K226M/S367Q/V383M/S399G/P513V

<400>  185
atgccagctg aaaacttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca aaacaatcca gagtacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaacgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctatgtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat atcgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaaca ggttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtatgg gtatgtatgc tttgtatcca tatggtggta tcatggacga aattggggaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattggtca gacatcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  186
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-I351G/V383A

<400>  186
atgccatggg aaaacttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca aaacaatcca ttatacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaacgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctaagtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat ggtgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaatc tgttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtgcgg gtatgtatgc tttgtatcca tatggtggta tcatggacga aatttccgaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattgccaa gacatcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  187
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-W3A/I351G/V383A

<400>  187
atgccagctg aaaacttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca aaacaatcca ttatacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaacgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctaagtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat ggtgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaatc tgttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtgcgg gtatgtatgc tttgtatcca tatggtggta tcatggacga aatttccgaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattgccaa gacatcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  188
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OXC158-W3A/N5Q/N28E/I351G/S367R/V383A

<400>  188
atgccagctg aacagttctt gaagtgcttc tcccaatata tcccaaacaa cgagactaac       60

ttaaagttag tttacactca agagaatcca ttatacatgt ctgtcttaaa ctctactatt      120

cataacttaa gatttacttc cgatcggacc cctaagccat tggttatcgt caccccatct      180

cacgtctccc atatccaagg tactatctta tgttctaaga aggttggttt gcaaatccgt      240

actagatctg gtggtcacga ctctgaaggt atgtcctata tctctcaaga gccatttgtc      300

attgttgact taagaaatat gagatccatt aaaattgatg ttcattctca aactgcttgg      360

gtcgaagctg gtgccacctt gggtgaagtt tactactggg tcaacgaaaa aaacgaaaac      420

ttatctttag ctgccggtta ctgtccaacc gtctgtgctg gtggtcattt cggtggtggt      480

ggttacggtc cattgatgcg taactacggt ttagctgctg acaacattat tgacgctcat      540

ttagttaatg ttcacggtaa ggttttggac agaaaatcta tgggtgaaga tttattttgg      600

gccttgagag gtggtggtgc tgaatccttc ggtatcatcg ttgcctggaa gattcgttta      660

gttgctgtcc cttctaagtc caccatgttc tccgtcaaga aaatcatgga aattcatgag      720

ttggtcaaat tggttaacaa gtggcaaaac atcgcttaca agtatgacaa ggatttgttg      780

ttaatgactc acttcatcac ccgtaatatc accgacaacc aaggtaagaa caaaactgct      840

attcacacct acttctcctc cgtttttttg ggtggtgtcg actccttagt cgatttgatg      900

aacaaatcct ttccagaatt gggtattaag aaaactgatt gtagacaatt gtcttggatt      960

gacaccatta tcttctattc tggtgtcgtt aactacgaca ccgacaactt taacaaggaa     1020

attttgttgg atcgttctgc tggtcaaaat ggtgccttca aaatcaaatt ggactacgtc     1080

aaaaagccaa tcccagaacg ggttttcgtt caaattttgg aaaagttgta cgaagaagac     1140

attggtgcgg gtatgtatgc tttgtatcca tatggtggta tcatggacga aatttccgaa     1200

tctgccatcc cattcccaca cagagctggt attttatatg aattgtggta catctgttct     1260

tgggaaaagc aagaagacaa cgaaaagcat ttaaactgga ttagaaacat ttacaacttc     1320

atgaccccat acgtttctaa gaacccaaga ggcgcctatt tgaactaccg tgacttagat     1380

attggtatta atgacccaaa gaacccaaac aactatactc aagccagaat ttggggtgaa     1440

aagtacttcg gtaagaactt cgatagatta gttaaggtta aaactttggt cgatccaaac     1500

aacttcttca gaaacgaaca atccatccca ccattgccaa gacatcgtca cggccatcat     1560

caccatcacc attag                                                      1575


<210>  189
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-L31E/V383G

<400>  189

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Glu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Gly Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  190
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-N138T/V383M/H515E

<400>  190

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Thr Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Met Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg Glu Arg His Gly His His His His His His 
        515                 520                 


<210>  191
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-S367K/V383A/P513V

<400>  191

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Lys Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Val Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  192
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-V383A

<400>  192

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  193
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-W3A/L31E/K226M/S367Q/V383M/S399G/P513V

<400>  193

Met Pro Ala Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Glu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Met Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Ile Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Gln Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Met Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Gly Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Val Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  194
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-I351G/V383A

<400>  194

Met Pro Trp Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  195
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-W3A/I351G/V383A

<400>  195

Met Pro Ala Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  196
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OXC158-W3A/N5Q/N28E/I351G/S367R/V383A

<400>  196

Met Pro Ala Glu Gln Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Glu Thr Asn Leu Lys Leu Val Tyr Thr Gln Glu Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Ser Asp 
        35                  40                  45              


Arg Thr Pro Lys Pro Leu Val Ile Val Thr Pro Ser His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Ser Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Glu Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Ser Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Asn Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Ala Gly Gln Asn Gly Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Arg Val 
        355                 360                 365             


Phe Val Gln Ile Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Ala Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Gly Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


<210>  197
<211>  9706
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 197 pCAS(G418)-GRN248

<400>  197
tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc       60

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga      120

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct      180

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg      240

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag      300

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat      360

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac      420

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac      480

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc      540

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt      600

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc      660

ttttctacac tagtcgaagc atctgtgctt cattttgtag aacaaaaatg caacgcgaga      720

gcgctaattt ttcaaacaaa gaatctgagc tgcattttta cagaacagaa atgcaacgcg      780

aaagcgctat tttaccaacg aagaatctgt gcttcatttt tgtaaaacaa aaatgcaacg      840

cgagagcgct aatttttcaa acaaagaatc tgagctgcat ttttacagaa cagaaatgca      900

acgcgagagc gctattttac caacaaagaa tctatacttc ttttttgttc tacaaaaatg      960

catcccgaga gcgctatttt tctaacaaag catcttagat tacttttttt ctcctttgtg     1020

cgctctataa tgcagtctct tgataacttt ttgcactgta ggtccgttaa ggttagaaga     1080

aggctacttt ggtgtctatt ttctcttcca taaaaaaagc ctgactccac ttcccgcgtt     1140

tactgattac tagcgaagct gcgggtgcat tttttcaaga taaaggcatc cccgattata     1200

ttctataccg atgtggattg cgcatacttt gtgaacagaa agtgatagcg ttgatgattc     1260

ttcattggtc agaaaattat gaacggtttc ttctattttg tctctatata ctacgtatag     1320

gaaatgttta cattttcgta ttgttttcga ttcactctat gaatagttct tactacaatt     1380

tttttgtcta aagagtaata ctagagataa acataaaaaa tgtagaggtc gagtttagat     1440

gcaagttcaa ggagcgaaag gtggatgggt aggttatata gggatatagc acagagatat     1500

atagcaaaga gatacttttg agcaatgttt gtggaagcgg tattcgcaat attttagtag     1560

ctcgttacag tccggtgcgt ttttggtttt ttgaaagtgc gtcttcagag cgcttttggt     1620

tttcaaaagc gctctgaagt tcctatactt tctagagaat aggaacttcg gaataggaac     1680

ttcaaagcgt ttccgaaaac gagcgcttcc gaaaatgcaa cgcgagctgc gcacatacag     1740

ctcactgttc acgtcgcacc tatatctgcg tgttgcctgt atatatatat acatgagaag     1800

aacggcatag tgcgtgttta tgcttaaatg cgtatatgtg ttatgtagta tactctttct     1860

tcaacaatta aatactctcg gtagccaagt tggtttaagg cgcaagactg taatttatca     1920

ctacgaaatc ttgagatcgg gcgttcgact cgcccccggg agagatggcc ggcatggtcc     1980

cagcctcctc gctggcgccg gctgggcaac accttcgggt ggcgaatggg actttgtagc     2040

ccaacaggag cacatgtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta     2100

tcaacttgaa aaagtggcac cgagtcggtg ctttttttat tttttgtcac tattgttatg     2160

taaaatgcca cctctgacag tatggaacgc aaacttctgt ctagtggata taggtctaga     2220

gatctgtttc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     2280

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     2340

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     2400

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     2460

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     2520

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     2580

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     2640

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     2700

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     2760

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     2820

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     2880

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     2940

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     3000

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtcccgcggt     3060

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     3120

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     3180

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     3240

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     3300

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     3360

tcttcagctt gcctcgtccc cgccgggtca cccggccagc gacatggagg cccagaatac     3420

cctccttgac agtcttgacg tgcgcagctc aggggcatga tgtgactgtc gcccgtacat     3480

ttagcccata catccccatg tataatcatt tgcatccata cattttgatg gccgcacggc     3540

gcgaagcaaa aattacggct cctcgctgca gacctgcgag cagggaaacg ctcccctcac     3600

agacgcgttg aattgtcccc acgccgcgcc cctgtagaga aatataaaag gttaggattt     3660

gccactgagg ttcttctttc atatacttcc ttttaaaatc ttgctaggat acagttctca     3720

catcacatcc gaacataaac aaccatgggt aaggaaaaga ctcacgtttc gaggccgcga     3780

ttaaattcca acatggatgc tgatttatat gggtataaat gggctcgcga taatgtcggg     3840

caatcaggtg cgacaatcta tcgattgtat gggaagcccg atgcgccaga gttgtttctg     3900

aaacatggca aaggtagcgt tgccaatgat gttacagatg agatggtcag actaaactgg     3960

ctgacggaat ttatgcctct tccgaccatc aagcatttta tccgtactcc tgatgatgca     4020

tggttactca ccactgcgat ccccggcaaa acagcattcc aggtattaga agaatatcct     4080

gattcaggtg aaaatattgt tgatgcgctg gcagtgttcc tgcgccggtt gcattcgatt     4140

cctgtttgta attgtccttt taacagcgat cgcgtatttc gtctcgctca ggcgcaatca     4200

cgaatgaata acggtttggt tgatgcgagt gattttgatg acgagcgtaa tggctggcct     4260

gttgaacaag tctggaaaga aatgcataag cttttgccat tctcaccgga ttcagtcgtc     4320

actcatggtg atttctcact tgataacctt atttttgacg aggggaaatt aataggttgt     4380

attgatgttg gacgagtcgg aatcgcagac cgataccagg atcttgccat cctatggaac     4440

tgcctcggtg agttttctcc ttcattacag aaacggcttt ttcaaaaata tggtattgat     4500

aatcctgata tgaataaatt gcagtttcat ttgatgctcg atgagttttt ctaatcagta     4560

ctgacaataa aaagattctt gttttcaaga acttgtcatt tgtatagttt ttttatattg     4620

tagttgttct attttaatca aatgttagcg tgatttatat tttttttcgc ctcgacatca     4680

tctgcccaga tgcgaagtta agtgcgcaga aagtaatatc atgcgtcaat cgtatgtgaa     4740

tgctggtcgc tatactgctg tcgattcgat actaacgccg ccatccagtg tcgaaaacga     4800

gctctcgaga acccttaatc atagcttcaa aatgtttcta ctcctttttt actcttccag     4860

attttctcgg actccgcgca tcgccgtacc acttcaaaac acccaagcac agcatactaa     4920

atttcccctc tttcttcctc tagggtgtcg ttaattaccc gtactaaagg tttggaaaag     4980

aaaaaagagg ccgcctcgtt tctttttctt cgtcgaaaaa ggcaataaaa atttttatca     5040

cgtttctttt tcttgaaaat tttttttttt gatttttttc tctttcgatg acctcccatt     5100

gatatttaag ttaataaacg gtcttcaatt tctcaagttt cagtttcatt tttcttgttc     5160

tattacaact ttttttactt cttgctcatt agaaagaaag catagcaatc taatctaagt     5220

tttctagatg gattataaag atgacgatga caaacctcca aaaaagaaga gaaaggtcga     5280

taagaaatac tcaataggct tagatatcgg cacaaatagc gtcggatggg cggtgatcac     5340

tgatgaatat aaggttccgt ctaaaaagtt caaggttctg ggaaatacag accgccacag     5400

tatcaaaaaa aatcttatag gggctctttt atttgacagt ggagagacag cggaagcgac     5460

tcgtctcaaa cggacagctc gtagaaggta tacacgtcgg aagaatcgta tttgttatct     5520

acaggagatt ttttcaaatg agatggcgaa agtagatgat agtttctttc atcgacttga     5580

agagtctttt ttggtggaag aagacaagaa gcatgaacgt catcctattt ttggaaatat     5640

agtagatgaa gttgcttatc atgagaaata tccaactatc tatcatctgc gaaaaaaatt     5700

ggtagattct acttataaag cggatttgcg cttaatctat ttggccttag cgcatatgat     5760

taagtttcgt ggtcattttt tgattgaggg agatttaaat cctgataata gtgatgtgga     5820

caaactattt atccagttgg tacaaaccta caatcaatta tttgaagaaa accctattaa     5880

cgcaagtgga gtagatgcta aagcgattct ttctgcacga ttgagtaaat caagacgatt     5940

agaaaatctc attgctcagc tccccggtga gaagaaaaat ggcttatttg ggaatctcat     6000

tgctttgtca ttgggtttga cccctaattt taaatcaaat tttgatttgg cagaagatgc     6060

taaattacag ctttcaaaag atacttacga tgatgattta gataatttat tggcgcaaat     6120

tggagatcaa tatgctgatt tgtttttggc agctaagaat ttatcagatg ctattttact     6180

ttcagatatc ctaagagtaa atactgaaat aactaaggct cccctatcag cttcaatgat     6240

taaacgctac gatgaacatc atcaagactt gactctttta aaagctttag ttcgacaaca     6300

acttccagaa aagtataaag aaatcttttt tgatcaatca aaaaacggat atgcaggtta     6360

tattgatggg ggagctagcc aagaagaatt ttataaattt atcaaaccaa ttttagaaaa     6420

aatggatggt actgaggaat tattggtgaa actaaatcgt gaagatttgc tgcgcaagca     6480

acggaccttt gacaacggct ctattaccca tcaaattcac ttgggtgagc tgcatgctat     6540

tttgagaaga caagaagact tttatccatt tttaaaagac aatcgtgaga agattgaaaa     6600

aatcttgact tttcgaattc cttattatgt tggtccattg gcgcgtggca atagtcgttt     6660

tgcatggatg actcggaagt ctgaagaaac aattacccca tggaattttg aagaagttgt     6720

cgataaaggt gcttcagctc aatcatttat tgaacgcatg acaaactttg ataaaaatct     6780

tccaaatgaa aaagtactac caaaacatag tttgctttat gagtatttta cggtttataa     6840

cgaattgaca aaggtcaaat atgttactga aggaatgcga aaaccagcat ttctttcagg     6900

tgaacagaag aaagccattg ttgatttact cttcaaaaca aatcgaaaag taaccgttaa     6960

gcaattaaaa gaagattatt tcaaaaaaat agaatgtttt gatagtgttg aaatttcagg     7020

agttgaagat agatttaatg cttcattagg tacctaccat gatttgctaa aaattattaa     7080

agataaagat tttttggata atgaagaaaa tgaagatatc ttagaggata ttgttttaac     7140

attgacctta tttgaagata gggagatgat tgaggaaaga cttaaaacat atgctcacct     7200

ctttgatgat aaggtgatga aacagcttaa acgtcgccgt tatactggtt ggggacgttt     7260

gtctcgaaaa ttgattaatg gtattaggga taagcaatct ggcaaaacaa tattagattt     7320

tttgaaatca gatggttttg ccaatcgcaa ttttatgcag ctgatccatg atgatagttt     7380

gacatttaaa gaagacattc aaaaagcaca agtgtctgga caaggcgata gtttacatga     7440

acatattgca aatttagctg gtagccctgc tattaaaaaa ggtattttac agactgtaaa     7500

agttgttgat gaattggtca aagtaatggg gcggcataag ccagaaaata tcgttattga     7560

aatggcacgt gaaaatcaga caactcaaaa gggccagaaa aattcgcgag agcgtatgaa     7620

acgaatcgaa gaaggtatca aagaattagg aagtcagatt cttaaagagc atcctgttga     7680

aaatactcaa ttgcaaaatg aaaagctcta tctctattat ctccaaaatg gaagagacat     7740

gtatgtggac caagaattag atattaatcg tttaagtgat tatgatgtcg atcacattgt     7800

tccacaaagt ttccttaaag acgattcaat agacaataag gtcttaacgc gttctgataa     7860

aaatcgtggt aaatcggata acgttccaag tgaagaagta gtcaaaaaga tgaaaaacta     7920

ttggagacaa cttctaaacg ccaagttaat cactcaacgt aagtttgata atttaacgaa     7980

agctgaacgt ggaggtttga gtgaacttga taaagctggt tttatcaaac gccaattggt     8040

tgaaactcgc caaatcacta agcatgtggc acaaattttg gatagtcgca tgaatactaa     8100

atacgatgaa aatgataaac ttattcgaga ggttaaagtg attaccttaa aatctaaatt     8160

agtttctgac ttccgaaaag atttccaatt ctataaagta cgtgagatta acaattacca     8220

tcatgcccat gatgcgtatc taaatgccgt cgttggaact gctttgatta agaaatatcc     8280

aaaacttgaa tcggagtttg tctatggtga ttataaagtt tatgatgttc gtaaaatgat     8340

tgctaagtct gagcaagaaa taggcaaagc aaccgcaaaa tatttctttt actctaatat     8400

catgaacttc ttcaaaacag aaattacact tgcaaatgga gagattcgca aacgccctct     8460

aatcgaaact aatggggaaa ctggagaaat tgtctgggat aaagggcgag attttgccac     8520

agtgcgcaaa gtattgtcca tgccccaagt caatattgtc aagaaaacag aagtacagac     8580

aggcggattc tccaaggagt caattttacc aaaaagaaat tcggacaagc ttattgctcg     8640

taaaaaagac tgggatccaa aaaaatatgg tggttttgat agtccaacgg tagcttattc     8700

agtcctagtg gttgctaagg tggaaaaagg gaaatcgaag aagttaaaat ccgttaaaga     8760

gttactaggg atcacaatta tggaaagaag ttcctttgaa aaaaatccga ttgacttttt     8820

agaagctaaa ggatataagg aagttaaaaa agacttaatc attaaactac ctaaatatag     8880

tctttttgag ttagaaaacg gtcgtaaacg gatgctggct agtgccggag aattacaaaa     8940

aggaaatgag ctggctctgc caagcaaata tgtgaatttt ttatatttag ctagtcatta     9000

tgaaaagttg aagggtagtc cagaagataa cgaacaaaaa caattgtttg tggagcagca     9060

taagcattat ttagatgaga ttattgagca aatcagtgaa ttttctaagc gtgttatttt     9120

agcagatgcc aatttagata aagttcttag tgcatataac aaacatagag acaaaccaat     9180

acgtgaacaa gcagaaaata ttattcattt atttacgttg acgaatcttg gagctcccgc     9240

tgcttttaaa tattttgata caacaattga tcgtaaacga tatacgtcta caaaagaagt     9300

tttagatgcc actcttatcc atcaatccat cactggtctt tatgaaacac gcattgattt     9360

gagtcagcta ggaggtgacc ctccaaaaaa gaagagaaag gtctgagcgg atctcttatg     9420

tctttacgat ttatagtttt cattatcaag tatgcctata ttagtatata gcatctttag     9480

atgacagtgt tcgaagtttc acgaataaaa gataatattc tactttttgc tcccaccgcg     9540

tttgctagca cgagtgaaca ccatccctcg cctgtgagtt gtacccattc ctctaaactg     9600

tagacatggt agcttcagca gtgttcgtta tgtacggcat cctccaacaa acagtcggtt     9660

atagtttgtc ctgctcctct gaatcgagtc cctcgatatt tctcat                    9706


<210>  198
<211>  3690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO. 198 pSmGAL2:OXC158

<400>  198
ctgcagtaga atcagtggaa ggagaatgcg ccttaatggg tagtgcttga cacgcagcag       60

gccagataag aaccgcctgt gaagtttaga tgatattcgc tgaagcataa ctaattagtt      120

tatttgtgtg aaggaatagt gacgttgtga tgcggtgagt tcggcggtta ggggaatggt      180

atatgataaa aaacggaaac gtgcttcttt aatttaattg tttaatattg ttgcagatat      240

ataaaaaggg ggaaagaacc aaagatgtaa ttatttcttt attgcctcaa cctaaagcaa      300

gcaataaggt atagagatca ggacgtctcg agagctgata tcaaatttga agccacgcaa      360

gtaactacgt aggtcagagg gcacaaggaa taacacgtga cattacggat cagaggagtt      420

ctccagatct gaatcacgat gatttcggaa aacacagggc aaagagaaac aaggtagccg      480

cactcaattc atcttttagt gactactttt catcgaaatc caattaaatg cagtagaatc      540

tgttcaaaaa aatgtacata gtgtcaattc ggcaagcttt cttccggaat ggcttaacca      600

gaccatatat ctcttcatta ttttcatttt aaggtccgga gtattgatca cgtgatcaaa      660

ttcccattga agggttgcct tttaaaggca ccggtagtca ctcatccgtg cggagtgttc      720

tgcgccattc aggggccaat gtgcctttga gaagattaga gcagggagca gactcggggc      780

ggaccactcc gagccgatgt tagttaagcc ttcccatctt gaaataggaa caaaatggct      840

ttatactcct gccagaaagc aaggcatgtg tataccttct caagaatata caacgttttg      900

gcagctattg ttcagaagag ggatagatcg taagctaaaa tttggagaaa ttaaagattt      960

gtagacatat ataaactatc agcaattcac tgctaaaata catcttgaga gtaactcttc     1020

gcttattcat cttgttcact tttcgatgaa gaaaaccact gttaagtaaa ataaagaata     1080

acatataaaa aactttttca taatgaggca ggtttggttc tcttggattg tgggattgtt     1140

cctatgtttt ttcaacgtgt cttctgctgc tccagtcaac actacaacag aagatgaaac     1200

ggcacaaatt ccggctgaag ctgtcatcgg ttactcagat ttagaagggg atttcgatgt     1260

tgctgttttg ccattttcca acagcacaaa taacgggtta ttgtttataa atactactat     1320

tgccagcatt gctgctaaag aagaaggggt atctctcgag aaaagagagg ctgaagctat     1380

gccatgggaa aacttcttga agtgcttctc ccaatatatc ccaaacaacg agactaactt     1440

aaagttagtt tacactcaaa acaatccatt atacatgtct gtcttaaact ctactattca     1500

taacttaaga tttacttccg atcggacccc taagccattg gttatcgtca ccccatctca     1560

cgtctcccat atccaaggta ctatcttatg ttctaagaag gttggtttgc aaatccgtac     1620

tagatctggt ggtcacgact ctgaaggtat gtcctatatc tctcaagagc catttgtcat     1680

tgttgactta agaaatatga gatccattaa aattgatgtt cattctcaaa ctgcttgggt     1740

cgaagctggt gccaccttgg gtgaagttta ctactgggtc aacgaaaaaa acgaaaactt     1800

atctttagct gccggttact gtccaaccgt ctgtgctggt ggtcatttcg gtggtggtgg     1860

ttacggtcca ttgatgcgta actacggttt agctgctgac aacattattg acgctcattt     1920

agttaatgtt cacggtaagg ttttggacag aaaatctatg ggtgaagatt tattttgggc     1980

cttgagaggt ggtggtgctg aatccttcgg tatcatcgtt gcctggaaga ttcgtttagt     2040

tgctgtccct tctaagtcca ccatgttctc cgtcaagaaa atcatggaaa ttcatgagtt     2100

ggtcaaattg gttaacaagt ggcaaaacat cgcttacaag tatgacaagg atttgttgtt     2160

aatgactcac ttcatcaccc gtaatatcac cgacaaccaa ggtaagaaca aaactgctat     2220

tcacacctac ttctcctccg tttttttggg tggtgtcgac tccttagtcg atttgatgaa     2280

caaatccttt ccagaattgg gtattaagaa aactgattgt agacaattgt cttggattga     2340

caccattatc ttctattctg gtgtcgttaa ctacgacacc gacaacttta acaaggaaat     2400

tttgttggat cgttctgctg gtcaaaatat cgccttcaaa atcaaattgg actacgtcaa     2460

aaagccaatc ccagaatctg ttttcgttca aattttggaa aagttgtacg aagaagacat     2520

tggtgtgggt atgtatgctt tgtatccata tggtggtatc atggacgaaa tttccgaatc     2580

tgccatccca ttcccacaca gagctggtat tttatatgaa ttgtggtaca tctgttcttg     2640

ggaaaagcaa gaagacaacg aaaagcattt aaactggatt agaaacattt acaacttcat     2700

gaccccatac gtttctaaga acccaagagg cgcctatttg aactaccgtg acttagatat     2760

tggtattaat gacccaaaga acccaaacaa ctatactcaa gccagaattt ggggtgaaaa     2820

gtacttcggt aagaacttcg atagattagt taaggttaaa actttggtcg atccaaacaa     2880

cttcttcaga aacgaacaat ccatcccacc attgccaaga catcgtcacg gccatcatca     2940

ccatcaccat tagctcgagc atgcatctag agggccgcat catgtaatta gttatgtcac     3000

gcttacattc acgccctccc cccacatccg ctctaaccga aaaggaagga gttagacaac     3060

ctgaagtcta ggtccctatt tattttttta tagttatgtt agtattaaga acgttattta     3120

tatttcaaat ttttcttttt tttctgtaca gacgcgtgta cgcatgtaac attatactga     3180

aaaccttgct tgagaaggtt ttgggacgct cgaaggcttt aatttgccgt atgttactgt     3240

ttctggtagt tgatatgaag ttggagttgt atattgtacg ctttaggaac agggaagtga     3300

atattattta ctctgctgca cattctggct aggtcgaagc cggaacttga gaagacgccg     3360

cgctagaact atggaccaag ctgttgacaa tgttcagatg gtgatgcact accctgtgcg     3420

gggagtggcc acggacgcga gcggaaggtg cggaaggtgc ggaaggtgcg ggagttgcgg     3480

gaggttcttc gctaagcgtg agggttgcta gctggggcgg cggggtttcc ctaagtgtaa     3540

ataaggcctc ggctggcaca tgagtcgccg gaggaggcgg cggaggcgac gacgctaaaa     3600

ccgtggccgt tggggaagga tgggcggcta tatctaccat tgacctgatg gggactcggt     3660

tcttaaggaa tgggtttgag gtgggtgtgg                                      3690


<210>  199
<211>  8989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO. 199 pACC1::pPGK1:ACC1

<400>  199
gcgcatgcat cgacgtcaca gtgagctcag gccgcatcac ggccgttacg ccctccagag       60

tcaccacgac tgcgactagt atcatccgtc aagaagaaca agaacaagaa caagaacaag      120

aacaacaaac tccgggcaca tctctcggct tcagtcgctt tcgctcattg cctgtaggtt      180

ggcccgatat gcgttgacgt tatccaaagg ggaatgcttc atcttgttga acaacgccca      240

acaatttcca ctgcccaccg aatcgttgcg cccgttaaaa tcttcacatg gcccggccgc      300

gcgcgcgttg tgccaacaag tcgcagtcga aattcaaccg ctcattgcca ctctctctac      360

tgcttggtga actaggctat acgctcaatc agcgccaaga tatataagaa gaacagcact      420

cccagtcgta ttctggcaca gtatagccta gcacaatcac tgtcacaatt gttatcggtt      480

ctacaattgt tctgctctct tcaattttcc tttccttatt ctactctttt tatccctacg      540

cacagatatt ataacatctg cataataggc atttgcaaga attactcgtg agtaaggaaa      600

gagtgaggaa ctatcgcata cctgcattta aagatgccga tttgggcgcg aatcctttat      660

tttggcttca ccctcatact attatcaggg ccagaaaaag gaagtgtttc cctccttctt      720

gaattgatgt taccctcata aagcacgtgg cctcttatcg agaaagaaat taccgtcgct      780

cgtgatttgt ttgcaaaaag aacaaaactg aaaaaaccca gacacgctcg acttcctgtc      840

ttcctattga ttgcagcttc caatttcgtc acacaacaag gtcctagcga cggctcacag      900

gttttgtaac aagcaatcga aggttctgga atggcgggaa agggtttagt accacatgct      960

atgatgccca ctgtgatctc cagagcaaag ttcgttcgat cgtactgtta ctctctctct     1020

ttcaaacaga attgtccgaa tcgtgtgaca acaacagcct gttctcacac actcttttct     1080

tctaaccaag ggggtggttt agtttagtag aacctcgtga aacttacatt tacatatata     1140

taaacttgca taaattggtc aatgcaagaa atacatattt ggtcttttct aattcgtagt     1200

ttttcaagtt cttagatgct ttctttttct cttttttaca gatcatcaag gaagtaatta     1260

tctacttttt acaacaaata taaaacaatg agcgaagaaa gcttattcga gtcttctcca     1320

cagaagatgg agtacgaaat tacaaactac tcagaaagac atacagaact tccaggtcat     1380

ttcattggcc tcaatacagt agataaacta gaggagtccc cgttaaggga ctttgttaag     1440

agtcacggtg gtcacacggt catatccaag atcctgatag caaataatgg tattgccgcc     1500

gtgaaagaaa ttagatccgt cagaaaatgg gcatacgaga cgttcggcga tgacagaacc     1560

gtccaattcg tcgccatggc caccccagaa gatctggagg ccaacgcaga atatatccgt     1620

atggccgatc aatacattga agtgccaggt ggtactaata ataacaacta cgctaacgta     1680

gacttgatcg tagacatcgc cgaaagagca gacgtagacg ccgtatgggc tggctggggt     1740

cacgcctccg agaatccact attgcctgaa aaattgtccc agtctaagag gaaagtcatc     1800

tttattgggc ctccaggtaa cgccatgagg tctttaggtg ataaaatctc ctctaccatt     1860

gtcgctcaaa gtgctaaagt cccatgtatt ccatggtctg gtaccggtgt tgacaccgtt     1920

cacgtggacg agaaaaccgg tctggtctct gtcgacgatg acatctatca aaagggttgt     1980

tgtacctctc ctgaagatgg tttacaaaag gccaagcgta ttggttttcc tgtcatgatt     2040

aaggcatccg aaggtggtgg tggtaaaggt atcagacaag ttgaacgtga agaagatttc     2100

atcgctttat accaccaggc agccaacgaa attccaggct cccccatttt catcatgaag     2160

ttggccggta gagcgcgtca cttggaagtt caactgctag cagatcagta cggtacaaat     2220

atttccttgt tcggtagaga ctgttccgtt cagagacgtc atcaaaaaat tatcgaagaa     2280

gcaccagtta caattgccaa ggctgaaaca tttcacgaga tggaaaaggc tgccgtcaga     2340

ctggggaaac tagtcggtta tgtctctgcc ggtaccgtgg agtatctata ttctcatgat     2400

gatggaaaat tctacttttt agaattgaac ccaagattac aagtcgagca tccaacaacg     2460

gaaatggtct ccggtgttaa cttacctgca gctcaattac aaatcgctat gggtatccct     2520

atgcatagaa taagtgacat tagaacttta tatggtatga atcctcattc tgcctcagaa     2580

atcgatttcg aattcaaaac tcaagatgcc accaagaaac aaagaagacc tattccaaag     2640

ggtcattgta ccgcttgtcg tatcacatca gaagatccaa acgatggatt caagccatcg     2700

ggtggtactt tgcatgaact aaacttccgt tcttcctcta atgtttgggg ttacttctcc     2760

gtgggtaaca atggtaatat tcactccttt tcggactctc agttcggcca tatttttgct     2820

tttggtgaaa atagacaagc ttccaggaaa cacatggttg ttgccctgaa ggaattgtcc     2880

attaggggtg atttcagaac tactgtggaa tacttgatca aacttttgga aactgaagat     2940

ttcgaggata acactattac caccggttgg ttggacgatt tgattactca taaaatgacc     3000

gctgaaaagc ctgatccaac tcttgccgtc atttgcggtg ccgctacaaa ggctttctta     3060

gcatctgaag aagcccgcca caagtatatc gaatccttac aaaagggaca agttctatct     3120

aaagacctac tgcaaactat gttccctgta gattttatcc atgagggtaa aagatacaag     3180

ttcaccgtag ctaaatccgg taatgaccgt tacacattat ttatcaatgg ttctaaatgt     3240

gatatcatac tgcgtcaact atctgatggt ggtcttttga ttgccatagg cggtaaatcg     3300

cataccatct attggaaaga agaagttgct gctacaagat tatccgttga ctctatgact     3360

actttgttgg aagttgaaaa cgatccaacc cagttgcgta ctccatcccc tggtaaattg     3420

gttaaattct tggtggaaaa tggtgaacac attatcaagg gccaaccata tgcagaaatt     3480

gaagttatga aaatgcaaat gcctttggtt tctcaagaaa atggtatcgt ccagttatta     3540

aagcaacctg gttctaccat tgttgcaggt gatatcatgg ctattatgac tcttgacgat     3600

ccatccaagg tcaagcacgc tctaccattt gaaggtatgc tgccagattt tggttctcca     3660

gttatcgaag gaaccaaacc tgcctataaa ttcaagtcat tagtgtctac tttggaaaac     3720

attttgaagg gttatgacaa ccaagttatt atgaacgctt ccttgcaaca attgatagag     3780

gttttgagaa atccaaaact gccttactca gaatggaaac tacacatctc tgctttacat     3840

tcaagattgc ctgctaagct agatgaacaa atggaagagt tagttgcacg ttctttgaga     3900

cgtggtgctg ttttcccagc tagacaatta agtaaattga ttgatatggc cgtgaagaat     3960

cctgaataca accccgacaa attgctgggc gccgtcgtgg aaccattggc ggatattgct     4020

cataagtact ctaacgggtt agaagcccat gaacattcta tatttgtcca tttcttggaa     4080

gaatattacg aagttgaaaa gttattcaat ggtccaaatg ttcgtgagga aaatatcatt     4140

ctgaaattgc gtgatgaaaa ccctaaagat ctagataaag ttgcgctaac tgttttgtct     4200

cattcgaaag tttcagcgaa gaataacctg atcctagcta tcttgaaaca ttatcaacca     4260

ttgtgcaagt tatcttctaa agtttctgcc attttctcta ctcctctaca acatattgtt     4320

gaactagaat ctaaggctac cgctaaggtc gctctacaag caagagaaat tttgattcaa     4380

ggcgctttac cttcggtcaa ggaaagaact gaacaaattg aacatatctt aaaatcctct     4440

gttgtgaagg ttgcctatgg ctcatccaat ccaaagcgct ctgaaccaga tttgaatatc     4500

ttgaaggact tgatcgattc taattacgtt gtgttcgatg ttttacttca attcctaacc     4560

catcaagacc cagttgtgac tgctgcagct gctcaagtct atattcgtcg tgcttatcgt     4620

gcttacacca taggagatat tagagttcac gaaggtgtca cagttccaat tgttgaatgg     4680

aaattccaac taccttcagc tgcgttctcc acctttccaa ctgttaaatc taaaatgggt     4740

atgaacaggg ctgtttctgt ttcagatttg tcatatgttg caaacagtca gtcatctccg     4800

ttaagagaag gtattttgat ggctgtggat catttagatg atgttgatga aattttgtca     4860

caaagtttgg aagttattcc tcgtcaccaa tcttcttcta acggacctgc tcctgatcgt     4920

tctggtagct ccgcatcgtt gagtaatgtt gctaatgttt gtgttgcttc tacagaaggt     4980

ttcgaatctg aagaggaaat tttggtaagg ttgagagaaa ttttggattt gaataagcag     5040

gaattaatca atgcttctat ccgtcgtatc acatttatgt tcggttttaa agatgggtct     5100

tatccaaagt attatacttt taacggtcca aattataacg aaaatgaaac aattcgtcac     5160

attgagccgg ctttggcctt ccaactggaa ttaggaagat tgtccaactt caacattaaa     5220

ccaattttca ctgataatag aaacatccat gtctacgaag ctgttagtaa gacttctcca     5280

ttggataaga gattctttac aagaggtatt attagaacgg gtcatatccg tgatgacatt     5340

tctattcaag aatatctgac ttctgaagct aacagattga tgagtgatat attggataat     5400

ttagaagtca ccgacacttc aaattctgat ttgaatcata tcttcatcaa cttcattgcg     5460

gtgtttgata tctctccaga agatgtcgaa gccgccttcg gtggtttctt agaaagattt     5520

ggtaagagat tgttgagatt gcgtgtttct tctgccgaaa ttagaatcat catcaaagat     5580

cctcaaacag gtgccccagt accattgcgt gccttgatca ataacgtttc tggttatgtt     5640

atcaaaacag aaatgtacac cgaagtcaag aacgcaaaag gtgaatgggt atttaagtct     5700

ttgggtaaac ctggatccat gcatttaaga cctattgcta ctccttaccc tgttaaggaa     5760

tggttgcaac caaaacgtta taaggcacac ttgatgggta ccacatatgt ctatgacttc     5820

ccagaattat tccgccaagc atcgtcatcc caatggaaaa atttctctgc agatgttaag     5880

ttaacagatg atttctttat ttccaacgag ttgattgaag atgaaaacgg cgaattaact     5940

gaggtggaaa gagaacctgg tgccaacgct attggtatgg ttgcctttaa gattactgta     6000

aagactcctg aatatccaag aggccgtcaa tttgttgttg ttgctaacga tatcacattc     6060

aagatcggtt cctttggtcc acaagaagac gaattcttca ataaggttac tgaatatgct     6120

agaaagcgtg gtatcccaag aatttacttg gctgcaaact caggtgccag aattggtatg     6180

gctgaagaga ttgttccact atttcaagtt gcatggaatg atgctgccaa tccggacaag     6240

ggcttccaat acttatactt aacaagtgaa ggtatggaaa ctttaaagaa atttgacaaa     6300

gaaaattctg ttctcactga acgtactgtt ataaacggtg aagaaagatt tgtcatcaag     6360

acaattattg gttctgaaga tgggttaggt gtcgaatgtc tacgtggatc tggtttaatt     6420

gctggtgcaa cgtcaagggc ttaccacgat atcttcacta tcaccttagt cacttgtaga     6480

tccgtcggta tcggtgctta tttggttcgt ttgggtcaaa gagctattca ggtcgaaggc     6540

cagccaatta ttttaactgg tgctcctgca atcaacaaaa tgctgggtag agaagtttat     6600

acttctaact tacaattggg tggtactcaa atcatgtata acaacggtgt ttcacatttg     6660

actgctgttg acgatttagc tggtgtagag aagattgttg aatggatgtc ttatgttcca     6720

gccaagcgta atatgccagt tcctatcttg gaaactaaag acacatggga tagaccagtt     6780

gatttcactc caactaatga tgaaacttac gatgtaagat ggatgattga aggtcgtgag     6840

actgaaagtg gatttgaata tggtttgttt gataaagggt ctttctttga aactttgtca     6900

ggatgggcca aaggtgttgt cgttggtaga gcccgtcttg gtggtattcc actgggtgtt     6960

attggtgttg aaacaagaac tgtcgagaac ttgattcctg ctgatccagc taatccaaat     7020

agtgctgaaa cattaattca agaacctggt caagtttggc atccaaactc cgccttcaag     7080

actgctcaag ctatcaatga ctttaacaac ggtgaacaat tgccaatgat gattttggcc     7140

aactggagag gtttctctgg tggtcaacgt gatatgttca acgaagtctt gaagtatggt     7200

tcgtttattg ttgacgcatt ggtggattac aaacaaccaa ttattatcta tatcccacct     7260

accggtgaac taagaggtgg ttcatgggtt gttgtcgatc caactatcaa cgctgaccaa     7320

atggaaatgt atgccgacgt caacgctaga gctggtgttt tggaaccaca aggtatggtt     7380

ggtatcaagt tccgtagaga aaaattgctg gacaccatga acagattgga tgacaagtac     7440

agagaattga gatctcaatt atccaacaag agtttggctc cagaagtaca tcagcaaata     7500

tccaagcaat tagctgatcg tgagagagaa ctattgccaa tttacggaca aatcagtctt     7560

caatttgctg atttgcacga taggtcttca cgtatggtgg ccaagggtgt tatttctaag     7620

gaactggaat ggaccgaggc acgtcgtttc ttcttctgga gattgagaag aagattgaac     7680

gaagaatatt tgattaaaag gttgagccat caggtaggcg aagcatcaag attagaaaag     7740

atcgcaagaa ttagatcgtg gtaccctgct tcagtggacc atgaagatga taggcaagtc     7800

gcaacatgga ttgaagaaaa ctacaaaact ttggacgata aactaaaggg tttgaaatta     7860

gagtcattcg ctcaagactt agctaaaaag atcagaagcg accatgacaa tgctattgat     7920

ggattatctg aagttatcaa gatgttatct accgatgata aagaaaaatt gttgaagact     7980

ttgaaataaa ccttgtaaag taaaaaaaaa aaatagtatt gatgtaattt aatttagttg     8040

ctaatataaa ttagaaaata catacatata tatattatgc gcgttttctt tcataatccg     8100

ttctttttac ttagaatata ttatatatct gtgggaaggg gtacaacctt ttgcttttta     8160

gtgtcactgc ctatgtgatc ggtctgtttc ctcttttgct tggcgatggc gttggcgttt     8220

ttcaaagctt tttcttgagc tctgcagttt tccaagtact ctgaaggatc tgtttgagcg     8280

cttccatcat cgttcaattg ctttagtacg aaactaactt cttccgggct cttgcaacgg     8340

gcaaagtact gaaaaaagac tgattttccg gggacaattc tgcttaacat gtattttgta     8400

ttgccgatgt ggttgtcaaa cttcgttgcc cactgaataa actcgcgaca agcaacgacc     8460

caagatggac cgtcttctga aggcttagaa gtgtgatcaa aaactgtagg gtcccgttca     8520

gcacactctg caatcatacc accaatgtta gtgtttttcc aatgattcgc ttgtaaatca     8580

tgaaaatgag agcggtcgcg gatagcgccg ttcacaatca acgacacgtt atttgcctgg     8640

catatctcgt agatctccgc aatgtaatct gtgatgggct gctctctgtt tctcatttca     8700

gtcttcctgc agtgaactgt aagatttgtg atgcccgtgg cacacagacg tttgacgagc     8760

tgtagagtgt cttgcttggt gtccaagagt cttattttca cactgatggg tttgctgtga     8820

gggttaccca cgttcttaac cagttctttc aagatgagac acagtgtgtc tggggtgcgc     8880

aagagggcag agcccatgcc ggagtgtata gagaagtgtt tggggcagcc tgcattgata     8940

tctatcccgc tgacgtcgtt gatcactttc aaagcagcct gggtggcca                 8989


<210>  200
<211>  2709
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO. 200 pTEF1:CsOAC


<220>
<221>  misc_feature
<222>  (1)..(2709)
<223>  n is a or g or c or t

<400>  200
ttgttgggat tccattgtga ttaaggctat aatattaggt atgtagatat actagaagtt       60

ctcctcgagg atttaggaat ccataaaagg gaatctgcaa ttctacacaa ttctataaat      120

attattatca tcattttata tgttnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      240

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnttagta gatgatagtt gatttttatt      300

ccaacattat tgtactcagc aattgttgcg aaacagacaa gattaagtat attattcaag      360

gccttgctta cctagatgaa ccattgagaa atatacatat tgagcaatac ctctaggtcc      420

gaagttccgt gcctacaccc tttagtcaga tttagattat atgagataag tggtattttg      480

tggaccaagt ttgtgattaa tctgatatca agttactttc ttaacgacat taggacgcca      540

gggtagccag tattattcaa gtccatagaa cagcctgtat accttcactt cattaggtat      600

attcttggtt atgcgttatt taaatcctca tctgccgctg cttaaaaaaa gcagctaaag      660

tgttgcgtag gcaccttgcc aacagggagt tcttcagaga catggaggct caaaacgaaa      720

ttattgacag cctagacatc aatagtcata caacagaaag cgaccaccca actttggctg      780

ataatagcgt ataaacaatg catactttgt acgttcaaaa tacaatgcag tagatatatt      840

tatgcatatt acatataata catatcacat aggaagcaac aggcgcgttg gacttttaat      900

tttcgaggac cgcgaatcct tacatcacac ccaatccccc acaagtgatc ccccacacac      960

catagcttca aaatgtttct actccttttt tactcttcca gattttctcg gactccgcgc     1020

atcgccgtac cacttcaaaa cacccaagca cagcatacta aatttcccct ctttcttcct     1080

ctagggtgtc gttaattacc cgtactaaag gtttggaaaa gaaaaaagac accgcctcgt     1140

ttctttttct tcgtcgaaaa aggcaataaa aatttttatc acgtttcttt ttcttgaaaa     1200

tttttttttt tgattttttt ctctttcgat gacctcccat tgatatttaa gttaataaac     1260

ggtcatcaat ttctcaagtt tcagtttcat ttttcttgtt ctattacaac tttttttact     1320

tcttgctcat tagaaagaaa gcatagcaat ctaatctaag ttttaattac aaaatggccg     1380

tcaagcactt gatcgtctta aagtttaagg acgagatcac tgaagcccaa aaggaagaat     1440

tcttcaaaac ttacgttaac ttggttaaca tcattcctgc tatgaaggac gtctactggg     1500

gtaaggatgt cactcaaaaa aacaaggaag aaggttatac ccacatcgtt gaagtcacct     1560

tcgaatctgt tgaaactatt caagactaca tcattcaccc agctcacgtc ggtttcggtg     1620

atgtttacag atctttctgg gaaaaattgt tgatcttcga ctacacccca agaaagggct     1680

aaagtgcttt taactaagaa ttattagtct tttctgctta ttttttcatc atagtttaga     1740

acactttata ttaacgaata gtttatgaat ctatttaggt ttaaaaattg atacagtttt     1800

ataagttact ttttcaaaga ctcgtgctgt ctattgcata atgcactgga aggggaaaaa     1860

aaaggtgcac acgcgtggct ttttcttgaa tttgcagttt gaaaaataac tacatggatg     1920

ataagaaaac atggagtaca gtcactttga gaaccttcaa tcagctggta acgtcttcgt     1980

taattggata ctcaaaaaag atggatagca tgaatcacaa gatggaagga aatgcgggcc     2040

acgaccacag tgatatgcat atgggagatg gagatgatac cttccgttaa ttcgggtttc     2100

aatcacttcg tttgtctatc gtatcgcagc ctagtgaata tttaattctt tcaataaaaa     2160

aggcttaaaa tcaccatgaa aatcacaaga ggaatctttc aacaagaaca atagtataca     2220

atccatgaat gaaggagttc atatttgact agaactatac aaaggttttg tactgttttt     2280

actgtgaggg tagcatctca tttatccaga atctcagaag ggagaaaccc aatcgctaaa     2340

tcgatattat cacccagaag tttcaaatag gcgattgtag aatatacaca gggacaacca     2400

ctcagtttat ggcttcagtg cgcgcccagt tctggaggaa agcattatcg aagtaataaa     2460

actttaaaaa agctctccgc aactaatgag gattgcagta tccagatacc cttgttttct     2520

gccaaatgaa cacttttact atgtcatata aacaaaaagt gccatttctt ggtactgctt     2580

cagtcttagg aatggtcaat acgttattat tacttaaata tacgattaat aacatgctct     2640

gttgcgtatt tagtaagtgt gtaaggaaac tgtaatatta cctaaccggt atcccacgtg     2700

tttcacgaa                                                             2709


<210>  201
<211>  4288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO. 201 pGAL1:CsAAE1

<400>  201
ctgatcgcta agggagccaa ttcggtcaat gattcgatgg ttactgtggt gttgtcagca       60

ttagacaaaa gcgtcaatag cggcgtcagc gcgggagtat cagcaatatt tttcatggcg      120

ccaaaaatat catccaagga gctgttcgga gccgtcaaag cggaccctaa tattgtcaaa      180

atagggccta tctgcgggat caccttgctt acattgatgt gtttgatatc ggcttcaccg      240

atgtatatat tcgttaaggg tttgtagttg gcggtggagc cagcagtggc tacaataacc      300

aatatcagtg tggtgaacat gaataaaagg cacacagaca atatcgtcca aataattccc      360

ttcgacaggg gggtacggtg cttttcgatc ctcatgtttt tgttgttttc tttgctttcc      420

taactcttcg tatgaggatt ttcgatggag caggatgagg agaaatagta ccacatgtat      480

atatccatta caaaaaggtt tatatacaat tacaatagac ccttgttggg gtttctgaaa      540

aaagaagtag tcgatgccat cggcaataat acggaattac gagaaacaca atcccgatcc      600

ttttttgggt aattacttca ccgattctac cgatttatca tgccaaaaaa aattcaccgt      660

gggttctaga agtgcccttt gaggattgta gccactctaa cccacacggc ctccttacta      720

gctgactaag gtgacaaaac cgcaaggact ggaaagtcgc cactcatctg aaaattctca      780

agtttttcac tactgagttt atgctttcga atttttttgt tcggtaatag cacggcggtt      840

cgattccgga ttagaagccg ccgagcgggt gacagccctc cgaaggaaga ctctcctccg      900

tgcgtcctcg tcttcaccgg tcgcgttcct gaaacgcaga tgtgcctcgc gccgcactgc      960

tccgaacaat aaagattcta caatactagc ttttatggtt atgaagagga aaaattggca     1020

gtaacctggc cccacaaacc ttcaaatgaa cgaatcaaat taacaaccat aggatgataa     1080

tgcgattagt tttttagcct tatttctggg gtaattaatc agcgaagcga tgatttttga     1140

tctattaaca gatatataaa tgcaaaaact gcataaccac tttaactaat actttcaaca     1200

ttttcggttt gtattacttc ttattcaaat gtaataaaag tatcaacaaa aaattgttaa     1260

tatacctcta tactttaacg tcaaggagat gggtaaaaac tataagtctt tagactccgt     1320

tgtcgcctcc gactttattg ctttgggtat cacctccgaa gttgctgaaa ctttacacgg     1380

tagattagct gagattgttt gtaactacgg tgccgccact ccacaaactt ggattaatat     1440

cgctaaccat attttgtctc cagacttacc attctccttg catcaaatgt tgttttacgg     1500

ttgttataaa gattttggtc cagctcctcc agcttggatc ccagatcctg aaaaagttaa     1560

gtctactaac ttaggtgctt tgttagaaaa aagaggtaaa gaattcttgg gtgttaagta     1620

taaagatcca atctcttcct tctctcattt tcaagaattc tccgttagaa acccagaagt     1680

ttattggaga accgttttga tggacgaaat gaagatctcc ttctctaagg atcctgaatg     1740

tattttgaga cgtgacgata tcaacaatcc aggtggttct gaatggttac caggtggtta     1800

tttgaactct gctaaaaatt gtttgaacgt caattccaac aaaaaattga acgacaccat     1860

gattgtttgg agagacgaag gtaacgatga cttaccatta aacaagttga ccttggacca     1920

attgagaaag cgtgtctggt tggtcggtta cgccttggag gaaatgggtt tggaaaaagg     1980

ttgtgccatc gctatcgata tgccaatgca cgtcgacgcc gtcgttatct atttggccat     2040

cgttttagct ggttacgtcg tcgtctccat cgctgactct ttctccgctc cagaaatttc     2100

cactagattg agattatcca aggccaaggc tattttcact caagatcaca ttattagagg     2160

taagaagcgt attccattgt actccagagt cgtcgaagcc aagtctccta tggccattgt     2220

tatcccatgt tctggttcta acattggtgc tgaattgaga gatggtgaca tttcctggga     2280

ctatttcttg gaaagagcta aggaatttaa gaactgcgaa tttaccgcca gagaacaacc     2340

tgttgatgcc tacactaaca ttttgttctc ttctggtaca actggtgagc caaaggctat     2400

cccttggact caagctaccc cattaaaggc cgccgctgat ggttggtccc acttggacat     2460

tcgtaagggt gacgtcatcg tctggccaac taacttgggt tggatgatgg gtccatggtt     2520

agtttacgcc tctttgttaa acggtgcttc cattgccttg tacaacggtt ctccattggt     2580

ttctggtttc gctaagtttg tccaagacgc caaggttacc atgttaggtg ttgttccatc     2640

tatcgtcaga tcttggaagt ctactaactg tgtctctggt tacgattggt ctactatcag     2700

atgcttctct tcctctggtg aagcctctaa cgttgatgaa tatttgtggt tgatgggtcg     2760

tgccaactac aagccagtta tcgaaatgtg tggtggtaca gagatcggtg gtgctttttc     2820

cgctggttcc tttttgcaag ctcaatcttt gtcttctttc tcttctcaat gtatgggttg     2880

tactttgtat attttggata agaacggtta cccaatgcct aagaacaaac caggtatcgg     2940

tgaattagct ttgggtccag ttatgttcgg tgcttccaag accttgttga acggtaatca     3000

ccatgatgtc tatttcaaag gtatgccaac tttaaacggt gaagtcttga gacgtcacgg     3060

tgacatcttt gaattgactt ctaacggtta ctaccatgct cacggtagag ctgatgatac     3120

tatgaacatt ggtggtatta agatttcttc tatcgaaatc gaaagagttt gtaatgaagt     3180

tgacgacaga gtctttgaaa ccactgctat tggtgtccca ccattgggtg gtggtccaga     3240

acaattagtc attttcttcg ttttgaagga ttctaacgac actaccatcg acttaaacca     3300

attgagattg tctttcaact tgggtttgca aaagaagttg aacccattat ttaaagtcac     3360

tagagttgtt ccattgtctt ctttgccaag aaccgccacc aacaagatta tgagaagagt     3420

tttgagacaa caattttctc atttcgaagg ctgacgagca tgcatctaga gggccgcatc     3480

atgtaattag ttatgtcacg cttacattca cgccctcccc ccacatccgc tctaaccgaa     3540

aaggaaggag ttagacaacc tgaagtctag gtccctattt atttttttat agttatgtta     3600

gtattaagaa cgttatttat atttcaaatt tttctttttt ttctgtacag acgcgtgtac     3660

gcatgtaaca ttatactgaa aaccttgctt gagaaggttt tgggacgctc gaaggcttta     3720

atttgccaca cgactagcgc tttcagatat taaaaagttt agatgtaggt tttagcggta     3780

acagttatat aaatcgtgtt tcttctcttg atgaaacaaa aaaatgctag aaaaactttg     3840

tcgtttctta cttttggtgc gctttgcagt tttcgtggct agacttagaa tcatttctcc     3900

tcagatttct tgattaaagt ttggtgcgaa gccctactct aacattggtg ttcttctttt     3960

cattcacgca agttaagtcc aggaaggtga gcaaatgctc atccttctgt tcatgcgtga     4020

cggctgaatt atccttatct ggcgtacccg tgcagccgtt tccgtgcctc ggttcctccg     4080

agatatcctt agggaccgcc agggaccatg attgcgtcaa ctgttgtcac cgctccagag     4140

gatcctctgt aaccttttca accataaaaa tagaaagggc acagggttgg ggtatttgaa     4200

tttttttttt gggttttttc gtattactta ttacttacct tcttttctat ataattttgt     4260

ttttccctgg tagagcggaa tcttccca                                        4288


<210>  202
<211>  2516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO. 202 pGAL1:PKS73

<400>  202
cccaaagcta agagtcccat tttattcttc tatatgtata ttttcgatac tctaaaccac       60

cctacaatgt agccctatac taaatctgct caattttcag cttctacaag tgactcgaga      120

ccacgtggaa agatccaact actccagcac aacgattcaa tataatcgat tgctccactc      180

ataagaggca agaacaagct tcaacttttg gtaagccgcc gtttataaac agggaagatg      240

tcctttgtca agggaggcac agagcatggc caatttggca aattgcggat tagaagccgc      300

cgagcgggtg acagccctcc gaaggaagac tctcctccgt gcgtcctcgt cttcaccggt      360

cgcgttcctg aaacgcagat gtgcctcgcg ccgcactgct ccgaacaata aagattctac      420

aatactagct tttatggtta tgaagaggaa aaattggcag taacctggcc ccacaaacct      480

tcaaatgaac gaatcaaatt aacaaccata ggatgataat gcgattagtt ttttagcctt      540

atttctgggg taattaatca gcgaagcgat gatttttgat ctattaacag atatataaat      600

gcaaaaactg cataaccact ttaactaata ctttcaacat tttcggtttg tattacttct      660

tattcaaatg taataaaagt atcaacaaaa aattgttaat atacctctat actttaacgt      720

caaggagatg tctaacaaca acccgtacat tttgggcatt ggaacagccg ttcctaatga      780

gcccctaaag cagagtgagc tttcagccgt gatgtccaaa gatttctcat cagatccact      840

agtcgttgat aaggtcagta agatattcga acagagtcaa attaacacta gatatctata      900

tagaaaccct ttgagggagg agacggccct gagacataga aagaatgaaa atattaatga      960

cgtgaataga caatttcaaa aatgcgcccc ggatctgtcc cagagggcgt gcgaaaaagc     1020

gattaaggag tggggtggct caatacaaga tatcacgcat atagtctctg tctcttctac     1080

aggagtggtc gtgccggata taaattttgt cctaatccaa agacttgggt tgaataaaga     1140

tatcgagagg ttgagcgtca actttatggg atgtcttgct gggctatcaa gtatgagagc     1200

ggctgttcct ctggcgtcta agcacccgaa gaacagagtg cttgtagtgt gtactgaaat     1260

atgctccacc cacttcagca ccaaagaggg cgtcgatcaa attgttgcct ctacgatatt     1320

cgccgacggt tctgcagcat acatattagg gtgtaatccg accatatacg aacacccgtt     1380

gtttgaggtt attggtagca tgaccaggag cgtacctgac actgcgcaca ctatgacatg     1440

ggatattagt acggatgggt gggatctggg cttagaccag tcaataccgc accatatcgg     1500

cggtgggatt gaatcattcg taaacgacct tctagcgaaa aataagtctc aaactcagga     1560

tcttacgccg aaggagtgtg agtttcttat tcacactggc ggcaaagcta ttttaatgag     1620

cattgaacaa tctttgggaa ttacatcaaa acagaatcaa catagctggg atatttacag     1680

aaattatggt aacatgtcat ctgcctctgt gatcttcgta ctggaacatg cacgtcactc     1740

aaagtcattg cctcaatata gcattagtct ggcttttgga cccgggctgg ctttcgaagg     1800

gtgtgtatta aagaacatgg tgtgacgagc atgcatctag agggccgcat catgtaatta     1860

gttatgtcac gcttacattc acgccctccc cccacatccg ctctaaccga aaaggaagga     1920

gttagacaac ctgaagtcta ggtccctatt tattttttta tagttatgtt agtattaaga     1980

acgttattta tatttcaaat ttttcttttt tttctgtaca gacgcgtgta cgcatgtaac     2040

attatactga aaaccttgct tgagaaggtt ttgggacgct cgaaggcttt aatttgcgaa     2100

ttacaatagt atgtctgatg tctgcaagaa gtaacaggcg tgtgcacaag aatacgtgtg     2160

tgtgcgtaag cgtatgcact ggtggcataa cttatctaag aagtatatat cactgacata     2220

gaaatgtaga tatacaggta tttttctcga taatcgataa aaatctcgtc gcgctgaacc     2280

aaacttggtg gttacggaga gtttttctct catcattact gtctttcgca ttgatttccc     2340

ctttgaccga taaaatccct tggattcata agattaaaca aagaggtgat caaagagaac     2400

cctgtgaaag tttatgttta taaccgggca taaagtgaac tagacacttt caagaagcca     2460

accaaagcat gagtaacgaa gcttaccagc atgatcatac cgtaaatcct caccag         2516


<210>  203
<211>  3598
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO. 203 pTEF1:OXC52

<400>  203
gcagagaagg agcaaataag ccagttttaa ggaaccgaga taagctgttt tcgcccattg       60

ttctagttct acaaaatatc tacagggaat cgatgaggtt gtaagaaatc ctgaatactc      120

tatgatagtg cataacacta aaaagttgaa agaatcccgt atcatggacg atttccttga      180

acatttgagc aaagacgata acaaagcatg gtatggcgcg gaagaaaccg agagagctgc      240

aaaattagat gcaatagaaa cactacttat tacagatagt gtactaaaaa ggaacgacgt      300

gaaaaaacgt gaaaaatacc tagacctaat agagaatagt ggaaacaaca atggcaaaat      360

attcgtactc agtacttcaa aaatcacagt gagcaacttg acaaaccaac accttgccaa      420

cagggagttc ttcagagaca tggaggctca aaacgaaatt attgacagcc tagacatcaa      480

tagtcataca acagaaagcg accacccaac tttggctgat aatagcgtat aaacaatgca      540

tactttgtac gttcaaaata caatgcagta gatatattta tgcatattac atataataca      600

tatcacatag gaagcaacag gcgcgttgga cttttaattt tcgaggaccg cgaatcctta      660

catcacaccc aatcccccac aagtgatccc ccacacacca tagcttcaaa atgtttctac      720

tcctttttta ctcttccaga ttttctcgga ctccgcgcat cgccgtacca cttcaaaaca      780

cccaagcaca gcatactaaa tttcccctct ttcttcctct agggtgtcgt taattacccg      840

tactaaaggt ttggaaaaga aaaaagacac cgcctcgttt ctttttcttc gtcgaaaaag      900

gcaataaaaa tttttatcac gtttcttttt cttgaaaatt tttttttttg atttttttct      960

ctttcgatga cctcccattg atatttaagt taataaacgg tcatcaattt ctcaagtttc     1020

agtttcattt ttcttgttct attacaactt tttttacttc ttgctcatta gaaagaaagc     1080

atagcaatct aatctaagtt ttaattacaa aatgaggcag gtttggttct cttggattgt     1140

gggattgttc ctatgttttt tcaacgtgtc ttctgctgct ccagtcaaca ctacaacaga     1200

agatgaaacg gcacaaattc cggctgaagc tgtcatcggt tactcagatt tagaagggga     1260

tttcgatgtt gctgttttgc cattttccaa cagcacaaat aacgggttat tgtttataaa     1320

tactactatt gccagcattg ctgctaaaga agaaggggta tctctcgaga aaagagaggc     1380

tgaagctatg ccaagagaaa acttcttgaa gtgcttctcc caatatatcc caaacaacgc     1440

tactaactta aagttagttt acactcaaaa caatccatta tacatgtctg tcttaaactc     1500

tactattcat aacttaagat ttacttccga tactacccct aagccattgg ttatcgtcac     1560

cccatctcac gtctcccata tccaaggtac tatcttatgt tctaagaagg ttggtttgca     1620

aatccgtact agatctggtg gtcacgactc tgaaggtatg tcctatatct ctcaagtccc     1680

atttgtcatt gttgacttaa gaaatatgag atccattaaa attgatgttc attctcaaac     1740

tgcttgggtc gaagctggtg ccaccttggg tgaagtttac tactgggtca acgaaaaaaa     1800

cgaaaactta tctttagctg ccggttactg tccaaccgtc tgtgctggtg gtcatttcgg     1860

tggtggtggt tacggtccat tgatgcgtaa ctacggttta gctgctgaca acattattga     1920

cgctcattta gttaatgttc acggtaaggt tttggacaga aaatctatgg gtgaagattt     1980

attttgggcc ttgagaggtg gtggtgctga atccttcggt atcatcgttg cctggaagat     2040

tcgtttagtt gctgtcccta agtccaccat gttctccgtc aagaaaatca tggaaattca     2100

tgagttggtc aaattggtta acaagtggca aaacatcgct tacaagtatg acaaggattt     2160

gttgttaatg actcacttca tcacccgtaa tatcaccgac aaccaaggta agaacaaaac     2220

tgctattcac acctacttct cctccgtttt tttgggtggt gtcgactcct tagtcgattt     2280

gatgaacaaa tcctttccag aattgggtat taagaaaact gattgtagac aattgtcttg     2340

gattgacacc attatcttct attctggtgt cgttaactac gacaccgaca actttaacaa     2400

ggaaattttg ttggatcgtt ctgctggtca aaatggtgcc ttcaaaatca aattggacta     2460

cgtcaaaaag ccaatcccag aatctgtttt cgttcaaatt ttggaaaagt tgtacgaaga     2520

agacattggt gccggtatgt atgctttgta tccatatggt ggtatcatgg acgaaatttc     2580

cgaatctgcc atcccattcc cacacagagc tggtatttta tatgaattgt ggtacatctg     2640

ttcttgggaa aagcaagaag acaacgaaaa gcatttaaac tggattagaa acatttacaa     2700

cttcatgacc ccatacgttt ctaagaaccc aagattagcc tatttgaact accgtgactt     2760

agatattggt attaatgacc caaagaaccc aaacaactat actcaagcca gaatttgggg     2820

tgaaaagtac ttcggtaaga acttcgatag attagttaag gttaaaactt tggtcgatcc     2880

aaacaacttc ttcagaaacg aacaatccat cccaccattg ccaagacatc gtcacggcca     2940

tcatcaccat caccattagc tcgagcatgc atctagaggg ccgcatcatg taattagtta     3000

tgtcacgctt acattcacgc cctcccccca catccgctct aaccgaaaag gaaggagtta     3060

gacaacctga agtctaggtc cctatttatt tttttatagt tatgttagta ttaagaacgt     3120

tatttatatt tcaaattttt cttttttttc tgtacagacg cgtgtacgca tgtaacatta     3180

tactgaaaac cttgcttgag aaggttttgg gacgctcgaa ggctttaatt tgccaatagc     3240

ttgcagcgta gctaaactct aaaatttatc taaatcactc atataaaccg aacccttccc     3300

cttccgctta tagtacagta cctatacatt tcataaacat ggcatggcga tcagcgccaa     3360

acaatatgga aaatccacag aaagctattc attgaaaaaa tagtacaaat aagtcacatg     3420

atgatatttg attttattat atttttaaaa aaagtaaaaa ataaaaagta gtttattttt     3480

aaaaaataaa atttaaaata ttagtgtatt tgatttccga aagttaaaaa agaaatagta     3540

agaaatatat atttcattga atggatatat gaaacgttta ctggtggaag ttttgctc       3598


<210>  204
<211>  3601
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO: 204 pTEF1OXC154-S88AL451G

<400>  204
gcagagaagg agcaaataag ccagttttaa ggaaccgaga taagctgttt tcgcccattg       60

ttctagttct acaaaatatc tacagggaat cgatgaggtt gtaagaaatc ctgaatactc      120

tatgatagtg cataacacta aaaagttgaa agaatcccgt atcatggacg atttccttga      180

acatttgagc aaagacgata acaaagcatg gtatggcgcg gaagaaaccg agagagctgc      240

aaaattagat gcaatagaaa cactacttat tacagatagt gtactaaaaa ggaacgacgt      300

gaaaaaacgt gaaaaatacc tagacctaat agagaatagt ggaaacaaca atggcaaaat      360

attcgtactc agtacttcaa aaatcacagt gagcaacttg acaaaccaac accttgccaa      420

cagggagttc ttcagagaca tggaggctca aaacgaaatt attgacagcc tagacatcaa      480

tagtcataca acagaaagcg accacccaac tttggctgat aatagcgtat aaacaatgca      540

tactttgtac gttcaaaata caatgcagta gatatattta tgcatattac atataataca      600

tatcacatag gaagcaacag gcgcgttgga cttttaattt tcgaggaccg cgaatcctta      660

catcacaccc aatcccccac aagtgatccc ccacacacca tagcttcaaa atgtttctac      720

tcctttttta ctcttccaga ttttctcgga ctccgcgcat cgccgtacca cttcaaaaca      780

cccaagcaca gcatactaaa tttcccctct ttcttcctct agggtgtcgt taattacccg      840

tactaaaggt ttggaaaaga aaaaagacac cgcctcgttt ctttttcttc gtcgaaaaag      900

gcaataaaaa tttttatcac gtttcttttt cttgaaaatt tttttttttg atttttttct      960

ctttcgatga cctcccattg atatttaagt taataaacgg tcatcaattt ctcaagtttc     1020

agtttcattt ttcttgttct attacaactt tttttacttc ttgctcatta gaaagaaagc     1080

atagcaatct aatctaagtt ttaattacaa aatgaggcag gtttggttct cttggattgt     1140

gggattgttc ctatgttttt tcaacgtgtc ttctgctgct ccagtcaaca ctacaacaga     1200

agatgaaacg gcacaaattc cggctgaagc tgtcatcggt tactcagatt tagaagggga     1260

tttcgatgtt gctgttttgc cattttccaa cagcacaaat aacgggttat tgtttataaa     1320

tactactatt gccagcattg ctgctaaaga agaaggggta tctctcgaga aaagagaggc     1380

tgaagctatg ccaagagaaa acttcttgaa gtgcttctcc caatatatcc caaacaacgc     1440

tactaactta aagttagttt acactcaaaa caatccatta tacatgtctg tcttaaactc     1500

tactattcat aacttaagat ttacttccga tactacccct aagccattgg ttatcgtcac     1560

cccatctcac gtctcccata tccaaggtac tatcttatgt tctaagaagg ttggtttgca     1620

aatccgtact agatctggtg gtcacgacgc tgaaggtatg tcctatatct ctcaagtccc     1680

atttgtcatt gttgacttaa gaaatatgag atccattaaa attgatgttc attctcaaac     1740

tgcttgggtc gaagctggtg ccaccttggg tgaagtttac tactgggtca acgaaaaaaa     1800

cgaaaactta tctttagctg ccggttactg tccaaccgtc tgtgctggtg gtcatttcgg     1860

tggtggtggt tacggtccat tgatgcgtaa ctacggttta gctgctgaca acattattga     1920

cgctcattta gttaatgttc acggtaaggt tttggacaga aaatctatgg gtgaagattt     1980

attttgggcc ttgagaggtg gtggtgctga atccttcggt atcatcgttg cctggaagat     2040

tcgtttagtt gctgtccctt ctaagtccac catgttctcc gtcaagaaaa tcatggaaat     2100

tcatgagttg gtcaaattgg ttaacaagtg gcaaaacatc gcttacaagt atgacaagga     2160

tttgttgtta atgactcact tcatcacccg taatatcacc gacaaccaag gtaagaacaa     2220

aactgctatt cacacctact tctcctccgt ttttttgggt ggtgtcgact ccttagtcga     2280

tttgatgaac aaatcctttc cagaattggg tattaagaaa actgattgta gacaattgtc     2340

ttggattgac accattatct tctattctgg tgtcgttaac tacgacaccg acaactttaa     2400

caaggaaatt ttgttggatc gttctgctgg tcaaaatggt gccttcaaaa tcaaattgga     2460

ctacgtcaaa aagccaatcc cagaatctgt tttcgttcaa attttggaaa agttgtacga     2520

agaagacatt ggtgccggta tgtatgcttt gtatccatat ggtggtatca tggacgaaat     2580

ttccgaatct gccatcccat tcccacacag agctggtatt ttatatgaat tgtggtacat     2640

ctgttcttgg gaaaagcaag aagacaacga aaagcattta aactggatta gaaacattta     2700

caacttcatg accccatacg tttctaagaa cccaagaggt gcctatttga actaccgtga     2760

cttagatatt ggtattaatg acccaaagaa cccaaacaac tatactcaag ccagaatttg     2820

gggtgaaaag tacttcggta agaacttcga tagattagtt aaggttaaaa ctttggtcga     2880

tccaaacaac ttcttcagaa acgaacaatc catcccacca ttgccaagac atcgtcacgg     2940

ccatcatcac catcaccatt agctcgagca tgcatctaga gggccgcatc atgtaattag     3000

ttatgtcacg cttacattca cgccctcccc ccacatccgc tctaaccgaa aaggaaggag     3060

ttagacaacc tgaagtctag gtccctattt atttttttat agttatgtta gtattaagaa     3120

cgttatttat atttcaaatt tttctttttt ttctgtacag acgcgtgtac gcatgtaaca     3180

ttatactgaa aaccttgctt gagaaggttt tgggacgctc gaaggcttta atttgccaat     3240

agcttgcagc gtagctaaac tctaaaattt atctaaatca ctcatataaa ccgaaccctt     3300

ccccttccgc ttatagtaca gtacctatac atttcataaa catggcatgg cgatcagcgc     3360

caaacaatat ggaaaatcca cagaaagcta ttcattgaaa aaatagtaca aataagtcac     3420

atgatgatat ttgattttat tatattttta aaaaaagtaa aaaataaaaa gtagtttatt     3480

tttaaaaaat aaaatttaaa atattagtgt atttgatttc cgaaagttaa aaaagaaata     3540

gtaagaaata tatatttcat tgaatggata tatgaaacgt ttactggtgg aagttttgct     3600

c                                                                     3601


<210>  205
<211>  3390
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO. 205 pGAL1:OXC157

<400>  205
gcagagaagg agcaaataag ccagttttaa ggaaccgaga taagctgttt tcgcccattg       60

ttctagttct acaaaatatc tacagggaat cgatgaggtt gtaagaaatc ctgaatactc      120

tatgatagtg cataacacta aaaagttgaa agaatcccgt atcatggacg atttccttga      180

acatttgagc aaagacgata acaaagcatg gtatggcgcg gaagaaaccg agagagctgc      240

aaaattagat gcaatagaaa cactacttat tacagatagt gtactaaaaa ggaacgacgt      300

gaaaaaacgt gaaaaatacc tagacctaat agagaatagt ggaaacaaca atggcaaaat      360

attcgtactc agtacttcaa aaatcacagt gagcaacttg acaaaccaac acggattaga      420

agccgccgag cgggtgacag ccctccgaag gaagactctc ctccgtgcgt cctcgtcttc      480

accggtcgcg ttcctgaaac gcagatgtgc ctcgcgccgc actgctccga acaataaaga      540

ttctacaata ctagctttta tggttatgaa gaggaaaaat tggcagtaac ctggccccac      600

aaaccttcaa atgaacgaat caaattaaca accataggat gataatgcga ttagtttttt      660

agccttattt ctggggtaat taatcagcga agcgatgatt tttgatctat taacagatat      720

ataaatgcaa aaactgcata accactttaa ctaatacttt caacattttc ggtttgtatt      780

acttcttatt caaatgtaat aaaagtatca acaaaaaatt gttaatatac ctctatactt      840

taacgtcaag gagaaaaaac cccggatcgg actactagca gctgtaatac gactcactat      900

agggaatatt aagcttaaac aatgaggcag gtttggttct cttggattgt gggattgttc      960

ctatgttttt tcaacgtgtc ttctgctgct ccagtcaaca ctacaacaga agatgaaacg     1020

gcacaaattc cggctgaaga ggtcatcggt tactcagatt tagaagggga tttcgatgtt     1080

gctgttttgc cattttccaa cagcacaaat aacgggttat tgtttataaa tactactatt     1140

gccagcattg ctgctaaaga agaaggggta tctctcgaga aaagagaggc tgaagctatg     1200

ccaggggaaa acttcttgaa gtgcttctcc caatatatcc caaacaacga gactaactta     1260

aagttagttt acactcaaaa caatccatta tacatgtctg tcttaaactc tactattcat     1320

aacttaagat ttacttccga tactacccct aagccattgg ttatcgtcac cccaacgcac     1380

gtctcccata tccaaggtac tatcttatgt tctaagaagg ttggtttgca aatccgtact     1440

agatctggtg gtcacgactc tgaaggtatg tcctatatct ctcaagtccc atttgtcatt     1500

gttgacttaa gaaatatgag atccattaaa attgatgttc attctcaaac tgcttgggtc     1560

gaagctggtg ccaccttggg tgaagtttac tactgggtca acgaaaaaaa cgaaaactta     1620

tctttagctg ccggttactg tccaaccgtc tgtgctggtg gtcatttcgg tggtggtggt     1680

tacggtccat tgatgcgtaa ctacggttta gctgctgaca acattattga cgctcattta     1740

gttaatgttc acggtaaggt tttggacaga aaatctatgg gtgaagattt attttgggcc     1800

ttgagaggtg gtggtgctga atccttcggt atcatcgttg cctggaagat tcgtttagtt     1860

gctgtccctt ctaagtccac catgttctcc gtcaagaaaa tcatggaaat tcatgagttg     1920

gtcaaattgg ttaacaagtg gcaaaacatc gcttacaagt atgacaagga tttgttgtta     1980

atgactcact tcatcacccg taatatcacc gacaaccaag gtaagaacaa aactgctatt     2040

cacacctact tctcctccgt ttttttgggt ggtgtcgact ccttagtcga tttgatgaac     2100

aaatcctttc cagaattggg tattaagaaa actgattgta gacaattgtc ttggattgac     2160

accattatct tctattctgg tgtcgttaac tacgacaccg acaactttaa caaggaaatt     2220

ttgttggatc gttctgctgg tcaaaatatc gccttcaaaa tcaaattgga ctacgtcaaa     2280

aagccaatcc cagaatctgt tttcgttcaa attttggaaa agttgtacga agaagacatt     2340

ggtgtgggta tgtatgcttt gtatccatat ggtggtatca tggacgaaat ttccgaatct     2400

gccatcccat tcccacacag agctggtatt ttatatgaat tgtggtacat ctgttcttgg     2460

gaaaagcaag aagacaacga aaagcattta aactggatta gaaacattta caacttcatg     2520

accccatacg tttctaagaa cccaagaggc gcctatttga actaccgtga cttagatatt     2580

ggtattaatg acccaaagaa cccaaacaac tatactcaag ccagaatttg gggtgaaaag     2640

tacttcggta agaacttcga tagattagtt aaggttaaaa ctttggtcga tccaaacaac     2700

ttcttcagaa acgaacaatc catcccacca ttgccaagac atcgtcacgg cctcgagcat     2760

gcatctagag ggccgcatca tgtaattagt tatgtcacgc ttacattcac gccctccccc     2820

cacatccgct ctaaccgaaa aggaaggagt tagacaacct gaagtctagg tccctattta     2880

tttttttata gttatgttag tattaagaac gttatttata tttcaaattt ttcttttttt     2940

tctgtacaga cgcgtgtacg catgtaacat tatactgaaa accttgcttg agaaggtttt     3000

gggacgctcg aaggctttaa tttgccaata gcttgcagcg tagctaaact ctaaaattta     3060

tctaaatcac tcatataaac cgaacccttc cccttccgct tatagtacag tacctataca     3120

tttcataaac atggcatggc gatcagcgcc aaacaatatg gaaaatccac agaaagctat     3180

tcattgaaaa aatagtacaa ataagtcaca tgatgatatt tgattttatt atatttttaa     3240

aaaaagtaaa aaataaaaag tagtttattt ttaaaaaata aaatttaaaa tattagtgta     3300

tttgatttcc gaaagttaaa aaagaaatag taagaaatat atatttcatt gaatggatat     3360

atgaaacgtt tactggtgga agttttgctc                                      3390


<210>  206
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SEQ ID NO:206 (His Tag)

<400>  206

His His His His His His 
1               5       


<210>  207
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OCX154 Mutant/Variant (generalized)


<220>
<221>  MISC_FEATURE
<222>  (1)..(524)
<223>  Xaa is any amino acid

<400>  207

Met Xaa Xaa Glu Asn Phe Leu Lys Cys Phe Ser Gln Tyr Ile Pro Asn 
1               5                   10                  15      


Asn Xaa Thr Asn Xaa Lys Leu Val Tyr Xaa Gln Asn Asn Pro Leu Tyr 
            20                  25                  30          


Met Ser Val Leu Asn Ser Thr Ile His Asn Leu Arg Phe Thr Xaa Asp 
        35                  40                  45              


Xaa Thr Pro Lys Pro Leu Val Ile Val Thr Pro Xaa His Val Ser His 
    50                  55                  60                  


Ile Gln Gly Thr Ile Leu Cys Ser Lys Lys Val Gly Leu Gln Ile Arg 
65                  70                  75                  80  


Thr Arg Ser Gly Gly His Asp Xaa Glu Gly Met Ser Tyr Ile Ser Gln 
                85                  90                  95      


Xaa Pro Phe Val Ile Val Asp Leu Arg Asn Met Arg Ser Ile Lys Ile 
            100                 105                 110         


Asp Val His Ser Gln Thr Ala Trp Val Glu Ala Gly Ala Thr Leu Gly 
        115                 120                 125             


Glu Val Tyr Tyr Trp Val Asn Glu Lys Asn Glu Asn Leu Ser Leu Ala 
    130                 135                 140                 


Ala Gly Tyr Cys Pro Thr Val Cys Ala Gly Gly His Phe Gly Gly Gly 
145                 150                 155                 160 


Gly Tyr Gly Pro Leu Met Arg Asn Tyr Gly Leu Ala Ala Asp Asn Ile 
                165                 170                 175     


Ile Asp Ala His Leu Val Asn Val His Gly Lys Val Leu Asp Arg Lys 
            180                 185                 190         


Ser Met Gly Glu Asp Leu Phe Trp Ala Leu Arg Gly Gly Gly Ala Glu 
        195                 200                 205             


Ser Phe Gly Ile Ile Val Ala Trp Lys Ile Arg Leu Val Ala Val Pro 
    210                 215                 220                 


Xaa Lys Ser Thr Met Phe Ser Val Lys Lys Ile Met Glu Ile His Glu 
225                 230                 235                 240 


Leu Val Lys Leu Val Asn Lys Trp Gln Asn Ile Ala Tyr Lys Tyr Asp 
                245                 250                 255     


Lys Asp Leu Leu Leu Met Thr His Phe Ile Thr Arg Asn Ile Thr Asp 
            260                 265                 270         


Asn Gln Gly Lys Asn Lys Thr Ala Ile His Thr Tyr Phe Ser Ser Val 
        275                 280                 285             


Phe Leu Gly Gly Val Asp Ser Leu Val Asp Leu Met Asn Lys Ser Phe 
    290                 295                 300                 


Pro Glu Leu Gly Ile Lys Lys Thr Asp Cys Arg Gln Leu Ser Trp Ile 
305                 310                 315                 320 


Asp Thr Ile Ile Phe Tyr Ser Gly Val Val Xaa Tyr Asp Thr Asp Asn 
                325                 330                 335     


Phe Asn Lys Glu Ile Leu Leu Asp Arg Ser Xaa Gly Xaa Asn Xaa Ala 
            340                 345                 350         


Phe Lys Ile Lys Leu Asp Tyr Val Lys Lys Pro Ile Pro Glu Ser Val 
        355                 360                 365             


Phe Val Gln Xaa Leu Glu Lys Leu Tyr Glu Glu Asp Ile Gly Xaa Gly 
    370                 375                 380                 


Met Tyr Ala Leu Tyr Pro Tyr Gly Gly Ile Met Asp Glu Ile Ser Glu 
385                 390                 395                 400 


Ser Ala Ile Pro Phe Pro His Arg Ala Gly Ile Leu Tyr Glu Leu Trp 
                405                 410                 415     


Tyr Ile Cys Ser Trp Glu Lys Gln Glu Asp Asn Glu Lys His Leu Asn 
            420                 425                 430         


Trp Ile Arg Asn Ile Tyr Asn Phe Met Thr Pro Tyr Val Ser Lys Asn 
        435                 440                 445             


Pro Arg Xaa Ala Tyr Leu Asn Tyr Arg Asp Leu Asp Ile Gly Ile Asn 
    450                 455                 460                 


Asp Pro Lys Asn Pro Asn Asn Tyr Thr Gln Ala Arg Ile Trp Gly Glu 
465                 470                 475                 480 


Lys Tyr Phe Gly Lys Asn Phe Asp Arg Leu Val Lys Val Lys Thr Leu 
                485                 490                 495     


Val Asp Pro Asn Asn Phe Phe Arg Asn Glu Gln Ser Ile Pro Pro Leu 
            500                 505                 510         


Pro Arg His Arg His Gly His His His His His His 
        515                 520                 


