                         SEQUENCE LISTING

<110>  CC Biotech Ltd.
 
<120>  Polypeptides for treatment of bacterial infections

<130>  98013PCT1

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  186
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hydrolase domain

<400>  1

Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp Phe Asn 
1               5                   10                  15      


Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala Gly Tyr 
            20                  25                  30          


Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg Lys Ala 
        35                  40                  45              


Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr Ala Asn 
    50                  55                  60                  


Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn Met Leu 
65                  70                  75                  80  


Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu Glu Lys 
                85                  90                  95      


Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile Thr Ser 
            100                 105                 110         


Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe Tyr Thr 
        115                 120                 125             


Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ala His Val Arg Asn Arg 
    130                 135                 140                 


Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asn Tyr Gln Gly 
145                 150                 155                 160 


Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro Gly Val 
                165                 170                 175     


Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr 
            180                 185     


<210>  2
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hydrolase domain

<400>  2

Gln Gly Leu Lys Ile Asn Lys Ile Val Leu His His Asn Ala Gly Asn 
1               5                   10                  15      


Leu Ser Ile Gln Asp Cys Tyr Asn Val Trp Gln Thr Arg Glu Ala Ser 
            20                  25                  30          


Ala His Tyr Gln Val Gln Ser Asp Gly Arg Ile Gly Gln Leu Val Trp 
        35                  40                  45              


Asp Tyr Asp Thr Ala Trp His Ala Gly Asn Trp Asn Ala Asn Ala Thr 
    50                  55                  60                  


Ser Ile Gly Ile Glu His Ala Asp Ile Ser Thr Ser Pro Trp Gln Ile 
65                  70                  75                  80  


Ser Ala Gln Cys Leu Glu Asn Gly Ala His Leu Val Ala Ala Leu Cys 
                85                  90                  95      


Lys Leu Tyr Gly Leu Gly Arg Pro Thr Trp Met Lys Asn Val Phe Pro 
            100                 105                 110         


His Ser Tyr Phe Tyr Ala Thr Ala Cys Pro 
        115                 120         


<210>  3
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hydrolase domain

<400>  3

Leu Asn Gly Ile Asp Ile Ser Ser Tyr Gln Ser Ser Ile Asn Ile Ala 
1               5                   10                  15      


Ala Val Pro Ala Asp Phe Val Ile Val Lys Ala Thr Glu Gly Thr Gly 
            20                  25                  30          


Tyr Ile Asn Pro Cys Phe Arg Ala His Ala Asp Thr Ile Leu Asn Ser 
        35                  40                  45              


Gly Lys Leu Leu Gly Ile Tyr His Tyr Ile Ser Gly Ser Gly Trp Gln 
    50                  55                  60                  


Ala Glu Ala Glu Tyr Phe Val Asn Thr Val Lys Asp Tyr Ile Gly Arg 
65                  70                  75                  80  


Ala Val Leu Ala Leu Asp Phe Glu Ser Gly Gly Asn Ser Ala Tyr Gly 
                85                  90                  95      


Asp Thr Ala Tyr Leu Gln Gln Cys Ala Gln Thr Val Tyr Asn Leu Thr 
            100                 105                 110         


Gly Val His Pro Leu Ile Tyr Gly Ser Gln Arg Asp Tyr Gly Arg Leu 
        115                 120                 125             


Ala Ala Val Ser Lys Ala Thr Asn Cys Gly Leu Trp Val Ala Gln Tyr 
    130                 135                 140                 


Ala Asn Asn Asn His Thr Gly Tyr Gln Asn Lys Pro Trp Asn Glu Asp 
145                 150                 155                 160 


Ala Tyr Asp Cys Ala Ile Arg Gln Tyr Ser Ser Ser Gly Ser Leu Pro 
                165                 170                 175     


Asn Tyr Gly Gly Asn Leu Asp Leu Asn Lys Phe Tyr Gly Asp Ala Ala 
            180                 185                 190         


Ala Trp 
        


<210>  4
<211>  185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hydrolase domain

<400>  4

Ile Val Asp Val Tyr Ser Gly Ser Ser Asp Ser Ile Ile Gln Asp Pro 
1               5                   10                  15      


His Ala Asp Gly Val Ile Val Lys Ala Thr Gln Gly Thr Ser Tyr Val 
            20                  25                  30          


Asn Pro Arg Cys Asn His Gln Trp Asp Leu Ala Gly Gln Leu Gly Lys 
        35                  40                  45              


Leu Arg Gly Leu Tyr His Tyr Ala Gly Gly Gly Asn Pro Glu Ser Glu 
    50                  55                  60                  


Ala Gln Tyr Phe Ile Asn Asn Ile Lys Asn Tyr Val Gly Gln Gly Ile 
65                  70                  75                  80  


Leu Ile Leu Asp Trp Glu Ser Tyr Gln Asn Ser Ser Trp Gly Asp Thr 
                85                  90                  95      


Ser Trp Pro Leu Arg Phe Val Thr Glu Val His Arg Leu Thr Gly Val 
            100                 105                 110         


Trp Pro Leu Ile Tyr Val Gln Glu Ser Ala Leu Trp Gln Ile Ala Asn 
        115                 120                 125             


Cys Ala Pro Tyr Cys Gly Val Trp Val Ala Lys Tyr Ala Ser Met Asp 
    130                 135                 140                 


Trp Lys Ser Trp Thr Leu Pro Asn Met Ser Val Ser Ala Gly Ala Phe 
145                 150                 155                 160 


Gly Ala Leu Thr Gly Trp Gln Phe Thr Gly Gly Asp Met Asp Arg Ser 
                165                 170                 175     


Ile Phe Tyr Leu Thr Lys Glu Thr Trp 
            180                 185 


<210>  5
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hydrolase domain

<400>  5

Leu Lys Val Val Asp Val Tyr Ser Gly Ser Pro Arg Trp Tyr Ala Thr 
1               5                   10                  15      


Asp Asp Asn Ala Asp Ala Val Ile Val Lys Ala Thr Gln Gly Thr Gly 
            20                  25                  30          


Tyr Val Asn Pro Phe Cys Asp Ile Asp Tyr Gln Ala Ala Lys Lys Ala 
        35                  40                  45              


Gly Lys Leu Leu Gly Val Tyr His Tyr Ala Ser Gly Gly Asp Pro Ile 
    50                  55                  60                  


Ser Glu Ala Asn Tyr Phe Leu Lys Asn Val Lys Gly Tyr Val His Glu 
65                  70                  75                  80  


Ala Ile Leu Gly Leu Asp Trp Glu Ser Ala Gln Asn Ala Ser Trp Gly 
                85                  90                  95      


Asn Thr Asn Trp Cys Arg Gln Phe Val Asn Glu Ile His Arg Gln Thr 
            100                 105                 110         


Gly Val Trp Pro Ile Ile Tyr Val Gln Phe Ser Ala Val Trp Gln Val 
        115                 120                 125             


Ala Asn Cys Ala Asp Thr Cys Gly Leu Trp Gly Ala Gly Tyr Pro Trp 
    130                 135                 140                 


Tyr Thr Asn Ser Trp Thr Val Pro Pro Phe Leu Ser Ser Tyr Asn Phe 
145                 150                 155                 160 


Ala Pro Trp Lys Asp Leu Thr Gly Trp Gln Phe Thr Gly Asn Thr Glu 
                165                 170                 175     


Asp Arg Ser Leu Phe Tyr Val Asp Ala Asn Gly Trp 
            180                 185             


<210>  6
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hydrolase domain

<400>  6

Thr Asp Val Phe Ser Gly Ser Ala Asp Trp Ile Val Thr Asp Pro His 
1               5                   10                  15      


Ala Gln Gly Thr Ile Val Lys Ala Ser Gln Gly Thr Gly Tyr Val Asn 
            20                  25                  30          


Pro Lys Tyr Glu Tyr Gln Tyr Ser Leu Ala Lys Thr Asn Gly Arg Leu 
        35                  40                  45              


Leu Gly Leu Tyr His Tyr Ala Gly Gly Asn Asp Pro Val Ala Glu Ala 
    50                  55                  60                  


Thr Tyr Phe Leu Asp His Ile Arg Gly Lys Val Gly Glu Ala Val Leu 
65                  70                  75                  80  


Ala Val Asp Trp Glu Gln Tyr Gln Asn Ala Ala Trp Gly Asn Pro Asn 
                85                  90                  95      


Trp Val Arg Lys Phe Val Asp Glu Val His Arg Gln Thr Asn Val Trp 
            100                 105                 110         


Pro Leu Ile Tyr Val Gln Glu Ser Ala Ile Trp Gln Val Ala Asn Cys 
        115                 120                 125             


Ala Asn Asp Cys Gly Leu Trp Val Ala Lys Tyr Pro Ser Met Asn Trp 
    130                 135                 140                 


His Ser Trp Gln Val Pro Asp Met Gln Val Asn Thr Ala Pro Trp Pro 
145                 150                 155                 160 


Gly Tyr Thr Leu Trp Gln Phe Ala Gly Asp Asp Glu Asp Arg Ser Ile 
                165                 170                 175     


Ala Thr Val Asp Arg Asn Gly Trp 
            180                 


<210>  7
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell wall binding domain

<400>  7

Ser Ser Ile Asp Glu Val Ala Arg Glu Val Ile Asn Gly Ala Trp Gly 
1               5                   10                  15      


Asn Gly Lys Glu Arg Lys Gln Arg Leu Thr Gln Ala Gly Tyr Asp Tyr 
            20                  25                  30          


Ala Ser Val Gln Asn Lys Val Asn Glu Leu Leu 
        35                  40              


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell wall binding domain

<400>  8

Ser Val Asp Glu Leu Ala Arg Glu Val Ile Arg Gly Ala Trp Gly Asn 
1               5                   10                  15      


Gly Asn Glu Arg Lys Gln Arg Leu Thr Gln Ala Gly Tyr Asp Tyr Asp 
            20                  25                  30          


Thr Val Gln Lys Arg Val Asn Glu Leu Leu 
        35                  40          


<210>  9
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell wall binding domain

<400>  9

Ser Glu Ile Val Val Asp Gly Asn Val Ser Ser Val Glu Ile His Val 
1               5                   10                  15      


Pro Trp Gly Val Asn Asn Ser Val Gly Met Thr Leu Thr Arg Ala Gly 
            20                  25                  30          


Asn Val Val Thr Ala Asn Gly Ala Gly Gly Ile Lys Ala Gly Asp Ala 
        35                  40                  45              


Gln Trp Ala Lys Ala Asn Glu Thr Ile Pro Glu Gly Phe Arg Pro Thr 
    50                  55                  60                  


Ser Leu Ser Thr Ile Thr Leu Thr Gly Gly Arg Ala Ala Leu Leu Val 
65                  70                  75                  80  


Gln Pro Asp Gly Ser Met Tyr Tyr Asp Gly Asp Ala Arg Asp Cys Thr 
                85                  90                  95      


Thr His Leu Ser Gly Thr Trp Ile Thr Asn Asp Asn Gln Pro Glu 
            100                 105                 110     


<210>  10
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell wall binding domain

<400>  10

Ser Glu Ile Thr His Asp Gly Asp Ile Ser Thr Val Tyr Val His Ile 
1               5                   10                  15      


Pro Trp Ser Val Gln Gln Asp Ile Arg Met Ala Val Val Arg Val Gly 
            20                  25                  30          


Asn Val Val Thr Val Asn Gly Cys Gly Gly Met Ser Ala Gly Asp Ala 
        35                  40                  45              


Gln Trp Ala Lys Ala Asn Glu Thr Ile Pro Glu Gly Phe Arg Pro Thr 
    50                  55                  60                  


Ser Leu Ser Thr Ile Thr Leu Thr Gly Gly Arg Ala Ala Leu Leu Val 
65                  70                  75                  80  


Gln Pro Asp Gly Ser Ile Tyr Tyr Asp Gly Asp Ala Arg Asp Cys Thr 
                85                  90                  95      


Thr His Ile Ser Gly Val Trp Ile Thr Lys Asp Thr Gln Pro Lys 
            100                 105                 110     


<210>  11
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell wall binding domain

<400>  11

Gln Phe Thr Gly Gly Asp Met Asp Arg Ser Ile Phe Tyr Leu Thr Lys 
1               5                   10                  15      


Glu Thr Trp Met Lys Ile Ala Asn Pro Ser Gly Ser Lys Asp Gly Trp 
            20                  25                  30          


Gln Gly Ser Gly Asp Thr Trp Gln Tyr Phe Glu Asn Gly Ser Ala Val 
        35                  40                  45              


Lys Asn Asp Trp Arg Lys Val Asp Asn Cys Trp Tyr Tyr Leu Asp Glu 
    50                  55                  60                  


Ser Gly Asn Ala Val Thr Gly Trp Lys Gln Ile Asn Asn His Trp Tyr 
65                  70                  75                  80  


Tyr Phe Asp Thr Lys His Asp Gly Ser Phe Gly Thr Ala Leu Thr Gly 
                85                  90                  95      


Trp Gln Gln Ile Asn Gly Lys Lys Tyr Tyr Phe Asp Leu Gln Asn Ala 
            100                 105                 110         


Trp Met Leu Thr Gly Lys Gln Thr Ile Asp Gly Lys Leu Tyr Thr Phe 
        115                 120                 125             


Gly Asp Asp Gly Ala Leu 
    130                 


<210>  12
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell wall binding domain

<400>  12

Glu Asn Gly Lys Phe Thr Ala Asn Thr Asp Leu His Leu Arg Trp Gly 
1               5                   10                  15      


Ala Thr Pro Ser Ser Ser Val Ile Ser Val Leu His Ala Gly Asp Val 
            20                  25                  30          


Val Lys Tyr Asp Ala Trp Ala Arg Thr Asn Gly Phe Val Tyr Ile Arg 
        35                  40                  45              


Gln Pro Arg Gly Asn Gly Gln Tyr Gly Tyr Val Ala Val Arg 
    50                  55                  60          


<210>  13
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell wall binding domain

<400>  13

Pro Leu Thr Leu Arg Trp Gly Ala Leu Pro Thr Ser Thr Ala Ile Ala 
1               5                   10                  15      


Glu Leu Pro Ala Gly Ser Val Ile Asp Tyr Asp Ala Trp Ser Arg His 
            20                  25                  30          


Asp Gly Glu Val Trp Ile Arg Gln Pro Arg Gly Asn Gly Gln Tyr Gly 
        35                  40                  45              


Tyr Leu Pro 
    50      


<210>  14
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  14

Val Asp Tyr Pro Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys 
1               5                   10                  15      


Asn Gly Gly Ser Asp Gln Ala Ala Arg Thr 
            20                  25      


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Gly Val Lys Ala Tyr Arg Lys 
1               5           


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  16

Cys Ser Ile Arg Asp Ser Gln Asn Leu Asp Tyr Met Lys Arg Ala Gly 
1               5                   10                  15      


Asp Trp Tyr Asp Ala Met Thr Gly Val Val Lys Gln Gln Asn Gln Thr 
            20                  25                  30          


Lys Ser Gly Glu Glu Tyr Pro Met Ile Lys 
        35                  40          


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  17

Gln Ser Tyr Ala Lys Ser Asp Asn Gln Thr Gln Gln Ser Gln Glu Ala 
1               5                   10                  15      


Gln Gln Ala Glu Pro Met Pro Ala Ile 
            20                  25  


<210>  18
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  18

Gln Glu Ala Thr Thr Gln Glu Thr Lys Pro Ala Glu Ala Lys Pro Ser 
1               5                   10                  15      


Ile Asp Lys Gln Ile Val Leu Asp Asp Gln Leu Lys Ala Tyr Ile Gln 
            20                  25                  30          


Ser Glu Ile Lys Ala Gln Leu Ala Lys Leu Lys Ile Lys Met Glu Glu 
        35                  40                  45              


<210>  19
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  19

Gln Ala Ile Ala Lys Gly Asp Gly Thr Val Thr His Thr Ala Gln Pro 
1               5                   10                  15      


Ala Pro Gln Lys Asn Glu Ala Lys Thr Ser Asn Val Pro Ser Tyr Ala 
            20                  25                  30          


Gly Thr Thr Trp Gln Asp Ser Leu Gly Val Thr Trp His Ala 
        35                  40                  45      


<210>  20
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  20

Gln Arg Leu Ala Asn Pro Thr Gly Gln Val Ser Ser Arg Pro Leu Ile 
1               5                   10                  15      


Phe Gly Asp Ser Ser Ala Ser Ser Ile Ser Asn Asn Glu Thr Trp Thr 
            20                  25                  30          


Asp Asn Leu Gly Asp Thr Trp His Arg Glu Val Gly Arg Phe Thr Ser 
        35                  40                  45              


Ser Arg 
    50  


<210>  21
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endolysin polypeptide

<400>  21

Met Ser Lys Lys Gly Ile Asp Val Ser Glu Trp Gln Gly Asp Ile Asp 
1               5                   10                  15      


Phe Asn Ala Val Lys Ala Ser Gly Val Glu Phe Val Ile Ile Arg Ala 
            20                  25                  30          


Gly Tyr Gly Ile Gly Cys Lys Asp Lys Trp Phe Glu Gln Asn Tyr Arg 
        35                  40                  45              


Lys Ala Lys Thr Cys Gly Leu Asp Val Gly Ala Tyr Trp Tyr Ser Tyr 
    50                  55                  60                  


Ala Asn Ser Gly Phe Glu Ala Ala Glu Glu Ala Gln Ser Cys Val Asn 
65                  70                  75                  80  


Met Leu Ser Gly Lys Ser Phe Glu Tyr Pro Val Tyr Phe Asp Leu Glu 
                85                  90                  95      


Glu Lys Ser Gln Leu Asn Arg Gly Arg Ala Phe Cys Asp Ser Leu Ile 
            100                 105                 110         


Thr Ser Phe Cys Ser Lys Leu Glu Thr Tyr Gly Tyr Tyr Ala Gly Phe 
        115                 120                 125             


Tyr Thr Ser Leu Ser Val Ala Asn Asn Leu Val Ser Ala His Val Arg 
    130                 135                 140                 


Asn Arg Tyr Ala Leu Trp Ile Ala Gln Trp Asn Thr His Cys Asn Tyr 
145                 150                 155                 160 


Gln Gly Ser Tyr Gly Leu Trp Gln Tyr Ser Ser Ser Gly Ser Val Pro 
                165                 170                 175     


Gly Val Ala Gly Arg Val Asp Met Asp Tyr Ala Tyr Val Asp Tyr Pro 
            180                 185                 190         


Ser Ile Ile Lys Asn Ala Gly Leu Asn Gly Cys Lys Asn Gly Gly Ser 
        195                 200                 205             


Asp Gln Ala Ala Arg Thr Ser Ser Ile Asp Glu Val Ala Arg Glu Val 
    210                 215                 220                 


Ile Asn Gly Ala Trp Gly Asn Gly Lys Glu Arg Lys Gln Arg Leu Thr 
225                 230                 235                 240 


Gln Ala Gly Tyr Asp Tyr Ala Ser Val Gln Asn Lys Val Asn Glu Leu 
                245                 250                 255     


Leu Gly Val Lys Ala Tyr Arg Lys Ser Val Asp Glu Leu Ala Arg Glu 
            260                 265                 270         


Val Ile Arg Gly Ala Trp Gly Asn Gly Asn Glu Arg Lys Gln Arg Leu 
        275                 280                 285             


Thr Gln Ala Gly Tyr Asp Tyr Asp Thr Val Gln Lys Arg Val Asn Glu 
    290                 295                 300                 


Leu Leu 
305     


<210>  22
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endolysin polypeptide

<400>  22

Met Lys Asn Trp Glu Thr Cys Asp Ala Asp Glu Ile Lys Leu Leu Thr 
1               5                   10                  15      


Thr His Tyr Thr Lys Gly Arg Gln Gly Leu Lys Ile Asn Lys Ile Val 
            20                  25                  30          


Leu His His Asn Ala Gly Asn Leu Ser Ile Gln Asp Cys Tyr Asn Val 
        35                  40                  45              


Trp Gln Thr Arg Glu Ala Ser Ala His Tyr Gln Val Gln Ser Asp Gly 
    50                  55                  60                  


Arg Ile Gly Gln Leu Val Trp Asp Tyr Asp Thr Ala Trp His Ala Gly 
65                  70                  75                  80  


Asn Trp Asn Ala Asn Ala Thr Ser Ile Gly Ile Glu His Ala Asp Ile 
                85                  90                  95      


Ser Thr Ser Pro Trp Gln Ile Ser Ala Gln Cys Leu Glu Asn Gly Ala 
            100                 105                 110         


His Leu Val Ala Ala Leu Cys Lys Leu Tyr Gly Leu Gly Arg Pro Thr 
        115                 120                 125             


Trp Met Lys Asn Val Phe Pro His Ser Tyr Phe Tyr Ala Thr Ala Cys 
    130                 135                 140                 


Pro Cys Ser Ile Arg Asp Ser Gln Asn Leu Asp Tyr Met Lys Arg Ala 
145                 150                 155                 160 


Gly Asp Trp Tyr Asp Ala Met Thr Gly Val Val Lys Gln Gln Asn Gln 
                165                 170                 175     


Thr Lys Ser Gly Glu Glu Tyr Pro Met Ile Lys Ser Glu Ile Val Val 
            180                 185                 190         


Asp Gly Asn Val Ser Ser Val Glu Ile His Val Pro Trp Gly Val Asn 
        195                 200                 205             


Asn Ser Val Gly Met Thr Leu Thr Arg Ala Gly Asn Val Val Thr Ala 
    210                 215                 220                 


Asn Gly Ala Gly Gly Ile Lys Ala Gly Asp Ala Gln Trp Ala Lys Ala 
225                 230                 235                 240 


Asn Glu Thr Ile Pro Glu Gly Phe Arg Pro Thr Ser Leu Ser Thr Ile 
                245                 250                 255     


Thr Leu Thr Gly Gly Arg Ala Ala Leu Leu Val Gln Pro Asp Gly Ser 
            260                 265                 270         


Met Tyr Tyr Asp Gly Asp Ala Arg Asp Cys Thr Thr His Leu Ser Gly 
        275                 280                 285             


Thr Trp Ile Thr Asn Asp Asn Gln Pro Glu 
    290                 295             


<210>  23
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endolysin polypeptide

<400>  23

Met Ala Leu Asn Gly Ile Asp Ile Ser Ser Tyr Gln Ser Ser Ile Asn 
1               5                   10                  15      


Ile Ala Ala Val Pro Ala Asp Phe Val Ile Val Lys Ala Thr Glu Gly 
            20                  25                  30          


Thr Gly Tyr Ile Asn Pro Cys Phe Arg Ala His Ala Asp Thr Ile Leu 
        35                  40                  45              


Asn Ser Gly Lys Leu Leu Gly Ile Tyr His Tyr Ile Ser Gly Ser Gly 
    50                  55                  60                  


Trp Gln Ala Glu Ala Glu Tyr Phe Val Asn Thr Val Lys Asp Tyr Ile 
65                  70                  75                  80  


Gly Arg Ala Val Leu Ala Leu Asp Phe Glu Ser Gly Gly Asn Ser Ala 
                85                  90                  95      


Tyr Gly Asp Thr Ala Tyr Leu Gln Gln Cys Ala Gln Thr Val Tyr Asn 
            100                 105                 110         


Leu Thr Gly Val His Pro Leu Ile Tyr Gly Ser Gln Arg Asp Tyr Gly 
        115                 120                 125             


Arg Leu Ala Ala Val Ser Lys Ala Thr Asn Cys Gly Leu Trp Val Ala 
    130                 135                 140                 


Gln Tyr Ala Asn Asn Asn His Thr Gly Tyr Gln Asn Lys Pro Trp Asn 
145                 150                 155                 160 


Glu Asp Ala Tyr Asp Cys Ala Ile Arg Gln Tyr Ser Ser Ser Gly Ser 
                165                 170                 175     


Leu Pro Asn Tyr Gly Gly Asn Leu Asp Leu Asn Lys Phe Tyr Gly Asp 
            180                 185                 190         


Ala Ala Ala Trp Gln Ser Tyr Ala Lys Ser Asp Asn Gln Thr Gln Gln 
        195                 200                 205             


Ser Gln Glu Ala Gln Gln Ala Glu Pro Met Pro Ala Ile Ser Glu Ile 
    210                 215                 220                 


Thr His Asp Gly Asp Ile Ser Thr Val Tyr Val His Ile Pro Trp Ser 
225                 230                 235                 240 


Val Gln Gln Asp Ile Arg Met Ala Val Val Arg Val Gly Asn Val Val 
                245                 250                 255     


Thr Val Asn Gly Cys Gly Gly Met Ser Ala Gly Asp Ala Gln Trp Ala 
            260                 265                 270         


Lys Ala Asn Glu Thr Ile Pro Glu Gly Phe Arg Pro Thr Ser Leu Ser 
        275                 280                 285             


Thr Ile Thr Leu Thr Gly Gly Arg Ala Ala Leu Leu Val Gln Pro Asp 
    290                 295                 300                 


Gly Ser Ile Tyr Tyr Asp Gly Asp Ala Arg Asp Cys Thr Thr His Ile 
305                 310                 315                 320 


Ser Gly Val Trp Ile Thr Lys Asp Thr Gln Pro Lys 
                325                 330         


<210>  24
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endolysin polypeptide

<400>  24

Met Ala Leu Tyr Ile Val Asp Val Tyr Ser Gly Ser Ser Asp Ser Ile 
1               5                   10                  15      


Ile Gln Asp Pro His Ala Asp Gly Val Ile Val Lys Ala Thr Gln Gly 
            20                  25                  30          


Thr Ser Tyr Val Asn Pro Arg Cys Asn His Gln Trp Asp Leu Ala Gly 
        35                  40                  45              


Gln Leu Gly Lys Leu Arg Gly Leu Tyr His Tyr Ala Gly Gly Gly Asn 
    50                  55                  60                  


Pro Glu Ser Glu Ala Gln Tyr Phe Ile Asn Asn Ile Lys Asn Tyr Val 
65                  70                  75                  80  


Gly Gln Gly Ile Leu Ile Leu Asp Trp Glu Ser Tyr Gln Asn Ser Ser 
                85                  90                  95      


Trp Gly Asp Thr Ser Trp Pro Leu Arg Phe Val Thr Glu Val His Arg 
            100                 105                 110         


Leu Thr Gly Val Trp Pro Leu Ile Tyr Val Gln Glu Ser Ala Leu Trp 
        115                 120                 125             


Gln Ile Ala Asn Cys Ala Pro Tyr Cys Gly Val Trp Val Ala Lys Tyr 
    130                 135                 140                 


Ala Ser Met Asp Trp Lys Ser Trp Thr Leu Pro Asn Met Ser Val Ser 
145                 150                 155                 160 


Ala Gly Ala Phe Gly Ala Leu Thr Gly Trp Gln Phe Thr Gly Gly Asp 
                165                 170                 175     


Met Asp Arg Ser Ile Phe Tyr Leu Thr Lys Glu Thr Trp Met Lys Ile 
            180                 185                 190         


Ala Asn Pro Ser Gly Ser Lys Asp Gly Trp Gln Gly Ser Gly Asp Thr 
        195                 200                 205             


Trp Gln Tyr Phe Glu Asn Gly Ser Ala Val Lys Asn Asp Trp Arg Lys 
    210                 215                 220                 


Val Asp Asn Cys Trp Tyr Tyr Leu Asp Glu Ser Gly Asn Ala Val Thr 
225                 230                 235                 240 


Gly Trp Lys Gln Ile Asn Asn His Trp Tyr Tyr Phe Asp Thr Lys His 
                245                 250                 255     


Asp Gly Ser Phe Gly Thr Ala Leu Thr Gly Trp Gln Gln Ile Asn Gly 
            260                 265                 270         


Lys Lys Tyr Tyr Phe Asp Leu Gln Asn Ala Trp Met Leu Thr Gly Lys 
        275                 280                 285             


Gln Thr Ile Asp Gly Lys Leu Tyr Thr Phe Gly Asp Asp Gly Ala Leu 
    290                 295                 300                 


Gln Glu Ala Thr Thr Gln Glu Thr Lys Pro Ala Glu Ala Lys Pro Ser 
305                 310                 315                 320 


Ile Asp Lys Gln Ile Val Leu Asp Asp Gln Leu Lys Ala Tyr Ile Gln 
                325                 330                 335     


Ser Glu Ile Lys Ala Gln Leu Ala Lys Leu Lys Ile Lys Met Glu Glu 
            340                 345                 350         


<210>  25
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endolysin polypeptide

<400>  25

Met Ser Leu Lys Val Val Asp Val Tyr Ser Gly Ser Pro Arg Trp Tyr 
1               5                   10                  15      


Ala Thr Asp Asp Asn Ala Asp Ala Val Ile Val Lys Ala Thr Gln Gly 
            20                  25                  30          


Thr Gly Tyr Val Asn Pro Phe Cys Asp Ile Asp Tyr Gln Ala Ala Lys 
        35                  40                  45              


Lys Ala Gly Lys Leu Leu Gly Val Tyr His Tyr Ala Ser Gly Gly Asp 
    50                  55                  60                  


Pro Ile Ser Glu Ala Asn Tyr Phe Leu Lys Asn Val Lys Gly Tyr Val 
65                  70                  75                  80  


His Glu Ala Ile Leu Gly Leu Asp Trp Glu Ser Ala Gln Asn Ala Ser 
                85                  90                  95      


Trp Gly Asn Thr Asn Trp Cys Arg Gln Phe Val Asn Glu Ile His Arg 
            100                 105                 110         


Gln Thr Gly Val Trp Pro Ile Ile Tyr Val Gln Phe Ser Ala Val Trp 
        115                 120                 125             


Gln Val Ala Asn Cys Ala Asp Thr Cys Gly Leu Trp Gly Ala Gly Tyr 
    130                 135                 140                 


Pro Trp Tyr Thr Asn Ser Trp Thr Val Pro Pro Phe Leu Ser Ser Tyr 
145                 150                 155                 160 


Asn Phe Ala Pro Trp Lys Asp Leu Thr Gly Trp Gln Phe Thr Gly Asn 
                165                 170                 175     


Thr Glu Asp Arg Ser Leu Phe Tyr Val Asp Ala Asn Gly Trp Gln Ala 
            180                 185                 190         


Ile Ala Lys Gly Asp Gly Thr Val Thr His Thr Ala Gln Pro Ala Pro 
        195                 200                 205             


Gln Lys Asn Glu Ala Lys Thr Ser Asn Val Pro Ser Tyr Ala Gly Thr 
    210                 215                 220                 


Thr Trp Gln Asp Ser Leu Gly Val Thr Trp His Ala Glu Asn Gly Lys 
225                 230                 235                 240 


Phe Thr Ala Asn Thr Asp Leu His Leu Arg Trp Gly Ala Thr Pro Ser 
                245                 250                 255     


Ser Ser Val Ile Ser Val Leu His Ala Gly Asp Val Val Lys Tyr Asp 
            260                 265                 270         


Ala Trp Ala Arg Thr Asn Gly Phe Val Tyr Ile Arg Gln Pro Arg Gly 
        275                 280                 285             


Asn Gly Gln Tyr Gly Tyr Val Ala Val Arg Asn Ala Tyr Thr Asn Glu 
    290                 295                 300                 


Ala Tyr Gly Lys Phe Glu 
305                 310 


<210>  26
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Endolysin polypeptide

<400>  26

Met Ala Leu Tyr Phe Thr Asp Val Phe Ser Gly Ser Ala Asp Trp Ile 
1               5                   10                  15      


Val Thr Asp Pro His Ala Gln Gly Thr Ile Val Lys Ala Ser Gln Gly 
            20                  25                  30          


Thr Gly Tyr Val Asn Pro Lys Tyr Glu Tyr Gln Tyr Ser Leu Ala Lys 
        35                  40                  45              


Thr Asn Gly Arg Leu Leu Gly Leu Tyr His Tyr Ala Gly Gly Asn Asp 
    50                  55                  60                  


Pro Val Ala Glu Ala Thr Tyr Phe Leu Asp His Ile Arg Gly Lys Val 
65                  70                  75                  80  


Gly Glu Ala Val Leu Ala Val Asp Trp Glu Gln Tyr Gln Asn Ala Ala 
                85                  90                  95      


Trp Gly Asn Pro Asn Trp Val Arg Lys Phe Val Asp Glu Val His Arg 
            100                 105                 110         


Gln Thr Asn Val Trp Pro Leu Ile Tyr Val Gln Glu Ser Ala Ile Trp 
        115                 120                 125             


Gln Val Ala Asn Cys Ala Asn Asp Cys Gly Leu Trp Val Ala Lys Tyr 
    130                 135                 140                 


Pro Ser Met Asn Trp His Ser Trp Gln Val Pro Asp Met Gln Val Asn 
145                 150                 155                 160 


Thr Ala Pro Trp Pro Gly Tyr Thr Leu Trp Gln Phe Ala Gly Asp Asp 
                165                 170                 175     


Glu Asp Arg Ser Ile Ala Thr Val Asp Arg Asn Gly Trp Gln Arg Leu 
            180                 185                 190         


Ala Asn Pro Thr Gly Gln Val Ser Ser Arg Pro Leu Ile Phe Gly Asp 
        195                 200                 205             


Ser Ser Ala Ser Ser Ile Ser Asn Asn Glu Thr Trp Thr Asp Asn Leu 
    210                 215                 220                 


Gly Asp Thr Trp His Arg Glu Val Gly Arg Phe Thr Ser Ser Arg Pro 
225                 230                 235                 240 


Leu Thr Leu Arg Trp Gly Ala Leu Pro Thr Ser Thr Ala Ile Ala Glu 
                245                 250                 255     


Leu Pro Ala Gly Ser Val Ile Asp Tyr Asp Ala Trp Ser Arg His Asp 
            260                 265                 270         


Gly Glu Val Trp Ile Arg Gln Pro Arg Gly Asn Gly Gln Tyr Gly Tyr 
        275                 280                 285             


Leu Pro Cys Arg Asn Ala Val Thr Asn Glu Ala Tyr Gly Thr Phe Ser 
    290                 295                 300                 


Glu 
305 


